CN113499537A - Microneedle transdermal delivery device - Google Patents
Microneedle transdermal delivery device Download PDFInfo
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- CN113499537A CN113499537A CN202111023413.8A CN202111023413A CN113499537A CN 113499537 A CN113499537 A CN 113499537A CN 202111023413 A CN202111023413 A CN 202111023413A CN 113499537 A CN113499537 A CN 113499537A
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- interlayer
- microneedle
- lower cover
- cover
- retractor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0046—Solid microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Abstract
The invention discloses a microneedle transdermal drug delivery device, which relates to the field of medical instruments, aims to facilitate fixation and observation, is safe and reliable, is used for transdermal drug delivery, and adopts the technical scheme that: the upper cover is provided with an easy-to-tear tape and is connected with a lower cover through a shaft, an easy-to-tear tape is arranged between the upper cover and the lower cover, the left end and the right end of the lower cover are provided with retractors connected through bandages, each retractor is provided with a locking device and a limiting block, the bottom of the lower cover is provided with a microneedle and a cutting device, an upper interlayer and a lower interlayer which are provided with bulges are arranged in the lower cover, the bottoms of the bulges are provided with grooves, the positions of the grooves correspond to the positions of the cutting device, the tops of the grooves and the cutting device are higher than the upper interlayer, and the top of the inner side of the upper cover is provided with a fixing device for connecting the upper interlayer and the lower interlayer; the retractor, the locking device and the bandage are arranged, so that the installation is firmer; a pure mechanical structure is used, so that the device is safer and more reliable; the interlayer is arranged, so that the medicine is sealed and stored and is not easy to deteriorate; the transparent upper cover and the interlayer are arranged, so that direct observation can be realized, and the problem that the medicine is wasted or the device is uncomfortable to a human body after being worn for a long time is avoided.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to a microneedle transdermal delivery device.
Background
The transdermal technology is to utilize the skin as the door of the drug infusion systemic circulation, exert the therapeutic effect of the drug, and is an important breakthrough to the traditional concept of skin medication, the research of the new field is very active at present, a membrane-storage type transdermal drug delivery system, a skeleton controlled release type transdermal drug delivery system, a micro-reservoir controlled release type transdermal drug delivery system and a glue patch controlled release type transdermal drug delivery system are developed successively, and are greatly concerned by the medical world, and the research of the new dosage forms does not relate to the problems of overcoming the obstacle of human skin to the drug dialysis and improving the bioavailability of the drug transdermal absorption, which is also the technical key part of the transdermal drug delivery system, and the problem of poor curative effect of the external medicament through transdermal drug delivery at present.
The administration routes include oral administration, intravenous injection (intravenous injection), intramuscular injection (intramuscular injection), subcutaneous injection (subcutaneous injection), sublingual administration (sublingual), rectal perfusion (rectal administration), eye drop, nasal spray, oral spray (inhalant), and topical (topical) or systemic (transdermal) administration.
Transdermal administration refers to a method of applying or applying a drug to the skin surface, which can be used as systemic administration besides local administration at the affected part of the skin, and in the latter case, the ointment or patch can be placed at the thinner part of the skin, such as the back of the ear, the inner side of the arm, the precordial region, the scrotum, etc., at which time the drug can directly penetrate into the subcutaneous part through the corneal layer of the skin and the accessory structure of the skin, such as the opening of the hair follicle, the sweat gland catheter, etc., and enter into the capillary vessels, and is distributed throughout the body by systemic circulation, the route of administration has the advantages of convenience, simplicity, lasting drug effect, safety, no liver first pass effect, transdermal absorption of certain cardiovascular system drugs, such as the nitroglycerin patch can better prevent the onset of angina after being applied to the precordial region, transdermal administration, the absorbed drug amount is proportional to the area of the drug contacting the skin, the increase of the lipid solubility of the drug can accelerate the transdermal absorption, the skin cuticle can increase the absorption rate of the drug when being wetted, and the drug for transdermal absorption by application is usually prepared into a sustained-release formulation, so that the drug is slowly and stably released to achieve the purpose of exerting the drug effect for a long time.
In medical treatment, the needle and skin must be prepared and strictly sterilized before intravenous injection, usually by inserting a hollow stainless steel long needle into the body to effect drug injection, the drug injection mode can cause patients to feel painful, cause bleeding and even infection when the treatment is improper, particularly cause great pain to the patients who need long-term injection, and the injection operation is mostly carried out by specially trained medical personnel, which not only brings great inconvenience to the patients, but also increases the workload of the medical personnel, in order to overcome the disadvantages of the conventional hollow long needle injection device, transdermal drug delivery systems have been developed in the prior art, i.e., drug is absorbed through the skin at a rate into the systemic circulation via the capillaries, as in 1998, an array of miniature solid silicon needles has been developed by the professor praussninz in the united states for transdermal administration. Yuerefeng et al, the university of Qinghua, also developed transdermal drug delivery systems other than the metal microneedle array flexible patch.
Microneedles of the prior art often present the following problems in use: the fixing is not easy, the rigid micro-needle is difficult to be attached to the skin of a human body, even if the rigid micro-needle is attached to the skin by using an adhesive material, the fixing of the device is affected by sweating and other factors, the rigid micro-needle is easy to fall off, and the human body has certain discomfort; most microneedle drug delivery devices are often additionally provided with circuits or induction devices, and are easy to lose efficacy, so that the drug delivery devices cannot work normally, and meanwhile, drugs are easy to be polluted, so that patients are injured; the medicine is not sealed and stored, so that the medicine is easy to deteriorate; when the medicine is used up, the medicine cannot be observed in the using process, the medicine is easily wasted, or the medicine is attached to the skin for a long time and causes discomfort to the human body.
Disclosure of Invention
In view of the problems in the prior art, the invention discloses a microneedle transdermal drug delivery device which adopts the technical scheme that the device comprises an easy-to-tear tape, an upper cover, a lower cover, an easy-to-tear tape, a retractor, a locking device, a limiting block, a bandage, microneedles, a cutting device, a lower interlayer, an upper interlayer, a bulge and a fixing device, wherein the upper cover is made of transparent materials, the internal structure and the use condition of the drugs can be observed, the drugs can be found in time when used up, the opaque easy-to-tear tape is arranged above the upper cover to prevent the drugs from being influenced by illumination, the microneedle transdermal drug delivery device can be conveniently torn down for use when in use, the lower cover is connected with the lower cover through a lower shaft and can rotate mutually, annular seams are arranged between the outer side surfaces of the upper cover and the lower cover, the easy-to-tear tape is arranged between the annular seams, and the upper end and the lower end of the easy-to-tear tape are respectively connected with the upper cover and the lower cover, the lower part of the left end and the right end of the lower cover is provided with the retractor, the retractor is positively provided with the locking device matched with the retractor, the retractor is convenient to limit the operation of the retractor at any time, the bottom of the retractor is provided with the limiting block, the device can be limited, a space can be reserved at the same time, the bottom of the lower cover is prevented from being touched, the two retractors are connected through the bandage, so that the bandage can be extended or shortened, the device can be conveniently fixed on the skin of a human body, the bottom of the lower cover is arc-shaped and is convenient to match with the skin, the fixing is firmer, and the lower cover is provided with a plurality of microneedles arranged in an array, so that drugs can be uniformly conveyed into the human body, the bottom of the lower cover is also provided with a cavity, the bottom of the cavity is connected with the microneedles, and the top of the cavity is provided with a plurality of through holes, the liquid medicine is delivered into the human body through the micro-needles after entering the cavity through the through holes, so that the liquid medicine flowing down from the upper part can be uniformly delivered, one part of the micro-needles are prevented from discharging the medicine, the other part of the micro-needles do not discharge the medicine, a plurality of cutting devices which are not positioned at the center are arranged at the bottom of the inner side of the lower cover and are used for cutting, the upper interlayer and the lower interlayer are sequentially arranged in the lower cover from top to bottom, the upper interlayer and the lower interlayer are made of transparent flexible materials, the observation is convenient, a high-pressure layer is arranged above the upper interlayer, the internal pressure of the device is increased, the medicine can be delivered into the human body more thoroughly, a medicine layer is arranged above the lower interlayer and is used for treating diseases, the bulges are arranged on the upper interlayer and the lower interlayer, grooves are arranged at the bottoms of the bulges, and correspond to the positions of the cutting devices, the top of the groove and the top of the cutting device are both higher than the upper interlayer, so that the cutting device can cut the interlayer when the upper cover rotates, the top of the inner side of the upper cover is provided with a plurality of fixing devices, and the fixing devices are connected with the upper interlayer and the lower interlayer, so that the cut interlayer is prevented from falling off and further blocking the microneedles.
As a preferable technical scheme of the invention, the side surface of the upper cover is provided with anti-slip lines to prevent the hand from sliding when the upper cover is rotated.
As a preferable technical scheme of the invention, a protection bin is arranged at an outlet of the retractor to prevent impurities such as dust from entering the interior of the retractor.
As a preferable technical scheme, the bottom of the limiting block is arc-shaped, so that the abrasion of the bandage can be reduced, and the skin of a human body can be prevented from being injured by edges and corners.
As a preferred technical scheme of the invention, the bandage is a medical elastic bandage, has good elasticity, is comfortable and is dirty-resistant, and the bandage is provided with a plurality of second through holes, thereby being beneficial to ventilation and perspiration.
In a preferred embodiment of the present invention, the microneedle is a first microneedle or a second microneedle, which can be selected according to actual conditions.
As a preferred technical solution of the present invention, the end of the first microneedle is tapered and is relatively firm, and the end of the second microneedle is tapered and is more sharp.
As a preferable technical scheme of the invention, the length of the extending end of the microneedle is 100-500 μm, and can be selected according to actual conditions.
As a preferable technical scheme of the invention, the radial dimension of the microneedle is 50-100 μm, and can be selected according to actual conditions.
As a preferable technical scheme of the invention, the distribution density of the microneedles is 100-1000/cm, and the microneedles can be selected according to actual conditions.
The invention has the beneficial effects that: according to the invention, the retractor, the locking device and the bandage are arranged, when the device is used, the bandage is firstly stretched, then the retractor is limited by the locking device, then the drug delivery device is placed at a specified position and contacts with the locking device to limit the retractor, and the bandage can automatically fix the device under the action of the retractor, so that the fixing mode is firmer, the device is not influenced by factors such as sweat and the like, and meanwhile, the discomfort of a human body caused by the fact that a viscous material is attached to the skin for a long time is avoided; by removing the circuit or the induction device and using a pure mechanical structure, the device is safer and more reliable, so that the device is not easy to lose efficacy and cannot normally administer the medicine, the pollution of the factors such as circuit damage to the medicine is avoided, and the patient can feel more relieved; the interlayer is arranged, so that the medicine is completely sealed, and the medicine can be stored in a sealed manner and is not easy to deteriorate; through setting up transparent upper cover and interlayer, can carry out direct observation to the structure and the medicine of device inside, can accurately judge whether the medicine is used up, avoided the waste of medicine, also avoided wearing the device for a long time and cause the discomfort to the human body.
Drawings
FIG. 1 is a schematic cross-sectional view of a front view of the present invention;
FIG. 2 is a schematic left side view of the present invention;
FIG. 3 is a schematic top view of the present invention;
fig. 4 is a schematic structural view of a front view of a first microneedle according to the present invention;
fig. 5 is a schematic structural view of a front view of a second microneedle according to the present invention.
In the figure: 1-easy-to-tear sticker, 2-upper cover, 3-lower cover, 4-easy-to-tear tape, 5-retractor, 6-locking device, 7-limiting block, 8-bandage, 9-microneedle, 901-first microneedle, 902-second microneedle, 10-cutting device, 11-lower interlayer, 12-upper interlayer, 13-bulge and 14-fixing device.
Detailed Description
In the description of the present invention, it is to be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are used for simplifying description of the present invention, but do not indicate or imply that the referred device or element must have a specific orientation, be constructed in a specific orientation, and be operated, and thus are not to be construed as limiting the present invention, and furthermore, the terms "first", "second", and "third" are used for descriptive purposes only and are not to be construed as indicating or implying a positive importance.
In the description of the present invention, it should be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; can be mechanically or electrically connected; the two elements can be directly connected or indirectly connected through an intermediate medium, and the two elements can be communicated with each other, so that the specific meaning of the terms in the invention can be understood by those skilled in the art.
Example 1
As shown in figures 1 to 4, the invention discloses a microneedle transdermal drug delivery device, which adopts the technical scheme that the device comprises an easy-to-tear tape 1, an upper cover 2, a lower cover 3, an easy-to-tear tape 4, a retractor 5, a locking device 6, a limiting block 7, a bandage 8, microneedles 9, a cutting device 10, a lower interlayer 11, an upper interlayer 12, a protrusion 13 and a fixing device 14, wherein the upper cover 2 is made of transparent materials and is convenient to observe, the opaque easy-to-tear tape 1 is arranged above the easy-to-tear tape to prevent the drugs from being influenced by illumination, the lower cover 2 is connected with the lower cover through a lower shaft and can rotate mutually, annular seams are arranged between the outer side surfaces of the upper cover 2 and the lower cover 3, the easy-to-tear tape 4 is arranged between the annular seams, the upper end and the lower end of the easy-to-tear tape 4 are respectively connected with the upper cover 2 and the lower cover 3 and can fix the two, the lower parts of the left end and the right end of the lower cover 3 are provided with the retractor 5, the retractor 5 is positively provided with the locking device 6 matched with the retractor, the retractor can be limited, the bottom of the retractor is provided with the limiting block 7, the bottom of the lower cover 3 can be prevented from being touched, the two retractors 5 are connected through the bandage 8 and used for fixing, the bottom of the lower cover 3 is arc-shaped and can be effectively attached to the skin of a human body, the micro needles 9 which are arranged in an array mode are arranged at the bottom of the lower cover 3, medicine can be conveyed evenly, the bottom of the lower cover 3 is further provided with a cavity which can buffer the medicine above the cavity, the medicine can fall evenly, the cavity is connected with the micro needles 9, the top of the cavity is provided with a plurality of through holes, the cutting device 10 which is not located at the center is arranged at the bottom of the inner side of the lower cover 3 and used for cutting, the upper interlayer 12 and the lower interlayer 11 are sequentially arranged in the lower cover 3 from top to bottom, go up interlayer 12 with interlayer 11 is transparent flexible material down, it is equipped with the high-pressure layer to go up interlayer 12 top, interlayer 11 top is equipped with the medicine layer down, forms airtight cavity, guarantees the quality, go up interlayer 12 with be equipped with on interlayer 11 down arch 13, arch 13 bottom is equipped with the recess, the recess with cutting device 10's position is corresponding, the top of recess with cutting device 10's top all is higher than go up interlayer 12 makes cutting device 10 can rip go up interlayer 12 with interlayer 11 down, be equipped with a plurality ofly on the top of 2 inboard upper covers fixing device 14, fixing device 14 connects go up interlayer 11 with interlayer 12 down, prevent to be ripped the interlayer and drop and then block up microneedle 9.
As a preferable technical solution of the present invention, the side surface of the upper cover 2 is provided with an anti-slip pattern, so that the upper cover 2 can be rotated more easily.
As a preferred technical solution of the present invention, a protection cabin is provided at an outlet of the retractor 5, so that it is possible to prevent impurities such as dust from entering through the outlet of the retractor 5 and further affecting its normal operation.
As a preferable technical scheme of the invention, the bottom of the limiting block 7 is arc-shaped, so that the abrasion of the bandage 8 can be reduced, and the skin can be prevented from being injured.
As a preferred technical scheme of the invention, the bandage 8 is a medical elastic bandage which is good in elasticity and cleaner and more sanitary, and the bandage 8 is provided with a plurality of second through holes, so that ventilation and perspiration are facilitated.
As a preferred embodiment of the present invention, the microneedle 9 is a first microneedle 901.
As a preferred embodiment of the present invention, the end of the first microneedle 901 is tapered, and is more rigid.
In a preferred embodiment of the present invention, the length of the extended end of the microneedle 9 is 100 μm, and the microneedle is not easily broken and can enter the superficial skin.
In a preferred embodiment of the present invention, the microneedles 9 have a radial dimension of 50 μm, which facilitates penetration into the human body.
In a preferred embodiment of the present invention, the distribution density of the microneedles 9 is 100 microneedles/cm2The medicine can be smoothly and continuously input into human body.
Example 2
As shown in figures 1, 2, 3 and 5, the invention discloses a micro-needle transdermal drug delivery device, which adopts the technical scheme that the device comprises an easy-to-tear tape 1, an upper cover 2, a lower cover 3, an easy-to-tear tape 4, a retractor 5, a locking device 6, a limiting block 7, a bandage 8, a micro-needle 9, a cutting device 10, a lower interlayer 11, an upper interlayer 12, a bulge 13 and a fixing device 14, wherein the upper cover 2 is made of transparent materials and is convenient to observe, the opaque easy-to-tear tape 1 is arranged above the upper cover to prevent the influence of illumination on drugs, the lower cover 2 is connected with the lower cover 2 through a lower shaft and can rotate mutually, annular seams are arranged between the outer side surfaces of the upper cover 2 and the lower cover 3, the easy-to-tear tape 4 is arranged between the annular seams, the upper end and the lower end of the easy-to-tear tape 4 are respectively connected with the upper cover 2 and the lower cover 3 and are used for fixing the two, the retractor 5 is arranged at the lower parts of the left end and the right end of the lower cover 3, the retractor 5 is positively provided with the locking device 6 matched with the retractor, the retractor 5 can be limited, the limiting block 7 is arranged at the bottom of the retractor, the bottom of the lower cover 3 is prevented from being contacted, the two retractors 5 are connected through the bandage 8 and used for fixing, the bottom of the lower cover 3 is arc-shaped, skin can be better attached, the micro needles 9 arranged in an array are arranged at the bottom of the lower cover 3, medicines can be uniformly conveyed, the bottom of the lower cover 3 is also provided with a cavity, the bottom of the cavity is connected with the micro needles 9, the top of the cavity is provided with a plurality of through holes, the bottom of the inner side of the lower cover 3 is provided with a plurality of cutting devices 10 which are not positioned at the center and used for cutting, the upper interlayer 12 and the lower interlayer 11 are sequentially arranged inside the lower cover 3 from top to bottom, and the upper interlayer 12 and the lower interlayer 11 are both made of transparent flexible materials, convenient to observe, it is equipped with the high-pressure layer to go up interlayer 12 top, 11 tops of interlayer are equipped with the medicine layer down, go up interlayer 12 with be equipped with down on interlayer 11 protruding 13, protruding 13 bottom is equipped with the recess, the recess with cutting device 10's position is corresponding, the top of recess with cutting device 10's top all is higher than go up interlayer 12, make cutting device 10 can rip two interlayers, be equipped with a plurality ofly on the top of 2 inboards on the upper cover fixing device 14, fixing device 14 connects go up interlayer 11 with interlayer 12 down, the interlayer after making the rip can not drop, prevents microneedle 9 is blockked up.
As a preferable technical scheme of the invention, the side surface of the upper cover 2 is provided with anti-slip lines to prevent the hands from sliding.
As a preferable technical solution of the present invention, a protection cabin is provided at an exit of the retractor 5 to prevent the interior of the retractor 5 from being contaminated.
As a preferable technical scheme of the invention, the bottom of the limiting block 7 is arc-shaped, so that the abrasion of the bandage 8 is reduced, and the skin is prevented from being damaged by edges and corners.
As a preferred technical scheme of the invention, the bandage 8 is a medical elastic bandage which is good in elasticity, clean and sanitary, and the bandage 8 is provided with a plurality of second through holes, so that ventilation and perspiration are more convenient.
As a preferred embodiment of the present invention, the second microneedle 902 is used as the microneedle 9.
As a preferred embodiment of the present invention, the end of the second microneedle 902 is wedge-shaped, so as to be more easily punctured into the skin.
In a preferred embodiment of the present invention, the microneedle 9 has an extended end with a length of 500 μm, and can be administered to a deep part of a human body.
In a preferred embodiment of the present invention, the microneedle 9 has a radial dimension of 100 μm, and the drug delivery speed is faster.
In a preferred embodiment of the present invention, the distribution density of the microneedles 9 is 1000 microneedles/cm2The medicine can be rapidly output, and the effect is rapid.
The working principle of the invention is as follows: firstly, selecting a first microneedle 901 or a second microneedle 902, picking a corresponding device after selection is finished, extending a bandage 8 supported by a limiting block 7, then limiting a retractor 5 through a locking device 6, then sleeving the device at a specified position of a human body, then removing the limitation of the locking device 6 on the retractor 5, shortening the bandage 8 under the action of the retractor, fixing the device, enabling the microneedle 9 to enter the human body, tearing off an easy-tearing sticker 1 and an easy-tearing tape 4 after the fixation is finished, then rotating an upper cover 2 to enable the upper cover to rotate relative to a lower cover 3, wherein in the rotating process, a lower interlayer 11 and an upper interlayer 12 are cut by a cutting device 10 positioned in a groove inside a protrusion 13, the cut upper interlayer 12 and the cut lower interlayer 11 are fixed by a fixing device 14, then high-pressure gas and medicine are released, and the medicine can more quickly and thoroughly enter the human body through the microneedle 9 under the push of the high-pressure gas, and the high-pressure gas cannot cause harm to human bodies due to the small volume.
The mechanical connection according to the invention is a conventional means used by the skilled person and can be suggested by limited trials and is common general knowledge.
Components not described in detail herein are prior art.
Although the present invention has been described in detail with reference to the specific embodiments, the present invention is not limited to the above embodiments, and various changes and modifications without inventive changes may be made within the knowledge of those skilled in the art without departing from the spirit of the present invention.
Claims (10)
1. A microneedle transdermal delivery device, comprising: comprises an easy-to-tear tape (1), an upper cover (2), a lower cover (3), an easy-to-tear tape (4), a retractor (5), a locking device (6), a limiting block (7), a bandage (8), a microneedle (9), a cutting device (10), a lower interlayer (11), an upper interlayer (12), a protrusion (13) and a fixing device (14), wherein the upper cover (2) is made of transparent materials, the easy-to-tear tape (1) is opaque and is arranged above the upper cover, the lower cover (2) is connected with a lower shaft, a circular seam is arranged between the upper cover (2) and the outer side surface of the lower cover (3), the easy-to-tear tape (4) is arranged between the circular seams, the upper end and the lower end of the easy-to-tear tape (4) are respectively connected with the upper cover (2) and the lower cover (3), the retractor (5) is arranged at the lower parts of the left end and the right end of the lower cover (3), the retractor (5) is positively provided with the locking device (6) matched with the retractor, the bottom is provided with the limiting block (7), the two retractors (5) are connected with each other through the bandage (8), the bottom of the lower cover (3) is arc-shaped and provided with a plurality of micro needles (9) arranged in an array, the bottom of the lower cover (3) is also provided with a cavity, the micro needles (9) are connected with the bottom of the cavity, the top of the cavity is provided with a plurality of through holes, the bottom of the inner side of the lower cover (3) is provided with a plurality of cutting devices (10) which are not arranged in the center, the inner part of the lower cover (3) is sequentially provided with the upper interlayer (12) and the lower interlayer (11), the upper interlayer (12) and the lower interlayer (11) are both made of transparent flexible materials, a high-pressure layer is arranged above the upper interlayer (12), a drug layer is arranged above the lower interlayer (11), the bulges (13) are arranged on the upper interlayer (12) and the lower interlayer (11), the bottom of the protrusion (13) is provided with a groove, the groove corresponds to the cutting device (10), the top of the groove and the top of the cutting device (10) are both higher than the upper interlayer (12), the top of the inner side of the upper cover (2) is provided with a plurality of fixing devices (14), and the fixing devices (14) are connected with the upper interlayer (11) and the lower interlayer (12).
2. The transdermal microneedle delivery device of claim 1, wherein: the side surface of the upper cover (2) is provided with anti-skid grains.
3. The transdermal microneedle delivery device of claim 1, wherein: and a protection bin is arranged at the outlet of the retractor (5).
4. The transdermal microneedle delivery device of claim 1, wherein: the bottom of the limiting block (7) is arc-shaped.
5. The transdermal microneedle delivery device of claim 1, wherein: medical elastic bandage is selected for use in bandage (8), just be equipped with a plurality of second through-holes on bandage (8).
6. The transdermal microneedle delivery device of claim 1, wherein: the microneedle (9) is a first microneedle (901) or a second microneedle (902).
7. The transdermal microneedle delivery device of claim 6, wherein: the end of the first microneedle (901) is tapered, and the end of the second microneedle (902) is wedge-shaped.
8. The transdermal microneedle delivery device of claim 1, wherein: the length of the extending end of the micro needle (9) is 100-500 mu m.
9. The transdermal microneedle delivery device of claim 1, wherein: the radial size of the micro-needle (9) is 50-100 mu m.
10. The transdermal microneedle delivery device of claim 1, wherein: the distribution density of the micro-needles (9) is 100-1000 roots/cm2。
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| Application Number | Priority Date | Filing Date | Title |
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| CN202111023413.8A CN113499537A (en) | 2021-09-03 | 2021-09-03 | Microneedle transdermal delivery device |
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| CN202111023413.8A CN113499537A (en) | 2021-09-03 | 2021-09-03 | Microneedle transdermal delivery device |
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Citations (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20070250018A1 (en) * | 2004-08-12 | 2007-10-25 | Hirotoshi Adachi | Transdermal Drug Administration System with Microneedles |
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| CN102725019A (en) * | 2010-01-08 | 2012-10-10 | 威斯康星校友研究基金会 | Bladder arrangement for microneedle-based drug delivery device |
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