CN111388873A - Gastric cavity phototherapy sterilization device and method based on blue light L ED - Google Patents
Gastric cavity phototherapy sterilization device and method based on blue light L ED Download PDFInfo
- Publication number
- CN111388873A CN111388873A CN202010224382.1A CN202010224382A CN111388873A CN 111388873 A CN111388873 A CN 111388873A CN 202010224382 A CN202010224382 A CN 202010224382A CN 111388873 A CN111388873 A CN 111388873A
- Authority
- CN
- China
- Prior art keywords
- catheter
- blue light
- phototherapy
- light source
- balloon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0624—Apparatus adapted for a specific treatment for eliminating microbes, germs, bacteria on or in the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0609—Stomach and/or esophagus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
- A61N2005/0651—Diodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Abstract
The invention discloses a phototherapy sterilization device and a phototherapy sterilization method for a gastric cavity based on blue light L ED, wherein the device comprises a hose, at least one air bag catheter and a light source catheter, wherein the at least one air bag surrounds the outside of the hose and is in sealed connection with the hose, an inflation port corresponding to each air bag is arranged on the wall of the hose, the at least one air bag catheter is arranged in the hose and extends along the hose, one end of each air bag catheter is only communicated with the inflation port corresponding to each air bag, the other end of each air bag catheter is connected with an inflation device, the light source catheter is arranged in the hose and extends to the tail end of the hose along the hose and is communicated with the gastric cavity, the blue light L ED is arranged in the light source catheter through a guide wire and is located in the space of the at least one air bag.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a gastric cavity phototherapy sterilization device and method based on blue light L ED.
Background
Helicobacter pylori (Hp) is a gram-negative microaerophilic bacterium, colonizes the gastric and duodenal mucosa of humans, and is the only bacterium found in humans that survives in the stomach. China is a high incidence area of Hp infection, and the incidence rate tends to rise year by year. Survey data shows that the detection rate of Hp in adults in China reaches 30% -80%, and people infected with Hp have obvious regional, economic, life habit and occupational differences. The infection of Hp is the cause of peptic ulcer, gastric cancer and other diseases, and in the 90 s of the 20 th century, the international agency for research on cancer defines Hp as a class I carcinogenic factor of gastric cancer. Hp is mainly transmitted through human-to-human 'fecal-oral', 'oral-oral' and 'gastric-oral' routes, and research shows that the existence of Hp can be detected in saliva, vomitus regurgitation and dental plaque.
The form of Hp is spiral or arc-shaped, 2-6 flagella are arranged at one end of the thallus, the thallus penetrates through a mucus layer through the movement of the flagella after entering the stomach, and is fixedly planted at the fovea and epithelial fold positions through secreted adhesins and cannot be discharged out of the body along with excrement. In addition, the secreted urease can hydrolyze urea to produce ammonia, neutralize gastric acid and form a protective shell around Hp, so that the urea can survive in the strong acid environment in the stomach. Hp is a intractable pathogenic bacterium, and patients cannot spontaneously clear after infection, and the current main treatment mode depends on various antibiotics, such as clarithromycin, metronidazole and the like serving as antibacterial agents. However, in recent years, the rate of eradication of Hp has been gradually reduced due to the increasing drug resistance of antibacterial agents, and for example, the success rate of drug-resistant strains of clarithromycin in curative treatment of Hp is only 30%. Meanwhile, Hp treatment with antibiotics leads to some side effects inevitably as well as increase in the drug resistance rate of antibacterial drugs.
With the development of medical technology and the popularization of endoscopic treatment, physical therapy becomes a new means for treating digestive tract diseases, and researches show that ultraviolet light can kill helicobacter pylori cultured in vitro, has good bactericidal effect on clarithromycin-resistant helicobacter pylori, and has toxic and side effects on normal cells. In recent years, blue light is widely applied clinically by virtue of the advantages of high bundling property, controllable energy, high safety and the like, and the blue light photodynamic sterilization method provides a possibility of replacing the traditional medicine to eradicate Hp. The blue light is visible light with the wavelength of 375-480nm, and after the bacteria are irradiated, the energy transfer is generated by the action of endogenous porphyrin which generates active oxygen and excites the endogenous porphyrin of the bacteria and receives photons and oxygen molecules, so that the active oxides such as singlet oxidation hydroxyl free radicals and the like with cytotoxicity are generated, and the proteins, the lipids, the nucleic acids and the like are damaged to generate the bactericidal effect. Unlike ultraviolet photodynamic sterilizing method, blue light sterilizing method has no obvious toxic side effect on normal tissue cell.
The present method for killing helicobacter pylori in stomach cavity by blue light mainly comprises two modes, 1, guiding the blue light source to be placed in the stomach cavity by an endoscope, and irradiating the stomach cavity by adjusting the output power of the blue light source, research results show that the clearance rate of the helicobacter pylori in antrum is highest and reaches 97%, secondly, the stomach body is 95%, and the clearance rate of the fundus is only 86%.
Therefore, there is a need to provide a new device and method for killing helicobacter pylori in the stomach cavity by using blue light to solve the above problems.
Disclosure of Invention
In order to solve the defects of the prior art, the invention aims to provide a novel phototherapy sterilization device and a novel phototherapy sterilization method for a stomach cavity based on blue light L ED, wherein the phototherapy device combining the blue light L ED and an air bag is placed in the stomach cavity, the air bag is inflated in vitro to expand the stomach, so that the stomach wall is fully exposed, and L ED in the air bag emits blue light, so that the best effect of phototherapy Hp in the stomach is achieved.
In order to achieve the above purpose, the embodiment of the present invention provides the following specific technical solutions:
in a first aspect, a blue light L ED based gastric cavity phototherapy sterilization device is provided, the device comprising:
a hose;
the at least one air bag surrounds the outer side of the hose and is connected with the hose in a sealing mode, and an inflation port corresponding to each air bag is arranged on the wall of the hose;
the at least one air bag conduit is arranged in the hose and extends along the hose, one end of each air bag conduit is only communicated with the corresponding inflation port of one air bag, and the other end of each air bag conduit is connected with an inflation device;
the light source catheter is arranged in the hose, extends to the tail end of the hose along the hose and is communicated with the gastric cavity, and the blue light L ED is arranged in the light source catheter through a guide wire and is positioned in the space of the at least one air bag.
Furthermore, one end of the light source catheter communicated with the outside is connected with a gastric juice detection device.
Further, the gastric juice detecting device is an air-filling/liquid-pumping device, such as a medical syringe.
Further, the at least one bladder is disposed proximate the hose end.
Further, the placement of the blue light L ED within the light source catheter by a guidewire includes securing the blue light L ED to the guidewire and placing the guidewire within the light source catheter.
Further, at least one gasbag is two gasbags, two gasbags set up in proper order at the interval in being close to the position of hose end, at least one gasbag pipe is two gasbag pipes, and every gasbag pipe communicates with the corresponding inflation inlet of a gasbag respectively.
Further, the placement of the blue light L ED in the light source catheter through the guide wire comprises the steps of fixing two blue light L ED on the guide wire at intervals, wherein the intervals are consistent with the intervals of the two air bags, and placing the blue light L ED in the light source catheter through the guide wire in a guiding mode.
Furthermore, the distance between the nearest inflation inlet and the tail end of the hose is 4-6 cm, and the distance between every two adjacent inflation inlets is 10-12 cm.
Further, the material of the hose, the balloon catheter and the light source catheter is a high-light-transmittance material and/or an acid-resistant and corrosion-resistant material, and is preferably polyurethane.
In a second aspect, there is provided an improved blue light L ED based gastric cavity phototherapy sterilization device, the device comprising:
at least one balloon catheter;
the light source catheter and the at least one air bag catheter are integrally cast to form a parallel tube bundle structure;
at least one air bag surrounding the outside of the tube bundle structure and connected with the tube bundle structure in a sealing manner;
one end of each balloon catheter in the at least one balloon catheter is connected with only one balloon in the at least one balloon, and the other end of each balloon catheter is connected with an inflating device;
the tail end of the light source catheter is communicated with the gastric cavity, and the blue light L ED is placed in the light source catheter through a guide wire and is positioned in the space of the at least one air bag.
Furthermore, one end of the light source catheter communicated with the outside is connected with a gastric juice detection device.
Further, the gastric juice detecting device is an air-filling/liquid-pumping device, such as a medical syringe.
Further, the at least one balloon is disposed proximate the light source catheter tip.
Further, the placement of the blue light L ED within the light source catheter by a guidewire includes securing the blue light L ED to the guidewire and placing the guidewire within the light source catheter.
Further, the at least one air bag is two air bags, the two air bags are sequentially arranged at the position close to the tail end of the light source catheter at intervals, the at least one air bag catheter is two air bag catheters, and the two air bag catheters are respectively communicated with the two air bags.
Further, the placement of the blue light L ED in the light source catheter through the guide wire comprises the steps of fixing two blue light L ED on the guide wire at intervals, wherein the intervals are consistent with the intervals of the two air bags, and placing the blue light L ED in the light source catheter through the guide wire in a guiding mode.
Furthermore, the distance between the outlet end of the balloon catheter closest to the tail end of the light source catheter and the tail end of the light source catheter is 4-6 cm, and the distance between the outlet ends of two adjacent balloon catheters is 10-12 cm.
Further, the material of the balloon, the balloon catheter and the light source catheter is a high-light-transmittance material and/or an acid-resistant and corrosion-resistant material, and is preferably polyurethane.
In a third aspect, a therapeutic method using the phototherapy sterilization device for gastric cavity is provided, the method comprises the following steps:
under the guidance of a guide wire in the light source catheter, after the phototherapy sterilization device for the gastric cavity is placed in the gastric cavity, the position of the phototherapy sterilization device for the gastric cavity is detected through a gastric juice detection device which is connected with one end, communicated with the outside, of the light source catheter;
when the detection result is that the light source catheter is communicated with gastric juice, the inflating device inflates the balloon through the balloon catheter;
when the inflation amount reaches the set value that the stomach wall is fully exposed, the inflation is stopped, and the blue light L ED inside the air bag space is subjected to phototherapy sterilization.
Further, the gastric juice detecting device is an air-filling/liquid-pumping device, such as a medical syringe.
Further, the detection result is that the light source catheter comprises, before communicating with gastric juice: all of the balloons are determined to be located within the gastric cavity.
Further, said determining that all of said balloons are located within the gastric cavity comprises: through the surface mark size scale at stomach chamber phototherapy sterilizing equipment, work as the terminal internal size that gets into of stomach chamber phototherapy sterilizing equipment is more than 65cm, confirms all promptly the gasbag is located the stomach intracavity.
Further, the total length of the phototherapy sterilization device for the gastric cavity is about 120cm, 4 size scales are marked on the outer surface of the phototherapy sterilization device for the gastric cavity, and the first scale is 45cm, which indicates that the tail end of the phototherapy sterilization device for the gastric cavity reaches the cardia; the second scale is 55cm, which indicates that the tail end of the phototherapy sterilization device of the gastric cavity enters the stomach body; the third scale is 65cm, which indicates that the tail end of the phototherapy sterilization device for the gastric cavity enters the pylorus; the fourth scale is 75cm, which indicates that the tail end of the phototherapy sterilization device for the gastric cavity enters the duodenum.
Further, the inflation device is an inflator or a manual pumping device.
Further, the set value range of the aeration quantity is 1000m L-1500 m L.
Furthermore, the wavelength of the blue light emitted by the blue light L ED is 375-480nm, preferably 375-425 nm, and most preferably 405-410 nm.
The technical scheme provided by the embodiment of the invention has the following beneficial effects:
1. the phototherapy sterilization device for the stomach cavity based on the blue light L ED is simple and convenient in structure, easy to operate, high in repeated utilization rate and good in sterilization effect, the sterilization effect of the stomach fundus and the large bent part of the stomach body close to the stomach fundus is obviously improved, the undesirable sterilization effect is achieved by using the blue light source, and the better sterilization effect can be guaranteed by controlling the irradiation dose of the blue light;
2. the phototherapy sterilization method for the gastric cavity based on the blue light L ED is simple and safe to operate and convenient to control, and avoids the increase of the drug resistance rate of antibacterial drugs and side effects on human bodies caused by treatment with antibiotic drugs and the toxic and side effects on normal cells caused by ultraviolet sterilization treatment.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required to be used in the description of the embodiments are briefly introduced below, the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings may be obtained according to the drawings without creative efforts.
FIG. 1 is a block diagram illustrating a blue light L ED based gastric cavity phototherapy sterilization device according to an exemplary embodiment;
FIG. 2 is a block diagram illustrating a blue light L ED based gastric cavity phototherapy sterilization device according to another exemplary embodiment;
FIG. 3 is a block diagram illustrating an improved blue light L ED based gastric cavity phototherapy sterilization device, according to an exemplary embodiment;
FIG. 4 is a schematic diagram illustrating the operation of a blue light L ED based gastric cavity phototherapy sterilization device according to an exemplary embodiment;
fig. 5 is a flow diagram illustrating a method of phototherapy sterilization of a gastric cavity based on blue light L ED, according to an exemplary embodiment.
The gastric juice detecting and inflating device comprises 1-blue light L ED, 1 a-first blue light L ED, 1 b-second blue light L ED, 2-air bags, 2 a-first air bags, 2 b-second air bags, 3-hoses, 4-air bag catheters, 4 a-first air bag catheters, 4 b-second air bag catheters, 5-light source catheters, 6-gastric juice detecting devices and 7-inflating devices.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
The phototherapy sterilization device and the phototherapy sterilization method for the gastric cavity based on the blue light L ED provided by the embodiment of the invention have the advantages that the sterilization effect which is not ideal when the fundus and the body of the stomach are bent to be close to the fundus in the prior art is obviously improved, and no side effect is brought to the human body.
Fig. 1 is a structural diagram of a phototherapy sterilization device for gastric cavity based on blue light L ED according to an exemplary embodiment, as shown in fig. 1, as a preferred embodiment, in an embodiment of the present invention, the phototherapy sterilization device for gastric cavity based on blue light L ED includes a flexible tube 3, a balloon 2 surrounding the flexible tube 3 and hermetically connected to the flexible tube, the sealing may be achieved by using a sealing tape, a sealing glue or a casting method, an inflation port corresponding to the balloon 2 is provided on a wall of the flexible tube 3, the balloon 2 is close to a distal end of the flexible tube 3, a measurement distance from the inflation port to a distal end of the flexible tube is about 4-6 cm, the balloon catheter 4 is disposed inside the flexible tube 3 and extends along the flexible tube, one end of the balloon catheter 4 is connected to the inflation port in a manner of extending outside the flexible tube 3 through the inflation port, further, in order to ensure an inflation effect, a connection between the inflation port and the balloon catheter may be sealed, the other end of the balloon catheter 4 is connected to an inflation device 7, a light source catheter 5, the flexible tube 3 is disposed inside the flexible tube 3, the flexible tube is connected to a catheter 3, and is connected to a light source device, and is connected to a catheter 35, and is connected to the light source device, preferably, the light source device is connected to the light source device, the light source is connected to the light source device, the flexible tube, the light source is connected to the catheter 3, the light source is connected to the catheter 3.
Fig. 2 is a structural diagram of a gastric cavity phototherapy sterilization device based on blue light L ED according to another exemplary embodiment, referring to fig. 2, as a preferred embodiment, in an embodiment of the present invention, the gastric cavity phototherapy sterilization device based on blue light L ED includes a hose 3, a first balloon 2a and a second balloon 2b, the first balloon 2a and the second balloon 2b surround the outside of the hose 3 and are connected to the hose in a sealing manner, the sealing manner may be implemented by using a sealing tape, a sealing glue or a casting integral, inflation ports corresponding to the first balloon 2a and the second balloon 2b are provided on a wall of the hose 3, the first balloon 2a and the second balloon 2b are close to a distal end of the hose 3, an inflation port corresponding to the second balloon 2b is 4-6 cm from a distal end of the hose, a distance between two inflation ports corresponding to the first balloon 2a and the second balloon 2b is 10-12 cm, the first balloon catheter 4a and the second balloon catheter 4b, the first balloon catheter 4a and the second balloon 4b are disposed inside the catheter tube, the catheter 4a catheter 3 b and a catheter 2b is connected to the catheter 3, the catheter 3 b, the catheter 3 a catheter 3 b, the catheter 3 b is connected to the catheter 3 b, the catheter 3 b is connected to the catheter 3, the catheter 3 b, the catheter 3 b, the catheter is connected to the catheter 3 b, the catheter 3 b is connected to the catheter 3, the catheter 3 b is connected to the catheter 3 b, the catheter 3, the catheter is connected to the catheter 3, the catheter 3 b, the catheter 3, the catheter is connected to the catheter 3.
Fig. 3 is a structural diagram of an improved gastric cavity phototherapy sterilization device based on blue light L ED according to an exemplary embodiment, referring to fig. 3, as a preferred embodiment, in an embodiment of the present invention, the gastric cavity phototherapy sterilization device based on blue light L ED includes a first balloon catheter 4a and a second balloon catheter 4b, a light source catheter 5, the light source catheter 5 and the first balloon catheter 4a and the second balloon catheter 4b are integrally molded to form a parallel tube bundle structure, a first balloon 2a and a second balloon 2b, the first balloon 2a and the second balloon 2b surround the parallel tube bundle structure and are hermetically connected to the parallel tube bundle structure, the sealing is performed by using sealing tape, sealing glue or integrally molded, the first balloon 2a and the second balloon 2b are sequentially spaced and disposed near the end of the light source catheter 5, one end of the first balloon catheter 4a is connected to the first balloon 2a, the other end of the first balloon catheter 4a is connected to an inflation device 7, one end of the second balloon catheter 4b is connected to the second balloon catheter 7, the light source catheter 357 a distance between the light source catheter 4a light source catheter 12 and a light source catheter 35 b, the light source catheter 2b is preferably connected to the blue light source catheter 3, the light source catheter 4a high-resistant catheter 5 is connected to the light source catheter 3, the light source catheter 3 b, the catheter is connected to the catheter 3, the catheter 2b, the light source catheter is connected to the catheter 3, the catheter is connected to the catheter 2b, the catheter is connected to the catheter, the catheter is connected to the catheter 2b, the catheter is connected to the catheter, the catheter 3, the catheter is connected to the catheter, the catheter is connected to the catheter.
Fig. 4 is a schematic diagram illustrating an operating state of a phototherapy sterilization device based on blue light L ED for a gastric cavity according to an exemplary embodiment, and referring to fig. 4, the phototherapy sterilization device based on blue light L ED for a gastric cavity employs two airbags and two blue light L ED structures, and by inflating the two airbags respectively, corresponding stomach body and stomach fundus portion are inflated, so that a stomach wall in the gastric cavity is fully exposed, and two corresponding blue light L ED in the two airbag spaces emit blue light, thereby achieving the best effect of phototherapy sterilization in the stomach.
Fig. 5 is a flowchart illustrating a phototherapy sterilization method for a gastric cavity based on blue light L ED according to an exemplary embodiment, and referring to fig. 5, the phototherapy sterilization method for a gastric cavity based on blue light L ED includes that after the phototherapy sterilization device for a gastric cavity is placed in the gastric cavity under the guidance of a guide wire in a light source catheter, the position of the phototherapy sterilization device for a gastric cavity is detected through a gastric juice detection device connected to one end of the light source catheter, which is communicated with the outside, when the detection result is that the light source catheter is communicated with gastric juice, an inflation device inflates an airbag through an airbag catheter, when the inflation amount reaches a set value at which the gastric wall is fully exposed, inflation is stopped, and phototherapy sterilization is performed on blue light ED L ED in the space of the airbag.
In particular, the gastric juice detecting device is an inflation/aspiration device, such as a medical syringe.
Specifically, the detection result is that the light source catheter comprises the following components before communicating with gastric juice: all balloons were determined to be located within the stomach cavity.
Specifically, determining that all balloons are located within the gastric cavity includes: through marking the size scale on the outer surface of the phototherapy sterilizing device for the gastric cavity, when the tail end of the phototherapy sterilizing device for the gastric cavity enters the body, the size is more than 65cm, and all air bags are determined to be located in the gastric cavity.
Specifically, the total length of the phototherapy sterilization device for the gastric cavity is about 120cm, 4 size scales are marked on the outer surface of the phototherapy sterilization device for the gastric cavity, the first scale is 45cm, and the fact that the tail end of the phototherapy sterilization device for the gastric cavity reaches the cardia is shown; the second scale is 55cm, which indicates that the tail end of the phototherapy sterilization device of the gastric cavity enters the stomach body; the third scale is 65cm, which indicates that the tail end of the phototherapy sterilization device of the gastric cavity enters the pylorus; the fourth scale is 75cm, which indicates that the tail end of the phototherapy sterilization device of the gastric cavity enters the duodenum.
Specifically, the inflation device is an inflator or a manual pumping device.
Specifically, the set value range of the inflation amount is 1000m L-1500 m L.
Specifically, the wavelength of blue light emitted by the blue light L ED is 375-480nm, preferably 375-425 nm, and most preferably 405-410 nm.
Animal experiments:
selecting 405nm blue light as an irradiation light source, and irradiating helicobacter pylori suspension (2x10ul) cultured in vitro for 20s, 40s, 80s, 160s and 320s respectively, wherein the corresponding irradiation energy is 4J/cm2, 16J/cm2 and 32J/cm2 respectively. The results suggest that 405nm blue light has bactericidal effect on H.pylori strain, and the bactericidal effect is best when the 32J/cm2 is irradiated for 320s, and then we select 405nm blue light for the next animal experiment.
Selecting 60 successfully molded rats infected by helicobacter pylori, randomly dividing the rats into 2 groups, and respectively irradiating the gastric cavity by using a blue light source with an air sac and a common blue light source, wherein the blue light is 405nm, the irradiation energy is 40J/cm2, and the irradiation time is 10 min. After irradiation, the gastric antrum, the stomach body and the gastric fundus mucosa are respectively selected for rapid urease test, and negative results show that helicobacter pylori is successfully eliminated, otherwise, the negative results fail.
The experimental results are shown in the table below, and the clearance of the blue light source with a balloon in the parts with rich folds of the stomach body and the fundus is obviously higher than that of the common blue light source, while the clearance of the blue light source in the smooth parts of the antrum of the stomach is not obviously different.
The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, however, as long as there is no contradiction between the combinations of the technical features, the scope of the present description should be considered as being described in the present specification.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. A phototherapy sterilization device based on blue light L ED for gastric cavity, the device comprising:
a hose;
the at least one air bag surrounds the outer side of the hose and is connected with the hose in a sealing mode, and an inflation port corresponding to each air bag is arranged on the wall of the hose;
the at least one air bag conduit is arranged in the hose and extends along the hose, one end of each air bag conduit is only communicated with the corresponding inflation port of one air bag, and the other end of each air bag conduit is connected with an inflation device;
the light source catheter is arranged in the hose, extends to the tail end of the hose along the hose and is communicated with the gastric cavity, and the blue light L ED is arranged in the light source catheter through a guide wire and is positioned in the space of the at least one air bag.
2. The phototherapy blue-light L ED-based gastric cavity sterilization device as claimed in claim 1, wherein a gastric juice detection device is connected to the end of the light source catheter communicating with the outside.
3. The blue light L ED-based phototherapy sterilization device for the stomach cavity of claim 1, wherein the at least one balloon is disposed near the end of the tube.
4. The blue light L ED-based gastric cavity phototherapy sterilization device according to one of claims 1-3, wherein the blue light L ED is placed in the light source catheter by a guide wire, including fixing the blue light L ED on the guide wire and placing the guide wire in the light source catheter.
5. The phototherapy blue light L ED-based gastric cavity sterilization device as claimed in one of claims 1-3, wherein the at least one balloon is two balloons, the two balloons are sequentially spaced apart from each other at a position near the end of the tube, the at least one balloon catheter is two balloon catheters, and each balloon catheter is respectively communicated with an inflation port corresponding to one balloon.
6. The blue light L ED-based phototherapy sterilization device for stomach cavity as claimed in claim 5, wherein the placement of the blue light L ED in the light source catheter through a guide wire comprises fixing two blue light L ED spaced apart on the guide wire with a distance consistent with the distance between the two balloons and placing the two blue light L ED in the light source catheter through guide wire guidance.
7. The blue-light L ED-based phototherapy sterilization device for stomach cavity according to claim 5, wherein the nearest inflation port is 4-6 cm away from the end of the hose, and the distance between two adjacent inflation ports is 10-12 cm.
8. The blue light L ED-based phototherapy sterilization device for gastric cavity as claimed in claim 1, wherein the material of the flexible tube, the balloon catheter and the light source catheter is a high light transmittance material and/or an acid and corrosion resistant material, preferably polyurethane.
9. A phototherapy sterilization device based on blue light L ED for gastric cavity, the device comprising:
at least one balloon catheter;
the light source catheter and the at least one air bag catheter are integrally cast to form a parallel tube bundle structure;
at least one air bag surrounding the outside of the tube bundle structure and connected with the tube bundle structure in a sealing manner;
one end of each balloon catheter in the at least one balloon catheter is connected with only one balloon in the at least one balloon, and the other end of each balloon catheter is connected with an inflating device;
the tail end of the light source catheter is communicated with the gastric cavity, and the blue light L ED is placed in the light source catheter through a guide wire and is positioned in the space of the at least one air bag.
10. A method of treatment using a blue light L ED based gastric cavity phototherapy sterilization device according to one of claims 1-9, the method comprising the steps of:
under the guidance of a guide wire in the light source catheter, after the phototherapy sterilization device for the gastric cavity is placed in the gastric cavity, the position of the phototherapy sterilization device for the gastric cavity is detected through a gastric juice detection device which is connected with one end, communicated with the outside, of the light source catheter;
when the detection result is that the light source catheter is communicated with gastric juice, the inflating device inflates the balloon through the balloon catheter;
when the inflation amount reaches the set value that the stomach wall is fully exposed, the inflation is stopped, and the blue light L ED inside the air bag space is subjected to phototherapy sterilization.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010224382.1A CN111388873A (en) | 2020-03-26 | 2020-03-26 | Gastric cavity phototherapy sterilization device and method based on blue light L ED |
| CN202211272456.4A CN115607844A (en) | 2020-03-26 | 2020-03-26 | Gastric cavity phototherapy sterilization device and method based on blue light LED |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010224382.1A CN111388873A (en) | 2020-03-26 | 2020-03-26 | Gastric cavity phototherapy sterilization device and method based on blue light L ED |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211272456.4A Division CN115607844A (en) | 2020-03-26 | 2020-03-26 | Gastric cavity phototherapy sterilization device and method based on blue light LED |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111388873A true CN111388873A (en) | 2020-07-10 |
Family
ID=71416520
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211272456.4A Pending CN115607844A (en) | 2020-03-26 | 2020-03-26 | Gastric cavity phototherapy sterilization device and method based on blue light LED |
| CN202010224382.1A Pending CN111388873A (en) | 2020-03-26 | 2020-03-26 | Gastric cavity phototherapy sterilization device and method based on blue light L ED |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202211272456.4A Pending CN115607844A (en) | 2020-03-26 | 2020-03-26 | Gastric cavity phototherapy sterilization device and method based on blue light LED |
Country Status (1)
| Country | Link |
|---|---|
| CN (2) | CN115607844A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1496994A2 (en) * | 2002-04-02 | 2005-01-19 | Lumerx, Inc. | Apparatus and methods using visible light for debilitating and/or killing microorganisms within the body |
| CN102553084A (en) * | 2012-03-02 | 2012-07-11 | 中山大学 | Phototherapy device |
| CN103687646A (en) * | 2011-03-17 | 2014-03-26 | 基文影像公司 | Capsule phototherapy |
| CN108778413A (en) * | 2015-12-18 | 2018-11-09 | 光治疗Asa公司 | Optical power therapentic equipment |
| CN208448271U (en) * | 2017-12-19 | 2019-02-01 | 董洁 | A kind of Gastroenterology dept.'s gastric lavage apparatus |
| CN209018684U (en) * | 2018-07-17 | 2019-06-25 | 公安县人民医院 | A kind of gastrocopy device |
-
2020
- 2020-03-26 CN CN202211272456.4A patent/CN115607844A/en active Pending
- 2020-03-26 CN CN202010224382.1A patent/CN111388873A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1496994A2 (en) * | 2002-04-02 | 2005-01-19 | Lumerx, Inc. | Apparatus and methods using visible light for debilitating and/or killing microorganisms within the body |
| CN103687646A (en) * | 2011-03-17 | 2014-03-26 | 基文影像公司 | Capsule phototherapy |
| CN102553084A (en) * | 2012-03-02 | 2012-07-11 | 中山大学 | Phototherapy device |
| CN108778413A (en) * | 2015-12-18 | 2018-11-09 | 光治疗Asa公司 | Optical power therapentic equipment |
| CN208448271U (en) * | 2017-12-19 | 2019-02-01 | 董洁 | A kind of Gastroenterology dept.'s gastric lavage apparatus |
| CN209018684U (en) * | 2018-07-17 | 2019-06-25 | 公安县人民医院 | A kind of gastrocopy device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN115607844A (en) | 2023-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US20200346032A1 (en) | Internal ultraviolet therapy | |
| JP6108410B2 (en) | Esophageal stimulation device and method | |
| US20230302292A1 (en) | Internal ultraviolet therapy | |
| DE60120569D1 (en) | CATHETER FOR ADMINISTERING RADIATION | |
| JP2009535116A (en) | Optical wand and balloon catheter | |
| US20140378873A1 (en) | Methods, devices and systems for increasing the effectiveness of ultrasound and other tissue treatment modalities | |
| CN111388873A (en) | Gastric cavity phototherapy sterilization device and method based on blue light L ED | |
| CN107174726B (en) | Implantable chemotherapy infusion system for treating bladder cancer | |
| CN109044387A (en) | A kind of three chamber angiography catheters that can show esophageal lesion | |
| KR102213647B1 (en) | Endo tracheal tube capable of treating trachea and trachea treatment system using the endo tracheal tube | |
| CN213048301U (en) | Bending adjustable stomach catheter | |
| CN100484589C (en) | Photo-hydrogen ionization therapeutical apparatus for treating skin and reproductive organ inflammation | |
| JP3734763B2 (en) | Resuscitation tube | |
| US20150073334A1 (en) | Therapeutic device for administration of aerosol | |
| CN205411793U (en) | Critical patients drainage device that defecates | |
| RU2731312C2 (en) | Method for prevention of infectious damage of vocal prostheses in patients after laryngectomy | |
| RU122871U1 (en) | DEVICE FOR SELECTIVE TREATMENT FOR Erosive-ulcerative benign diseases of the esophagus, stomach and duodenum | |
| CN213788931U (en) | Nutrition conveying device | |
| CN2562763Y (en) | Ozone therapeutical instrument | |
| JP3022341B2 (en) | Cow breast ozone infusion device | |
| CN1478449A (en) | Ozone therapeutic apparatus | |
| SU1222281A1 (en) | Arrangement for treating burns of esophagus | |
| SU1456163A1 (en) | Method of fixing probe in organ cavity | |
| CN2266429Y (en) | Decompression catheter for intestinal obstruction | |
| SU1102610A1 (en) | Catheter |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200710 |
|
| RJ01 | Rejection of invention patent application after publication |