CN210697699U - Experimental animal microdialysis probe - Google Patents
Experimental animal microdialysis probe Download PDFInfo
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- CN210697699U CN210697699U CN201921110064.1U CN201921110064U CN210697699U CN 210697699 U CN210697699 U CN 210697699U CN 201921110064 U CN201921110064 U CN 201921110064U CN 210697699 U CN210697699 U CN 210697699U
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Abstract
The utility model relates to an experimental animal microdialysis probe, which comprises a first melting capillary silicon tube, a second melting capillary silicon tube, a hollow cellulose dialysis membrane, a microdialysis main body part, a middle connecting part, a sample output unit and a sample introduction unit; the hollow cellulose dialysis membrane is connected with one end of the microdialysis main body part, the other end of the microdialysis main body part is connected with one end of the middle connecting part, and the other end of the middle connecting part is respectively connected with the sample output unit and the sample introduction unit; the first fused capillary silicon tube passes through the hollow cellulose dialysis membrane, the microdialysis main body part, the middle connecting part and the sample output unit, and the second fused capillary silicon tube passes through the hollow cellulose dialysis membrane, the microdialysis main body part, the middle connecting part and the sample introduction unit. The utility model discloses a: the probe dialysis membrane area is replaced for repeated use; changing dialysis membranes with different properties to expand the range of compounds that can be collected; the length of the dialysis membrane can be adjusted to compensate for the sensitivity limitation of the detector.
Description
Technical Field
The utility model belongs to the technical field of medical science biological assay apparatus, specifically relate to an experimental animals microdialysis probe.
Background
Microdialysis is a practical technique in animal research, which can continuously collect samples under the waking state of a living body so as to detect free small molecule active substances. The basic principle is as follows: implanting an effective membrane region of a dialysis probe into a target tissue region, filling equal-osmosis perfusion fluid into a microdialysis probe by a microdialysis constant-flow filling pump, diffusing small-molecular active substances in tissues into the membrane from the outside along a concentration gradient based on a passive diffusion principle when the perfusion fluid flows through a probe dialysis membrane, sending the small-molecular active substances out of the body along with the perfusion fluid, and selecting a proper detector according to different detection samples to detect the level of the bioactive substances to be detected in the small-molecular active substances.
In the microdialysis technology, the core element is a microdialysis probe which consists of a dialysis membrane, a fused capillary silicon tube, an outer sleeve rubber tube, a stainless steel metal sleeve, a liquid inlet tube and a liquid outlet tube. The micro-dialysis experimental result is directly influenced by factors such as the recovery rate, the adjustability of the type and the length of the dialysis membrane, the tissue damage of a dialysis target area and the like. Probes are manufactured by selecting corresponding probe types and sizes according to the types of experimental animals and the sizes of target tissues and organs and the principle of ensuring the completeness of the functions of the tissues and organs. Currently, the microdialysis probes used are commercial microdialysis probes directly purchased from the market, and the commercial microdialysis probes have the following defects:
1. the price of the commodity microdialysis probe is expensive and can only be used for 1 to 2 times, thus greatly hindering the popularization and application of the technology.
2. The pore size of the dialysis membrane of the commercial microdialysis probe is fixed, and only compounds with related molecular weights can be dialyzed.
3. The effective dialysis area of the commodity microdialysis probe is fixed, and the requirement on detection equipment is high.
SUMMERY OF THE UTILITY MODEL
The utility model discloses to above-mentioned problem, compensate prior art not enough, provide an experimental animals microdialysis probe. The utility model discloses the shortcoming of commodity probe has been solved from above three aspect, has realized: 1. the probe dialysis membrane area is replaced for repeated use; 2. changing dialysis membranes with different properties to expand the range of compounds that can be collected; 3. the length of the dialysis membrane can be adjusted, the recovery rate is improved, and the limitation of the detector on the sensitivity is compensated.
In order to achieve the above purpose, the utility model adopts the following technical scheme.
The utility model relates to an experimental animals microdialysis probe, its characterized in that: the device comprises a first fused capillary silicon tube, a second fused capillary silicon tube, a hollow cellulose dialysis membrane, a microdialysis main body part, an intermediate connection part, a sample output unit and a sample introduction unit; the hollow cellulose dialysis membrane is connected to one end of the microdialysis main body part, the other end of the microdialysis main body part is connected with one end of the middle connecting part, and the other end of the middle connecting part is respectively connected with the sample output unit and the sample introduction unit; the first fused capillary silicon tube passes through the hollow cellulose dialysis membrane, the microdialysis main body part, the middle connecting part and the sample output unit, and the second fused capillary silicon tube passes through the hollow cellulose dialysis membrane, the microdialysis main body part, the middle connecting part and the sample injection unit.
As a preferred scheme of the utility model, the first melting capillary silicon tube is a 25cm melting capillary silicon tube, and the second melting capillary silicon tube is a 30cm melting capillary silicon tube; the front end of a 30cm fused capillary silicon tube positioned at one end in the hollow cellulose dialysis membrane exceeds the front end of a 25cm short fused capillary silicon tube by 2mm, and the two fused capillary silicon tubes are fixedly connected together by glue at a position which is about 4cm-5cm away from the 30cm fused capillary silicon tube.
As another preferred scheme of the utility model, the both ends of hollow cellulose dialysis membrane are the opening, and the PC that the one end opening part passes through 0.2mm thickness is glued and is sealed, and hollow cellulose dialysis membrane cup joints in the front portion of two melting capillary silicon tubes through other end opening, and the front end of melting capillary silicon tube does not touch hollow cellulose dialysis membrane.
As another preferred scheme of the present invention, the microdialysis main body part comprises a first stainless steel metal sleeve, a second stainless steel metal sleeve and a first rubber tube, wherein the first stainless steel metal sleeve is a 17mm stainless steel metal sleeve, the second stainless steel metal sleeve is a 8mm stainless steel metal sleeve, and the first rubber tube is a 13cm rubber tube; after being sleeved outside the fused capillary silicon tube, the hollow cellulose dialysis membrane is not contacted with the front end of the 17mm stainless steel metal sleeve, and a PC glue layer is coated from the front end of the 17mm stainless steel metal sleeve to the hollow cellulose dialysis membrane except for a 2mm effective region; the 8mm stainless steel metal sleeve is inserted in one port of the 13cm rubber tube, the joint of the 8mm stainless steel metal sleeve is fixed through glue, and the other end of the 17mm stainless steel metal sleeve penetrates through the 8mm stainless steel metal sleeve and is inserted in the 13cm rubber tube, and the joint of the 17mm stainless steel metal sleeve is fixed through glue.
The stainless steel pipe is inserted into one port of the 17mm stainless steel metal sleeve, the joint of the stainless steel pipe is fixed through PC glue, the other port of the 17mm stainless steel metal sleeve is inserted into one port of the 13cm rubber pipe, the joint of the stainless steel pipe is fixed through glue, and the stainless steel pipe is sleeved outside the 17mm stainless steel metal sleeve, and the joint of the stainless steel pipe is fixed through glue.
As another preferred scheme of the utility model, 8mm stainless steel metal sleeve front end be 5mm apart from 17mm stainless steel metal sleeve, 8mm metal sleeve front end is 10.5mm apart from 30cm melting capillary silicon tube top.
As another preferred scheme of the present invention, the middle connection part comprises a first yellow gun head, a second rubber tube and a fourth rubber tube, the first yellow gun head is a 200 μ l yellow gun head, the second rubber tube is a 15cm rubber tube, and the fourth rubber tube is a 8cm rubber tube; one end of a 200 mul yellow gun head is inserted into the other port of the 13cm rubber tube, the joint is fixed by PC glue, and the other end of the 200 mul yellow gun head is respectively inserted with a 15cm rubber tube and an 8cm rubber tube.
As another preferred scheme of the present invention, the sample introduction unit includes a third stainless steel metal sleeve, a fourth stainless steel metal sleeve, and a third rubber tube, the third stainless steel metal sleeve is a 15mm stainless steel metal sleeve, the fourth stainless steel metal sleeve is a 6mm stainless steel metal sleeve, and the third rubber tube is a 2cm rubber tube; one end of the 6mm stainless steel metal sleeve is inserted into the 15cm rubber tube, the other end of the 6mm stainless steel metal sleeve is inserted into the 2cm rubber tube, the joint is fixed through PC glue, the 15mm stainless steel metal sleeve is inserted into the 6mm stainless steel metal sleeve, the joint is fixed through glue, one end of the 15mm stainless steel metal sleeve is inserted into the 15cm rubber tube, the other end of the 15mm stainless steel metal sleeve is inserted into the 2cm rubber tube, and the joint is fixed through PC glue.
As another preferred scheme of the utility model, the sample output unit comprises a second yellow gun head and an EP tube, and the second yellow gun head is a 200 μ l yellow gun head; one end of a 200 mul yellow gun head is inserted into the other end of the 8cm rubber tube, and the other end of the 200 mul yellow gun head is connected with the EP tube and fixed by a thin adhesive tape.
Compared with the prior art, the beneficial effects of the utility model.
The utility model provides an experimental animals microdialysis probe has following 6 big characteristics.
(1) The inner diameter of the fused capillary silicon tube is small, the tissue damage is small, and the detected tissue function is relatively complete.
(2) Recovery rate is basically consistent with the literature report, performance is stable, and effectiveness of continuous or discontinuous sampling is ensured.
(3) The effective dialysis area can be changed and adjusted according to the requirement.
(4) The dialysis membrane is replaceable and the substance to be detected is defined in a targeted manner.
(5) The volume of a molten capillary silicon tube dead cavity is small, and the collected sample has real-time performance.
(6) The raw materials are easy to obtain, the manufacturing cost is obviously reduced, and the method has the popularization.
The utility model discloses a: 1. the probe dialysis membrane area is replaced for repeated use; 2. changing dialysis membranes with different properties to expand the range of compounds that can be collected; 3. the length of the dialysis membrane can be adjusted, the recovery rate is improved, and the limitation of the detector on the sensitivity is compensated.
Drawings
In order to make the technical problem, technical scheme and beneficial effect that the utility model solved more clearly understand, it is right to combine the attached drawing and detailed description mode below the utility model discloses further detailed description. It should be understood that the detailed description and specific examples, while indicating the invention, are given by way of illustration only.
FIG. 1 is a schematic structural diagram of a microdialysis probe for laboratory animals according to the present invention.
The labels in the figure are: 1. a hollow cellulose dialysis membrane; 2, PC glue layer; 3. a first fused capillary silicon tube; 4. a second fused capillary silicon tube; 5. a first stainless steel metal sleeve; 6. a second stainless steel metal sleeve; 7. a first rubber tube; 8. a first yellow gun head; 9. a second rubber tube; 10. a third stainless steel metal sleeve; 11. a fourth stainless steel metal sleeve; 12. a third rubber tube; 13. a fourth rubber tube; 14. a second yellow gun head; an EP tube.
Detailed Description
With reference to the attached figure 1, the utility model relates to an experimental animal microdialysis probe, which comprises a first fused capillary silicon tube 3, a second fused capillary silicon tube 4, a hollow cellulose dialysis membrane 1, a microdialysis main body part, a middle connection part, a sample output unit and a sample introduction unit; the hollow cellulose dialysis membrane 1 is connected with one end of a microdialysis main body part, the other end of the microdialysis main body part is connected with one end of a middle connecting part, and the other end of the middle connecting part is respectively connected with a sample output unit and a sample introduction unit; the first fused capillary silicon tube 3 passes through the hollow cellulose dialysis membrane 1, the microdialysis main body part, the middle connecting part and the sample output unit, and the second fused capillary silicon tube 4 passes through the hollow cellulose dialysis membrane 1, the microdialysis main body part, the middle connecting part and the sample injection unit.
The first melting capillary silicon tube 3 is a 25cm melting capillary silicon tube, and the second melting capillary silicon tube 4 is a 30cm melting capillary silicon tube; the front end of a 30cm fused capillary silicon tube positioned at one end in the hollow cellulose dialysis membrane 1 exceeds the front end of a 25cm short fused capillary silicon tube by 2mm, and the two fused capillary silicon tubes are fixedly connected together by glue at a position which is about 4cm-5cm away from the 30cm fused capillary silicon tube.
The two ends of the hollow cellulose dialysis membrane 1 are provided with openings, the opening at one end is sealed by PC glue with the thickness of 0.2mm, the hollow cellulose dialysis membrane 1 is sleeved at the front parts of the two molten capillary silicon tubes through the opening at the other end, and the front end of the molten capillary silicon tube does not touch the hollow cellulose dialysis membrane 1.
The microdialysis main body part comprises a first stainless steel metal sleeve 5, a second stainless steel metal sleeve 6 and a first rubber tube 7, wherein the first stainless steel metal sleeve 5 is a 17mm stainless steel metal sleeve, the second stainless steel metal sleeve 6 is an 8mm stainless steel metal sleeve, and the first rubber tube 7 is a 13cm rubber tube; the hollow cellulose dialysis membrane 1 is sleeved outside the fused capillary silicon tube and then is not contacted with the front end of the 17mm stainless steel metal sleeve, and a PC glue layer 2 is coated from the front end of the 17mm stainless steel metal sleeve to the hollow cellulose dialysis membrane 1 except for the 2mm effective region; the 8mm stainless steel metal sleeve is inserted in one port of the 13cm rubber tube, the joint of the 8mm stainless steel metal sleeve is fixed through glue, and the other end of the 17mm stainless steel metal sleeve penetrates through the 8mm stainless steel metal sleeve and is inserted in the 13cm rubber tube, and the joint of the 17mm stainless steel metal sleeve is fixed through glue.
The distance between the front end of the 8mm stainless steel metal sleeve and the front end of the 17mm stainless steel metal sleeve is 5mm, and the distance between the front end of the 8mm metal sleeve and the top end of the 30cm fused capillary silicon tube is 10.5 mm.
The middle connecting part comprises a first yellow gun head 8, a second rubber tube 9 and a fourth rubber tube 13, wherein the first yellow gun head 8 is a 200 mu l yellow gun head, the second rubber tube 9 is a 15cm rubber tube, and the fourth rubber tube 13 is an 8cm rubber tube; one end of a 200 mul yellow gun head is inserted into the other port of the 13cm rubber tube, the joint is fixed by glue, and the other end of the 200 mul yellow gun head is respectively inserted with a 15cm rubber tube and an 8cm rubber tube.
The sample introduction unit comprises a third stainless steel metal sleeve 10, a fourth stainless steel metal sleeve 11 and a third rubber tube 12, wherein the third stainless steel metal sleeve 10 is a 15mm stainless steel metal sleeve, the fourth stainless steel metal sleeve 11 is a 6mm stainless steel metal sleeve, and the third rubber tube 12 is a 2cm rubber tube; one end of the 6mm stainless steel metal sleeve is inserted into the 15cm rubber tube, the other end of the 6mm stainless steel metal sleeve is inserted into the 2cm rubber tube, the joint is fixed through PC glue, the 15mm stainless steel metal sleeve is inserted into the 6mm stainless steel metal sleeve, the joint is fixed through glue, one end of the 15mm stainless steel metal sleeve is inserted into the 15cm rubber tube, the other end of the 15mm stainless steel metal sleeve is inserted into the 2cm rubber tube, and the joint is fixed through PC glue.
The sample output unit comprises a second yellow gun head 14 and an EP (EP) tube 15, wherein the second yellow gun head 14 is a 200-microliter yellow gun head; one end of a 200 mul yellow gun head is inserted into the other end of the 8cm rubber tube, and the other end of the 200 mul yellow gun head is connected with the EP tube 15 and fixed by a thin adhesive tape.
Combine the technical scheme and the attached drawing of the utility model to explain the utility model discloses a manufacturing process.
Materials required for preparation: high power microscope, hollow cellulose dialysis membrane (ID =40 μm, OD =105 μm), one each of 25cm, 30cm fused capillary silicon tubes (ID =200 μm, OD =216 μm), one each of 2cm, 8cm, 13cm, 15cm rubber tubes, several 6mm, 8mm, 15mm and 17mm stainless steel metal sleeves, several 200 μ l yellow tips, venens direct shear, EP tubes, PC glue, fine tape, 502 glue.
1. Preparation of dialysis membranes
The transparent fine adhesive tape is rolled and adhered on a glass slide, one end of the dialysis membrane is fixed on the adhesive tape, a proper length is cut off by a Venus direct shear, PC glue enters about 0.2mm under a microscope due to the siphon action to seal the opening of the dialysis membrane, and the dialysis membrane is placed in a dry and closed container for 24 hours.
2. Preparation of melting capillary silicon tube
Inspecting two ends of the fused capillary silicon tube under a microscope to ensure that the tail end is regular and has no fragments; fixing 30cm long fused capillary silicon tube 2mm (effective area length for probe dialysis is 1.8 mm) above 25cm short fused capillary silicon tube with glue at a distance of 4-5 cm from long silicon tube, and drying for 10 min.
3. Preparation of microdialysis body part
Two fixed melting capillary silicon tubes penetrate into a 13cm rubber tube, an 8mm stainless steel metal sleeve is fixed into the rubber tube, a 17mm stainless steel metal sleeve penetrates into the 8mm stainless steel metal sleeve and reaches the inside of the 13cm rubber tube, so that the distance between the front end of the 8mm metal sleeve and the 17mm metal sleeve is 5mm, the distance between the front end of the 8mm metal sleeve and the top end of the long melting capillary silicon tube is 10.5mm, the front end of each connecting part is fixed by glue, and the drying is carried out for 10 min.
4. Preparation of intermediate connecting part
Cutting 200 μ l of yellow gun head to suitable size, inserting 13cm rubber tube at the tip of the cut, inserting 8cm and 15cm rubber tube at the end of the cut, fixing with glue, and drying for 10 min.
5. Preparation of sample introduction unit
Inserting a stainless steel sleeve of 15mm into a stainless steel sleeve of 6mm, fixing the joint with glue to form a whole, and drying for 10 min.
The tail end of a 30cm fused capillary silicon tube penetrates into a 6mm stainless steel metal sleeve and is fixed in a 15cm rubber tube, a long fused capillary silicon tube extends out by about 1cm, the tail end of the fused capillary silicon tube is protected by a 2cm rubber tube, joints are fixed by PC glue, and drying is carried out for 24 hours.
6. Prepared sample output unit
Cutting 200 μ l of yellow gun head to suitable size, inserting the cut tip into 8cm rubber tube to make the short fused capillary silicon tube extend out by about 5cm, placing EP tube at the end of the cut to protect the fused capillary silicon tube, and fixing the end of the fused capillary silicon tube with thin adhesive tape.
7. Connecting dialysis membrane
Sleeving the prepared dialysis membrane into the front ends of 25cm and 30cm molten capillary silicon tubes to ensure that the front ends of the molten capillary silicon tubes do not touch the dialysis membrane, fixing by using PC glue, and drying for 24 hours.
It should be understood that the above detailed description of the present invention is only for illustrating the present invention and is not limited by the technical solutions described in the embodiments of the present invention, and those skilled in the art should understand that the present invention can still be modified or equivalently replaced to achieve the same technical effects; as long as the use requirement is satisfied, the utility model is within the protection scope.
Claims (8)
1. An experimental animal microdialysis probe, which is characterized in that: the device comprises a first fused capillary silicon tube, a second fused capillary silicon tube, a hollow cellulose dialysis membrane, a microdialysis main body part, an intermediate connection part, a sample output unit and a sample introduction unit; the hollow cellulose dialysis membrane is connected to one end of the microdialysis main body part, the other end of the microdialysis main body part is connected with one end of the middle connecting part, and the other end of the middle connecting part is respectively connected with the sample output unit and the sample introduction unit; the first fused capillary silicon tube passes through the hollow cellulose dialysis membrane, the microdialysis main body part, the middle connecting part and the sample output unit, and the second fused capillary silicon tube passes through the hollow cellulose dialysis membrane, the microdialysis main body part, the middle connecting part and the sample injection unit.
2. The microdialysis probe for laboratory animals according to claim 1, characterized by: the first melting capillary silicon tube is a 25cm melting capillary silicon tube, and the second melting capillary silicon tube is a 30cm melting capillary silicon tube; the front end of a 30cm fused capillary silicon tube positioned at one end in the hollow cellulose dialysis membrane exceeds the front end of a 25cm short fused capillary silicon tube by 2mm, and the two fused capillary silicon tubes are fixedly connected together by glue at a position which is about 4cm-5cm away from the 30cm fused capillary silicon tube.
3. The microdialysis probe for laboratory animals according to claim 1, characterized by: the both ends of hollow cellulose dialysis membrane are the opening, and one end opening part seals through the PC of 0.2mm thickness is glued, and hollow cellulose dialysis membrane cup joints in the front portion of two melting capillary silicon tubes through the other end opening, and the front end of melting capillary silicon tube does not touch hollow cellulose dialysis membrane.
4. The microdialysis probe for laboratory animals according to claim 1, characterized by: the microdialysis main body part comprises a first stainless steel metal sleeve, a second stainless steel metal sleeve and a first rubber tube, wherein the first stainless steel metal sleeve is a 17mm stainless steel metal sleeve, the second stainless steel metal sleeve is an 8mm stainless steel metal sleeve, and the first rubber tube is a 13cm rubber tube; after being sleeved outside the fused capillary silicon tube, the hollow cellulose dialysis membrane is not contacted with the front end of the 17mm stainless steel metal sleeve, and a PC glue layer is coated from the front end of the 17mm stainless steel metal sleeve to the hollow cellulose dialysis membrane except for a 2mm effective region; the 8mm stainless steel metal sleeve is inserted in one port of the 13cm rubber tube, the joint of the 8mm stainless steel metal sleeve is fixed through glue, and the other end of the 17mm stainless steel metal sleeve penetrates through the 8mm stainless steel metal sleeve and is inserted in the 13cm rubber tube, and the joint of the 17mm stainless steel metal sleeve is fixed through glue.
5. The microdialysis probe for laboratory animals according to claim 4, characterized by the fact that: the distance between the front end of the 8mm stainless steel metal sleeve and the front end of the 17mm stainless steel metal sleeve is 5mm, and the distance between the front end of the 8mm metal sleeve and the top end of the 30cm fused capillary silicon tube is 10.5 mm.
6. The microdialysis probe for laboratory animals according to claim 1, characterized by: the middle connecting part comprises a first yellow gun head, a second rubber tube and a fourth rubber tube, wherein the first yellow gun head is a 200 mu l yellow gun head, the second rubber tube is a 15cm rubber tube, and the fourth rubber tube is an 8cm rubber tube; one end of a 200 mul yellow gun head is inserted into the other port of the 13cm rubber tube, the joint is fixed by PC glue, and the other end of the 200 mul yellow gun head is respectively inserted with a 15cm rubber tube and an 8cm rubber tube.
7. The microdialysis probe for laboratory animals according to claim 1, characterized by: the sample introduction unit comprises a third stainless steel metal sleeve, a fourth stainless steel metal sleeve and a third rubber tube, wherein the third stainless steel metal sleeve is a 15mm stainless steel metal sleeve, the fourth stainless steel metal sleeve is a 6mm stainless steel metal sleeve, and the third rubber tube is a 2cm rubber tube; one end of the 6mm stainless steel metal sleeve is inserted into the 15cm rubber tube, the other end of the 6mm stainless steel metal sleeve is inserted into the 2cm rubber tube, the joint is fixed through PC glue, the 15mm stainless steel metal sleeve is inserted into the 6mm stainless steel metal sleeve, the joint is fixed through glue, one end of the 15mm stainless steel metal sleeve is inserted into the 15cm rubber tube, the other end of the 15mm stainless steel metal sleeve is inserted into the 2cm rubber tube, and the joint is fixed through PC glue.
8. The microdialysis probe for laboratory animals according to claim 1, characterized by: the sample output unit comprises a second yellow gun head and an EP (EP) tube, wherein the second yellow gun head is a 200-microliter yellow gun head; one end of a 200 mul yellow gun head is inserted into the other end of the 8cm rubber tube, and the other end of the 200 mul yellow gun head is connected with the EP tube and fixed by a thin adhesive tape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921110064.1U CN210697699U (en) | 2019-07-16 | 2019-07-16 | Experimental animal microdialysis probe |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201921110064.1U CN210697699U (en) | 2019-07-16 | 2019-07-16 | Experimental animal microdialysis probe |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210697699U true CN210697699U (en) | 2020-06-09 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201921110064.1U Expired - Fee Related CN210697699U (en) | 2019-07-16 | 2019-07-16 | Experimental animal microdialysis probe |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210697699U (en) |
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2019
- 2019-07-16 CN CN201921110064.1U patent/CN210697699U/en not_active Expired - Fee Related
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| CF01 | Termination of patent right due to non-payment of annual fee |