CN215066381U - Multidimensional liquid chromatograph with three pumps and three valves - Google Patents
Multidimensional liquid chromatograph with three pumps and three valves Download PDFInfo
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- CN215066381U CN215066381U CN202120591868.9U CN202120591868U CN215066381U CN 215066381 U CN215066381 U CN 215066381U CN 202120591868 U CN202120591868 U CN 202120591868U CN 215066381 U CN215066381 U CN 215066381U
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Abstract
The utility model discloses a three-pump three-valve multidimensional liquid chromatograph, including a first chromatographic pump, a second chromatographic pump, a third chromatographic pump, a first waste liquid flow channel and an analysis flow channel, wherein the liquid outlet of the first chromatographic pump is connected with a sample injector, the three-pump three-valve multidimensional liquid chromatograph further comprises a second waste liquid flow channel and three first multi-way valves, second multi-way valves and third multi-way valves which are connected in series through pipelines and used for connecting and switching the flow channels, the second waste liquid flow channel is connected with a second waste liquid pool, and chromatographic columns are connected between any two ports of the first multi-way valves, the second multi-way valves and the third multi-way valves; the sample injector connected with the first chromatographic pump and the second chromatographic pump are respectively connected with one port of the first multi-way valve, the second waste liquid flow channel is connected with one port of the second multi-way valve, and the analysis flow channel, the third chromatographic pump and the second waste liquid flow channel are respectively connected with one port of the third multi-way valve. The utility model discloses can improve work efficiency and self-bleeding's multidimensional liquid chromatograph.
Description
Technical Field
The utility model relates to a liquid chromatogram field, in particular to multidimensional liquid chromatograph of three pumps three valves.
Background
Since macromolecular impurities such as protein contained in the biological sample easily interfere the detection of small molecular compounds and easily cause pipeline blockage and different degrees of deterioration of the first-dimension chromatographic column, the problems can be solved by adopting a multi-dimension liquid chromatography technology. The multidimensional liquid chromatography technology firstly removes protein and other macromolecular impurities through on-line solid phase extraction, enriches small molecular compounds to increase peak capacity, thereby effectively improving the separation degree and peak type of the separation of small molecular compounds in complex samples and improving the sensitivity of the complex samples. However, the existing two-dimensional liquid chromatography technology cannot directly enter large-volume plasma/serum samples, and the working efficiency of single detection is low. And when the existing chromatographic pump is in an exhaust mode, the exhaust valve of the chromatographic pump is manually started to automatically remove air bubbles in the detected sample.
Disclosure of Invention
The utility model aims at providing a can improve work efficiency and self-bleeding's three pumps three valves's multidimensional liquid chromatograph to prior art's not enough.
The technical scheme of the utility model is that:
a multidimensional liquid chromatograph with three pumps and three valves comprises a first chromatographic pump, a second chromatographic pump, a third chromatographic pump, a first waste liquid flow channel and an analysis flow channel, wherein a liquid outlet of the first chromatographic pump is connected with a sample injector, the first waste liquid flow channel is connected with a first waste liquid pool, the analysis flow channel is provided with a detector, the multidimensional liquid chromatograph further comprises a second waste liquid flow channel, and three first multi-way valves, second multi-way valves and third multi-way valves which are connected in series through pipelines and used for connecting and switching the flow channels, the second waste liquid flow channel is connected with a second waste liquid pool, and chromatographic columns are connected among any two ports of the first multi-way valves, the second multi-way valves and the third multi-way valves; the sample injector connected with the first chromatographic pump and the second chromatographic pump are respectively connected with one port of the first multi-way valve, the first waste liquid flow channel is connected with one port of the second multi-way valve, and the analysis flow channel, the third chromatographic pump and the second waste liquid flow channel are respectively connected with one port of the third multi-way valve.
Furthermore, a shunt valve is further arranged between the first chromatographic pump and the sample injector, a bypass flow channel is connected to the shunt valve, and the bypass flow channel is connected with an outlet of the sample injector through a tee joint.
Furthermore, the chromatographic columns are respectively a first chromatographic column, a second chromatographic column and a third chromatographic column, the first chromatographic column is arranged on the first multi-way valve, and the first chromatographic column is an online solid-phase extraction column for bidirectional separation; the second chromatographic column is arranged on the second multi-way valve and is an online analytical column or an online solid-phase extraction column; the third chromatographic column is arranged on the third multi-way valve and is an online analysis column.
The first multi-way valve, the second multi-way valve and the third multi-way valve are all two-position six-way valves, a first color spectrum column is connected between a first port and a fourth port of the first multi-way valve, a second port of the first multi-way valve is connected with a sixth port of the second multi-way valve, a third port of the first multi-way valve is connected with a second color spectrum pump, a fifth port of the first multi-way valve is connected with a second port of the second multi-way valve, and a sixth port of the first multi-way valve is connected with a sample injector of the first color spectrum pump; a second chromatographic column is connected between a first port and a fourth port of the second multi-way valve, a third port of the second multi-way valve is connected with a first waste liquid pool through a first waste liquid flow channel, and a fifth port of the second multi-way valve is connected with a third multi-way valve; and a third chromatographic column is connected between the first port and the fourth port of the third multi-way valve, the second port of the third multi-way valve is connected with the third chromatographic pump, the third port of the third multi-way valve is connected with the analysis flow channel, and the fifth port of the third multi-way valve is connected with a second waste liquid pool through a second waste liquid flow channel.
Furthermore, a sixth port of the first multi-way valve is connected with a second port of the second multi-way valve, and a fifth port of the first multi-way valve is connected with a sample injector of the first chromatographic pump.
The third waste liquid channel is connected with a third waste liquid pool, the first multi-way valve adopts a three-position seven-way valve, the second multi-way valve adopts a two-position six-way valve, the first chromatographic column is connected between a first port and a fourth port of the first multi-way valve, a second port of the first multi-way valve is connected with the second chromatographic pump, a third port of the first multi-way valve is connected with a sixth port of the second multi-way valve, a fifth port of the first multi-way valve is connected with a sample injector of the first chromatographic pump, the sixth port of the first multi-way valve is connected with a second port of the second multi-way valve, and the seventh port of the first multi-way valve is connected with the third waste liquid pool through the third waste liquid channel; the first port and the fourth port of the second multi-way valve are connected with the second chromatographic column, the third port of the second multi-way valve is connected with the first waste liquid pool through the first waste liquid flow channel, and the fifth port of the second multi-way valve is connected with the sixth port of the third multi-way valve; and a third chromatographic column is connected between the first port and the fourth port of the third multi-way valve, the second port of the third multi-way valve is connected with the third chromatographic pump, the third port of the third multi-way valve is connected with the analysis flow channel, and the fifth port of the third multi-way valve is connected with a second waste liquid pool through a second waste liquid flow channel.
Furthermore, a sixth port of the first multi-way valve is connected with a sample injector of the first chromatographic pump, and a fifth port of the first multi-way valve is connected with a second port of the second multi-way valve.
Furthermore, a three-way valve is arranged on each of the analysis flow channel and the second waste liquid flow channel, and a drainage pipeline is connected between the analysis flow channel and the second waste liquid flow channel through the three-way valve.
Further, the first chromatography pump, the second chromatography pump and the third chromatography pump are binary pumps, quaternary pumps or single pumps.
Furthermore, the analysis runner is provided with a detector, and the detector is an ultraviolet detector, a diode array detector, a single-pole mass spectrometer or a triple quadrupole mass spectrometer.
Adopt above-mentioned technical scheme to have following beneficial effect:
the utility model adopts three first, second and third multi-way valves which are connected in series and used for connecting and switching each flow passage, and chromatographic columns are connected between any two ports of the first, second and third multi-way valves; the double-column detection can be realized by controlling the switching of the multi-way valve, so that the detection time of each sample can be prolonged to 8 min. The first waste liquid pool and the second waste liquid pool realize independent, rapid and automatic exhaust of each pump. The third chromatogram pump sets up at the third multi-way valve, carries out online protein dissociation through the sample of third chromatogram pump in to the injector, and the volume of diluent not only can be adjusted as required to the third chromatogram pump, can also adopt different diluents, is suitable for more detection items.
A shunt valve is arranged between the outlet of the first chromatographic pump and the inlet of the sample injector, a bypass flow channel is connected to the shunt valve, and the bypass flow channel is connected with the outlet of the sample injector through a tee joint. The bypass flow channel is added to perform online protein dissociation on the sample in the sample injector.
The three-position seven-way valve is adopted as the first multi-way valve, and the three-position seven-way valve is added to realize simultaneous air exhaust of the chromatographic pumps, so that the operation time is saved.
The analysis flow channel and the second waste liquid flow channel are both provided with a three-way valve, and a drainage pipeline is connected between the analysis flow channel and the second waste liquid flow channel through the three-way valve. The second or third chromatographic column may be passed through a detector, which may be in single column mode.
The following description is further described in conjunction with the accompanying drawings and the detailed description.
Drawings
Fig. 1 is a schematic structural diagram of specific embodiment 1:
FIG. 2 is a schematic structural view of embodiment 2;
FIG. 3 is a schematic structural view of embodiment 3;
fig. 4 is a schematic structural diagram of embodiment 4.
In the drawing, a first multi-way valve a, a second multi-way valve B, a third multi-way valve C, a detector D, a first chromatographic pump P1, a second chromatographic pump P2, a third chromatographic pump P3, a sample injector SIL, a first chromatographic column C1, a second chromatographic column C2, a third chromatographic column C3, a flow dividing valve F, a first waste liquid pool V1, a second waste liquid pool V2, and a third waste liquid pool V3.
Detailed Description
Specific example 1:
referring to fig. 1, a three-pump three-valve multi-dimensional liquid chromatograph includes a first chromatographic pump P1 for delivering a releasing agent, a third chromatographic pump P3, a second chromatographic pump P2 for delivering a mobile phase, a first waste liquid channel, a second waste liquid channel, an analysis channel, and three first, second, and third multi-way valves a, B, and C connected in series by pipes for connecting and switching the respective channels, wherein the first chromatographic pump P1 is used for delivering a releasing agent for a first chromatographic column C1 on-line extraction column, the second chromatographic pump P2 is used for delivering a mobile phase to a second chromatographic column C2 and a third chromatographic column C3, and the third chromatographic pump P3 is used for delivering an additional releasing agent for on-line dissociation of protein. The liquid outlet of the first chromatographic pump P1 is connected with a sample injector SIL, which can adopt a manual sample injection valve, an autosampler SIL, and a pretreatment instrument. The analysis flow channel is provided with a detector D, the detector D can be provided with a detector D through the analysis flow channel, and the detector D is an ultraviolet detector UV, a diode array detector DAD, a single-pole mass spectrum MS or a triple quadrupole mass spectrum detector MS/MS and the like. The first waste liquid channel is connected with a first waste liquid pool V1, the second waste liquid channel is connected with a second waste liquid pool V2, and the first chromatographic pump P1 and the second chromatographic pump P2 are binary pumps, quaternary pumps or single pumps. Chromatographic columns can be connected among any two ports of the first multi-way valve A, the second multi-way valve B and the third multi-way valve C, namely a first chromatographic column C1, a second chromatographic column C2 and a third chromatographic column C3 respectively, the first chromatographic column C1 is correspondingly connected to the first multi-way valve A, the first chromatographic column C1 is an online solid-phase extraction column capable of performing bidirectional separation, the second chromatographic column C2 is correspondingly connected to the second multi-way valve B, the second chromatographic column C2 is an online analytical column or an online solid-phase extraction column, the third chromatographic column C3 is correspondingly connected to the third multi-way valve C, and the third chromatographic column C3 is an online analytical column. The sample injector of the first chromatographic pump P1 and the second chromatographic pump P2 are respectively connected with one port of the first multi-way valve A, the first waste liquid flow channel is connected with one port of the second multi-way valve B, and the analysis flow channel, the third chromatographic pump P3 and the second waste liquid flow channel are respectively connected with one port of the third multi-way valve C.
In this particular embodiment: the first multi-way valve A, the second multi-way valve B and the third multi-way valve C are two-position six-way valves, a first port and a fourth port of the first multi-way valve A are connected with a first chromatographic column C1, a second port of the first multi-way valve A is connected with a sixth port of the second multi-way valve B, a third port of the first multi-way valve A is connected with a second chromatographic pump P2, a fifth port of the first multi-way valve A is connected with a second port of the second multi-way valve B, and a sixth port of the first multi-way valve A is connected with a sample injector SIL of the first chromatographic pump. And a first port and a fourth port of the second multi-way valve B are connected with a second chromatographic column C2, a third port of the second multi-way valve B is connected with a first waste liquid pool V1 through a first waste liquid flow channel, and a fifth port of the second multi-way valve B is connected with a sixth port of the third multi-way valve C. And a first port and a fourth port of the third multi-way valve C are connected with a third chromatographic column C3, a second port of the third multi-way valve C is connected with the third chromatographic pump P3, a third port of the third multi-way valve C is connected with the detector D of the analysis flow channel, and a fifth port of the third multi-way valve C is connected with a second waste liquid pool V2 through a second waste liquid flow channel.
Possibly, the sixth port of the first multi-way valve a is connected to the second port of said second multi-way valve B and the fifth port of the first multi-way valve a is connected to the injector SIL of the first chromatographic pump P1.
The utility model discloses can switch A, B, C three multi-ported valve's port hookup location adjustment multidimension liquid chromatograph's dimension in a flexible way as required, second chromatographic column C2, third chromatographic column C3 all can detect alone to realize the interests maximize. When the first sample is in the analytical column, the next sample can enter the extraction at this time, which is equivalent to starting the next detection without waiting for the first detection to be completed, thereby improving the working efficiency.
Specific example 2:
referring to fig. 2, the present embodiment is characterized in that: a shunt valve F is arranged between the outlet of the first chromatographic pump P1 and the inlet of the sample injector SIL, the shunt valve F adopts a one-in two-out (or one-in three-out) structure and can adjust the flow rate of each outlet, a bypass flow channel is connected to the shunt valve F, the bypass flow channel is connected to the outlet of the sample injector SIL through a tee joint, and the bypass flow channel is additionally arranged to dilute the sample in the sample injector on line. Other features are the same as those of embodiment 1, and thus this embodiment is omitted here.
Specific example 3:
referring to fig. 3, the present embodiment is characterized in that: the three-position seven-way valve is characterized by further comprising a third waste liquid flow channel, wherein the third waste liquid flow channel is connected with a third waste liquid pool V3, the first multi-way valve A is a three-position seven-way valve, and the second multi-way valve B and the third multi-way valve C are two-position six-way valves.
In this particular embodiment: the first multi-way valve A is provided with seven ports, a first port and a fourth port of the first multi-way valve A are connected with a first chromatographic column C1, a second port of the first multi-way valve A is connected with a second chromatographic pump P2, a third port of the first multi-way valve A is connected with a sixth port of a second multi-way valve B, a fifth port of the first multi-way valve A is connected with a sample injector SIL of the first chromatographic pump P1, a sixth port of the first multi-way valve A is connected with a second port of the second multi-way valve B, and a seventh port of the first multi-way valve A is connected with a third waste liquid pool V3 through a third waste liquid flow channel. And a first port and a fourth port of the second multi-way valve B are connected with a second chromatographic column C2, a third port of the second multi-way valve B is connected with a first waste liquid pool V1 through a first waste liquid flow channel, and a fifth port of the second multi-way valve B is connected with a sixth port of the third multi-way valve C. The first port and the fourth port of the third multi-way valve C are connected with a third chromatographic column C3, a third chromatographic column C3 is connected between the first port and the fourth port of the third multi-way valve C, the second port of the third multi-way valve C is connected with a third chromatographic pump P3, the third port of the third multi-way valve C is connected with a detector D of the analysis flow channel, and the fifth port of the third multi-way valve C is connected with a second waste liquid pool V2 through a second waste liquid flow channel.
Possibly, the fifth port of the first multi-way valve a is connected to the second port of the second multi-way valve B and the sixth port of the first multi-way valve a is connected to the sample injector SIL of the first chromatographic pump P1. Other features are the same as those of embodiment 1 or embodiment 2, and thus this embodiment is omitted here.
The utility model discloses a first waste liquid pond, second waste liquid pond, third waste liquid pond have realized that first chromatography pump P1, second chromatography pump P2 and third chromatography pump P3 are automatic to be exhausted simultaneously, have shortened operating time.
Specific example 4:
referring to fig. 4, the present embodiment is characterized in that: the analysis flow channel and the second waste liquid flow channel are both provided with a three-way valve, and a drainage pipeline is connected between the analysis flow channel and the second waste liquid flow channel through the three-way valve. The second or third chromatographic column may be passed through a detector, which may be in single column mode. Other features are the same as those of embodiment 1, embodiment 2, or embodiment 3, and thus this embodiment is omitted here. The utility model discloses a tee bend links to each other detector and second waste liquid runner, has realized the independent detection of second chromatographic column or third chromatographic column.
Claims (10)
1. The utility model provides a multidimensional liquid chromatograph of three pumps triple valve, includes first chromatogram pump (P1), second chromatogram pump (P2), third chromatogram pump (P3), first waste liquid runner and analysis runner, the liquid outlet of first chromatogram pump is connected with injector (SIL), and first waste liquid runner is connected with first waste liquid pond (V1), the analysis runner is equipped with detector (D), its characterized in that: the device also comprises a second waste liquid flow channel, and a first multi-way valve (A), a second multi-way valve (B) and a third multi-way valve (C) which are connected in series through pipelines and used for connecting and switching the flow channels, wherein the second waste liquid flow channel is connected with a second waste liquid pool (V2), and chromatographic columns are connected among any two ports of the first multi-way valve (A), the second multi-way valve (B) and the third multi-way valve (C); the sample injector connected with the first chromatographic pump and the second chromatographic pump are respectively connected with one port of the first multi-way valve (A), the first waste liquid flow channel is connected with one port of the second multi-way valve (B), and the analysis flow channel, the third chromatographic pump (P3) and the second waste liquid flow channel are respectively connected with one port of the third multi-way valve (C).
2. A three-pump, three-valve multi-dimensional liquid chromatograph according to claim 1, wherein: a shunt valve (F) is further arranged between the first chromatographic pump (P1) and the Sample Injector (SIL), a bypass flow channel is connected to the shunt valve (F), and the bypass flow channel is connected with an outlet of the Sample Injector (SIL) through a tee joint.
3. A three-pump, three-valve multi-dimensional liquid chromatograph according to claim 1, wherein: the chromatographic columns are respectively a first chromatographic column (C1), a second chromatographic column (C2) and a third chromatographic column (C3), the first chromatographic column (C1) is arranged on the first multi-way valve (A), and the first chromatographic column (C1) is an online solid-phase extraction column for bidirectional separation; the second chromatographic column (C2) is arranged on the second multi-way valve (B), and the second chromatographic column (C2) is an online analytical column or an online solid-phase extraction column; the third chromatographic column (C3) is arranged on the third multi-way valve (C), and the third chromatographic column (C3) is an online analytical column.
4. A three-pump, three-valve multi-dimensional liquid chromatograph according to claim 3, wherein: the first multi-way valve (A), the second multi-way valve (B) and the third multi-way valve (C) are two-position six-way valves, a first chromatographic column (C1) is connected between a first port and a fourth port of the first multi-way valve (A), a second port of the first multi-way valve (A) is connected with a sixth port of the second multi-way valve (B), a third port of the first multi-way valve (A) is connected with the second chromatographic pump (P2), a fifth port of the first multi-way valve (A) is connected with a second port of the second multi-way valve (B), and a sixth port of the first multi-way valve (A) is connected with a Sample Injector (SIL) of the first chromatographic pump (P1); a second chromatographic column (C2) is connected between a first port and a fourth port of the second multi-way valve (B), a third port of the second multi-way valve (B) is connected with a first waste liquid pool (V1) through a first waste liquid flow channel, and a fifth port of the second multi-way valve (B) is connected with a sixth port of the third multi-way valve (C); and a third chromatographic column (C3) is connected between the first port and the fourth port of the third multi-way valve (C), the second port of the third multi-way valve (C) is connected with the third chromatographic pump (P3), the third port of the third multi-way valve (C) is connected with the analysis flow channel, and the fifth port of the third multi-way valve (C) is connected with a second waste liquid pool (V2) through a second waste liquid flow channel.
5. The three-pump, three-valve multi-dimensional liquid chromatograph of claim 4, wherein: and the sixth port of the first multi-way valve (A) is connected with the second port of the second multi-way valve (B), and the fifth port of the first multi-way valve (A) is connected with a Sample Injector (SIL) of a first chromatographic pump (P1).
6. A three-pump, three-valve multi-dimensional liquid chromatograph according to claim 3, wherein: also comprises a third waste liquid flow channel which is connected with a third waste liquid pool (V3), the first multi-way valve (A) adopts a three-position seven-way valve, the second multi-way valve (B) and the third multi-way valve (C) adopt a two-position six-way valve, the first chromatographic column (C1) is connected between the first port and the fourth port of the first multi-way valve (A), the second port of the first multi-way valve (A) is connected with the second chromatographic pump (P2), the third port of the first multi-way valve (A) is connected with the sixth port of the second multi-way valve (B), a fifth port of the first multi-way valve (A) is connected with a Sample Injector (SIL) of the first chromatographic pump (P1), a sixth port of the first multi-way valve (A) is connected with a second port of the second multi-way valve (B), the seventh port of the first multi-way valve (A) is connected with a third waste liquid pool (V3) through the third waste liquid channel; the first port and the fourth port of the second multi-way valve (B) are connected with the second chromatographic column (C2), the third port of the second multi-way valve (B) is connected with the first waste liquid pool (V1) through the first waste liquid channel, the fifth port of the second multi-way valve (B) is connected with the sixth port of the third multi-way valve (C), the third chromatographic column (C3) is connected between the first port and the fourth port of the third multi-way valve (C), the second port of the third multi-way valve (C) is connected with the third chromatographic pump (P3), the third port of the third multi-way valve (C) is connected with the analysis channel, and the fifth port of the third multi-way valve (C) is connected with the second waste liquid pool (V2) through the second waste liquid channel.
7. A three-pump, three-valve multi-dimensional liquid chromatograph according to claim 6, wherein: and the sixth port of the first multi-way valve (A) is connected with a Sample Injector (SIL) of a first chromatographic pump (P1), and the fifth port of the first multi-way valve (A) is connected with the second port of the second multi-way valve (B).
8. The three-pump, three-valve multi-dimensional liquid chromatograph of any of claims 1-6, wherein: the analysis flow channel and the second waste liquid flow channel are both provided with a three-way valve, and a drainage pipeline is connected between the analysis flow channel and the second waste liquid flow channel through the three-way valve.
9. The three-pump, three-valve multi-dimensional liquid chromatograph of any of claims 1-6, wherein: the first (P1), second (P2) and third (P3) chromatography pumps are binary, quaternary or single pumps.
10. The three-pump, three-valve multi-dimensional liquid chromatograph of any of claims 1-6, wherein: the detector (D) is an ultraviolet detector (UV), a Diode Array Detector (DAD), a single-pole Mass Spectrometer (MS) or a triple quadrupole mass spectrometer (MS/MS).
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| CN202120591868.9U CN215066381U (en) | 2021-03-23 | 2021-03-23 | Multidimensional liquid chromatograph with three pumps and three valves |
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| CN202120591868.9U CN215066381U (en) | 2021-03-23 | 2021-03-23 | Multidimensional liquid chromatograph with three pumps and three valves |
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