CN102553084B - Phototherapy device - Google Patents
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- CN102553084B CN102553084B CN201210053425.XA CN201210053425A CN102553084B CN 102553084 B CN102553084 B CN 102553084B CN 201210053425 A CN201210053425 A CN 201210053425A CN 102553084 B CN102553084 B CN 102553084B
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Abstract
The embodiment of the invention discloses a phototherapy device. The phototherapy device comprises a light source, a light guide system, a control system and a lighting refraction system, wherein the light source is used for conducting light with fixed wavelength to the light guide system, namely receiving light with fixed wavelength and from a light-filtering device and conducting the light with fixed wavelength to the light guide system; the light guide system is used for entering the body of a patient to be treated under the control of the control system and conducting the light with fixed wavelength and guided by the light source to the lighting refraction system; the control system is used for controlling the light guide system to enter the body of the patient to be treated, so that the lighting refraction system positioned at the front end of the light guide system reaches the focus in the body of the patient; and the lighting refraction system is used for irradiating the light with fixed wavelength and conducted by the light guide system on the focus in the body of the patient. The tubular continuous phototherapy device applied in the cavity is provided with tubular light-emitting diode (LED) encapsulation based on the cavity organs and optical path design and can provide uniform intracavity irradiation.
Description
Technical field
The present invention relates to medical instruments field, relate in particular to a kind of Phototherapeutic device.
Background technology
Photodynamic therapy (Photodynamic Therapy, PDT) former title photoradiation therapy (Photoradiation Therapy, PRT), photochemotherapy (Photochemical Therapy, PCT), it is to utilize light to carry out a kind of new technique of medical diagnosis on disease and treatment.PDT application clinically can be divided into photodynamic diagnosis (being called again fluorescence diagnosis) and light treatment.Clinically, photodynamic therapy only refers to light treatment conventionally, and light power diagnosis is called to fluorescence diagnosis.Light treatment is spectrum irradiation human body surface or the housing surface that utilizes specific band, can effectively kill sick cell organize by photo-thermal complex effect, and mucosal tissue is solidified, and blood vessel solidifies obturation, reaches healing object.
Photodynamic therapy is under the light of specific wavelength and the synergism of photosensitizer, to make the oxygen molecule in cell produce free radical and single oxygen atom, causes cytotoxicity, reaches the effect for the treatment of disease.At present, photodynamic therapy has been successfully applied to treatment dermatosis and tumor, as actinic keratosis, basal cell carcinoma, Bowen's disease etc.And the application being widely known by the people is most exactly to be used for the treatment of acne, blue light illumination propionibacterium acnes can make its endogenic porphyrin generation photochemical reaction, produce singlet oxygen, thereby kill bacteria reaches the effect of Acne treatment.More and more studies have shown that a lot of antibacterials are as Gram-positive golden staphylococci, Gram negative Detection of Porphyromonas genus, general Bordetella, haemophilus etc., by being killed after the irradiation of specific wavelength, as the light of 405nm can be killed helicobacter pylori, the light of 617nm can be killed haemophilus parainfluenzae, and the light of 664nm can be killed golden staphylococci etc.
Photodynamic therapy is more and more extensive in application medically, and up to the present existing a plurality of hospitals adopt photodynamic therapy that the aspects such as tumor, infectious disease are diagnosed and treated clinically.As in (as dermatosis) aspect infectious disease treatment, the diagnosis and treatment of photodynamic therapy have obtained good effect.Compared to traditional treatment mode, the advantage of photodynamic therapy is hardly can scar, and large for area, and quantity is many, or the focus of obscure boundary Chu implements relatively easily, is also another selection while cannot or be unwilling to accept traditional treatment.Side effect is conventionally also slighter.The HONGGUANG of high-purity, high power density, blue light and gold-tinted can also change cellularity, kill antibacterial.
Also there are some researches show that in the recent period in human body, multiple pathogen (wherein take helicobacter pylori as outstanding) can be killed by visible ray, the reddish blue light that the best light wave of sterilization effect has been.The mechanism of killing of helicobacter pylori is that this material has very strong absworption peak to the light wave in the nanometer range of 405+/-25 based on producing a kind of endogenous photosensitizers " porphyrin " in its body, in approximately 505,550,570 and 655 nanometers, has less absworption peak.There is chemical de excitation reaction in " porphyrin " that absorb after light wave, can generate a large amount of active oxygens, singlet oxygen most importantly wherein, active oxygen can with multiple interaction of biomacromolecules, damaging cells structure or affect cell function, thereby generation killing action.
Visible ray can transmit enough energy in these narrow wave-length coverages, and these energy can be killed most of antibacterials.And the effect that light wave is killed is remarkable, not only along surface effectively, under surface, also there is good curative effect.The degree of depth that different light is penetrated into tissue is different and difference to some extent with wavelength, and wavelength is longer, penetrates darker.The light ware energy of 400 nanometers penetrates about 1mm, and the light ware energy of 650 nanometers penetrate about 3mm or more than.Therefore, can select the light wave of different wave length can reach the treatment degree of depth of wanting according to required penetration depth.The specially good effect wavelength of killing helicobacter pylori is 400 nanometers.In addition, multicolored radiance can provide effectively and more deep therapeutic effect.General this therapeutic effect can be killed the antibacterial of 99%-99.9%, and host's autoimmune system is also enough to kill remaining antibacterial.
The light source of generally selecting for the photo-therapeutic instrument of optical dynamic therapy at present has fluorescent lamp, electric filament lamp, LED, laser and chemiluminescence source etc., is generally to use the method for similar endoscope illuminator that 1～2 light source is set.But the shortcoming of this photo-therapeutic instrument is fairly obvious.Its major defect has as follows: 1, light source is single, irradiates inhomogeneous; 2, light source radiating angle is restricted, can not reach 360 ° of irradiations; 3,, in order to reach certain exposure rate, it is a hot spot that irradiation area is concentrated, and is not suitable for large-scale treatment.For addressing the above problem, some photo-therapeutic instruments use spherical or oval-shaped air bag that cavity is strutted to broaden one's vision in scope, but because the restriction range of exposures of light source is still hot spot.At present also having photodynamic therapy lamp is the luminous body being synthesized by led array group, and luminous general power increases, but can only be for external.Therefore the problems referred to above do not obtain basic solution.
Summary of the invention
Embodiment of the present invention technical problem to be solved is, a kind of tubular continuous light therapy equipment that is applied to intracavity is provided, this Phototherapeutic device is a kind of novel medical apparatus and instruments of full pipeline internal therapy or the adnexa of existing endoscopic assistance, this Phototherapeutic device has tubular LED encapsulation and the light path design based on cavity organ, and uniform intra cavitary irradiation can be provided.
In order to solve the problems of the technologies described above, the embodiment of the present invention provides a kind of Phototherapeutic device that is applied to intracavity, comprising: light source, control system, light-conducting system and illumination dioptric system;
Light source, conducts in described light-conducting system for having the light of fixed wave length to the conduction of described light-conducting system, comprise to receive from filtering apparatus and the light that has the light of fixed wave length and this is had to fixed wave length;
Light-conducting system, for entering in patient body to be treated under the control of described control system, and by by described light source, light that import, that have fixed wave length conducts to described illumination dioptric system;
Control system, enters in patient body to be treated for controlling described light-conducting system, and the illumination dioptric system that makes to be positioned at described light-conducting system front end arrives the affected area of patient body;
Illumination dioptric system, for being radiated at uniformly the focus in patient body by the light with fixed wave length of described light-conducting system conduction.
Wherein, described Phototherapeutic device also comprises:
Spectral match system, for selecting the spectrum of different wave length to match colors according to patient's focus, kills the bacterium of curing the disease of affected area as radiation source, the wave-length coverage of described spectrum comprises: 360nm to 420nm.
Wherein, described light source comprises: illumination light module and treatment optical module;
Illumination light module, is used to the endoscope of described Phototherapeutic device front end that illumination is provided;
Treatment optical module, is used to conduction in described light-conducting system and has light fixed wave length, that be used for the treatment of patient body inner disease foci.
Wherein, described treatment optical module comprises:
LED light source, for generation of or receive from light this filtering apparatus, that there is fixed wave length; Described light source adopts pipe property LED;
Photodetector, for detection of light output situation;
Control circuit, is coupled to the power supply unit of described LED light source, for adjust the brightness of described LED light source and the work of controlling modulation member according to the detection signal of described photodetector;
Modulation member, under the control of described control circuit, regulates and patient's focus is carried out to the duration of illumination and the interval duration between twice illumination at every turn;
Filter wheel, for controlling type and the wavelength through the light of this filter wheel; The type of described light comprises ultraviolet light, infrared light, visible ray;
Light intensity detector, for detection of seeing through, pass to patient's light intensity from filter wheel, and is identified for this patient's dosage based on this light intensity;
Spectroanalysis instrument, for receiving and analyze from the light of patient's affected area reflection.
Wherein, described illumination light module comprises:
The first primary lights semiconductor light sources, for sending the first primary lights;
The second primary lights semiconductor light sources, for sending the second primary lights;
Collecting lens, is positioned in the light path of the first primary lights and the second primary lights, for converging the first primary lights and the second primary lights;
Optical fiber, its one end is positioned at collecting lens focus place, and the other end connects endoscope.
Wherein, described illumination dioptric system is led emitter surface by the light of light source by a branch of optical fiber, at the end of each optical fiber, prism is set, and the effect by prism makes light evenly diffuse to surrounding, arrives luminal surface/deep tissue; Or
End at optical fiber arranges reflectance coating, and a part of light transmission is gone out, and the light of another part evenly diffuses to arrival luminal surface/deep tissue; Or
In emitter surface, corresponding optical channel is set, light is evenly shed by described optical channel, arrive luminal surface/deep tissue.
Wherein, described Phototherapeutic device also comprises: sacculus;
Described balloon structure comprises: body, gastric balloon and/or esophagus air bag; Gastric balloon and/or esophagus air bag are communicated with body near one end of body, and body is used for to gastric balloon and/or esophagus balloon inflation/deflation, and extract esophagus liquid, gastric juice;
Gastric balloon and/or esophagus air bag, for entering after patient's cavity with Phototherapeutic device at it, make the relatively described patient's cavity of described Phototherapeutic device fix and prevent stomach, esophagus haemorrhage.
Wherein, the length of described esophagus air bag is 8～12 centimetres.
Wherein, described Phototherapeutic device also comprises accessory entrance, for from then on mouthful entering in patient body for mate-assist therapy equipment.
Wherein, described Phototherapeutic device enters in patient body by patient's oral cavity or nasal cavity.
The Phototherapeutic device that the embodiment of the present invention provides can be realized and cover the light treatment of any infected zone completely, and provide the rayed of the optical density such as intimate, solve the problem that hot spot type irradiation apparatus cannot Large-Area-Uniform irradiates, the position edema that effectively reduces inflammation congested phenomenon simultaneously, improve microcirculation, promote tissue repair healing and solve drug tolerant bacteria intracavity to infect the problem that cannot effect a radical cure.The Phototherapeutic device drug treatment that the embodiment of the present invention provides is short, can predict complication low, has safety.And there is the design of histocompatibility sacculus.
Accompanying drawing explanation
In order to be illustrated more clearly in the embodiment of the present invention or technical scheme of the prior art, to the accompanying drawing of required use in embodiment or description of the Prior Art be briefly described below, apparently, accompanying drawing in the following describes is only some embodiments of the present invention, for those of ordinary skills, do not paying under the prerequisite of creative work, can also obtain according to these accompanying drawings other accompanying drawing.
Fig. 1 is Phototherapeutic device the first example structure schematic diagram provided by the invention;
Fig. 2 is Phototherapeutic device the second example structure schematic diagram provided by the invention;
Fig. 3 is that optical fiber connector arranges prism, and the effect by prism makes light evenly diffuse to the schematic diagram of surrounding;
Fig. 4 is that emitter surface arranges optical channel, the schematic diagram that light is evenly shed;
Fig. 5 is single led light path schematic diagram;
Fig. 6 is single led irradiation schematic diagram;
Fig. 7 is the irradiation schematic diagram of a plurality of LED;
Fig. 8 is the distribution schematic diagram of a plurality of LED of plane receiving plane;
Fig. 9 is the schematic diagram of the illumination of receiving plane while reaching reasonable uniformity coefficient;
Figure 10 is Phototherapeutic device provided by the invention the 3rd example structure schematic diagram.
The specific embodiment
The Phototherapeutic device that the embodiment of the present invention provides can be realized and cover the light treatment of any infected zone completely, and provide the rayed of the optical density such as intimate, solve the problem that hot spot type irradiation apparatus cannot Large-Area-Uniform irradiates, the position edema that effectively reduces inflammation congested phenomenon simultaneously, improve microcirculation, promote tissue repair healing and solve drug tolerant bacteria intracavity to infect the problem that cannot effect a radical cure.The Phototherapeutic device drug treatment that the embodiment of the present invention provides is short, can predict complication low, has safety.And there is the design of histocompatibility sacculus.
Phototherapeutic device provided by the invention mainly comprises following components: 1, spectral match system; 2, can send the light source of specific wavelength (for example 420nm, 850nm and 940nm); 3, light-conducting system; 4, intracavity illumination dioptric system; 5, mate-assist therapy system.Device provided by the invention both can be used as independently therapy equipment, also can coordinate with conventional endoscope, or use as the accessory of conventional endoscope, and its principle is consistent.For convenience of description, various embodiments of the present invention be take situation that this Phototherapeutic device coordinates with conventional endoscope and are described as example.
Below in conjunction with the accompanying drawing in the embodiment of the present invention, the technical scheme in the embodiment of the present invention is clearly and completely described, obviously, described embodiment is only the present invention's part embodiment, rather than whole embodiment.Embodiment based in the present invention, those of ordinary skills, not making the every other embodiment obtaining under creative work prerequisite, belong to the scope of protection of the invention.
Referring to Fig. 1, be Phototherapeutic device the first example structure schematic diagram provided by the invention, as shown in the figure, this device includes but not limited to: light source 1, control system 2, light-conducting system 3 and illumination dioptric system 4.
Light source 1, receives from filtering apparatus and have the light of fixed wave length, and the light that this is had to fixed wave length conducts in described light-conducting system 3 for having the light of fixed wave length to 3 conduction of described light-conducting system, comprising.
Light-conducting system 3, for entering in patient body to be treated under the control of described control system, and will conduct to described illumination dioptric system 4 by described light source 1 light that import, that have fixed wave length.
Control system 2, enters in patient body to be treated for controlling described light-conducting system 3, and the illumination dioptric system 4 that makes to be positioned at described light-conducting system 3 front ends arrives the affected area of patient bodies.
Illumination dioptric system 4, for being radiated at uniformly the focus in patient body by the light with fixed wave length of described light-conducting system 3 conduction.
The Phototherapeutic device that the embodiment of the present invention provides can be realized and cover the light treatment of any infected zone completely, and provide the rayed of the optical density such as intimate, solve the problem that hot spot type irradiation apparatus cannot Large-Area-Uniform irradiates, the position edema that effectively reduces inflammation congested phenomenon simultaneously, improve microcirculation, promote tissue repair healing and solve drug tolerant bacteria intracavity to infect the problem that cannot effect a radical cure.The Phototherapeutic device drug treatment that the embodiment of the present invention provides is short, can predict complication low, has safety.
Referring to Fig. 2, it is Phototherapeutic device the second example structure schematic diagram provided by the invention.In the present embodiment, by the structure of more detailed this Phototherapeutic device of description and and the function of parts.As shown in the figure, this Phototherapeutic device comprises: spectral match system 5, light source 1, light-conducting system 3, control system 2, illumination dioptric system 4.
Spectral match system 5, for selecting the spectrum of different wave length to match colors according to patient's focus, kills the bacterium of curing the disease of affected area as radiation source, the wave-length coverage of described spectrum comprises: 360nm to 420nm.Now have and much studies have shown that a lot of antibacterials can be killed after the irradiation of specific wavelength, as the light of 405nm, can kill helicobacter pylori, the light of 617nm can be killed haemophilus parainfluenzae, and the light of 664nm can be killed golden staphylococci etc.This installs us and selects 360nm-420nm spectrum to match colors, and as radiation source, kills the gastrointestinal tract bacterium of curing the disease.
Light source 1, receives from filtering apparatus and have the light of fixed wave length, and the light that this is had to fixed wave length conducts in described light-conducting system 3 for having the light of fixed wave length to 3 conduction of described light-conducting system, comprising.More specifically, described light source comprises: treatment optical module and illumination light module.Treatment optical module, is used to conduction in described light-conducting system 3 and has light fixed wave length, that be used for the treatment of patient body inner disease foci.Illumination light module, is used to the endoscope of described Phototherapeutic device front end that illumination is provided.
Further, described treatment optical module comprises: LED light source, photodetector, control circuit, modulation member, filter wheel, light intensity detector and spectroanalysis instrument.
LED light source, for generation of or receive from light this filtering apparatus, that there is fixed wave length; Described light source adopts pipe property LED, is light emitting diode semi-conductor solid-state light source, to gapless between this exiting surface surface.The silica gel of the surperficial wrapping biological tolerability of LED light source, the silica gel of bio-compatible possesses biology performance, can be because of not direct in conjunction with reducing its usefulness and service life with biosystem.Bio-compatible silicone rubber has good biocompatibility, to tissue nonirritant, avirulence, few without anaphylaxis, body rejection; Having good physicochemical property, with body fluid and organize in contact process and can keep its original elasticity and pliability, be not degraded, is a kind of inert substance of quite stable.The LED light source of wrapping biological tolerability silica gel can be high temperature resistant, can sterilize, and machine-shaping is convenient, and easily processing engraving shape, easy to use.
LED light source is comprised of a plurality of independently LED, by part, connect, whole mode in parallel, can reach the required brightness for the treatment of, can implement personalized treatment again, the different exposure rates of different parts are set according to the concrete condition in patient affected part by programme-control.The enforcement of this function also depends on body soft durometer, the cooperation of the scale of length and tube outer surface.This design selects the moderate material of soft durometer to make body, makes its misery that can enter smoothly pipeline crooked in patient body and reduce patient, and fully conduction operation person's strength takes operation to position again.The length of body, by according to the standard design of human body, also can be designed to the body of different thicknesses according to treating required exposure rate, and thinner person can consider that the mode that per nasal enters is designed to corresponding length, and thicker person can enter by per os.
Photodetector, for detection of light output situation.More specifically, photodetector is coupled in this light conductive liquid container for detection of light output situation in this light conductive liquid.
Control circuit, be coupled to this LED light source power supply unit, can adjust this LED light source brightness according to the detection signal of this photodetector, control this modulation member simultaneously, and then provide illumination for patient's first stage and the second stage for patient by illumination not, and to make illumination within the first stage be pulsed light according to or make this first stage be longer than in time all the time this second stage.This control circuit can be connected to can input command and the outer computer of data for storage data storehouse and user, therefrom receive data, these data and described first stage, second stage and relevant for frequency or the pulse of patient's first stage internal modulation in illumination.
Modulation member, under the control of described control circuit, regulates and patient's focus is carried out to the duration of illumination and the interval duration between twice illumination at every turn.Modulation member comprises pulse-width modulation circuit, the first copped wave part and the second copped wave part, in order to light modulated, shine, with the treatment circulation that provides one or more circulations to form, each circulation of wherein said a plurality of circulations comprises a second stage, and followed by first stage of second stage.Within the first stage, illumination, for patient, in second stage, is not used for to patient by illumination.This modulation member is the illumination pulsation for making to apply within each first stage also, to provide pulsed light to shine to patient.
Filter wheel, for controlling type and the wavelength through the light of this filter wheel; The type of described light comprises ultraviolet light, infrared light, visible ray.More specifically, filter wheel comprises the first filter wheel and the second filter wheel, the first filter wheel at least have one in order to ultraviolet transmissive light modulation filter element, filter element in order to transmitted infrared light, filter element in order to visible light transmissive and one in order to stop the Resistance from any light transmission of this light source.The second filter wheel has a plurality of in order to select the filter element through the specific wavelength bandwidth of this second filter wheel.Further, the first filter wheel and the second filter wheel comprise driving device, in order to rotating filtering wheel, so that selected filter element aligns with light source, and then provide the light of required wavelength.Preferably, described the second filter wheel comprises leaning device, in order to the filter wheel that tilts, so that the bandwidth being provided by each filter element of this second filter wheel is offset.
Light intensity detector, for detection of see through, pass to patient's light intensity from filter wheel, and during the treatment based on this light intensity and patient, photoconduction and patient's distance is identified for this patient's dosage.
Spectroanalysis instrument, for being received and analyzed by fibre-optic waveguide from the light of patient's affected area reflection.
Described illumination light module comprises, the first primary lights semiconductor light sources, for sending the first primary lights.The second primary lights semiconductor light sources, for sending the second primary lights.Collecting lens, is positioned in the light path of the first primary lights and the second primary lights, for converging the first primary lights and the second primary lights.Optical fiber, its one end is positioned at collecting lens focus place, and the other end connects endoscope.
Thereby adopt semiconductor laser as light source can energy efficient, the diameter that reduces to pass light path alleviate patient misery, eliminate to the unnecessary heating of illumination intraluminal tissue, reduce lighting source volume, exempt the repair and replacement to light source; Illumination light module adopts control device to carry out switch and power adjustments to primary light source, can realize color lighting, conveniently focus is observed.Transmit and compare with fibre bundle with the ordinary light source illumination of spontaneous radiation in existing endoscope, illumination light module provided by the invention brightness is high, heat is little, make endoscope's rich color true to nature, and the demand of focus is adjusted the laser output power of each laser instrument according to the observation, obtains suitable brightness, color and colourity.
Light-conducting system 3, for entering in patient body to be treated under the control of described control system, and will conduct to described illumination dioptric system 4 by described light source 1 light that import, that have fixed wave length.The main body of this light-conducting system 3 is optical fiber, it has, and side-scattered light intensity is uniformly distributed, illumination zone is wide, energy loss is little, with low cost, there is plasticity, can carry out the features such as certain bending, intracavity Uniform Illumination.Lateral emitting optical fiber claims again entirely lighting optical fiber, linear optical fiber, leakage type optical fiber, heavy caliber light pipe to be even also called as neon optical fiber etc.It can not only transfer to other end from optical fiber one end face by light, and light can also be leaked out from its cladding surface, makes optical fiber integrally luminous.
Leaded light is carried out in the main use special handling of the light-conducting system 3 evenly optical fiber of light leak.In the optical fiber of this light-conducting system 3, scattering object with different density and depth profile in the sandwich layer of sandwich layer and covering interface.When having light conducting to transmit in optical fiber, part light conducting will be scattered body and scatter to optical fiber equably from the side of optical fiber.The uniformity of optical fiber side scattered light intensity is to realize by changing the attenuation quotient at optical fiber diverse location place, and the change of attenuation quotient is to realize by changing density and the degree of depth of optical fiber diverse location place scattering object.
Control system 2, enters in patient body to be treated for controlling described light-conducting system 3, and the illumination dioptric system 4 that makes to be positioned at described light-conducting system 3 front ends arrives the affected area of patient bodies.
Illumination dioptric system 4, for being radiated at uniformly the focus in patient body by the light with fixed wave length of described light-conducting system 3 conduction.More specifically, described illumination dioptric system is led emitter surface by the light of light source by a branch of optical fiber, end at each optical fiber arranges prism, and the effect by prism makes light evenly diffuse to surrounding, arrives luminal surface/deep tissue (as shown in Figure 3); Or the end at optical fiber arranges reflectance coating, a part of light transmission is gone out, the light of another part evenly diffuses to arrival luminal surface/deep tissue; Or in emitter surface, corresponding optical channel is set, light is evenly shed by described optical channel, arrive luminal surface/deep tissue (as shown in Figure 4).
Further, the dioptric system 4 that makes the to throw light on multiple implementation that light evenly can have been shed, the present embodiment is listed wherein three kinds:
The first is to utilize light intensity to equate, as shown in Figure 5.Single led distribution curve flux is I=I0cos θ, does following hypothesis: 1, directly over each LED, the light intensity of corresponding point A is only subject to the impact of this LED and two adjacent LEDs; 2, the light intensity of the central point B of two LED top is only subject to the impact of these two LED.
If the light intensity that the A in Fig. 5, B equates, approximately think even in the light intensity of AB line direction at 2; In the direction vertical with AB line, there is identical conclusion; If the LED of both direction is in staggered distribution and while all reaching requiring that point-to-point transmission light intensity equates, think even in the light intensity of whole shadow surface.
The second is to utilize illumination to equate, as shown in Figure 5.Single led distribution curve flux I=I0cos θ, does following hypothesis: 1, directly over each LED, the illumination of corresponding point A is only subject to the impact of this LED and two adjacent LEDs; 2, the illumination of the central point B of two LED top is only subject to the impact of these two LED;
If the illumination that the A in Fig. 5 figure, B are 2 equates, the approximate uniform-illumination of thinking in AB line direction; In the direction vertical with AB line, there is identical conclusion; If the LED of both direction is in staggered distribution and while all reaching requiring that point-to-point transmission illumination equates, think even in the light intensity of whole shadow surface.
The third is direct modeling.Fig. 6 is single led simulation schematic diagram, Fig. 7 is the simulation schematic diagram of a plurality of LED, as seen from the figure, when LED quantity increases, the energy comparison that shadow surface mid portion receives under the irradiation of each LED is even, suitably adjust the spacing between LED, can make the Energy distribution of shadow surface reach a degree the most uniform.Fig. 8 is the distribution simulation schematic diagram of a plurality of LED of plane receiving plane, and as shown in the figure, the horizontal range of two LED of same row is d, with the vertical distance of two adjacent LED of string, is h.By the value of continuous adjustment d and h, and by the emulation of simulation softward, can draw a suitable d and h value, make the illuminance uniformity of receiving plane reach reasonable degree, as shown in Figure 9.
The Phototherapeutic device that the embodiment of the present invention provides can be realized and cover the light treatment of any infected zone completely, and provide the rayed of the optical density such as intimate, solve the problem that hot spot type irradiation apparatus cannot Large-Area-Uniform irradiates, the position edema that effectively reduces inflammation congested phenomenon simultaneously, improve microcirculation, promote tissue repair healing and solve drug tolerant bacteria intracavity to infect the problem that cannot effect a radical cure.The Phototherapeutic device drug treatment that the embodiment of the present invention provides is short, can predict complication low, has safety.
Referring to Figure 10, it is Phototherapeutic device provided by the invention the 3rd example structure schematic diagram.The Phototherapeutic device that the present embodiment provides, also comprise that the Phototherapeutic device that the structure of light source 1, light-conducting system 3, control system 2, illumination dioptric system 4, spectral match system 5 and above-mentioned parts and function and a upper embodiment provide is basic identical, in the present embodiment, repeat no more.The difference of the Phototherapeutic device that the Phototherapeutic device that this present embodiment provides and a upper embodiment provide is, increase some new accessory or auxiliary device, as shown in figure 11, the Phototherapeutic device that the present embodiment provides, except light source 1, light-conducting system 3, control system 2, illumination dioptric system 4, spectral match system 5, also comprises: sacculus;
Described balloon structure comprises: body 6, gastric balloon 7 and/or esophagus air bag 8; Gastric balloon 7 and/or esophagus air bag 8 are communicated with body 6 near one end of body, and body 6 is for to gastric balloon 7 and/or esophagus air bag 8 inflation/deflations, and extract esophagus liquid, gastric juice.Gastric balloon 7 and/or esophagus air bag 8, for entering after patient's cavity with Phototherapeutic device at it, make the relatively described patient's cavity of described Phototherapeutic device fix and prevent stomach, esophagus haemorrhage.
More specifically, in body 6, also have esophagus liquid extracting cavity, one end attaching in esophagus liquid extracting cavity accordingly has esophagus liquid extraction tube, and the body side contiguous with esophagus air bag 8 has esophagus liquid extraction aperture, and esophagus liquid extraction aperture, esophagus liquid extracting cavity, esophagus liquid extraction tube communicate.In the centre of stomach gas tube and the centre of esophagus gas tube, interlink respectively and be connected to stomach buffer air bag and esophagus buffer air bag, it be to there is elastic cystidium.The esophagus liquid extracting cavity increasing can be avoided causing secondary infection in secretions suction lung; Buffer air bag can directly be observed the inflation situation of stomach, esophagus air bag and adjust in time; Also be convenient to changing-over syringe; The length of esophagus air bag is 8～12 centimetres, can reduce the compressing to left bronchus and left atrium after esophagus airbag aeration, the utensil also using when preventing stomach, esophagus haemorrhage emergent.
Further, described Phototherapeutic device also comprises accessory entrance 9, for from then on mouthful entering in patient body for mate-assist therapy equipment.The device that can be used in conjunction with by accessory entrance 9 and Phototherapeutic device provided by the invention includes but not limited to: insertion system, administration injection apparatus.
Insertion system: insertion system possesses installs the first sacculus on the insertion section of endoscope, and guide described insertion section insertosome intracavity, and the insertion assistive device that possesses the second sacculus at its leading section, with to the first sacculus with the second sacculus carries out the supply of air, link the end connector there is pipeline on the balloon control apparatus of attraction.The first pipeline that insertion system is communicated with the first sacculus with being arranged on endoscope insertion part, be arranged on the second pipeline of inserting the second sacculus on assistive device and being communicated with, to the 3rd pipeline of supply of lubricant between insertion section and insertion assistive device, be attached on balloon control apparatus, or, described three pipelines are connected to and external device (ED) between endoscope adapter portion and be attached on balloon control apparatus, therefore can easily carry out and balloon control apparatus between bridging work, can eliminate link mistake simultaneously.Insertion system is by alternately inserting the insertion section of endoscope and inserting assistive device, to the deep digestive tube of small intestinal or large intestine etc., inserts and observes.
Administration injection apparatus: one end of its tube for transfusion is positioned at the bottom of reservoir, and the other end is provided with medicine shower nozzle, and the front end of described medicine shower nozzle has spherical, is provided with several spray orifices on spherical.On the bottle cap of reservoir, be plugged with gas tube, one end of gas tube is positioned at the top of reservoir liquid level, and the other end is connected with extruding gas cell.While anaesthetizing before the cervix uteri intrauterine surgical to stomach or women, medicine shower nozzle with spherical is inserted in stomach or cervix uteri uterine cavity, then by the air in extruding gas cell extruding reservoir, anesthetic liquid medicine is ejected on stomach or cervix uteri uterine cavity uniformly by the spray orifice on medicine shower nozzle, reduced patient's misery, its practicality rational in infrastructure, without particular surgical instrument, easy and simple to handle.
Further, Phototherapeutic device provided by the invention is provided with sterile isolation sleeve in endoscope.Sterile isolation sleeve is included in the outer surface of endoscope, adopt rigid plastics or lucite or glass to make, on separation sleeve, the observation port position of corresponding endoscope is the transparent body, on it, be shaped with the convex-concave circle stricture of vagina of similar optical glass, the part that separation sleeve inserts human body is all transparent bodies, on separation sleeve, the fiber bench position of corresponding cavity mirror is provided with card inserting mouth, at the transparent body position of separation sleeve inwall, is coated with antifoggant.
The Phototherapeutic device that the embodiment of the present invention provides can be realized and cover the light treatment of any infected zone completely, and provide the rayed of the optical density such as intimate, solve the problem that hot spot type irradiation apparatus cannot Large-Area-Uniform irradiates, the position edema that effectively reduces inflammation congested phenomenon simultaneously, improve microcirculation, promote tissue repair healing and solve drug tolerant bacteria intracavity to infect the problem that cannot effect a radical cure.The Phototherapeutic device drug treatment that the embodiment of the present invention provides is short, can predict complication low, has safety.
One of ordinary skill in the art will appreciate that all or part of flow process realizing in above-described embodiment method, to come the hardware that instruction is relevant to complete by computer program, described program can be stored in a computer read/write memory medium, this program, when carrying out, can comprise as the flow process of the embodiment of above-mentioned each side method.Wherein, described storage medium can be magnetic disc, CD, read-only store-memory body (Read-Only Memory, ROM) or random store-memory body (Random AccessMemory, RAM) etc.
Above disclosed is only a kind of preferred embodiment of the present invention, certainly can not limit with this interest field of the present invention, and the equivalent variations of therefore doing according to the claims in the present invention, still belongs to the scope that the present invention is contained.
Claims (2)
1. a Phototherapeutic device, is characterized in that, comprising: light source, control system, light-conducting system and illumination dioptric system;
Light source, conducts in described light-conducting system for having the light of fixed wave length to the conduction of described light-conducting system, comprise to receive from filtering apparatus and the light that has the light of fixed wave length and this is had to fixed wave length;
Light-conducting system, for entering in patient body to be treated under the control of described control system, and by by described light source, light that import, that have fixed wave length conducts to described illumination dioptric system;
Control system, enters in patient body to be treated for controlling described light-conducting system, and the illumination dioptric system that makes to be positioned at described light-conducting system front end arrives the affected area of patient body;
Illumination dioptric system, for the light with fixed wave length of described light-conducting system conduction is radiated to the focus in patient body uniformly, described illumination dioptric system is led emitter surface by the light of light source by a branch of optical fiber, end at each optical fiber arranges prism, effect by prism makes light evenly diffuse to surrounding, arrives luminal surface or deep tissue; Or the end at optical fiber arranges reflectance coating, a part of light transmission is gone out, the light of another part evenly diffuses to and arrives luminal surface or deep tissue; Or in emitter surface, corresponding optical channel is set, light is evenly shed by described optical channel, arrive luminal surface or deep tissue.
2. the Phototherapeutic device as described in claim 1, is characterized in that, described Phototherapeutic device also comprises:
Spectral match system, for selecting the spectrum of different wave length to match colors according to patient's focus, kills the bacterium of curing the disease of affected area as radiation source, the wave-length coverage of described spectrum comprises: 360nm to 420nm.
3. the Phototherapeutic device as described in claim 1, is characterized in that, described light source comprises: illumination light module and treatment optical module;
Illumination light module, is used to the endoscope of described Phototherapeutic device front end that illumination is provided;
Treatment optical module, for having light fixed wave length, that be used for the treatment of patient body inner disease foci to described light-conducting system conduction.
4. the Phototherapeutic device as described in claim 3, is characterized in that, described treatment optical module comprises:
LED light source, for generation of or receive from light this filtering apparatus, that there is fixed wave length; Described light source adopts pipe property LED;
Photodetector, for detection of light output situation;
Control circuit, is coupled to the power supply unit of described LED light source, for adjust the brightness of described LED light source and the work of controlling modulation member according to the detection signal of described photodetector;
Modulation member, under the control of described control circuit, regulates and patient's focus is carried out to the duration of illumination and the interval duration between twice illumination at every turn;
Filter wheel, for controlling type and the wavelength through the light of this filter wheel; The type of described light comprises ultraviolet light, infrared light, visible ray;
Light intensity detector, for detection of seeing through, pass to patient's light intensity from filter wheel, and is identified for this patient's dosage based on this light intensity;
Spectroanalysis instrument, for receiving and analyze from the light of patient's affected area reflection.
5. the Phototherapeutic device as described in claim 3, is characterized in that, described illumination light module comprises:
The first primary lights semiconductor light sources, for sending the first primary lights;
The second primary lights semiconductor light sources, for sending the second primary lights;
Collecting lens, is positioned in the light path of the first primary lights and the second primary lights, for converging the first primary lights and the second primary lights; Optical fiber, its one end is positioned at collecting lens focus place, and the other end connects endoscope.
6. Phototherapeutic device as claimed in claim 1, is characterized in that, described Phototherapeutic device also comprises: sacculus; Described balloon structure comprises: body, gastric balloon and/or esophagus air bag; Gastric balloon and/or esophagus air bag are communicated with body near one end of body, and body is used for to gastric balloon and/or esophagus airbag aeration or venting, and extract esophagus liquid, gastric juice;
Gastric balloon and/or esophagus air bag, for entering after patient's cavity with Phototherapeutic device at it, make the relatively described patient's cavity of described Phototherapeutic device fix and prevent stomach, esophagus haemorrhage.
7. the Phototherapeutic device as described in claim 6, is characterized in that, the length of described esophagus air bag is 8～12 centimetres.
8. the Phototherapeutic device as described in claim 7, is characterized in that, described Phototherapeutic device also comprises accessory entrance, for for mate-assist therapy equipment from then on accessory entrance enter in patient body.
9. the Phototherapeutic device as described in any one in claim 1 to 5, is characterized in that, described Phototherapeutic device enters in patient body by patient's oral cavity or nasal cavity.
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| CN201210053425.XA CN102553084B (en) | 2012-03-02 | 2012-03-02 | Phototherapy device |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9949889B2 (en) * | 2013-11-11 | 2018-04-24 | Joylux, Inc. | At-home light-emitting diode and massage device for vaginal rejuvenation |
| US10179085B2 (en) | 2015-10-02 | 2019-01-15 | Joylux, Inc. | Light-emitting diode and massage device for delivering focused light for vaginal rejuvenation |
| JP6498654B2 (en) * | 2016-11-17 | 2019-04-10 | 一般財団法人バイオダイナミックス研究所 | Light irradiation probe for light irradiation treatment by endoscope |
| CN107224671B (en) * | 2017-06-09 | 2023-07-18 | 深圳市美的连医疗电子股份有限公司 | Cavity therapeutic apparatus |
| CN107982641A (en) * | 2017-12-06 | 2018-05-04 | 张艾丽 | A kind of light pipe for being exclusively used in neonate and intervening phototherapy |
| CN107970525A (en) * | 2017-12-06 | 2018-05-01 | 刘承佳 | A kind of insertion type Neonatal jaundice phototherapy instrument |
| CN108635678B (en) * | 2018-08-02 | 2023-06-27 | 夏云程 | Light guide structure, light emitting device, therapeutic instrument, beauty mask and comprehensive treatment system |
| CN111388873A (en) * | 2020-03-26 | 2020-07-10 | 苏州科技城医院 | Gastric cavity phototherapy sterilization device and method based on blue light L ED |
| CN112402807B (en) * | 2020-11-18 | 2021-11-23 | 中国人民解放军总医院 | Photodynamic therapeutic apparatus for human body cavity and cavity organ |
| CN116139415B (en) * | 2023-02-20 | 2024-01-26 | 广东国志激光技术有限公司 | Phototherapy system and phototherapy capsule |
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| CN1098018A (en) * | 1993-07-26 | 1995-02-01 | 田洪涛 | Light guide therapy apparatus |
| CN201370899Y (en) * | 2009-01-19 | 2009-12-30 | 深圳市微创医学科技有限公司 | Optical fiber output LED photodynamic therapy device |
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