CN214781908U - Carrier and bioreactor - Google Patents
Carrier and bioreactor Download PDFInfo
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- CN214781908U CN214781908U CN202121192041.7U CN202121192041U CN214781908U CN 214781908 U CN214781908 U CN 214781908U CN 202121192041 U CN202121192041 U CN 202121192041U CN 214781908 U CN214781908 U CN 214781908U
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Abstract
The utility model provides a carrier and bioreactor, the carrier includes: the bearing structure comprises at least one bearing unit, each bearing unit comprises a first bearing plate and a second bearing plate, the first edge of the first bearing plate is connected with the first edge of the second bearing plate, and the first bearing plate and the second bearing plate are not coplanar; the second edge of the first bearing plate is spaced apart from the second edge of the second bearing plate; the third edge of the first bearing plate is connected with the third edge of the second bearing plate; the fourth edge of the first bearing plate is spaced apart from the fourth edge of the second bearing plate. In the cell culture process, cells grow on the first bearing plate and the second bearing plate, the surface area of the carrier can be increased through the first bearing plate and the second bearing plate, the whole volume of the carrier is small, a large surface area can be provided in a limited space, the cell culture effect is improved, the digestion amplification operation process is facilitated to be simplified, and the cells are easy to digest and are amplified step by step.
Description
Technical Field
The utility model relates to the field of biotechnology, concretely relates to carrier and bioreactor.
Background
In the process of cell culture, adherent cells need to be attached to a carrier for growth, and the carrier for adherent cell culture needs to meet the requirements of carrier surface area, cell density, cell activity and the like. The existing carrier cell culture has poor effect, complicated digestion and amplification operation procedures and no capability of digesting cells and amplifying the cells step by step.
SUMMERY OF THE UTILITY MODEL
In view of this, the utility model provides a carrier and bioreactor for solve the current carrier cell culture's effect not good, the digestion is enlarged operating procedure complicacy, the difficult cell of digestion and enlarge the problem step by step.
In order to solve the technical problem, the utility model discloses a following technical scheme:
in a first aspect, the present invention provides a carrier, comprising: the structure of the load-bearing structure is,
the load bearing structure comprises: the bearing units comprise a first bearing plate and a second bearing plate, the first edge of the first bearing plate is connected with the first edge of the second bearing plate, and the first bearing plate and the second bearing plate are not coplanar;
the second edge of the first bearing plate is spaced apart from the second edge of the second bearing plate;
the third edge of the first bearing plate is connected with the third edge of the second bearing plate;
the fourth edge of the first bearing plate is spaced apart from the fourth edge of the second bearing plate;
the first edge of the first bearing plate is opposite to the second edge of the first bearing plate, and the third edge of the first bearing plate is opposite to the fourth edge of the first bearing plate;
the first edge of the second bearing plate is opposite to the second edge of the second bearing plate, and the third edge of the second bearing plate is opposite to the fourth edge of the second bearing plate.
Each bearing structure comprises a plurality of bearing units, and two adjacent bearing units are connected; and/or
Each bearing structure comprises a plurality of bearing units, two adjacent bearing units in each bearing structure are connected, and the second edge of the second bearing plate in one bearing unit in the two adjacent bearing units is connected with the second edge of the first bearing plate in the other bearing unit; and/or
Each bearing structure comprises a plurality of bearing units, and the third edge of the second bearing plate in one of two adjacent bearing units in each bearing structure is connected with the third edge of the first bearing plate in the other bearing unit.
Wherein, still include:
and each bearing unit is connected with the connecting part.
The third edge of the first bearing plate and the third edge of the second bearing plate in each bearing unit are respectively connected with the connecting part.
Wherein, still include:
the carrier comprises a plurality of bearing structures, and the bearing structures are arranged at intervals along the circumferential direction of the connecting part.
Wherein, still include:
the bearing structure is positioned between the first plate body and the second plate body.
The first plate body is provided with a first flow guide hole penetrating along the thickness direction of the first plate body, and the second plate body is provided with a second flow guide hole penetrating along the thickness direction of the second plate body; and/or
The first plate body and the second plate body are made of transparent materials.
Wherein the first carrier plate comprises at least one of a honeycomb structure, a tubular structure, a pore-like structure, and a lattice structure; and/or
The second bearing plate comprises at least one of a honeycomb structure, a tubular structure, a pore-shaped structure and a grid structure; and/or
The first bearing plate is provided with a first through hole penetrating along the thickness direction of the first bearing plate; and/or
The second bearing plate is provided with a second through hole penetrating along the thickness direction of the second bearing plate; and/or
At least one of the first bearing plate and the second bearing plate comprises a polypropylene material plate or a polyester resin plate.
In a second aspect, the present invention provides a bioreactor comprising:
the carrier described in the above embodiments;
the jar body, the jar has feed inlet and discharge gate on the body, the carrier set up in the jar body.
Wherein, still include:
the stirrer comprises a stirring shaft and stirring blades, wherein the stirring blades are arranged on the stirring shaft, one end of the stirring shaft extends into the tank body, and the stirring blades are positioned in the tank body.
The utility model discloses an above-mentioned technical scheme's beneficial effect as follows:
according to the utility model discloses carrier includes: a load bearing structure, the load bearing structure comprising: the bearing units comprise a first bearing plate and a second bearing plate, the first edge of the first bearing plate is connected with the first edge of the second bearing plate, and the first bearing plate and the second bearing plate are not coplanar; the second edge of the first bearing plate is spaced apart from the second edge of the second bearing plate; the third edge of the first bearing plate is connected with the third edge of the second bearing plate; the fourth edge of the first bearing plate is spaced apart from the fourth edge of the second bearing plate; the first edge of the first bearing plate is opposite to the second edge of the first bearing plate, and the third edge of the first bearing plate is opposite to the fourth edge of the first bearing plate; the first edge of the second bearing plate is opposite to the second edge of the second bearing plate, and the third edge of the second bearing plate is opposite to the fourth edge of the second bearing plate. In the cell culture process, cells can grow on the bearing unit, the cells grow on the first bearing plate and the second bearing plate, the surface area of the carrier can be increased through the first bearing plate and the second bearing plate, the whole volume of the carrier is small, the occupied space is small, a large surface area can be provided in a limited space, the cell culture effect is improved, the digestion amplification operation process is facilitated to be simplified, and the cells are easy to digest and are amplified step by step.
Drawings
Fig. 1 is a schematic structural diagram of a carrier according to an embodiment of the present invention;
fig. 2 is another schematic structural diagram of a carrier according to an embodiment of the present invention;
fig. 3 is a further schematic structural diagram of a carrier according to an embodiment of the present invention;
FIG. 4 is a schematic structural view of a bioreactor according to an embodiment of the present invention;
FIG. 5 is another schematic structural diagram of a bioreactor according to an embodiment of the present invention.
Reference numerals
A first carrier plate 10;
a second carrier plate 20;
a connecting portion 30;
a first plate body 41; a second plate 42;
a tank 50; a stirring shaft 51; the stirring blade 52.
Detailed Description
For further understanding of the present invention, preferred embodiments of the present invention will be described below with reference to examples, but it should be understood that these descriptions are only for the purpose of further illustrating the features and advantages of the present invention, and are not intended to limit the present invention.
As shown in fig. 1 to 5, a carrier according to an embodiment of the present invention includes: bearing structure, bearing structure includes: at least one bearing unit, each bearing unit comprises a first bearing plate 10 and a second bearing plate 20, a first edge 11 of the first bearing plate 10 is connected with a first edge 21 of the second bearing plate 20, and the first bearing plate 10 and the second bearing plate 20 are not coplanar; the second edge 12 of the first loading plate 10 is spaced apart from the second edge 22 of the second loading plate 20, the third edge 13 of the first loading plate 10 is connected to the third edge 23 of the second loading plate 20, and the fourth edge 14 of the first loading plate 10 is spaced apart from the fourth edge 24 of the second loading plate 20, so that a certain gap is formed between the first loading plate 10 and the second loading plate 20, which is beneficial to the flow of the culture solution, and is beneficial to the uniform growth of the cells. The first loading plate 10 and the second loading plate 20 may be substantially quadrilateral, the first edge 11 of the first loading plate 10 is opposite to the second edge 12 of the first loading plate 10, the third edge 13 of the first loading plate 10 is opposite to the fourth edge 14 of the first loading plate 10, the first edge 21 of the second loading plate 20 is opposite to the second edge 22 of the second loading plate 20, and the third edge 23 of the second loading plate 20 is opposite to the fourth edge 24 of the second loading plate 20.
In the process of cell culture, cells can grow on the bearing unit, the cells grow on the first bearing plate 10 and the second bearing plate 20, the surface area of the carrier can be increased through the first bearing plate 10 and the second bearing plate 20, the whole volume of the carrier is small, the occupied space is small, a large surface area can be provided in a limited space, the effect of cell culture is improved, the digestion amplification operation process is facilitated to be simplified, and the cells are easy to digest and are amplified step by step.
In some embodiments, at least one of the first loading plate 10 and the second loading plate 20 has a plurality of protrusions thereon, the plurality of protrusions can be uniformly distributed, and the surface area can be increased by the protrusions, which is advantageous for the growth of cells. At least one of the first loading plate 10 and the second loading plate 20 may have a hole, and the surface area may be increased by the hole, which is advantageous to promote the flow of the culture solution and to culture the cells.
In some embodiments, each bearing structure may include a plurality of bearing units, and two adjacent bearing units are connected with each other.
Alternatively, each of the bearing structures may include a plurality of bearing units, two adjacent bearing units in each of the bearing structures may be connected to each other, the second edge 22 of the second bearing board 20 in one of the two adjacent bearing units may be connected to the second edge 12 of the first bearing board 10 in the other bearing unit, the second edge 12 of the first bearing board 10 in one of the two adjacent bearing units may be spaced apart from the second edge 22 of the second bearing board 20 in the other bearing unit, and the second edge 12 of the first adjacent bearing board 10 and the second edge 22 of the second bearing board 20 may be substantially V-shaped.
Optionally, each carrying structure includes a plurality of carrying units, and the third edge 23 of the second carrying board 20 in one carrying unit of two adjacent carrying units in each carrying structure is connected with the third edge 13 of the first carrying board 10 in another carrying unit. The fourth edge 14 of the first carrier plate 10 and the fourth edge 24 of the second carrier plate 20 adjacent to each other may be substantially V-shaped, which is beneficial to increase the surface area, reduce the overall volume of the carrier, facilitate the flow of the culture solution, and promote the uniform growth of the cells.
In some embodiments, the carrier further comprises: and connecting parts 30, each of the bearing units is respectively connected with the connecting parts 30, and the bearing units can be connected together through the connecting parts 30. Wherein, the third edge 13 of the first loading plate 10 and the third edge 23 of the second loading plate 20 in each loading unit can be connected with the connecting portion 30 respectively. The plurality of bearing units can be distributed along the circumferential direction of the connecting part 30 and can be uniformly distributed, so that the bearing units can be connected together through the connecting part 30 to form a uniform carrier, and uniform growth of cells is facilitated.
In other embodiments, the carrier may further comprise: connecting portion 30, carrier can include a plurality of bearing structure, and a plurality of bearing structure can set up along connecting portion 30's circumference interval, can even interval setting to can link bearing structure together through connecting portion 30 and constitute an even carrier, be favorable to the even growth of cell.
In some embodiments, the carrier may further comprise: first plate body 41 and second plate body 42, first plate body 41 and second plate body 42 can parallel spaced apart the setting, and bearing structure can be located between first plate body 41 and the second plate body 42, can have support and limiting action to bearing structure through first plate body 41 and second plate body 42, and the setting of the carrier of being convenient for is used.
Optionally, the first plate body 41 may be provided with a first flow guiding hole penetrating along the thickness direction of the first plate body 41, the second plate body 42 may be provided with a second flow guiding hole penetrating along the thickness direction of the second plate body 42, and the first flow guiding hole and the second flow guiding hole are favorable for the flow of the culture solution, so that the cells uniformly grow.
Alternatively, the first board 41 and the second board 42 may be transparent materials for easy observation.
In an embodiment of the present invention, the first loading plate 10 may include at least one of a honeycomb structure, a tubular structure, a pore-like structure, and a mesh structure. The second loading plate 20 may include at least one of a honeycomb structure, a tubular structure, a pore-like structure, and a lattice structure. So as to increase the surface area and reduce the whole volume, and is beneficial to the growth of cells.
Optionally, the first loading plate 10 may be provided with a first through hole penetrating along the thickness direction of the first loading plate 10, which is beneficial to the flow of the culture solution, so that the cells can grow uniformly.
Optionally, the second loading plate 20 may be provided with a second through hole penetrating along the thickness direction of the second loading plate 20, which is beneficial to the flow of the culture solution, so that the cells can grow uniformly.
Optionally, at least one of the first carrier plate 10 and the second carrier plate 20 may include a polypropylene material plate or a polyester resin plate, for example, the first carrier plate 10 and the second carrier plate 20 may be polypropylene material plates, which are beneficial to applying charges on the polypropylene material plates, and are beneficial to adsorbing cells by the charges, thereby avoiding the cells from falling off. At least one of the first carrier plate 10 and the second carrier plate 20 can be provided with a charge-applying structure, and charges can be applied to the first carrier plate 10 and the second carrier plate 20 by the charge-applying structure, so that cells can be adsorbed by the charges, and the cells can be prevented from falling off.
The embodiment of the present invention provides a bioreactor, as shown in fig. 4 to 5, the bioreactor may include: carrier and jar body 50 described in the above-mentioned embodiment, can have feed inlet and discharge gate on jar body 50, the carrier can set up in jar body 50, the carrier can be a plurality ofly, can add cell culture liquid in jar body 50, at least part of carrier is located the culture liquid, can cultivate the cell on the carrier, the whole volume of carrier is little, occupation space is little, can provide great surface area in limited space, improve the effect of cell culture, be favorable to simplifying the digestion and enlarge the operation process for the cell is easily digested and enlargies step by step.
In some embodiments, the bioreactor may further comprise: the agitator, the agitator can include (mixing) shaft 51 and stirring paddle 52, and stirring paddle 52 can be established on (mixing) shaft 51, and the one end of (mixing) shaft 51 stretches into jar body 50, and stirring paddle 52 is arranged in jar body 50, is favorable to promoting the flow of culture solution through the agitator, promotes the even of culture solution, is favorable to the even growth of cell.
Unless otherwise defined, technical or scientific terms used herein shall have the ordinary meaning as understood by those of ordinary skill in the art to which the invention belongs. The use of "first," "second," and similar terms in the description herein do not denote any order, quantity, or importance, but rather the terms are used to distinguish one element from another. The terms "connected" or "coupled" and the like are not restricted to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships are changed accordingly.
The foregoing is a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of improvements and decorations can be made without departing from the principle of the present invention, and these improvements and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. A carrier, comprising: the structure of the load-bearing structure is,
the load bearing structure comprises: the bearing units comprise a first bearing plate and a second bearing plate, the first edge of the first bearing plate is connected with the first edge of the second bearing plate, and the first bearing plate and the second bearing plate are not coplanar;
the second edge of the first bearing plate is spaced apart from the second edge of the second bearing plate;
the third edge of the first bearing plate is connected with the third edge of the second bearing plate;
the fourth edge of the first bearing plate is spaced apart from the fourth edge of the second bearing plate;
the first edge of the first bearing plate is opposite to the second edge of the first bearing plate, and the third edge of the first bearing plate is opposite to the fourth edge of the first bearing plate;
the first edge of the second bearing plate is opposite to the second edge of the second bearing plate, and the third edge of the second bearing plate is opposite to the fourth edge of the second bearing plate.
2. The carrier of claim 1, wherein each of said load bearing structures includes a plurality of said load bearing units, and two adjacent ones of said load bearing units are connected to each other; and/or
Each bearing structure comprises a plurality of bearing units, two adjacent bearing units in each bearing structure are connected, and the second edge of the second bearing plate in one bearing unit in the two adjacent bearing units is connected with the second edge of the first bearing plate in the other bearing unit; and/or
Each bearing structure comprises a plurality of bearing units, and the third edge of the second bearing plate in one of two adjacent bearing units in each bearing structure is connected with the third edge of the first bearing plate in the other bearing unit.
3. The carrier of claim 1, further comprising:
and each bearing unit is connected with the connecting part.
4. The carrier as claimed in claim 3, wherein the third edge of the first loading board and the third edge of the second loading board in each of the loading units are respectively connected with the connecting portion.
5. The carrier of claim 1, further comprising:
the carrier comprises a plurality of bearing structures, and the bearing structures are arranged at intervals along the circumferential direction of the connecting part.
6. The carrier of claim 1, further comprising:
the bearing structure is positioned between the first plate body and the second plate body.
7. The carrier of claim 6, wherein the first plate body is provided with a first flow guide hole penetrating along the thickness direction of the first plate body, and the second plate body is provided with a second flow guide hole penetrating along the thickness direction of the second plate body; and/or
The first plate body and the second plate body are made of transparent materials.
8. The carrier according to claim 1, wherein the first carrier plate comprises at least one of a honeycomb structure, a tubular structure, a pore-like structure and a lattice structure; and/or
The second bearing plate comprises at least one of a honeycomb structure, a tubular structure, a pore-shaped structure and a grid structure; and/or
The first bearing plate is provided with a first through hole penetrating along the thickness direction of the first bearing plate; and/or
The second bearing plate is provided with a second through hole penetrating along the thickness direction of the second bearing plate; and/or
At least one of the first bearing plate and the second bearing plate comprises a polypropylene material plate or a polyester resin plate.
9. A bioreactor, comprising:
the vector of any one of claims 1-8;
the jar body, the jar has feed inlet and discharge gate on the body, the carrier set up in the jar body.
10. The bioreactor of claim 9, further comprising:
the stirrer comprises a stirring shaft and stirring blades, wherein the stirring blades are arranged on the stirring shaft, one end of the stirring shaft extends into the tank body, and the stirring blades are positioned in the tank body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121192041.7U CN214781908U (en) | 2021-05-31 | 2021-05-31 | Carrier and bioreactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121192041.7U CN214781908U (en) | 2021-05-31 | 2021-05-31 | Carrier and bioreactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214781908U true CN214781908U (en) | 2021-11-19 |
Family
ID=78699330
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121192041.7U Active CN214781908U (en) | 2021-05-31 | 2021-05-31 | Carrier and bioreactor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214781908U (en) |
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2021
- 2021-05-31 CN CN202121192041.7U patent/CN214781908U/en active Active
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