CN213749907U

CN213749907U - Immunodiagnostic system

Info

Publication number: CN213749907U
Application number: CN202022393367.8U
Authority: CN
Inventors: 于鸫; 刘丽萍; 祁世泽
Original assignee: Guangdong Weishi Biotechnology Co Ltd
Current assignee: Guangdong Weishi Biotechnology Co Ltd
Priority date: 2020-10-23
Filing date: 2020-10-23
Publication date: 2021-07-20
Anticipated expiration: 2030-10-23

Abstract

The application relates to the technical field of biomedical detection equipment, in particular to an immunodiagnosis system. The immunodiagnostic system comprises a frame, and a mechanical control device, a temperature control device, a pressure control device and a fluorescence detection device which are arranged in the frame. The card box is placed on mechanical control device, and mechanical control device can drive the card box and remove to first station or second station. The temperature control device and the pressure control device are arranged on two sides of the first station relatively, the card box can be refrigerated through the temperature control device, and the flow of samples in the card box can be controlled through the pressure control device. The fluorescence detection device is opposite to the second station so as to perform fluorescence detection on the sample in the cassette at the second station; therefore, the mechanical control device moves the card box according to the preset steps, and the pressure control device, the temperature control device and the fluorescence detection device act on the card box according to the preset steps, so that the immunodiagnosis of the sample in the card box can be conveniently and quickly finished, and the detection efficiency is improved.

Description

Immunodiagnostic system

Technical Field

The application relates to the technical field of biomedical detection equipment, in particular to an immunodiagnosis system.

Background

Currently, in an immunodiagnosis laboratory, a large number of samples are required to be immunodiagnosed every day, and thus, the detection efficiency needs to be improved.

SUMMERY OF THE UTILITY MODEL

An object of the utility model is to provide an immunodiagnosis system to improve immunodiagnosis's detection efficiency to a certain extent.

The utility model provides an immunodiagnosis system, which comprises a frame, a mechanical control device, a temperature control device, a pressure control device and a fluorescence detection device; the mechanical control device is used for placing a card box and can drive the card box to move so as to move the card box to a first station or a second station; the temperature control device and the pressure control device are oppositely arranged on two sides of the first station, and the temperature control device can act on the card box positioned on the first station so as to refrigerate the card box; said pressure control means being capable of acting on said cartridge at said first station to control the flow of samples within said cartridge; the fluorescence detection device can perform fluorescence detection on the card box positioned at the second station.

Further, the mechanical control device comprises a mounting support, a first bracket and a second bracket; the mounting support is connected with the rack, a first sliding table extending along a first direction is arranged on the mounting support, and the first bracket is connected to the mounting support in a sliding mode through the first sliding table so that the first bracket can move along the first direction; the first bracket is provided with a second sliding table extending along a second direction, and the second bracket is connected to the first bracket in a sliding manner through the second sliding table so as to enable the second bracket to move along the second direction; the first direction and the second direction are perpendicular to each other; the second bracket is provided with a mounting hole, and the card box can be placed in the mounting hole.

Furthermore, the number of the mounting holes is multiple, and the mounting holes are distributed at intervals in a matrix.

Further, the mechanical control device further comprises a first driving mechanism; the first driving mechanism comprises a first motor, a first screw rod and a first nut; the first motor is arranged on the mounting support, the first screw rod is arranged along the first direction, one end of the first screw rod is connected with the output end of the first motor, and the first motor can drive the first screw rod to rotate; the first nut is connected with the first bracket and is in threaded connection with the first screw rod.

Further, the mechanical control device further comprises a second driving mechanism; the second driving mechanism comprises a second motor, a second screw rod and a second nut; the second motor is arranged on the first bracket, the second screw is arranged along the second direction, one end of the second screw is connected with the output end of the second motor, and the second motor can drive the second screw to rotate; the second nut is connected with the second bracket and is in threaded connection with the second screw rod.

Further, the temperature control device comprises a thermal control assembly and a thermal control driving device; the thermal control assembly comprises a heat dissipation block, a thermoelectric cooler and a mounting block; the heat dissipation block is connected with the mounting block, the thermoelectric cooler is positioned between the heat dissipation block and the mounting block, a heat absorption surface of the thermoelectric cooler faces the heat dissipation block, and a heat dissipation surface of the thermoelectric cooler faces the mounting block; the driving end of the thermal control driving device is connected with the mounting block, and the thermal control driving device can drive the thermal control assembly to move along a third direction so as to enable the heat dissipation block to abut against the card box; the third direction is perpendicular to the first direction and the second direction.

Further, the pressure control device comprises a pressure block, a pressure regulator and a pressure block driving device; the pressing block driving device is arranged on the rack, the driving end of the pressing block driving device is connected with the pressing block, and the pressing block driving device can drive the pressing block to move along the third direction so as to enable the pressing block to be pressed on the card box; a sample chamber interface, a quantitative chamber interface, a waste liquid pool interface and a cleaning liquid interface are formed on the card box; one side of the pressing block facing the card box forms a first interface, a second interface, a third interface and a fourth interface; when the pressing block is pressed on the card box, the first interface is communicated with the sample chamber interface, the second interface is communicated with the quantitative chamber interface, the third interface is communicated with the waste liquid pool interface, and the fourth interface is communicated with the cleaning liquid interface; the card box is provided with an air inlet communicated with an external air source, a liquid inlet communicated with a cleaning liquid device and an unloading port for emptying; the air inlet can be communicated with the first interface and the second interface through the pressure regulator, the unloading port can be communicated with the third interface, and the liquid inlet can be communicated with the fourth interface.

Further, the pressing block driving device comprises a mounting plate, a third sliding table, a first connecting plate and a driving assembly; the mounting plate is connected with the top plate of the rack, a third sliding table extending along the third direction is arranged on the mounting plate, the first connecting plate is connected with the pressing block, and the first connecting plate is connected to the mounting plate in a sliding mode through the third sliding table; the driving assembly is connected with the top plate of the rack, and the driving end of the driving assembly is connected with the first connecting plate so as to drive the first connecting plate to move along the third direction.

Further, the driving assembly comprises a third motor, a third screw, a third nut, a second connecting plate and a fourth sliding table; the fourth sliding table is arranged on a side plate surface of the mounting plate, which is far away from the third sliding table, and extends along the third direction; the second connecting plate is connected with the mounting plate in a sliding mode through the fourth sliding table; a strip-shaped hole is formed in the mounting plate, the strip-shaped hole extends along the third direction, a connecting piece is arranged in the strip-shaped hole, and two ends of the connecting piece are respectively connected with the first connecting plate and the second connecting plate; the third motor is connected with the mounting plate, the third screw rod extends along the third direction, one end of the third screw rod is connected with the output end of the third motor, and the third motor can drive the third screw rod to rotate; the third nut is connected with the second connecting plate and is in threaded connection with the third screw rod.

Further, the fluorescence detection device comprises an objective lens, and the objective lens is connected with the second connecting plate.

Compared with the prior art, the beneficial effects of the utility model are that:

the utility model provides an immunodiagnosis system includes the frame and installs mechanical control device, temperature control device, pressure control device and fluorescence detection device in the frame. The card box that waits to detect can place on mechanical control device, and mechanical control device can drive the card box and move on the horizontal direction to make the card box can move to first station or second station department. The temperature control device and the pressure control device are arranged on the upper side and the lower side of the first station at intervals, the pressure control device is positioned above the first station and connected with a top plate of the frame, and the temperature control device is positioned below the first station and installed on the top plate of the frame. When the card box is moved to the first station, the temperature control device and the pressure control device can act on the card box, and the temperature control device can refrigerate the card box to provide proper reaction temperature for samples in the card box; the pressure control device can provide a motive force to the sample within the cartridge to control the flow of the sample within the cartridge. Fluorescence detection device hangs and installs on the roof of frame, and fluorescence detection device's sense terminal is just to the second station, and after the card box was removed to the second station, can carry out fluorescence detection through fluorescence detection device to the sample in the card box. Therefore, when the immunodiagnosis is required to be carried out on the sample, the card box provided with the sample to be detected is placed on the mechanical control device, then the card box is moved to the first station and the second station through the mechanical control device, and the pressure control device, the temperature control device and the fluorescence detection device act on the card box according to the preset steps, so that the immunodiagnosis of the sample in the card box is conveniently and quickly completed, and the detection efficiency is improved.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments or the technical solutions in the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without creative efforts.

Fig. 1 is a schematic structural diagram of an immunodiagnostic system according to an embodiment of the present invention;

fig. 2 is a schematic partial structural diagram of an immunodiagnostic system according to an embodiment of the present invention;

fig. 3 is a schematic structural diagram of a mechanical control device according to an embodiment of the present invention;

fig. 4 is a schematic structural diagram of a temperature control device according to an embodiment of the present invention;

fig. 5 is a schematic structural diagram of a pressure control device according to an embodiment of the present invention;

fig. 6 is a schematic structural diagram of a pressing block according to an embodiment of the present invention at a first viewing angle;

fig. 7 is a schematic structural diagram of a pressing block at a second viewing angle according to an embodiment of the present invention;

fig. 8 is a schematic structural diagram of a fluorescence detection device according to an embodiment of the present invention.

Reference numerals:

1-a frame, 2-a mechanical control device, 21-a mounting support, 22-a first bracket, 23-a second bracket, 24-a first slide, 25-a second slide, 26-a mounting hole, 27-a first motor, 28-a first screw, 29-a first nut, 210-a second motor, 211-a second screw, 3-a temperature control device, 31-a heat dissipation block, 32-a thermoelectric device, 33-a mounting block, 34-a thermal control drive device, 4-a pressure control device, 41-a pressure block, 42-a pressure rectifier, 43-a mounting plate, 44-a first connecting plate, 45-a third motor, 46-a third screw, 47-a second connecting plate, 48-a first interface, 49-a second interface, 410-a third interface, 411-fourth interface, 412-air inlet, 413-liquid inlet, 414-unloading port, 5-fluorescence detection device and 51-objective lens.

Detailed Description

The technical solution of the present invention will be described clearly and completely with reference to the accompanying drawings, and obviously, the described embodiments are some, but not all embodiments of the present invention.

The components of the embodiments of the present invention, as generally described and illustrated in the figures herein, may be arranged and designed in a wide variety of different configurations. Thus, the following detailed description of the embodiments of the present invention, presented in the accompanying drawings, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention.

Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative work belong to the protection scope of the present invention.

In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are only for convenience of description and simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and thus, should not be construed as limiting the present invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance.

In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood in specific cases to those skilled in the art.

The following describes some embodiments according to the present application with reference to fig. 1-8.

The application provides an immunodiagnostic system for assisting a sample in a cartridge to perform immunodiagnosis; as shown in fig. 1 and 2, the immunodiagnostic system comprises a frame 1, and a mechanical control device 2, a temperature control device 3, a pressure control device 4 and a fluorescence detection device 5 which are installed in the frame 1; wait to detect the card box and can place on mechanical control device 2, mechanical control device 2 can drive the card box and move on the horizontal direction to make the card box can move to first station or second station department. Temperature control device 3 and pressure control device 4 set up in the upper and lower both sides of first station along the third direction that vertical direction relative interval is promptly, and pressure control device 4 is located the top of first station and is connected with the roof of frame 1, and temperature control device 3 is located the below of first station and installs on the roof of frame 1. When the card box is moved to the first station, the temperature control device 3 and the pressure control device 4 can act on the card box, and the temperature control device 3 can refrigerate the card box to provide proper reaction temperature for samples in the card box; the pressure control device 4 is capable of providing a pushing force on the sample within the cartridge to control the flow of the sample within the cartridge. Fluorescence detection device 5 hangs and installs on the roof of frame 1, and fluorescence detection device 5's sense terminal is just to the second station, and after the card box was moved to the second station, can carry out fluorescence detection through fluorescence detection device 5 to the sample in the card box.

Therefore, when the immunodiagnosis is required to be carried out on a sample, the card box provided with the sample to be detected is placed on the mechanical control device 2, then the card box is moved to the first station and the second station through the mechanical control device 2, and the pressure control device 4, the temperature control device 3 and the fluorescence detection device 5 are made to act on the card box according to the preset steps, so that the immunodiagnosis of the sample in the card box is conveniently and quickly completed, and the detection efficiency is improved.

In this embodiment, preferably, as shown in fig. 3, the machine control device 2 includes a mounting base 21, a first bracket 22, a second bracket 23, a first drive mechanism, and a second drive mechanism.

The mounting support 21 comprises a first support and a second support, the first support and the second support are arranged oppositely at intervals along a second direction, and the upper ends of the first support and the second support are respectively provided with a first sliding table 24 extending along the first direction; the first bracket 22 is horizontally disposed, and two ends of the first bracket 22 along the second direction are respectively connected with the first support and the second support in a sliding manner through two first sliding tables 24, so that the first bracket 22 can slide along the first direction. The first driving mechanism is used for driving the first bracket 22 to move, and preferably comprises a first motor 27, a first screw 28 and a first nut 29; the first motor 27 is fixedly connected with the first support through a fixing support, the first screw 28 is arranged along the first direction, one end of the first screw 28 is connected with the output end of the first motor 27 through a coupler, and the first screw 28 can be driven to rotate through the first motor 27. The first nut 29 is screwed on the first screw 28, and the first nut 29 is fixedly connected to the first bracket 22, so that when the first motor 27 drives the first screw 28 to rotate, the first nut 29 drives the first bracket 22 to move along the first direction through the thread transmission between the first screw 28 and the first nut 29.

The two ends of the first bracket 22 along the first direction are provided with second sliding tables 25, and the length of each second sliding table 25 extends along the second direction; both ends of the second bracket 23 are slidably connected with the first bracket 22 through two second sliding tables 25, respectively, so that the second bracket 23 can slide in the second direction relative to the first bracket 22. The second driving mechanism is used for driving the second bracket 23 to move, and preferably, the second driving mechanism comprises a second motor 210, a second screw 211 and a second nut; the second motor 210 is fixedly connected with the first bracket 22 through a fixing support, the second screw 211 is arranged along the second direction, one end of the second screw 211 is connected with the output end of the second motor 210 through a coupler, and the second screw 211 can be driven to rotate through the second motor 210. The second nut is screwed on the second screw 211 and is connected with the second bracket 23, so that when the second motor 210 drives the second screw 211 to rotate, the second nut can drive the second bracket 23 to move along the second direction through the thread transmission between the second screw 211 and the second nut.

The cartridge is placed on the second bracket 23, and by the movement of the first and

second brackets

22 and 23, the cartridge can be moved in the first and second directions to move the cartridge to a first station between the pressure control device 4 and the temperature control device 3 for sample processing or to move the cartridge to a second station below the fluorescence detection device 5 for fluorescence detection. In this embodiment, preferably, the second bracket 23 has a mounting hole 26, a step is formed on a side wall of the mounting hole 26, the cartridge can be placed in the mounting hole 26, and an edge of a bottom wall of the cartridge can be overlapped on the step in the mounting hole 26, so that when the second bracket 23 drives the cartridge to move to the first station, the temperature control device 3 located below the first station can abut against the bottom wall of the cartridge to act on the cartridge and cool the cartridge. Preferably, the number of the mounting holes 26 on the second bracket 23 is plural, and the plural mounting holes 26 are arranged at intervals in a matrix, so that it is possible to place plural cartridges containing samples on the second bracket 23 and then process the plural samples in sequence.

In one embodiment of the present application, the temperature control device 3 is used to cool the cartridge, preferably, as shown in fig. 4, the temperature control device 3 includes a thermal control assembly and a thermal control drive 34; the thermal control assembly comprises a heat dissipation block 31, a thermoelectric cooler 32 and an installation block 33, the thermoelectric cooler 32 and the heat dissipation block 31 are sequentially arranged on the installation block 33, the heat dissipation block 31 is connected with the installation block 33, the thermoelectric cooler 32 is clamped between the heat dissipation block 31 and the installation block 33, the heat absorption surface of the thermoelectric cooler 32 is attached to the heat dissipation block 31, and the heat dissipation surface of the thermoelectric cooler 32 is attached to the installation block 33. The driving end of the thermal control driving device 34 is connected with the mounting block 33 of the thermal control assembly, and the thermal control driving device 34 can drive the thermal control assembly to move along the vertical direction, so that the heat dissipation block 31 of the thermal control assembly abuts against the bottom wall of the card box located at the first station. When the thermoelectric cooler 32 is powered on to work, the heat absorbing surface of the thermoelectric cooler 32 can absorb the heat in the card box through the heat dissipating block 31, transfer the absorbed heat to the heat dissipating surface of the thermoelectric cooler 32, and finally dissipate the heat through the mounting block 33, so that the card box is cooled, and the sample in the card box is at a proper reaction temperature.

It should be noted that the thermal control driving device 34 may be an air cylinder and a hydraulic cylinder, or may be a linear motor, as long as the thermal control assembly can be driven to move in the vertical direction.

In one embodiment of the present application, the pressure control device 4 is used to control the flow of fluid within the cartridge; preferably, as shown in fig. 5, the pressure control device 4 includes a pressure piece 41, a pressure regulator 42, and a pressure piece driving device; the pressing block driving device is connected with the pressing block 41, and the pressing block driving device can drive the pressing block 41 to move in the vertical direction, so that the pressing block 41 is pressed on the card box located at the first station.

In this embodiment, a sample chamber, a quantification chamber, a distribution chamber, a detection zone and a waste liquid pool are formed in the cartridge; the card box is also provided with a micro-channel, and the sample chamber, the quantitative chamber, the shunt chamber, the detection side region and the waste liquid pool are communicated in sequence through the micro-channel. A sample chamber interface communicated with the feed end of the sample chamber, a quantitative chamber interface communicated with the front end of the quantitative chamber and a waste liquid tank interface communicated with the waste liquid tank are formed on the upper end surface of the card box; the upper end face of the card box is also provided with an emptying hole communicated with the rear end of the quantitative chamber, the emptying hole is covered with a hydrophobic membrane, and a micro-channel used for communicating the quantitative chamber and the shunting chamber is connected between the quantitative chamber and the emptying hole. And a cleaning liquid interface is also formed on the upper end surface of the card box and can be communicated with the detection area through a micro-channel formed in the card box.

Preferably, as shown in fig. 6 and 7, a first interface 48, a second interface 49, a third interface 410 and a fourth interface 411 are formed on the end surface of the pressing block 41 facing to the cartridge, when the pressing block 41 is pressed on the cartridge, the first interface 48 is communicated with the sample chamber interface, the second interface 49 is communicated with the quantitative chamber interface, the third interface 410 is communicated with the waste liquid pool interface, and the fourth interface 411 is communicated with the cleaning liquid interface. The pressure block 41 is provided with an air inlet 412 which is used for being communicated with an external air source, the pressure regulator 42 is arranged on the pressure block 41, the air inlet 412 can be communicated with an inlet of the pressure regulator 42 through a flow channel formed inside the pressure block 41, an outlet of the pressure regulator 42 can be communicated with the first interface 48 and the second interface 49 through the flow channel formed inside the pressure block 41, and therefore air with certain pressure outside is conveyed into a sample chamber and a quantitative chamber of the cartridge through the first interface 48 and the second interface 49 after being regulated to preset pressure through the pressure regulator 42, and therefore pushing force is provided for samples in the sample chamber or samples in the quantitative chamber.

The pressing block 41 is provided with an unloading port 414 for emptying, the unloading port 414 can be communicated with a waste liquid pool interface through a flow channel formed in the cartridge, and the pressure in the cartridge can be exhausted and unloaded through the unloading port 414. The pressing block 41 is provided with a liquid inlet 413 communicated with an external cleaning liquid device, and the liquid inlet 413 can be communicated with a cleaning liquid interface through a flow channel formed in the card box, so that cleaning liquid is introduced into the card box.

It should be noted that the pressing block 41 is further provided with a first valve, a second valve, a third valve and a fourth valve; the first valve is connected to a flow passage for communicating the first port 48 with the outlet of the pressure regulator 42, and the communication between the first port 48 and the pressure regulator 42 can be opened or cut off through the first valve; the second valve is connected to a flow passage for communicating the second port 49 with an outlet of the pressure regulator 42, and the communication between the second port 49 and the pressure regulator 42 can be opened or closed through the second valve; the third valve is connected to a flow passage for communicating the third interface 410 with the unloading port 414, and the communication between the unloading port 414 and the third interface 410 can be opened or closed through the third valve; the fourth valve is connected to a flow channel for communicating the fourth port 411 with the liquid inlet 413, and the communication between the fourth port 411 and the liquid inlet 413 can be opened or cut off through the fourth valve.

When the flow of the sample in the cartridge is controlled by the pressure control means 4, the sample is placed in the sample chamber of the cartridge; firstly, the third valve is closed, the first valve is opened, external air is conveyed into the sample chamber through the first interface 48 and the sample chamber interface after the pressure of the external air is adjusted by the pressure adjuster 42, so that a sample in the sample chamber is pushed to flow into the quantitative chamber, and the air in the quantitative chamber passes through the hydrophobic membrane and is exhausted through an exhaust port at the rear end of the quantitative chamber; and because the third valve is closed, the gas in other cavities such as the shunting chamber at the rear end of the quantitative chamber and the like can not be discharged, so that the sample can not continuously flow to the subsequent cavity after entering the quantitative chamber.

When the sample is full of the quantitative chamber, the first valve is closed, the third valve is opened, the second valve is opened, external gas enters the quantitative chamber through the second interface 49 and the quantitative chamber interface after the pressure of the external gas is adjusted by the pressure adjuster 42, so that the sample in the quantitative chamber is pushed to flow into the shunting chamber, and the gas in the shunting chamber and the subsequent chambers is discharged through the waste liquid pool interface, the third interface 410 and the unloading port 414, so that the sample can smoothly flow into the shunting chamber; it should be noted that, since the drain hole at the rear end of the dosing chamber is covered with the hydrophobic film, the product does not flow out of the drain hole.

And after the sample flows into the shunting chamber, closing the third valve and the second valve to ensure that the sample stays in the shunting chamber for a preset time to react with the dynamic fluorescent agent in the shunting chamber. And after the reaction is finished, the third valve and the second valve are opened again, and the sample in the shunting chamber is continuously pushed to the detection area. After sending the sample to the detection zone, close second valve and third valve to move the card box to fluorescence detection device 5 below through mechanical control device 2 control and be the second station, make fluorescence detection device 5 just to the detection zone of card box, carry out fluorescence detection to the sample in the card box. Remove the card box back to first station again after accomplishing fluorescence detection, make briquetting 41 act on the card box again, then open third valve and fourth valve, make the washing liquid can get into the card box and reach the detection zone, wash the sample in the detection zone to make the waste liquid after the washing flow into in the waste liquid pool.

After the detection of the sample in one cartridge is completed, another cartridge is moved to the first station, and the above steps are repeated to continue to assist the sample in the new cartridge to complete the processing of the sample.

In one embodiment of the present application, the mass drive device is configured to drive the mass 41 to move in a vertical direction, such that the mass 41 can be pressed onto the cartridge to control the flow of the sample within the cartridge. Preferably, as shown in fig. 5, the briquetting driving device includes a mounting plate 43, a third sliding table, a first connecting plate 44 and a driving assembly; the mounting plate 43 is connected with the top plate of the frame 1, a third sliding table is arranged on one side plate surface of the mounting plate 43 and arranged along the vertical direction, the first connecting plate 44 is connected to the mounting plate 43 in a sliding mode through the third sliding table, and the first connecting plate 44 is used for being connected with the pressing block 41; the driving assembly is connected with the mounting plate 43, the driving end of the driving assembly is connected with the first connecting plate 44, and the driving assembly can drive the first connecting plate 44 to move along the vertical direction, so that the pressing block 41 is driven to move along the vertical direction.

Preferably, as shown in fig. 5 and 8, the driving assembly includes a third motor 45, a third screw 46, a third nut, a second connecting plate 47, and a fourth slide table;

the fourth slip table sets up on the side face that mounting panel 43 deviates from the third slip table, and the fourth slip table sets up along vertical direction, and second connecting plate 47 passes through fourth slip table sliding connection on mounting panel 43. The mounting panel 43 is provided with a strip-shaped hole, the length direction of the strip-shaped hole extends along the vertical direction, a connecting piece is arranged in the strip-shaped hole, and two ends of the connecting piece are respectively connected with the first connecting plate 44 and the second connecting plate 47, so that the first connecting plate 44 and the second connecting plate 47 can synchronously move along the vertical direction.

The third motor 45 is installed on the installation plate 43, the third screw rod 46 is arranged along the vertical direction, one end of the third screw rod 46 is connected with the output end of the third motor 45 through a coupler, and the third motor 45 can drive the third screw rod 46 to rotate. The third nut is screwed on the third screw rod 46, and the third nut is connected with the mounting plate 43, so that when the third motor 45 drives the third screw rod 46 to rotate, the third nut can drive the first connecting plate 44 and the second connecting plate 47 to move along the vertical direction through the thread transmission between the third screw rod 46 and the third nut, and further drive the pressing block 41 to move along the vertical direction.

In one embodiment of the present application, the fluorescence detection device 5 is used for performing fluorescence detection on a sample in the cartridge, and the structure of the fluorescence detection device 5 and how to perform fluorescence detection on the sample and obtain a detection result are common knowledge to those skilled in the art, and will not be described herein again. Preferably, as shown in fig. 8, the objective lens 51 of the fluorescence detecting device 5 is mounted on the second connecting plate 47 so that the objective lens 51 can move in the vertical direction with the second connecting plate 47 to adjust the distance between the objective lens 51 and the cartridge below the objective lens 51. Preferably, the laser light source of the fluorescence detection device 5 is a 695 nanometer laser light source.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention.

Claims

1. An immunodiagnosis system is characterized by comprising a frame, a mechanical control device, a temperature control device, a pressure control device and a fluorescence detection device;

the mechanical control device is used for placing a card box and can drive the card box to move so as to move the card box to a first station or a second station;

the temperature control device and the pressure control device are oppositely arranged on two sides of the first station, and the temperature control device can act on the card box positioned on the first station so as to refrigerate the card box; said pressure control means being capable of acting on said cartridge at said first station to control the flow of samples within said cartridge;

the fluorescence detection device can perform fluorescence detection on the card box positioned at the second station.

2. The immunodiagnostic system of claim 1, wherein the mechanical control device comprises a mounting support, a first bracket, and a second bracket;

the mounting support is connected with the rack, a first sliding table extending along a first direction is arranged on the mounting support, and the first bracket is connected to the mounting support in a sliding mode through the first sliding table so that the first bracket can move along the first direction;

the first bracket is provided with a second sliding table extending along a second direction, and the second bracket is connected to the first bracket in a sliding manner through the second sliding table so as to enable the second bracket to move along the second direction;

the first direction and the second direction are perpendicular to each other;

the second bracket is provided with a mounting hole, and the card box can be placed in the mounting hole.

3. The immunodiagnostic system of claim 2, wherein the number of the mounting holes is a plurality, and the plurality of mounting holes are arranged in a matrix at intervals.

4. The immunodiagnostic system of claim 2, wherein the mechanical control device further comprises a first drive mechanism;

the first driving mechanism comprises a first motor, a first screw rod and a first nut;

the first motor is arranged on the mounting support, the first screw rod is arranged along the first direction, one end of the first screw rod is connected with the output end of the first motor, and the first motor can drive the first screw rod to rotate;

the first nut is connected with the first bracket and is in threaded connection with the first screw rod.

5. The immunodiagnostic system of claim 2, wherein the mechanical control device further comprises a second drive mechanism;

the second driving mechanism comprises a second motor, a second screw rod and a second nut;

the second motor is arranged on the first bracket, the second screw is arranged along the second direction, one end of the second screw is connected with the output end of the second motor, and the second motor can drive the second screw to rotate;

the second nut is connected with the second bracket and is in threaded connection with the second screw rod.

6. The immunodiagnostic system of claim 2, wherein the temperature control device comprises a thermal control assembly and a thermal control drive;

the thermal control assembly comprises a heat dissipation block, a thermoelectric cooler and a mounting block; the heat dissipation block is connected with the mounting block, the thermoelectric cooler is positioned between the heat dissipation block and the mounting block, a heat absorption surface of the thermoelectric cooler faces the heat dissipation block, and a heat dissipation surface of the thermoelectric cooler faces the mounting block;

the driving end of the thermal control driving device is connected with the mounting block, and the thermal control driving device can drive the thermal control assembly to move along a third direction so as to enable the heat dissipation block to abut against the card box;

the third direction is perpendicular to the first direction and the second direction.

7. The immunodiagnostic system of claim 6, wherein the pressure control device comprises a pressure block, a pressure rectifier, and a pressure block drive;

the pressing block driving device is arranged on the rack, the driving end of the pressing block driving device is connected with the pressing block, and the pressing block driving device can drive the pressing block to move along the third direction so as to enable the pressing block to be pressed on the card box;

a sample chamber interface, a quantitative chamber interface, a waste liquid pool interface and a cleaning liquid interface are formed on the card box;

one side of the pressing block facing the card box forms a first interface, a second interface, a third interface and a fourth interface;

when the pressing block is pressed on the card box, the first interface is communicated with the sample chamber interface, the second interface is communicated with the quantitative chamber interface, the third interface is communicated with the waste liquid pool interface, and the fourth interface is communicated with the cleaning liquid interface;

the card box is provided with an air inlet communicated with an external air source, a liquid inlet communicated with a cleaning liquid device and an unloading port for emptying;

the air inlet can be communicated with the first interface and the second interface through the pressure regulator, the unloading port can be communicated with the third interface, and the liquid inlet can be communicated with the fourth interface.

8. The immunodiagnostic system of claim 7, wherein the compact drive device comprises a mounting plate, a third slide, a first connecting plate, and a drive assembly;

the mounting plate is connected with the top plate of the rack, a third sliding table extending along the third direction is arranged on the mounting plate, the first connecting plate is connected with the pressing block, and the first connecting plate is connected to the mounting plate in a sliding mode through the third sliding table;

the driving assembly is connected with the top plate of the rack, and the driving end of the driving assembly is connected with the first connecting plate so as to drive the first connecting plate to move along the third direction.

9. The immunodiagnostic system of claim 8, wherein the drive assembly comprises a third motor, a third screw, a third nut, a second connecting plate, and a fourth ramp;

the fourth sliding table is arranged on a side plate surface of the mounting plate, which is far away from the third sliding table, and extends along the third direction; the second connecting plate is connected with the mounting plate in a sliding mode through the fourth sliding table;

a strip-shaped hole is formed in the mounting plate, the strip-shaped hole extends along the third direction, a connecting piece is arranged in the strip-shaped hole, and two ends of the connecting piece are respectively connected with the first connecting plate and the second connecting plate;

the third motor is connected with the mounting plate, the third screw rod extends along the third direction, one end of the third screw rod is connected with the output end of the third motor, and the third motor can drive the third screw rod to rotate;

the third nut is connected with the second connecting plate and is in threaded connection with the third screw rod.

10. The immunodiagnostic system of claim 9, wherein the fluorescence detection device comprises an objective lens, the objective lens coupled to the second connection plate.