CN214473046U - Multidimensional liquid chromatography system - Google Patents
Multidimensional liquid chromatography system Download PDFInfo
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- CN214473046U CN214473046U CN202120591977.0U CN202120591977U CN214473046U CN 214473046 U CN214473046 U CN 214473046U CN 202120591977 U CN202120591977 U CN 202120591977U CN 214473046 U CN214473046 U CN 214473046U
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- 238000004811 liquid chromatography Methods 0.000 title claims abstract description 18
- 239000007788 liquid Substances 0.000 claims abstract description 52
- 239000002699 waste material Substances 0.000 claims abstract description 47
- 238000004458 analytical method Methods 0.000 claims abstract description 14
- 238000004587 chromatography analysis Methods 0.000 claims description 22
- 238000002414 normal-phase solid-phase extraction Methods 0.000 claims description 7
- 238000000926 separation method Methods 0.000 claims description 5
- 239000012071 phase Substances 0.000 claims description 3
- 230000002457 bidirectional effect Effects 0.000 claims description 2
- 238000004885 tandem mass spectrometry Methods 0.000 claims description 2
- 239000000523 sample Substances 0.000 description 28
- 238000001514 detection method Methods 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 4
- 239000003085 diluting agent Substances 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 3
- 238000010494 dissociation reaction Methods 0.000 description 3
- 230000005593 dissociations Effects 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 238000001819 mass spectrum Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
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Abstract
The utility model discloses a multidimensional liquid chromatography system, including the first chromatographic pump that is used for carrying the releasing agent, the second chromatographic pump that is used for carrying the mobile phase, first waste liquid pipeline and analysis pipeline, the liquid outlet of first chromatographic pump is connected with the sample injector, still includes three first multi-way valve, second multi-way valve and the third multi-way valve that are used for connecting and switching each pipeline through the pipeline series connection, all be connected with the chromatographic column between the arbitrary both ends mouth of each first multi-way valve, second multi-way valve and third multi-way valve; the sample injector connected with the first chromatographic pump and the second chromatographic pump are respectively connected with one port of the first multi-way valve, the second waste liquid pipeline is connected with one port of the second multi-way valve, and the analysis pipeline is connected with one port of the third multi-way valve. The utility model discloses can select dimension and self-bleeding multidimensional liquid chromatograph in a flexible way.
Description
Technical Field
The utility model relates to a liquid chromatogram field, in particular to multi-dimensional liquid chromatogram system.
Background
Since macromolecular impurities such as protein contained in the biological sample easily interfere the detection of small molecular compounds and easily cause pipeline blockage and different degrees of deterioration of the first-dimension chromatographic column, the problems can be solved by adopting a multi-dimension liquid chromatography technology. The multidimensional liquid chromatography technology firstly removes protein and other macromolecular impurities through on-line solid phase extraction, enriches small molecular compounds to increase peak capacity, thereby effectively improving the separation degree and peak type of the separation of small molecular compounds in complex samples and improving the sensitivity of the complex samples. However, the existing liquid chromatography technology cannot directly enter a large-volume plasma/serum sample, is not flexible in arrangement, and cannot carry out detection according to the biological characteristics, impurity conditions and the like of a detection sample. And when the existing chromatographic pump is in an exhaust mode, the exhaust valve of the chromatographic pump is manually started to automatically remove air bubbles in the detected sample.
Disclosure of Invention
The utility model aims at providing a dimension can be selected in a flexible way, self-bleeding multidimensional liquid chromatography system to the not enough of prior art.
The technical scheme of the utility model is that:
a multi-dimensional liquid chromatography system comprises a first chromatography pump for conveying a releasing agent, a second chromatography pump for conveying a mobile phase, a first waste liquid pipeline and an analysis pipeline, wherein a liquid outlet of the first chromatography pump is connected with a sample injector, the first waste liquid pipeline is connected with a first waste liquid pool, the analysis pipeline is connected with a detector, the multi-dimensional liquid chromatography system further comprises three chromatography columns, a first multi-way valve, a second multi-way valve and a third multi-way valve, the first multi-way valve, the second multi-way valve and the third multi-way valve are connected in series through pipelines and used for connecting and switching the pipelines, the three chromatography columns are respectively a first chromatography column, a second chromatography column and a third chromatography column, the first chromatography column is arranged on the first multi-way valve, and is an online solid phase extraction column for bidirectional separation; the second chromatographic column is arranged on the second multi-way valve and is an online analytical column or an online solid-phase extraction column; the third chromatographic column is arranged on the third multi-way valve and is an online analysis column; the sample injector of the first chromatographic pump and the second chromatographic pump are respectively connected with one port of the first multi-way valve, the first waste liquid pipeline is connected with one port of the second multi-way valve, and the analysis pipeline is connected with one port of the third multi-way valve.
Furthermore, the first multi-way valve and the second multi-way valve are both two-position six-way valves, a first chromatographic column is connected between a first port and a fourth port of the first multi-way valve, a second port is connected with a sixth port of the second multi-way valve, a third port is connected with the second chromatographic pump, a fifth port is connected with a second port of the second multi-way valve, and the sixth port is connected with a sample injector of the first chromatographic pump; a second chromatographic column is connected between the first port and the fourth port of the second multi-way valve, the third port is connected with a first waste liquid pool through a first waste liquid pipeline, and the fifth port is connected with the sixth port of the third multi-way valve; and a third chromatographic column is connected between the first port and the fourth port of the third multi-way valve.
Furthermore, a sixth port of the first multi-way valve is connected with a second port of the second multi-way valve, and a fifth port of the first multi-way valve is connected with a sample injector of the first chromatographic pump.
Further, the third multi-way valve is a four-way valve or a two-position six-way valve.
Furthermore, still be equipped with the flow divider between first chromatographic pump with the injector, be connected with a bypass pipeline on the flow divider, the bypass pipeline pass through the tee bend with the export of injector links to each other.
Further, still include the third chromatography pump that is used for carrying the release agent, the third chromatography pump is connected through the three-way valve the injector of first chromatography pump links to each other, and the third chromatography pump is binary pump, quaternary pump, or single pump.
The device comprises a first waste liquid pipeline, a second waste liquid pipeline, a first chromatographic column, a second chromatographic pump, a third chromatographic pump, a fifth chromatographic pump, a sixth chromatographic pump, a sample injector, a fifth chromatographic pump, a sixth chromatographic pump, a seventh waste liquid pipeline, a third chromatographic pump, a fourth chromatographic column, a third chromatographic pump, a fourth chromatographic column, a third chromatographic column, a fourth chromatographic column, a third chromatographic pump, a fourth chromatographic column, a third chromatographic pump, a fourth chromatographic pump, a fifth chromatographic pump, a sixth chromatographic pump, a seventh waste liquid pipeline, a third chromatographic column, a fourth chromatographic column, a fifth chromatographic pump, a sample injector, a sixth chromatographic pump, a seventh waste liquid pipeline and a second waste liquid pipeline; the second chromatographic column is connected between the first port and the fourth port of the second multi-way valve, the third port is connected with the first waste liquid pool through the first waste liquid pipeline, and the fifth port is connected with the third multi-way valve; and a third chromatographic column is connected between the first port and the fourth port of the third multi-way valve.
Furthermore, a fifth port of the first multi-way valve is connected with a second port of the second multi-way valve, and a sixth port of the first multi-way valve is connected with a sample injector of the first chromatographic pump.
Further, the first chromatographic pump and the second chromatographic pump are binary pumps, quaternary pumps or single pumps.
Further, the detector is an ultraviolet detector, a diode array detector, a single-pole mass spectrometer or a triple quadrupole mass spectrometer detector.
Adopt above-mentioned technical scheme to have following beneficial effect:
the utility model discloses a first multi-way valve, second multi-way valve and the third multi-way valve that are used for connecting and switch each pipeline of three series connection, the quantity through each chromatographic column can be adjusted in a flexible way in the switching of control multi-way valve, and second chromatographic column, third chromatographic column can detect alone to realize the chromatogram of different dimensions and detect, and can realize the independent quick self-bleeding of each pump.
A shunt valve is arranged between the outlet of the first chromatographic pump and the inlet of the sample injector, a bypass pipeline is connected to the shunt valve, and the bypass pipeline is connected with the outlet of the sample injector through a tee joint. The bypass pipeline is additionally arranged, so that the online protein dissociation of the sample in the sample injector can be carried out.
The third chromatogram pump passes through the three-way valve and links to each other with the injector of first chromatogram pump, carries out online protein dissociation to the sample in the injector through the third chromatogram pump, and the volume of diluent not only can be adjusted as required to the third chromatogram pump, can also adopt different diluents, is suitable for more detection items.
Still include the second waste liquid pipeline, the second waste liquid pipeline is connected with the second waste liquid pond, first multi-way valve adopts three-position seven to lead the valve, can realize that each pump exhausts simultaneously through increasing the second waste liquid pipeline, has saved operating time.
The following description is further described in conjunction with the accompanying drawings and the detailed description.
Drawings
Fig. 1 is a schematic structural diagram of specific embodiment 1:
FIG. 2 is a schematic structural view of embodiment 2;
FIG. 3 is a schematic structural view of embodiment 3;
fig. 4 is a schematic structural diagram of embodiment 4.
In the drawing, a first multi-way valve a, a second multi-way valve B, a third multi-way valve C, a detector D, a first chromatographic pump P1, a second chromatographic pump P2, a third chromatographic pump P3, a sample injector SIL, a first chromatographic column C1, a second chromatographic column C2, a third chromatographic column C3, a connecting pipeline S, a flow dividing valve F, a three-way valve Y, a first waste liquid pool V1, and a second waste liquid pool V2.
Detailed Description
Specific example 1:
referring to fig. 1, a multi-dimensional liquid chromatograph includes a first chromatographic pump P1 for delivering a releasing agent, a second chromatographic pump P2 for delivering a mobile phase, a first waste liquid pipeline, an analysis pipeline, three chromatographic columns, and three first, second, and third multi-way valves a, B, and C connected in series through pipelines for connecting and switching the pipelines, wherein a liquid outlet of the first chromatographic pump P1 is connected with a sample injector SIL which may adopt a manual sample injector valve, an autosampler SIL, and a pre-treatment instrument. And a detector D is arranged on the analysis pipeline, and the detector D is an ultraviolet detector UV, a diode array detector DAD, a single-pole mass spectrum MS or a triple quadrupole mass spectrum detector MS/MS and the like. The first chromatographic pump P1 and the second chromatographic pump P2 are binary pumps, quaternary pumps or single pumps. Three chromatographic columns are first chromatographic column C1, second chromatographic column C2, third chromatographic column C3 respectively, first chromatographic column C1 corresponds and connects on first multi-way valve A, and this first chromatographic column C1 is the online solid phase extraction column that can carry out two-way separation, second chromatographic column C2 corresponds and connects on second multi-way valve B, second chromatographic column C2 is online analytical column or online solid phase extraction column, and third chromatographic column C3 corresponds and connects on third multi-way valve C, and third chromatographic column C3 is online analytical column. The sample injector of the first chromatographic pump and the second chromatographic pump are respectively connected with one port of the first multi-way valve A, the first waste liquid pipeline is connected with one port of the second multi-way valve B, and the analysis pipeline is connected with one port of the third multi-way valve C.
In this particular embodiment: the first multi-way valve A, the second multi-way valve B and the third multi-way valve C are two-position six-way valves, a first port and a fourth port of the first multi-way valve A are connected with a first chromatographic column C1, a second port is connected with a sixth port of the second multi-way valve B, a third port is connected with a second chromatographic pump P2, a fifth port is connected with a second port of the second multi-way valve B, and the sixth port is connected with an SIL sample injector of the first chromatographic pump. And a first port and a fourth port of the second multi-way valve B are connected with a second chromatographic column C2, a third port is connected with a first waste liquid pool V1 through a first waste liquid pipeline, and a fifth port is connected with a sixth port of the third multi-way valve C. And a first port and a fourth port of the third multi-way valve C are connected with a third chromatographic column C3, a connecting pipeline S is connected between the second port and the third port, and a fifth port is connected with a detector D of the analysis pipeline.
Possibly, the sixth port of the first multi-way valve a is connected to the second port of said second multi-way valve B and the fifth port of the first multi-way valve a is connected to the injector SIL of the first chromatographic pump P1.
The utility model discloses can switch A, B, C three multi-ported valve's port hookup location adjustment multidimension liquid chromatograph's dimension in a flexible way as required, second chromatographic column C2, third chromatographic column C3 all can detect alone to realize the interests maximize.
Specific example 2:
referring to fig. 2, the present embodiment is characterized in that: a shunt valve F is arranged between the outlet of the first chromatographic pump P1 and the inlet of the sample injector SIL, the shunt valve F adopts a one-in two-out (or one-in three-out) structure and can adjust the flow rate of each outlet, a bypass pipeline is connected to the shunt valve F, the bypass pipeline is connected to the outlet of the sample injector SIL through a tee joint, and the sample in the sample injector can be diluted on line by adding the bypass pipeline. Other features are the same as those of embodiment 1, and thus this embodiment is omitted here.
Specific example 3:
referring to fig. 3, the present embodiment is characterized in that: the device also comprises a third chromatographic pump P3 for conveying releasing agents, wherein the third chromatographic pump P3 is connected with the sample injector of the first chromatographic pump through a three-way valve Y, and the third chromatographic pump P3 is a binary pump, a quaternary pump or a single pump. The third chromatographic pump P3 is used for on-line protein dissociation of the sample in the sample injector, so that the amount of the diluent can be adjusted, different diluents can be adopted, and the method is suitable for more detection items. Other features are the same as those of embodiment 1, and thus this embodiment is omitted here.
Specific example 4:
referring to fig. 4, the present embodiment is characterized in that: the waste liquid treatment device further comprises a second waste liquid pipeline, the second waste liquid pipeline is connected with a second waste liquid pool V2, the first multi-way valve A adopts a three-position seven-way valve, and the second multi-way valve B and the third multi-way valve C are two-position six-way valves.
In this particular embodiment: the first multi-way valve A is provided with seven ports, a first port and a fourth port of the first multi-way valve A are connected with a first chromatographic column C1, a second port is connected with a second chromatographic pump P2, a third port is connected with a sixth port of the second multi-way valve B, a fifth port is connected with a sample injector SIL of the first chromatographic pump P1, the sixth port is connected with a second port of the second multi-way valve B, and a seventh port is connected with a second waste liquid pool V2 through a second waste liquid pipeline. And a first port and a fourth port of the second multi-way valve B are connected with a second chromatographic column C2, a third port is connected with a first waste liquid pool V1 through a first waste liquid pipeline, and a fifth port is connected with a sixth port of the third multi-way valve C. And a first port and a fourth port of the third multi-way valve C are connected with a third chromatographic column C3, a fifth port is connected with a detector D of the analysis pipeline, and a connecting pipeline is connected between the second port and the third port. Possibly, the fifth port of the first multi-way valve a is connected to the second port of said second multi-way valve B and the sixth port is connected to the injector SIL of the first chromatographic pump P1. Other features are the same as those of embodiment 1, embodiment 2 or embodiment 3, and thus this embodiment is omitted here. The utility model discloses a first chromatography pump P1 and the automatic exhaust simultaneously of second chromatography pump P2 have been realized to first, second waste liquid pipeline, have shortened operating time.
Claims (9)
1. A multidimensional liquid chromatography system comprising a first chromatography pump (P1) for delivering a releasing agent, a second chromatography pump (P2) for delivering a mobile phase, a first waste line and an analysis line, the outlet of the first chromatography pump being connected to a Sample Injector (SIL), the first waste line being connected to a first waste reservoir (V1), the analysis line being connected to a detector (D), characterized in that: the device comprises a first multi-way valve (A), a second multi-way valve (B) and a third multi-way valve (C), wherein the first multi-way valve (A), the second multi-way valve (B) and the third multi-way valve (C) are connected in series through pipelines and are used for connecting and switching pipelines, the three chromatographic columns are respectively a first chromatographic column (C1), a second chromatographic column (C2) and a third chromatographic column (C3), the first chromatographic column (C1) is arranged on the first multi-way valve (A), and the first chromatographic column (C1) is an online solid-phase extraction column for bidirectional separation; the second chromatographic column (C2) is arranged on the second multi-way valve (B), and the second chromatographic column (C2) is an online analytical column or an online solid-phase extraction column; the third chromatography column (C3) is disposed on the third multi-way valve (C), the third chromatography column (C3) being an on-line analytical column; the sample injector of the first chromatographic pump (P1) and the second chromatographic pump (P2) are respectively connected with one port of the first multi-way valve (A), the first waste liquid pipeline is connected with one port of the second multi-way valve (B), and the analysis pipeline is connected with one port of the third multi-way valve (C).
2. The multi-dimensional liquid chromatography system of claim 1, wherein: the first multi-way valve (A) and the second multi-way valve (B) are both two-position six-way valves, the third multi-way valve (C) is a four-way valve or a two-position six-way valve, a first chromatographic column (C1) is connected between a first port and a fourth port of the first multi-way valve (A), a second port is connected with a sixth port of the second multi-way valve (B), a third port is connected with the second chromatographic pump (P2), a fifth port is connected with a second port of the second multi-way valve (B), and the sixth port is connected with a Sample Injector (SIL) of the first chromatographic pump (P1); a second chromatographic column (C2) is connected between the first port and the fourth port of the second multi-way valve (B), the third port is connected with a first waste liquid pool (V1) through a first waste liquid pipeline, and the fifth port is connected with the sixth port of the third multi-way valve (C); and a third chromatographic column (C3) is connected between the first port and the fourth port of the third multi-way valve (C).
3. The multi-dimensional liquid chromatography system of claim 2, wherein: the sixth port of the first multi-way valve (A) is connected with the second port of the second multi-way valve (B), and the fifth port of the first multi-way valve (A) is connected with the Sample Injector (SIL) of the first chromatographic pump (P1).
4. The multi-dimensional liquid chromatography system of claim 1, wherein: a shunt valve (F) is further arranged between the first chromatographic pump (P1) and the Sample Injector (SIL), a bypass pipeline is connected to the shunt valve (F), and the bypass pipeline is connected with an outlet of the Sample Injector (SIL) through a tee joint.
5. The multi-dimensional liquid chromatography system of claim 1, wherein: the device also comprises a third chromatographic pump (P3) for delivering releasing agents, wherein the third chromatographic pump (P3) is connected with a sample injector of the first chromatographic pump through a three-way valve (Y), and the third chromatographic pump (P3) is a binary pump, a quaternary pump or a single pump.
6. The multi-dimensional liquid chromatography system of claim 1, 4 or 5, wherein: the device is characterized by further comprising a second waste liquid pipeline, wherein the second waste liquid pipeline is connected with a second waste liquid pool (V2), the first multi-way valve (A) adopts a three-position seven-way valve, the second multi-way valve (B) adopts a two-position six-way valve, a first port and a fourth port of the first multi-way valve (A) are connected with the first chromatographic column (C1), a second port is connected with the second chromatographic pump (P2), a third port is connected with a sixth port of the second multi-way valve (B), a fifth port is connected with a Sample Injector (SIL) of the first chromatographic pump (P1), the sixth port is connected with a second port of the second multi-way valve (B), and a seventh port is connected with the second waste liquid pipeline; the first port and the fourth port of the second multi-way valve (B) are connected with the second chromatographic column (C2), the third port is connected with a first waste liquid pool (V1) through the first waste liquid pipeline, and the fifth port is connected with the third multi-way valve (C); and a third chromatographic column (C3) is connected between the first port and the fourth port of the third multi-way valve (C).
7. The multi-dimensional liquid chromatography system of claim 6, wherein: the fifth port of the first multi-way valve (A) is connected with the second port of the second multi-way valve (B), and the sixth port is connected with the Sample Injector (SIL) of the first chromatographic pump (P1).
8. The multi-dimensional liquid chromatography system of claim 1, wherein: the first chromatography pump (P1) and the second chromatography pump (P2) are binary pumps, quaternary pumps, or single pumps.
9. The multi-dimensional liquid chromatography system of claim 1, wherein: the detector (D) is an ultraviolet detector (UV), a Diode Array Detector (DAD), a single-pole Mass Spectrometer (MS) or a triple quadrupole mass spectrometer (MS/MS).
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120591977.0U CN214473046U (en) | 2021-03-23 | 2021-03-23 | Multidimensional liquid chromatography system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202120591977.0U CN214473046U (en) | 2021-03-23 | 2021-03-23 | Multidimensional liquid chromatography system |
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| CN214473046U true CN214473046U (en) | 2021-10-22 |
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| CN202120591977.0U Active CN214473046U (en) | 2021-03-23 | 2021-03-23 | Multidimensional liquid chromatography system |
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| CN (1) | CN214473046U (en) |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Multidimensional Liquid Chromatography System Effective date of registration: 20220922 Granted publication date: 20211022 Pledgee: Bank of Suzhou Co.,Ltd. Shishan road sub branch Pledgor: Suzhou aidimai Medical Technology Co.,Ltd. Registration number: Y2022320010536 |
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| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Granted publication date: 20211022 Pledgee: Bank of Suzhou Co.,Ltd. Shishan road sub branch Pledgor: Suzhou aidimai Medical Technology Co.,Ltd. Registration number: Y2022320010536 |