CN212974935U

CN212974935U - Multistage thermal gradient micro mixer

Info

Publication number: CN212974935U
Application number: CN202020776847.XU
Authority: CN
Inventors: 李军委; 李姗姗; 王子超; 孟冀豫
Original assignee: Hebei University of Technology
Current assignee: Hebei University of Technology
Priority date: 2020-05-12
Filing date: 2020-05-12
Publication date: 2021-04-16
Anticipated expiration: 2030-05-12

Abstract

The utility model relates to a multistage thermal gradient micromixer, PDMS runner board and PDMS heat-conducting plate including the mutual bonding, at least two subchannels have been seted up with the surface of PDMS heat-conducting plate contact on the PDMS runner board, and the subchannel joins and forms the sprue, and the sprue communicates respectively on sprue and the subchannel has first injection through-hole, is equipped with two at least mixed compartments on the sprue, be equipped with two at least sets of heat conduction structures on the PDMS heat-conducting plate with the surface of PDMS runner board contact, the heat conduction structure is located under the mixed compartment.

Description

Multistage thermal gradient micro mixer

Technical Field

The utility model relates to a micro-fluidic technology field especially relates to a multistage thermal gradient micro mixer.

Background

The microfluidic chip is a platform for operating micro-volume fluid on a micron scale, and is an emerging microfluidic device relating to fluid physics, microelectronics, biology and biomedicine.^[1]Liquid in micro flow channelThe small volume and low flow rate of the fluid, when two or more fluids are mixed, the multiple fluids are in a laminar flow state which is difficult to dope each other due to viscosity existing among the fluids, so that the fluids in the micro-channel can be mixed only through intermolecular diffusion, but the action efficiency is very low, and the requirement of the biochemical field on the sufficient and rapid mixing of various reagents cannot be met. Efficient and rapid mixing by means of micromixers is required.

At present, the micromixer mainly includes the active micromixer that exerts the external action and changes the runner structure or increases the passive micromixer of barrier structure in the runner, thereby passive form blender relies on changing the resistance that runner structure increase liquid flows to destroy liquid laminar flow state, but complicated structure greatly reduced the velocity of flow of liquid make the efficiency of mixing also reduce thereupon, consume the test time, complicated runner structure has still increased the degree of difficulty and the cost of chip processing simultaneously. And the passive mixer as a fixed structure cannot control the mixing degree in the experimental process.

A common active micro mixer is mainly a method of mixing based on alternating current and utilizing electric field force, when a liquid environment is placed in an electric field as an electrolyte during a microorganism experiment, cell membranes of microorganisms may be electrically broken down under the action of the electric field, irreparable rupture is generated to damage cell tissues, and microorganisms are inactivated.

SUMMERY OF THE UTILITY MODEL

The utility model aims to solve the technical problem that overcome exist among the prior art not enough, provide a multistage thermal gradient micromixer, utilize the multistage thermal gradient that plus heat conduction metal produced to produce the thermal vortex and promote microfluid and mix, liquid and heat conduction metal direct contact, efficiency is higher, and the mixing distance is short, convenient to use.

The utility model discloses a realize through following technical scheme:

the utility model provides a multistage thermal gradient micromixer, includes bonded PDMS runner board and PDMS heat-conducting plate each other, at least two subchannels have been seted up on the surface of PDMS runner board with PDMS heat-conducting plate contact, and the subchannel converges and forms the sprue, and the sprue is gone up with the subchannel and is communicated respectively and has been filled in the through-hole, is equipped with two at least mixing compartments on the sprue, the surface of PDMS heat-conducting plate with PDMS runner board contact is equipped with two at least sets of heat conduction structures, and the heat conduction structure is located under the mixing compartment.

Furthermore, each group of heat conduction structures comprises four heat conduction grooves, the four heat conduction grooves form a square matrix, each heat conduction groove is at least communicated with two injection runners, each injection runner is communicated with a second injection through hole which penetrates through the injection runner, low-melting-point metal in a melting state is injected into the heat conduction grooves through the injection holes and the injection runners, the cooled and solidified low-melting-point metal forms heat conduction fins, and the second injection through holes are used for cooling and solidifying the low-melting-point metal to form pins.

Furthermore, the main runner is in a straight line shape.

Further, the main runner is S-shaped.

The utility model has the advantages that:

thus, different liquids are injected through the plurality of sub-runners and the first injection through hole, the liquids are mixed through the main runner, the mixed liquids continuously flow forwards through the mixing compartment, wherein low-melting-point metal heat-conducting fins solidified in four heat-conducting grooves of each group of heat-conducting structures are positioned in the same mixing compartment, each heat-conducting fin is respectively arranged at the upper left part, the upper right part, the lower left part and the lower right part of the mixing compartment, the low-melting-point metal solidified in each heat-conducting groove is cooled through the second injection through hole to form pins to be connected with external temperature control equipment, the temperature of the low-melting-point metal heat-conducting fins solidified in each heat-conducting groove is enabled to be the same through the temperature control equipment, two heat-conducting fins on one diagonal line are high in temperature, two heat-conducting fins on the other diagonal line are low in temperature, so that two thermal gradients in opposite directions can be formed in the, the multi-stage thermal gradient generated by the additional heat conducting metal is utilized to generate thermal vortex to promote microfluid mixing, and the liquid is in direct contact with the heat conducting metal, so that the efficiency is higher, the mixing distance is short, and the use is convenient.

Drawings

FIG. 1 is a schematic view of a linear main runner in a PDMS runner plate according to the present invention;

fig. 2 is a schematic top view of the PDMS heat conducting plate of the present invention;

FIG. 3 is a schematic view of the structure of the PDMS flow channel plate in the shape of an S;

FIG. 4 is a top view of the PDMS flow channel plate and the PDMS heat conducting plate in FIG. 1;

FIG. 5 is a top view of the PDMS flow channel plate and the PDMS heat conducting plate in FIG. 3 bonded together;

fig. 6 is a perspective view of a PDMS runner plate perpendicular to a PDMS thermal conductive plate.

In the figure: 1. a PDMS runner plate; 2. a PDMS heat conducting plate; 3. a shunt channel; 4. a main flow channel; 5. a first injection through hole; 6. a mixing compartment; 7. a heat conducting groove; 8. injecting into the flow channel; 9. a second fill via.

Detailed Description

In order to make those skilled in the art better understand the technical solution of the present invention, the present invention will be further described in detail with reference to the accompanying drawings and preferred embodiments.

As shown in the figure, the utility model discloses a PDMS runner board 1 and PDMS heat-conducting plate 2 of inter-bonding, at least two subchannel 3 have been seted up with the surface of PDMS heat-conducting plate 2 contact on the PDMS runner board 1, and subchannel 3 joins and forms sprue 4 that is a font or S-shaped, and the intercommunication has first injection through-hole 5 respectively on sprue 4 and the subchannel 3, is equipped with two at least mixed compartments 6 on the sprue 4, be equipped with two at least sets of heat conduction structures on the PDMS heat-conducting plate 2 with the surface of PDMS runner board 1 contact, the heat conduction structure is located under mixed compartments 6. Every group heat conduction structure package four heat conduction grooves 7, four heat conduction grooves 7 constitute squarely, every heat conduction groove 7 communicates with two at least and pours into runner 8 into, and every pours into runner 8 into the second that runs through and pours into through-hole 9 into, pours into the low melting point metal that melts the state into through filling hole and pouring into runner 8 in the heat conduction groove 7 into, and the low melting point metal that the cooling solidifies forms the conducting strip, and the low melting point metal that the cooling solidifies in the second pours into through-hole 9 forms the pin.

When injecting the low-melting-point metal, firstly buckling the PDMS heat-conducting plate 2 on a flat glass sheet, and when injecting through the second injection hole, enabling the solidified low-melting-point metal and the surface of the PDMS heat-conducting plate 2 to be at the same height without protruding, so as to ensure that the PDMS heat-conducting plate 2 and the PDMS runner plate 1 are mutually abutted and bonded. The low melting point metal may be solder wire.

Thus, different liquids are injected through the plurality of branch channels 3 and the first injection through holes 5, and the liquids are mixed through the main channel 4, wherein the S-shaped linear structure has the advantage of long distance, the long distance increases the flowing time of the fluid, and the mixing degree can be increased;

the mixed liquid continuously flows forwards through the mixing compartment 6, wherein low-melting-point metal heat conducting sheets solidified in four heat conducting grooves 7 of each group of heat conducting structures are all positioned in the same mixing compartment 6, each heat conducting sheet is respectively arranged at the upper left part, the upper right part, the lower left part and the lower right part of the mixing compartment, the low-melting-point metal solidified in the second injection through hole 9 is cooled to form pins to be connected with external temperature control equipment, the temperature of the low-melting-point metal heat conducting sheets solidified in each heat conducting groove 7 is the same through the temperature control equipment, two heat conducting sheets on one diagonal are high in temperature, two heat conducting sheets on the other diagonal are low in temperature, so that two thermal gradients opposite to each other can be formed in the vertical direction to form thermal eddy currents, the fluid is fully mixed under the thermal force, and the thermal eddy currents are generated by utilizing the multi-stage thermal gradients generated by the additional heat conducting metal to promote the, liquid and heat conduction metal direct contact, efficiency is higher, and the mixing distance is short, convenient to use.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, a plurality of modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims

1. A multistage thermal gradient micro-mixer is characterized in that: the PDMS heat conduction plate is provided with at least two sub-channels, the sub-channels are converged to form a main channel, the main channel and the sub-channels are respectively communicated with a first injection through hole, the main channel is provided with at least two mixing compartments, the surface of the PDMS heat conduction plate, which is in contact with the PDMS flow channel plate, is provided with at least two sets of heat conduction structures, and the heat conduction structures are located under the mixing compartments.

2. A multistage thermal gradient micromixer in accordance with claim 1, wherein: each group of heat conduction structures comprises four heat conduction grooves, the four heat conduction grooves form a square matrix, each heat conduction groove is at least communicated with two injection runners, each injection runner is communicated with a second injection through hole which penetrates through the heat conduction groove, low-melting-point metal in a melting state is injected into the heat conduction grooves through the injection holes and the injection runners, the cooled and solidified low-melting-point metal forms heat conduction fins, and the second injection through holes are used for cooling and solidifying the low-melting-point metal to form pins.

3. A multistage thermal gradient micromixer in accordance with claim 1, wherein: the main runner is in a straight line shape.

4. A multistage thermal gradient micromixer in accordance with claim 1, wherein: the main runner is S-shaped.