CN106178245A - A kind of micropin array device for the accurate subcutaneous administration of Wicresoft - Google Patents
A kind of micropin array device for the accurate subcutaneous administration of Wicresoft Download PDFInfo
- Publication number
- CN106178245A CN106178245A CN201610634931.6A CN201610634931A CN106178245A CN 106178245 A CN106178245 A CN 106178245A CN 201610634931 A CN201610634931 A CN 201610634931A CN 106178245 A CN106178245 A CN 106178245A
- Authority
- CN
- China
- Prior art keywords
- syringe
- nut
- needle
- propeller
- micropin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3331—Pressure; Flow
- A61M2205/3334—Measuring or controlling the flow rate
Abstract
The invention discloses a kind of micropin array device for the accurate subcutaneous administration of Wicresoft.The present invention includes syringe pump, flexible pipe and five syringe needle micropins.Syringe pump includes leading screw, fixture, syringe, base, leading screw, nut propeller, screw rod and motor.Leading screw is all connected with motor with one end of screw rod, the other end of leading screw is fixed on base by support after both passing through nut propeller, the other end of screw rod is directly anchored on nut propeller, syringe is fixed in the V-arrangement gathering sill of base by fixture, and the piston of syringe is connected with nut propeller, step motor drive screw rod rotates, rotating of screw rod drives the nut rectilinear movement being meshed therewith, nut promotes nut propeller to move along the guide direction of leading screw, thus pushing syringe piston moves to right, medicinal liquid in syringe is entered in five syringe needle micropins by flexible pipe.Micropin of the present invention thrusts the degree of depth of skin and accurately can control relative to the anglec of rotation of needle cap by controlling micropin nut.
Description
Technical field
The invention belongs to medical instruments field, be specifically related to a kind of micropin array for the accurate subcutaneous administration of Wicresoft and fill
Put.
Background technology
Due to natural skin barrier, the ability extreme difference of the penetrating skin of most drug molecule, macromole hydrophilic
Medicine such as insulins etc. are especially true.Therefore, current most popular Transdermal delivery systems: the administering effect of patche is also paid no attention to
Think.People's applied chemistry penetration enhancer and physics assist two big class means to carry out substantial amounts of work for many years, try hard to overcome
Skin barrier, to strengthen transdermal administration.But all there is different shortcoming in these methods, as easily caused skin allergy, can not effectively promote
Enter macromolecular drug transdermal etc..The acupuncture of traditional disposable single needle hair style is injected always in occupation of the leading side of subcutaneous administration
Formula.But this traditional acupuncture injection has many drawbacks, such as there is strong pain, depth of needling can not regulate, no
Can accurately control injection speed and dosage.
Micropin technology is a kind of to be developed by microelectronic manufacturing technology, combine the micro-of subcutaneous injection and percutaneous plaster advantage
Invasion and attack transdermal administration technology.Micropin refers to a diameter of tens microns, and length acicular texture more than 100 μm, its feature is
Pierce epiderm skin creates a micro scale channel, due to length just through keratodermatitis without regard to relatively deep neural, because of
This pain can reduce even without.Comparing conventional needle subcutaneous delivery system, microneedle device has series of advantages: reduce pain
Bitterly；Can continue by Micropump, accurately be administered；Drug targeting can be discharged into subcutaneous certain depth etc..Micropin percutaneous plaster can
Increase the permeability of medicine, macromolecular drug (such as polypeptide, albumen and vaccine etc.) percutaneous penetration particularly can be made to significantly improve,
Therapeutic effect can be reached.Simplest microneedle patch packaging medicine once discharging on solid array of microneedles, although
It is simple to manufacture, but owing to there is no drug-reservoir and feeding, it is impossible to realize continuous controlled delivery and be administered.Complicated microneedle patch is by micro-
Dynamo-electric manufacture method is integrated drug-reservoir and Micropump on hollow needle row, thus realizes continuous controlled delivery and be administered, but its manufacturing cost
Higher.
The present invention produces micropin array by traditional Shooting Technique on medical composite material.This micropin is circular all
Even distribution, can have 5 to ten several different arrangements, and the length that can be stretched by a rotating mechanism regulation micropin.
This microneedle configuration can be pasted on skin with medical viscose glue easily by two prominent ear lobes of front end, and passes through rear end
Interface access micro-injection syringe or syringe pump, carry out Wicresoft, be accurately administered.
Summary of the invention
It is an object of the invention to for the deficiencies in the prior art, it is provided that a kind of micropin for the accurate subcutaneous administration of Wicresoft arranges
Battle array device.
The technical solution adopted for the present invention to solve the technical problems is as follows:
A kind of micropin array device for the accurate subcutaneous administration of Wicresoft, including syringe pump, flexible pipe and five syringe needle micropins.
Syringe pump includes leading screw, fixture, syringe, base, leading screw, nut propeller, screw rod and motor.Leading screw,
Leading screw is all connected with motor with one end of screw rod, and leading screw, the other end of leading screw pass through to prop up after both passing through nut propeller
Frame is fixed on base, and the other end of screw rod is directly anchored on nut propeller, and syringe is fixed on the V of base by fixture
In shape gathering sill, and the piston of syringe is connected with nut propeller, and step motor drive screw rod rotates, and the rotation of screw rod is driven
The dynamic nut rectilinear movement being meshed therewith, nut promotes nut propeller to move along the guide direction of leading screw, thus promotes
Syringe piston moves to right, and syringe is stepped up in V-arrangement gathering sill by fixture, and the medicinal liquid in syringe enters into five pins by flexible pipe
In head micropin.
Five described syringe needle micropins include needle cap, syringe needle, nut and ear lobe, and nut outer ring is arranged on by draw-in groove with needle cap
Together, the front end of needle cap is provided with two prominent ear lobes, pastes on skin with medical viscose glue；Nut can turn relative to needle cap
Dynamic, nut inner ring is machined with female thread, does relative rotary motion with the external screw thread of syringe needle one end, and nut outer ring only has phase with needle cap
To rotary motion, the most there is not relative motion；Motionless in needle cap, while nut rotates, syringe needle does with needle cap relatively
Along the linear motion of axis direction, thus control microneedles and enter the degree of depth of skin.When syringe needle and needle cap do relative motion, pin
Piston on head slides along needle cap inner chamber, and the conical surface that guides of needle tip coordinates with the inner conical surface of needle cap.Needle wall has ten
Font groove, this groove has the inner chamber along needle axis direction, and the medicinal liquid in syringe enters into the interior of syringe needle by flexible pipe
Chamber, enters back in cross groove, and four terminals of cross recess and the intersection point at center respectively install a micropin, and medicinal liquid passes through
Cross recess enters into the inner chamber of micropin, hence into skin inner layer.Come dosage by controlling the push-in stroke of syringe
Accurately control.
Work process of the present invention is as follows:
The present invention is rotated by step motor drive screw rod, and the nut that screw drive is meshed therewith moves linearly to the right,
Nut promotes nut propeller to move along the guide direction of leading screw, thus pushing syringe piston moves to right, and syringe is by fixture
Stepping up in V-arrangement gathering sill, the medicinal liquid in syringe is entered in five syringe needle micropins by flexible pipe.Micropin is passed through the two of front end
Individual prominent ear lobe is pasted on skin with medical viscose glue, and microneedles pierces through skin surface, and medicinal liquid enters into skin by microneedles
Internal.
The present invention has the beneficial effect that:
The five syringe needle micropins of the present invention are through test of many times amended final structure scheme, and this device can pass through
The output speed controlling motor controls the stroke of syringe piston, thus accurately controls injection speed and dosage.Micropin
The degree of depth thrusting skin accurately can control relative to the anglec of rotation of needle cap by controlling micropin nut.
Accompanying drawing explanation
Fig. 1 is apparatus of the present invention figure；
Fig. 2 (a)-2 (d) is the present invention five syringe needle micropin schematic diagram；
Fig. 3 (a)-3 (c) is the present invention five syringe needle micropin syringe needle schematic diagram；
Fig. 4 (a)-4 (c) is the present invention five syringe needle micropin needle cap schematic diagram；
Fig. 5 (a)-5 (c) is the present invention five syringe needle micropin nut schematic diagram；
In figure: syringe pump 1, leading screw 2, fixture 3, flexible pipe 4, five syringe needle micropin 5, syringe 6, base 7, leading screw 8, nut push away
Enter device 9, screw rod 10, motor 11, needle cap 5-1, inner conical surface 5-1-1, syringe needle 5-2, guide conical surface 5-2-1, groove 5-2-2,
Inner chamber 5-2-3, micropin 5-2-4, nut 5-3, ear lobe 5-4
Detailed description of the invention
The present invention will be further described below in conjunction with the accompanying drawings.
As shown in Figures 1 to 5, a kind of micropin array device for the accurate subcutaneous administration of Wicresoft, including syringe pump 1, soft
Pipe 4 and five syringe needle micropins 5.
Syringe pump 1 includes leading screw 2, fixture 3, syringe 6, base 7, leading screw 8, nut propeller 9, screw rod 10 and stepping electricity
Machine 11.Leading screw 2, leading screw 8 are all connected with motor 11 with one end of screw rod 10, and leading screw 2, the other end of leading screw 8 both pass through
Being fixed on base 7 by support after nut propeller 9, the other end of screw rod 10 is directly anchored on nut propeller 9, injection
Device 6 is fixed in the V-arrangement gathering sill of base 7 by fixture 3, and the piston of syringe is connected with nut propeller 9, stepping electricity
Machine 11 drives screw rod 10 to rotate, and rotating of screw rod 10 drives the nut rectilinear movement being meshed therewith, and nut promotes nut to advance
Device moves along the guide direction of leading screw, thus pushing syringe piston moves to right, and syringe is stepped up at V-arrangement gathering sill by fixture
In, the medicinal liquid in syringe is entered in five syringe needle micropins 5 by flexible pipe.
As shown in Fig. 2 (a)-2 (d), five syringe needle micropins 5 include needle cap 5-1, syringe needle 5-2, nut 5-3 and ear lobe 5-4, spiral shell
Female 5-3 outer ring is installed together by draw-in groove with needle cap 5-1, referring to Fig. 4 (a)-4 (c) and Fig. 5 (a)-5 (c), before needle cap 5-1
End is provided with two prominent ear lobe 5-4, pastes on skin with medical viscose glue；Nut 5-3 can rotate relative to needle cap 5-1, spiral shell
Female 5-3 inner ring is machined with female thread, does relative rotary motion, nut 5-3 outer ring and needle cap 5-with the external screw thread of syringe needle 5-2 one end
1 only has relative rotary motion, and relative motion does not the most occur；As shown in Fig. 3 (a)-3 (c), motionless in needle cap 5-1, nut
While 5-3 rotates, syringe needle 5-2 is relatively and needle cap 5-1 does the linear motion along axis direction, thus controls microneedles and enter
The degree of depth of skin.When syringe needle 5-2 and needle cap 5-1 do relative motion, the piston on syringe needle 5-2 slides along needle cap 5-1 inner chamber, pin
The guiding conical surface 5-2-1 of head 5-2 front end coordinates with the inner conical surface 5-1-1 of needle cap.Cross groove 5-2-2 is had inside syringe needle 5-2,
This groove 5-2-2 has the inner chamber 5-2-3 along syringe needle 5-2 axis direction, and the medicinal liquid in syringe 6 enters into pin by flexible pipe 4
The inner chamber 5-2-3 of head 5-2, enters back in cross groove 5-2-2, and four terminals of cross recess and the intersection point at center are respectively pacified
Filling a micropin 5-2-4, medicinal liquid enters into the inner chamber of micropin by cross recess, hence into skin inner layer.By controlling
Dosage is accurately controlled by the push-in stroke of syringe.
Work process of the present invention is as follows:
The present invention is rotated by step motor drive screw rod, and the nut that screw drive is meshed therewith moves linearly to the right,
Nut promotes nut propeller to move along the guide direction of leading screw, thus pushing syringe piston moves to right, and syringe is by fixture
Stepping up in V-arrangement gathering sill, the medicinal liquid in syringe is entered in five syringe needle micropins by flexible pipe.Micropin is passed through the two of front end
Individual prominent ear lobe is pasted on skin with medical viscose glue, and microneedles pierces through skin surface, and medicinal liquid enters into skin by microneedles
Internal.The five syringe needle micropins of the present invention are through test of many times amended final structure scheme, and this device can be by control
The output speed of motor processed controls the stroke of syringe piston, thus accurately controls injection speed and dosage.Micropin stings
The degree of depth entering skin accurately can control relative to the anglec of rotation of needle cap by controlling micropin nut.
Claims (3)
1., for a micropin array device for the accurate subcutaneous administration of Wicresoft, including syringe pump, flexible pipe and five syringe needle micropins, it is special
Levy and be:
Syringe pump includes fixture, syringe, base, leading screw, nut propeller, screw rod and motor；Leading screw and the one of screw rod
End is all connected with motor, and the other end of two leading screws is fixed on base by support after both passing through nut propeller,
The other end of screw rod is directly anchored on nut propeller, and syringe is fixed in the V-arrangement gathering sill of base by fixture, and note
The piston of emitter is connected with nut propeller, and step motor drive screw rod rotates, and the rotation driving of screw rod is meshed therewith
Nut moves linearly, and nut promotes nut propeller to move along the guide direction of leading screw, thus pushing syringe piston moves to right,
Medicinal liquid in syringe is entered in five syringe needle micropins by flexible pipe.
A kind of micropin array device for the accurate subcutaneous administration of Wicresoft the most according to claim 1, it is characterised in that: institute
The five syringe needle micropins stated include needle cap, syringe needle, nut and ear lobe, and nut outer ring is installed together by draw-in groove with needle cap, needle cap
Front end be provided with two prominent ear lobes, paste on skin with medical viscose glue；Nut can rotate relative to needle cap, nut inner ring
Being machined with female thread, do relative rotary motion with the external screw thread of syringe needle one end, nut outer ring and needle cap only have relative rotary motion,
The most there is not relative motion；Motionless in needle cap, while nut rotates, syringe needle does along axis direction with needle cap relatively
Linear motion, thus control microneedles enter skin the degree of depth；When syringe needle and needle cap do relative motion, the piston edge on syringe needle
Needle cap inner chamber to slide, the conical surface that guides of needle tip coordinates with the inner conical surface of needle cap.
A kind of micropin array device for the accurate subcutaneous administration of Wicresoft the most according to claim 2, it is characterised in that: institute
The needle wall stated has cross groove, and this groove has the inner chamber along needle axis direction, and the medicinal liquid in syringe is by soft
Pipe enters into the inner chamber of syringe needle, enters back in cross groove, and four terminals of cross recess and the intersection point at center are respectively installed
One micropin, medicinal liquid enters into the inner chamber of micropin by cross recess, hence into skin inner layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610634931.6A CN106178245A (en) | 2016-08-04 | 2016-08-04 | A kind of micropin array device for the accurate subcutaneous administration of Wicresoft |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610634931.6A CN106178245A (en) | 2016-08-04 | 2016-08-04 | A kind of micropin array device for the accurate subcutaneous administration of Wicresoft |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106178245A true CN106178245A (en) | 2016-12-07 |
Family
ID=57497096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610634931.6A Pending CN106178245A (en) | 2016-08-04 | 2016-08-04 | A kind of micropin array device for the accurate subcutaneous administration of Wicresoft |
Country Status (1)
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| CN (1) | CN106178245A (en) |
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106806986A (en) * | 2017-03-27 | 2017-06-09 | 深圳市纬安共创生物科技有限公司 | A kind of micropin plantation hand tool of adjustable gear |
| CN106991765A (en) * | 2017-02-24 | 2017-07-28 | 杭州电子科技大学 | A kind of robot portable type intelligently sends part case |
| CN110227203A (en) * | 2019-07-12 | 2019-09-13 | 王彦军 | Subcutaneous microneedle injection device and subcutaneous injection box set |
| WO2021032089A1 (en) * | 2019-08-20 | 2021-02-25 | 贝普医疗科技有限公司 | Visually graduated safe multi-head injection needle |
| WO2021032098A1 (en) * | 2019-08-20 | 2021-02-25 | 贝普医疗科技有限公司 | Multi-head type injection needle |
| WO2021032094A1 (en) * | 2019-08-20 | 2021-02-25 | 贝普医疗科技有限公司 | Safe multi-head injection needle |
| CN113041454A (en) * | 2021-03-23 | 2021-06-29 | 广州可美斯光电科技有限公司 | Radio frequency water light injection instrument |
| CN113134846A (en) * | 2021-03-31 | 2021-07-20 | 杭州电子科技大学 | Modularization software gripper based on micropump drive |
| US11160964B2 (en) * | 2019-06-21 | 2021-11-02 | Microneedles Inc. | Microneedle patch and fabrication device for production of multilayered microneedles |
| CN113842544A (en) * | 2021-10-18 | 2021-12-28 | 中南大学 | Percutaneous permeation-promoting drug delivery device |
| CN116035800A (en) * | 2023-04-03 | 2023-05-02 | 首都医科大学附属北京友谊医院 | Subcutaneous implantation type repeated administration device through semicircular canal inner ear |
| EP3955876A4 (en) * | 2019-04-17 | 2023-05-31 | Path Scientific, LLC | Precision microneedling device and methods of use |
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| CN205252234U (en) * | 2016-01-08 | 2016-05-25 | 中国医科大学附属盛京医院 | 9 point puncture -injection of wicresoft arranges needle |
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| CN103282077A (en) * | 2010-10-28 | 2013-09-04 | 帕纳思有限公司 | Module for use in skin surgery |
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Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106991765A (en) * | 2017-02-24 | 2017-07-28 | 杭州电子科技大学 | A kind of robot portable type intelligently sends part case |
| CN106806986A (en) * | 2017-03-27 | 2017-06-09 | 深圳市纬安共创生物科技有限公司 | A kind of micropin plantation hand tool of adjustable gear |
| CN106806986B (en) * | 2017-03-27 | 2023-12-29 | 深圳市纬安共创生物科技有限公司 | Microneedle planting hand utensil of adjustable gear |
| EP3955876A4 (en) * | 2019-04-17 | 2023-05-31 | Path Scientific, LLC | Precision microneedling device and methods of use |
| US11160964B2 (en) * | 2019-06-21 | 2021-11-02 | Microneedles Inc. | Microneedle patch and fabrication device for production of multilayered microneedles |
| CN110227203A (en) * | 2019-07-12 | 2019-09-13 | 王彦军 | Subcutaneous microneedle injection device and subcutaneous injection box set |
| WO2021032089A1 (en) * | 2019-08-20 | 2021-02-25 | 贝普医疗科技有限公司 | Visually graduated safe multi-head injection needle |
| WO2021032098A1 (en) * | 2019-08-20 | 2021-02-25 | 贝普医疗科技有限公司 | Multi-head type injection needle |
| WO2021032094A1 (en) * | 2019-08-20 | 2021-02-25 | 贝普医疗科技有限公司 | Safe multi-head injection needle |
| CN113041454A (en) * | 2021-03-23 | 2021-06-29 | 广州可美斯光电科技有限公司 | Radio frequency water light injection instrument |
| CN113134846A (en) * | 2021-03-31 | 2021-07-20 | 杭州电子科技大学 | Modularization software gripper based on micropump drive |
| CN113842544A (en) * | 2021-10-18 | 2021-12-28 | 中南大学 | Percutaneous permeation-promoting drug delivery device |
| CN116035800A (en) * | 2023-04-03 | 2023-05-02 | 首都医科大学附属北京友谊医院 | Subcutaneous implantation type repeated administration device through semicircular canal inner ear |
| CN116035800B (en) * | 2023-04-03 | 2023-10-31 | 首都医科大学附属北京友谊医院 | Subcutaneous implantation type repeated administration device through semicircular canal inner ear |
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Application publication date: 20161207 |