JPS6330028B2 - - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to a medical capsule for treating an affected area within a body cavity by irradiating light of a specific wavelength.

When hematoporphyrin derivatives (HPD) are intravenously injected (2.5mg/Kg) as a cancer detection and treatment method, they are mostly metabolized by normal cells within about 48 hours, but remain unmetabolized by tumor cells. There is.

When this substance is exposed to ultraviolet light with a wavelength of 405 nm, it emits fluorescence.

There are known products that take advantage of the properties of HPD that, when irradiated with 630 nm light that has been incorporated into tumor cells, causes a photochemical change and activates the HPD, causing necrosis of the cell tissue.

In order to utilize these properties to endoscopically treat cancer within body cavities, 48 hours after intravenous HPD injection,
Under the direct vision of an endoscope, ultraviolet light with a wavelength of 405 nm is applied to find the location of the cancer based on the above properties. Next, a possible method would be to use the same endoscope to irradiate the same area with light with a wavelength of 630 nm to selectively necrotize only cancer cells due to its properties.

However, in this method, irradiation with light with a wavelength of 630 nm takes several tens of minutes or more to necrotize only the cancer cells, and it must be repeated for many days, causing pain to the patient. It was very large. Furthermore, since the light is constantly aimed at the affected area that is moving within the body cavity, it places a heavy burden on the surgeon.

The present invention has been made focusing on the above circumstances,
The objective is to provide a medical capsule that can be fixed in the body cavity and irradiate the affected area with specific light for a long period of time.

An embodiment of the present invention will be described below with reference to FIGS. 1 to 3.

1 in FIG. 1 is a capsule body of a medical capsule 2. As shown in FIG. The capsule main body 1 has caps 4, 4 having hemispherical outer surfaces removably attached to each end of a cylindrical portion 3, and the caps 4, 4 are attached to the cylindrical portion 3 by screwing.
Three batteries 5 are housed inside the capsule body 1, located at the center of the cylindrical portion 3 and inside each cap 4, 4, and these constitute a power source. It should be noted that each of the batteries 5 can be attached and detached by removing the caps 4, 4. Further, a recess 6 is formed in the center of one side of the cylindrical portion 3, and a light emitting element portion 7 is attached and fixed to the bottom of the recess 6. This light emitting element section 7 is made up of, for example, a plurality of LEDs 8, and its output end face 9
is located at the bottom of the recess 6 and exposed. That is, the output end surface 9 is arranged at a position recessed from the other outer surface of the capsule body 1. In addition, the above
The light emitted by the LED 8 has a characteristic of having a peak wavelength of 630 nm. And the second
As shown in the figure, the LEDs 8 are connected to a power source consisting of batteries 5 via resistors 10. resistance 10
is built into the light emitting element section 7.

Next, a method of using the medical capsule 1 will be explained.

First, HPD is intravenously injected into a body cavity, and 48 hours later, an endoscope 11 is introduced into the body cavity, and under direct vision of the endoscope 11, ultraviolet rays with a wavelength of 405 nm are applied to search for a lesion that emits fluorescence. When a lesion is found, a battery 5 is loaded into the medical capsule 2 and assembled so that the light emitting element part 7 emits light. Then, this medical capsule 2 is introduced into the body cavity. At this point, the patient's body position is changed so that the light from the light emitting element section 7 is irradiated onto the lesion, or the medical capsule 2 is moved using the endoscope 11 so as to hit the wall surface. Thereafter, the tube 13 is immediately introduced through the insertion channel 12 of the endoscope 11, and the tube 13 is
Point the tip toward the medical capsule 2. Then, adhesive 14 is injected through this tube 13 to adhere the medical capsule 2 to the wall surface. Note that the adhesive 14 used here is preferably a medical instant adhesive made of a cyanoacrylate monomer.

Therefore, the medical capsule 2 can be placed on the wall surface of the body cavity for a long period of time. And in the meantime,
By continuously irradiating the lesion with light with a wavelength of 630 nm, it is possible to selectively cause necrosis of only abnormal cells.
Note that in this embodiment, the emission end surface 9 of the light emitting element section 7
Since it is formed by being recessed from the outer surface of the capsule body 1, even if a plurality of large LEDs 8 are provided, it is possible to evenly and uniformly irradiate the lesioned area with light.
Furthermore, compared to providing a diffuser plate between them, there is less light loss and more even illumination can be achieved.

On the other hand, FIG. 4 shows another embodiment of the present invention, in which the light emitting end surface 9 of the light emitting element section 7 is disposed continuously on the outer peripheral surface of the cylindrical section 3 of the capsule body 1 without being recessed. It is something. In other words, the cylindrical part 3
Since the recess 6 is not provided in the capsule body 1, a large battery 15 can be installed inside the capsule body 1.
Therefore, the capacity of the battery 15 is improved, and it is possible to emit light for a long time or with strong light.

Further, in this embodiment, at least both end side surfaces of the capsule body 1, such as the outer surface of the cap 4, are roughened 16, 16, thereby increasing the bonding area and improving the bonding strength.
By improving the adhesive strength, the battery 15
It is possible to prevent the medical capsule 2 from peeling off from the body wall surface before the energy disappears, and thereby prevent the irradiation time of the light onto the body wall surface from becoming unclear.

As explained above, the present invention is a medical capsule that can be placed in a body cavity and has a battery and a light emitting element in the capsule body, and by placing this in a diseased area in the body cavity, the diseased area can be protected for a long period of time. It can be treated by irradiating it with special light. In other words,
Once the medical capsule is placed in place, there is no need to insert an endoscope, which reduces the time and number of endoscopic procedures compared to methods that use an endoscope for irradiation. Can be done. Therefore, the patient's pain can be greatly reduced.

In addition, unlike when irradiating using an endoscope, the operator does not have to constantly aim and irradiate a moving lesion, which greatly reduces the burden on the operator. Furthermore, accurate irradiation can be continued.

[Brief explanation of the drawing]

FIG. 1 is a cross-sectional view showing one embodiment of the present invention, and FIG.
The drawings are electrical circuit diagrams of the same embodiment, FIG. 3 is an explanatory diagram of the use of the same embodiment, and FIG. 4 is a sectional view showing another embodiment of the present invention. 1...Capsule body, 2...Medical capsule, 3...
Cylindrical part, 4... Cap, 5... Battery, 6... Recessed part, 7
...Light emitting element section, 8...LED, 9...Emission end surface, 10
...Resistance, 15...Battery, 16...Rough surface.

Claims (1)

[Scope of Claims] 1. A capsule body that can be placed in a body cavity, a power source built into the capsule body, and a light emitting device provided in the capsule body that emits light by the power source and emits light to the outside of the capsule body. A medical capsule characterized by comprising an element section. 2. The medical capsule according to claim 1, wherein the wavelength distribution of light emitted by the light emitting element has a peak around 630 nm. 3. The medical capsule according to claim 1 or 2, characterized in that the light emitting end face of the light emitting element portion is disposed within a recessed portion recessed from the outer surface of the capsule body. 4. A medical capsule according to claim 1, 2, or 3, characterized in that at least a portion of the outer surface of the capsule body is formed as a rough surface.