CN211410691U - Controllable transdermal microneedle intelligent drug delivery device - Google Patents
Controllable transdermal microneedle intelligent drug delivery device Download PDFInfo
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- CN211410691U CN211410691U CN201922422940.0U CN201922422940U CN211410691U CN 211410691 U CN211410691 U CN 211410691U CN 201922422940 U CN201922422940 U CN 201922422940U CN 211410691 U CN211410691 U CN 211410691U
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Abstract
The utility model discloses a controllable transdermal micro-needle intelligent drug delivery device, which comprises a shell; the top of the shell is rotatably connected with a rotary cover, the top of the rotary cover and the bottom of the shell are both provided with flexible substrates, and the lower surface of the flexible substrate at the bottom of the shell is provided with a medical adhesive material layer; at least one storage chamber is arranged in the shell, the top of the storage chamber penetrates through the rotary cover and is connected with the flexible substrate, an automatic baffle is arranged at the bottom of the storage chamber, and the automatic baffle is electrically connected with the sensor and is controlled by the sensor to work; the micro-needle unit is arranged in the shell and located below the storage chamber, and the micro-needle unit is connected with the rotary cover through the rotary lifting device and is controlled to stretch by the rotary cover. The controllable transdermal micro-needle intelligent drug delivery device of the utility model can continuously deliver drug for many times by intelligently controlling the drug delivery dosage, is convenient to use, and can stop drug delivery in time according to specific conditions; in addition, the device is reusable.
Description
Technical Field
The utility model relates to a transdermal technical field that doses, concretely relates to controllable formula transdermal micropin intelligence device of dosing.
Background
The traditional administration modes include oral administration, subcutaneous injection administration, transdermal plaster and the like. Oral administration is simple and convenient, but drug absorption is affected by gastrointestinal functions, and some drugs can cause adverse stimulation to the intestines and stomach. Subcutaneous injection and transdermal patch belong to transdermal administration modes, and transdermal administration is to take skin as an administration route, and deliver the medicament to a vacuum layer or a blood circulation system through the skin, so as to play a role in local or systemic treatment of the skin. The administration mode can effectively avoid first-pass effect, reduce the fluctuation of blood sugar concentration, and has high local treatment targeting property and good patient compliance. The subcutaneous injection mode breaks through the barrier of the horny layer, can accurately and effectively deliver the medicament, but can cause the pain of the human body and even cause the problems of bacterial infection, tissue injury and the like; although the transdermal patch is convenient and painless, the transdermal patch is applied on the skin for administration, so that the drug delivery is limited by the stratum corneum, and the drug absorption effect is poor. In order to solve the above problems, a microneedle technology has been developed, which mainly pierces the stratum corneum of the human body to form a channel beneficial to drug delivery, so as to promote the transdermal absorption of the drug. The microneedle technology has the advantages of no pain, convenient administration and the like, and can avoid gastrointestinal tract digestion and liver first-pass effect. Chinese patent 201720244542.2 discloses an ultra-fine transdermal microneedle, which comprises at least one microneedle array, and a flexible chamber; the channel of the micro needle body is communicated with the flexible chamber. However, the device can only be used for single dose administration and cannot be used for multiple continuous administration. Chinese patent 201821313408.4 discloses an integrated transdermal drug delivery device for drug storage and microneedle, which establishes a drug channel and delivers drug simultaneously, and realizes a continuous multiple drug delivery mode, but it needs manual multiple drug delivery, the operation is cumbersome, and the dosage of drug delivery is uncontrollable.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a controllable transdermal micro-needle intelligent drug delivery device which is used for intelligently controlling the transdermal micro-needle drug delivery; the intelligent control of the administration dosage can continuously and repeatedly administer the medicine, the use is convenient, and a user can timely stop the administration according to specific conditions; in addition, the device is small in size, convenient to carry and reusable.
The technical scheme of the utility model: a controllable transdermal micro-needle intelligent drug delivery device comprises a shell, a drug delivery device and a control device, wherein the shell is provided with an inner cavity; the top of the shell is rotatably connected with a rotary cover, the top of the rotary cover and the bottom of the shell are both provided with flexible substrates, and the lower surface of the flexible substrate at the bottom of the shell is provided with a medical adhesive material layer; at least one storage chamber is arranged in the shell, the top of the storage chamber penetrates through the rotary cover and abuts against the flexible substrate, an automatic baffle is arranged at the bottom of the storage chamber, and the automatic baffle is electrically connected with the sensor and is controlled by the sensor to work; the micro-needle unit is arranged in the shell and located below the storage chamber, and the micro-needle unit is connected with the rotary cover through the rotary lifting device and is controlled to stretch and retract by the rotary cover.
Compared with the prior art, the controllable transdermal microneedle intelligent drug delivery device can intelligently control the drug delivery dosage through the sensor, can continuously deliver the drug for multiple times, can stop the drug delivery in time according to specific conditions, and is simple and convenient to operate; the device is small in size and convenient to carry, the microneedle unit in the device can be stretched through the rotary cover, the microneedle unit is rotated out of the shell when the device is used, and the microneedle unit is rotated back into the shell when the device is not used, so that the microneedle unit can be repeatedly used, and the use cost can be controlled; in addition, the medical adhesive material layer covers the lower surface of the flexible substrate at the bottom of the device, so that the microneedle array can be tightly attached to the skin, the use of a patient during movement is facilitated, and the application range is wider.
Preferably, the microneedle unit comprises a microneedle array consisting of a substrate and at least one microneedle body, and the microneedle array is integrally connected with the upper surface of the substrate.
Preferably, the micro-needle body contains a micro-channel, and the top end of the micro-needle body is provided with an opening. When in use, the medicine can enter the skin of a human body through the micro-channel in the micro-needle body, so that the direct medicine delivery is realized; the utility model discloses in, the speed of dosing can be controlled in the setting of hollow micropin, has further guaranteed accurate drug delivery volume.
As optimization, the length of the micro needle body is 100-700 microns, and the micro needle body can be used for subcutaneous drug injection or subcutaneous blood drawing.
As an optimization, the rotary lifting device comprises a pipe sleeve and a rotating shaft, and the bottom of the pipe sleeve is fixedly connected with the substrate; the top of the rotating shaft is fixedly connected with the spiral cover; the rotating shaft is provided with external threads, and correspondingly, internal threads are arranged inside the pipe sleeve. The rotary lifting device with the structural design adopts a lifting structure similar to lipstick, and the pipe sleeve can be lifted or lowered by rotating the rotary cover, so that the microneedle unit is driven to stretch and retract, and the operation is convenient; and the structure is simple and easy to manufacture.
As optimization, be equipped with a set of fixture block on the circumference of base plate, it is corresponding, the inner wall of casing is equipped with a set of guide way. The fixture block on the base plate is mutually matched with the guide groove on the shell, so that the base plate can be limited to rotate relative to the shell when the screw cap rotates, and therefore the base plate can only do lifting motion along the axial direction of the rotating shaft together with the pipe sleeve, and the microneedle array can conveniently extend out of or retract into the shell.
Preferably, the housing is cylindrical. The cylindrical structure is simple, the manufacture is easy, and the rotation action of the screw cap is convenient.
Drawings
Fig. 1 is a schematic structural diagram of the controllable transdermal microneedle intelligent drug delivery device of the present invention.
The labels in the figures are: 1-shell, 101-guide groove; 2-screwing a cover; 3-a flexible substrate; 4-a layer of medical adhesive material; 5-a storage chamber; 6-automatic baffle; 7-a sensor; 8-substrate, 801-cartridge; 9-micro needle body, 901-micro channel; 10-pipe sleeve; 11-rotating shaft.
Detailed Description
The following description is made with reference to the accompanying drawings and examples, but not to be construed as limiting the invention.
Referring to fig. 1, the controllable transdermal microneedle intelligent drug delivery device of the present invention comprises a housing 1 (the material of the housing 1 can be silicon, metal, organic material or glass), which has an inner cavity; a rotary cover 2 is rotatably connected to the top of the housing 1, a flexible substrate 3 is arranged on both the top of the rotary cover 2 and the bottom of the housing 1 (the flexible substrate 3 can be made of a flexible organic material, such as PDMS silicone material, or other flexible materials, such as polyimide, parylene or silica gel material, etc.), and a medical adhesive material layer 4 is arranged on the lower surface of the flexible substrate 3 on the bottom of the housing 1; at least one storage chamber 5 is arranged in the shell 1 (the size of the storage chamber 5 can be adjusted according to the requirement of the dosage of the medicine and can be selected from 100 microliters to 1000 microliters, the number of the storage chambers 5 can be adjusted according to the type of the medicine to be injected, the storage chambers 5 in the embodiment comprise 4 storage chambers 5, the material of the storage chambers 5 can be silicon, metal, organic material or glass, the top of the storage chamber 5 penetrates through the screw cap 2 (the storage chamber 5 can be embedded in the screw cap 2 to ensure the stability of the storage chamber 5 during the rotation of the screw cap 2) and is abutted against the flexible substrate 3 (the top of the storage chamber 5 can also be directly fixed on the flexible substrate 3, when the medicine is filled into the storage chamber 5, an injector can be used for injecting the medicine into the storage chamber 5 through the flexible substrate 3), the bottom of the storage chamber 5 is provided with an automatic baffle plate 6, and the automatic baffle plate 6 is electrically connected with a sensor 7 (a rotating shaft and the storage chamber 5 and a driving device can be arranged on The motor is connected, the automatic baffle 6 is controlled to rotate relative to the storage chamber 5 through the driving motor, the driving motor is electrically connected with the sensor 7, the sensor 7 can be arranged on the upper surface of the flexible substrate 3 at the top part), and the sensor 7 controls the work; a microneedle unit is arranged in the shell 1 and located below the storage chamber 5, and the microneedle unit is connected with the rotary cover 2 through a rotary lifting device and is controlled to stretch and retract by the rotary cover 2.
As a specific example: the microneedle unit comprises a microneedle array consisting of a substrate 8 and at least one microneedle body 9, and the microneedle array is integrally connected with the upper surface of the substrate 8 (the microneedle array can be directly embedded on the upper surface of the substrate 8, so that the connection firmness between the microneedle array and the substrate is ensured).
As a specific example: the micro-needle body 9 contains a micro-channel 901, and an opening is formed at the top end thereof. When in use, the medicine can enter the skin of a human body through the micro-channel 901 in the micro-needle body 9, so that the direct medicine delivery is realized; the utility model discloses in, the speed of dosing can be controlled in the setting of hollow micropin, has further guaranteed accurate drug delivery volume.
As a specific example: the length of the micro needle body 9 is 100 microns.
As a specific example: the lifting device comprises a pipe sleeve 10 and a rotating shaft 11, and the bottom of the pipe sleeve 10 is fixedly connected with the substrate 8; the top of the rotating shaft 11 is fixedly connected with the spiral cover 2; the rotating shaft 11 is provided with external threads, and correspondingly, the pipe sleeve 10 is internally provided with internal threads. The rotary lifting device with the structural design adopts a lifting structure similar to lipstick, and the pipe sleeve 10 can be lifted or lowered by rotating the rotary cover 2, so that the microneedle unit is driven to stretch and retract, and the operation is convenient; and the structure is simple and easy to manufacture.
As a specific example: a set of fixture blocks 801 is arranged on the circumference of the substrate 8, and correspondingly, a set of guide grooves 101 is arranged on the inner wall of the shell 1. The fixture block 801 on the base plate 8 is matched with the guide groove 101 on the housing 1, so that the rotation of the base plate 8 relative to the housing 1 can be limited when the cap 2 rotates, and therefore, the base plate 8 and the tube sleeve 10 can only do lifting motion along the axial direction of the rotating shaft 11, and the microneedle array can conveniently extend out of or retract into the housing 1.
As a specific example: the housing 1 is cylindrical. The cylindrical structure is simple, easy to manufacture and convenient for the rotation action of the screw cap 2.
The working principle is as follows:
firstly, liquid medicine is filled into each storage chamber 5 in the controllable transdermal microneedle intelligent administration device, and the serial number, the automatic opening and closing time and the timing times of each storage chamber 5 are set in the sensor 7;
secondly, the rotary cover 2 is rotated, the micro-needle unit stretches under the action of the rotary lifting device, so that the micro-needle array penetrates out of the flexible substrate 3 below the rotary cover and enters the skin of a human body, and the medical adhesive material layer 4 at the bottom of the flexible substrate 3 can tightly attach the micro-needle array to the skin;
thirdly, a sensor 7 is touched to open an automatic baffle 6 at the bottom of a set storage chamber 5, so that the liquid medicine in the storage chamber 5 enters a micro needle unit and enters the skin of a human body through a micro channel 901 in a micro needle body 9; after the set time is reached, opening an automatic baffle 6 at the bottom of the next storage chamber 5 to enable the liquid medicine in the next storage chamber 5 to enter the microneedle units, and sequentially administering the medicine according to the number of the storage chambers 5; when the administration is finished, the sensor 7 is stopped and the automatic shutter 6 is closed.
Finally, the screw cap 2 is rotated to rotate the microneedle array back into the housing 1 for the next use.
The present invention relates to the state shown in fig. 1, namely "top", "bottom", "upper surface", "lower surface" and "lower side".
The above general description of the invention and the description of its specific embodiments in this application should not be construed as limiting the scope of the invention. Those skilled in the art can add, reduce or combine the technical features disclosed in the general description and/or the specific embodiments (including the examples) to form other technical solutions within the scope of the present application according to the disclosure of the present application without departing from the components of the present invention.
Claims (7)
1. The utility model provides a controllable formula transdermal micropin intelligence device of dosing which characterized in that: comprises a housing (1) having an internal cavity; the top of the shell (1) is rotatably connected with a rotary cover (2), the top of the rotary cover (2) and the bottom of the shell (1) are both provided with flexible substrates (3), and the lower surface of the flexible substrate (3) at the bottom of the shell (1) is provided with a medical adhesive material layer (4); at least one storage chamber (5) is arranged in the shell (1), the top of the storage chamber (5) penetrates through the rotary cover (2) and abuts against the flexible substrate (3), an automatic baffle (6) is arranged at the bottom of the storage chamber (5), and the automatic baffle (6) is electrically connected with the sensor (7) and is controlled by the sensor (7) to work; be equipped with the micropin unit in casing (1), the micropin unit is located the below of apotheca (5), the micropin unit through rotatory elevating gear with spiral cover (2) link to each other and control its flexible by spiral cover (2).
2. The controllable transdermal microneedle intelligent delivery device of claim 1, wherein: the micro-needle unit comprises a micro-needle array formed by a substrate (8) and at least one micro-needle body (9), and the micro-needle array is integrally connected with the upper surface of the substrate (8).
3. The controllable transdermal microneedle intelligent delivery device of claim 2, wherein: the micro needle body (9) is internally provided with a micro channel (901), and the top end of the micro needle body is provided with an opening.
4. The controllable transdermal microneedle intelligent delivery device of claim 3, wherein: the length of the micro-needle body (9) is 100-700 microns.
5. The controllable transdermal microneedle intelligent delivery device of claim 2, wherein: the lifting device comprises a pipe sleeve (10) and a rotating shaft (11), and the bottom of the pipe sleeve (10) is fixedly connected with the base plate (8); the top of the rotating shaft (11) is fixedly connected with the spiral cover (2); the rotating shaft (11) is provided with external threads, and correspondingly, the pipe sleeve (10) is internally provided with internal threads.
6. The controllable transdermal microneedle intelligent delivery device of claim 2, wherein: the circumference of base plate (8) is equipped with a set of fixture block (801), and correspondingly, the inner wall of casing (1) is equipped with a set of guide way (101).
7. The controllable transdermal microneedle intelligent delivery device according to any one of claims 1 to 6, wherein: the shell (1) is cylindrical.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922422940.0U CN211410691U (en) | 2019-12-27 | 2019-12-27 | Controllable transdermal microneedle intelligent drug delivery device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201922422940.0U CN211410691U (en) | 2019-12-27 | 2019-12-27 | Controllable transdermal microneedle intelligent drug delivery device |
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| CN211410691U true CN211410691U (en) | 2020-09-04 |
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| CN201922422940.0U Active CN211410691U (en) | 2019-12-27 | 2019-12-27 | Controllable transdermal microneedle intelligent drug delivery device |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113499537A (en) * | 2021-09-03 | 2021-10-15 | 河南佳普医药科技有限公司 | Microneedle transdermal delivery device |
| CN114376569A (en) * | 2022-01-19 | 2022-04-22 | 浙江大学 | Glucagon-carrying wearable device for treating hypoglycemia |
-
2019
- 2019-12-27 CN CN201922422940.0U patent/CN211410691U/en active Active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113499537A (en) * | 2021-09-03 | 2021-10-15 | 河南佳普医药科技有限公司 | Microneedle transdermal delivery device |
| CN114376569A (en) * | 2022-01-19 | 2022-04-22 | 浙江大学 | Glucagon-carrying wearable device for treating hypoglycemia |
| CN114376569B (en) * | 2022-01-19 | 2023-10-13 | 浙江大学 | Glucagon-carrying wearable device for treating hypoglycemia |
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