CN103341228B - A kind of prefilled syringe - Google Patents
A kind of prefilled syringe Download PDFInfo
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- CN103341228B CN103341228B CN201310306383.0A CN201310306383A CN103341228B CN 103341228 B CN103341228 B CN 103341228B CN 201310306383 A CN201310306383 A CN 201310306383A CN 103341228 B CN103341228 B CN 103341228B
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- needle
- injection
- needle tubing
- top cover
- described needle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
- A61M5/3295—Multiple needle devices, e.g. a plurality of needles arranged coaxially or in parallel
- A61M5/3298—Needles arranged in parallel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
- A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened
- A61M5/288—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened by piercing without internal pressure increase
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- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
The present invention relates to technical field of medical instruments, particularly relate to a kind of disposable spininess pipe injection needle and comprise the prefilled syringe of this injection needle.This disposable spininess pipe injection needle comprises needle stand, needle tubing fixture, location structure and at least two needle tubings, needle tubing passes the through hole on described needle stand top cover and is fixedly installed on the top cover of described needle stand dispersedly by described needle tubing fixture, described needle tubing fixture is fixed in described location structure, the two ends of described needle tubing have needle point, vertically being thrust by this injection needle just can be subcutaneous by inject dispersedly the while of insulin, inject time is short, be conducive to the absorption of insulin, single needle tubing can be avoided to inject and to cause the local subcutaneous adipose hyperplasia and scleroma that cause because insulin gathers for a long time, be convenient to rotation injection, structure and manufacturing process simple, with low cost, and reduce syringe needle because of single get liquid needle tubing piercing process blocking and non-serviceable risk, improve the reliability of injection.
Description
Technical field
The present invention relates to technical field of medical instruments, particularly relate to a kind of prefilled syringe.
Background technology
Injection technique, injection device play key player in treating diabetes, even with selection insulin preparation no less important, concern the success or failure of glycemic control.A lot of medical personnel usually ignore the impact of injection technique on glycemic control itself with the diabetics accepting injection of insulin.Clinician often can angularly consider from insulin preparation, Blood glucose self-monitoring the reason not reaching expection glycemic target; but have ignored injection technique and injection device to the impact of glycemic control, and insulin enters by injection device the process played a role in human body is a very important link.Because partes corporis humani position is to the absorption property of there are differences of insulin, in injection of insulin to subcutaneous or Musclar layer, there is very big-difference in its absorption rate, and the muscle of resting state and kinestate also has very Big mutation rate to absorption of insulin situation.Improve insulin injection device and optimize injection of insulin technology, comprising the needle tubing selecting suitable number and length, note correct injection maneuver, rotation injection site, specification ground, avoids intramuscular injection etc., and these are significant to obtaining good glycemic control.
Injection needle in existing ordinary syringe all only has a needle tubing, because syringe size is comparatively large, (length is greater than 15 millimeters usually, external diameter is greater than 0.35 millimeter usually), be very suitable for the intramuscular injection of heavy dose of medicinal liquid, be not suitable for the subcutaneous injection of per injection amount seldom but to medicinal liquids such as the very high insulins of accuracy of dose requirement.In injection of insulin field, because of insulin injection pen have simple and convenient and easy to study, dosage accurately, facilitate durable, injection time pain obviously reduce, imitate the advantages such as good, now adopted by diabetics widely.One end of present various commercially available insulin injection pen is all provided with injection memorizer, need by the column jacket casing of disposable pen injection needle on the interface of injection memorizer during use, the needle tubing meanwhile in column cylinder can pierce through the elastic layer of injection top of memory to extract medicinal liquid.Current insulin injection pen injection needle all only has a needle tubing, compared with normal injection syringe needle, is only needle tubing thinner (external diameter is 0.23-0.33mm), needle tubing length shorter (5-12.8mm) for thrusting skin.
As can be seen here, in existing injection of insulin technology, each syringe needle only has a needle tubing, when injecting with dose, medicament is all concentrated and is injected at same position, can cause obviously increase inject time by epidermis to the restriction of medicinal liquid absorption rate, because insulin itself is kind of a somatomedin, insulin will inevitably cause this position subcutaneous fat hypertrophy in gathering for a long time of injection site and produce scleroma.Here inject from now on, the absorbance of insulin will obviously decline again, and the performance that must affect drug effect causes the instability of glycemic control.In practical operation, fail to spread completely and absorption because inject in the subcutaneous medicinal liquid short time, often have medicinal liquid and ooze from pinprick, cause leakage, so just cannot guarantee the accuracy of therapeutic dose.
China's injection of insulin state of the art survey result display, about has the patient injection site of 31.1% to occur lump, wherein ninety percent occurs in abdominal part, but still have patient to select at adipose hyperplasia injection location.In fact, the position that human body is applicable to insulin injection not only abdominal part, outside large leg outer side, arm, the position such as 1/4 place and buttocks can.The treatment phase due to diabetics is very long and all inject 3 to 4 times every day, requirement must between abdominal part, arm, thigh, buttocks rotation insulin injection to ensure that injection site has higher subcutaneous absorption rate and concordance thereof as far as possible, so just can ensure curative effect, avoid the probability developed complications.But, because the needle tubing on existing injection needle is all longer, must adopt for avoiding intramuscular injection and pinch the injection such as skin, inclination needle tubing skill, and when arm, buttock injections, sufferers themselves just inconvenience adopts above-mentioned injecting method, this namely many patients only select the basic reason at abdomen injection.
Pain during injection obviously can increase with the degree of depth of thrusting, still can allow many patients especially infant inspire awe even from distance.Owing to each syringe needle only having a needle tubing, when injecting with dose, the needle tubing length degree of depth that is shorter, that thrust is more shallow, although pain can be reduced, but can cause obviously increase inject time to the restriction of medicinal liquid absorption rate by epidermis, and insulin will inevitably cause this position subcutaneous fat hypertrophy and produce scleroma gathering for a long time of injection site.
Above-mentioned factor can bring much inconvenience to patient undoubtedly, and To know is easy, but to do is difficult, reduces patient and adopts correct method to carry out the compliance of injection for curing, and affect the treatment.
In addition, the injection needles head on existing insulin injection pen must support the use by bound insulin injection pen, separately deposits at ordinary times, fits together during use temporarily again, and whole injection device volume and weight are comparatively large, and are only applicable to insulin injection.
At present, " disposable array miniature injection needle head " that Chinese invention patent number is ZL201110317397.3 adopts one to get, and structure that liquid pin converts many micropins to through micro-cavities can solve more above-mentioned problems, and the method be installed on insulin injection pen is identical with existing commercially available novopen syringe needle, but its structure and manufacturing process are comparatively complicated, cause cost also higher.
Therefore, for above deficiency, the invention provides a kind of disposable spininess pipe injection needle and comprise the prefilled syringe of this injection needle.
Summary of the invention
(1) technical problem that will solve
The object of this invention is to provide a kind of disposable spininess pipe injection needle, solve on the one hand the injection that exists when existing novopen injection needles head uses subcutaneous too concentrate to cause absorbing slowly, easily make subcutaneous the generations scleroma in injection site, easy-to-leak liquid, inject time long and awkward problem, another aspect solves the higher problem of the structure of existing array injection needle existence and complex manufacturing technology and cost simultaneously.
Another object of the present invention is to provide a kind of prefilled syringe comprising this disposable spininess pipe injection needle and injects application portability to improve.
(2) technical scheme
In order to solve the problems of the technologies described above, the invention provides a kind of disposable spininess pipe injection needle, it comprises needle stand, needle tubing fixture, location structure and at least two needle tubings, described needle stand is one end open, the other end has the column cylinder of top cover, the top cover of described needle stand offers through hole, described needle tubing passes the through hole on the top cover of described needle stand and is fixedly installed on the top cover of described needle stand dispersedly by described needle tubing fixture, or/and under top cover on the top cover that described location structure is arranged on described needle stand, described needle tubing fixture is fixed in described location structure, the two ends of described needle tubing have needle point.
Wherein, described needle tubing fixture comprises substrate portion, and described substrate portion is fixed in described location structure.
Wherein, described needle tubing fixture also comprises the filling part be connected with described substrate portion, and described filling part stretches into or passes the through hole of described top cover.
Wherein, described location structure is location double wall, and the inner surface of described location double wall has groove for clamping the substrate portion of described needle tubing fixture.
Wherein, described needle tubing is consistent with the number of described through hole, and each described needle tubing to be positioned among each through hole and the distribution in array.
Wherein, the normal direction of the liquid outlet of at least two described needle points is different.
Wherein, to stretch out the partial-length of described location structure different at least two needle tubings.
Wherein, the described substrate portion of needle tubing fixture is polymer with the material of filling part or is the position contacted with needle tubing in the substrate portion of sqtructural adhesive or described needle tubing fixture and is filled with structural adhesive, the material at other position of substrate portion is polymer, and the material of the filling part of described needle tubing fixture is structural adhesive.
Wherein, the length that described needle tubing stretches out the part that described location structure is also injected for skin puncture is 0.2mm ~ 4mm, it is 0.5mm ~ 15mm that described needle tubing is positioned at described column cylinder for extracting the length of the part of injection, the external diameter of described needle tubing is 60um ~ 450um, and internal diameter is 30um ~ 250um.
Wherein, be arranged with needle tube protecting sleeve outside the location structure on the top cover of described needle stand, be arranged with needle stand protective sleeve outside described needle stand and needle tube protecting sleeve, the opening part of described needle stand protective sleeve bottom is provided with sealing material layer.
Present invention also offers a kind of prefilled syringe comprising above-mentioned disposable spininess pipe injection needle, it also comprises the injection memorizer matched with the inwall of described column cylinder, described injection memorizer comprises cylindrical shell, elastomer layer and piston, the top of described cylindrical shell and bottom are equipped with opening and cylindrical shell are provided with containing mark, described elastomer layer is positioned at the opening of top for sealed cylinder top of cylindrical shell, described piston is arranged on the bottom of described cylindrical shell, the bottom of described cylindrical shell is also connected with bending segment, the free end of described bending segment is connected or clamping with the outer wall thread of described column cylinder.
(3) beneficial effect
Technique scheme tool of the present invention has the following advantages: disposable spininess pipe injection needle provided by the invention makes multiple needle tubing directly pass the through hole on described needle stand top cover and be fixedly installed on the top cover of described needle stand dispersedly by described needle tubing fixture, all there is needle point at the two ends of needle tubing, be respectively used to get liquid and injection, the insulin of doses can be injected simultaneously dispersedly subcutaneous like this, inject time is short, be conducive to the absorption of insulin, no leakage, effectively can avoid injection site subcutaneous fat hypertrophy and produce scleroma, simultaneously the structure of this disposable spininess pipe injection needle and manufacturing process simple, with low cost, and reduce syringe needle because of single get liquid needle tubing piercing process blocking and non-serviceable risk, improve the reliability of injection, the length of stretching out the part that described location structure is also injected for skin puncture due to needle tubing is shorter, can consider to pinch the regular injection skill such as skin, needle tubing inclination, can need not worry to cause intramuscular injection in multiple effective injection site injection such as arm, thigh, abdominal part very easily, disposable spininess pipe injection needle and injection bin are combined by the prefilled syringe that the embodiment of the present invention provides, use more convenient, device small volume and less weight, and be not limited to injection of insulin, also go for other drug injection, application prospect is more extensive.
Accompanying drawing explanation
Fig. 1 is the structure sectional view of disposable spininess pipe injection needle in the embodiment of the present invention 1;
Fig. 2 is the structure sectional view of locating the double wall disposable spininess pipe injection needle different from Fig. 1 in the embodiment of the present invention 1;
Fig. 3 is the structure sectional view of the disposable spininess pipe injection needle that in the embodiment of the present invention 1, a kind of needle tubing fixture is different from Fig. 1;
Fig. 4 is the structure sectional view of the disposable spininess pipe injection needle that in the embodiment of the present invention 1, another kind of needle tubing fixture is different from Fig. 1;
Fig. 5 is the structure sectional view of injection needles head in the embodiment of the present invention 2;
Fig. 6 is the structure sectional view of the disposable spininess pipe injection needle that in the embodiment of the present invention 2, needle tubing fixture is different from Fig. 3;
Fig. 7 is the structure sectional view of the disposable spininess pipe injection needle that in the embodiment of the present invention 2, needle tubing fixture is different from Fig. 4;
Fig. 8 is the perspective view of disposable spininess pipe injection needle in the embodiment of the present invention 1;
Fig. 9 is the perspective view of locating the double wall disposable spininess pipe injection needle different from Fig. 8 in the embodiment of the present invention 1;
Figure 10 is the structure sectional view of prefilled syringe in the embodiment of the present invention 3.
In figure, 1: needle stand; 2: needle tubing; 3: top cover; 4: through hole; 5: column cylinder; 6: location double wall; 7: substrate portion; 8: groove; 9: needle tubing fixture; 10: filling part; 11: needle tube protecting sleeve; 12: needle stand protective sleeve; 13: sealing material layer; 14: injection memorizer; 15: injection; 16: elastomer layer; 17: piston; 18: be threaded district.
Detailed description of the invention
Below in conjunction with drawings and Examples, the specific embodiment of the present invention is described in further detail.Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
As shown in Figure 1, the one that the embodiment of the present invention provides disposable spininess pipe injection needle, it comprises needle stand 1, three needle tubings 2, needle tubing fixture 9, location double wall 6, needle tube protecting sleeve 11, needle stand protective sleeve 12 and sealing material layer 13, this needle stand 1 is for one end open, the other end have the column cylinder 5 of top cover 3, the top cover 3 of needle stand 1 offers a through hole 4, described needle tubing 2 passes the through hole 4 of the top cover 3 of needle stand 1 and is fixedly installed on the top cover 3 of needle stand 1 by needle tubing fixture 9 array, the two ends of needle tubing 2 all have needle point, the needle point structure at two ends can be different, wherein being positioned at needle point above top cover 3 for thrusting skin and injection, being placed in needle point in column cylinder 5 for thrusting injection memorizer to extract medicinal liquid, needle tubing fixture 9 is a convex structure, comprise the substrate portion 7 and filling part 10 that are connected as a single entity, substrate portion 7 is positioned at above top cover 3, filling part 10 is through through hole 4, because needle tubing is usually very thin and to be positioned at the part of column cylinder longer, the contact length of needle tubing 2 and needle tubing fixture 9 can be increased by filling part 10, and effectively reduce the length of the needle tubing 2 exposed in column cylinder 5, thus make needle tubing 2 relatively firm and mechanical strength improves further and is beneficial to thrust injection memorizer and gets liquid, the length of this filling part 10 certain would not affect needle tubing 2 and get liquid, substrate portion 7 and filling part 10 adopt polymeric material or structure adhesive integrally manufactured, location double wall 6 is provided with for limiting the substrate portion 7 of needle tubing fixture 9 above top cover 3, prevent substrate portion 7 from moving radially at needle tubing 2, the inwall of location double wall 6 has groove 8, substrate portion 7 is stuck in groove 8, needle tubing fixture 9 can be made more firm, structural adhesive can certainly be used to be bonded on needle stand 1 top cover 3 by the substrate portion 7 of needle tubing fixture 9, location double wall 6 outer wall is arranged with needle tube protecting sleeve 11, needle stand protective sleeve 12 can be arranged with in the outside of needle tube protecting sleeve 11 and needle stand 1, the opening part of needle stand protective sleeve 12 bottom is provided with sealing material layer 13, and encapsulant can select the medical materials such as sealing dialyzing paper.Certainly, in the present embodiment, the number of needle tubing 2 is not limited to three, and can be two, four, five or more more number, the distribution of needle tubing 2 be not limited to the arrangement of array, as long as can be arranged on dispersedly on needle tubing fixture 9.
The present embodiment is by being arranged on needle tubing fixture 9 dispersedly by needle tubing 2, needle tubing fixture 9 is firmly arranged on the top cover 3 of needle stand 1 by location double wall 6 again, thus define array spininess pipe 2 injection needle, by this syringe needle, the insulin of doses can be injected dispersedly simultaneously subcutaneous, inject time is short, be conducive to the quick absorption of insulin and not easy-to-leak liquid, avoid single needle tubing insulin injection to accumulate in injection site overlong time and cause subcutaneous fat hypertrophy and the phenomenon producing scleroma, during injection, can vertical injection, easy to use; The present embodiment three needle tubings 2 are directly through the through hole 4 of needle stand 1, and be arranged on needle stand top cover 3 by the needle tubing fixture 9 that material is structural adhesive, structure and manufacturing process simple, with low cost, needle tubing reliability is high, and reduce syringe needle because of indivedual needle tubing 2 get liquid end piercing process blocking and non-serviceable risk, improve the reliability of injection; Needle tube protecting sleeve 11 and needle stand protective sleeve 12 can select multiple material as the preparation of the plastics such as polypropylene, polrvinyl chloride; can prevent syringe needle bending in moving process from damaging needle tubing 2 by needle tube protecting sleeve 11; by arranging needle stand protective sleeve 12 and sealing material layer 13, after the sterilizations such as oxirane, just can ensure that syringe needle and needle stand 1 are in clean aseptic environment in the period of use always at syringe needle.
Different from Fig. 1, because the several needle tubings in Fig. 2 form a line, needle tubing fixture 9 becomes inverted L-shaped, also needle tubing fixture 9 firmly can be fixed, structural adhesive can also be adopted in addition to increase constant intensity further even if do not arrange groove 8 in the double wall 6 of part location; Needle tubing fixture 9 in Fig. 3 is directly reduced to substrate portion 7, and this substrate portion 7 is surface plate, but also can be curved slab.
Further, as shown in Figure 4, needle tubing fixture 9 in the present embodiment also can have other to be out of shape, its substrate portion 7 can by polymer as plastic plate and structural adhesive be made, the position be connected with needle tubing 2 in plastic plate is filled with structural adhesive, and the material of the filling part 10 of needle tubing fixture 9 is structural adhesive.
Needle tubing 2 in the present invention can select the medical metal needle tubings such as rustless steel, structural adhesive can select the structural adhesive of epoxy resin or other materials type, and epoxy resin structural adhesive can be formed with the multiple material comprising metal needle tubing 2 and firmly bond.Needle stand 1 can select the plastics preparations such as polypropylene, polyethylene, polrvinyl chloride.Wherein, locate double wall 6 can with needle stand 1 integral production.Certainly, location double wall 6 also can with needle tubing fixture 9 integral production, now locating slot need be set on the top cover 3 of needle stand 1, then be fixed in this locating slot.
Embodiment 2
Present embodiments provide another disposable spininess pipe injection needle, the difference of itself and embodiment 1 is mainly the number of through hole 4 on needle stand top cover 3, needle tubing fixture 9 and locates the structure of double wall 6.
As shown in Figure 5, the top cover 3 of needle stand 1 arranges three through hole 4 arrays, adopt epoxy resin structural adhesive to stick rustless steel needle tubing 2 that three two ends all have a needle point by agent be directly fixed on respectively there is through hole 4 array needle stand top cover 3 on, the substrate portion 7 of needle tubing fixture 9 and filling part 10 are epoxy resin structural adhesive and stick agent, because needle tubing fixture 9 in the present embodiment is all by being filled in by structural adhesive in three through holes 4 and needle stand top cover 3 being formed, needle tubing fixture 9 and can be located double wall 6 and bonds well with through hole 4 inwall, so do not need to arrange groove 8 on the double wall 6 of location.
Further, as shown in Figure 6, in order to improve the steadiness of needle tubing 2 on needle tubing fixture 9, the substrate portion 7 of needle tubing fixture 9 also can be set below needle stand top cover 3, the substrate portion 7 of needle tubing fixture 9 on needle stand top cover 3 and under needle stand top cover 3 be arranged in through hole 4 filling part 10 and be connected as a single entity, correspondingly, the location double wall 6 limiting needle tubing fixture 9 is also set for 3 times at needle stand top cover.
Further, as shown in Figure 7, through hole 4 on needle stand top cover 3 can also can be bellmouth for straight hole, epoxy resin structural adhesive can be adopted to stick agent fixing needle tubing 2 above needle stand top cover 3, also epoxy resin structural adhesive can be adopted to stick agent fixing needle tubing 2 below needle tubing top cover 3, epoxy resin structural adhesive sticks after agent is solidified and namely forms needle tubing fixture 9, the plate face of the substrate portion 7 of needle tubing fixture 9 can be plane also can be curved surface, location double wall 6 can not be set in the below of needle stand 1 top cover 3, but bossing is set, this bossing is the downward extension of conical through-hole 4 array region on needle stand 1 top cover 3, through hole 4 on this bossing is the extension that on needle stand top cover 3, through hole 4 is downward, this bossing plays restriction effect to needle tubing fixture 9 equally.
As shown in Figure 6 and Figure 7, being beneficial to absorb and reduce the accumulation time of medicinal liquid in subcutaneous local to improve injection dispersibility in vivo, the normal direction that needle tubing 2 stretches out length and the needle point liquid outlet of top cover 3 being located double wall 6 can being set and being not quite similar.The needlepoint form at needle tubing 2 two ends also can be different from size, but must firm in structure, be convenient to puncture and not easily blocking pipe.
As shown in Figure 8 and Figure 9, the location double wall 6 on top cover 3 can adopt various shape, both can be square structure also can be circular configuration, both can be all round closure continuous print double wall, and also can adopt the double wall of other compartment.Column cylinder 5 can adopt the circle similar with existing commercially available injection pen syringe needle usually, but also can be other shapes such as polygon, as long as can firmly be enclosed within injection memorizer 14 interface.
In the embodiment of the present invention, needle tubing array can be the one-dimensional array be arranged in a row, and also can be flat two-dimensional arrays.For the ease of plug operation, anti-slip veins can be set at the outer surface of column cylinder 5, even also can anti-slip veins be set at the outer surface of needle tube protecting sleeve 11; The inwall of needle stand protective sleeve 12 can also arrange projection more easily to take out needle stand 1; According to the structure of injection memorizer 14 interface, can also its corresponding screw thread or fixing bayonet socket be set on the barrel of column cylinder 5, for removably connecting with injection bin.
Further, the external diameter of needle tubing 2 is 60um ~ 450um, internal diameter is 30um ~ 250um, and stretching out in location double wall 6 is 0.2mm ~ 4.0mm for needle tubing 2 length of puncture injection, and being arranged in column cylinder 5 for extracting the needle tubing length of injection from injection bin is 0.5mm ~ 15mm.Because very thin and for thrusting injection the needle tubing length of the needle tubing adopted is very short, need not consider that pinching the injection maneuvers such as skin just effectively can adopt vertical injection in injection site at arm, thigh, abdominal part etc., injection needle 2 all thrusts subcutaneous, very easy to use, be convenient to implement rotation injection location and do not have the risk of intramuscular injection, easily can realize hypodynia even without pain injection, and then significantly improve injection compliance and the therapeutic effect of patient.
Needle tubing 2 can adopt the multiple medical metal material manufactures such as rustless steel, and needle stand 1 can select the plastics such as polypropylene, polyethylene to prepare.
Above-mentioned injection needle is except can be used for combining with existing novopen and using, also can use with the syringe of existing or future other medicines or injection memory combination as selected suitable interface structure, and owing to there being multiple needle tubing to be used as liquid taking port in column cylinder of the present invention, the plurality of liquid taking port can use with the injection memory combination of different pharmaceutical respectively.
Embodiment 3
As shown in Figure 10, present embodiments provide a kind of prefilled syringe comprising disposable spininess pipe injection needle in above-described embodiment, it is made up of disposable spininess pipe injection needle and injection bin, injection bin matches with the inwall of column cylinder 5 and can relative movement, injection memorizer comprises cylindrical shell, elastomer layer 16 and piston 17, top and the bottom of cylindrical shell are equipped with opening, the opening at cylindrical shell top is corresponding with needle tubing 2, elastomer layer 16 is positioned at the opening of top for sealed cylinder top of cylindrical shell, simultaneously, elastomer layer 16 is easy to be pierced through by the needle point of column cylinder 5 inner needle tube 2, the material selection rubber of general elastomer layer 16, piston 17 is arranged on the bottom of cylindrical shell, space between piston 17 and elastomer layer 16 stores injection 15, the opening convenient pressing piston 17 of cylinder body bottom, injection memorizer 14 is connected with column cylinder 5, specifically, the bottom of cylindrical shell is also connected with bending segment, the free end of bending segment to the outer wall of column cylinder 5 all has the corresponding district 18 that is threaded, injection memorizer 14 is connected in this district 18 that is threaded with column cylinder 5.The free end of certain bending segment also can be provided with on the outer wall of column cylinder 5 bayonet arrangement matched, and both also can take bayonet socket clamping.The cylindrical shell of column cylinder and injection memorizer is made by the transparent material such as polypropylene of routine, the cylindrical shell of such injection memorizer can be arranged the containing mark being convenient to observe.
During use, first manual rotation injection bin can be produced be threaded district 18 or fixing bayonet socket, the column cylinder 5 of injection memorizer 14 and disposable spininess pipe injection needle can relative sliding afterwards, now press injection bin to move towards disposable spininess pipe injection needle, and by the elastomer on needle pierces top until contact injection 15, the piston 17 finally promoting bottom extrudes injection and implements injection by needle tubing.The present embodiment is by combining disposable spininess pipe injection needle and injection bin, convenient to use, device small volume and less weight, and is not limited to injection of insulin, also goes for other drug injection, applies more extensive.
Disposable spininess pipe injection needle and injection bin can be assembled into one by manufacturer; and be together sterilized and be enclosed in needle stand protective sleeve 12; also at ordinary times disposable spininess pipe injection needle and injection bin can be deposited respectively, during use, be assembled into one again.
The various products of above-described embodiment, all can adopt the processing technique of existing maturation and the routine of regulation or the manufacture of new medical material, and manufacturing process is simple, with low cost.
In sum, many needle tubings 2 are passed the through hole 4 of needle stand 1 top cover 3 and are fixedly installed on the top cover 3 of needle stand 1 by needle tubing fixture 9 array by the disposable spininess pipe injection needle that the embodiment of the present invention provides, needle tubing fastness is high, the insulin of doses can be injected simultaneously dispersedly subcutaneous, inject time is short, be conducive to the absorption of insulin, no leakage, avoid the injection of single needle tubing to cause insulin to accumulate in injection site overlong time to cause subcutaneous fat hypertrophy and the phenomenon that produces scleroma, structure and manufacturing process simple, with low cost, reduce syringe needle because of needle tubing 2 get liquid end piercing process blocking and non-serviceable risk, improve the reliability of injection, and owing to adopting very thin and for thrusting injection the needle tubing length of needle tubing very short, just can direct vertical inserting needle without the need to pinching skin, injection needle 2 all thrusts subcutaneous, be convenient to implement rotation injection location and do not have the risk of intramuscular injection, easily can realize hypodynia even without pain injection, and then significantly improve injection compliance and the therapeutic effect of patient, disposable spininess pipe injection needle and injection bin are combined by the prefilled syringe that the embodiment of the present invention provides, convenient to use, device small volume and less weight, and be not limited to injection of insulin, also go for other drug injection, apply more extensive.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the prerequisite not departing from the technology of the present invention principle; can also make some improvement and modification, these improve and modification also should be considered as protection scope of the present invention.
Claims (8)
1. a prefilled syringe, it is characterized in that: it comprises needle stand (1), needle tubing fixture (9), location structure and at least two needle tubings (2), described needle stand (1) is one end open, the other end has the column cylinder (5) of top cover (3), the top cover (3) of described needle stand (1) offers through hole (4), described needle tubing (2) is fixedly installed on the top cover (3) of described needle stand (1) through the through hole (4) on the top cover (3) of described needle stand (1) and by described needle tubing fixture (9) dispersedly, the top cover (3) that described location structure is arranged on described needle stand (1) is upper or/and under top cover (3), described needle tubing fixture (9) is fixed in described location structure, the two ends of described needle tubing (2) have needle point,
Described needle tubing fixture (9) comprises substrate portion (7), and described substrate portion (7) is fixed in described location structure;
Described needle tubing fixture (9) also comprises the filling part (10) be connected with described substrate portion (7), and described filling part (10) stretches into or passes the through hole (4) of described top cover (3);
Also comprise the injection memorizer (14) matched with the inwall of described column cylinder (5), described injection memorizer comprises cylindrical shell, elastomer layer (16) and piston (17), the top of described cylindrical shell and bottom are equipped with opening and cylindrical shell are provided with containing mark, described elastomer layer (16) is positioned at the opening of top for sealed cylinder top of cylindrical shell, described piston (17) is arranged on the bottom of described cylindrical shell, the bottom of described cylindrical shell is also connected with bending segment, the free end of described bending segment is connected or clamping with the outer wall thread of described column cylinder (5).
2. prefilled syringe according to claim 1, it is characterized in that: described location structure is location double wall (6), and the inner surface of described location double wall (6) has groove (8) for clamping the substrate portion (7) of described needle tubing fixture (9).
3. prefilled syringe according to claim 1, it is characterized in that: described needle tubing (2) is consistent with the number of described through hole (4), each described needle tubing (2) to be positioned among each through hole (4) and the distribution in array.
4. prefilled syringe according to claim 1, is characterized in that: the normal direction of the liquid outlet of at least two described needle points is different.
5. prefilled syringe according to claim 1, is characterized in that: at least two described needle tubings (2) stretch out the partial-length difference of described location structure.
6. prefilled syringe according to claim 3, it is characterized in that: the substrate portion (7) of described needle tubing fixture (9) is polymer with the material of filling part (10) or is the position contacted with needle tubing (2) in the substrate portion (7) of sqtructural adhesive or described needle tubing fixture (9) and is filled with structural adhesive, the material at other position of substrate portion (7) is polymer, and the material of the filling part (10) of described needle tubing fixture (9) is structural adhesive.
7. the prefilled syringe according to any one of claim 1-6, it is characterized in that: the length that described needle tubing (2) stretches out the part that described location structure is also injected for skin puncture is 0.2mm ~ 4mm, it is 0.5mm ~ 15mm that described needle tubing (2) is positioned at described column cylinder (5) for extracting the length of the part of injection, the external diameter of described needle tubing (2) is 60um ~ 450um, and internal diameter is 30um ~ 250um.
8. prefilled syringe according to claim 1; it is characterized in that: outside the location structure on the top cover (3) of described needle stand (1), be arranged with needle tube protecting sleeve (11); be arranged with needle stand protective sleeve (12) outside described needle stand (1) and needle tube protecting sleeve (11), the opening part of described needle stand protective sleeve (12) bottom is provided with sealing material layer (13).
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310306383.0A CN103341228B (en) | 2013-07-19 | 2013-07-19 | A kind of prefilled syringe |
| PCT/CN2014/082577 WO2015007243A1 (en) | 2013-07-19 | 2014-07-21 | Disposable multi-needle injection needle and pre-fillable syringe having same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310306383.0A CN103341228B (en) | 2013-07-19 | 2013-07-19 | A kind of prefilled syringe |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103341228A CN103341228A (en) | 2013-10-09 |
| CN103341228B true CN103341228B (en) | 2015-08-12 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310306383.0A Active CN103341228B (en) | 2013-07-19 | 2013-07-19 | A kind of prefilled syringe |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN103341228B (en) |
| WO (1) | WO2015007243A1 (en) |
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| HUE049678T2 (en) | 2008-12-02 | 2020-10-28 | Allergan Inc | Injection device |
| US20140350518A1 (en) | 2013-05-23 | 2014-11-27 | Allergan, Inc. | Syringe extrusion accessory |
| CN103341228B (en) * | 2013-07-19 | 2015-08-12 | 清华大学 | A kind of prefilled syringe |
| US10029048B2 (en) | 2014-05-13 | 2018-07-24 | Allergan, Inc. | High force injection devices |
| US10226585B2 (en) | 2014-10-01 | 2019-03-12 | Allergan, Inc. | Devices for injection and dosing |
| CA2976544A1 (en) | 2015-03-10 | 2016-09-15 | Allergan Pharmaceuticals Holdings (Ireland) Unlimited Company | Multiple needle injector |
| EP3202448A1 (en) * | 2016-02-08 | 2017-08-09 | F. Hoffmann-La Roche AG | Device and method for safe and easy removal of a needle shield element from a pharmaceutical syringe |
| MX2018009910A (en) * | 2016-02-17 | 2018-09-11 | Polymer Technology Systems Inc | Systems and methods for a blood collector with enhanced volume using capillary techniques. |
| CN109310827B (en) | 2016-04-08 | 2021-09-07 | 阿勒根公司 | Aspiration and injection device |
| CN106669025B (en) * | 2017-01-12 | 2023-11-28 | 清华大学 | Hollow metal microneedle array, injection needle, syringe and prefilled syringe |
| USD867582S1 (en) | 2017-03-24 | 2019-11-19 | Allergan, Inc. | Syringe device |
| CN107802493A (en) * | 2017-11-23 | 2018-03-16 | 中国人民解放军陆军军医大学第二附属医院 | A kind of syringe |
| EP3744367A1 (en) * | 2019-05-29 | 2020-12-02 | Sooil Development Co., Ltd. | Needle infusion set for insulin infusion |
| CN110897754A (en) * | 2019-12-13 | 2020-03-24 | 中国水产科学研究院黑龙江水产研究所 | Rainbow trout attacks poisonous syringe for experiment |
| CN113577461B (en) * | 2021-08-10 | 2022-03-29 | 温州康洲医疗器材有限公司 | Self-aligning needle seat |
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| CN102327656A (en) * | 2011-10-18 | 2012-01-25 | 清华大学 | Disposable array miniature injection needle head |
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Also Published As
| Publication number | Publication date |
|---|---|
| WO2015007243A1 (en) | 2015-01-22 |
| CN103341228A (en) | 2013-10-09 |
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