CN215078895U - Saliva collection system based on micro-fluidic chip technique - Google Patents

Saliva collection system based on micro-fluidic chip technique Download PDF

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CN215078895U
CN215078895U CN202022294513.1U CN202022294513U CN215078895U CN 215078895 U CN215078895 U CN 215078895U CN 202022294513 U CN202022294513 U CN 202022294513U CN 215078895 U CN215078895 U CN 215078895U
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saliva
liquid outlet
collector
device based
sampler
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CN202022294513.1U
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陈怡萍
陈柯瑾
金伟正
卢林鑫
梁培
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China Jiliang University
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China Jiliang University
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Abstract

The utility model discloses a saliva collecting device based on the micro-fluidic chip technology, which comprises a saliva collecting chip and a saliva detecting sheet; the saliva sampler is in a round hole shape and extends into the oral cavity for saliva collection; a main channel pipe with a filter layer and a micro pump penetrates through the saliva collecting chip and is communicated with the saliva sampler and the liquid outlet; and (3) placing the saliva detection sheet in a clamping groove, enabling the saliva to flow into a liquid storage groove, and naturally drying and crystallizing. The utility model discloses the device can be directly conveniently taken a sample from the oral cavity effectively, avoids receiving the destruction and the pollution of foreign matter among the sampling process, can let the saliva sample natural drying under the relative confined environment of micro-fluidic chip. The device has simple technical structure, convenient collection and operation process, disposable design and sanitation and safety.

Description

Saliva collection system based on micro-fluidic chip technique
Technical Field
The utility model relates to a body fluid collection technology field especially relates to a saliva collection system based on micro-fluidic chip technique.
Background
Human saliva is a complex mixture of up to over 1100 proteins in saliva alone, essentially identical to those in blood, which reflects changes in the levels of various proteins in blood. Saliva has many characteristics superior to blood and urine, such as simple and convenient collection, safety, easy acceptance by a collector and the like, and is one of the samples frequently adopted in scientific research. The saliva is helpful to diagnose some diseases, evaluate the physiological function of the organism and monitor the drug level by detecting and analyzing the saliva components, and also can help to analyze and judge the genetic characteristics of the organism by detecting and analyzing the genetic materials contained in the saliva, so the saliva is increasingly valued and widely applied in the fields of clinical examination and scientific research. The saliva collector is the main instrument of collection saliva sample, and saliva collection device has been used widely in the medical health market at present. There are many saliva collecting devices on the market, some of which use urine cups or disposable cups as containers, but these containers have a large caliber, are difficult to seal, and are prone to contamination of saliva samples. Some of the devices adopt a funnel and a collection tube mode, saliva samples are collected independently firstly, and then the saliva samples are processed, so that inconvenience is brought to operators.
SUMMERY OF THE UTILITY MODEL
To the above-mentioned problem that exists among the prior art, the utility model aims to provide a saliva collection system based on micro-fluidic chip technique. The device aims to directly, conveniently and effectively sample from the oral cavity, avoid the damage and pollution of external substances in the sampling process, and naturally dry the saliva sample in the closed environment of the microfluidic chip.
For solving the above problem, the utility model adopts the following technical scheme:
a saliva collecting device based on a microfluidic chip technology comprises a saliva collector (1) and a saliva detecting sheet (2); wherein the saliva collector (1) comprises a saliva sampler (101), a main channel tube (102), a filter layer (103), a micro pump (104), a liquid outlet (105) and a clamping groove (106), and the saliva detection sheet (2) comprises a liquid storage tank (201); the filter layer (103) is positioned at 8mm of the right side of the saliva sampler (101), the micro pump (104) is positioned at 8mm of the right side of the filter layer (103), the liquid outlet (105) is positioned at the right side of the micro pump (104), the saliva sampler (101), the filter layer (103), the micro pump (104) and the liquid outlet (105) are positioned in the same linear direction and penetrated through by the main channel tube (102), and the clamping groove (106) is positioned under the liquid outlet (105); the liquid outlet (105) penetrates through the upper layer of the saliva collector (1), and when the saliva detection sheet (2) is inserted into the clamping groove (106), saliva flows into the liquid storage groove (201) from the liquid outlet (105); the saliva collector (1) and the saliva detection sheet (2) are made of polymethyl methacrylate (PMMA) and have the width of 20mm, the end of a saliva sampler (101) in the saliva collector (1) is in the shape of a round rod, the diameter of the saliva sampler (101) is 5mm, the thickness of the saliva collector (1) is 5mm, the thickness of the upper layer and the lower layer of the saliva collector (1) is 1.5mm, the height of the saliva detection sheet (2) and the clamping groove (106) is 2mm, the length of the main channel tube (102) is 30mm, the width is 30 mu m, the diameter of the liquid outlet (105) is 4mm, the diameter of the liquid storage tank (201) is 5mm, and the depth is 1 mm; the filter layer (103) utilizes activated carbon to simply filter saliva; the main channel tube (102) makes saliva flow by using a capillary principle, and the micro pump (104) continuously conveys the saliva to the liquid outlet (105) and into the liquid storage tank (201) by using a fluid characteristic.
The saliva collector (1) and the saliva detection sheet (2) are made of plastics.
The technical scheme has the following beneficial effects:
1. the device can be used for directly, conveniently and effectively sampling from the oral cavity, so that the damage and the pollution of external substances in the sampling process are avoided, and the reliability of a detection result is improved.
2. By adopting the device, the saliva sample can be naturally dried and crystallized in the closed environment of the microfluidic chip, and the probability of sample pollution in the air-drying crystallization process is reduced.
3. By adopting the micro-fluidic chip technology, the required detected samples are very few in demand, the detection is convenient, and the micro-fluidic chip is easily accepted by the public.
Drawings
The present invention will be further described with reference to the accompanying drawings and the detailed description.
FIG. 1 is a view of a saliva collector;
FIG. 2 is a view showing the structure of a saliva test piece;
in the figure, 1 is a saliva collector, 2 is a saliva detection sheet, 101 is a saliva sampler, 102 is a main channel tube, 103 is a filter layer, 104 is a micro pump, 105 is a liquid outlet, 106 is a clamping groove, and 201 is a liquid storage groove.
Detailed Description
In fig. 1 and 2, a saliva collecting device based on the microfluidic chip technology: comprises a saliva collector 1 and a saliva detecting sheet 2; wherein the saliva collector 1 comprises a saliva sampler 101, a main channel tube 102, a filter layer 103, a micro pump 104, a liquid outlet 105 and a clamping groove 106, and the saliva detection sheet 2 comprises a liquid storage tank 201; the filter layer 103 is positioned 8mm on the right side of the saliva sampler 101, the micro pump 104 is positioned 8mm on the right side of the filter layer 103, the liquid outlet 105 is positioned on the right side of the micro pump 104, the saliva sampler 101, the filter layer 103, the micro pump 104 and the liquid outlet 105 are in the same linear direction and are penetrated through by the main channel tube 102, and the clamping groove 106 is positioned right below the liquid outlet 105; the liquid outlet 105 penetrates through the upper layer of the saliva collector 1, and when the saliva detection sheet 2 is inserted into the clamping groove 106, saliva flows into the liquid storage tank 201 from the liquid outlet 105; the saliva collector 1 and the saliva detection sheet 2 are made of polymethyl methacrylate (PMMA), the width is 20mm, the end of a saliva sampler 101 in the saliva collector 1 is in a round rod shape, the diameter of the saliva sampler 101 is 5mm, the thickness of the saliva collector 1 is 5mm, the thickness of an upper layer and a lower layer of the saliva collector 1 is 1.5mm, the height of the saliva detection sheet 2 and a clamping groove 106 is 2mm, the length of a main channel tube 102 is 30mm, the width is 30 mu m, the diameter of a liquid outlet 105 is 4mm, the diameter of a liquid storage tank 201 is 5mm, and the depth is 1 mm; the filter layer 103 uses active carbon to simply filter saliva; the main channel tube 102 uses the capillary principle to flow saliva, and the micro-pump 104 uses the fluid property to continuously deliver the saliva to the outlet 105 and into the reservoir 201.
A saliva collection system working process based on micro-fluidic chip technology: a saliva collecting device based on a microfluidic chip technology is connected according to the structure shown in figure 1, a saliva detecting sheet 2 is fixed in a clamping groove 106 of a saliva collector 1, and a liquid storage tank 201 of the saliva detecting sheet 2 is positioned under a liquid outlet 105 of the saliva collector 1. The saliva sampler 101 of the saliva collector 1 extends into the oral cavity to collect saliva, the saliva sampler is horizontally placed on a table top, the device is placed for 5-10 minutes to naturally dry and crystallize, the saliva flows from the saliva sampler 101 of the saliva collector 1 to the filter layer 103 through the main channel tube 102 under the capillary action, the filter layer 103 uses active carbon to simply filter the saliva and flows to the micro pump 104 through the main channel tube 102 under the capillary action, the micro pump 104 continuously conveys the saliva to the liquid outlet 105 by using the fluid characteristic and flows into the liquid storage tank 201, the saliva completes the natural drying and crystallization process in the liquid storage tank 201 of the saliva detection sheet 2, and the whole process is carried out in a relatively closed micro-fluidic chip environment, so that the damage and the pollution of external substances are avoided. Taking the saliva detection piece 2 with crystals out of the clamping groove 106 of the saliva collector 1, putting the saliva detection piece into a handheld ovulation period detector, and carrying out image acquisition and algorithm analysis on the saliva crystals by using image acquisition systems such as a camera, an optical microscope module and an illumination light source in the instrument.

Claims (9)

1. A saliva collecting device based on a microfluidic chip technology comprises a saliva collector (1) and a saliva detecting sheet (2); the saliva sampler is characterized in that the saliva sampler (1) comprises a saliva sampler (101), a main channel tube (102), a filter layer (103), a micro pump (104), a liquid outlet (105) and a clamping groove (106), and the saliva detection sheet (2) comprises a liquid storage groove (201).
2. The saliva collecting device based on the microfluidic chip technology as claimed in claim 1, wherein the width of the saliva collector (1) and the saliva detecting sheet (2) is 20mm, the diameter of the saliva collector (101) is 5mm, the thickness of the saliva collector (1) is 5mm, the thickness of the upper layer and the lower layer of the saliva collector (1) is 1.5mm, the height of the saliva detecting sheet (2) and the clamping groove (106) is 2mm, the length of the main channel tube (102) is 30mm, the width of the main channel tube is 30 μm, the diameter of the liquid outlet (105) is 4mm, the diameter of the liquid storage tank (201) is 5mm, and the depth of the liquid storage tank is 1 mm.
3. A saliva collecting device based on microfluidic chip technology according to claim 1, wherein the saliva sampler (101), the filter layer (103), the micro pump (104) and the liquid outlet (105) are in the same linear direction and are penetrated by the main channel tube (102).
4. The saliva collecting device based on the microfluidic chip technology as claimed in claim 1, wherein the saliva sampler (101) end of the saliva collector (1) is round rod-shaped.
5. The saliva collecting device based on the microfluidic chip technology as claimed in claim 1, wherein the filter layer (103) is located 8mm on the right side of the saliva sampler (101), the micro pump (104) is located 8mm on the right side of the filter layer (103), the liquid outlet (105) is located on the right side of the micro pump (104), and the clamping groove (106) is located right below the liquid outlet (105).
6. The saliva collecting device based on the microfluidic chip technology as claimed in claim 1, wherein the liquid outlet (105) penetrates through the upper layer of the saliva collector (1), and when the saliva detecting sheet (2) is inserted into the slot (106), the saliva flows into the reservoir (201) from the liquid outlet (105).
7. A saliva collecting device based on microfluidic chip technology according to claim 1, wherein the saliva collector (1) and the saliva detecting piece (2) are polymethyl methacrylate (PMMA).
8. A saliva collecting device based on microfluidic chip technology according to claim 1, characterized in that the filter layer (103) uses activated carbon to simply filter the saliva.
9. A saliva collecting device based on microfluidic chip technology according to claim 1, characterized in that the main channel tube (102) uses capillary principle to make saliva flow, and the micro pump (104) uses fluid property to continuously convey saliva to the liquid outlet (105) and into the liquid storage tank (201).
CN202022294513.1U 2020-10-15 2020-10-15 Saliva collection system based on micro-fluidic chip technique Active CN215078895U (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202022294513.1U CN215078895U (en) 2020-10-15 2020-10-15 Saliva collection system based on micro-fluidic chip technique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202022294513.1U CN215078895U (en) 2020-10-15 2020-10-15 Saliva collection system based on micro-fluidic chip technique

Publications (1)

Publication Number Publication Date
CN215078895U true CN215078895U (en) 2021-12-10

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CN (1) CN215078895U (en)

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