CN110681298B - 3D laminar flow micromixer - Google Patents

3D laminar flow micromixer Download PDF

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Publication number
CN110681298B
CN110681298B CN201910923003.5A CN201910923003A CN110681298B CN 110681298 B CN110681298 B CN 110681298B CN 201910923003 A CN201910923003 A CN 201910923003A CN 110681298 B CN110681298 B CN 110681298B
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unit
mixing
mixing unit
outlet
lamination
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CN110681298A (en
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程亚
李文博
储蔚
王鹏
齐家
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East China Normal University
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East China Normal University
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30Micromixers
    • B01F33/301Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012Interdigital streams, e.g. lamellae
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/421Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions by moving the components in a convoluted or labyrinthine path
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B01F25/4321Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa the subflows consisting of at least two flat layers which are recombined, e.g. using means having restriction or expansion zones
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/42Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/432Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa
    • B01F25/4321Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa the subflows consisting of at least two flat layers which are recombined, e.g. using means having restriction or expansion zones
    • B01F25/43211Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction with means for dividing the material flow into separate sub-flows and for repositioning and recombining these sub-flows; Cross-mixing, e.g. conducting the outer layer of the material nearer to the axis of the tube or vice-versa the subflows consisting of at least two flat layers which are recombined, e.g. using means having restriction or expansion zones using a simple by-pass for separating and recombining the flow, e.g. by using branches of different length
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/45Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40Static mixers
    • B01F25/45Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads
    • B01F25/452Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces
    • B01F25/4521Mixers in which the materials to be mixed are pressed together through orifices or interstitial spaces, e.g. between beads characterised by elements provided with orifices or interstitial spaces the components being pressed through orifices in elements, e.g. flat plates or cylinders, which obstruct the whole diameter of the tube

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

The invention discloses a 3D laminar flow micromixer, which comprises a V-shaped inlet channel, an outlet channel, and a first mixing unit, a first laminating unit, a second mixing unit, a second laminating unit, a second mixing unit and an exchange unit which are arranged between the inlet channel and the outlet channel and are sequentially connected. The stacking unit twists the upper and lower runners into left and right runners, and the exchanging unit twists the left and right runners to change positions. The configuration of the invention has the advantages that the laminar flow fluid can be efficiently mixed by means of rapid splitting, combination and exchange of the flow channels, the mixing is more efficiently promoted in a Karman vortex street convection mode at a higher flow speed, the structure is simple, the mass preparation is easily carried out by utilizing a laser direct writing mode, and the invention has important application in the fields of drug tests, microchemical reactions and the like.

Description

3D laminar flow micromixer
Technical Field
The invention relates to a micro-mixing device, which is used for obtaining a 3D laminar flow micro-mixer with two fluids uniformly distributed, namely liquid and liquid, liquid and gas, and gas.
Background
Micromixers have become an important component of microfluidic integrated system design; the rapid and uniform mixing is of great significance to microfluidic systems in the fields of chemical synthesis, biochemical analysis, drug delivery, nucleic acid sequencing or synthesis, and the like.
The characteristic dimension of a channel of the microfluidic system is in a micron level, and the Reynolds number is less than 2000, so that fluid mixing is mainly based on a laminar flow mixing mechanism, the influence of molecular diffusion is very obvious, and therefore, the fluid mixing becomes difficult under a certain condition, an expected mixing effect is achieved under the condition of high flux, and a micro mixer needs to be designed.
Disclosure of Invention
The invention aims to provide a 3D laminar flow micromixer which can quickly and efficiently complete the uniform mixing of liquid and liquid, gas and liquid at high flux.
The specific technical scheme for realizing the purpose of the invention is as follows:
a 3D laminar flow micromixer characterized in that it comprises: the device comprises an inlet unit, a first mixing unit, a first laminated unit, a second mixing unit, a second laminated unit, a left-right exchange unit and an outlet unit, wherein the first laminated unit and the second laminated unit have the same structure and are symmetrically arranged relative to a longitudinal section; the first laminated unit, the second mixing unit, the second laminated unit and the left and right exchange units are a plurality of;
a second mixing unit, a first laminating unit, a second mixing unit, a second laminating unit, a second mixing unit and a left and right exchanging unit are sequentially connected to form a unit group;
the inlet unit, the first mixing unit, the first lamination unit, the second mixing unit, the second lamination unit, the second mixing unit, the left-right exchange unit, the first unit group, the second unit group … …, the nth unit group and the outlet unit are sequentially connected to form the 3D laminar flow micromixer; n = 1-6; wherein:
the inlet unit is a V-shaped body, and the two top ends are inlets;
the first mixing unit is a hollow rectangular body, a cylinder is arranged at one third of the length of the first mixing unit in the body and one half of the width of the first mixing unit and is vertical to the bottom surface, and the cylinder is as high as the hollow rectangular body;
the first laminated unit is a cuboid with a rectangular end face formed by twisting ropes through two channels;
the second mixing unit is a hollow rectangular body, two cylinders are symmetrically arranged in the body at a position which is one third away from one end of the length and is vertical to the bottom surface, a position which is one third away from the other end of the length and is one half of the width and a cylinder is arranged at a position which is vertical to the bottom surface, and the cylinder and the hollow rectangular body are equal in height;
the left and right exchange units are double-channel twisted ropes to form a cuboid with a rectangular end face;
the outlet unit is an L-shaped body, and the top end of the outlet unit is an outlet.
The first laminated unit double-channel twisting enables the left and right arrangement channels to be arranged up and down.
The left and right exchange units are double-channel twisted to enable the left and right arrangement channels to be exchanged.
The invention is a standard three-dimensional structure, but the flow direction is a quasi two-dimensional structure, the processing is more convenient, the space occupation ratio can be greatly saved while the extremely high mixing efficiency is provided, and the invention is a micro mixer device with high integration degree and large flux. The structure is easy to radiate, the micro-channel has better radiating function, and if a radiating layer and a temperature control system are added to the outside, some strict temperature control chemical reactions can be carried out; in addition, the structure is a slender rectangular structure, and multi-channel parallel mixing can be integrated, so that large-flux safe pollution-free production can be realized in the chemical industry. When the structure is made small, the efficiency and performance in the aspect of biological monitoring can be greatly improved because of extremely high mixing efficiency.
Drawings
FIG. 1 is a schematic structural view of the present invention;
FIG. 2 is a schematic structural diagram of an embodiment of the present invention;
FIG. 3 is a schematic view of an inlet unit according to the present invention;
FIG. 4 is a schematic structural diagram of a first mixing unit according to the present invention;
FIG. 5 is a schematic view of a first stacked cell structure according to the present invention;
FIG. 6 is a schematic structural diagram of a second mixing unit according to the present invention;
FIG. 7 is a schematic view of a second stacked cell structure according to the present invention;
FIG. 8 is a schematic diagram of the left-right switching unit structure of the present invention;
fig. 9 is a schematic view of the outlet unit structure of the present invention.
Detailed Description
The present invention will be further described with reference to the following examples and drawings, but the scope of the present invention should not be limited thereto.
Referring to fig. 1 and 3-9, the present invention includes: the device comprises an inlet unit 1, a first mixing unit 2, a first laminated unit 3, a second mixing unit 4, a second laminated unit 5, a left-right exchange unit 6 and an outlet unit 7, wherein the first laminated unit 3 and the second laminated unit 5 have the same structure and are symmetrically arranged relative to a longitudinal section; the number of the first laminated unit 3, the second mixing unit 4, the second laminated unit 5 and the left and right exchanging unit 6 is several;
a second mixing unit 4, a first laminating unit 3, a second mixing unit 4, a second laminating unit 5, a second mixing unit 4 and a left and right exchanging unit 6 are sequentially connected to form a unit group;
the inlet unit 1, the first mixing unit 2, the first lamination unit 3, the second mixing unit 4, the second lamination unit 5, the second mixing unit 4, the left and right exchange units 6, the first unit group, the second unit group … …, the nth unit group and the outlet unit 7 are sequentially connected to form the 3D laminar flow micromixer; n = 1-6; wherein:
the inlet unit 1 is a V-shaped body, and two top ends 11 are inlets;
the first mixing unit 2 is a hollow rectangular body, a cylinder 21 is arranged at one third of the length of the first mixing unit in the body and one half of the width of the first mixing unit and is vertical to the bottom surface, and the cylinder 21 is as high as the hollow rectangular body;
the first laminated unit 3 is a cuboid with a rectangular end face formed by double-channel twisted ropes;
the second mixing unit 4 is a hollow rectangular body, two cylinders 42 are symmetrically arranged in the body at a position which is one third away from one end of the length and is vertical to the bottom surface, and a cylinder 41 is arranged at a position which is one third away from the other end of the length and is one half of the width and is vertical to the bottom surface, and the cylinder and the hollow rectangular body are equal in height;
the left and right exchange units 6 are double-channel ropes twisted to form a cuboid with a rectangular end face;
the outlet unit 7 is an L-shaped body, and the top end 71 is an outlet.
The channels 31 and 32 of the first lamination unit 3 are twisted to form the channels 31 and 32 in an up-and-down arrangement.
The left and right exchanging units 6 are provided with the channels 61 and 62 which are twisted to form the left and right arrangement of the channels 61 and 62.
Examples
Referring to fig. 2-9, this embodiment n = 1.
The structure of fig. 2 was processed in quartz glass with a femtosecond laser, and then etched, thereby obtaining the structure of fig. 2 inside the quartz glass.
Referring to fig. 2 and 3, the inlet unit 1 has two circular holes 11 as inlets, which are inlets for two different materials, and two different material convergence forms at the outlet.
Referring to fig. 2 and 4, the first mixing unit 2 is connected to the inlet convergence end, and the first mixing unit 2 is a rectangular mixing channel with a column 21 standing in the middle. Where the dimensions of the cylinder 21 may vary from case to case, the cylinder 21 is used for enhanced mixing for different reynolds indices.
Referring to fig. 2 and 5, the first lamination unit 3 is connected to the mixing unit 2, since the inlet unit 1 is two different material flows a, b, when entering the first lamination unit 3, the material flows a, b uniformly distributed at the left and right are generated at the inlet of the first lamination unit 3, the first lamination unit 3 firstly cuts the material flows a, b uniformly distributed at the left and right into two parts which are the same up and down from the middle, then each part of the upper and lower part runners 31, 32 still maintains the uniform material flows a, b uniformly distributed at the left and right as the material flows forward, the upper runner 31 narrows to the right as the material flows further, the lower runner 32 narrows to the left, the upper runner 31 radially expands downward while narrowing, the lower runner 32 radially expands upward, and finally at the outlet of the first lamination unit 3, the left and right runners with the same size are combined into a complete runner at the outlet, at the moment, the distribution of the interface material flow at the outlet is a, b, and a and b are uniformly distributed in sequence from staggering. The two sub-runners separating the upper part from the lower part adopt a central axis symmetry structure, and the same speed field is ensured. The design of the narrowing, bending and expanding of the first lamination unit 3 ensures that the speed field of the inlet of the lamination unit is consistent with the speed field of the outlet under the condition of laminar flow, thus ensuring that substances transversely layered two layers and uniformly layered at the inlet can form transverse four layers and uniformly layered substance flow at the outlet, and when the substances which are transversely layered two layers and pass through N units in theory without considering mutual diffusion, the substance flow per se can become staggered uniform 2N+1The laminar flow.
Referring to fig. 2 and 6, the second mixing unit 4 is similar to the first mixing unit 2 and is connected with the first laminating unit 3, the second mixing unit 4 is a cuboid mixing channel with three columns standing in the middle, the first column 41 is slightly in front, and the left and right columns 42 are behind the first mixing unit; after lamination, the composite material has certain enhanced mixing effect for different Reynolds indexes.
Referring to fig. 2 and 7, the second laminated unit 5 has the same structure as the first laminated unit 3 and is connected to the second mixing unit 4, and the whole structure of the second laminated unit 5 is a mirror image of the vertical axis of the first laminated unit 3 and is divided into an upper part and a lower part by flow passages 51 and 52; the second layer unit 5 complements the velocity field and the concentration gradient field. When passing through N such cells theoretically without taking into account interdiffusion, the material flow itself of two layers becomes a staggered uniform 2N+1The laminar flow.
Referring to fig. 2 and 8, the left and right exchanging units 6 are connected to the second stacking unit 5, the left and right exchanging units 6 first divide the entire flow path into equal left and right sub-flow paths, and first, the left and right sub-flow paths are separated from the middle of the inlet of the left and right exchanging units 6 into equal left and right sub-flow paths 61, 62, the left sub-flow path 61 contracts to the upper right side and the right sub-flow path 62 contracts to the lower left side as the material flows forward, and after the sub-flow paths contract to the central position, the contraction changes to expansion, and finally the initial left and right sub-flow paths are at the outlet of the left and right exchanging units 6, and the positions of the left and right sub-flow paths are exchanged, so that the material flow at the inlet forms material flow exchanged with the left and right sides at the inlet at the outlet of the flow paths. The whole of the branch flow channel is of a structure symmetrical about the vertical plane of the central axis, and the structural design ensures that the left flow channel and the right flow channel have uniform and same velocity fields after exchange. Because the velocity fields at the left and right boundaries and the center are not uniformly distributed due to the viscosity of the fluid, the velocity at the middle is high, the velocity at the boundary is low, the diffusion at the center of the material flow layering boundary is much faster than that at the boundary under the quasi-steady state condition, and the diffusion of the boundary layer after passing through a plurality of lamination units is far less than that of the central area, so that the invention transfers left and right, enables the high-concentration gradient field and the high-velocity field to be in the middle, fully utilizes the diffusion caused by convection diffusion and the concentration gradient field on a short distance, and further improves the mixing efficiency.
Referring to fig. 2, in the present embodiment, a group of unit sets connected to the left and right exchanging units 6 is provided, that is, the second mixing unit 4, the first stacking unit 3, the second mixing unit 4, the second stacking unit 5, the second mixing unit 4, the left and right exchanging units 6 are connected in sequence, and finally the left and right exchanging units 6 are connected to the outlet unit 7.
Referring to fig. 2 and 9, the outlet unit 7 discharges the mixed fluid through the outlet 71.
The invention can design the number of the unit groups according to the requirement of the specific substance attribute flux, wherein each unit can be freely matched to complete the realization of specific mixing function.

Claims (1)

1. A 3D laminar flow micromixer, characterized in that it comprises: the device comprises an inlet unit (1), a first mixing unit (2), a first lamination unit (3), a second mixing unit (4), a second lamination unit (5), a left-right exchange unit (6) and an outlet unit (7), wherein the first lamination unit (3) and the second lamination unit (5) have the same structure and are symmetrically arranged relative to a longitudinal section; the number of the first laminated units (3), the second mixing units (4), the second laminated units (5) and the left and right exchange units (6) is several;
a second mixing unit (4), a first laminating unit (3), a second mixing unit (4), a second laminating unit (5), a second mixing unit (4) and a left and right exchange unit (6) are sequentially connected to form a unit group;
the inlet unit (1), the first mixing unit (2), the first lamination unit (3), the second mixing unit (4), the second lamination unit (5), the second mixing unit (4), the left and right exchange units (6), the first unit group, the second unit group … …, the nth unit group and the outlet unit (7) are sequentially connected to form the 3D laminar flow micromixer; n = 1-6; wherein:
the inlet unit (1) is a V-shaped body, and the two top ends are inlets;
the first mixing unit (2) is a hollow rectangular body, a cylinder (21) is arranged at one third of the length and one half of the width in the body and is vertical to the bottom surface, and the cylinder (21) is as high as the hollow rectangular body;
the first laminated unit (3) is a cuboid with a rectangular end face formed by twisting ropes through two channels;
the second mixing unit (4) is a hollow rectangular body, two cylinders (42) are symmetrically arranged in the hollow rectangular body at a position which is one third away from one end of the hollow rectangular body and is vertical to the bottom surface, and a cylinder (42) is arranged at a position which is one third away from the other end of the hollow rectangular body and is one half of the width and is vertical to the bottom surface, and the cylinder and the hollow rectangular body are equal in height;
the left and right exchange units (6) are double-channel twisted ropes to form a cuboid with a rectangular end face;
the outlet unit (7) is an L-shaped body, and the top end of the outlet unit is an outlet; wherein the content of the first and second substances,
the first laminated unit (3) is twisted with double channels to change the left and right arrangement channels into up and down arrangement;
the left and right exchange units (6) are in double-channel rope twisting to enable the left and right arrangement channels to be exchanged.
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EP3970841A1 (en) * 2020-09-17 2022-03-23 Sulzer Mixpac AG Static mixer
CN112604616A (en) * 2020-11-17 2021-04-06 华东师范大学 Automatic control system and method for continuous synthesis of microchemical reaction and online monitoring
CN114797527B (en) * 2022-03-28 2023-01-31 徐州华云精细化工有限公司 Feed arrangement is used in surfactant production

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