CN216192304U - Detection device for nucleic acid amplification product - Google Patents
Detection device for nucleic acid amplification product Download PDFInfo
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- CN216192304U CN216192304U CN202122630259.2U CN202122630259U CN216192304U CN 216192304 U CN216192304 U CN 216192304U CN 202122630259 U CN202122630259 U CN 202122630259U CN 216192304 U CN216192304 U CN 216192304U
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Abstract
The utility model discloses a detection device for a nucleic acid amplification product, which comprises an amplification part and a detection part, wherein the amplification part and the detection part are detachably connected; an amplification cavity is formed in the amplification part, a detection cavity is formed in the detection part, when nucleic acid detection is carried out, a nucleic acid sample and an amplification reagent are placed into the amplification cavity through the first opening, then the first opening is sealed by the sealing unit, and amplification reaction is carried out according to a PCR program to obtain a nucleic acid amplification sample; then, connecting the amplification part with the detection part, wherein the puncture part penetrates through the cavity wall of the detection cavity, so that the nucleic acid amplification sample flows out of the amplification cavity and is in contact with the detection unit, and a detection result is obtained after the reaction to be detected is finished; because the amplification cavity is sealed by the sealing unit when nucleic acid amplification is carried out, the joint of the puncture part and the amplification part is positioned in the detection cavity when nucleic acid detection is carried out, a nucleic acid amplification sample in the amplification cavity cannot be diffused into the environment, and aerosol pollution to the environment is avoided.
Description
Technical Field
The utility model relates to the technical field of nucleic acid detection, in particular to a detection device for a nucleic acid amplification product.
Background
In recent years, with the rapid development of molecular biology techniques, diagnostic methods based on nucleic acid detection have been widely established and widely applied to laboratory detection of human diseases, isothermal amplification technology is one of them, and isothermal amplification has the advantages of rapidness, high efficiency and specificity compared with other nucleic acid amplification technologies and does not need special equipment, so that it is considered by many scholars as a detection method possibly comparable to PCR once it appears. 2019-when the new coronavirus is in a big outbreak, the PCR molecular diagnosis technology is set as the gold standard for detection, but the requirement on a thermal cycler is high, and the detection in the field and the primary hospitals is not facilitated. Thus, scientists have attempted to use alternative exponential amplification techniques, such as loop-mediated isothermal amplification (LAMP), recombinase polymerase amplification, hyperbranched rolling circle amplification, exponential amplification reactions, and exponential strand displacement amplification, among others. The exponential amplification technology reacts under the constant temperature condition without thermal cycle, thereby not only expanding the application scene of the nucleic acid detection technology, but also exciting the potential of POCT application. The molecular diagnosis has the characteristics of high sensitivity and strong specificity, and if the advantages of quick POCT are further integrated, the molecular diagnosis inevitably occupies an important position in the detection field.
POCT refers to a detection mode which is carried out on a sampling site and utilizes a portable analysis instrument and a matched reagent to quickly obtain a detection result. POCT meaning can be understood from two aspects: spatially, tests performed at the patient's side, i.e. "bedside tests"; temporally, a "point-of-care" test can be performed.
The nucleic acid amplification product produced based on the constant temperature amplification technology can perform single molecule nucleic acid detection at a constant and low temperature within 30 min. The current nucleic acid amplification products in China have low requirements on environment and hardware facilities, and have good application in the aspects of biological protection, water body inspection, food inspection, medical diagnosis, microfluid, veterinarian and the like; however, the current nucleic acid amplification products consider the problems of application scenes and cost, and the colloidal gold test strip is used for terminal detection, so that the integration of amplification and test strip detection is realized, the general scene requirements are met, and the cost is reduced, but the product has the defects when being applied to the nucleic acid detection of the new coronavirus: the amplified product needs to be uncovered by a worker, the worker puts the product into a corresponding portable instrument, false positive of detection can be increased, and a laboratory can be polluted, so that the pollution problem caused by the amplified product is solved by generally using a sealing device, however, the amplification stage and the detection stage are not usually positioned in one sealing device, and aerosol pollution to the environment is easily caused.
Namely, the problem of aerosol pollution exists in the nucleic acid amplification product in the prior art.
SUMMERY OF THE UTILITY MODEL
The utility model aims to provide a detection device for a nucleic acid amplification product, which solves the problem of aerosol pollution of nucleic acid amplification products in the prior art.
In order to achieve the purpose, the utility model adopts the following technical scheme:
a detection apparatus for a nucleic acid amplification product, comprising an amplification part and a detection part, the amplification part and the detection part being detachably connected;
an amplification cavity is formed in the amplification part, a first opening is formed in the cavity wall of the amplification cavity, and a sealing unit is detachably connected to the first opening of the amplification part;
a detection cavity is formed in the detection part, and a detection unit and a puncture part are arranged in the detection cavity;
when the amplification part is connected with the detection part, the puncture part penetrates through the cavity wall of the detection cavity, and the joint of the puncture part and the amplification part is positioned in the detection cavity.
Optionally, the detection part comprises an upper detection shell and a lower detection shell which are detachably connected;
when the upper detection shell is connected with the lower detection shell, the upper detection shell and the lower detection shell are in butt-surrounding arrangement to form the detection cavity, and the puncturing part penetrates through the cavity wall of the detection cavity.
Optionally, a limiting part for limiting the position of the amplification part is arranged on the upper detection shell and/or the lower detection shell.
Optionally, a bearing frame for bearing the detection unit is arranged in the detection cavity.
Optionally, a drainage groove is formed in the detection cavity, and the detection unit is arranged in the drainage groove.
Optionally, a drainage unit is disposed between the detection unit and the puncture portion, one end of the drainage unit is connected to the detection unit, and the other end of the drainage unit is connected to the puncture portion.
Optionally, the detection unit comprises a detection test paper.
Optionally, the detection part further includes an observation window disposed on a cavity wall of the detection cavity.
Optionally, the amplification section is a first syringe.
Optionally, a second syringe for storing diluent is further included, and an injection needle of the second syringe can penetrate through the sealing unit and extend into the amplification cavity.
Compared with the prior art, the utility model has the following beneficial effects:
when the detection device for the nucleic acid amplification product provided by the utility model is used for detecting nucleic acid, a nucleic acid sample and an amplification reagent are placed into an amplification cavity through a first opening, then the first opening is sealed by a sealing unit, and then amplification reaction is carried out according to a PCR program to obtain a nucleic acid amplification sample; then, connecting the amplification part with the detection part, wherein the puncture part penetrates through the cavity wall of the detection cavity, so that the nucleic acid amplification sample flows out of the amplification cavity and is in contact with the detection unit, and a detection result is obtained after the reaction to be detected is finished; because the amplification cavity is sealed by the sealing unit when nucleic acid amplification is carried out, the joint of the puncture part and the amplification part is positioned in the detection cavity when nucleic acid detection is carried out, a nucleic acid amplification sample in the amplification cavity cannot be diffused into the environment, and aerosol pollution to the environment is avoided.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive exercise.
The structure, proportion, size and the like shown in the drawings are only used for matching with the content disclosed in the specification, so that the person skilled in the art can understand and read the description, and the description is not used for limiting the limit condition of the implementation of the utility model, so the method has no technical essence, and any structural modification, proportion relation change or size adjustment still falls within the scope of the technical content disclosed by the utility model without affecting the effect and the achievable purpose of the utility model.
FIG. 1 is a schematic diagram showing a side-view explosion structure of a detection apparatus for a nucleic acid amplification product according to an embodiment of the present invention;
FIG. 2 is a schematic top view of the detection apparatus for a nucleic acid amplification product according to the embodiment of the present invention.
Illustration of the drawings: 1. an amplification unit; 11. a first opening; 2. a detection unit; 21. detecting the upper shell; 22. detecting the lower shell; 23. a carrier; 3. a sealing unit; 4. a detection unit; 5. a piercing section; 6. a drainage unit.
Detailed Description
In order to make the objects, features and advantages of the present invention more apparent and understandable, the embodiments of the present invention will be described in detail and completely with reference to the accompanying drawings, and it is to be understood that the embodiments described below are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on those shown in the drawings, and are used only for convenience in describing the present invention and for simplicity in description, and do not indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention. It should be noted that when one component is referred to as being "connected" to another component, it can be directly connected to the other component or intervening components may also be present.
The technical scheme of the utility model is further explained by the specific implementation mode in combination with the attached drawings.
Referring to fig. 1 to 2, fig. 1 is a schematic side view illustrating an explosion structure of a detection apparatus for a nucleic acid amplification product according to an embodiment of the present invention, and fig. 2 is a schematic top view illustrating the structure of the detection apparatus for a nucleic acid amplification product according to an embodiment of the present invention.
The detection device for the nucleic acid amplification product provided by the embodiment is applied to a nucleic acid amplification detection scene, and the structure of the detection device is improved, so that aerosol pollution to the environment can not be caused when the detection device is used for nucleic acid amplification and nucleic acid detection.
As shown in FIGS. 1 and 2, the detection apparatus for a nucleic acid amplification product according to the present embodiment includes an amplification part 1 and a detection part 2, and the amplification part 1 and the detection part 2 are detachably connected.
An amplification cavity is formed in the amplification part 1, a first opening 11 is formed in the cavity wall of the amplification cavity, and the amplification part 1 is detachably connected with a sealing unit 3 at the first opening 11. The sealing unit 3 may be a sealing cover made of an elastic material such as rubber.
A detection cavity is formed in the detection part 2, and a detection unit 4 and a puncture part 5 are arranged in the detection cavity.
When the amplification part 1 is connected to the detection part 2, the puncture part 5 penetrates through the wall of the detection cavity, and the connection part of the puncture part 5 and the amplification part 1 is located in the detection cavity. Wherein, it should be understood that, after the amplification part 1 is connected with the detection part 2, the detection cavity is a sealed cavity, and the amplification part 1 is partially or completely located in the sealed cavity, i.e. the connection part of the puncturing part 5 and the amplification part 1 is located in the detection cavity, thereby preventing the nucleic acid amplification sample in the amplification cavity from leaking to the external environment.
Specifically, when nucleic acid detection is performed, a nucleic acid sample and an amplification reagent are placed in an amplification cavity through a first opening 11, the first opening 11 is sealed by a sealing unit 3, and then amplification reaction is performed according to a PCR (polymerase chain reaction) program to obtain a nucleic acid amplification sample; then, connecting the amplification part 1 with the detection part 2, wherein the puncture part 5 penetrates through the cavity wall of the detection cavity, so that the nucleic acid amplification sample flows out of the amplification cavity and is in contact with the detection unit 4, and a detection result is obtained after the reaction to be detected is finished; because the amplification cavity is sealed by the sealing unit 3 during nucleic acid amplification, the connection part of the puncture part 5 and the amplification part 1 is positioned in the detection cavity during nucleic acid detection, and a nucleic acid amplification sample in the amplification cavity cannot be diffused to the environment, thereby avoiding aerosol pollution to the environment.
Further, the detecting part 2 includes a detecting upper case 21 and a detecting lower case 22 detachably connected.
When the upper detection shell 21 is connected with the lower detection shell 22, the upper detection shell 21 and the lower detection shell 22 are in butt-surrounding arrangement to form a detection cavity, and the puncturing part 5 penetrates through the wall of the detection cavity. It should be added that a sealing ring is further disposed between the upper detection casing 21 and the lower detection casing 22, and the sealing ring can seal a gap between the upper detection casing 21 and the lower detection casing 22.
Illustratively, in the present embodiment, when nucleic acid detection is performed, the amplification part 1 is placed on the detection lower case 22, and the cleavage part 5 is in contact with the amplification part 1 without cleaving the amplification part 1; then, the upper detection case 21 is connected to the lower detection case 22, and at this time, the upper detection case 21 is pressed, so that the amplification part 1 and the puncturing part 5 move relatively, and the puncturing part 5 finally punctures the amplification part 1, and since the upper detection case 21 and the lower detection case 22 are connected, the amplified nucleic acid sample in the amplification part 1 does not leak to the external environment.
Further, the upper detection case 21 and/or the lower detection case 22 are provided with a stopper portion for limiting the position of the amplification part 1. Wherein, the limiting part can limit the position of the amplification part 1, avoid the deviation thereof and ensure that the puncturing part 5 can puncture the amplification part 1.
In a particular embodiment, a carrier 23 for carrying the detection unit 4 is arranged within the detection cavity.
In another specific embodiment, a drainage groove is formed in the detection cavity, and the detection unit 4 is arranged in the drainage groove. This drainage groove plays and guides the effect on detecting element 4 with nucleic acid amplification sample, avoids nucleic acid amplification sample to detecting element 4 outdiffusion, has improved the concentration of nucleic acid amplification sample, has improved detection efficiency, reduces the check-out time.
Further, a drainage unit 6 is arranged between the detection unit 4 and the puncture part 5, one end of the drainage unit 6 is connected with the detection unit 4, and the other end of the drainage unit 6 is connected with the puncture part 5. Specifically, the drainage unit 6 may be a strip-shaped protrusion made of a water-absorbent material such as sponge or cotton, which can make the nucleic acid amplification sample move directionally by using the water-absorbent capacity, thereby preventing the leakage of the nucleic acid amplification sample. Meanwhile, the drainage unit 6 also plays a role of temporarily storing the nucleic acid amplification sample, and can regulate and control the time for the nucleic acid amplification sample to reach the detection unit 4, so that sample washing is prevented (namely, a large amount of nucleic acid amplification samples impact the detection unit 4).
In an alternative embodiment, the test element 4 comprises a test strip, preferably having a width of 0.5mm to 4.0mm, which requires a short reaction time. Additionally, the detection unit 4 may further include a test tube in which a detection liquid is stored.
Further, the detection part 2 further includes an observation window disposed on the cavity wall of the detection cavity. Wherein, the observation window is connected with the cavity wall of the detection cavity in a sealing way.
In this embodiment, the amplification part 1 is a first syringe. Meanwhile, the detection device for the nucleic acid amplification product also comprises a second syringe for storing the diluent, and an injection needle of the second syringe can penetrate through the sealing unit 3 and extend into the amplification cavity. Illustratively, before the upper detection housing 21 is connected to the lower detection housing 22, a diluent may be injected into the amplification chamber through an injection needle of the second syringe, wherein when the injection needle passes through the sealing unit 3, the sealing unit 3 is made of an elastic material, and the insertion or extraction of the injection needle does not affect the sealing performance of the sealing unit 3; after the diluent is injected, the nucleic acid amplification sample is converted into a nucleic acid dilution sample, so that the detection sensitivity is improved; after the second needle tube is pulled out, the amplification part 1 and the detection part 2 are connected to complete the detection reaction of the nucleic acid diluted sample.
In conclusion, the detection device for nucleic acid amplification product provided by the embodiment has the advantages of strong sealing performance, capability of avoiding aerosol pollution to the environment, simple operation, high stability and the like.
The above-mentioned embodiments are only used for illustrating the technical solutions of the present invention, and not for limiting the same; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. A detection device for a nucleic acid amplification product, comprising an amplification part (1) and a detection part (2), wherein the amplification part (1) and the detection part (2) are detachably connected;
an amplification cavity is formed in the amplification part (1), a first opening (11) is formed in the cavity wall of the amplification cavity, and a sealing unit (3) is detachably connected to the amplification part (1) at the first opening (11);
a detection cavity is formed in the detection part (2), and a detection unit (4) and a puncture part (5) are arranged in the detection cavity;
when the amplification part (1) is connected with the detection part (2), the puncture part (5) penetrates through the cavity wall of the detection cavity, and the connection part of the puncture part (5) and the amplification part (1) is positioned in the detection cavity.
2. The apparatus for detecting a nucleic acid amplification product according to claim 1, wherein the detection unit (2) comprises an upper detection case (21) and a lower detection case (22) that are detachably connected;
when the upper detection shell (21) is connected with the lower detection shell (22), the upper detection shell (21) and the lower detection shell (22) are in butt-joint and surround to form the detection cavity, and the puncture part (5) penetrates through the cavity wall of the detection cavity.
3. The apparatus for detecting a nucleic acid amplification product according to claim 2, wherein a stopper for limiting the position of the amplification part (1) is provided on the detection upper case (21) and/or the detection lower case (22).
4. The apparatus for detecting a nucleic acid amplification product according to claim 1, wherein a carrier (23) for carrying the detection unit (4) is provided in the detection chamber.
5. The apparatus for detecting a nucleic acid amplification product according to claim 1, wherein a drainage groove is formed in the detection chamber, and the detection unit (4) is disposed in the drainage groove.
6. The apparatus for detecting a nucleic acid amplification product according to claim 1, wherein a drainage unit (6) is provided between the detection unit (4) and the puncture portion (5), one end of the drainage unit (6) is connected to the detection unit (4), and the other end of the drainage unit (6) is connected to the puncture portion (5).
7. The apparatus for detecting a nucleic acid amplification product according to claim 1, wherein the detection unit (4) comprises a detection strip.
8. The apparatus for detecting a nucleic acid amplification product according to claim 1, wherein the detection unit (2) further comprises an observation window provided on a wall of the detection chamber.
9. The apparatus for detecting a nucleic acid amplification product according to claim 1, wherein the amplification unit (1) is a first syringe.
10. The apparatus for detecting a nucleic acid amplification product according to any one of claims 1 to 9, further comprising a second cartridge for storing a diluent, wherein an injection needle of the second cartridge is capable of penetrating the sealing unit (3) and protruding into the amplification chamber.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122630259.2U CN216192304U (en) | 2021-10-29 | 2021-10-29 | Detection device for nucleic acid amplification product |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202122630259.2U CN216192304U (en) | 2021-10-29 | 2021-10-29 | Detection device for nucleic acid amplification product |
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| CN216192304U true CN216192304U (en) | 2022-04-05 |
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| CN202122630259.2U Active CN216192304U (en) | 2021-10-29 | 2021-10-29 | Detection device for nucleic acid amplification product |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115466671A (en) * | 2022-09-28 | 2022-12-13 | 广纳达康(广州)生物科技有限公司 | Anti-scour liquid nucleic acid amplification product detection device and detection method |
| CN115505515A (en) * | 2022-09-28 | 2022-12-23 | 广纳达康(广州)生物科技有限公司 | Two-section type nucleic acid detection device and detection method |
-
2021
- 2021-10-29 CN CN202122630259.2U patent/CN216192304U/en active Active
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115466671A (en) * | 2022-09-28 | 2022-12-13 | 广纳达康(广州)生物科技有限公司 | Anti-scour liquid nucleic acid amplification product detection device and detection method |
| CN115505515A (en) * | 2022-09-28 | 2022-12-23 | 广纳达康(广州)生物科技有限公司 | Two-section type nucleic acid detection device and detection method |
| CN115466671B (en) * | 2022-09-28 | 2023-12-15 | 广纳达康(广州)生物科技有限公司 | Anti-flushing liquid nucleic acid amplification product detection device and detection method |
| CN115505515B (en) * | 2022-09-28 | 2024-01-23 | 广纳达康(广州)生物科技有限公司 | Two-stage type nucleic acid detection device and detection method |
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Effective date of registration: 20230728 Address after: Room 1-5 / F, building B4, Wuhan National Biological Industry (Jiufeng innovation) base, 666 Gaoxin Avenue, Donghu New Technology Development Zone, Wuhan City, Hubei Province, 430000 Patentee after: WUHAN NANO DIAGNOSIS FOR HEALTH BIOTECHNOLOGY CO.,LTD. Address before: 510000 Room 201, building D, 136 Kaiyuan Avenue, Huangpu District, Guangzhou City, Guangdong Province Patentee before: Guangdong Guangdong Guangdong Hong Kong Macao Dawan District National Nanotechnology Innovation Research Institute |
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Assignee: Guangna Dakang (Guangzhou) Biotechnology Co.,Ltd. Assignor: WUHAN NANO DIAGNOSIS FOR HEALTH BIOTECHNOLOGY CO.,LTD. Contract record no.: X2023980045265 Denomination of utility model: A detection device for nucleic acid amplification products Granted publication date: 20220405 License type: Exclusive License Record date: 20231101 |