CN210193854U - Fixed bed reactor for biological artificial liver - Google Patents
Fixed bed reactor for biological artificial liver Download PDFInfo
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- CN210193854U CN210193854U CN201920900584.6U CN201920900584U CN210193854U CN 210193854 U CN210193854 U CN 210193854U CN 201920900584 U CN201920900584 U CN 201920900584U CN 210193854 U CN210193854 U CN 210193854U
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Abstract
The utility model provides a fixed bed reactor for a biological artificial liver, which comprises a reactor and a lifting mechanism, wherein the reactor is fixed on the lifting mechanism; a rotary stirring unit and a lifting stirring unit are arranged in the reactor, the lifting stirring unit is positioned outside the rotary stirring unit, and the lifting stirring unit is connected with the lifting mechanism; the lifting stirring unit comprises 2 lifting rods and a plurality of lifting stirring components, and the lifting stirring components are fixed on the lifting rods. A fixed bed reactor for biotype artificial liver pass through elevating system and drive the lift stirring unit and carry out fore-and-aft stirring, combine rotatory stirring unit to carry out horizontal stirring, in the reactor, can make the thallus in oxygen and the feed liquid fully fuse, fermentation efficiency is high, the homogeneity of feed liquid and air mixing has been guaranteed to the increase stirring area.
Description
Technical Field
The utility model belongs to the technical field of biotechnology equipment, especially, relate to a fixed bed reactor for biological type artificial liver.
Background
The artificial liver is a device which is used for removing various harmful substances generated or increased due to liver failure by means of an in-vitro mechanical, physicochemical or biological reactor, supplementing necessary substances such as proteins required to be synthesized or metabolized by the liver and the like, improving internal environments such as water, electrolyte, acid-base balance and the like of a patient, temporarily assisting or replacing corresponding main functions of the liver until autologous hepatocytes are regenerated and liver functions are recovered, or improving symptoms of a patient with late-stage liver diseases to become a 'bridge' for liver transplantation, and improving the survival rate of the patient. Referred to as "artificial liver".
Liver failure is a serious stage of the development of various liver diseases, has high fatality rate, and has no effective treatment method at present. Artificial liver support systems are one of the important methods for treating liver failure, and include non-biological artificial liver, and mixed artificial liver. At present, the biological artificial liver is an artificial liver device which is closest to the detoxification, synthesis and metabolism functions of human liver. Due to the complex liver function, the biological artificial liver faces a great challenge in the screening of seed cells, the construction of a bioreactor and the optimal combination of the bioreactor and an auxiliary device, and the development of the biological artificial liver is slow.
Bioreactor refers to any manufacturing or engineering device that provides a biologically active environment. In one case, a bioreactor is a vessel that performs a chemical process involving the production of biologically or biochemically active substances from a particular organism. This process can be carried out either aerobically or anaerobically. These bioreactors, which are generally cylindrical, vary in volume from a few liters to several cubic meters, are often made of stainless steel, and the cell culture is also called cell cloning technology, which is the normal term in biology for cell culture technology. Cell culture is an essential process for both the whole bioengineering technique and one of the biological cloning techniques, and is itself a large-scale cloning of cells. The cell culture technology can be used for culturing a single cell into simple single cells or cells with few differentiation in a large scale, which is an indispensable link of the cloning technology, and the cell culture is the cloning of the cell. A large number of cells or their metabolites are obtained by cell culture. Since biological products are all derived from cells, it can be said that cell culture technology is the most core and basic technology in biotechnology.
In the prior art, cell cultures need to be effectively mixed through high stirring rotating speed, dissolved oxygen is increased, but shearing force generated by stirring slurry under the condition of high rotating speed can cause serious damage to cells, cell culture failure is easily caused, and simultaneously generated bubbles can cause cell damage and even death in cell culture solution.
Disclosure of Invention
In view of this, the present invention is directed to a fixed bed reactor for a biotype artificial liver, which has the characteristics of simple structure and high cell culture efficiency.
A fixed bed reactor for a biological artificial liver comprises a reactor and a lifting mechanism, wherein the reactor is fixed on the lifting mechanism;
a rotary stirring unit and a lifting stirring unit are arranged in the reactor, the lifting stirring unit is positioned outside the rotary stirring unit, and the lifting stirring unit is connected with the lifting mechanism;
the lifting stirring unit comprises 2 lifting rods and a plurality of lifting stirring components, and the lifting stirring components are all fixed on the lifting rods;
the lifting stirring assembly comprises a horizontal frame and a stirring ring, the stirring ring is of a circular structure and is fixed on the horizontal frame, two ends of the horizontal frame are respectively connected with the lifting rod, and the bottom end of the lifting rod penetrates through the reactor and is connected with the lifting mechanism;
the lifting mechanism comprises a lifting support frame, a sliding block, a driving eccentric gear, an eccentric shaft, a driven gear, a fixed shaft, a horizontal rod, a fixed sleeve, a connecting piece, a second rotating motor and 2 fixed sliding rails, wherein one end of the eccentric shaft is connected with the driving eccentric gear, the other end of the eccentric shaft penetrates through the lifting support frame to be connected with the second rotating motor, the driven gear is meshed with the driving eccentric gear, a sliding groove is formed in the lifting support frame, the sliding block is arranged on the inner side of the sliding groove and matched with the sliding groove, the sliding block is connected with the driven gear through the fixed shaft, one end of the connecting piece is connected with the fixed shaft, the other end of the connecting piece is connected with the driving eccentric gear, the fixed sleeve is fixed on the driven gear, and the horizontal rod penetrates through the fixed sleeve, two ends of the lifting rod are respectively connected with the lifting rod, and the lifting rod is respectively matched with the fixed slide rail.
Furthermore, a plurality of defoaming holes are uniformly formed in the stirring ring.
Furthermore, a boss is arranged on one side of the driving eccentric gear and connected with the eccentric shaft.
Furthermore, the connecting piece include initiative external member, driven external member, connecting plate, the both ends of connecting plate respectively with initiative external member, driven external member link to each other, initiative external member overlap in the outside of boss, driven external member overlap in the outside of fixed axle.
Furthermore, the rotary stirring unit comprises a first rotary motor, a first rotary shaft and a plurality of stirring frames, one end of the first rotary shaft is connected with the first rotary motor, and the stirring frames are uniformly fixed on the first rotary shaft.
Further, the width of the stirring frame is smaller than the diameter of the inner circle of the stirring ring.
Compared with the prior art, the fixed bed reactor for the biological artificial liver has the following advantages:
(1) a fixed bed reactor for biotype artificial liver be provided with rotatory stirring unit, lift stirring unit, elevating system simultaneously, drive through elevating system and go up and down the stirring unit and carry out fore-and-aft stirring, combine rotatory stirring unit to carry out horizontal stirring, in the reactor, can make the thallus in oxygen and the feed liquid fully fuse, fermentation efficiency is high, increase stirring area, the homogeneity of feed liquid with the air mixing has been guaranteed, guarantee to provide abundant dissolved oxygen and nutrition under the lower rotational speed condition, ensure that the cell can normally metabolize, avoid causing the injury to the cell.
(2) Elevating system through initiative eccentric gear and driven gear's cooperation, make the lifter carry out elevating movement, rational in infrastructure, nimble, stable.
Drawings
The accompanying drawings, which form a part hereof, are included to provide a further understanding of the invention, and are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and together with the description serve to explain the invention without undue limitation. In the drawings:
FIG. 1 is a schematic diagram of a fixed bed reactor for a biotype artificial liver according to an embodiment of the present invention;
FIG. 2 is a schematic view of a lifting mechanism according to an embodiment of the present invention
Fig. 3 is a side view of the driving eccentric gear according to the embodiment of the present invention;
fig. 4 is a schematic view of a fixed slide rail according to an embodiment of the present invention;
fig. 5 is a schematic view of a stirring ring according to an embodiment of the present invention.
Description of reference numerals:
1-a reactor; 2-a lifting mechanism; 11-a rotary stirring unit; 12-a lifting stirring unit; 111-a first rotating electrical machine; 112-a first shaft; 113-a stirring frame; 121-a lifting rod; 122-horizontal shelf; 123-stirring ring; 124-eliminating the foam holes; 21-lifting support frame; 211-sliding grooves; 212-a slider; 22-fixed slide rail; 23-driving eccentric gear; 231-an eccentric shaft; 232-boss; 24-a driven gear; 241-a fixed shaft; 25-horizontal bar; 26-fixing a sleeve; 27-a connector; 271-active kit; 272-a slave kit; 273-connecting plate; 28-second rotating electrical machine.
Detailed Description
It should be noted that, in the present invention, the embodiments and features of the embodiments may be combined with each other without conflict.
In the description of the present invention, it is to be understood that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", and the like, indicate orientations or positional relationships based on the orientations or positional relationships shown in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore, should not be construed as limiting the present invention. Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first," "second," etc. may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless otherwise specified.
In the description of the present invention, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; can be mechanically or electrically connected; they may be connected directly or indirectly through intervening media, or they may be interconnected between two elements. The specific meaning of the above terms in the present invention can be understood by those of ordinary skill in the art through specific situations.
The present invention will be described in detail below with reference to the accompanying drawings in conjunction with embodiments.
As shown in fig. 1-4, a fixed bed reactor for a biotype artificial liver comprises a reactor and a lifting mechanism, wherein the reactor is fixed on the lifting mechanism;
a rotary stirring unit and a lifting stirring unit are arranged in the reactor, the lifting stirring unit is positioned outside the rotary stirring unit, and the lifting stirring unit is connected with the lifting mechanism;
the lifting stirring unit comprises 2 lifting rods and a plurality of lifting stirring components, and the lifting stirring components are all fixed on the lifting rods;
the lifting stirring assembly comprises a horizontal frame and a stirring ring, the stirring ring is of a circular structure and is fixed on the horizontal frame, two ends of the horizontal frame are respectively connected with the lifting rod, and the bottom end of the lifting rod penetrates through the reactor and is connected with the lifting mechanism;
the lifting mechanism comprises a lifting support frame, a sliding block, a driving eccentric gear, an eccentric shaft, a driven gear, a fixed shaft, a horizontal rod, a fixed sleeve, a connecting piece, a second rotating motor and 2 fixed sliding rails, wherein one end of the eccentric shaft is connected with the driving eccentric gear, the other end of the eccentric shaft penetrates through the lifting support frame to be connected with the second rotating motor, the driven gear is meshed with the driving eccentric gear, a sliding groove is formed in the lifting support frame, the sliding block is arranged on the inner side of the sliding groove and matched with the sliding groove, the sliding block is connected with the driven gear through the fixed shaft, one end of the connecting piece is connected with the fixed shaft, the other end of the connecting piece is connected with the driving eccentric gear, the fixed sleeve is fixed on the driven gear, and the horizontal rod penetrates through the fixed sleeve, two ends of the lifting rod are respectively connected with the lifting rod, and the lifting rod is respectively matched with the fixed slide rail.
The stirring ring is uniformly provided with a plurality of defoaming holes. Effectively get rid of the internal bubble of jar, avoid the production of bubble, ensure the normal metabolism of cell, avoid cell death to cause the energy waste.
And a boss is arranged on one side of the driving eccentric gear and connected with the eccentric shaft. The connecting piece include initiative external member, driven external member, connecting plate, the both ends of connecting plate respectively with initiative external member, driven external member link to each other, initiative external member overlap in the outside of boss, driven external member overlap in the outside of fixed axle.
The rotary stirring unit comprises a first rotating motor, a first rotating shaft and a plurality of stirring frames, one end of the first rotating shaft is connected with the first rotating motor, and the stirring frames are uniformly fixed on the first rotating shaft. The stirring ring rotates through the rotation of the first rotating motor, and the stirring effect in the horizontal interval is achieved.
The width of the stirring frame is smaller than the diameter of the inner circle of the stirring ring. The stirring frame is rotated and stirred in the stirring ring.
Rabbling mechanism is at the operation in-process, drive the rotation of initiative eccentric gear through the second rotating electrical machines, then drive the rotation of driven gear through the meshing of initiative eccentric gear and driven gear, driven gear is at the rotation in-process, the slider is fixed in on the driven gear, through the cooperation of slider and sliding tray, driven gear drives the slider and carries out horizontal migration in the sliding tray, the sliding tray also plays limiting displacement to driven gear, and simultaneously, fixed cover is fixed in on the driven gear, through the horizontal removal and the rotation of driven gear, the lifting movement of fixed cover has been driven, thereby fixed cover has driven the lifting movement of horizon bar, and then the lifter has reciprocated, driven gear and initiative eccentric gear have been connected to the connecting piece, play limiting displacement to initiative eccentric gear.
The above description is only a preferred embodiment of the present invention, and should not be taken as limiting the invention, and any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (6)
1. A fixed bed reactor for a biotype artificial liver, characterized in that: the reactor comprises a reactor and a lifting mechanism, wherein the reactor is fixed on the lifting mechanism;
a rotary stirring unit and a lifting stirring unit are arranged in the reactor, the lifting stirring unit is positioned outside the rotary stirring unit, and the lifting stirring unit is connected with the lifting mechanism;
the lifting stirring unit comprises 2 lifting rods and a plurality of lifting stirring components, and the lifting stirring components are all fixed on the lifting rods;
the lifting stirring assembly comprises a horizontal frame and a stirring ring, the stirring ring is of a circular structure and is fixed on the horizontal frame, two ends of the horizontal frame are respectively connected with the lifting rod, and the bottom end of the lifting rod penetrates through the reactor and is connected with the lifting mechanism;
the lifting mechanism comprises a lifting support frame, a sliding block, a driving eccentric gear, an eccentric shaft, a driven gear, a fixed shaft, a horizontal rod, a fixed sleeve, a connecting piece, a second rotating motor and 2 fixed sliding rails, wherein one end of the eccentric shaft is connected with the driving eccentric gear, the other end of the eccentric shaft penetrates through the lifting support frame to be connected with the second rotating motor, the driven gear is meshed with the driving eccentric gear, a sliding groove is formed in the lifting support frame, the sliding block is arranged on the inner side of the sliding groove and matched with the sliding groove, the sliding block is connected with the driven gear through the fixed shaft, one end of the connecting piece is connected with the fixed shaft, the other end of the connecting piece is connected with the driving eccentric gear, the fixed sleeve is fixed on the driven gear, and the horizontal rod penetrates through the fixed sleeve, two ends of the lifting rod are respectively connected with the lifting rod, and the lifting rod is respectively matched with the fixed slide rail.
2. The fixed bed reactor for a biotype artificial liver according to claim 1, characterized in that: the stirring ring is uniformly provided with a plurality of defoaming holes.
3. The fixed bed reactor for a biotype artificial liver according to claim 1, characterized in that: and a boss is arranged on one side of the driving eccentric gear and connected with the eccentric shaft.
4. The fixed bed reactor for a biotype artificial liver according to claim 3, characterized in that: the connecting piece include initiative external member, driven external member, connecting plate, the both ends of connecting plate respectively with initiative external member, driven external member link to each other, initiative external member overlap in the outside of boss, driven external member overlap in the outside of fixed axle.
5. The fixed bed reactor for a biotype artificial liver according to claim 1, characterized in that: the rotary stirring unit comprises a first rotating motor, a first rotating shaft and a plurality of stirring frames, one end of the first rotating shaft is connected with the first rotating motor, and the stirring frames are uniformly fixed on the first rotating shaft.
6. The fixed bed reactor for a biotype artificial liver according to claim 5, characterized in that: the width of the stirring frame is smaller than the diameter of the inner circle of the stirring ring.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920900584.6U CN210193854U (en) | 2019-06-14 | 2019-06-14 | Fixed bed reactor for biological artificial liver |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920900584.6U CN210193854U (en) | 2019-06-14 | 2019-06-14 | Fixed bed reactor for biological artificial liver |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210193854U true CN210193854U (en) | 2020-03-27 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920900584.6U Active CN210193854U (en) | 2019-06-14 | 2019-06-14 | Fixed bed reactor for biological artificial liver |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN210193854U (en) |
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2019
- 2019-06-14 CN CN201920900584.6U patent/CN210193854U/en active Active
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