CN115607844A

CN115607844A - Gastric cavity phototherapy sterilization device and method based on blue light LED

Info

Publication number: CN115607844A
Application number: CN202211272456.4A
Authority: CN
Inventors: 孙洁; 史肖华; 刘杰
Original assignee: Suzhou Science and Technology Town Hospital
Current assignee: Suzhou Science and Technology Town Hospital
Priority date: 2020-03-26
Filing date: 2020-03-26
Publication date: 2023-01-17
Also published as: CN111388873A

Abstract

The invention discloses a phototherapy sterilization device for a gastric cavity based on a blue light LED, wherein the device comprises: a hose; the at least one air bag surrounds the outer side of the hose and is connected with the hose in a sealing mode, and an inflation port corresponding to each air bag is arranged on the wall of the hose; the at least one air bag conduit is arranged in the hose and extends along the hose, one end of each air bag conduit is only communicated with the corresponding inflating opening of one air bag, and the other end of each air bag conduit is connected with the inflating device; the light source catheter is arranged in the hose, extends to the tail end of the hose along the hose and is communicated with the gastric cavity, and the blue light LED is arranged in the light source catheter through a guide wire and is positioned in the space of the at least one air bag. The invention has the advantages that the device is used for treatment, the undesirable sterilization effect of the existing stomach fundus and the part of the stomach body which is bent greatly and is close to the stomach fundus is obviously improved, and no side effect is brought to the human body.

Description

Gastric cavity phototherapy sterilization device and method based on blue light LED

Technical Field

The invention relates to the field of medical instruments, in particular to a gastric cavity phototherapy sterilization device and method based on a blue light LED.

Background

Helicobacter pylori (Hp) is a gram-negative microaerophilic bacterium, colonizes the gastric and duodenal mucosa of humans, and is the only bacterium found in humans that survives in the stomach. China is a high incidence area of Hp infection, and the incidence rate tends to rise year by year. Survey data shows that the detection rate of Hp in adults in China reaches 30% -80%, and people infected with Hp have obvious regional, economic, life habit and occupational differences. The infection of Hp is the cause of peptic ulcer, gastric cancer and other diseases, and in the 90 s of the 20 th century, the international agency for research on cancer defines Hp as a class I carcinogenic factor of gastric cancer. Hp is mainly transmitted through human-to-human 'fecal-oral', 'oral-oral' and 'gastric-oral' routes, and research shows that the existence of Hp can be detected in saliva, vomitus regurgitation and dental plaque.

The form of Hp is spiral or arc bending, one end of the thallus has 2-6 flagella, the thallus penetrates the mucus layer through the movement of the flagella after entering the stomach, and is fixedly planted in the stomach fovea and the epithelium fold position through the secretory adhesin, and the thallus can not be discharged out of the body along with the excrement. In addition, the secreted urease can hydrolyze urea to produce ammonia, neutralize gastric acid and form a protective shell around Hp, so that the urea can survive in the strong acid environment in the stomach. Hp is a intractable pathogenic bacterium, and patients cannot spontaneously clear after infection, and the current main treatment mode depends on various antibiotics, such as clarithromycin, metronidazole and the like serving as antibacterial agents. However, in recent years, the rate of eradication of Hp has been gradually reduced due to the increasing rate of antibiotic resistance, and for example, a drug-resistant strain of clarithromycin has a success rate of only 30% in the radical treatment of Hp. Meanwhile, hp treatment with antibiotics leads to some side effects inevitably as well as increase in the drug resistance rate of antibacterial drugs.

With the development of medical technology and the popularization of endoscopic treatment, physical therapy becomes a new means for treating digestive tract diseases, and researches show that ultraviolet light can kill helicobacter pylori cultured in vitro, has good bactericidal effect on clarithromycin-resistant helicobacter pylori, and has toxic and side effects on normal cells. In recent years, blue light is widely applied clinically by virtue of high bundling property, controllable energy, high safety and the like, and the blue light photodynamic sterilization method provides a possibility for eradicating Hp by replacing the traditional medicines. The blue light is visible light with the wavelength of 375-480nm, and after the visible light irradiates a bacterial group, the active oxygen is generated, the endogenous porphyrin of the bacteria is excited, the endogenous porphyrin receiving photons reacts with oxygen molecules to generate energy transfer, and active oxides such as singlet oxidation hydroxyl free radicals and the like with cytotoxicity are generated, so that proteins, lipids, nucleic acids and the like are damaged to generate a bactericidal effect. Unlike ultraviolet photodynamic sterilizing method, blue light sterilizing method has no obvious toxic side effect on normal tissue cell.

The current method for killing helicobacter pylori in the gastric cavity by using blue light mainly comprises the following two modes: 1. the blue light source is guided by an endoscope to be placed in the gastric cavity, and the gastric cavity is irradiated by adjusting the output power of the blue light source. The research result shows that the clearance rate of helicobacter pylori in the antrum of the stomach is the highest and reaches 97%, and the clearance rate of the fundus is 95%, and is only 86%. It was also found that the elimination rate of H.pylori did not increase independently of the increase of the blue-light irradiation dose, and that the elimination rate of different parts of the stomach was consistent with the stomach anatomy, with the fundus and the side folds where the greater curvature of the stomach was near the fundus being the most, followed by the lesser curvature of the stomach, and the antrum being smoother and without folds. The mode has obvious treatment effect on the polished antrum, but has not ideal treatment effect on the fundus and the part of the stomach body, which is greatly bent and close to the fundus. 2. A miniaturized blue light LED capsule is designed, swallowed into a gastric cavity, and achieves a treatment effect through blue light emitted by the capsule. However, the capsule with smaller volume has a limited action range, and the capsule entering the stomach cavity in the fasting state easily and rapidly passes through the stomach cavity to enter the small intestine along with the peristalsis of the stomach cavity, so that the treatment effect is not obvious.

Therefore, there is a need to provide a new device and method for killing helicobacter pylori in the stomach cavity by using blue light to solve the above problems.

Disclosure of Invention

In order to solve the defects of the prior art, the invention aims to provide a novel phototherapy sterilization device and a novel phototherapy sterilization method for a gastric cavity based on a blue light LED.

In order to achieve the above purpose, the embodiment of the present invention provides the following specific technical solutions:

in a first aspect, a blue-light LED-based gastric cavity phototherapy sterilization device is provided, which comprises:

a hose;

the at least one air bag surrounds the outer side of the hose and is connected with the hose in a sealing mode, and an inflation port corresponding to each air bag is arranged on the wall of the hose;

the at least one air bag conduit is arranged in the hose and extends along the hose, one end of each air bag conduit is only communicated with the corresponding inflation port of one air bag, and the other end of each air bag conduit is connected with an inflation device;

the light source catheter is arranged in the hose, extends to the tail end of the hose along the hose and is communicated with the gastric cavity, and the blue light LED is arranged in the light source catheter through a guide wire and is positioned in the space of the at least one air bag.

Furthermore, one end of the light source catheter communicated with the outside is connected with a gastric juice detection device.

Further, the gastric juice detecting device is an air-filling/liquid-pumping device, such as a medical syringe.

Further, the at least one bladder is disposed proximate the hose end.

Further, the placement of the blue LED within the light source conduit via a guidewire comprises: and fixing the blue light LED on the guide wire, and placing the blue light LED into the light source catheter along with the guide wire.

Further, at least one gasbag is two gasbags, two gasbags set up in proper order at the interval in being close to the position of hose end, at least one gasbag pipe is two gasbag pipes, and every gasbag pipe communicates with the corresponding inflation inlet of a gasbag respectively.

Further, the placement of the blue LED within the light source conduit via a guidewire comprises: and fixing the two blue light LEDs on the guide wire at intervals, wherein the interval distance is consistent with that of the two air bags, and the two blue light LEDs are arranged in the light source catheter under the guidance of the guide wire.

Furthermore, the distance between the inflation inlet closest to the tail end of the hose and the tail end of the hose is 4-6 cm, and the distance between two adjacent inflation inlets is 10-12 cm.

Further, the material of the hose, the balloon catheter and the light source catheter is a high-light-transmittance material and/or an acid-resistant and corrosion-resistant material, and is preferably polyurethane.

In a second aspect, there is provided an improved blue LED-based gastric cavity phototherapy sterilization device, the device comprising:

at least one balloon catheter;

the light source catheter and the at least one air bag catheter are integrally cast to form a parallel tube bundle structure;

at least one air bag surrounding the outside of the tube bundle structure and connected with the tube bundle structure in a sealing manner;

each of the at least one balloon catheter having one end connected to only one of the at least one balloon and another end connected to an inflation device;

the tail end of the light source catheter is communicated with the gastric cavity, and the blue light LED is arranged in the light source catheter through a guide wire and is positioned in the space of the at least one air bag.

Further, the at least one balloon is disposed proximate the light source catheter tip.

Further, the at least one air bag is two air bags, the two air bags are sequentially arranged at the position close to the tail end of the light source catheter at intervals, the at least one air bag catheter is two air bag catheters, and the two air bag catheters are respectively communicated with the two air bags.

Furthermore, the outlet end of the balloon catheter closest to the tail end of the light source catheter is 4-6 cm away from the tail end of the light source catheter, and the distance between the outlet ends of two adjacent balloon catheters is 10-12 cm.

Further, the material of the balloon, the balloon catheter and the light source catheter is a high-light-transmittance material and/or an acid-resistant and corrosion-resistant material, and is preferably polyurethane.

In a third aspect, a therapeutic method using the phototherapy sterilization device for gastric cavity is provided, the method comprises the following steps:

under the guidance of a guide wire in the light source catheter, after the phototherapy sterilization device for the gastric cavity is placed in the gastric cavity, the position of the phototherapy sterilization device for the gastric cavity is detected through a gastric juice detection device which is connected with one end, communicated with the outside, of the light source catheter;

when the detection result is that the light source catheter is communicated with gastric juice, the inflating device inflates the balloon through the balloon catheter;

when the inflation amount reaches the set value of the sufficient exposure of the stomach wall, the inflation is stopped, and the blue light LED in the air bag space performs phototherapy sterilization.

Further, the detection result is that the light source catheter comprises, before communicating with gastric juice: all of the balloons are determined to be located within the gastric cavity.

Further, said determining that all of said balloons are located within the gastric cavity comprises: through the surface mark size scale at stomach chamber phototherapy sterilizing equipment, work as the terminal internal size that gets into of stomach chamber phototherapy sterilizing equipment is more than 65cm, confirms all promptly the gasbag is located the stomach intracavity.

Further, the total length of the phototherapy sterilization device for the gastric cavity is about 120cm, 4 size scales are marked on the outer surface of the phototherapy sterilization device for the gastric cavity, and the first scale is 45cm, which indicates that the tail end of the phototherapy sterilization device for the gastric cavity reaches the cardia; the second scale is 55cm, and indicates that the tail end of the phototherapy sterilization device for the stomach cavity enters the stomach body; the third scale is 65cm, which indicates that the tail end of the phototherapy sterilization device for the gastric cavity enters the pylorus; the fourth scale is 75cm, which indicates that the tail end of the phototherapy sterilization device for the gastric cavity enters the duodenum.

Further, the inflation device is an inflator or a manual pumping device.

Further, the set value range of the aeration quantity is 1000 mL-1500 mL.

Further, the blue light emitted by the blue light LED has a wavelength of 375-480nm, preferably 375-425 nm, and most preferably 405-410 nm.

The technical scheme provided by the embodiment of the invention has the following beneficial effects:

1. the phototherapy sterilization device for the stomach cavity based on the blue light LED has the advantages of simple structure, easiness in operation, high repeated utilization rate and good sterilization effect, obviously improves the sterilization effect of the stomach fundus and the large bent part of the stomach body close to the stomach fundus by using the blue light source in the prior art, and can ensure better sterilization effect by controlling the irradiation dose of the blue light;

2. the method for phototherapy sterilization of the gastric cavity based on the blue light LED is simple and safe to operate and convenient to control, and avoids the increase of the drug resistance rate of antibacterial drugs and side effects on human bodies caused by treatment with antibiotic drugs and the toxic and side effects on normal cells caused by ultraviolet sterilization treatment.

Drawings

In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required to be used in the description of the embodiments are briefly introduced below, the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a block diagram illustrating a blue LED based gastric cavity phototherapy sterilization device according to an exemplary embodiment;

FIG. 2 is a block diagram of a blue LED based gastric cavity phototherapy sterilization device according to another exemplary embodiment;

FIG. 3 is a block diagram of an improved blue LED-based gastric cavity phototherapy sterilization device shown in accordance with an exemplary embodiment;

FIG. 4 is a schematic diagram illustrating the operation of a blue LED based gastric cavity phototherapy sterilization device according to an exemplary embodiment;

fig. 5 is a flow diagram illustrating a method of blue LED based phototherapy sterilization of a gastric cavity, according to an exemplary embodiment.

Wherein: 1-blue light LED;1 a-a first blue LED;1 b-a second blue LED; 2-air bag; 2 a-a first balloon; 2 b-a second balloon; 3-a hose; 4-balloon catheters; 4 a-a first balloon catheter; 4 b-a second balloon catheter; 5-a light source conduit; 6-gastric juice detection device; 7-an inflator.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The phototherapy sterilization device and method for the gastric cavity based on the blue light LED provided by the embodiment of the invention have the advantages that the sterilization effect on the fundus stomach and the part of the large bent part of the stomach body close to the fundus stomach in the prior art, which are not ideal, is obviously improved, and no side effect is brought to the human body.

Fig. 1 is a structural diagram of a phototherapy sterilization device for a stomach cavity based on blue light LEDs according to an exemplary embodiment, and referring to fig. 1, as a preferred embodiment, in an embodiment of the present invention, the phototherapy sterilization device for a stomach cavity based on blue light LEDs includes: a hose 3; the air bag 2 surrounds the outer side of the hose 3 and is connected with the hose in a sealing mode, the sealing mode can be realized by adopting sealing adhesive tapes, sealing glue or an injection molding mode, and the like, an inflation inlet corresponding to the air bag 2 is formed in the wall of the hose 3, the air bag 2 is close to the tail end of the hose 3, and the measurement distance from the inflation inlet to the tail end of the hose is about 4-6 cm; the air bag guide pipe 4 is arranged in the hose 3 and extends along the hose, one end of the air bag guide pipe 4 is communicated with the inflating opening, the communication mode can be realized in a mode that the air bag guide pipe passes through the inflating opening and extends out of the hose 3, furthermore, in order to ensure the inflating effect, the connecting part of the inflating opening and the air bag guide pipe can be sealed, and the other end of the air bag guide pipe 4 is connected with the inflating device 7; the light source catheter 5 is arranged in the hose 3, extends to the tail end of the hose along the hose and is communicated with the stomach cavity, the blue light LED is fixed on the guide wire, the fixing mode can be realized by adopting welding, winding or binding and the like, and is arranged in the light source catheter 5 along with the guide wire until the blue light LED is positioned in the space of the air bag 2. The end of the light source catheter 5 communicating with the outside is connected with a gastric juice detecting device 6, and the gastric juice detecting device 6 can be an inflation/liquid pumping device, such as: a medical injector. The materials of the hose, the balloon catheter and the light source catheter are high-light-transmittance materials and/or acid-resistant and corrosion-resistant materials, and polyurethane is preferred.

Fig. 2 is a structural diagram of a phototherapy sterilization device for a stomach cavity based on blue light LEDs according to another exemplary embodiment, and referring to fig. 2, as a preferred embodiment, in an embodiment of the present invention, the phototherapy sterilization device for a stomach cavity based on blue light LEDs includes: a hose 3; the first air bag 2a and the second air bag 2b are surrounded on the outer side of the hose 3 and are in sealed connection with the hose, the sealing mode can be realized by adopting sealing adhesive tapes, sealing glue or injection molding and the like, inflation ports corresponding to the first air bag 2a and the second air bag 2b are arranged on the pipe wall of the hose 3, the first air bag 2a and the second air bag 2b are close to the tail end of the hose 3, the inflation port corresponding to the second air bag 2b is 4-6 cm away from the tail end of the hose, and the distance between the two inflation ports corresponding to the first air bag 2a and the second air bag 2b is 10-12 cm; the first air bag conduit 4a and the second air bag conduit 4b are arranged in the hose 3 and extend along the hose, the first air bag conduit 4a is communicated with an inflation port corresponding to the first air bag 2a, the second air bag conduit 4b is communicated with an inflation port corresponding to the second air bag 2b, the communication mode can be realized in a mode that the first air bag conduit 4a penetrates through the inflation port and extends to the outer side of the hose 3, furthermore, in order to ensure the inflation effect, the connection position of the inflation port and the air bag conduit can be sealed, and the other ends of the first air bag conduit 4a and the second air bag conduit 4b are both connected with the inflation device 7; the light source catheter 5 is arranged in the hose 3, extends to the tail end of the hose along the hose and is communicated with the gastric cavity, the first blue light LED1a and the second blue light LED1b are fixed on the guide wire at intervals, the fixing mode can be realized by adopting modes such as welding, winding or binding, the interval distance is consistent with the interval distance between the first air bag 2a and the second air bag 2b, and the light source catheter 5 is placed together with the guide wire until the first blue light LED1a and the second blue light LED1b are respectively positioned in the space of the first air bag 2a and the space of the second air bag 2 b. The end of the light source catheter 5 communicating with the outside is connected with a gastric juice detecting device 6, and the gastric juice detecting device 6 can be an inflation/liquid pumping device, such as: a medical injector. The materials of the hose, the balloon catheter and the light source catheter are high-light-transmittance materials and/or acid-resistant and corrosion-resistant materials, and polyurethane is preferred.

Fig. 3 is a structural diagram of an improved blue-light LED-based phototherapy sterilization device for the stomach, according to an exemplary embodiment, and referring to fig. 3, as a preferred embodiment, the phototherapy sterilization device for the stomach based on blue-light LED in the embodiment of the present invention comprises: a first balloon catheter 4a and a second balloon catheter 4b; the light source catheter 5, the light source catheter 5 and the first balloon catheter 4a and the second balloon catheter 4b are integrally cast to form a parallel tube bundle structure; the first air bag 2a and the second air bag 2b surround the outer side of the parallel tube bundle structure and are in sealing connection with the parallel tube bundle structure, the sealing mode can be realized by adopting sealing adhesive tapes, sealing glue or injection molding and the like, and the first air bag 2a and the second air bag 2b are sequentially arranged at the tail end close to the light source guide tube 5 at intervals; one end of the first air bag conduit 4a is connected with the first air bag 2a, the other end is connected with the inflating device 7, one end of the second air bag conduit 4b is connected with the second air bag 2b, and the other end is connected with the inflating device 7; the distance between the outlet end of the second balloon catheter 4b and the tail end of the light source catheter 5 is 4-6 cm, and the distance between the outlet ends of the first balloon catheter 4a and the second balloon catheter 4b is 10-12 cm; the tail end of the light source catheter 5 is communicated with the stomach cavity, the first blue light LED1a and the second blue light LED1b are fixed on the guide wire at intervals, the fixing mode can be realized by adopting modes such as welding, winding or binding, the interval distance is consistent with the interval distance between the first air bag 2a and the second air bag 2b, and the interval distance is arranged in the light source catheter 5 along with the guide wire until the first blue light LED1a and the second blue light LED1b are respectively positioned in the space of the first air bag 2a and the space of the second air bag 2 b. The end of the light source catheter 5 communicating with the outside is connected with a gastric juice detecting device 6, and the gastric juice detecting device 6 can be an inflation/liquid pumping device, such as: a medical injector. The material of the balloon, the balloon catheter and the light source catheter is a high-light-transmittance material and/or an acid-resistant and corrosion-resistant material, and is preferably polyurethane.

Fig. 4 is a schematic diagram of an operating state of the phototherapy gastric cavity sterilization device based on blue light LEDs according to an exemplary embodiment, and referring to fig. 4, the phototherapy gastric cavity sterilization device based on blue light LEDs adopts two airbags and two blue light LEDs, and by inflating the two airbags respectively, the corresponding stomach and the bottom of the stomach are inflated, so that the stomach wall in the gastric cavity is fully exposed, and the corresponding two blue light LEDs in the two airbag spaces emit blue light, thereby achieving the optimal effect of phototherapy sterilization in the stomach.

Fig. 5 is a flowchart illustrating a method of phototherapy sterilization of a gastric cavity based on blue LEDs according to an exemplary embodiment, and referring to fig. 5, the method of phototherapy sterilization of a gastric cavity based on blue LEDs includes: under the guide of a guide wire in the light source catheter, after the phototherapy sterilization device for the gastric cavity is placed in the gastric cavity, the position of the phototherapy sterilization device for the gastric cavity is detected by a gastric juice detection device which is connected with one end of the light source catheter communicated with the outside; when the detection result is that the light source catheter is communicated with gastric juice, the air charging device charges the air bag through the air bag catheter; when the inflation amount reaches the set value of the sufficient exposure of the stomach wall, the inflation is stopped, and the blue light LED in the air bag space performs phototherapy sterilization.

In particular, the gastric juice detecting device is an inflation/aspiration device, such as a medical syringe.

Specifically, the detection result is that the light source catheter comprises the following components before being communicated with gastric juice: all balloons were determined to be located within the stomach cavity.

Specifically, determining that all balloons are located within the gastric cavity includes: through marking the size scale on the outer surface of the phototherapy sterilizing device for the gastric cavity, when the tail end of the phototherapy sterilizing device for the gastric cavity enters the body, the size is more than 65cm, and all air bags are determined to be located in the gastric cavity.

Specifically, the total length of the phototherapy sterilization device for the gastric cavity is about 120cm, 4 size scales are marked on the outer surface of the phototherapy sterilization device for the gastric cavity, the first scale is 45cm, and the fact that the tail end of the phototherapy sterilization device for the gastric cavity reaches the cardia is shown; the second scale is 55cm, which indicates that the tail end of the phototherapy sterilization device of the gastric cavity enters the stomach body; the third scale is 65cm, which indicates that the tail end of the phototherapy sterilization device of the gastric cavity enters the pylorus; the fourth scale is 75cm, which indicates that the tail end of the phototherapy sterilization device of the gastric cavity enters the duodenum.

Specifically, the inflation device is an inflator or a manual pumping device.

Specifically, the set value range of the aeration quantity is 1000 mL-1500 mL.

Specifically, the blue light emitted from the blue LED has a wavelength of 375 to 480nm, preferably 375 to 425nm, and most preferably 405 to 410nm.

Animal experiments:

selecting 405nm blue light as an irradiation light source, and irradiating helicobacter pylori suspension (2 x10 ul) cultured in vitro for 20s, 40s, 80s, 160s and 320s respectively, wherein the corresponding irradiation energy is 4J/cm2, 16J/cm2 and 32J/cm2 respectively. The results suggest that blue light with a wavelength of 405nm has a bactericidal effect on helicobacter pylori strains, and the bactericidal effect is the best when the blue light is irradiated for 320s at 32J/cm2, and then the blue light with a wavelength of 405nm is selected for the next animal experiment.

Selecting 60 successfully molded rats infected by helicobacter pylori, randomly dividing the rats into 2 groups, and respectively irradiating the gastric cavity by using a blue light source with an air sac and a common blue light source, wherein the blue light is 405nm, the irradiation energy is 40J/cm & lt 2 & gt, and the irradiation time is 10min. After irradiation, the gastric antrum, the stomach body and the gastric fundus mucosa are respectively selected for rapid urease test, and negative results show that helicobacter pylori is successfully eliminated, otherwise, the negative results fail.

The experimental results are shown in the table below, and the clearance of the blue light source with a balloon in the parts with rich folds of the stomach body and the fundus is obviously higher than that of the common blue light source, while the clearance of the blue light source in the smooth parts of the antrum of the stomach is not obviously different.

The technical features of the above embodiments can be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the above embodiments are not described, however, as long as there is no contradiction between the combinations of the technical features, the scope of the present description should be considered as being described in the present specification.

The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.

Claims

1. A gastric cavity phototherapy sterilizing device based on blue light LED, its characterized in that, the device includes:

a hose;

2. The phototherapy sterilization device for gastric cavity based on blue light LED as claimed in claim 1, wherein a gastric juice detection device is connected to the end of the light source catheter communicating with the outside.

3. The blue LED-based phototherapy sterilization device for the stomach cavity of claim 1, wherein the at least one balloon is disposed near the end of the tube.

4. The blue-LED based gastric cavity phototherapy sterilization device according to one of the claims 1 to 3, wherein the blue-LED being placed inside the light source conduit by a guide wire comprises: and fixing the blue light LED on the guide wire, and placing the blue light LED into the light source catheter along with the guide wire.

5. The phototherapy sterilization device for gastric cavity based on blue light LED as claimed in one of claims 1 to 3, wherein the at least one balloon is two balloons, the two balloons are sequentially and alternately arranged at a position close to the end of the hose, the at least one balloon catheter is two balloon catheters, and each balloon catheter is respectively communicated with an inflation port corresponding to one balloon.

6. The blue LED-based phototherapy sterilization device for the stomach cavity of claim 5, wherein the placement of the blue LED within the light source catheter over a guide wire comprises: and fixing the two blue light LEDs on the guide wire at intervals, wherein the interval distance is consistent with that of the two air bags, and the two blue light LEDs are arranged in the light source catheter under the guidance of the guide wire.

7. The phototherapy blue-light LED-based sterilization device for the stomach cavity is characterized in that the nearest inflation port is 4-6 cm away from the end of the hose, and the distance between two adjacent inflation ports is 10-12 cm.

8. The blue-light LED based phototherapy sterilization device for the stomach cavity as claimed in claim 1, wherein the material of the flexible tube, the balloon catheter and the light source catheter is a high light transmittance material and/or an acid and corrosion resistant material, preferably polyurethane.

9. A gastric cavity phototherapy sterilizing device based on blue light LED, its characterized in that, the device includes:

at least one balloon catheter;

one end of each balloon catheter in the at least one balloon catheter is connected with only one balloon in the at least one balloon, and the other end of each balloon catheter is connected with an inflating device;

10. A method of treatment using a blue LED based gastric cavity phototherapy sterilization device as defined in one of claims 1 to 9, the method comprising the steps of: