CN108066894B - PDT mask plate and PDT mirror body - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/04—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor combined with photographic or television appliances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/06—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements
- A61B1/07—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor with illuminating arrangements using light-conductive means, e.g. optical fibres
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/062—Photodynamic therapy, i.e. excitation of an agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0632—Constructional aspects of the apparatus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/065—Light sources therefor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0664—Details
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Abstract
The invention relates to a PDT mask plate and a PDT lens body, in particular to a PDT mask plate, wherein the PDT mask plate is provided with a first color block; the first color block is plated with a narrow-band light film system, and the optical indexes are as follows: the transmittance of the wave band of 400nm-600nm is cut off and the cut-off depth is more than OD4, the transmittance of the wave band of 617nm-647nm is 0.1< t <1%, and the transmittance of the wave band of 660nm-1100nm is cut off and the cut-off depth is more than OD4. The PDT mask plate is provided with the first color block plated with the narrow-band light film system, the first color block has special optical indexes for PDT treatment wave bands, the transmittance of the first color block for treatment light and illumination light is lower, overexposure of an image of a shot object is avoided on the premise that the irradiation intensity of PDT treatment light is not reduced, the irradiation time of PDT treatment light is prevented from being prolonged, and the real-time visualization of the PDT treatment process is ensured.
Description
Technical Field
The invention relates to a PDT mask plate and a PDT mirror body.
Background
Photodynamic therapy (Photodynamic Therapy, PDT) has proven to be an effective means of treating malignant tumors and precancerous lesions. The clinical procedure of PDT involves the following two main steps: (1) Intravenous injection of photosensitizer into patient, after metabolism in human body for several or several tens of hours, concentrating in focus tissue; (2) According to the spectral absorption characteristics of the photosensitizer, specific wave bands and corresponding doses of therapeutic light are irradiated to focus tissues. The principle of PDT for treating tumors is as follows: after photon absorption, the photosensitizer molecules enriched in focus tissue change the energy state from steady state to high energy state, and transfer energy to oxygen molecules (tri-state oxygen 3O) in biological tissue 2 ) Is activated to form singlet oxygen (1O) 2 ) And superoxide anion radical (O) 2 - ) The latter two have strong destructive action on various biological macromolecules in tumor cells, so that the tumor is necrotized and apoptotic, the capillary endothelium of tumor tissue is damaged and forms microthrombus, and finally the purpose of destroying tumor tissue is reached.
Treatment light for treating tumors by PDT can be introduced into a body cavity through an optical fiber to irradiate tumor tissue in the cavity, for example, WO2002007629A1. In addition, the PDT can be combined with an endoscope to monitor the treatment process of the tumor in the cavity in real time, when the PDT is combined with the endoscope, the treatment light of the PDT can pass through a special light guide fiber for PDT treatment and extend into a body cavity to irradiate the tumor tissue through a surgical instrument channel of the endoscope, such as patent document JP2006130183A, JP2005080836A, JP2008125821A, CN101677755A, or is integrated with an endoscope cold light source, so that the common observation light and the treatment light of the PDT are conducted to the head end (position end) of the endoscope through a light guide fiber of the same bundle of endoscope to irradiate the cavity, such as patent document JP2011067269A, JP2011167229a.
In actual treatment, the treatment light irradiation time for implementing the PDT treatment is usually tens of minutes, so that the PDT treatment process is monitored by utilizing an endoscope in real time in a visual manner, medical staff can be helped to evaluate the treatment effect in time by observing the change of the focus tissue morphology, the treatment light dosage is further quantitatively controlled, and the clinical treatment risks such as mucosa tissue perforation, massive hemorrhage and the like are effectively reduced. However, the therapeutic light power of the PDT can reach 1-2W, and the light power density can reach 0.1W/cm2-1W/cm2 when the focal region is irradiated in a short distance, so when the PDT is matched with an endoscope to implement the intracavity tumor therapy, the intensity of therapeutic light reflected by the object and received by the image sensor often exceeds the linear response range of the image sensor, which leads to image overexposure and further leads to the adverse effect that the endoscope cannot be used for monitoring the PDT treatment process in real time.
On the other hand, in the course of performing PDT treatment, it is also necessary to be able to identify the spot area of the treatment light to help medical staff determine that the treatment light irradiation area is accurately covering the lesion tissue. Therefore, the intensity of the therapeutic light received by the image sensor and reflected by the subject cannot be so low that the human eye cannot accurately recognize the therapeutic spot irradiation region, possibly resulting in a decrease in the PDT treatment effect due to the spot irradiation region not covering the lesion region accurately.
The prior art respectively proposes the following technical schemes to achieve the purpose of monitoring the PDT treatment process in real time by using an endoscope. Furthermore, some technical solutions not only can monitor the PDT treatment process in real time, but also can identify the PDT treatment light irradiation area during the PDT treatment process.
Patent document CN101677755a proposes an image generating apparatus in which an optical cut filter is provided between an object and an imaging unit, and light in a second wavelength band (for illumination) that is a part of a first wavelength band reflected on the object is cut off; and the device also comprises a compensation processing part for correspondingly compensating the brightness and color loss of the image caused by the light cut-off filter at the second wavelength band.
In JP2011067269a, an endoscope apparatus is proposed that includes an optical filter between an object and an imaging unit, and attenuates light in a therapeutic light band entering the imaging unit, thereby ensuring that the color of an image is hardly affected by PDT therapeutic light during normal light observation, PDT treatment, and photodynamic fluorodiagnosis.
In patent document JP2008125821a, an endoscope apparatus is proposed that quantitatively controls PDT treatment light reflected by a subject received by an image sensor during an electronic shutter on time by controlling the electronic shutter time and the PDT treatment light on and off time every frame image period, thereby ensuring that overexposure of a reflected light image reflected by the subject due to an excessively high intensity of PDT treatment light does not occur.
In patent document JP2012065945a, an endoscope apparatus is proposed which turns off PDT treatment light during an electronic shutter on period and a PDT treatment light off period by controlling the electronic shutter on period and the PDT treatment light off period, and turns on guide light (wavelength and spot irradiation area are the same as those of treatment light but power is only in the order of milliwatts for indicating treatment spot position) during the period, thereby ensuring that the condition of overexposure of reflected light image reflected by a subject due to excessively high PDT treatment light intensity does not occur during PDT treatment, and at the same time, enables observation of guide light irradiation spots in reflected light image reflected by the subject, thereby helping medical staff to judge in time whether the position of treatment light irradiation spot covers a lesion area, and to judge whether or not to adjust the irradiation area of treatment light accordingly.
Patent document CN101677755a proposes a method of providing an optical cut filter between an object and an endoscopic imaging section and cutting off light in a second wavelength band, which is a part of a first wavelength band, but has the following problems:
(1) The claims of this patent mention that the light cut filter cuts off light of the second wavelength band, that is, the intensity of light of the second wavelength band entering the image sensor of the image pickup section among reflected light reflected by the subject is approximately 0. When light of the second wavelength band is used as the PDT treatment light source, there is a problem that the treatment spot irradiation area cannot be observed by the reflected light image reflected by the subject, and there is a possibility that the PDT treatment is difficult to achieve the desired effect due to incomplete coverage of the lesion area by the PDT treatment spot.
Patent document JP2011067269a proposes a method of providing an optical filter between an object and an endoscopic imaging section to attenuate light in a therapeutic light band entering the imaging section, but the filter characteristics of the optical filter are not clear. Thereby causing the following problems: if the light quantity of the PDT treatment light in the reflected light reflected by the object is too high, the structural details of the object cannot be clearly observed in the reflected light image; or the light quantity of the PDT treatment light in the reflected light reflected by the subject is too low, which may cause that the irradiation spot of the PDT treatment light cannot be clearly observed in the reflected light image, and thus the treatment effect may be reduced due to that the spot of the PDT treatment light does not accurately cover the lesion area.
Both patent documents JP2008125821a and JP2012065945A are methods of reducing the influence of PDT treatment light on an image by a signal timing control, that is, controlling the amount of PDT treatment light reflected by an object received by an image sensor during an electronic shutter open time of one frame image period. The signal control method has the following defects:
(1) If the electronic shutter is opened for a long time, the irradiation time of the PDT treatment light is limited in one frame image period, so that the PDT treatment time is prolonged, and the operation risk is increased;
(2) If the electronic shutter is opened for a short time, insufficient image brightness and poor signal-to-noise ratio are caused.
In summary, current PDT treatments suffer from image overexposure or inability to visualize.
Disclosure of Invention
In order to overcome the defects of the prior art, the invention aims to provide a PDT mask plate and a PDT lens body.
The technical scheme of the invention is as follows:
a PDT mask provided with a first color block; the first color block is plated with a narrow-band light film system, and the optical indexes are as follows: the transmittance of the wave band of 400nm-600nm is cut off and the cut-off depth is more than OD4, the transmittance of the wave band of 617nm-647nm is 0.1< t <1%, and the transmittance of the wave band of 660nm-1100nm is cut off and the cut-off depth is more than OD4.
The further technical scheme is as follows: the PDT mask plate is also provided with a second color block, a third color block and a fourth color block which are plated with a narrow-band optical film system; the optical indexes of the second color block are as follows: the transmission cutoff of the wave band of 400nm-560nm is greater than OD2, the transmission of 590nm is greater than 45% and the full width half maximum is greater than 20nm, the transmission cutoff of the wave band of 611 nm-647nm is greater than OD4, the transmission of 670nm is greater than 45% and the full width half maximum is greater than 20nm, and the transmission cutoff of the wave band of 700nm-1100nm is greater than OD2; the optical indexes of the third color block are as follows: the transmission and the cutoff of the wave band of 400nm-480nm are cut off, the transmission rate of 535nm is more than 65 percent, the full width at half maximum is less than 60nm, the transmission and the cutoff of the wave band of 611 nm-647nm are more than OD4, the transmission and the cutoff of the wave band of 650nm-1100nm are more than OD2; the optical index of the fourth color block is that the 450nm transmittance is more than 50 percent, the full width at half maximum is less than 60nm, the transmission of the 500nm-610nm wave band is cut off, the cut-off depth is more than OD2, the transmission of the 617nm-647nm wave band is cut off, the cut-off depth is more than OD4, and the transmission of the 650nm-1100nm wave band is cut off, and the cut-off depth is more than OD2.
The further technical scheme is as follows: the first color block, the second color block, the third color block and the fourth color block are arranged in a 2X2 matrix.
A PDT mirror body comprises a body and an image sensor module arranged on the body; the image sensor module is provided with the PDT mask plate
The further technical scheme is as follows: the PDT mirror body also comprises a first optical fiber used for guiding therapeutic light and a second optical fiber used for guiding illumination light; the body is provided with a clamp hole for installing the optical fiber and an illumination light guide hole for installing the second optical fiber.
The further technical scheme is as follows: the number of the second optical fibers and the illumination light guide holes is two.
The further technical scheme is as follows: the body is also provided with a water vapor nozzle positioned at the end part.
The further technical scheme is as follows: the therapeutic light is 632nm + -15 nm laser or narrow band LED light.
Compared with the prior art, the invention has the technical effects that: a PDT mask plate is provided with a first color block of a plating narrow-band light film system, the first color block has special optical indexes on PDT treatment wave bands, the transmittance of the first color block to treatment light and illumination light is lower, overexposure of an image of a shot object is avoided on the premise that the irradiation intensity of PDT treatment light is not reduced, and the PDT treatment light irradiation time is prevented from being prolonged and the real-time visualization of the PDT treatment process is ensured.
Further, the PDT mask plate is provided with a second color block, a third color block and a fourth color block which are coated with a narrow-band light film system, so that the light intensity of PDT treatment light wave bands reflected by a shot object entering the image pickup part is reduced appropriately, on one hand, the image of the shot object is ensured not to be subjected to image overexposure due to overhigh PDT treatment light intensity, on the other hand, the spot irradiation area of PDT treatment light can be displayed in real time in the image of the shot object, and further medical staff can be helped to adjust the spot size and the position of the PDT treatment light in time, the lesion area of the shot object is accurately covered by the PDT treatment light, and the clinical effect of PDT treatment is ensured.
The invention is further described below with reference to the drawings and specific embodiments.
Drawings
FIG. 1 is a schematic illustration of a PDT mask;
FIG. 2 is a schematic view of a PDT mirror;
FIG. 3 is a block diagram of the circuitry of a PDT mirror;
FIG. 4 is a graph showing spectral characteristics of second, third and fourth color patches of a PDT mirror mask;
fig. 5 is a spectral diagram of a first color patch of a mask plate for a PDT lens.
Reference numerals
10 PDT mask plate 20 PDT mirror body
1. First color block 2 second color block
3. Third color block 4 fourth color block
5. Body 51 pincer hole
52. Water vapor nozzle of illumination light guide hole 53
6. Image sensor module
Detailed Description
In order to more fully understand the technical content of the present invention, the following technical solutions of the present invention are further described and illustrated with reference to the schematic drawings, but are not limited thereto.
A PDT mask plate is provided with a first color block. The first color block is plated with a narrow-band light film system, and the optical indexes are as follows: the transmittance of the wave band of 400nm-600nm is cut off and the cut-off depth is more than OD4, the transmittance of the wave band of 617nm-647nm is 0.1< t <1%, and the transmittance of the wave band of 660nm-1100nm is cut off and the cut-off depth is more than OD4.
As shown in fig. 1, a PDT mask 10 is provided with a first color patch 1, a second color patch 2, a third color patch 3, and a fourth color patch 4.
The first color block 1 is coated with a narrow-band light film system, and the optical indexes are as follows: the transmittance of the wave band of 400nm-600nm is cut off and the cut-off depth is more than OD4, the transmittance of the wave band of 617nm-647nm is 0.1< t <1%, and the transmittance of the wave band of 660nm-1100nm is cut off and the cut-off depth is more than OD4.
The optical indexes of the second color lump 2 are as follows: the transmission cut-off of the wave band of 400nm-560nm is greater than OD2, the transmission rate of 590nm is greater than 45% and the full width half maximum is greater than 20nm, the transmission cut-off of the wave band of 611 nm-647nm is greater than OD4, the transmission rate of 670nm is greater than 45% and the full width half maximum is greater than 20nm, and the transmission cut-off of the wave band of 700nm-1100nm is greater than OD2.
The optical index of the third color block 3 is: the transmission and the cutoff depth of the wave band of 400nm-480nm are > OD2, the 535nm transmission is >65% and the full width at half maximum is <60nm, the transmission and the cutoff depth of the wave band of 611 nm-647nm are > OD4, and the transmission and the cutoff depth of the wave band of 650nm-1100nm are > OD2.
The optical index of the fourth color block 4 is that the 450nm transmittance is more than 50 percent, the full width at half maximum is less than 60nm, the transmission of the 500nm-610nm wave band is cut off, the cut-off depth is more than OD2, the transmission of the 617nm-647nm wave band is cut off, the cut-off depth is more than OD4, and the transmission of the 650nm-1100nm wave band is cut off, and the cut-off depth is more than OD2.
Preferably, the first color block 1, the second color block 2, the third color block 3 and the fourth color block 4 are arranged in a 2X2 matrix, specifically, the first color block 1, the second color block 2, the third color block 3 and the fourth color block 4 can be arranged in a 2X2 matrix at will, specifically, according to the actual situation, the PDT mask plate 10 is provided with a plurality of 2X2 matrices of the first color block 1, the second color block 2, the third color block 3 and the fourth color block 4.
As shown in fig. 2, a PDT mirror 20 includes a main body 5, an image sensor module 6 disposed on the main body 5, and the image sensor module 6 is provided with the PDT mask 10.
Specifically, the PDT mirror 20 further includes a first optical fiber for guiding therapeutic light, a second optical fiber for guiding illumination light, and the body 5 is provided with a pincer hole 51 for mounting the optical fiber, and an illumination light guiding hole 52 for mounting the second optical fiber.
Specifically, the number of the second optical fibers and the illumination light guide holes 52 is two.
Specifically, the body 5 is further provided with a water vapor spout 53 at the end.
In particular, the therapeutic light is a laser light of 632 nm.+ -.15 nm or a narrow band LED light.
As shown in FIG. 3, the circuitry of the PDT mirror employs a circuit configuration as shown.
As shown in fig. 4 and 5, the second color block 2, the third color block 3 and the fourth color block 4 of the mask are R color blocks, G color blocks and B color blocks, respectively, of the mask, the second color block 2, the third color block 3 and the fourth color block 4 are cut off at a therapeutic light band of 632nm±15nm, and the cut-off depth is larger than OD4. The first color block is PDT color block, which is transparent at 632nm + -15 nm of therapeutic light band, the transmittance t is between 0.1% -1%, the wavelength band is cut-off at 400nm-600nm, and the cut-off depth is larger than OD4.
The principle of the working process is as follows:
1. endoscopic clinical examination mode: under the condition of white light illumination or special light illumination, the transmittance of a first color block of the mask plate 4 is between 0.1% and 1%, is far lower than the transmittance of a second color block 2, a third color block 3 and a fourth color block 4 of the mask plate, and the white light image is synthesized by the response output signals of pixels under the first color block, the second color block 2, the third color block 3 and the fourth color block 4 of the mask plate through the image color acquisition and the image brightness acquisition under the white light illumination mode or the special light illumination mode, so that the lesion position is observed. The mask plate first color block, the second color block 2, the third color block 3 and the fourth color block 4 respectively correspond to R4, R1 and G, B components of color information, and normal white light image information can be obtained by reasonably configuring the proportions of the R4, R1 and G, B color components.
2. In the PDT treatment stage, after treatment light is started, the treatment light intensity is hundreds times and thousands times of the mirror body illumination light intensity, but the cut-off depth of the mask plate second color block 2, the third color block 3 and the fourth color block 4 for the treatment light wave band to the transmission cut-off is larger than OD4, the treatment light can not influence the response of pixels under the mask plate second color block 2, the third color block 3 and the fourth color block 4 to the illumination light, and signals of the pixel responses under the mask plate second color block 2, the third color block 3 and the fourth color block 4 come from the mirror body illumination light. The first color block of the mask plate has certain transmittance for therapeutic light, the transmittance t is between 0.1 and 1 percent, after the therapeutic light is started, pixels under the first color block of the mask plate can output voltage signal information, the voltage signal information displays the irradiation area information of the therapeutic light, and the visualization of the treatment effect and the visualization of the irradiation position of the therapeutic light in the PDT treatment process are realized.
The foregoing examples are provided to further illustrate the present invention and are not intended to limit the scope of the invention, which is defined by the appended claims.
Claims (8)
1. The PDT mask plate is characterized by being provided with a first color block, a second color block, a third color block and a fourth color block which are coated with a narrow-band optical film system; the optical indexes of the first color block are as follows:
the transmission cutoff of the 400nm-600nm wave band and the cutoff depth > OD4, the transmission rate of the 617nm-647nm wave band is 0.1% < t <1%, the transmission cutoff of the 660nm-1100nm wave band and the cutoff depth > OD4, the second color block is an R color block, the third color block is a G color block, the fourth color block is a B color block, the second color block, the third color block and the fourth color block are cutoff in the 617nm-647nm wave band, and the cutoff depth is larger than OD4.
2. The PDT mask of claim 1, wherein the second color patch has an optical index of: the transmission cut-off of the wave band of 400nm-560nm is more than OD2, the transmission rate of 590nm is more than 45% and the full width half maximum is more than 20nm, the transmission rate of 670nm is more than 45% and the full width half maximum is more than 20nm, and the transmission cut-off of the wave band of 700nm-1100nm is more than OD2; the optical indexes of the third color block are as follows: the transmission cutoff of the wave band of 400nm-480nm is more than OD2, the transmission rate of 535nm is more than 65%, the full width at half maximum is less than 60nm, and the transmission cutoff of the wave band of 650nm-1100nm is more than OD2; the optical index of the fourth color block is that the 450nm transmittance is more than 50 percent, the full width at half maximum is less than 60nm, the wave band transmission cut-off of 500nm-610nm is more than OD2,
the 650nm-1100nm band is cut off by transmission and the cut-off depth > OD2.
3. The PDT mask of claim 1 or 2, wherein the first color patch, the second color patch, the third color patch, and the fourth color patch are arranged in a 2X2 matrix.
4. A PDT mirror body is characterized by comprising a body and an image sensor module arranged on the body; the image sensor module is provided with a PDT mask as claimed in any one of claims 1-3.
5. The PDT mirror of claim 4, further comprising a first optical fiber for introducing therapeutic light, a second optical fiber for introducing illumination light; the body is provided with a clamp hole for installing the optical fiber and an illumination light guide hole for installing the second optical fiber.
6. The PDT mirror according to claim 5, wherein the number of second optical fibers and illumination light guide holes is two.
7. The PDT mirror according to claim 5, wherein the body is further provided with a water vapor jet at an end.
8. The PDT mirror of claim 5, wherein the therapeutic light is a 632 nm+ -15 nm laser or a narrow band LED light.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711443852.8A CN108066894B (en) | 2017-12-27 | 2017-12-27 | PDT mask plate and PDT mirror body |
| PCT/CN2018/111381 WO2019128417A1 (en) | 2017-12-27 | 2018-10-23 | Pdt mask plate and pdt endoscope body |
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| CN201711443852.8A CN108066894B (en) | 2017-12-27 | 2017-12-27 | PDT mask plate and PDT mirror body |
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| CN108066894A CN108066894A (en) | 2018-05-25 |
| CN108066894B true CN108066894B (en) | 2024-01-12 |
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| CN108066894B (en) * | 2017-12-27 | 2024-01-12 | 深圳开立生物医疗科技股份有限公司 | PDT mask plate and PDT mirror body |
| CN118141305A (en) * | 2024-02-28 | 2024-06-07 | 广东因赛德思医疗科技有限公司 | Dyeing endoscope capable of laser treatment and application thereof |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101677755A (en) * | 2007-06-20 | 2010-03-24 | 奥林巴斯医疗株式会社 | Image generation device |
| JP2011104333A (en) * | 2009-10-23 | 2011-06-02 | Fujifilm Corp | Endoscope apparatus and distal end hood used for endoscope used therefor |
| CN102274004A (en) * | 2011-05-17 | 2011-12-14 | 易定容 | Blood vessel finder |
| CN106725263A (en) * | 2016-12-15 | 2017-05-31 | 深圳开立生物医疗科技股份有限公司 | It is applied to the imaging method of endoscopic system |
| CN107137824A (en) * | 2017-04-06 | 2017-09-08 | 中国人民解放军总医院 | With the photodynamic therapy system for visualizing and showing hot spot boundary function |
| CN208448446U (en) * | 2017-12-27 | 2019-02-01 | 深圳开立生物医疗科技股份有限公司 | A kind of PDT mask plate and PDT mirror body |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102707575B (en) * | 2012-05-18 | 2015-02-25 | 北京京东方光电科技有限公司 | Mask plate and method for manufacturing array substrate |
| CN103941541B (en) * | 2014-04-11 | 2017-05-24 | 京东方科技集团股份有限公司 | Position identifying method and device of mask plate polluted area |
| CN107153323A (en) * | 2017-06-12 | 2017-09-12 | 东旭（昆山）显示材料有限公司 | Mask plate and preparation method thereof, color membrane substrates and preparation method thereof and bore hole 3D display device and application |
| CN108066894B (en) * | 2017-12-27 | 2024-01-12 | 深圳开立生物医疗科技股份有限公司 | PDT mask plate and PDT mirror body |
-
2017
- 2017-12-27 CN CN201711443852.8A patent/CN108066894B/en active Active
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2018
- 2018-10-23 WO PCT/CN2018/111381 patent/WO2019128417A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101677755A (en) * | 2007-06-20 | 2010-03-24 | 奥林巴斯医疗株式会社 | Image generation device |
| JP2011104333A (en) * | 2009-10-23 | 2011-06-02 | Fujifilm Corp | Endoscope apparatus and distal end hood used for endoscope used therefor |
| CN102274004A (en) * | 2011-05-17 | 2011-12-14 | 易定容 | Blood vessel finder |
| CN106725263A (en) * | 2016-12-15 | 2017-05-31 | 深圳开立生物医疗科技股份有限公司 | It is applied to the imaging method of endoscopic system |
| CN107137824A (en) * | 2017-04-06 | 2017-09-08 | 中国人民解放军总医院 | With the photodynamic therapy system for visualizing and showing hot spot boundary function |
| CN208448446U (en) * | 2017-12-27 | 2019-02-01 | 深圳开立生物医疗科技股份有限公司 | A kind of PDT mask plate and PDT mirror body |
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| WO2019128417A1 (en) | 2019-07-04 |
| CN108066894A (en) | 2018-05-25 |
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