CN214473397U

CN214473397U - Multi-channel fluorescence immunoassay analyzer

Info

Publication number: CN214473397U
Application number: CN202120343506.8U
Authority: CN
Inventors: 钱湧; 许行尚; 杰弗瑞·陈
Original assignee: Nanjing Lanyu Biological Technology Co Ltd
Current assignee: Nanjing Lanyu Biological Technology Co Ltd
Priority date: 2021-02-07
Filing date: 2021-02-07
Publication date: 2021-10-22
Anticipated expiration: 2031-02-07

Abstract

The utility model discloses a multichannel fluorescence immunoassay appearance, including workstation and casing, a accommodation space is constituteed with the casing to the workstation, and sampling device, incubation device, detection device and move back the card device and all locate the accommodation space and install respectively on the workstation, and wherein sampling device is equipped with in the sampling and dials the hand subassembly including advancing the card device, advancing the sample and dialling the hand device and sweeping the sign indicating number device, advancing the sample and dialling the hand device. The sample introduction shifting hand component comprises a second fixed block, a second guide rail, a second sliding block, a sample introduction shifting hand arm, a second limiting rod, a second limiting groove and a sample introduction shifting hand, and a transmission structure formed by the sample introduction shifting hand component is stable and reliable, so that the sample introduction shifting hand can more effectively shift the reagent clamping strip into the incubation device. The installation surface of a detector guide rail in the detection device is parallel to the surface of the workbench. The instrument has compact and more stable structure, reliable operation and accurate positioning, and ensures higher detection efficiency and detection sensitivity.

Description

Multi-channel fluorescence immunoassay analyzer

Technical Field

The utility model relates to a fluorescence detection technology field especially relates to a multichannel fluorescence immunoassay appearance.

Background

The fluorescence immunoassay technology is a technology which combines the specificity and sensitivity of antibody-antigen reaction and the accuracy of micro-tracing, takes fluorescent pigment as a marker to be combined with known antibodies or antigens without influencing the immunological characteristics of the antibodies or antigens, and then takes the antibodies or antigens marked by the fluorescent pigment as standard reagents for detecting and identifying unknown antigens or antibodies.

The specific fluorescence can be directly observed by a fluorescence microscope, or can be received by a photoelectric converter and converted into an electric signal for further processing. Since immunofluorescence assay can accurately, sensitively and rapidly locate and detect some trace or ultra-trace substances, the immunofluorescence technique has been widely applied in many aspects such as immunology, microbiology, pathology, oncology, clinical examination and the like.

Immunofluorescence detection can be carried out through pure manual operation or immunofluorescence analytical equipment in the present stage, the former detection efficiency is low and the precision is not high, the latter only has a station usually, and degree of automation is not high, the inefficiency that the during operation detected, the use cost of equipment is higher, the instrument structure sets up comparatively simply, it is more to need the manual operation step, instrument precision is not enough, the reliability of testing result, stability and sensitivity are poor, have certain influence to the testing result.

Chinese patent CN209372868U discloses a multi-channel fluorescence analyzer, which comprises a sample feeding device, a bar code scanner, a sample feeding hand shifting device, an incubation device, a sample discharging hand shifting device and an optical path detection device. When the detection is started, the sample feeding groove of the sample feeding device reaches the sample feeding position, the reagent card strip is inserted, the reflection-type photoelectric sensor in the sample feeding groove identifies the reagent card strip, the bar code scanner reads bar code information, then the sample feeding groove moves downstream to the optical coupling position, the sample feeding shifting handle shifts the reagent card strip into the incubation groove, the incubation groove is incubated at constant temperature to the incubation time, the incubation device drives the incubation groove to the detection position, the detection device drives the optical path to move to complete data reading, and then the sample discharging shifting handle device directly shifts the detected reagent card strip from the incubation groove.

According to the instrument described in the patent, the light path is arranged right above the detection position, so that the fluorescence detection can be directly carried out on the reagent card strip after the incubation is finished, the transfer step of the reagent card strip is reduced, the probability that the reagent slides or shakes in the reagent card strip is reduced, the analysis result is more accurate and reliable, and the volume of the instrument is effectively reduced. However, the problems that the sample injection hand cannot dial the card, the hand movement is unstable or the card is lost in the midway and the like easily occur in the using process; the problem that the optical signal acquisition is inaccurate and reliable due to the unstable operation of the moving component of the optical detector of the detection device can also occur, and the operation stability and the operation accuracy and reliability of the instrument structure need to be further improved.

SUMMERY OF THE UTILITY MODEL

Therefore, the utility model provides a multichannel fluorescence immunoassay appearance, integrative automated design can assay a series of, the large batch sample that awaits measuring fast, and instrument compact structure and more stable operate the reliable location accurate, make its fluorescence analysis result more accurate, reliable, and stability is high, has guaranteed better detection efficiency and detectivity.

In order to achieve the above purpose, the utility model mainly adopts the following technical scheme:

a multi-channel fluorescence immunoassay analyzer comprises a workbench and a shell, wherein the workbench and the shell form an accommodating space; the sample feeding device, the incubation device, the detection device and the card withdrawing device are all arranged in the accommodating space and are respectively arranged on the workbench; the sample introduction device is used for enabling the reagent card strip sample to enter the sample introduction groove, the incubation device is used for incubating the reagent card strip sample, the detection device is used for carrying out optical detection on the incubated reagent card strip sample, and the card withdrawing device is used for poking the detected reagent card strip sample away; wherein the sample introduction device comprises a card inlet device, a sample introduction shifting handle device and a code scanning device, and a sample introduction shifting handle component is arranged in the sample introduction shifting handle device.

Preferably, the sample introduction hand shifting assembly comprises a second fixed block, a second guide rail, a second sliding block, a sample introduction hand shifting arm, a second limiting rod, a second limiting groove and a sample introduction hand shifting part; the second fixed block is connected with the second guide rail, the second sliding block is connected with the sample injection hand driver through a sample injection hand driver arm, the sample injection hand driver arm is connected with the second limiting rod, the second sliding block is connected with the second guide rail in a sliding mode, and the second sliding block, the second limiting rod, the sample injection hand driver arm and the sample injection hand driver move synchronously; the second limiting groove is arranged on the workbench and controls the second limiting rod to move.

Preferably, the sample feeding hand shifting device further comprises a sample feeding hand shifting limiting device.

Preferably, the detection device comprises an installation support plate, a detector guide rail, a detector sliding block, a sixth connecting block, a detector driving device, a detector screw rod and an optical detector, wherein the installation support plate is installed on the workbench, the detector guide rail is connected to the installation support plate and is in sliding connection with the detector sliding block, the detector sliding block is connected with the optical detector through the sixth connecting block, the detector driving device is installed on the installation support plate and is connected with one end of the detector screw rod and controls the detector screw rod to rotate, the detector screw rod is in threaded transmission connection with the sixth connecting block, and the installation surface of the detector guide rail is parallel to the surface of the workbench. More preferably, the detection means further comprises detector limiting means for limiting the movement of the optical detector.

Preferably, the incubation device comprises an incubation tray stop. More preferably, the incubation device comprises an incubation tray provided with a pellet.

Preferably, the card withdrawing device comprises a card withdrawing and shifting hand limiting device and a card withdrawing inclined plane, wherein the card withdrawing and shifting hand limiting device is used for controlling the movement limiting of the card withdrawing and shifting hand, the card withdrawing inclined plane is installed on the workbench, and the reagent card strip sample is separated by the card withdrawing and shifting hand and then slides off through the card withdrawing inclined plane.

Preferably, the multichannel fluorescence immunoassay analyzer further comprises a printing device and a display device, wherein the display device is used for displaying the detection information of the reagent card strip sample, and the printing device is used for outputting the detection information of the reagent card strip sample.

Compared with the prior art, the beneficial effects of the utility model are that:

in the application, the sample introduction hand shifting assembly in the sample introduction hand shifting device adopts a connection mode of a multi-connecting-block and sliding-block guide rail structure, the mechanical stability of the transmission structure is higher and more reliable, and the sample introduction hand shifting device can effectively shift the reagent clamping strip into the incubation device; the motion assembly of the detection device runs more stably, the optical signal acquisition is more reliable, and the operation stability and the accuracy reliability of the instrument structure are improved.

Drawings

FIG. 1 is a schematic view of the appearance of the multi-channel fluorescence immunoassay analyzer;

FIG. 2 is a schematic view of the whole fluorescence immunoassay analyzer with the housing removed;

FIG. 3 is a first schematic structural diagram of a card feeding device of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 4 is a schematic structural diagram of a card feeding device of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 5 is a schematic diagram of a position-limiting sensor of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 6 is a schematic structural view of a card-feeding position-limiting component of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 7 is a schematic structural diagram I of a sample feeding hand shifting device of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 8 is a schematic structural view of a sample feeding hand pusher of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 9 is a schematic view of the sample injection device of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 10 is a schematic structural diagram of an incubation device of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 11 is a schematic structural view of an incubation device of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 12 is a schematic view of the structure of an incubation tray of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 13 is a schematic structural view of a detecting device of the multi-channel fluorescence immunoassay analyzer of the present invention;

FIG. 14 is a schematic structural view of a card withdrawing device of the multi-channel fluorescence immunoassay analyzer of the present invention;

fig. 15 is a top view of the internal structure of the multi-channel fluorescence immunoassay analyzer.

Description of the reference numerals

The sample feeding device 1, the incubation device 2, the detection device 3, the card withdrawing device 4, the printing device 5, the display device 6, the workbench 7, the shell 8, the reagent card strip 9, the sample inlet 10, the card feeding device 11, the sample introduction hand dialing device 12, the code scanner 13, the code scanning bracket 14, the card withdrawing box 15, the incubation disc bracket 21, the incubation disc guide rail 22, the incubation disc slide block 23, the fifth connecting block 24, the incubation disc 25, the detector guide rail 32, the detector slide block 33, the sixth connecting block 34, the detector motor 35, the detector lead screw 36, the optical detector 37, the detector limit baffle 38, the shielding cover 39, the detector limit optical coupler 40, the card withdrawing device bracket 41, the card withdrawing guide rail 42, the card withdrawing slide block 43, the seventh connecting block 44, the card withdrawing hand dialing device 45, the card withdrawing hand dialing driving device 46, the card dialing hand limit device 47, the card withdrawing bevel 48, the sample feeding base 1101, the sample introduction guide rail 1102, a sample introduction slide block 1103, a first connection block 1104, a supporting plate 1105, a second connection block 1106, a sample introduction slot 1107, a sample introduction slot driving device/sample introduction motor 1108, a sample introduction screw 1109, a screw nut 1110, a card introduction limiting component 1111, a first fixing block 1112, a first guide rail 1113, a first slide block 1114, a card introduction limiting column 1115, a first limiting rod 1116, a first limiting groove 1117, a limiting groove support 1118, a limiting sensor 1119, a positioning convex column 1120, a connection member 1121, a mounting support plate 1201, a sample introduction hand dialing motor 1202, a sample introduction hand dialing guide rail 1203, a sample introduction hand dialing slide block 1204, a third connection block 1205, a fourth connection block 1206, a second fixing block 1207, a sample introduction hand dialing limiting baffle 1208, a first driving wheel 1209, a first driven wheel 1210, a first synchronous belt 1211, a sample introduction hand dialing limiting optical coupler 1212, a second guide rail 1213, a second slide block 1214, a sample introduction hand dialing arm 1215, a second limiting rod 1216, a second limiting groove 1217, a sample introduction hand dialing 1218, incubation groove 2501, pressing sheet 2502, heating sheet 2503, incubation tray motor 2601, second driving wheel 2602, second driven wheel 2603, second synchronous belt 2604, belt connecting device 2605, incubation tray limit baffle 2701, incubation tray limit optical coupler 2702, card withdrawing and poking hand motor 4601, third driving wheel 4602, third driven wheel 4603, third synchronous belt 4604, card withdrawing and poking hand limit baffle 4701, card withdrawing and poking hand limit optical coupler 4702

Detailed Description

The following description of the embodiments of the present invention will be described in more detail with reference to the drawings. The advantages and features of the present invention will become more apparent from the following description. It should be noted that the drawings are in simplified form and are not to precise scale, and are provided for convenience and clarity in order to facilitate the description of the embodiments of the present invention.

Fig. 1 and fig. 2 show the overall appearance of the multichannel fluorescence immunoassay analyzer and the overall structure of the multichannel fluorescence immunoassay analyzer after the casing is removed. As shown in the figure, the multichannel fluorescence immunoassay analyzer comprises a sample introduction device 1, an incubation device 2, a detection device 3, a card withdrawing device 4, a printing device 5, a display device 6, a workbench 7, a shell 8, a sample introduction port 10 and a card withdrawing box 15, wherein the workbench 7 is positioned on the bottom surface of the whole structure, the upper surface of the workbench 7 is a horizontal plane, the periphery of the workbench 7 is connected with the shell 8 to jointly construct an accommodating space, and the sample introduction device 1, the incubation device 2, the detection device 3, the card withdrawing device 4, the printing device 5 and the display device 6 are all positioned in the accommodating space. The right front of the containing space is area A, the right back is area B, the left back is area C, and the left front is area D.

The sample introduction device 1 is located in the area a of the accommodating space, and includes a card introduction device 11, a sample introduction hand dialing device 12 and a code scanning device, and is used for completing sample introduction of the reagent card strip and conveying the reagent card strip to the next procedure. The card feeding device 11 is arranged on the workbench 7 and is positioned in the area A of the accommodating space; the sample feeding hand shifting device 12 is arranged on the workbench 7 and spans two regions A, B of the accommodating space, one end of the sample feeding hand shifting device is positioned in the region A and close to the card feeding device 11, and the other end of the sample feeding hand shifting device is positioned in the region B and close to the incubation device 2 and the detection device 3; the code scanning device is located in the area A, fixedly connected to one end of the sample feeding hand shifting device 12 and located above the card feeding device 11 and the sample feeding hand shifting device 12. The incubation device 2 and the detection device 3 are located in the area B of the accommodating space, and the detection device 3 is arranged above the incubation device 2.

Fig. 3 and 4 show a schematic structural diagram of the card entering device 11 of the multi-channel fluorescence immunoassay analyzer; FIG. 5 shows a schematic structural diagram of the position-limiting sensor 1119 of the multi-channel fluorescence immunoassay analyzer; fig. 6 shows a schematic structural diagram of the card-entering limiting component 1111 of the multi-channel fluorescence immunoassay analyzer. As shown in the figure, the card feeding device 11 includes a sample feeding base 1101, a sample feeding guide rail 1102, a sample feeding slider 1103, a first connecting block 1104, a supporting plate 1105, a second connecting block 1106, a sample feeding slot 1107, a sample feeding slot driving device 1108, a sample feeding screw 1109, a screw nut 1110, and a card feeding limit component 1111. The sample introduction base 1101 is fixedly installed on the workbench and is used for supporting the whole card feeding device 11. The sample introduction guide rail 1102 is fixedly connected to the upper surface of the sample introduction base 1101, and is in sliding connection with the sample introduction slider 1103, one end of the sample introduction guide rail 1102 is a sample introduction position, and the other end of the sample introduction guide rail 1102 is an optical coupling position. The sample injection slider 1103 sequentially passes through the first connecting block 1104, the supporting plate 1105 and the second connecting block 1106 to be fixedly connected with the sample injection groove 1107 into a whole, that is, all parts fixedly connected with the sample injection slider 1103 into a whole can move synchronously.

The sample injection groove 1107 is used for inserting the reagent card strip 9, a positioning convex column 1120 is arranged at the inner side of the sample injection groove 1107, and the positioning convex column 1120 is used for matching with a groove structure of the reagent card strip 9 to position the reagent card strip 9 in the sample injection groove 1107; a limit sensor 1119 is arranged below the sample inlet groove 1107, the limit sensor 1119 is fixed on the supporting plate 1105 through a connecting piece 1121 for identifying whether the reagent card strip 9 is in place, and the detection reagent card strip 9 is in place and then transmits a signal to enable the instrument to start the next operation. The sample injection slot driving device, preferably the sample injection motor 1108, is disposed on the sample injection base 1101 and close to one end of the sample injection guide rail 1102, and is configured to drive the sample injection slot 1107 to slide between the sample injection position and the optical coupling position along the sample injection guide rail 1102, and a power output end of the sample injection motor 1108 is connected to a sample injection screw 1109. One end of the sample feeding screw 1109 is connected with a sample feeding motor 1108, the other end of the sample feeding screw 1109 is in threaded fit connection with a screw nut 1110 on a supporting plate 1105, the installation direction of the sample feeding screw is parallel to the sample feeding guide rail 1102, the sample feeding screw 1109 rotates under the control of the sample feeding motor 1108, and then all parts which are fixedly connected with the screw nut 1110 into a whole can be driven to move relative to the sample feeding screw 1109, namely, the sample feeding slide block 1103 is driven to slide along the sample feeding guide rail 1102, and the movement control of the sample feeding groove 1107 between the sample feeding position and the optical coupling position along the direction of the sample feeding guide rail 1102 is also realized.

The card feeding limiting component 1111 is arranged at one end close to the sample feeding groove 1107 and far away from the sample feeding port, and is used for preventing the reagent card strip 9 from being excessively inserted when being inserted into the sample feeding groove 1107, and the card feeding limiting component 1111 comprises a first fixing block 1112, a first guide rail 1113, a first sliding block 1114, a card feeding limiting column 1115, a first limiting rod 1116, a first limiting groove 1117 and a limiting groove support 1118. The first fixing block 1112 is fixedly connected to the supporting plate 1105, and is configured to carry a first guide rail 1113, a first slider 1114, a card-entering limiting post 1115, and a first limiting rod 1116 of the card-entering limiting assembly. The first guide rail 1113 is fixedly connected to the first fixing block 1112 perpendicular to the upper surface of the workbench, and is used for being matched and connected with the first sliding block 1114. The first sliding block 1114 can slide up and down relative to the first guide rail 1113, the first sliding block 1114 is fixedly connected with a card-entering limiting post 1115, the card-entering limiting post 1115 is provided with a first limiting rod 1116, and the first sliding block 1114, the card-entering limiting post 1115 and the first limiting rod 1116 are fixedly connected into a whole and can synchronously slide along the first guide rail 1113. The card-feeding limiting column 1115 is close to one end face of the sample injection groove 1107 far away from the sample injection port, and is used for preventing the reagent card strip 9 from being excessively inserted in the insertion process. The first limiting rod 1116 is disposed on the sample injection limiting column 1115 and moves in cooperation with the first limiting groove 1117, and the first limiting rod 1116 controls the card injection limiting column 1115 to move up and down according to the path of the first limiting groove 1117. First spacing groove 1117 passes through spacing groove support 1118 fixed mounting on the workstation, the route in first spacing groove 1117 sets up to be by high-order to low level, this low level end is close to the incubation device, it is used for controlling the slip path of inside first gag lever post 1116, in the process of advancing the groove 1107 from advancing the appearance position to opto-coupler position and sliding, first gag lever post 1116 drives advance kind spacing post 1115 and slides to the extreme low that is close to the incubation device by initial high-order through first slider 1114 relative first guide rail 1113, it dials reagent card strip 9 to corresponding incubation device unhindered to advance kind the hand.

Fig. 7 and fig. 8 show the structural schematic diagram of the sample injection hand-setting device 12 of the multi-channel fluorescence immunoassay analyzer. As shown in the figure, the sample feeding hand shifting device 12 includes an installation support plate 1201, a sample feeding hand shifting driving device, a sample feeding hand shifting guide rail 1203, a sample feeding hand shifting slider 1204, a third connection block 1205, a fourth connection block 1206, a sample feeding hand shifting assembly, and a sample feeding hand shifting limiting device. The mounting plate 1201 is a planar structure, and is fixedly mounted on the workbench to serve as a base frame for bearing the sampling hand-shifting device 12. The sample feeding hand driving device is used for driving the sample feeding hand 1218 to feed the reagent card strip inserted into the sample feeding slot to the incubation device, and preferably, the sample feeding hand driving motor 1202, the first driving wheel 1209, the first driven wheel 1210 and the first synchronous belt 1211 are used for driving the sample feeding hand 1218. The sample injection hand poking motor 1202 can be installed according to the actual space utilization requirement of the instrument, preferably, an output shaft of the sample injection hand poking motor 1202 is installed in a direction perpendicular to the upper surface of the workbench, the output shaft is fixedly connected with the first driving wheel 1209 and is connected with the first driven wheel 1210 through the first synchronous belt 1211, and the first synchronous belt 1211 is fixedly connected with the third connecting block 1205 to drive the sample injection hand poking 1218 to slide relative to the sample injection hand poking guide rail 1203. The sample injection hand shifting guide 1203 is fixedly connected to the mounting support plate 1201, is parallel to the sample injection guide, and is in sliding connection with the sample injection hand shifting slider 1204. The sample introduction hand shifting sliding block 1204 can slide along the direction of the sample introduction hand shifting guide rail 1203, the sample introduction hand shifting sliding block 1204 sequentially passes through the third connecting block 1205 to be fixedly connected with the fourth connecting block 1206 as a whole, namely all parts fixedly connected with the sample introduction hand shifting sliding block 1204 can synchronously move together, wherein the third connecting block 1205 is used for connecting a first limiting device, the fourth connecting block 1206 is used for connecting a sample introduction hand shifting assembly, the third connecting block 1205 and the fourth connecting block 1206 can also be combined into a part to be applied as an integral connecting block, and the adaptive modification can be carried out according to actual needs.

The sample injection hand-setting assembly comprises a second fixing block 1207, a second guide rail 1213, a second slide block 1214, a sample injection hand-setting arm 1215, a second limit rod 1216, a second limit groove 1217 and a sample injection hand-setting 1218. The second fixing block 1207 is used to carry a second guide rail 1213, a second slider 1214, a sample hand-pulling arm 1215, a second limit rod 1216 and a sample hand-pulling 1218, and is fixedly connected to the fourth connecting block 1206, and is fixedly connected to the second guide rail 1213 as a whole and can move synchronously with the sample hand-pulling slider 1204. The second guide 1213 is fixedly connected to the second fixing block 1207 in a direction perpendicular to the upper surface of the table, and is slidably connected to the second slider 1214, so that the second slider 1214 can slide up and down relative to the second guide 1213. The second slider 1214 is fixedly connected to the sample hand dial 1218 via the sample hand dial 1215, and the sample hand dial 1215 is fixedly connected to the second position-limiting rod 1216, that is, the second position-limiting rod 1216, the sample hand dial 1215 and the sample hand dial 1218 can move synchronously with the second slider 1214. The second stopper 1216 can control the up and down movement of the sampling hand 1218 according to the inner path of the second stopper 1217. The second limiting groove 1217 is fixedly connected to the mounting plate 1201, and is used for controlling the sliding path of the second limiting rod 1216, the path inside the second limiting groove 1217 is set from a high position to a low position, the high position end is close to the card feeding device, so that the height of the sample feeding hand dial 1218 is higher than the upper surface of the reagent card strip in the sample feeding groove, when the reagent card strip is inserted into the preset position of the sample feeding groove, the sample feeding hand dial driving device controls the movement of the sample feeding hand dial assembly, the second limiting rod 1216 controls the sample feeding hand dial 1218 to slide downwards from the initial high position, and the sample feeding hand dial 1218 can dial the reagent card strip to move towards the incubation device when sliding to the low position. The initial position of the sample injection hand 1218 is close to the sample inlet, and slides from the high position to the low position under the control of the sample injection hand driving device, and is connected with the second fixed block 1207 through the second slide block 1214 and the second guide rail 1213, the transmission structure is stable and reliable, and the reagent card strip in the sample injection groove can be effectively inserted into the incubation device. Advance kind and dial a hand stop device and be used for realizing advancing the spacing of kind dial 1218, this stop device includes advancing kind dial a hand spacing separation blade 1208 and advances kind dial a hand spacing opto-coupler 1212. One end of the sampling hand-shifting limiting baffle 1208 is fixedly connected to the third connecting block 1205, and the other end of the sampling hand-shifting limiting baffle can be used in cooperation with the sampling hand-shifting limiting optocoupler 1212. The sample feeding hand pulling limiting optical coupler 1212 is preferably a slot-shaped optical coupler, and is fixedly installed at a specific position of the structure according to design, and in this embodiment, is installed at a specified position of the installation support plate 1201. When the sampling hand-setting limiting blocking piece 1208 is blocked in the middle of the groove-shaped optical coupler groove, the transmitting side and the receiving side of the groove-shaped optical coupler cannot be conducted, and this state indicates that the sampling hand-setting limiting blocking piece 1208 reaches a limiting point, because the sampling hand-setting limiting blocking piece 1208 and the sampling hand-setting 1218 slide synchronously with the sampling hand-setting slider 1204, the movement limitation of the sampling hand-setting 1218 is also realized.

Fig. 9 shows a schematic structural diagram of the sample injection device 1 of the multi-channel fluorescence immunoassay analyzer. As shown in the figure, the code scanning device of the sample injection device 1 includes a code scanning device 13 and a code scanning bracket 14, the code scanning device 13 is fixedly connected to the mounting support plate 1201 of the sample injection hand-shifting device 12 through the code scanning bracket 14, and is close to the sample injection port and located above the sample injection groove 1107, after the reagent card strip 9 is inserted into the sample injection groove 1107, the code scanning device 13 scans the two-dimensional code of the reagent card strip 9, and identifies information such as detection items and production lot numbers of the reagent card strip 9, and stores the information into the instrument.

FIGS. 10 and 11 are schematic views showing the structure of the incubation apparatus 2 of the multi-channel fluorescence immunoassay analyzer; FIG. 12 shows a schematic diagram of the structure of the incubation tray 25 of the multi-channel fluorescence immunoassay analyzer described above. The incubation device 2 is the next process of the sample introduction device and is used for incubating the reagent card strip sample introduced by the sample introduction device. As shown, the incubation device 2 includes an incubation disk device holder 21, an incubation disk guide 22, an incubation disk slider 23, a fifth connecting block 24, an incubation disk 25, an incubation disk drive device, and an incubation disk limit device. An incubation plate means holder 21 is fixedly mounted on the table for carrying the entire incubation means 2. The incubation tray guide rail 22 is fixedly connected with the incubation tray device bracket 21, the incubation tray 25 can slide along the installation direction of the incubation tray, the installation direction of the incubation tray is vertical to the sample feeding guide rail, the incubation tray guide rail 22 is provided with a detection position, and the optical coupler part of the sample feeding guide rail is arranged adjacent to the detection position. The incubation disk sliding block 23 is connected with the incubation disk guide rail 22 in a sliding manner and is fixedly connected with the incubation disk 25 into a whole through a fifth connecting block 24, namely the fifth connecting block 24 and the incubation disk 25 can move synchronously with the incubation disk sliding block 23, and the incubation disk sliding block 23 drives the incubation disk 25 to slide to a detection position.

The incubation tray 25 is composed of a plurality of

incubation grooves

2501, 8 incubation grooves 2501 are exemplarily shown in the drawing, but the number of the incubation grooves 2501 is not limited to 8 in practice. The direction of the incubation groove 2501 is parallel to the direction of the sample feeding groove, the incubation groove 2501 is used for receiving the reagent card strip 9 in the sample feeding groove, and the reagent card strip 9 is fixed by the two pressing sheets 2502, thereby effectively ensuring that the reagent card strip 9 can not deviate in the incubation groove 2501. The heat patch 2503 is disposed under the incubation tray 25, and the temperature sensor is disposed to precisely control the incubation temperature of the reagent card strip 9 so as to keep the incubation chamber 2501 at a constant temperature, and when the incubation time is over, the incubation chamber 2501 is moved to the detection position for optical detection. The incubation tray driving device is used for driving the incubation tray 25 to slide along the incubation tray guide rail 22 so as to slide the incubation slot 2501 to the detection position, and preferably adopts an incubation tray motor 2601, a second driving wheel 2602, a second driven wheel 2603 and a second synchronous belt 2604, wherein the second synchronous belt 2604 is fixedly connected with the incubation tray 25 into a whole through a belt connecting device 2605, i.e. the second synchronous belt 2604 drives the incubation tray 25 to slide along the incubation tray guide rail 22 when rotating. The incubation disc limiting device is used for limiting the movement of the incubation disc 25, preferably an incubation disc limiting baffle 2701 and an incubation disc limiting optical coupler 2702 are adopted, one end of the incubation disc limiting baffle 2701 is fixedly connected to the incubation disc 25, the other end of the incubation disc limiting baffle 2702 can be matched with the incubation disc limiting optical coupler 2702 for use, the incubation disc limiting optical coupler 2702 is preferably a groove-shaped optical coupler, when the incubation disc limiting baffle 2701 is blocked in the middle of a groove-shaped optical coupler groove, the transmitting side and the receiving side of the groove-shaped optical coupler cannot be conducted, when the state occurs, the incubation disc limiting baffle 2701 reaches a limiting point, the incubation disc limiting baffle 2701 and the incubation disc 25 synchronously slide, and therefore the movement limiting of the incubation disc 25 is achieved.

Fig. 13 shows a schematic structural diagram of the detection device 3 of the multi-channel fluorescence immunoassay analyzer. The detection device 3 is a next step of the incubation device, and is used for optically detecting the incubated reagent card strip sample. As shown in the figure, the detection device 3 includes a mounting plate 1201, a detector guide rail 32, a detector slider 33, a sixth connection block 34, a detector driving device, a detector screw 36, an optical detector 37, and a detector limiting device. The mounting support plate 1201 is fixedly mounted on the workbench and used for bearing and mounting the detection device 3, in this embodiment, the detection device 3 and the sample injection hand-shifting device share the same mounting support plate 1201, but the two devices may not share the same mounting support plate. The detector guide rail 32 is fixedly connected to the mounting support plate 1201, the mounting direction of the detector guide rail 32 is parallel to the sample feeding guide rail, the detector guide rail is connected with the detector sliding block 33 in a sliding mode, the mounting surface of the detector guide rail 32 is parallel to the upper surface of the workbench, namely the detector sliding block 33 slides along the upper portion of the detector guide rail 32 arranged on the plane, the mounting mode enables the light path of the detector in the sliding motion to be more stable, the light path collection to be more stable, and the detection result to be more stable and reliable. The detector slide block 33 can slide along the upper part of the detector guide rail 32 arranged on the plane, and is fixedly connected with the optical detector 37 into a whole through a sixth connecting block 34, namely the optical detector 37 and the detector slide block 33 move synchronously. The detector driving device is used for driving the detector slide block 33 to slide along the detector guide rail 32 so as to detect the reagent card strip sample in the incubation groove, and is fixedly arranged on the mounting plate 1201, and a detector motor 35 is preferably adopted in the embodiment, and the direction of a power output shaft is parallel to the direction of the detector guide rail 32. One end of the detector screw rod 36 is connected to an output shaft of the detection motor 35, the detection motor 35 controls the detector screw rod 36 to rotate, and the detector screw rod 36 and the sixth connecting block 34 form a threaded transmission connection, so that the optical detector 37 is driven to move. The optical detector 37 is located right above the detection position, fixedly connected with the sixth connecting block 34 and the detection slide block 33 into a whole, slides back and forth along the detector guide rail 32 along with the detection slide block 33, and is parallel to the direction of the incubation groove, and is used for detecting the reagent card strip sample located right below the optical detector and at the detection position and reading data. Outside the optical detector 37 is a shield 39, and the shield 39 shields the detection result from ambient light. Detector stop device is used for spacing to the motion of optical detector 37, including the spacing opto-coupler of detector 38 and detector 40, detector 38 one end fixed connection is on sixth connecting block 34, its other end can use with the spacing opto-coupler of detector 40 cooperation, the preferred flute profile opto-coupler of the spacing opto-coupler of detector 40, keep off when the flute profile opto-coupler groove is middle when detector 38, the transmission side and the receiving side of flute profile opto-coupler can not switch on, it has reachd spacing point to explain when this state takes place that detector 38 has arrived spacing, because of detector 38 slides with optical detector 37 in step, it is spacing also to the motion of optical detector 37 to have realized.

FIG. 14 is a schematic structural diagram of the card ejecting device 4 of the multi-channel fluorescence immunoassay analyzer; fig. 15 shows a top view of the internal structure of the multi-channel fluorescence immunoassay analyzer. The card withdrawing device 4 is a next step of the detection device, and is used for removing the detected reagent card strip sample from the incubation groove. As shown in the figure, the card ejecting device 4 includes a card ejecting device bracket 41, a card ejecting guide rail 42, a card ejecting slider 43, a seventh connecting block 44, a card ejecting handle 45, a card ejecting handle driving device 46, a card ejecting handle limiting device 47, and a card ejecting inclined plane 48. The card ejector bracket 41 is fixedly mounted on the workbench and is used for bearing the whole card ejector 4. The card withdrawing guide rail 42 is fixedly connected to the card withdrawing device bracket 41, the installation direction of the card withdrawing guide rail is parallel to that of the sample injection guide rail, the installation surface of the card withdrawing guide rail 42 is parallel to the upper surface of the workbench, namely, the card withdrawing slide block 43 slides above the card withdrawing guide rail 42 arranged along the plane. The card withdrawing slide block 43 is fixedly connected with the seventh connecting block 44 and the card withdrawing pusher 45 into a whole, that is, the card withdrawing slide block 43 can drive the card withdrawing pusher 45 and the seventh connecting block 44 to move synchronously. The card withdrawing driving device 46 is used for driving the card withdrawing driving device 45 to slide back and forth along the card withdrawing guide rail 42 to withdraw the sample of the reagent card strip in the incubation groove, and is fixedly arranged on the card withdrawing device bracket 41, in this embodiment, the card withdrawing driving device 46 preferably adopts a card withdrawing driving motor 4601, a third driving wheel 4602, a third driven wheel 4603 and a third synchronous belt 4604, wherein the third synchronous belt 4604 is fixedly connected with the seventh connecting block 44 to drive the card withdrawing driving device 45 to slide along the card withdrawing guide rail 42. Move back card and dial stop device 47 and be used for controlling move spacing of moving back card and dial 45, including moving back card and dial limit baffle 4701 and moving back card and dial limit optical coupler 4702, move back card and dial limit baffle 4701 one end fixed connection on seventh connecting block 44, its other end can with move back card and dial limit optical coupler 4702 cooperation use, move back the card and dial the preferred flute profile optical coupler of limit optical coupler 4702, when moving back card and dial limit baffle 4701 and keeping off in the middle of the flute profile optical coupler groove, the transmitting side and the receiving side of flute profile optical coupler can not switch on, it explains when this state takes place that move back card and dial limit baffle 4701 and arrived the limit point, move back card and dial limit baffle 4701 and move back card and dial 45 synchronous slippage, also realized moving spacing to moving back card and dial 45. The card withdrawing slope 48 is fixedly installed on the workbench through a connecting structure, and after the detection of the sample of the reagent card strip is completed, the card withdrawing and poking hand 45 directly pokes away the reagent card strip in the incubation groove, and the reagent card strip slides into the card withdrawing box 15 through the card withdrawing slope 48.

As shown in fig. 1, the printing device 5 and the display device 6 are located on the upper surface of the whole structure casing 8, and they are arranged adjacently. The printing device 5 can output the sample detection information by a paper carrier, the display device 6 can be a touch-operable display screen and can be obliquely arranged, and the display device faces an operator under the normal working state of the fluorescence immunoassay analyzer. The display device 6 and the printing device 5 can facilitate the user to see the detection information instantly and transmit the information by a paper carrier, thereby facilitating the user.

The operation mode of the multi-channel fluorescence immunoassay analyzer is as follows: when the detection is started, a sample to be detected is added into a sample adding port of a reagent card strip 9, the reagent card strip 9 is inserted into a sample adding groove 1107 through a sample adding port 10, the reagent card strip 9 is inserted into a position, namely, when the sample adding position is limited by a card adding limiting column 1115, a limiting sensor 1119 below the sample adding groove 1107 identifies the inserted reagent card strip 9, then a code scanner 13 scans and reads a two-dimensional code on the reagent card strip 9, the sample adding device 1 is started, a sample adding motor 1108 drives the sample adding groove 1107 to stop from the sample adding position to an optical coupler position, then a sample adding hand dialing motor 1202 operates, so that a sample adding hand 1218 is driven to slide from a high position to a low position along a second limiting groove 1217, at the moment, the sample adding hand dialing 1218 can just dial the reagent card strip 9, the sample adding hand dialing 1218 dials the reagent card strip 9 in the sample adding groove 1107 into a corresponding incubation groove 2501, and then the sample adding hand dialing 1218 and the sample adding groove 1107 return to the initial position respectively. When the incubation time is over, the incubation plate motor 2601 is operated to move the corresponding incubation plate 25, and when the incubation plate 25 reaches the detection position, the incubation device 2 stops moving. Then, the detector motor 35 on the detection device 3 operates to drive the optical detector 37 located right above the detection position to work, and the optical signal scanning is performed on the reagent card strip 9 to read data. After the reading is finished, the card withdrawing and poking motor 4601 operates to drive the card withdrawing and poking hand 45 to directly poke the optically detected reagent card strip 9 from the incubation groove 2501, and the reagent card strip 9 enters the card withdrawing box 15 through the card withdrawing inclined plane 48 to be discarded. The sample to be detected can be added to the reagent card strip by using an automatic sample adding gun, and the automatic sample adding gun can be external corollary equipment of a multi-channel fluorescence immunoassay analyzer and is not shown in the attached drawing.

To sum up, the utility model discloses a multichannel fluorescence immunoassay appearance adopts the integrated design, and compact structure can assay a series of, the large batch sample that awaits measuring fast, and testing result reliability, stability are high, and is fast, and sensitivity is good, both reducible experimenter's operating procedure and work load, can reduce wrong probability again, make the testing result more accurate. The card feeding device 11 includes a card feeding limiting component 1111 disposed at an end close to the sample inlet 1107 and away from the sample inlet, for preventing the reagent card strip 9 from being excessively inserted when inserted into the sample inlet 1107, thereby ensuring the accuracy of the insertion position of the reagent card strip 9. The sample introduction hand shifting assembly in the sample introduction hand shifting device 12 adopts a connection mode of a multi-connection block and sliding block guide rail structure, the transmission structure is stable and reliable, the sample introduction hand shifting device can effectively shift the reagent card strip 9 into the incubation device 2, and the operation stability and the accuracy reliability of the instrument structure are improved. All be equipped with the motion stop device in advancing kind and dialling hand device 12, incubation device 2, detection device 3, move back card device 4, make the instrument operation more accurate, the testing result is more effective reliable.

The above description is only for the preferred embodiment of the present invention and is not intended to limit the present invention, and those skilled in the art can make various changes, modifications, substitutions and alterations without departing from the principle and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A multi-channel fluorescence immunoassay analyzer comprises a workbench and a shell, and is characterized in that the workbench and the shell form an accommodating space; the sample feeding device, the incubation device, the detection device and the card withdrawing device are all arranged in the accommodating space and are respectively arranged on the workbench; the sample introduction device is used for enabling a reagent card strip sample to enter a sample introduction groove, the incubation device is used for incubating the reagent card strip sample, the detection device is used for carrying out optical detection on the incubated reagent card strip sample, and the card withdrawal device is used for poking the detected reagent card strip sample away; wherein the sample introduction device comprises a card inlet device, a sample introduction shifting handle device and a code scanning device, and a sample introduction shifting handle assembly is arranged in the sample introduction shifting handle device.

2. The multi-channel fluorescence immunoassay analyzer of claim 1, wherein the sample injection hand-shifting assembly comprises a second fixed block, a second guide rail, a second slide block, a sample injection hand-shifting arm, a second limit rod, a second limit groove and a sample injection hand-shifting; the second fixed block is connected with the second guide rail, the second sliding block is connected with the sample injection hand knob through the sample injection hand knob arm, the sample injection hand knob arm is connected with the second limiting rod, the second sliding block is connected with the second guide rail in a sliding mode, and the second sliding block, the second limiting rod, the sample injection hand knob arm and the sample injection hand knob move synchronously; the second limiting groove is formed in the workbench and controls the second limiting rod to move.

3. The multi-channel fluoroimmunoassay analyzer of claim 1, wherein the sample hand-shifting device further comprises a sample hand-shifting position-limiting device.

4. The multi-channel fluoroimmunoassay analyzer of claim 1, wherein the detecting device comprises a mounting plate, a detector guide rail, a detector slider, a sixth connecting block, a detector driving device, a detector screw rod and an optical detector, the mounting plate is mounted on the worktable, the detector guide rail is connected to the mounting plate and slidably connected with the detector slider, the detector slider is connected with the optical detector through the sixth connecting block, the detector driving device is mounted on the mounting plate and connected with one end of the detector screw rod and controls the rotation of the detector screw rod, the detector screw rod is in threaded transmission connection with the sixth connecting block, and the mounting surface of the detector guide rail is parallel to the surface of the worktable.

5. The multi-channel fluoroimmunoassay analyzer of claim 4, wherein the detecting means further comprises detector limiting means for limiting movement of the optical detector.

6. The multi-channel fluoroimmunoassay analyzer of claim 1, wherein the incubation device comprises an incubation tray stop.

7. The multi-channel fluoroimmunoassay analyzer of claim 6, wherein the incubation device comprises an incubation tray provided with a pellet.

8. The multi-channel fluorescence immunoassay analyzer of claim 1, wherein the card withdrawing device comprises a card withdrawing and dialing limiting device and a card withdrawing inclined plane, wherein the card withdrawing and dialing limiting device is used for controlling the motion limiting of the card withdrawing and dialing, the card withdrawing inclined plane is installed on the workbench, and the reagent card strip sample slides off through the card withdrawing inclined plane after being dialed away by the card withdrawing and dialing.

9. The multi-channel fluoroimmunoassay analyzer of claim 1, further comprising a printing device and a display device, wherein the display device is configured to display the detection information of the reagent card strip sample, and the printing device is configured to output the detection information of the reagent card strip sample.