CN116500249B - Detection device for immunodiagnosis - Google Patents
Detection device for immunodiagnosis Download PDFInfo
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- CN116500249B CN116500249B CN202310215432.3A CN202310215432A CN116500249B CN 116500249 B CN116500249 B CN 116500249B CN 202310215432 A CN202310215432 A CN 202310215432A CN 116500249 B CN116500249 B CN 116500249B
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- 238000001514 detection method Methods 0.000 title claims abstract description 76
- 239000007788 liquid Substances 0.000 claims abstract description 45
- 230000007246 mechanism Effects 0.000 claims abstract description 24
- 238000001125 extrusion Methods 0.000 claims description 50
- 230000002457 bidirectional effect Effects 0.000 claims description 48
- 230000006835 compression Effects 0.000 claims description 41
- 238000007906 compression Methods 0.000 claims description 41
- 238000007789 sealing Methods 0.000 claims description 14
- 230000000087 stabilizing effect Effects 0.000 claims description 7
- 230000000694 effects Effects 0.000 abstract description 10
- 230000008094 contradictory effect Effects 0.000 abstract description 3
- 230000009977 dual effect Effects 0.000 abstract description 3
- 239000003344 environmental pollutant Substances 0.000 abstract description 3
- 231100000719 pollutant Toxicity 0.000 abstract description 3
- 230000011218 segmentation Effects 0.000 abstract description 3
- 238000000034 method Methods 0.000 description 5
- 101000623895 Bos taurus Mucin-15 Proteins 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000013399 early diagnosis Methods 0.000 description 1
- 238000003018 immunoassay Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/5302—Apparatus specially adapted for immunological test procedures
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a detection device for immunodiagnosis, which comprises an adjustable fixed bearing detection mechanism, a concentric alignment device, a reciprocating forward and reverse alternating rotary mixing fixing device, a split type mixing drip device and a detection card box fixing assembly. The invention belongs to the technical field of immunodetection, in particular to a detection device for immunodiagnosis, which adopts a mode of combining multiple adjustments according to the condition that a detection result is inaccurate due to easy deflection and easy carrying of pollutants when a sample liquid is dripped, so as to realize the technical effect of accurately dripping the center of the sample liquid and further improve the detection accuracy; according to the contradictory characteristics that the dropper is hard (convenient to fix and not easy to skew) and soft (convenient to extrude liquid), the dropper is creatively arranged to be combined with soft and hard in a segmentation mode, so that the dual technical effects of flexibly extruding liquid and rigidly supporting not skew are achieved.
Description
Technical Field
The invention belongs to the technical field of immunodetection, and particularly relates to a detection device for immunodiagnosis.
Background
The immunodiagnosis is of outstanding value for helping clinical timely and accurate early diagnosis, effectively treating early stage, reducing the death rate of illness, avoiding abusing antibiotics and reducing bacterial drug resistance. The current kit for immunodiagnosis and detection generally comprises a detection card box, a buffer solution, a sampler and the like, wherein a proper amount of sample is taken by the sampler, added into the buffer solution and uniformly mixed, then dripped into a sample adding hole of the detection card box, and the sample is put into a fluorescent instrument for reading the result after a few minutes. On one hand, the existing mixing operation is generally carried out by shaking by hand, so that the condition of uneven mixing exists, and the detection result is affected; on the other hand, when the liquid to be detected is dripped into the sample adding hole of the detection card box, the situation that the liquid is inclined is easy to occur, the accurate dripping in the center positioning mode cannot be realized, the volume of the dripped liquid is not only influenced, but also when the liquid with the inclined dripping flows into the sample adding hole again, surface attachments near the sample adding hole are easy to be brought in, and the accuracy of the detection result is further influenced.
Disclosure of Invention
Aiming at the situation, in order to overcome the defects of the prior art, the invention provides the detection device for immunodiagnosis, which adopts a reciprocating forward and reverse alternate rotary mixing mode to realize the technical effect of uniformly mixing the sample liquid by rotating the sample liquid in the forward and reverse directions according to the condition that the sample liquid for immunodetection is uniformly mixed; according to the condition that the detection result is inaccurate due to easy deflection and easy carrying of pollutants when the sample liquid is dripped, a mode of combining multiple adjustments is adopted, so that the technical effect of accurately dripping the center of the sample liquid is realized, and the detection accuracy is further improved; according to the contradictory characteristics that the dropper is hard (convenient to fix and not easy to skew) and soft (convenient to extrude liquid), the dropper is creatively arranged to be combined with soft and hard in a segmentation mode, so that the dual technical effects of flexibly extruding liquid and rigidly supporting not skew are achieved.
The technical scheme adopted by the invention is as follows: the invention provides a detection device for immunodiagnosis, which comprises an adjustable fixed bearing detection mechanism, a concentric alignment device, a reciprocating forward and reverse alternating rotary mixing fixing device, a split type mixing drip device and a detection card box fixing component, wherein the concentric alignment device is arranged on the adjustable fixed bearing detection mechanism, the reciprocating forward and reverse alternating rotary mixing fixing device is arranged on the concentric alignment device, the split type mixing drip device is movably arranged on the reciprocating forward and reverse alternating rotary mixing fixing device, and the detection card box fixing component is movably arranged on the adjustable fixed bearing detection mechanism; the reciprocating forward and reverse alternate type rotary mixing fixing device comprises a forward and reverse mixing disc, a rotary clamping piece, a fixed sliding frame, a reciprocating driving assembly, a fixing assembly and a limiting extrusion liquid outlet assembly, wherein the fixing assembly is arranged on the concentric alignment device, the forward and reverse mixing disc is arranged on the fixing assembly, the reciprocating driving assembly is arranged on the fixing assembly, the fixed sliding frame is arranged on the fixing assembly, the rotary clamping piece is connected with the reciprocating driving assembly, the rotary clamping piece is clamped and slides in the fixed sliding frame, the rotary clamping piece is meshed with the forward and reverse mixing disc and is connected with the forward and reverse mixing disc, and the limiting extrusion liquid outlet assembly is arranged on the bottom wall of the forward and reverse mixing disc.
Further, the forward and reverse mixing disc comprises a rotary disc body, a rotary groove, an open-type convex ring, meshing columns and a clamping groove, wherein the rotary disc body is connected with the fixing assembly through the clamping groove, a magnetic attraction ring is arranged on the bottom wall of the rotary disc body, the rotary groove is formed in the rotary disc body, the open-type convex ring is arranged in the rotary groove, and the meshing columns are uniformly arranged on the open-type convex ring at intervals.
Preferably, the rotating clamping piece comprises a clamping column, a clamping piece and a clamping sliding block, the clamping column is clamped and rotated to be arranged in the rotating groove, the clamping piece is arranged on the clamping column, the clamping piece is meshed with the meshing column to be connected, and the clamping sliding block is clamped and slidingly arranged in the fixed sliding frame.
Further, the reciprocating driving assembly comprises a driving motor, a first rotating member and a second rotating member, wherein the driving motor is arranged on the fixed assembly, the first rotating member is connected with the output end of the driving motor, and the second rotating member is connected with the first rotating member; the first rotating piece comprises a first driving frame and a first driving column, the first driving frame is connected with the output end of the driving motor, and the first driving column is arranged on the first driving frame in a sliding manner; the second rotating part comprises a second driving frame and a second driving column, the second driving frame is connected with the clamping sliding block, the second driving column is in crisscross connection with the first driving column, the second driving column is slidably arranged in the second driving frame, and the first driving frame and the second driving frame are oppositely arranged.
The fixing assembly comprises a clamping ring, a mountain-shaped fixing rod and a fixing disc, wherein the fixing disc is arranged on the concentric alignment device, the clamping ring is clamped in the clamping groove, and the mountain-shaped fixing rod is respectively connected with the clamping ring, the fixing sliding frame and the fixing disc.
Further, the limiting extrusion liquid outlet component comprises a fixed plate, an extrusion telescopic piece, a stable frame and a buckling limiting piece, wherein the fixed plate is arranged on the bottom wall of the turntable body, the extrusion telescopic piece is arranged on the fixed plate, the stable frame is connected with the movable end of the extrusion telescopic piece, and the buckling limiting piece is arranged on the stable frame; the buckling limiting piece comprises a rotating shaft, a first buckling piece, a second buckling piece and a telescopic spring, wherein the rotating shaft is arranged on the stabilizing frame, one rotation of the buckling piece is arranged on the rotating shaft, the second buckling piece is arranged on the rotating shaft in a rotating mode, and the telescopic spring is arranged between the first buckling piece and the second buckling piece.
As a further preferred aspect of the present invention, the split type mixing dropping device includes an upper fixed pipe, a flexible bag portion, a lower fixed pipe, a magnetic sealing cover, a connecting rod and a sliding rail type blocking extrusion liquid outlet member, wherein the magnetic sealing cover is detachably arranged at an opening of the upper fixed pipe, the flexible bag portion is connected with the upper fixed pipe, the lower fixed pipe is connected with the flexible bag portion, the connecting rod is arranged on side walls of the upper fixed pipe and the lower fixed pipe, and the sliding rail type blocking extrusion liquid outlet member is arranged at the bottom end of the lower fixed pipe; the sliding rail type plugging extrusion liquid outlet piece comprises a rail, a magnetic plugging plate, an extrusion rod and an extrusion plate, wherein the rail is arranged at the bottom end of the lower fixed pipe, the magnetic plugging plate is magnetically attracted to the bottom surface of the lower fixed pipe, the magnetic plugging plate is clamped and slidingly arranged in the rail, the extrusion rod is connected with the magnetic plugging plate, and the extrusion plate is connected with the extrusion rod.
Further, the concentric alignment device comprises an alignment telescopic rod I, an alignment telescopic rod II, a fixed block, a bearing block, a concentric alignment part I and a concentric alignment part II, wherein the alignment telescopic rod I is arranged on the adjustable fixed bearing detection mechanism, the alignment telescopic rod II is arranged on the adjustable fixed bearing detection mechanism, the alignment telescopic rod I and the alignment telescopic rod II are vertically arranged, the fixed block is respectively arranged at the movable ends of the alignment telescopic rod I and the alignment telescopic rod II, the bearing block is arranged on the bottom wall of the fixed block, the concentric alignment part I is arranged on the bearing block, the concentric alignment part II is arranged on the bearing block, the concentric alignment part I and the concentric alignment part II are vertically arranged, and the concentric alignment part II is arranged below the concentric alignment part; the concentric alignment member I comprises a connecting plate I, a limiting rod I, a bidirectional screw rod I, an alignment motor I and a motor fixing member I, wherein the limiting rod I is arranged on a bearing block, the connecting plate I is arranged at two ends of the limiting rod I, the bidirectional screw rod I is rotationally arranged on the bearing block, two ends of the bidirectional screw rod I are rotationally arranged on the connecting plate I, threads with opposite directions are arranged on the bidirectional screw rod I, the alignment rod I is sleeved on the limiting rod I and the bidirectional screw rod I, the alignment rod I is rotationally arranged on the limiting rod I, the alignment rod I is meshed and connected with the bidirectional screw rod I, the motor fixing member I is arranged on the connecting plate I, the alignment motor I is arranged on the motor fixing member I, and the output end of the alignment motor I is connected with the bidirectional screw rod I; the concentric alignment component II comprises a connecting plate II, a limiting rod II, a bidirectional screw rod II, an alignment motor II and a motor fixing component II, wherein the limiting rod II is arranged on the bearing block, the connecting plate II is arranged at two ends of the limiting rod II, the bidirectional screw rod II is rotationally arranged on the bearing block, two ends of the bidirectional screw rod II are rotationally arranged on the connecting plate II, threads with opposite directions are arranged on the bidirectional screw rod II, the alignment rod II is sleeved on the limiting rod II and the bidirectional screw rod II, the alignment rod II is rotationally arranged on the limiting rod II, the alignment rod II is meshed with the bidirectional screw rod II and is connected with the motor fixing component II, the alignment motor II is arranged on the motor fixing component II, and the output end of the alignment motor II is connected with the bidirectional screw rod II.
The detection card box fixing assembly comprises a clamping block, a vertical telescopic part, a transverse telescopic part, a connecting block, a meshing block and a compression stud, wherein the clamping block is clamped and slidably arranged on the adjustable fixed bearing detection mechanism, the vertical telescopic part is arranged on the clamping block, the connecting block is arranged at the movable end of the vertical telescopic part, the transverse telescopic part is arranged on the connecting block, the meshing block is arranged at the movable end of the transverse telescopic part, the compression stud is rotationally arranged on the meshing block, and the bottom of the compression stud is wrapped with a flexible layer.
Further, the adjustable fixed bearing detection mechanism comprises a supporting frame, a detection platform and a height adjusting piece, wherein the height adjusting piece is arranged on the bottom wall of the supporting frame, and the detection platform is arranged at the movable end of the height adjusting piece; the detection platform is provided with a moving groove, and the clamping block is clamped and slidably arranged in the moving groove.
The beneficial effects obtained by the invention by adopting the structure are as follows: according to the detection device for immunodiagnosis, according to the condition that the immunodetection sample liquid is uniformly mixed, the technical effect of uniformly mixing the sample liquid is realized by rotating the sample liquid in the forward and reverse directions in a reciprocating forward and reverse alternating rotating and uniformly mixing mode; according to the condition that the detection result is inaccurate due to easy deflection and easy carrying of pollutants when the sample liquid is dripped, a mode of combining multiple adjustments is adopted, so that the technical effect of accurately dripping the center of the sample liquid is realized, and the detection accuracy is further improved; according to the contradictory characteristics that the dropper is hard (convenient to fix and not easy to skew) and soft (convenient to extrude liquid), the dropper is creatively arranged to be combined with soft and hard in a segmentation mode, so that the dual technical effects of flexibly extruding liquid and rigidly supporting not skew are achieved.
Drawings
FIG. 1 is a schematic diagram of the whole structure of a detection device for immunodiagnosis according to the present invention;
FIG. 2 is a front view of a diagnostic immunoassay device according to the present invention;
fig. 3 is a schematic structural view of a reciprocating forward and reverse alternating rotary mixing fixing device;
FIG. 4 is a left side view of the reciprocating forward and reverse alternating rotary mixing fixture;
fig. 5 is a front view of the reciprocating forward and reverse alternating rotary mixing and fixing device;
FIG. 6 is a partial cross-sectional view of a reciprocating forward and reverse alternating rotary mixing fixture;
FIG. 7 is a schematic view of a limited extrusion assembly;
FIG. 8 is a front view of the positioning extrusion assembly;
FIG. 9 is a schematic view of a split mixing dropper;
FIG. 10 is a cross-sectional view of a divided mixing dropper;
FIG. 11 is a schematic illustration of the structure of a concentric alignment device;
FIG. 12 is a schematic structural view of a cartridge holder assembly;
fig. 13 is a schematic structural view of an adjustable fixed support detecting mechanism.
Wherein, 1, an adjustable fixed bearing detection mechanism, 2, a concentric alignment device, 3, a reciprocating forward and reverse alternating rotary mixing fixing device, 4, a split type mixing drip device, 5, a detection clamping box fixing component, 6, a forward and reverse mixing disc, 7, a rotary clamping piece, 8, a fixed sliding frame, 9, a reciprocating driving component, 10, a fixing component, 11, a limit extrusion liquid outlet component, 12, a turntable body, 13, a rotary groove, 14, an open convex ring, 15, a meshing column, 16, a clamping groove, 17, a magnetic attraction ring, 18, a clamping column, 19, a clamping piece, 20, a clamping slide block, 21, a driving motor, 22, a first rotating piece, 23, a second rotating piece, 24, a first driving frame, 25, a first driving column, 26, a second driving frame, 27, a second driving column, 28, a clamping ring, 29, a mountain-shaped fixing rod, 30, a fixing disc, 31, a fixing plate, 32 and an extrusion telescopic piece, 33, a stabilizing frame, 34, a buckling limiting piece, 35, a rotating shaft, 36, a buckling piece I, 37, a buckling piece II, 38, a telescopic spring, 39, an upper fixed pipe, 40, a flexible bag part, 41, a lower fixed pipe, 42, a magnetic sealing cover, 43, a connecting rod, 44, a sliding rail type blocking extrusion liquid outlet piece, 45, a track, 46, a magnetic blocking plate, 47, an extrusion rod, 48, an extrusion plate, 49, an alignment telescopic rod I, 50, an alignment telescopic rod II, 51, a fixed block, 52, a bearing block, 53, a concentric alignment piece I, 54, a concentric alignment piece II, 55, a connecting plate I, 56, a limiting rod I, 57, a bidirectional screw I, 58, an alignment rod I, 59, an alignment motor I, 60, a motor fixing piece I, 61, a connecting plate II, 62, a limiting rod II, 63, a bidirectional screw II, 64, an alignment rod II, 65, an alignment motor II, 66, a motor fixing piece II, 67. the device comprises clamping blocks 68, vertical telescopic parts 69, transverse telescopic parts 70, connecting blocks 71, meshing blocks 72, compression studs 73, supporting frames 74, detection platforms 75, height adjusting parts 76 and moving grooves.
The accompanying drawings are included to provide a further understanding of the invention and are incorporated in and constitute a part of this specification, illustrate the invention and together with the embodiments of the invention, serve to explain the invention.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and fully with reference to the accompanying drawings, in which it is evident that the embodiments described are only some, but not all embodiments of the invention; all other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
In the description of the present invention, it should be understood that the terms "upper," "lower," "front," "rear," "left," "right," "top," "bottom," "inner," "outer," and the like indicate orientation or positional relationships based on those shown in the drawings, merely to facilitate description of the invention and simplify the description, and do not indicate or imply that the devices or elements referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus should not be construed as limiting the invention.
As shown in fig. 1 and 2, the invention provides a detection device for immunodiagnosis, which comprises an adjustable fixed bearing detection mechanism 1, a concentric alignment device 2, a reciprocating forward and reverse alternating rotary mixing fixing device 3, a split type mixing dripping device 4 and a detection cartridge fixing component 5, wherein the concentric alignment device 2 is arranged on the adjustable fixed bearing detection mechanism 1, the reciprocating forward and reverse alternating rotary mixing fixing device 3 is arranged on the concentric alignment device 2, the split type mixing dripping device 4 is movably arranged on the reciprocating forward and reverse alternating rotary mixing fixing device 3, and the detection cartridge fixing component 5 is movably arranged on the adjustable fixed bearing detection mechanism 1.
As shown in fig. 1, 2 and 13, the adjustable fixed bearing detection mechanism 1 comprises a support frame 73, a detection platform 74 and a height adjusting member 75, wherein the height adjusting member 75 is arranged on the bottom wall of the support frame 73, and the detection platform 74 is arranged at the movable end of the height adjusting member 75; the detection platform 74 is provided with a moving groove 76, and the engaging block 67 is slidably arranged in the moving groove 76.
As shown in fig. 1, 2 and 12, the detection cartridge fixing assembly 5 includes a clamping block 67, a vertical telescopic member 68, a transverse telescopic member 69, a connecting block 70, a meshing block 71 and a compression stud 72, the clamping block 67 is clamped and slidingly arranged on the adjustable fixed bearing detection mechanism 1, the vertical telescopic member 68 is arranged on the clamping block 67, the connecting block 70 is arranged at the movable end of the vertical telescopic member 68, the transverse telescopic member 69 is arranged on the connecting block 70, the meshing block 71 is arranged at the movable end of the transverse telescopic member 69, the compression stud 72 is rotationally arranged on the meshing block 71, and the bottom end of the compression stud 72 is wrapped with a flexible layer.
As shown in fig. 1, 2 and 11, the concentric alignment device 2 comprises an alignment telescopic rod one 49, an alignment telescopic rod two 50, a fixed block 51, a bearing block 52, a concentric alignment first 53 and a concentric alignment second 54, wherein the alignment telescopic rod one 49 is arranged on the adjustable fixed bearing detection mechanism 1, the alignment telescopic rod two 50 is arranged on the adjustable fixed bearing detection mechanism 1, the alignment telescopic rod one 49 and the alignment telescopic rod two 50 are vertically arranged, the fixed block 51 is respectively arranged at the movable ends of the alignment telescopic rod one 49 and the alignment telescopic rod two 50, the bearing block 52 is arranged on the bottom wall of the fixed block 51, the concentric alignment first 53 is arranged on the bearing block 52, the concentric alignment second 54 is arranged on the bearing block 52, the concentric alignment first 53 and the concentric alignment second 54 are vertically arranged, and the concentric alignment second 54 is arranged below the concentric alignment first 53; the concentric alignment piece I53 comprises a connecting plate I55, a limiting rod I56, a bidirectional screw rod I57, an alignment rod I58, an alignment motor I59 and a motor fixing piece I60, wherein the limiting rod I56 is arranged on the bearing block 52, the connecting plate I55 is arranged at two ends of the limiting rod I56, the bidirectional screw rod I57 is rotationally arranged on the bearing block 52, two ends of the bidirectional screw rod I57 are rotationally arranged on the connecting plate I55, threads with opposite directions are arranged on the bidirectional screw rod I57, the alignment rod I58 is sleeved on the limiting rod I56 and the bidirectional screw rod I57, the alignment rod I58 is rotationally arranged on the limiting rod I56, the alignment rod I58 is meshed with the bidirectional screw rod I57, the motor fixing piece I60 is arranged on the connecting plate I55, the alignment motor I59 is arranged on the motor fixing piece I60, and the output end of the alignment motor I59 is connected with the bidirectional screw rod I57; the concentric alignment part II 54 comprises a connecting plate II 61, a limiting rod II 62, a bidirectional screw rod II 63, an alignment rod II 64, a positive motor II 65 and a motor fixing part II 66, wherein the limiting rod II 62 is arranged on the bearing block 52, the connecting plate II 61 is arranged at two ends of the limiting rod II 62, the bidirectional screw rod II 63 is rotationally arranged on the bearing block 52, two ends of the bidirectional screw rod II 63 are rotationally arranged on the connecting plate II 61, threads with opposite directions are arranged on the bidirectional screw rod II 63, the alignment rod II 64 is sleeved on the limiting rod II 62 and the bidirectional screw rod II 63, the alignment rod II 64 is rotationally arranged on the limiting rod II 62, the alignment rod II 64 is meshed with the bidirectional screw rod II 63 and connected, the motor fixing part II 66 is arranged on the connecting plate II 61, the positive motor II 65 is arranged on the motor fixing part II 66, and the output end of the positive motor II 65 is connected with the bidirectional screw rod II 63.
As shown in fig. 1, fig. 2, fig. 3, fig. 4, fig. 5, fig. 6, fig. 7 and fig. 8, the reciprocating forward and reverse alternating rotary mixing fixing device 3 comprises a forward and reverse mixing disc 6, a rotary clamping piece 7, a fixed sliding frame 8, a reciprocating driving assembly 9, a fixing assembly 10 and a limiting extrusion liquid outlet assembly 11, wherein the fixing assembly 10 is arranged on the concentric alignment device 2, the forward and reverse mixing disc 6 is arranged on the fixing assembly 10, the reciprocating driving assembly 9 is arranged on the fixing assembly 10, the fixed sliding frame 8 is arranged on the fixing assembly 10, the rotary clamping piece 7 is connected with the reciprocating driving assembly 9, the rotary clamping piece 7 is clamped and slidingly arranged in the fixed sliding frame 8, the rotary clamping piece 7 is meshed and connected with the forward and reverse mixing disc 6, and the limiting extrusion liquid outlet assembly 11 is arranged on the bottom wall of the forward and reverse mixing disc 6; the forward and reverse mixing disc 6 comprises a rotary disc body 12, a rotary groove 13, an open convex ring 14, meshing columns 15 and a clamping groove 16, wherein the rotary disc body 12 is connected with the fixed assembly 10 through the clamping groove 16, a magnetic suction ring 17 is arranged on the bottom wall of the rotary disc body 12, the rotary groove 13 is arranged on the rotary disc body 12, the open convex ring 14 is arranged in the rotary groove 13, and the meshing columns 15 are uniformly arranged on the open convex ring 14 at intervals; the rotary clamping piece 7 comprises a clamping column 18, a clamping piece 19 and a clamping sliding block 20, wherein the clamping column 18 is clamped and rotationally arranged in the rotary groove 13, the clamping piece 19 is arranged on the clamping column 18, the clamping piece 19 is meshed with the meshing column 15, and the clamping sliding block 20 is clamped and slidingly arranged in the fixed sliding frame 8; the reciprocating driving assembly 9 comprises a driving motor 21, a first rotating member 22 and a second rotating member 23, wherein the driving motor 21 is arranged on the fixed assembly 10, the first rotating member 22 is connected with the output end of the driving motor 21, and the second rotating member 23 is connected with the first rotating member 22; the first rotating piece 22 comprises a first driving frame 24 and a first driving column 25, the first driving frame 24 is connected with the output end of the driving motor 21, and the first driving column 25 is arranged on the first driving frame 24 in a sliding manner; the second rotating piece 23 comprises a second driving frame 26 and a second driving column 27, the second driving frame 26 is connected with the clamping sliding block 20, the second driving column 27 is in crisscross connection with the first driving column 25, the second driving column 27 is arranged in the second driving frame 26 in a sliding manner, and the first driving frame 24 and the second driving frame 26 are oppositely arranged; the fixing assembly 10 comprises a clamping ring 28, a mountain-shaped fixing rod 29 and a fixing disc 30, the fixing disc 30 is arranged on the concentric alignment device 2, the clamping ring 28 is clamped in the clamping groove 16, and the mountain-shaped fixing rod 29 is respectively connected with the clamping ring 28, the fixing sliding frame 8 and the fixing disc 30; the limiting extrusion liquid outlet assembly 11 comprises a fixed plate 31, an extrusion telescopic piece 32, a stable frame 33 and a buckling limiting piece 34, wherein the fixed plate 31 is arranged on the bottom wall of the turntable body 12, the extrusion telescopic piece 32 is arranged on the fixed plate 31, the stable frame 33 is connected with the movable end of the extrusion telescopic piece 32, and the buckling limiting piece 34 is arranged on the stable frame 33; the buckling limiting piece 34 comprises a rotating shaft 35, a buckling piece I36, a buckling piece II 37 and a telescopic spring 38, the rotating shaft 35 is arranged on the stabilizing frame 33, the buckling piece I36 is rotationally arranged on the rotating shaft 35, the buckling piece II 37 is rotationally arranged on the rotating shaft 35, and the telescopic spring 38 is arranged between the buckling piece I36 and the buckling piece II 37.
As shown in fig. 1, 2, 9 and 10, the split type mixing and dripping device 4 comprises an upper fixed pipe 39, a flexible bag portion 40, a lower fixed pipe 41, a magnetic sealing cover 42, a connecting rod 43 and a sliding rail type sealing extrusion liquid outlet piece 44, wherein the magnetic sealing cover 42 is detachably arranged at the opening of the upper fixed pipe 39, the flexible bag portion 40 is connected with the upper fixed pipe 39, the lower fixed pipe 41 is connected with the flexible bag portion 40, the connecting rod 43 is arranged on the side walls of the upper fixed pipe 39 and the lower fixed pipe 41, and the sliding rail type sealing extrusion liquid outlet piece 44 is arranged at the bottom end of the lower fixed pipe 41; the slide rail type plugging extrusion liquid outlet piece 44 comprises a track 45, a magnetic plugging plate 46, an extrusion rod 47 and an extrusion plate 48, wherein the track 45 is arranged at the bottom end of the lower fixed pipe 41, the magnetic plugging plate 46 is connected with the bottom surface magnetic attraction of the lower fixed pipe 41, the magnetic plugging plate 46 is clamped and slidingly arranged in the track 45, the extrusion rod 47 is connected with the magnetic plugging plate 46, and the extrusion plate 48 is connected with the extrusion rod 47.
In specific use, the magnetic sealing cover 42 is opened, the buffer solution is added into the divided type uniformly-mixing dropping device 4 for weighing, then the sampled sample is added, the magnetic sealing cover 42 is covered again, the magnetic sealing cover 42 is placed into the magnetic suction ring 17 for suction, then the extrusion rod 47 is buckled into the buckling piece I36 and the buckling piece II 37, the driving motor 21 is started, the driving motor 21 rotates to drive the driving frame I24 to rotate, the driving frame I24 rotates to drive the driving column I25 to rotate, meanwhile, the driving column I25 slides along the driving frame I24 to drive the driving column II 27 to rotate, then drive the driving frame II 26 to rotate, meanwhile, the driving column II 27 slides in the driving frame II 26, the driving column frame II rotates to drive the clamping sliding block 20 to rotate, the clamping sliding block 20 rotates to drive the clamping piece 19 to rotate, the clamping piece 19 rotates to drive the clamping column 18 to rotate in the rotating groove 13, the clamping piece 19 rotates to drive the meshing column 15 to rotate, the meshing column 15 rotates to drive the turntable body 12 to rotate, the turntable body 12 rotates to drive the split type mixing dropper 4 to rotate, when the clamping piece 19 rotates to the opening of the opening convex ring 14, the clamping piece 19 drives the clamping sliding block 20 to move along the fixed sliding frame 8 so as to drive the turntable body 12 to rotate reversely, the technical effect of mixing the liquid in forward and reverse directions is achieved, the mixing degree of the liquid is further enhanced, after the mixing is completed, the detection cartridge is placed on the detection platform 74, the position of the detection cartridge is adjusted, the clamping block 67 is moved, the position of the compression stud 72 is adjusted through the expansion and contraction of the vertical expansion piece 68 and the transverse expansion piece 69 so as to adapt to the size of the detection cartridge, after the adjustment is completed, the compression stud 72 is rotated so as to enable the compression stud 72 to move downwards until the flexible layer abuts against the detection cartridge, the technical effect of fixing the position of the detection cartridge is achieved, when sample liquid is dripped, the first detection clamping box moves to cause inaccurate dripping, the first alignment expansion rod 49 is started, the first alignment expansion rod 49 stretches and drives the first concentric alignment member 53 to move, the second alignment expansion rod 50 is started, the second concentric alignment member 54 is driven to move by the second alignment expansion rod 50, the fixing block 51 is enabled to move to the upper part of the sample adding hole of the detection clamping box, the first positive motor 59 is started, the first positive motor 59 rotates to drive the first bidirectional screw 57 to rotate, the first bidirectional screw 57 rotates to drive the first alignment rod 58 to move in opposite directions or back to move until the edge of the first alignment rod 58 is enabled to coincide with the edge of the sample back adding hole, the second positive motor 65 rotates to drive the second bidirectional screw 63 to rotate, the second bidirectional screw 63 rotates to drive the second alignment rod 64 to move in opposite directions or back to until the edge of the second alignment rod 64 coincides with the edge of the sample back adding hole, the first compression rod 49 and the second alignment expansion rod 50 can be adjusted again in the process, the first split-type mixing device can drive the first compression rod 49 to rotate, the first compression rod 58 drives the first compression rod 58 to move in opposite directions or back to move, the second compression plate 47 drives the second compression plate 47 to move, the second compression plate 47 moves to move in opposite directions, the second compression plate 47 drives the second compression plate 47 to move in opposite directions, the opposite direction to the second compression plate 45 moves to the second compression plate 45, the second compression plate 45 moves to the second compression plate 34, the first compression plate 32 moves to the compression plate 32, the compression plate 34 moves to move the compression plate 32, the second compression plate 32 moves to the compression plate 32 is well, the compression plate 32 moves to the lower compression plate 32, and the expansion plate 32 moves the compression plate 33 is well, and the expansion plate 32 moves the expansion plate is well is prevented to move the lower compression plate 34, and the compression plate is well is moved, and the compression plate is moved to move the compression plate 32, and the expansion plate is well is moved to move the compression plate and is made to move the compression plate and is 32, repeating the steps when the medicine is used next time.
It is noted that relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Moreover, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus.
Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
The invention and its embodiments have been described above with no limitation, and the actual construction is not limited to the embodiments of the invention as shown in the drawings. In summary, if one of ordinary skill in the art is informed by this disclosure, a structural manner and an embodiment similar to the technical solution should not be creatively devised without departing from the gist of the present invention.
Claims (3)
1. A detection device for immunodiagnosis, characterized in that: the automatic detection device comprises an adjustable fixed bearing detection mechanism (1), a concentric alignment device (2), a reciprocating forward and reverse alternating rotary mixing fixing device (3), a split type mixing drip device (4) and a detection card box fixing assembly (5), wherein the concentric alignment device (2) is arranged on the adjustable fixed bearing detection mechanism (1), the reciprocating forward and reverse alternating rotary mixing fixing device (3) is arranged on the concentric alignment device (2), the split type mixing drip device (4) is movably arranged on the reciprocating forward and reverse alternating rotary mixing fixing device (3), and the detection card box fixing assembly (5) is movably arranged on the adjustable fixed bearing detection mechanism (1); the reciprocating forward and reverse alternating rotary mixing fixing device (3) comprises a forward and reverse mixing disc (6), a rotary clamping piece (7), a fixed sliding frame (8), a reciprocating driving assembly (9), a fixing assembly (10) and a limiting extrusion liquid outlet assembly (11), wherein the fixing assembly (10) is arranged on the concentric alignment device (2), the forward and reverse mixing disc (6) is arranged on the fixing assembly (10), the reciprocating driving assembly (9) is arranged on the fixing assembly (10), the fixed sliding frame (8) is arranged on the fixing assembly (10), the rotary clamping piece (7) is connected with the reciprocating driving assembly (9), the rotary clamping piece (7) is clamped and slidingly arranged in the fixed sliding frame (8), the rotary clamping piece (7) is meshed and connected with the forward and reverse mixing disc (6), and the limiting extrusion liquid outlet assembly (11) is arranged on the bottom wall of the forward and reverse mixing disc (6). The forward and reverse mixing disc (6) comprises a rotary disc body (12), a rotary groove (13), an open-type convex ring (14), meshing columns (15) and a clamping groove (16), wherein the rotary disc body (12) is connected with a fixed assembly (10) through the clamping groove (16), a magnetic suction ring (17) is arranged on the bottom wall of the rotary disc body (12), the rotary groove (13) is arranged on the rotary disc body (12), the open-type convex ring (14) is arranged in the rotary groove (13), and the meshing columns (15) are uniformly arranged on the open-type convex ring (14) at intervals; the rotary clamping piece (7) comprises a clamping column (18), a clamping piece (19) and a clamping sliding block (20), wherein the clamping column (18) is clamped and rotated in the rotary groove (13), the clamping piece (19) is arranged on the clamping column (18), the clamping piece (19) is meshed with the meshing column (15), and the clamping sliding block (20) is clamped and slidingly arranged in the fixed sliding frame (8); the reciprocating driving assembly (9) comprises a driving motor (21), a first rotating member (22) and a second rotating member (23), wherein the driving motor (21) is arranged on the fixed assembly (10), the first rotating member (22) is connected with the output end of the driving motor (21), and the second rotating member (23) is connected with the first rotating member (22); the first rotating piece (22) comprises a first driving frame (24) and a first driving column (25), the first driving frame (24) is connected with the output end of the driving motor (21), and the first driving column (25) is slidably arranged on the first driving frame (24); the second rotating piece (23) comprises a second driving frame (26) and a second driving column (27), the second driving frame (26) is connected with the clamping sliding block (20), the second driving column (27) is in crisscross connection with the first driving column (25), the second driving column (27) is slidably arranged in the second driving frame (26), and the first driving frame (24) and the second driving frame (26) are oppositely arranged; the fixing assembly (10) comprises a clamping ring (28), a Chinese character 'shan' -shaped fixing rod (29) and a fixing disc (30), wherein the fixing disc (30) is arranged on the concentric alignment device (2), the clamping ring (28) is clamped in the clamping groove (16), and the Chinese character 'shan' -shaped fixing rod (29) is respectively connected with the clamping ring (28), the fixing sliding frame (8) and the fixing disc (30); the limiting extrusion liquid outlet assembly (11) comprises a fixed plate (31), an extrusion telescopic piece (32), a stabilizing frame (33) and a buckling limiting piece (34), wherein the fixed plate (31) is arranged on the bottom wall of the turntable body (12), the extrusion telescopic piece (32) is arranged on the fixed plate (31), the stabilizing frame (33) is connected with the movable end of the extrusion telescopic piece (32), and the buckling limiting piece (34) is arranged on the stabilizing frame (33); the buckling limiting piece (34) comprises a rotating shaft (35), a buckling piece I (36), a buckling piece II (37) and a telescopic spring (38), wherein the rotating shaft (35) is arranged on the stabilizing frame (33), the buckling piece I (36) is rotationally arranged on the rotating shaft (35), the buckling piece II (37) is rotationally arranged on the rotating shaft (35), and the telescopic spring (38) is arranged between the buckling piece I (36) and the buckling piece II (37); the split type mixing drip device (4) comprises an upper fixed pipe (39), a flexible bag part (40), a lower fixed pipe (41), a magnetic sealing cover (42), a connecting rod (43) and a sliding rail type sealing extrusion liquid outlet piece (44), wherein the magnetic sealing cover (42) is detachably arranged at the opening of the upper fixed pipe (39), the flexible bag part (40) is connected with the upper fixed pipe (39), the lower fixed pipe (41) is connected with the flexible bag part (40), the connecting rod (43) is arranged on the side walls of the upper fixed pipe (39) and the lower fixed pipe (41), and the sliding rail type sealing extrusion liquid outlet piece (44) is arranged at the bottom end of the lower fixed pipe (41); the sliding rail type plugging extrusion liquid outlet piece (44) comprises a rail (45), a magnetic plugging plate (46), an extrusion rod (47) and an extrusion plate (48), wherein the rail (45) is arranged at the bottom end of the lower fixed pipe (41), the magnetic plugging plate (46) is magnetically attracted to the bottom surface of the lower fixed pipe (41), the magnetic plugging plate (46) is clamped and slidingly arranged in the rail (45), the extrusion rod (47) is connected with the magnetic plugging plate (46), and the extrusion plate (48) is connected with the extrusion rod (47); the concentric alignment device (2) comprises an alignment telescopic rod I (49), an alignment telescopic rod II (50), a fixed block (51), a bearing block (52), a concentric alignment part I (53) and a concentric alignment part II (54), wherein the alignment telescopic rod I (49) is arranged on the adjustable fixed bearing detection mechanism (1), the alignment telescopic rod II (50) is arranged on the adjustable fixed bearing detection mechanism (1), the alignment telescopic rod I (49) is vertically arranged with the alignment telescopic rod II (50), the fixed block (51) is respectively arranged at the movable ends of the alignment telescopic rod I (49) and the alignment telescopic rod II (50), the bearing block (52) is arranged on the bottom wall of the fixed block (51), the concentric alignment part I (53) is arranged on the bearing block (52), the concentric alignment part II (54) is arranged on the bearing block (52), the concentric alignment part I (53) and the concentric alignment part II (54) are vertically arranged, and the concentric alignment part II (54) is arranged below the concentric alignment part I (53); the concentric alignment piece I (53) comprises a connecting plate I (55), a limiting rod I (56), a bidirectional screw rod I (57), an alignment rod I (58), an alignment rod I (59) and a motor fixing piece I (60), wherein the limiting rod I (56) is arranged on the bearing block (52), the connecting plate I (55) is arranged at two ends of the limiting rod I (56), the bidirectional screw rod I (57) is rotationally arranged on the bearing block (52), two ends of the bidirectional screw rod I (57) are rotationally arranged on the connecting plate I (55), threads with opposite directions are arranged on the bidirectional screw rod I (57), the alignment rod I (58) is sleeved on the limiting rod I (56) and the bidirectional screw rod I (57), the alignment rod I (58) is rotationally arranged on the limiting rod I (56), the alignment rod I (58) is in meshed connection with the bidirectional screw rod I (57), the motor fixing piece I (60) is arranged on the connecting plate I (55), the alignment rod I (59) is arranged on the motor fixing piece I (60), and the alignment rod I (59) is connected with the bidirectional screw rod I (57); the concentric alignment piece II (54) comprises a connecting plate II (61), a limiting rod II (62), a bidirectional screw rod II (63), an alignment rod II (64), an alignment rod II (65) and a motor fixing piece II (66), wherein the limiting rod II (62) is arranged on the bearing block (52), the connecting plate II (61) is arranged at two ends of the limiting rod II (62), the bidirectional screw rod II (63) is rotationally arranged on the bearing block (52), two ends of the bidirectional screw rod II (63) are rotationally arranged on the connecting plate II (61), threads with opposite directions are arranged on the bidirectional screw rod II (63), the alignment rod II (64) is sleeved on the limiting rod II (62) and the bidirectional screw rod II (63), the alignment rod II (64) is rotationally arranged on the limiting rod II (62), the alignment rod II (64) is meshed and connected with the bidirectional screw rod II (63), the motor fixing piece II (66) is arranged on the connecting plate II (61), the alignment rod II (65) is rotationally arranged on the motor fixing piece II (66), and the output end of the alignment rod II (65) is connected with the bidirectional screw rod II.
2. The immunodiagnostic test apparatus of claim 1, wherein: the detection card box fixing assembly (5) comprises a clamping block (67), a vertical telescopic piece (68), a transverse telescopic piece (69), a connecting block (70), a meshing block (71) and a compression stud (72), wherein the clamping block (67) is clamped and slidingly arranged on the adjustable fixed bearing detection mechanism (1), the vertical telescopic piece (68) is arranged on the clamping block (67), the connecting block (70) is arranged at the movable end of the vertical telescopic piece (68), the transverse telescopic piece (69) is arranged on the connecting block (70), the meshing block (71) is arranged at the movable end of the transverse telescopic piece (69), the compression stud (72) is rotationally arranged on the meshing block (71), and the bottom end of the compression stud (72) is wrapped with a flexible layer.
3. The immunodiagnostic test apparatus of claim 2, wherein: the adjustable fixed bearing detection mechanism (1) comprises a supporting frame (73), a detection platform (74) and a height adjusting piece (75), wherein the height adjusting piece (75) is arranged on the bottom wall of the supporting frame (73), and the detection platform (74) is arranged at the movable end of the height adjusting piece (75); the detection platform (74) is provided with a moving groove (76), and the clamping block (67) is clamped and slidingly arranged in the moving groove (76).
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| CN202310215432.3A CN116500249B (en) | 2023-03-08 | 2023-03-08 | Detection device for immunodiagnosis |
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