CN116035800B - Subcutaneous implantation type repeated administration device through semicircular canal inner ear - Google Patents
Subcutaneous implantation type repeated administration device through semicircular canal inner ear Download PDFInfo
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- CN116035800B CN116035800B CN202310342881.4A CN202310342881A CN116035800B CN 116035800 B CN116035800 B CN 116035800B CN 202310342881 A CN202310342881 A CN 202310342881A CN 116035800 B CN116035800 B CN 116035800B
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- delivery device
- administration
- semicircular canal
- catheter
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- 210000002480 semicircular canal Anatomy 0.000 title claims abstract description 72
- 210000003027 ear inner Anatomy 0.000 title claims abstract description 35
- 238000007920 subcutaneous administration Methods 0.000 title claims abstract description 13
- 238000002513 implantation Methods 0.000 title claims description 6
- 238000012377 drug delivery Methods 0.000 claims abstract description 105
- 239000003814 drug Substances 0.000 claims abstract description 73
- 229940079593 drug Drugs 0.000 claims abstract description 30
- 230000005540 biological transmission Effects 0.000 claims abstract description 11
- 210000001595 mastoid Anatomy 0.000 claims abstract description 7
- 208000017119 Labyrinth disease Diseases 0.000 claims abstract description 6
- 229940126585 therapeutic drug Drugs 0.000 claims abstract description 4
- 238000002347 injection Methods 0.000 claims description 56
- 239000007924 injection Substances 0.000 claims description 56
- 239000003708 ampul Substances 0.000 claims description 12
- 239000007779 soft material Substances 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 6
- 210000000988 bone and bone Anatomy 0.000 claims description 5
- 238000003780 insertion Methods 0.000 claims description 5
- 230000037431 insertion Effects 0.000 claims description 5
- 238000001415 gene therapy Methods 0.000 claims description 3
- 238000001802 infusion Methods 0.000 claims description 3
- 238000009168 stem cell therapy Methods 0.000 claims description 3
- 238000009580 stem-cell therapy Methods 0.000 claims description 3
- 230000000638 stimulation Effects 0.000 claims description 3
- 230000008685 targeting Effects 0.000 claims description 3
- 238000002560 therapeutic procedure Methods 0.000 claims description 3
- 238000010009 beating Methods 0.000 claims 3
- 230000001105 regulatory effect Effects 0.000 claims 1
- 230000000149 penetrating effect Effects 0.000 abstract 1
- 239000012530 fluid Substances 0.000 description 10
- 210000003060 endolymph Anatomy 0.000 description 8
- 210000004049 perilymph Anatomy 0.000 description 6
- 238000005507 spraying Methods 0.000 description 6
- 210000000959 ear middle Anatomy 0.000 description 5
- 239000007788 liquid Substances 0.000 description 4
- 210000003477 cochlea Anatomy 0.000 description 3
- 238000001990 intravenous administration Methods 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 238000001647 drug administration Methods 0.000 description 2
- 210000002388 eustachian tube Anatomy 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000005077 saccule Anatomy 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
- 229910002027 silica gel Inorganic materials 0.000 description 2
- 206010011878 Deafness Diseases 0.000 description 1
- 206010020772 Hypertension Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000009205 Tinnitus Diseases 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 231100000895 deafness Toxicity 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 210000002768 hair cell Anatomy 0.000 description 1
- 208000016354 hearing loss disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 231100000886 tinnitus Toxicity 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F11/00—Methods or devices for treatment of the ears or hearing sense; Non-electric hearing aids; Methods or devices for enabling ear patients to achieve auditory perception through physiological senses other than hearing sense; Protective devices for the ears, carried on the body or in the hand
- A61F11/20—Ear surgery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0662—Ears
Abstract
The invention relates to a subcutaneous implanted type semi-structured inner ear repeated administration device, which comprises the following components: the drug delivery device is used for accurately pushing the micro drug delivery device to accurately deliver drugs and comprises a drug delivery device shell and a transmission structure, wherein the transmission structure is arranged inside the drug delivery device shell; a micro-drug delivery device for sucking therapeutic drugs and delivering the drugs out, and injecting the drugs into the skin of a patient; a drug delivery device; the medicine feeding device comprises a medicine feeding base and a medicine feeding guide pipe, wherein the medicine feeding base is buried in the ear of a patient, the medicine feeding guide pipe is arranged in the mastoid process of the patient, the tail end of the medicine feeding guide pipe is inserted into a semicircular canal, the medicine feeding guide pipe is fixedly connected with the medicine feeding base, and the medicine feeding guide pipe is communicated with the inside of the medicine feeding base; the micro drug delivery device is detachably connected with the drug delivery device, and the micro drug delivery device can be connected with the inside of the catheter penetrating into the drug delivery base to deliver drugs to the inside of the drug delivery base, so that the inner ear diseases can be treated.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to a subcutaneous implanted type device for repeatedly administering medicines through the inner ear of a semicircular canal.
Background
The inner ear is also called the labyrinth, which comprises a semicircular canal (an outer semicircular canal, a front semicircular canal and a rear semicircular canal), a vestibule and a cochlea, wherein a membranous structure of the labyrinth is divided into two parts, the outer side of the membranous structure is a gap between a bone substance and the membranous structure,
the internal part of the membranous structure is the membranous labyrinth, which is filled with endolymph, and the volume of the endolymph is about 34 microliters. The receptors of the inner ear are located in the membranous labyrinth, and the microenvironment surrounding it is endolymph. The inner ear receptors include the ampulla and the saccules in the semicircular canal, the elliptical sacs and saccules in the vestibule, the hair cells in the cochlea, and the inner ear receptors mainly feel linear and angular acceleration, gravity and sound. Lesions and injuries of the inner ear can cause dizziness, tinnitus and deafness, and as no effective inner ear administration route and administration device are available, the treatment is clinically carried out by adopting oral administration, intravenous administration and middle ear administration, and due to side effects of medicines, the dosage of oral administration and intravenous administration is often difficult to reach the effective inner ear medicine concentration, and patients with basic diseases (hypertension, diabetes, nephropathy and the like) are more limited by oral administration and intravenous administration. Although the middle ear administration can achieve the aim of local administration, since the middle ear cavity and the nasopharynx part are communicated through the eustachian tube, the liquid medicine always flows out of the middle ear cavity through the eustachian tube rapidly, the middle ear administration needs to permeate through the round window membrane, the permeated liquid medicine only can reach the perilymph fluid of the inner ear, but the inner ear receptor is positioned in the perilymph fluid, and therefore, the liquid medicine also needs to cross the barrier of membranous structure between the perilymph fluid and the endolymph fluid, and the effective medicine concentration in the endolymph fluid is difficult to reach. At present, the artificial cochlea electrode can be implanted through the round window, and the inner ear administration is realized through the electrode side hole, but the administration also releases the liquid medicine into the perilymph fluid, and the aim of administration is mainly to reduce the inner ear inflammatory reaction caused by the electrode implantation, and the like. With the development of biomedical technology, gene therapy, stem cell therapy and biological targeting therapy will be more applied to inner ear diseases, and development of a safe, effective and repeatable inner ear drug delivery device is urgently needed.
The present invention addresses the above-described problems by providing a subcutaneously implantable device for repeated administration of drugs through the inner ear of a semicircular canal.
Disclosure of Invention
In order to overcome the problems in the background art, the invention adopts the following technical scheme:
a subcutaneously implantable semi-structured inner ear repeat dosing device comprising:
the drug delivery device is used for accurately pushing the micro drug delivery device to accurately deliver drugs; the drug delivery device comprises a drug delivery device shell and a transmission structure, wherein the transmission structure is arranged inside the drug delivery device shell;
a micro-drug delivery device for sucking therapeutic drug and delivering the drug out, and delivering the drug into subcutaneous drug delivery device of patient; the medicine is used for gene therapy, stem cell therapy or biological targeting therapy;
a drug delivery device; the ear-implanted dosing device comprises a dosing base and a dosing catheter, wherein the dosing catheter is arranged inside the ear of a patient after the dosing base is implanted in the ear of the patient, the tail end of the dosing catheter is inserted into a semicircular canal, the dosing catheter is fixedly connected with the dosing base, and the dosing catheter is communicated with the inside of the dosing base;
the micro-drug delivery device is detachably connected with the drug delivery device, and can be connected with a catheter to be pricked into the drug delivery base to deliver drugs to the drug delivery base, so that inner ear diseases can be treated.
Further, the transmission structure comprises a driving motor, a screw rod, a fixed plate and a moving block; the fixed block comprises a first fixed block and a second fixed block; the driving motor is fixedly connected with the screw rod, the fixing plates are arranged on two sides of the screw rod, the screw rod is rotationally connected with the fixing plates, the moving block is arranged between the first fixing plate and the second fixing plate, and the moving block is movably connected with the screw rod.
Further, the bottom of the driving motor is provided with a mounting plate, at least two fixing holes are formed in the mounting plate, the driving motor is fixed on the inner side of the bottom of the casing of the drug delivery device, and holes matched with the fixing holes are formed in the inner side of the bottom of the casing of the drug delivery device.
Further, the length of the screw is greater than the distance between the first fixed block and the second fixed block.
Further, the through holes are formed in the centers of the first fixing block and the second fixing block, the diameter of each through hole is larger than that of the corresponding lead screw, bearings are arranged in the through holes, the lead screw is mounted on the bearings, and the second end of the lead screw extends out of the through hole of the second fixing block and is fixedly connected with the driving motor.
Further, at least one polish rod is arranged between the first fixed block and the second fixed block; optionally, two polish rods are arranged between the first fixed block and the second fixed block.
Further, a threaded hole is formed in the center of the moving block, the threaded hole is matched with threads on the screw rod, and a through hole matched with the polish rod is formed in the moving block; the moving block is arranged between the first fixed block and the second fixed block, the screw rod passes through the threaded hole, and the polished rod passes through the through hole; the arrangement ensures that the moving block can move between the first fixed block and the second fixed block when the screw rotates.
Further, a connecting rod is arranged on one side, close to the front side face of the shell of the drug delivery device, of the moving block, a drug spraying block is arranged at the rear end of the connecting rod, a T-shaped groove is formed in the side face of the drug spraying block, and the T-shaped groove penetrates through the drug spraying block.
Further, a groove-shaped through hole is formed in the front side face of the drug delivery device shell, and the length of the groove-shaped through hole is the same as that of the movement range of the moving block.
Further, an arc-shaped groove is formed in the side face of the groove-shaped through hole in the front side face of the drug delivery device shell, the radian of the arc-shaped groove is 120-180 degrees, a circular groove is formed in the joint of the arc-shaped groove and the groove-shaped through hole, and the circular groove is perpendicular to the front side face of the drug delivery device shell; optionally, the arc of the arcuate groove is set to 180 degrees.
Further, a clamping structure is arranged at the lower side of the arc-shaped groove of the drug delivery device shell, and the clamping structure comprises a cylindrical rod and a clamping block; the clamping block is in a strip shape, a round hole is formed in any side of the clamping block, the clamping block is arranged on the cylindrical rod, and the clamping block can rotate along the cylindrical rod; friction force is arranged between the clamping block and the cylindrical rod, and relative rotation can not occur during non-manual operation.
Further, a display screen is arranged on the upper portion of the front side face of the drug delivery device shell, a switch and at least two adjusting buttons are arranged on any side of the display screen, and the adjusting buttons can adjust the drug delivery quantity and the drug delivery speed of the micro drug delivery device.
Furthermore, a control system is arranged in the shell of the drug delivery device, the rotating speed and the rotating time of the driving motor can be controlled, and the control system is selected from the prior art.
Further, a power line is arranged at the rear end of the drug delivery device shell and can supply power for all components.
Further, the micro-drug delivery device comprises a syringe, an injection part and a syringe; the injection device is characterized in that the inside of the injection tube is hollow, the injection part is configured inside the injection tube and is movably connected with the injection tube, the injection tube is arranged at the front end of the injection tube, and the injection tube is detachably connected with the injection tube. The syringe has an internal volume of 30-50 microliters and the inner ear receptors are immersed in the endolymph fluid, which is approximately 34 microliters in total.
Further, the injection port is arranged at the front end of the injection tube, the hand-held part is arranged at the rear end of the injection tube, the hand-held part can be placed in the circular groove, the middle part of the injection tube can be placed in the arc groove, and the injection tube can be fixed by the clamping structure, so that the injection tube is prevented from falling out of the arc groove when the injection tube is used for injecting medicines.
Further, the injection part comprises a piston, a connecting rod and a pressing part, wherein the first end of the connecting rod is fixedly connected with the piston, the second end of the connecting rod is fixedly connected with the pressing part, the inner diameter of the piston is the same as that of the injection cylinder, and the arrangement ensures that the pushing pressing part can push out the medicine in the injection cylinder.
Further, the first end of the injection tube is matched with the injection port, and the second end of the injection tube is provided with a puncture needle.
Furthermore, the inside cavity that is of base of dosing, the base upper portion of dosing sets up soft material, soft material can select for use silica gel, and the pjncture needle can prick patient's skin and pass soft material, and the medicine can inject the base of dosing and flow through the semicircular canal through the pipe of dosing, reaches the effect of treatment.
Further, the length of the administration catheterization semicircular canal is 8-16mm; the drug delivery catheter can be ensured to be inserted deeper when being inserted into the semicircular canal, and is not easy to deviate from; optionally, the administration catheter insertion semicircular canal has a length of 10mm.
Furthermore, the diameter of the administration conduit is between 0.1 and 0.3mm, so that the diameter of the administration conduit is smaller than that of the semicircular canal, and the administration conduit can be normally inserted into the semicircular canal.
Furthermore, the administration catheter is made of soft materials, and the front end of the administration catheter is smooth, so that the semicircular canal is prevented from being pierced again by the front end of the administration catheter inserted into the semicircular canal, and the medicine is driven into perilymph fluid, so that the treatment effect is not achieved.
Further, before the administration catheter is placed, a window is formed in any one of the three semicircular canals, the window is arranged at a position close to the ampulla of the semicircular canals, and when the administration catheter is inserted into the semicircular canals, the direction of the insertion of the catheter is away from the ampulla of the semicircular canals.
Further, an expanding part is arranged at the position, which is 10mm away from the front end, of the administration catheter, and the diameter of the expanding part is larger than that of a window of the semicircular canal; the arrangement ensures that the expansion part of the administration tube can be clamped at the window of the semicircular tube after the administration tube is placed in the semicircular tube, so that the endolymph is prevented from leaking outwards, the administration tube can be prevented from slipping in the semicircular tube, and the disturbance to the receptor in the ampulla is minimal.
Further, when in implantation, a power drill is used for grinding part of mastoid bone, any one of the outer semicircular canal, the front semicircular canal and the rear semicircular canal is exposed, the part of bone of the semicircular canal is ground for windowing, the membrane semicircular canal is exposed, and a microtip needle is used for picking up the membrane semicircular canal and placing a medicine conduit at the window of the three semicircular canals, so that the stimulation to an inner ear receptor is avoided, and the microtip needle is inserted in a direction away from the ampulla; the total length of the administration catheter is set to be 150mm, and the infusion tube can be coiled in the mastoid cavity.
The invention has the beneficial effects that: the invention can repeatedly and accurately administer trace amount of medicine to the inner ear of a patient by arranging the medicine administration device, and provides a reliable administration way for the medicine treatment of inner ear diseases.
Drawings
FIG. 1 is a schematic view of the overall structure of the present invention;
FIG. 2 is a schematic view of the combination of the administration device and microdose of the present invention;
FIG. 3 is a schematic view of the structure of the drug delivery device of the present invention;
FIG. 4 is a schematic cross-sectional view of the micro-dispenser of the present invention mounted on a dispensing device;
FIG. 5 is a schematic cross-sectional view of a drug delivery device of the present invention;
FIG. 6 is a schematic diagram of a moving block according to the present invention;
FIG. 7 is a schematic view of the structure of the micro-dispenser of the present invention;
FIG. 8 is a schematic view of the structure of the drug delivery device of the present invention;
FIG. 9 is a schematic cross-sectional view of a drug delivery device of the present invention;
FIG. 10 is a schematic view of the structure of the drug delivery device of the present invention after being subcutaneously placed;
in the figure, 1, a drug delivery device housing; 2. a microdose feeder; 3. a drug administration base; 4. an administration catheter; 5. a driving motor; 6. a screw rod; 7. a fixing plate; 8. a moving block; 9. a polish rod; 10. a threaded hole; 11. a connecting rod; 12. making medicine blocks; 13. a slot-shaped through hole; 14. an arc-shaped groove; 15. a circular groove; 16. a cylindrical rod; 17. a blocking block; 18. a display screen; 19. a switch; 20. an adjustment button; 21. a power line; 22. a syringe; 23. an injection section; 24. a T-shaped groove; 25. a syringe; 26. a hand-held part; 27. a piston; 28. a connecting rod; 29. a pressing part; 30. a puncture needle; 31. a ampulla; 32. semicircular canal.
Detailed Description
The following detailed description of the embodiments of the present invention will be made more apparent to those skilled in the art from the following detailed description, in which the invention is embodied in several, but not all, embodiments of the invention. The invention may be embodied or applied in other specific forms and features of the following examples and examples may be combined with each other without conflict, all other examples being contemplated by those of ordinary skill in the art without undue burden from the present disclosure, based on the examples of the invention.
Example 1
Referring to fig. 1-10, a subcutaneous implantable device for re-administration of an inner ear of a semicircular canal 32 according to this embodiment comprises:
a medicine feeding device for precisely pushing the micro-medicine feeder 2 to precisely feed medicine; it comprises a drug delivery device housing 1 and a transmission structure, wherein the transmission structure is arranged inside the drug delivery device housing 1.
A micro-drug delivery device 2 for sucking therapeutic drug and delivering the drug out, and delivering the drug into a subcutaneous drug delivery device of a patient.
A drug delivery device; the ear-implanted dosing device comprises a dosing base 3 and a dosing guide tube 4, wherein after the dosing base 3 is implanted into the ear of a patient, the dosing guide tube 4 is arranged inside the ear of the patient, the tail end of the dosing guide tube 4 is inserted into a semicircular canal 32, the dosing guide tube 4 is fixedly connected with the dosing base 3, and the dosing guide tube 4 is communicated with the inside of the dosing base 3.
The micro-drug delivery device 2 is detachably connected with the drug delivery device, and the micro-drug delivery device 2 can be connected with a catheter to be pricked into the drug delivery base 3 to deliver drugs to the inside of the drug delivery base, so that the inner ear diseases can be treated.
Example 2
Referring to fig. 1-6, on the basis of embodiment 1, the following technical features are added in this embodiment: (the following specific settings are made for the structure of the drug delivery device): the transmission structure comprises a driving motor 5, a screw rod 6, a fixed plate 7 and a moving block 8; the fixed block comprises a first fixed block and a second fixed block; the driving motor 5 is fixedly connected with the screw rod 6, the fixed plates 7 are arranged on two sides of the screw rod 6, the screw rod 6 is rotationally connected with the fixed plates 7, the moving block 8 is arranged between the first fixed plate 7 and the second fixed plate 7, and the moving block 8 is movably connected with the screw rod 6.
The bottom of the driving motor 5 is provided with a mounting plate, at least two fixing holes are formed in the mounting plate, the driving motor 5 is fixed on the inner side of the bottom of the drug delivery device shell 1, and the inner side of the bottom of the drug delivery device shell 1 is provided with a hole matched with the fixing hole.
The length of the screw 6 is greater than the distance between the first and second fixed blocks.
The through holes are formed in the centers of the first fixing block and the second fixing block, the diameter of each through hole is larger than that of the screw rod 6, bearings are arranged in the through holes, the screw rod 6 is mounted on the bearings, and the second end of the screw rod 6 extends out of the through hole of the second fixing block to be fixedly connected with the driving motor 5.
At least one polish rod 9 is arranged between the first fixed block and the second fixed block; optionally, two polish rods 9 are provided between the first and second fixed blocks.
A threaded hole 10 is formed in the center of the moving block 8, the threaded hole 10 is matched with threads on the screw rod 6, and a through hole matched with the polished rod 9 is formed in the moving block 8; the moving block 8 is arranged between the first fixed block and the second fixed block, the screw rod 6 passes through the threaded hole 10, and the polished rod 9 passes through the through hole; the above arrangement ensures that the screw 6 rotates and the moving block 8 is movable between the first and second fixed blocks.
A connecting rod 11 is arranged on one side of the moving block 8, which is close to the front side surface of the drug delivery device shell 1, a drug spraying block 12 is arranged at the rear end of the connecting rod 11, a T-shaped groove 24 is arranged on the side surface of the drug spraying block 12, and the T-shaped groove 24 penetrates through the drug spraying block 12.
The front side of the drug delivery device shell 1 is provided with a groove-shaped through hole 13, and the length of the groove-shaped through hole 13 is set as the movement range of the moving block 8.
The side of the groove-shaped through hole 13 on the front side of the drug delivery device shell 1 is provided with an arc-shaped groove 14, the radian of the arc-shaped groove 14 is 120-180 degrees, the joint of the arc-shaped groove 14 and the groove-shaped through hole 13 is provided with a circular groove 15, and the circular groove 15 is perpendicular to the front side of the drug delivery device shell 1; alternatively, the arc of the arcuate recess 14 is set at 180 degrees.
The lower side of the arc-shaped groove 14 of the drug delivery device shell 1 is provided with a locking structure which comprises a cylindrical rod 16 and a locking block 17; the clamping block 17 is in a long strip shape, a round hole is formed in any side of the clamping block 17, the clamping block 17 is arranged on the cylindrical rod 16, and the clamping block 17 can rotate along the cylindrical rod 16; friction is generated between the locking block 17 and the cylindrical rod 16, and relative rotation can not occur when the locking block is not operated manually.
The upper part of the front side of the drug delivery device shell 1 is provided with a display screen 18, any side of the display screen 18 is provided with a switch 19 and at least two adjusting buttons 20, and the adjusting buttons 20 can adjust the drug delivery quantity and the drug delivery speed of the micro-drug delivery device 2.
The medicine feeding device shell 1 is internally provided with a control system which can control the rotating speed and the rotating time of the driving motor 5 and can be selected from the prior art.
The rear end of the drug delivery device housing 1 is provided with a power cord 21 for powering the various components.
Example 3
Referring to fig. 1-2,4, and 7, on the basis of embodiments 1-2, the following technical features (the following specific arrangements are provided for the structure of the micro-drug delivery device 2) are added: the micro-dispenser 2 includes a syringe 22, an injection portion 23, and a syringe 25; the syringe 22 is hollow, the injection part 23 is arranged in the syringe 22, the injection part 23 is movably connected with the syringe 22, the syringe 25 is arranged at the front end of the syringe 22, and the syringe 25 is detachably connected with the syringe 22. The syringe 22 has an internal volume of 30-50 microliters and the inner ear receptors are immersed in the endolymph fluid, which is approximately 34 microliters in total.
The injection port is arranged at the front end of the injection tube 22, the hand-held part 26 is arranged at the rear end of the injection tube 22, the hand-held part 26 can be placed in the circular groove 15, the middle part of the injection tube 22 can be placed in the arc groove 14, and the clamping structure can fix the injection tube 22 so as to prevent the injection tube 22 from falling out of the arc groove 14 when injecting medicines.
The injection part 23 comprises a piston 27, a connecting rod 28 and a pressing part 29, wherein a first end of the connecting rod 28 is fixedly connected with the piston 27, a second end of the connecting rod 28 is fixedly connected with the pressing part 29, the inner diameter of the piston 27 is the same as that of the injection cylinder 22, and the arrangement ensures that the medicine in the injection cylinder 22 can be pressed out by pushing the pressing part 29.
The first end of the syringe 25 is adapted to the injection port and the second end of the syringe 25 is provided with a needle 30.
Example 4
Referring to fig. 1,8 and 10, on the basis of embodiments 1 to 3, the following technical features (the following specific arrangement is made for the structure of the drug administration device) are added: the inside of the administration base 3 is hollow, a soft material is arranged on the upper part of the administration base 3, silica gel can be selected as the soft material, the puncture needle 30 can be inserted into the skin of a patient to penetrate through the soft material, and medicines can be injected into the administration base 3 to flow through the semicircular canal 32 through the administration catheter 4, so that the treatment effect is achieved.
The length of the administration catheter 4 inserted into the semicircular canal 32 is 8-16mm; the medicine feeding catheter 4 can be ensured to be inserted deeper when the medicine feeding catheter 4 is inserted into the semicircular canal 32, and the medicine feeding catheter 4 is not easy to be separated; alternatively, the length of the administration tube 4 inserted into the semicircular canal 32 is 10mm.
The diameter of the administration tube 4 is between 0.1 and 0.3mm, so that the diameter of the administration tube 4 is smaller than that of the semicircular canal 32, and the administration tube 4 can be normally inserted into the semicircular canal 32.
The administration tube 4 is made of soft material, and the front end of the administration tube 4 is smooth, so that the administration tube 4 is prevented from being inserted into the semicircular canal 32 and then the semicircular canal 32 is punctured again, and the medicine is driven into perilymph fluid, so that the treatment effect is not achieved.
Before the administration tube 4 is placed, a window is formed in any one of the three semicircular canals 32, the window is arranged at a position close to the ampulla 31 of the semicircular canals 32, and when the administration tube 4 is inserted into the semicircular canals 32, the direction of the insertion of the tube is away from the ampulla 31 of the semicircular canals 32; preferably, the outer semicircular canal 32 is selected so that the other two semicircular canals 32 are relatively difficult to expose during surgery.
An expanding part is arranged at the position 10mm away from the front end of the administration catheter 4, and the diameter of the expanding part is larger than that of the window of the semicircular canal 32; the above arrangement ensures that the enlarged portion of the administration line 4 will be captured within the window of the semicircular canal 32 after insertion, preventing the administration line 4 from slipping within the semicircular canal 32, and thus minimizing disturbance to the receptors within the ampulla 31.
Before implantation, the administration tube 4 uses a power drill to grind off part of mastoid bone, any one of the three semicircular canals 32 of the outer semicircular canal 32, the front semicircular canal 32 and the rear semicircular canal 32 is exposed, and a part of bone of the semicircular canal 32 is ground off to open a window, so that the membrane semicircular canal 32 is exposed, and a microtip is used for picking up the membrane semicircular canal 32 and placing the administration tube, so that the stimulation to an inner ear receptor is avoided, and the administration tube 4 is inserted in a direction away from the ampulla 31 of the semicircular canal 32; the total length of the administration tube 4 is set to be 150mm, and the infusion tube can be coiled in the mastoid cavity.
The drug delivery device is firstly installed and fixed under the skin, the drug delivery catheter 4 is implanted into the semicircular canal 32, the micro drug delivery device 2 is connected to the subcutaneous drug delivery device after the micro drug delivery device 2 pumps the drug, the drug delivery device can adjust the drug delivery amount, and the puncture needle 30 at the rear end of the micro needle drug delivery device is punctured into the skin behind the ear of a patient after the drug delivery amount is adjusted.
The above description of embodiments is only for the understanding of the present invention. It should be noted that it will be apparent to those skilled in the art that modifications can be made to the present invention without departing from the principles of the invention, and such modifications will fall within the scope of the claims.
Claims (7)
1. A subcutaneously implantable semi-structured inner ear repeat administration device comprising:
the drug delivery device is used for accurately pushing the micro drug delivery device to accurately deliver drugs; the drug delivery device comprises a drug delivery device shell and a transmission structure, wherein the transmission structure is arranged inside the drug delivery device shell;
a micro-drug delivery device for sucking therapeutic drugs and delivering the drugs out, and injecting the drugs into the skin of a patient; the medicine is used for gene therapy, stem cell therapy or biological targeting therapy;
a drug delivery device; the medical ear patch comprises a drug delivery base and a drug delivery catheter, wherein the drug delivery catheter is arranged in bone beside the ear of a patient after the drug delivery base is embedded in the ear of the patient, the tail end of the drug delivery catheter is inserted into a semicircular canal, the drug delivery catheter is fixedly connected with the drug delivery base, and the drug delivery catheter is communicated with the interior of the drug delivery base;
the micro-drug delivery device is detachably connected with the drug delivery device, and can be connected with a catheter to be pricked into the drug delivery base to deliver drugs to the drug delivery base so as to treat inner ear diseases;
before implantation, using a power drill to grind off part of mastoid bone, exposing any one of the outer semicircular canal, the front semicircular canal and the rear semicircular canal, and grinding off part of the bone of the semicircular canal to form a window, wherein the window is arranged at a position close to the ampulla of the semicircular canal; at the window, a microtip opens the membrane semicircular canal to place a drug catheter; when the medicine is inserted, the medicine guide pipe is inserted in the direction away from the ampulla of the semicircular canal, so as to avoid the stimulation to the inner ear receptor; the length of the administration catheter insertion semicircular canal is 8-16mm; the diameter of the administration conduit is between 0.1 and 0.3 mm; the administration catheter is made of soft materials, and the front end of the administration catheter is smooth; an expanding part is arranged at the position 10mm away from the front end of the administration catheter and is used for being clamped at a window of the semicircular canal; the diameter of the expansion part is larger than that of the semicircular tube window;
the total length of the administration catheter is set to be 150mm, and the infusion tube is coiled in the mastoid cavity; the inside of the administration base is hollow, a soft material is arranged at the upper part of the administration base, the puncture needle can be inserted into the skin of a patient to pass through the soft material, and the medicine can be injected into the administration base to flow through the semicircular canal through the administration catheter, so that the treatment effect is achieved;
the micro-drug feeder comprises a syringe, an injection part and a syringe; the injection part is arranged in the injection cylinder, the injection part is movably connected with the injection cylinder, the injection pipe is arranged at the front end of the injection cylinder, and the injection pipe is detachably connected with the injection cylinder; the syringe has an internal volume of 30-50 microliters.
2. The subcutaneously implantable semi-regulated in-canal re-administration device according to claim 1, wherein the transmission structure comprises a driving motor, a screw, a fixed plate and a moving block; the fixing plate comprises a first fixing plate and a second fixing plate; the driving motor is fixedly connected with the screw rod, the fixed plates are arranged on two sides of the screw rod, the screw rod is rotationally connected with the fixed plates, the moving block is arranged between the first fixed plate and the second fixed plate, and the moving block is movably connected with the screw rod; the bottom of the driving motor is provided with a mounting plate, the mounting plate is provided with at least two fixing holes, the driving motor is fixed on the inner side of the bottom of the shell of the drug delivery device, and the inner side of the bottom of the shell of the drug delivery device is provided with a hole matched with the fixing hole; the length of the screw rod is longer than the distance between the first fixing plate and the second fixing plate.
3. The subcutaneous implantable through-semicircular canal inner ear repeated administration device according to claim 2, wherein the centers of the first fixing plate and the second fixing plate are provided with through holes, the diameter of each through hole is larger than that of a lead screw, bearings are arranged in the through holes, the lead screws are arranged on the bearings, and the through holes, extending out of the second fixing plate, of the second ends of the lead screws are fixedly connected with a driving motor; at least one polish rod is arranged between the first fixing plate and the second fixing plate; two polish rods are arranged between the first fixing plate and the second fixing plate; the center of the moving block is provided with a threaded hole which is matched with the threads on the screw rod, and the moving block is provided with a through hole which is matched with the polish rod; the movable block is arranged between the first fixed plate and the second fixed plate, the screw rod penetrates through the threaded hole, and the polish rod penetrates through the through hole.
4. The subcutaneous implantable semi-structured inner ear repeated administration device according to claim 2, wherein a connecting rod is arranged on one side of the movable block, which is close to the front side surface of the administration device shell, a medicine beating block is arranged at the rear end of the connecting rod, a T-shaped groove is arranged on the side surface of the medicine beating block, and the T-shaped groove penetrates through the medicine beating block; the front side surface of the shell of the drug delivery device is provided with a groove-shaped through hole, and the length of the groove-shaped through hole is equal to the length of the movement range of the moving block; the side of the groove-type through hole on the front side of the shell of the drug delivery device is provided with an arc-shaped groove, the radian of the arc-shaped groove is 120-180 degrees, the joint of the arc-shaped groove and the groove-type through hole is provided with a circular groove, and the circular groove is perpendicular to the front side of the shell of the drug delivery device.
5. The subcutaneous implantable semi-structured inner ear repeat drug delivery device according to claim 1, wherein a locking structure is arranged at the lower side of the arc-shaped groove of the drug delivery device shell, and the locking structure comprises a cylindrical rod and a locking block; the clamping block is in a strip shape, a round hole is formed in any side of the clamping block, the clamping block is arranged on the cylindrical rod, and the clamping block can rotate along the cylindrical rod; friction is arranged between the clamping block and the cylindrical rod.
6. The subcutaneous implantable semi-structured inner ear repeated administration device according to claim 1, wherein a display screen is provided at the upper part of the front side of the administration device housing, a switch and at least two adjusting buttons are provided at either side of the display screen, and the adjusting buttons can adjust the administration amount and the administration speed of the microdose; the medicine feeding device is characterized in that a control system is arranged in the casing of the medicine feeding device, and the rotating speed and the rotating time of the driving motor can be controlled.
7. The subcutaneous implantable device for repeated administration via an inner ear of a semicircular canal according to claim 5, wherein the front end of the injection tube is provided with an injection port, the rear end of the injection tube is provided with a hand-held part, the hand-held part can be placed in the circular groove, the middle part of the injection tube can be placed in the arc groove, and the locking structure can fix the injection tube; the injection part comprises a piston, a connecting rod and a pressing part, wherein the first end of the connecting rod is fixedly connected with the piston, the second end of the connecting rod is fixedly connected with the pressing part, and the inner diameter of the piston is the same as that of the injection cylinder; the first end of the injection tube is matched with the injection port, and the second end of the injection tube is provided with a puncture needle.
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| CN202310342881.4A CN116035800B (en) | 2023-04-03 | 2023-04-03 | Subcutaneous implantation type repeated administration device through semicircular canal inner ear |
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| CN202310342881.4A CN116035800B (en) | 2023-04-03 | 2023-04-03 | Subcutaneous implantation type repeated administration device through semicircular canal inner ear |
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