CN216838017U - Carrier and bioreactor - Google Patents
Carrier and bioreactor Download PDFInfo
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- CN216838017U CN216838017U CN202121454123.4U CN202121454123U CN216838017U CN 216838017 U CN216838017 U CN 216838017U CN 202121454123 U CN202121454123 U CN 202121454123U CN 216838017 U CN216838017 U CN 216838017U
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Abstract
The utility model provides a carrier and bioreactor, the carrier includes: the first plate body is provided with a first opening and a first through hole; the first plate body and the second plate body are arranged in parallel at intervals, a second hole is formed in the position, corresponding to the first hole, of the second plate body, and a second through hole is formed in the position, corresponding to the first through hole, of the second plate body; the first end of body is worn to establish in first through-hole, and the second end of body is worn to establish in the second through-hole that corresponds. In the cell growth process, can place the carrier in the culture solution, the cell can be at the inside wall and the lateral wall growth cell of body, can make the culture solution can flow fully evenly between the body through first trompil and second trompil for the cell can obtain abundant nutrition, and cell culture's is effectual, and it is good to use effect repeatedly, and the digestion enlargies operating procedure simple, is favorable to digesting the cell and enlargies step by step.
Description
Technical Field
The utility model relates to the field of biotechnology, concretely relates to carrier and bioreactor.
Background
In the process of cell culture, adherent cells and suspension cells are generally divided according to cell characteristics, wherein the adherent cells need to be attached to a carrier for growth, and the suspension cells can independently grow. The carrier for adherent cell culture needs to meet the requirements of carrier surface area, cell density, cell activity and the like. The existing carrier has poor cell culture effect, poor repeated use effect, complex digestion and amplification operation procedure and no capability of digesting cells and amplifying the cells step by step.
SUMMERY OF THE UTILITY MODEL
In view of this, the utility model provides a carrier and bioreactor for solve the current carrier cell culture's effect not good, the effect of using repeatedly is not good, and the digestion is enlarged operating procedure complicacy, also can't digest the cell and enlarge the problem step by step.
In order to solve the technical problem, the utility model discloses a following technical scheme:
in a first aspect, the present invention provides a carrier, comprising:
the first plate body is provided with a first opening and a first through hole;
the first plate body and the second plate body are arranged in parallel at intervals, a second hole is formed in the position, corresponding to the first hole, of the second plate body, and a second through hole is formed in the position, corresponding to the first through hole, of the second plate body;
the first end of the pipe body penetrates through the first through hole, and the second end of the pipe body penetrates through the corresponding second through hole.
The first opening is located in the middle of the first plate body, and the second opening is located in the middle of the second plate body.
Wherein the axes of the first plate and the second plate are collinear, and the axis of the first opening is collinear with the axis of the second opening.
The number of the first through holes is multiple, the first through holes are distributed at intervals, the number of the pipe bodies is multiple, the first end of each pipe body penetrates through the corresponding first through hole, and the second end of each pipe body penetrates through the corresponding second through hole.
Wherein the spacing distance between the first plate body and the second plate body is adjustable.
Wherein, the length of body is adjustable.
Wherein, the body includes:
the first end of the first pipe body penetrates through the first through hole;
the first end of the second pipe body penetrates through the second end of the first pipe body, the first end of the second pipe body is arranged in the second end of the first pipe body in a movable mode along the length direction of the first pipe body, and the second end of the second pipe body penetrates through the second through hole.
Wherein the pipe body is a plastic material piece or a glass material piece; and/or
The first plate body and the second plate body are made of plastic materials, glass materials or metal materials; and/or
At least one of the first plate body, the second plate body and the tube body is a transparent material piece; and/or
The inner side wall of the pipe body and/or the outer side wall of the pipe body are/is provided with protrusions distributed at intervals; and/or
The first end of the pipe body is detachably arranged in the first through hole in a penetrating mode, and the second end of the pipe body is detachably arranged in the corresponding second through hole in a penetrating mode; and/or
The tube body is connected with a charge applying structure; and/or
The carrier further comprises a supporting rod, one end of the supporting rod is connected with the first plate body, and the other end of the supporting rod is connected with the second plate body.
In a second aspect, the present invention provides a bioreactor comprising:
the carrier described in the above embodiment;
the jar body, the jar is last to have feed inlet and discharge gate, the carrier set up in the jar body.
Wherein, still include:
the agitator, the agitator includes (mixing) shaft and stirring paddle leaf, stirring paddle leaf establishes on the (mixing) shaft, the one end of (mixing) shaft stretches into in the jar body and pass first trompil with the second trompil, stirring paddle leaf is located in the jar body.
The utility model discloses an above-mentioned technical scheme's beneficial effect as follows:
according to the utility model discloses carrier includes: the first plate body is provided with a first opening and a first through hole; the first plate body and the second plate body are arranged in parallel at intervals, a second hole is formed in the position, corresponding to the first hole, of the second plate body, and a second through hole is formed in the position, corresponding to the first through hole, of the second plate body; the first end of the pipe body penetrates through the first through hole, and the second end of the pipe body penetrates through the corresponding second through hole. In the cell growth process, can place the carrier in the culture solution, the cell can be at the inside wall and the lateral wall growth cell of body, can make the culture solution can flow fully evenly between the body through first trompil and second trompil for the cell can obtain abundant nutrition, and cell culture's is effectual, and it is good to use effect repeatedly, and the digestion enlargies operating procedure simple, is favorable to digesting the cell and enlargies step by step.
Drawings
FIG. 1 is a schematic structural diagram of a carrier according to an embodiment of the present invention;
FIG. 2 is another schematic structural view of a carrier according to an embodiment of the present invention;
FIG. 3 is a schematic view of another embodiment of the carrier;
fig. 4 is a schematic structural diagram of the first plate body;
fig. 5 is a schematic structural view of the second plate;
FIG. 6 is a schematic structural diagram of a bioreactor in an embodiment of the present invention.
Reference numerals
A first plate body 10; a first opening 11; a first through-hole 12;
a second plate body 20; a second opening 21; a second through hole 22;
a tube body 30; a first tube 31; a second tube 32;
a can 40;
a stirring shaft 51; the stirring blade 52;
a support bar 60.
Detailed Description
For a further understanding of the invention, reference will now be made to the following description of the preferred embodiments taken in conjunction with the examples, but it is to be understood that the description is only intended to further illustrate the features and advantages of the invention, and not to limit the invention.
As shown in fig. 1 to 5, the present invention provides a carrier, which comprises a first plate 10, a second plate 20 and a tube 30, wherein the first plate 10 is provided with a first opening 11 and a first through hole 12, the first plate 10 and the second plate 20 are parallel and spaced apart, the specific spacing distance can be selected according to requirements, the first plate 10 and the second plate 20 can be circular plates, the second plate 20 is provided with a second opening 21 corresponding to the first opening 11, the first opening 11 and the second opening 21 can enable a culture solution to flow between the tubes 30 sufficiently and uniformly, so that cells can obtain sufficient nutrition, the second plate 20 is provided with a second through hole 22 corresponding to the first through hole 12, a first end of the tube 30 is inserted into the first through hole 12, a second end of the tube 30 is inserted into the corresponding second through hole 22, the tube 30 can be detached from the first plate 10 and the second plate 20, it is convenient to replace the tube body 30. In the cell growth process, can place the carrier in the culture solution, the cell can be at the inside wall and the lateral wall growth cell of body, can make the culture solution can flow fully evenly between the body through first trompil and second trompil for the cell can obtain abundant nutrition, and cell culture's is effectual, and it is good to use effect repeatedly, and the digestion enlargies operating procedure simple, is favorable to digesting the cell and enlargies step by step.
In some embodiments, the first opening 11 is located in the middle of the first plate 10, and the second opening 21 is located in the middle of the second plate 20. Wherein, the axis collineation of first plate body 10 and second plate body 20, the axis of first trompil 11 and the axis collineation of second trompil 21, the axis of first plate body 10 and the axis of first trompil 11 can the collineation for the culture solution can flow fully evenly between the body, makes the cell can obtain abundant nutrition, and cell culture's is effectual.
In other embodiments, the number of the first through holes 12 is plural, the plural first through holes 12 are distributed at intervals, the plural first through holes 12 can be distributed at intervals around the first opening 11, the plural second through holes 22 can be distributed at intervals around the second opening 21, the number of the tubes 30 can be plural, the first end of each tube 30 can be inserted into the corresponding first through hole 12, and the second end of each tube 30 can be inserted into the corresponding second through hole 22, so that the culture solution can flow between the tubes sufficiently and uniformly, and the cells can obtain sufficient nutrition.
Optionally, the separation distance between the first plate 10 and the second plate 20 can be adjusted to suit different reactors according to the needs of cell culture.
In some embodiments, the length of the tube 30 can be adjusted to adjust the spacing between the first plate 10 and the second plate 20, and to adjust the cell culture requirements to accommodate different reactors.
According to some embodiments, the tube 30 may include a first tube 31 and a second tube 32, wherein a first end of the first tube 31 is inserted into the first through hole 12, a first end of the second tube 32 is inserted into a second end of the first tube 31, a first end of the second tube 32 is movable in a length direction of the first tube 31 in the second end of the first tube 31, and a second end of the second tube 32 is inserted into the second through hole 22, so that the length of the tube 30 is adjustable.
In some embodiments, the tube 30 may be a plastic material or a glass material, such as a polypropylene material or a dacron resin material; and/or
The first plate body 10 and the second plate body 20 are plastic material pieces, glass material pieces or metal material pieces; and/or
At least one of the first plate body 10, the second plate body 20 and the tube body 30 is made of transparent material so as to be convenient for observation; and/or
The inner side wall of the tube body 30 and/or the outer side wall of the tube body 30 are/is provided with protrusions distributed at intervals, the inner side wall of the tube body 30 and/or the outer side wall of the tube body 30 can be uniformly distributed with protrusions, the flow of culture solution can be slowed down through the protrusions, the cells can be prevented from falling off in the cell culture process, the surface area can be increased through the protrusions, and the cell culture quantity and effect can be improved; and/or
A first end of the tube body 30 is detachably inserted into the first through hole 12, and a second end of the tube body 30 is detachably inserted into the corresponding second through hole 22, so as to be replaced as required; and/or
The body can be connected with the structure of imparting charge, can exert electric charge to the body through the structure of imparting charge to the cell adsorbs on the body, reduces droing of cell. The charge imparting structure may include a polypropylene strip through which a charge may be imparted to the tube. The tube body can also be a polypropylene material piece so as to be provided with electric charge and improve the adsorption to cells.
In some embodiments, the carrier may further include a support bar 60, one end of the support bar 60 is connected to the first plate 10, and the other end of the support bar 60 is connected to the second plate 20. The length of the support bar 60 may be adjusted so as to adjust the spaced distance between the first plate 10 and the second plate 20.
As shown in fig. 6, embodiments of the present invention provide a bioreactor, which may include:
the carrier described in the above embodiments;
the jar body 40, jar body 40 is last to have feed inlet and discharge gate, the carrier sets up in jar body 40, can add the culture solution in jar body 40, and the carrier can be arranged in the culture solution to realize the cultivation of cell. A bracket may be provided on an inner sidewall of the tank 40, and a carrier may be placed on the bracket.
In an embodiment of the present invention, the bioreactor may further include: the stirrer may include a stirring shaft 51 and a stirring blade 52, the stirring blade 52 may be disposed on the stirring shaft 51, one end of the stirring shaft extends into the tank 40 and passes through the first opening 11 and the second opening 21, and the stirring blade 52 is disposed in the tank 40. Can stir the culture solution through the agitator for the culture solution evenly flows, and then makes cell culture in-process nutrition even, improves the cultivation effect of cell.
Unless otherwise defined, technical or scientific terms used herein shall have the ordinary meaning as understood by those of ordinary skill in the art to which the invention belongs. The use of "first," "second," and similar terms in the description herein do not denote any order, quantity, or importance, but rather the terms are used to distinguish one element from another. The terms "connected" or "coupled" and the like are not restricted to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships are changed accordingly.
The foregoing is a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of improvements and embellishments can be made without departing from the principle of the present invention, and these improvements and embellishments should also be regarded as the protection scope of the present invention.
Claims (10)
1. A carrier, comprising:
the first plate body is provided with a first opening and a first through hole;
the first plate body and the second plate body are arranged in parallel at intervals, a second hole is formed in the position, corresponding to the first hole, of the second plate body, and a second through hole is formed in the position, corresponding to the first through hole, of the second plate body;
the first end of the pipe body penetrates through the first through hole, and the second end of the pipe body penetrates through the corresponding second through hole.
2. The carrier of claim 1, wherein the first opening is located in a middle portion of the first plate and the second opening is located in a middle portion of the second plate.
3. The carrier of claim 2, wherein the axes of the first plate and the second plate are collinear, and the axis of the first aperture is collinear with the axis of the second aperture.
4. The carrier of claim 1, wherein the number of the first through holes is plural, the plural first through holes are distributed at intervals, the number of the tubes is plural, the first end of each tube is inserted into the corresponding first through hole, and the second end of each tube is inserted into the corresponding second through hole.
5. The carrier of claim 1, wherein a separation distance between the first plate and the second plate is adjustable.
6. The carrier according to claim 1 or 5, wherein the length of the tube is adjustable.
7. The carrier of claim 6, wherein the tube comprises:
the first end of the first pipe body penetrates through the first through hole;
the first end of the second pipe body penetrates through the second end of the first pipe body, the first end of the second pipe body is arranged in the second end of the first pipe body in a movable mode along the length direction of the first pipe body, and the second end of the second pipe body penetrates through the second through hole.
8. The carrier of claim 1 wherein the tube is a piece of plastic material or a piece of glass material; and/or
The first plate body and the second plate body are made of plastic materials, glass materials or metal materials; and/or
At least one of the first plate body, the second plate body and the tube body is a transparent material piece; and/or
The inner side wall of the pipe body and/or the outer side wall of the pipe body are/is provided with protrusions distributed at intervals; and/or
The first end of the pipe body is detachably arranged in the first through hole in a penetrating mode, and the second end of the pipe body is detachably arranged in the corresponding second through hole in a penetrating mode; and/or
The tube body is connected with a charge applying structure; and/or
The carrier further comprises a supporting rod, one end of the supporting rod is connected with the first plate body, and the other end of the supporting rod is connected with the second plate body.
9. A bioreactor, comprising:
the vector of any one of claims 1-8;
the jar body, the jar has feed inlet and discharge gate on the body, the carrier set up in the jar body.
10. The bioreactor of claim 9, further comprising:
the agitator, the agitator includes (mixing) shaft and stirring paddle leaf, stirring paddle leaf establishes on the (mixing) shaft, the one end of (mixing) shaft stretches into in the jar body and pass first trompil with the second trompil, stirring paddle leaf is located in the jar body.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121454123.4U CN216838017U (en) | 2021-06-29 | 2021-06-29 | Carrier and bioreactor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202121454123.4U CN216838017U (en) | 2021-06-29 | 2021-06-29 | Carrier and bioreactor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN216838017U true CN216838017U (en) | 2022-06-28 |
Family
ID=82081514
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202121454123.4U Active CN216838017U (en) | 2021-06-29 | 2021-06-29 | Carrier and bioreactor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN216838017U (en) |
-
2021
- 2021-06-29 CN CN202121454123.4U patent/CN216838017U/en active Active
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