CN102553066A - Percutaneous drug delivery system based on porous microneedle structure - Google Patents
Percutaneous drug delivery system based on porous microneedle structure Download PDFInfo
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- CN102553066A CN102553066A CN2011104497255A CN201110449725A CN102553066A CN 102553066 A CN102553066 A CN 102553066A CN 2011104497255 A CN2011104497255 A CN 2011104497255A CN 201110449725 A CN201110449725 A CN 201110449725A CN 102553066 A CN102553066 A CN 102553066A
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- porous
- medicinal liquid
- delivery system
- micropin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
Abstract
The invention discloses a percutaneous drug delivery system based on a porous microneedle structure. The percutaneous drug delivery system comprises a porous microneedle, a polymer film, a pump, a liquid inlet pipe, a liquid outlet pipe, a liquid medicine feeding tank and a liquid medicine storage tank, wherein the polymer film wraps part of the microneedle, so that a tiny part of the needle point and a microneedle base are exposed out of the porous structure; the porous microneedle is connected with the liquid medicine feeding tank, the liquid medicine feeding tank is connected with one end of the liquid outlet pipe, the other end of the liquid outlet pipe is communicated with one end of the liquid inlet pipe in the pump, and the other end of the liquid inlet pipe is connected with the liquid medicine storage tank. The microneedle has a porous structure, therefore, liquid medicine can enter into an organism through multiple channels; and the pump is provided with a power supply and has stable flow. The whole system is simple in structure, easy to make, small in volume and high in efficiency.
Description
Technical field
What the present invention relates to is a kind of device of biomedical sector, in particular a kind of transdermal delivery system based on the porous microneedle configuration.
Background technology
In recent years; Micro-electromechanical system (MEMS) (Micro-Electro-Mechanical Systems) continuous advancement in technology; Making that many micropins that are applied to medical percutaneous dosing are processed comes out; But these micropins still need manually-operated when administration, how to reduce manually-operated and make that administration automatization is a problem demanding prompt solution.Transdermal delivery system generally has two kinds: empty micropin drug-supplying system and solid microneedles drug-supplying system.With respect to the solid microneedles drug-supplying system,, the empty micropin drug-supplying system is easier to realize automatization thereby being beneficial to Sustainable Control.Solid system needs the coating medicine on the needle body surface, needs after having discharged to coat again, is unfavorable for permanent Sustainable Control.Therefore, how developing better empty micropin drug-supplying system is the focus that people pay close attention to.
Fully-integrated empty micropin drug-supplying system does not also have the precedent of application at present; On the one hand because being short of power of drug-supplying system makes that medicinal liquid is difficult to keep forging ahead automatically, on the other hand, the passage of needle body is straight up and down a passage normally; Make that medicinal liquid can only be through the tip release of needle body, efficient is low.
Retrieval through to the prior art document is found; N.Roxhed; People such as B.Samel write articles " Compact, Seamless Integration of Active Dosing andActuation with Microneedles for Transdermal Drug Delivery " (" be used for the quantitative control of percutaneous dosing and drive microneedle device " " the international micro electro mechanical system (MEMS) technology meeting of IEEE ") at IEEEInternational Conference on Micro Electro Mechanical Systems (MEMS) (2006): 414-417.The method of the processing transdermal delivery system of mentioning in this article is to adopt multiple structure to make the microneedle transdermal delivery system, promptly adopts micro-needle array chip and electrons heat chips incorporate to form microneedle device.Inject medicinal liquid from the effusive flow of empty micropin through heating chip with attemperation control.But one side has increased the complexity of technology like this, and on the other hand, the efficient that adds thermal control is low, DeGrain, and also heating causes macromolecular drug to lose efficacy easily.
Summary of the invention
The object of the invention is to overcome the deficiency of prior art; A kind of transdermal delivery system based on the porous microneedle configuration is proposed; Make drives medication power more effectively, lasting, the efficient that medicine gets into organism is higher, medicine is slow through passage diffusion straight up and down, problem such as be short of power to solve; And the present invention to have processing technology simple, more help the characteristics of controlling.
The present invention realizes through following technical scheme:
Transdermal delivery system based on the porous microneedle configuration of the present invention; Comprise: porous micropin, thin polymer film, pump, feed tube, drain pipe, medicinal liquid advance medicine pond, medicinal liquid medicine storage pool; Wherein: thin polymer film wraps a porous micropin part; Make needle point sub-fraction and micropin substrate expose loose structure, the porous micropin enters the medicine pond with medicinal liquid and is connected, and medicinal liquid enters the medicine pond and is connected with drain pipe one end; The drain pipe other end is communicated with in pump with feed tube one end, and the feed tube other end is connected with the medicinal liquid medicine storage pool.
Described porous micropin is that porous material is made, and aperture of each aperture is 1～50 μ m on it.Said aperture can be distributed on all directions of porous micropin.
Described thin polymer film is made for the polymer that adopts good biocompatibility.
Described pump is the miniature peristaltic pump or the miniature piezoelectric pump in charged source.
Described feed tube and drain pipe adopt polytetrafluoroethylmaterial material to be made.
Described medicinal liquid enters the medicine pond and the medicinal liquid medicine storage pool is that flexible polymeric materials is made, and they are respectively that medicinal liquid gets into the accumulator tank of porous micropin and the accumulator tank of original medicinal liquid.
The present invention at first makes feed tube and drain pipe be communicated with in pump; Secondly feed tube connects upward medicine medicine storage pool, and the drain pipe connection is gone up medicinal liquid and advanced medicine pond, good seal; Medicinal liquid enters the medicine pond and connects porous micropin, good seal then.During use, the porous micropin thrusts skin, and pump drives the medicinal liquid medicine storage pool, makes the medicinal liquid of its inside get into drain pipe through feed tube, gets into medicinal liquid by drain pipe then and enters the medicine pond, and the medicinal liquid in the medicine pond gets into organism through the hole in the porous micropin.
Compared with prior art; The present invention adopts the porous micropin to replace empty micropin, makes medicinal liquid to flow out through the hole path diffusion of a plurality of directions on the porous micropin, has increased the passage of medicinal liquid entering organism; And each hole is all very small, makes medicinal liquid flow be easier to control.Adopt the hole of thin polymer film encapsulation micropin surface leakage, good biocompatibility, good airproof performance is practiced thrift medicinal liquid.Adopt the pump driving medicinal liquid outflow medicinal liquid medicine storage pool in charged source to enter the medicine pond with the entering medicinal liquid, the working stability of pump can guarantee operational efficiency.Medicinal liquid enters the medicine pond and the medicinal liquid liquid storage tank is that flexible polymeric materials is made, and is flexible good, is prone to processing.
Description of drawings
Fig. 1 is the structural representation of one embodiment of the invention;
Fig. 2 is the porous micropin sketch map in the embodiment of the invention.
Label among the figure:
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated: present embodiment is that prerequisite is implemented with technical scheme of the present invention, provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
As shown in Figure 1; Present embodiment comprises: hole 4, medicinal liquid on pump 1, porous micropin 2, Parylene (Parylene) 3, the porous micropin 2 advance medicine pond 5, drain pipe 6, medicinal liquid medicine storage pool 7, feed tube 8; Wherein: porous micropin 2 surface parts are encapsulated and enter medicine pond 5 with medicinal liquid by parylene film 3 and are connected; Medicinal liquid enters medicine pond 5 and is connected with an end of drain pipe 6, and drain pipe 6 other ends and feed tube 8 link together in pump 1, and feed tube 8 other ends are connected with medicinal liquid medicine storage pool 7.
As shown in Figure 1, pump 1 is a miniature peristaltic pump, and peristaltic pump drives medicinal liquid and between feed tube 8 and drain pipe 6, flows, and medicinal liquid does not flow through pump housing.Therefore pump be difficult for contaminated, working stability.
In the present embodiment, medicinal liquid enters medicine pond 5 and adopts polydimethylsiloxane (PDMS) casting to form with medicinal liquid medicine storage pool 7, and they are respectively that medicinal liquid gets into the accumulator tank of porous micropin and the accumulator tank of original medicinal liquid.
In the present embodiment, feed tube 8 is made by corrosion resistant polytetrafluoroethylmaterial material with drain pipe 6, and chemical stability is good.
As shown in Figure 2, porous micropin 2 comprises a plurality of apertures 4.Present embodiment selects for use the porous stainless steel Metal Cutting to become little square column, and corrosion obtains rustless steel porous micropin in electrolyte then.
In the present embodiment, all be distributed with aperture 4 on all directions on the rustless steel needle body, it is easier to make that medicinal liquid passes through micropin entering organism.
The operation principle of present embodiment is: when porous micropin 2 thrusts skin; Pump 1 drives medicinal liquid medicine storage pool 7; Make the medicinal liquid of its inside get into drain pipe 6, get into medicinal liquid by drain pipe 6 then and enter medicine pond 5 that the medicinal liquid in medicine pond 5 gets into organism through the hole in the porous micropin 24 through feed tube 8.
In the present embodiment: at first make feed tube 8 and drain pipe 6 be communicated with 1 li of pump; Secondly feed tube 8 connects upward medicine medicine storage pool 7, and drain pipe 6 connections are gone up medicinal liquid and advanced medicine pond 5, good seal; Medicinal liquid enters medicine pond 5 and connects porous micropin 2, good seal then.
Present embodiment can adopt corresponding size according to concrete application requirements.Having listed whole transdermal delivery system size like following table 1 is 3 * 3 * 3cm
3One group of design parameter.
Table 13 * 3 * 3cm
3One group of design parameter of size transdermal delivery system
The passage that the porous micropin of present embodiment can provide multiple confession medicinal liquid to get into organism, efficient is high; Pump housing is difficult for contaminated, working stability, and the transfer efficiency of medicinal liquid is high.
Should be understood that the present invention also has other embodiments except above embodiment, such as materials such as conversion micropin, thin polymer films, adopt other pumps that can realize function among the present invention etc.This is easily on technical foundation disclosed by the invention to those skilled in the art.
Although content of the present invention has been done detailed introduction through above-mentioned preferred embodiment, will be appreciated that above-mentioned description should not be considered to limitation of the present invention.After those skilled in the art have read foregoing, for multiple modification of the present invention with to substitute all will be conspicuous.Therefore, protection scope of the present invention should be limited appended claim.
Claims (7)
1. transdermal delivery system based on the porous microneedle configuration; Comprise: porous micropin, thin polymer film, pump, feed tube, drain pipe, medicinal liquid advance medicine pond and medicinal liquid medicine storage pool; Wherein: thin polymer film wraps a porous micropin part; Make needle point sub-fraction and micropin substrate expose pore structure, the porous micropin enters the medicine pond with medicinal liquid and is connected, and medicinal liquid enters the medicine pond and is connected with an end of drain pipe; The drain pipe other end is communicated with in pump with feed tube, and the other end of feed tube is connected with the medicinal liquid medicine storage pool.
2. the transdermal delivery system based on the porous microneedle configuration according to claim 1 is characterized in that, described porous micropin is that porous material is made, and aperture of each aperture is 1～50 μ m on it.
3. the transdermal delivery system based on the porous microneedle configuration according to claim 2 is characterized in that said aperture is distributed on all directions of porous micropin.
4. the transdermal delivery system based on the porous microneedle configuration according to claim 1 is characterized in that, described thin polymer film is made for the polymer that adopts good biocompatibility.
5. the transdermal delivery system based on the porous microneedle configuration according to claim 1 is characterized in that, described pump is the miniature peristaltic pump or the miniature piezoelectric pump in charged source.
6. the transdermal delivery system based on the porous microneedle configuration according to claim 1 is characterized in that, described feed tube and drain pipe adopt polytetrafluoroethylmaterial material to be made.
7. the transdermal delivery system based on the porous microneedle configuration according to claim 1 is characterized in that, described medicinal liquid enters the medicine pond and the medicinal liquid medicine storage pool adopts flexible polymeric materials to be made.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104117138A (en) * | 2014-07-24 | 2014-10-29 | 河南科技大学 | Ultrasound micro-needle composite transdermal drug delivery device |
| CN104922791A (en) * | 2015-05-26 | 2015-09-23 | 上海交通大学 | Noninvasive acupuncture patch and preparation method thereof |
| CN106178245A (en) * | 2016-08-04 | 2016-12-07 | 杭州电子科技大学 | A kind of micropin array device for the accurate subcutaneous administration of Wicresoft |
| CN106390277A (en) * | 2016-09-28 | 2017-02-15 | 成都市亿泰科技有限公司 | Pressure-controlled flexible microneedle drug delivery system |
| CN107684417A (en) * | 2016-08-04 | 2018-02-13 | 云南科威液态金属谷研发有限公司 | Injecting type microneedle electrodes based on liquid metal fluid channel and preparation method thereof |
| CN114010934A (en) * | 2021-11-29 | 2022-02-08 | 江苏大学 | Local porous silicon micro-needle array and preparation method thereof |
| CN114456334A (en) * | 2021-09-30 | 2022-05-10 | 浙江大学 | Preparation method of porous microneedle, porous microneedle micro-needle and needle array drug delivery system |
| CN115154876A (en) * | 2022-05-24 | 2022-10-11 | 北京化工大学 | Ear-shaped bionic porous microneedle transdermal drug delivery system |
| WO2023009073A3 (en) * | 2021-07-30 | 2023-04-27 | Nusmetics Pte. Ltd. | A microneedle apparatus |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT201700048421A1 (en) * | 2017-05-04 | 2018-11-04 | Materias S R L | DEVICE FOR THE TRANSDERMIC ADMINISTRATION OF ACTIVE MOLECULES, USES OF SUCH A DEVICE AND METHODS OF PRODUCTION OF SUCH A DEVICE AND OF ITS COMPONENTS |
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| CN1310755A (en) * | 1998-07-22 | 2001-08-29 | 英国国防部 | Transferring materials into cells using porous silicon |
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Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104117138A (en) * | 2014-07-24 | 2014-10-29 | 河南科技大学 | Ultrasound micro-needle composite transdermal drug delivery device |
| CN104922791A (en) * | 2015-05-26 | 2015-09-23 | 上海交通大学 | Noninvasive acupuncture patch and preparation method thereof |
| CN106178245A (en) * | 2016-08-04 | 2016-12-07 | 杭州电子科技大学 | A kind of micropin array device for the accurate subcutaneous administration of Wicresoft |
| CN107684417A (en) * | 2016-08-04 | 2018-02-13 | 云南科威液态金属谷研发有限公司 | Injecting type microneedle electrodes based on liquid metal fluid channel and preparation method thereof |
| CN107684417B (en) * | 2016-08-04 | 2020-07-07 | 云南科威液态金属谷研发有限公司 | Injection type microneedle electrode based on liquid metal micro-channel and preparation method thereof |
| CN106390277A (en) * | 2016-09-28 | 2017-02-15 | 成都市亿泰科技有限公司 | Pressure-controlled flexible microneedle drug delivery system |
| WO2023009073A3 (en) * | 2021-07-30 | 2023-04-27 | Nusmetics Pte. Ltd. | A microneedle apparatus |
| CN114456334A (en) * | 2021-09-30 | 2022-05-10 | 浙江大学 | Preparation method of porous microneedle, porous microneedle micro-needle and needle array drug delivery system |
| CN114010934A (en) * | 2021-11-29 | 2022-02-08 | 江苏大学 | Local porous silicon micro-needle array and preparation method thereof |
| CN114010934B (en) * | 2021-11-29 | 2024-03-19 | 江苏大学 | Local porous silicon microneedle array and preparation method thereof |
| CN115154876A (en) * | 2022-05-24 | 2022-10-11 | 北京化工大学 | Ear-shaped bionic porous microneedle transdermal drug delivery system |
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| CN102553066B (en) | 2013-07-17 |
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