CN114010948A

CN114010948A - Filter for photodynamic therapy under endoscope

Info

Publication number: CN114010948A
Application number: CN202111091910.1A
Authority: CN
Inventors: 张兵; 王宏志; 程庭清; 梁敏; 储焰南
Original assignee: Hefei Institutes of Physical Science of CAS
Current assignee: Hefei Institutes of Physical Science of CAS
Priority date: 2021-09-17
Filing date: 2021-09-17
Publication date: 2022-02-08

Abstract

The invention discloses a filter for photodynamic therapy under an endoscope, which is arranged at the front end of the endoscope and can filter light with specific wavelength, namely background light, and the output end of the filter faces the front end of the endoscope. The filter can filter background light caused by the laser emitted from the optical fiber to the outside, filter the interference of the treatment laser to optical imaging, and still can obtain clear optical images through an endoscope in the treatment process, thereby helping doctors to operate and treat more conveniently, reducing the difficulty of the operation, improving the accuracy of the operation and greatly improving the treatment effect.

Description

Filter for photodynamic therapy under endoscope

Technical Field

The invention relates to the technical field of photodynamic therapy, in particular to a filter for photodynamic therapy under an endoscope.

Background

Photodynamic Therapy (PDT) is applied to tumor treatment, and is a non-invasive treatment method for selectively killing tumor cells. Compared with the traditional operation, radiotherapy and chemotherapy, the traditional Chinese medicine composition has the characteristics of minimal or no wound, targeted therapy, high applicability, repeatability, no drug resistance and the like. During treatment, a photosensitive medicament is externally applied or injected intravenously, the photosensitive medicament can be selectively, high-concentration and long-time gathered in tumor tissues, most of photosensitizers in normal tissues can be discharged out of the body within 24-48 hours, then specific wavelength laser, namely treatment laser, corresponding to the photosensitizers is adopted to irradiate the tumor tissues within a certain time interval, the photosensitizers which are retained in the tumor tissues absorb the laser energy of the treatment laser, a series of chemical withdrawal reactions are carried out to generate singlet oxygen or free radicals with strong activity, the products can kill tumor cells, the tumor tissues are changed into necrotic tissues, and then the necrotic tissues are stripped, shed or absorbed by the body. Photodynamic therapy requires three basic components: oxygen, photosensitizer, visible light, i.e. therapeutic laser.

When the photodynamic therapy is carried out on the tumor tissue in the body, an endoscope technology is needed to be adopted, the medical laser optical fiber is sent to a focus part, the optical fiber is sent to the focus tissue in the body through the endoscope, the optical fiber emits the treatment laser and irradiates the focus tissue, in the laser irradiation process, an operating doctor is needed to continuously observe the focus tissue, and an optical image is obtained through the endoscope, so that the focus tissue is observed, the transmitting end of the optical fiber is observed, and the irradiation position of the laser is adjusted. Currently, commonly used endoscopes include electronic endoscopes and fiberscope endoscopes. The endoscope mostly adopts the modes of white light irradiation and optical imaging to obtain an in-vivo optical image in real time. However, when the optical fiber emits laser outwards to irradiate tumor tissue, under the irradiation of high-brightness and high-intensity laser, a strong background light is generated, so that a clear optical image cannot be obtained through an endoscope, an optical image in the treatment process cannot be displayed on a monitor, and focal tissues in the treatment process and the emission end of the optical fiber cannot be observed. In the prior art, in order to solve the problem, the treatment needs to be stopped every 1-3 min in the treatment process, namely, the outward laser of the optical fiber is cut off every 1-3 min, so that the change of focal tissues is observed and correspondingly adjusted, the operation difficulty is increased, the operation precision is reduced, and the treatment effect is greatly reduced.

Disclosure of Invention

In order to overcome the defects in the prior art, the invention provides the filter for photodynamic therapy under the endoscope, which can filter background light caused by laser emitted outwards by the optical fiber, can still obtain clear optical images through the endoscope in the treatment process, helps doctors to operate and treat more conveniently, reduces the difficulty of the operation, improves the operation precision, and greatly improves the treatment effect.

In order to achieve the purpose, the invention adopts the following technical scheme that:

a filter for photodynamic therapy under an endoscope is arranged on the front end of the endoscope, and the output end of the filter faces the front end of the endoscope; the filter is used for filtering light with specific wavelength.

The filter includes: the filter film is used for filtering light with specific wavelength;

light of a particular wavelength is referred to as: the same light as the wavelength of the therapeutic laser, i.e. the same wavelength as the laser emitted by the optical fiber in the endoscope.

The filter includes: the filter films are stacked to form a filter film group, are arranged on the front end of the endoscope and are used for filtering light with different wavelengths.

The filter film is plated on the end face of the transparent substrate, the transparent substrate and the filter film plated on the end face of the transparent substrate form a filter, and the filter is arranged on the front end of the endoscope.

The filter comprises a plurality of optical filters which are arranged along the axial direction to form an optical filter group, and the optical filter group is arranged at the front end of the endoscope and used for filtering a plurality of light with different wavelengths.

The two end faces of the transparent substrate are respectively plated with a filter film, and the filter films plated on the two end faces have different filter wavelengths and are used for filtering light with two different wavelengths.

The filter is provided with a first through hole through which an optical fiber in the endoscope can penetrate.

The first through hole is aligned with an optical fiber penetrating and exiting port on the front end of the endoscope.

The value range of the hole diameter d1 of the first through hole is 1 mm-4 mm.

The invention has the advantages that:

(1) the filter is arranged at the front end of the endoscope, can filter background light caused by laser emitted outwards by the optical fiber, can obtain clear optical images through the endoscope in the treatment process, does not need to stop treatment every 1-3 min in the treatment process, reduces the difficulty of the operation, improves the operation precision, and greatly improves the treatment effect.

(2) The filter provided by the invention selectively filters the interference of the treatment laser on optical imaging by adopting a narrow-band filtering mode on the treatment laser, and can obtain clear real-time images under the irradiation of white light, thereby helping doctors to operate and treat more conveniently.

(3) The filter is provided with the through holes with the thickness of 1 mm-4 mm, so that the passing and the use of optical fibers with different specifications are met.

(4) The filter film is selectively plated on the end face of the transparent substrate to form the optical filter, so that the filter is simple and convenient to mount and dismount, can be used at one time, and can be reused after being sterilized.

(5) The filter can be used for filtering two lights with different wavelengths and meeting the use requirements of different photodynamic laser light sources by selecting two different narrow-band total reflection films, namely filter films, plated on two end faces of the transparent substrate of the filter aiming at different light sources.

(6) The filter provided by the invention can select a plurality of optical filters to be arranged along the axial direction to form an optical filter group aiming at more light sources with different wavelengths, and is used for filtering a plurality of light with different wavelengths, so that the use of more photodynamic laser light sources is met.

Drawings

Fig. 1 is a first schematic diagram of a filter for endoscopic photodynamic therapy according to the present invention.

Fig. 2 is a second schematic diagram of a filter for endoscopic photodynamic therapy according to the present invention.

Fig. 3 is a third schematic diagram of a filter for endoscopic photodynamic therapy according to the present invention.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

When treating internal tumour tissue, adopt the scope technique, optic fibre 3 sends into internal focus tissue department through scope 2, treatment laser is launched to optic fibre, and shine and put focus tissue, among the laser irradiation process, need the operation doctor constantly to observe focus tissue, acquire optical image through scope 2, thereby observe focus tissue and observe the transmitting terminal of optic fibre 3, thereby adjust the irradiation position of laser, but because optic fibre 3 outwards launches laser, at hi-lite, under the laser irradiation of high strength, cause a very strong background light, make and can't acquire clear optical image through scope 2, thereby can't observe focus tissue and observe the transmitting terminal of optic fibre 3. In the prior art, in order to solve the problem, the treatment needs to be stopped every 1-3 min in the treatment process, namely, the outward-emitting laser of the optical fiber 3 is cut off every 1-3 min, so that the change of the lesion tissues is observed and correspondingly adjusted. However, in the present invention, a filter is disposed at the front end 21 of the endoscope 2 to filter out background light caused by the laser emitted from the optical fiber 3, so that a clear optical image can be obtained through the endoscope 2.

Referring to fig. 1, a filter for photodynamic therapy under an endoscope is disposed at an endoscope front end 21, and an output end of the filter faces the endoscope front end. The filter can filter out light with specific wavelength, namely background light.

Light of a particular wavelength is referred to as: the same light as the wavelength of the treatment laser, i.e. the same wavelength as the laser emitted by the optical fiber 3 in the endoscope 2.

The filter comprises a filter film 11 for filtering light with specific wavelength; the filter film 11 is a narrow-band total reflection film.

The filter may include a plurality of filter films 11, and the plurality of filter films 11 are stacked to form a filter film group, and disposed on the endoscope front end 21, so as to filter light with different wavelengths, and meet the use requirements of different photodynamic laser light sources.

The filter, namely the filter film 11 or the filter film group, is provided with a first through hole 13 through which the optical fiber 3 in the endoscope 2 can penetrate; the first through hole 13 is aligned with the fiber passage opening on the endoscope front end 21.

The hole diameter d1 of the first through hole 13 is more than or equal to d2+ a; where d2 is the diameter of fiber 3; a is a set threshold value, and the value range of a is 0.5 mm-4 mm. Or, the value range of the hole diameter d1 of the first through hole 13 is directly set to be 1 mm-4 mm.

As shown in fig. 2, the filter film 11 can be selectively plated on the end surface of the transparent substrate 12, the transparent substrate 12 can be a glass sheet, the thickness of the transparent substrate 12 is 0.5mm to 3mm, the transparent substrate 12 and the filter film 11 plated on the end surface of the transparent substrate 12 form the optical filter 1, and the optical filter 1 is connected with the endoscope front end 21.

Both end surfaces of the transparent substrate 12 of the optical filter 1 may be plated with the optical filter 11, and if the filtering wavelengths of the optical filter 12 plated on both end surfaces are different, light with two different wavelengths can be filtered.

As shown in fig. 3, a plurality of filters 1 may be used as the filter, and a filter group may be formed by arranging the plurality of filters 1 in the axial direction and disposed on the endoscope distal end 21. The filter film 11 coated on the end face of the transparent substrate 12 of each filter 1 has different filtering wavelengths, and the filter set formed by arranging the plurality of filters 1 along the axial direction can filter light with various wavelengths. Wherein, two end faces of the transparent substrate 12 of the plurality of optical filters 1 can be selected to be coated with the filter coating 11 on one end face, or both end faces are coated with the filter coating 11; the plurality of filters 1 may be attached to or detached from each other in the axial direction. Fig. 3 shows a filter set in which two filters 11 are arranged in the axial direction.

The invention is not to be considered as limited to the specific embodiments shown and described, but is to be understood to cover all modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.

Claims

1. A filter for photodynamic therapy under an endoscope is characterized in that the filter is arranged on the front end (21) of the endoscope, and the output end of the filter faces the front end (21) of the endoscope; the filter is used for filtering light with specific wavelength.

2. The filter for endoscopic photodynamic therapy according to claim 1, wherein said filter comprises: a filter film (11) for filtering light of a specific wavelength;

light of a particular wavelength is referred to as: the light with the same wavelength as the treatment laser, namely the light with the same wavelength as the laser emitted by the optical fiber (3) in the endoscope (2).

3. The filter for endoscopic photodynamic therapy according to claim 2, wherein said filter comprises: the filter films (11) are stacked to form a filter film group, and the filter film group is arranged on the front end (21) of the endoscope and used for filtering light with different wavelengths.

4. A filter for use in photodynamic therapy under an endoscope according to claim 2, wherein the filter film (11) is coated on an end surface of the transparent substrate (12), the transparent substrate (12) and the filter film (11) coated on the end surface of the transparent substrate (12) form a filter (1), and the filter (1) is disposed on a front end (21) of the endoscope.

5. A filter for use in photodynamic therapy under endoscope according to claim 4, characterized in that said filter comprises a plurality of filters (1), said plurality of filters (1) being arranged in an axial direction to form a filter set, said filter set being disposed at the front end (21) of the endoscope for filtering a plurality of light beams having different wavelengths.

6. A filter for use in photodynamic therapy under endoscope according to claim 4 or 5, characterized in that two end faces of the transparent substrate (12) are coated with respective light filters (11), and the light filters (11) coated on the two end faces have different filtering wavelengths for filtering light with two different wavelengths.

7. A filter for use in photodynamic therapy under an endoscope according to claim 1, 2, 3, 4 or 5, wherein the filter is provided with a first through hole (13) through which the optical fiber (3) in the endoscope (2) can pass.

8. A filter for use in photodynamic therapy under an endoscope according to claim 7, characterized in that said first through hole (13) is aligned with an optical fiber passage opening in the front end (21) of the endoscope.

9. A filter for endoscopic photodynamic therapy according to claim 7, wherein the hole diameter d1 of the first through hole (13) has a value in the range of 1mm to 4 mm.