CN112973535A - Magnetic driver with lifting type adjustable stirring angle for bioreactor - Google Patents
Magnetic driver with lifting type adjustable stirring angle for bioreactor Download PDFInfo
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- CN112973535A CN112973535A CN202110451324.7A CN202110451324A CN112973535A CN 112973535 A CN112973535 A CN 112973535A CN 202110451324 A CN202110451324 A CN 202110451324A CN 112973535 A CN112973535 A CN 112973535A
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- 238000003756 stirring Methods 0.000 title claims abstract description 58
- 238000007789 sealing Methods 0.000 claims abstract description 83
- 238000012546 transfer Methods 0.000 claims description 30
- 230000033001 locomotion Effects 0.000 claims description 7
- 238000000855 fermentation Methods 0.000 abstract description 15
- 230000004151 fermentation Effects 0.000 abstract description 15
- 238000004519 manufacturing process Methods 0.000 abstract description 15
- 229910001220 stainless steel Inorganic materials 0.000 abstract description 15
- 239000010935 stainless steel Substances 0.000 abstract description 15
- 230000005540 biological transmission Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000013019 agitation Methods 0.000 description 2
- 238000009434 installation Methods 0.000 description 2
- 238000003760 magnetic stirring Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000001360 synchronised effect Effects 0.000 description 2
- 238000011144 upstream manufacturing Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000005347 demagnetization Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000005389 magnetism Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000012429 reaction media Substances 0.000 description 1
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/02—Apparatus for enzymology or microbiology with agitation means; with heat exchange means
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Abstract
The invention relates to a lifting type magnetic driver with adjustable stirring angle for a bioreactor, belonging to the technical field of bioreactors. The device comprises a left sealing plate, a right sealing plate, a magnetic driver fixing device, a magnetic driver, a driving mechanism for lifting and adjusting the stirring angle and a driving mechanism guiding and fixing device; a magnetic driver fixing device is arranged between the left sealing plate and the right sealing plate; the magnetic driver fixing device is internally provided with a magnetic driver; and a driving mechanism guiding and fixing device are arranged between the left sealing plate and the right sealing plate, and the driving mechanism is connected with the magnetic driver fixing device. According to the invention, through the magnetic driver which is lifted and can adjust the stirring angle, the stirring driving of stainless steel tanks or biological fermentation bags with different angles and sizes is realized, the stirring driving of different tanks and fermentation bags by a single product is met, the use is flexible and changeable, the production cost and the production period are reduced, and the production efficiency is improved.
Description
Technical Field
The invention relates to a lifting type magnetic driver with adjustable stirring angle for a bioreactor, belonging to the technical field of bioreactors.
Background
The bioreactor engineering is a comprehensive application science which is started to rise in the early seventies of the last century, and the microorganisms are souls of the bioreactor engineering. Bioreactor engineering in modern sense is a technical and application-type open discipline formed by crossing and fusing multiple disciplines.
In a broad sense, bioreactor engineering consists of three parts: upstream engineering, midstream engineering and downstream engineering. Wherein the upstream engineering comprises breeding of excellent strains, determination of optimal reaction conditions (pH, temperature, dissolved oxygen and nutrient composition), preparation of nutrients and the like. The midstream engineering mainly refers to a process technology for culturing a large number of cells and producing metabolites in a reaction tank under the optimal reaction conditions. As can be seen from the above two, the equipment for bioreaction in bioreactor engineering has exhibited a lot of rigor in earlier designs.
Most of the existing biological reaction single equipment is in the form of a stainless steel tank type or a biological reaction bag, and the like, so that the price is high, and the manufacturing period is long. In these stand-alone installations, various types of stirring devices are generally provided, which are fastened directly to the stainless steel tank or to the housing of the bioreactor bag. As for the stainless steel tank type fermentation single-machine equipment, the installation angle of a stirring device arranged on the single machine is fixed, the specific position of stirring is also constant, the position and the stirring strength of the stirring device cannot be flexibly adjusted according to different reaction media and processes, and the pharmaceutical enterprises are required to configure different types of fermentation single-machine equipment matched with the stirring device according to different stirring media and process requirements. This greatly increases the production cost. On the other hand, in the case of a single-machine apparatus in the form of a bioreactor bag, the external shape of the bag is changed due to the difference of reaction batches and volumes, which directly affects that the stirring apparatus cannot flexibly and reasonably stir the reaction solution under different conditions, and the stirring distance is too far, so that the reaction solution in the bag cannot be stirred, or the stirring phenomenon occurs due to too close distance. For bioreactor systems, magnetic stirring devices are commonly used. This form of agitation, where the magnetic force generator is within a certain distance from the agitation actuator, may not be sufficient for use with the reactor equipment if the distance is too great or too small. Therefore, there is a need in the art for a magnetic driver that can adjust the distance between the magnetic force generator and the stirring actuator and the stirring angle.
Disclosure of Invention
The invention aims to solve the defects in the prior art and solve the technical problem of obtaining a magnetic driver capable of adjusting the distance between a magnetic force generator and a stirring actuator and the stirring angle.
In order to solve the above problems, the present invention provides a lifting type magnetic driver with adjustable stirring angle for a bioreactor, which comprises a left sealing plate, a right sealing plate, a magnetic driver fixing device, a magnetic driver, a driving mechanism for lifting the adjustable stirring angle, and a driving mechanism guiding and fixing device; a magnetic driver fixing device is arranged between the left sealing plate and the right sealing plate; the magnetic driver fixing device is internally provided with a magnetic driver; and a driving mechanism guiding and fixing device are arranged between the left sealing plate and the right sealing plate, and the driving mechanism is connected with the magnetic driver fixing device.
Preferably, the drive mechanism guides the attachment means in connection with the magnetic drive attachment means.
Preferably, the magnetic driver fixing device comprises a left fixing plate, a right fixing plate and a magnetic driver cover; a left fixing plate is arranged between the magnetic driver and the left closing plate; a right fixing plate is arranged between the magnetic driver and the right sealing plate; a magnetic driver cover surrounding the magnetic driver is arranged between the left fixing plate and the right fixing plate.
Preferably, the driving mechanism comprises a handle, a driving transfer device, a driving connecting rod device, a driving connecting bolt and a driving bottom plate; a driving bottom plate is arranged below the left fixing plate and the right fixing plate and is connected with one end of the driving connecting rod device through a driving connecting bolt; the other end of the driving connecting rod device is movably connected with the handle; the tail end of the handle, which is far away from the operator, is movably connected with the middle part of the driving transfer device; two ends of the driving transfer device are respectively and fixedly connected with the left sealing plate and the right sealing plate; the fixed connection part of the driving transfer device and the left sealing plate and the right sealing plate is arranged above the driving bottom plate.
Preferably, the other end of the driving connecting rod device is hinged with the handle, and the hinged position is arranged on the handle body close to the connecting position of the handle and the driving transfer device.
Preferably, the driving mechanism guiding and fixing device comprises a bearing track groove, a deep groove ball bearing and a fixing bolt which are respectively arranged on the left sealing plate and the right sealing plate and used for adjusting the angle and the up-down position of the magnetic driver; and the left fixing plate and the right fixing plate are respectively provided with a fixing bolt, the fixing bolts are sleeved with deep groove ball bearings, and the deep groove ball bearings are arranged in the grooves of the bearing tracks.
Preferably, the driving mechanism guiding and fixing device further comprises a guiding and fixing main plate, a fixing buckle and a guiding and fixing auxiliary plate; a guiding and fixing main plate and a guiding and fixing auxiliary plate are arranged vertically to the left sealing plate and the right sealing plate; the guiding and fixing main plate and the guiding and fixing auxiliary plate are provided with elongated slots for the movement of the handle; the outer side of the guide and fixed auxiliary plate is also provided with a fixed buckle for fixing the position of the handle.
Compared with the prior art, the invention has the following beneficial effects:
the stirring driving device realizes stirring driving of stainless steel tanks or biological fermentation bags with different angles and sizes, meets the requirement that a single product can be used for stirring driving of different tanks and fermentation bags, is flexible and changeable to use, greatly reduces the production cost and the production period, and improves the production efficiency.
The invention provides a magnetic driver with adjustable driving direction and driving height, a single product can drive magnetic stirring under different working conditions, the driving height and angle can be directly adjusted on line, and demagnetization and magnetism supply of stirring can be realized, so that the utilization rate is greatly improved, the cost of adding other stirring devices is saved, and the production cost is reduced.
Drawings
FIG. 1 is a schematic view of a whole lifting type stirring angle-adjustable magnetic driver for a bioreactor according to the present invention;
FIG. 2 is a first structural schematic view of a lifting type stirring angle adjustable magnetic driver for a bioreactor according to the present invention;
FIG. 3 is a schematic structural diagram of a second lifting type stirring angle adjustable magnetic driver for a bioreactor according to the present invention;
FIG. 4 is a partial sectional view showing the structure of the middle fixing device of the magnetic force driver with adjustable stirring angle in a lifting type for a bioreactor according to the present invention;
FIG. 5 is a view of a handle driving device of a lifting type stirring angle adjustable magnetic driver for a bioreactor according to the present invention;
FIG. 6 is a transmission diagram of the left sealing plate and the deep groove ball bearing of the lifting type magnetic driver with adjustable stirring angle for the bioreactor provided by the invention;
FIG. 7 is a transmission diagram of the right sealing plate and the deep groove ball bearing of the magnetic force driver with lifting and stirring angle adjustable for the bioreactor provided by the invention.
Reference numerals: 1. a left sealing plate; 2. a magnetic drive fixing device; 2-1, a left fixing plate; 2-2. a right fixing plate; 2-3. a magnetic driver cover; 2-4, deep groove ball bearing; 2-5, fixing the bolt; 3. a magnetic drive; 4. a right seal plate; 5. a top plate; 6. a drive mechanism; 6-1, a handle; 6-2, driving the transfer device; 6-3, driving the connecting rod device; 6-4, driving the connecting bolt; 6-5, driving the bottom plate; 7. the driving mechanism guides the fixing device; 7-1, guiding and fixing the main board; 7-2, fixing a buckle; 7-3, guiding and fixing the auxiliary plate.
Detailed Description
In order to make the invention more comprehensible, preferred embodiments are described in detail below with reference to the accompanying drawings:
as shown in fig. 1-7, the present invention provides a lifting type magnetic driver with adjustable stirring angle for a bioreactor, which comprises a left sealing plate 1, a right sealing plate 4, a magnetic driver fixing device 2, a magnetic driver 3, a driving mechanism 6 with adjustable stirring angle and a driving mechanism guiding and fixing device 7; a magnetic driver fixing device 2 is arranged between the left sealing plate 1 and the right sealing plate 4; the magnetic driver fixing device 2 is internally provided with a magnetic driver 3; a driving mechanism 6 and a driving mechanism guiding and fixing device 7 are arranged between the left sealing plate 1 and the right sealing plate 4, and the driving mechanism 6 is connected with the magnetic driver fixing device 2. The drive mechanism guides the attachment means 7 into connection with the magnetic drive attachment means 2. The magnetic driver fixing device 2 comprises a left fixing plate 2-1, a right fixing plate 2-2 and a magnetic driver cover 2-3; a left fixing plate 2-1 is arranged between the magnetic driver 3 and the left sealing plate 1; a right fixing plate 2-2 is arranged between the magnetic driver 3 and the right sealing plate 4; a magnetic driver cover 2-3 surrounding the magnetic driver 3 is arranged between the left fixing plate 2-1 and the right fixing plate 2-2. The driving mechanism 6 comprises a handle 6-1, a driving transfer device 6-2, a driving connecting rod device 6-3, a driving connecting bolt 6-4 and a driving bottom plate 6-5; a driving bottom plate 6-5 is arranged below the left fixing plate 2-1 and the right fixing plate 2-2, and the driving bottom plate 6-5 is connected with one end of a driving connecting rod device 6-3 through a driving connecting bolt 6-4; the other end of the driving connecting rod device 6-3 is movably connected with the handle 6-1; the tail end of the handle 6-1, which is far away from the operator, is movably connected with the middle part of the driving transfer device 6-2; two ends of the driving transfer device 6-2 are respectively and fixedly connected with the left sealing plate 1 and the right sealing plate 4; the fixed connection part of the driving transfer device 6-2 and the left sealing plate 1 and the right sealing plate 4 is arranged above the driving bottom plate 6-5. The other end of the driving connecting rod device 6-3 is hinged with the handle 6-1, and the hinged part is arranged on the handle 6-1 body close to the connecting part of the handle 6-1 and the driving transfer device 6-2. The driving mechanism guiding and fixing device 7 comprises a left sealing plate 1 and a right sealing plate 4 which are respectively provided with a bearing track groove, a deep groove ball bearing 2-4 and a fixing bolt 2-5 for adjusting the angle and the up-down position of the magnetic driver 3; the left fixing plate 2-1 and the right fixing plate 2-2 are respectively provided with a fixing bolt 2-5, the fixing bolt 2-5 is sleeved with a deep groove ball bearing 2-4, and the deep groove ball bearing 2-4 is arranged in a groove of a bearing track. The driving mechanism guiding and fixing device 7 further comprises a guiding and fixing main board 7-1, a fixing buckle 7-2 and a guiding and fixing auxiliary board 7-3; a guiding and fixing main plate 7-1 and a guiding and fixing auxiliary plate 7-3 are arranged vertically to the left sealing plate 1 and the right sealing plate 4; long grooves for the movement of the handle are arranged on the main guiding and fixing plate 7-1 and the auxiliary guiding and fixing plate 7-3; the outer side of the guide and fixing auxiliary plate 7-3 is also provided with a fixing buckle 7-2 for fixing the position of the handle 6-1.
The invention provides a lifting type magnetic driver with adjustable stirring angle for a bioreactor. The stirring direction and the height of the magnetic stirrer are not adjustable, the pertinence of the stirrer is single, the adjusting difficulty of the stirring of the feed liquid is high, the production cost is high, the processing period is long, and the like. The magnetic driver comprises a left sealing plate 1 and a right sealing plate 4, a magnetic driver fixing device 2 is arranged between the left sealing plate 1 and the right sealing plate 4, a magnetic driver 3 is arranged on the inner side of the fixing device 2, a handle driving mechanism 6 is arranged on the inner side of the fixing device 2, and a top plate 5 is arranged at the upper end of the handle driving mechanism 6.
The fixing device 2 mainly comprises a left fixing plate 2-1, a right fixing plate 2-2, a magnetic driver cover 2-3, a deep groove ball bearing 2-4, a fixing bolt 2-5 and the like. The left fixing plate 2-1 is fixed with the magnetic driver 3 through bolts, and the right fixing plate 2-2 is fixed with the magnetic driver 3 through bolts; the left fixing plate 2-1 and the right fixing plate 2-2 are respectively fixed with a magnetic drive cover 2-3 through bolts, synchronous movement of the left fixing plate 2-1, the right fixing plate 2-2, the magnetic drive cover 2-3 and the magnetic drive cover 3 can be achieved through the bolts, through holes and threaded holes are formed in the left fixing plate 2-1, the right fixing plate 2-2 and the magnetic drive cover 2-3, one end of a fixing bolt 2-5 penetrates through the through hole in the magnetic drive cover 2-3 and is fixed on the left fixing plate 2-1 and the right fixing plate 2-2 through threaded connection, a deep groove ball bearing 2-4 is sleeved at the other end of the fixing bolt 2-5, and the deep groove ball bearing 2-4 can roll and rotate around the central shaft of the fixing bolt 2-5.
The handle driving mechanism 6 mainly comprises a handle 6-1, a driving transfer device 6-2, a driving connecting rod device 6-3, a driving connecting bolt 6-4, a driving bottom plate 6-5 and the like. The handle 6-1 is hinged with the driving connecting rod device 6-3, the lower end of the handle 6-1 is hinged with the driving transfer device 6-2, the lower end of the driving connecting rod device 6-3 is hinged with the driving connecting bolt 6-4, the driving connecting bolt 6-4 is fixed with the driving bottom plate 6-5 through a bolt, after the driving transfer device 6-2 is fixed, the handle 6-1 is held by a hand, when the handle 6-1 rotates around the driving transfer device 6-2, the handle 6-1, the driving connecting rod device 6-3 and the driving connecting bolt 6-4 drive the driving bottom plate 6-5 to move up and down in a hinged mode, and the left end and the right end of the driving transfer device 6-2 are fixedly connected with the left sealing plate 1 and the right sealing plate 4 through bolts respectively.
The guiding and fixing device 7 mainly comprises a guiding and fixing main board 7-1, a fixing buckle 7-2, a guiding and fixing auxiliary board 7-3 and the like. The guide and fixing auxiliary plate 7-3 is provided with a groove, the front end of the guide and fixing auxiliary plate 7-3 is fixed on the guide and fixing main plate 7-1 through a bolt, the left side and the right side of the guide and fixing auxiliary plate 7-3 are respectively fixed on the left sealing plate 1 and the right sealing plate 4 through bolts, the guide and fixing main plate 7-1 is provided with a groove, a handle 6-1 can rotate up and down around a driving transfer device 6-2 in the groove on the guide and fixing main plate 7-1 and the guide and fixing auxiliary plate 7-3, a fixing buckle 7-2 is arranged between the top plate 5 and the guide and fixing auxiliary plate 7-3, the fixing buckle 7-2 is hinged with the top plate 5, the fixing buckle 7-2 can rotate in a groove on the surface of the top plate 5, when the handle 6-1 moves to the uppermost end, the handle 6-1 can be limited by manually shifting the fixing buckle 7-2, and the guiding and fixing device 7 is fixed on the stainless steel tank body or the biological fermentation bag.
Bearing track grooves are formed in the inner sides of the left sealing plate 1 and the right sealing plate 4, the bearing track grooves in the left sealing plate 1 and the right sealing plate 4 are bilaterally symmetrical, corresponding included angles are reserved on two sides of each track groove, when the left sealing plate 1 and the right sealing plate 4 are fixedly matched with the driving transfer device 6-2 and the guiding and fixing device 7, the deep groove ball bearings 2-4 are just positioned in the track grooves in the side edges of the left sealing plate 1 and the right sealing plate 4, the deep groove ball bearings 2-4 are in clearance fit with the left sealing plate 1 and the right sealing plate 4, the deep groove ball bearings 2-4 can slide in the track grooves in the side surfaces of the left sealing plate 1 and the right sealing plate 4, when the handle 6-1 is positioned at the highest end, the handle 6-1 is locked by the fixing buckle 7-2, the position of the handle 6-1 is limited by the fixing buckle 7-2, when, at the moment, the handle 6-1 is held by a hand only by pulling the position of the fixing buckle 7-2 manually, the handle 6-1 is pressed downwards along the direction of the rotating shaft of the handle, the handle 6-1 directly moves the driving bottom plate 6-5 downwards through transmission, the driving bottom plate 6-5 drives the deep groove ball bearing 2-4 on the middle fixing device 2 to move along the track grooves in the left closing plate 1 and the right closing plate 4, the whole middle fixing device 2 and the magnetic driver 3 move according to the track of the deep groove ball bearing 2-4 moving in the track grooves of the left closing plate 1 and the right closing plate 4, when the deep groove ball bearing 2-4 continuously slides downwards, the magnetic driver 3 is lifted upwards, at the moment, the height of the magnetic driver 3 is raised, the distance between the magnetic driver 3 and the stainless steel tank body for biological fermentation or the magnetic stirrer in the biological fermentation bag is reduced, stirring device in the stainless steel jar body or the biological fermentation bag rotates through magnetic drive, accomplish the stirring to the feed liquid in the stainless steel jar body or the biological fermentation bag, when continuing to drive handle 6-1 downwards, deep groove ball bearing 2-4 is at the track recess internal motion in left shrouding 1 and the right shrouding 4 along, 3 axis of magnetic drive and the corresponding change of contained angle between the horizontal plane this moment, then the change of magnetic drive direction has been realized this moment, thereby realized the stirring drive to the stainless steel jar body of different angles and size or biological fermentation bag, satisfied single product can be to the stirring drive of different jar bodies and fermentation bag, it is nimble to use changeable, greatly reduced manufacturing cost and production cycle, and the production efficiency is improved.
Examples
As shown in fig. 1-3, the portable magnetic force sealing device comprises a left sealing plate 1, a magnetic force driver fixing device 2 is arranged on the right side of the left sealing plate 1, a magnetic force driver 3 is arranged on the inner side of the fixing device 2, a right sealing plate 4 is arranged on the right side of the fixing device 2, a handle driving mechanism 6 is arranged on the inner side of the fixing device 2, and a top plate 5 is arranged at the upper end of the handle driving mechanism 6.
The middle fixing device 2 may be as shown in fig. 1, 2 and 4, and mainly includes a left fixing plate 2-1, a right fixing plate 2-2, a magnetic driver cover 2-3, a deep groove ball bearing 2-4, a fixing bolt 2-5, and the like. The left fixing plate 2-1 is fixed with the magnetic driver 3 through a bolt, the right fixing plate 2-2 is fixed with the magnetic driver 3 through a bolt, the left side of the left fixing plate 2-1 and the right side of the right fixing plate 2-2 are fixed with the magnetic driver cover 2-3 through a bolt, synchronous movement of the left fixing plate 2-1, the right fixing plate 2-2, the magnetic driver cover 2-3 and the magnetic driver 3 can be realized through the bolt, through holes and threaded holes are formed in the left fixing plate 2-1, the right fixing plate 2-2 and the magnetic driver cover 2-3, as shown in figure 4, one end of a fixing bolt 2-5 penetrates through the through hole in the magnetic driver cover 2-3 and is fixed on the left fixing plate 2-1 and the right fixing plate 2-2 through a threaded connection, the other end of the fixing bolt 2-5 is sleeved with a deep groove ball bearing 2-, the deep groove ball bearing 2-4 can roll and rotate around the central shaft of the fixing bolt 2-5.
As an embodiment, the handle driving device 6 provided by the implementation of the invention can mainly comprise a handle 6-1, a driving transfer device 6-2, a driving connecting rod device 6-3, a driving connecting bolt 6-4, a driving bottom plate 6-5 and the like as shown in FIG. 5. The handle 6-1 is hinged with the driving connecting rod device 6-3, the lower end of the handle 6-1 is hinged with the driving transfer device 6-2, the lower end of the driving connecting rod device 6-3 is hinged with the driving connecting bolt 6-4, the driving connecting bolt 6-4 is fixed with the driving bottom plate 6-5 through a bolt, after the driving transfer device 6-2 is fixed, the handle 6-1 is held by a hand, when the handle 6-1 rotates around the driving transfer device 6-2, the handle 6-1, the driving connecting rod device 6-3 and the driving connecting bolt 6-4 drive the driving bottom plate 6-5 to move up and down in a hinged mode, and the left end and the right end of the driving transfer device 6-2 are respectively fixedly connected with the left sealing plate 1 and the right sealing plate 4 through bolts.
The driving mechanism guide fixing device 7 can be as shown in fig. 3, and mainly comprises a guide and fixing main plate 7-1, a fixing buckle 7-2, a guide and fixing auxiliary plate 7-3 and the like. The guide and fixing auxiliary plate 7-3 is provided with a U-shaped groove, the front end of the guide and fixing auxiliary plate 7-3 is fixed on the guide and fixing main plate 7-1 through bolts, the left side and the right side of the guide and fixing auxiliary plate 7-3 are respectively fixed on the left sealing plate 1 and the right sealing plate 4 through bolts, the guide and fixing main plate 7-1 is provided with a U-shaped groove, a handle 6-1 can rotate up and down around a driving transfer device 6-2 in the U-shaped groove on the guide and fixing main plate 7-1 and the guide and fixing auxiliary plate 7-3, a fixing buckle 7-2 is arranged between the top plate 5 and the guide and fixing auxiliary plate 7-3, the fixing buckle 7-2 is hinged with the top plate 5, the fixing buckle 7-2 can rotate in a groove on the surface of the top plate 5, when the handle 6-1 moves to the uppermost end, the handle 6-1 can be limited by manually shifting the fixing buckle 7-2, and the guide fixing device 7 is fixed on the stainless steel tank body or the biological fermentation bag.
The movement track of the invention is shown in fig. 6 and 7, the inner sides of the left closing plate 1 and the right closing plate 4 are both provided with track grooves, the track grooves on the left closing plate 1 and the right closing plate 4 are bilaterally symmetrical, a corresponding included angle is left at the two sides of each track groove, when the left closing plate 1 and the right closing plate 4 are mutually and fixedly matched with the driving transfer device 6-2 and the guiding and fixing device 7, the deep groove ball bearing 2-4 is just positioned in the track grooves at the side surfaces of the left closing plate 1 and the right closing plate 4, the deep groove ball bearing 2-4 is in clearance fit with the left closing plate 1 and the right closing plate 4, the deep groove ball bearing 2-4 can slide in the track grooves at the side surfaces of the left closing plate 1 and the right closing plate 4, when the handle 6-1 is positioned at the highest end, the fixing buckle 7-2 locks the handle 6-1, the fixing, when the position of the magnetic driver 3 needs to be adjusted, at this time, the position of the fixing buckle 7-2 only needs to be manually pulled out, the handle 6-1 is held by hand and is pressed downwards along the direction of the rotating shaft of the handle 6-1, at this time, the handle 6-1 directly drives the bottom plate 6-5 to move downwards through transmission, the bottom plate 6-5 is driven to drive the deep groove ball bearing 2-4 on the fixing device 2 to move along the track grooves in the left closing plate 1 and the right closing plate 4, the whole fixing device 2 and the magnetic driver 3 move according to the track of the deep groove ball bearing 2-4 moving in the track grooves of the left closing plate 1 and the right closing plate 4, when the deep groove ball bearing 2-4 continuously slides downwards, the magnetic driver 3 is lifted upwards, at this time, the height of the magnetic driver 3 is raised, the distance between the magnetic driver 3 and a stainless steel tank body for biological fermentation or a magnetic stirrer in a biological reaction bag is reduced, stirring device in the stainless steel jar body or the biological reaction bag rotates through magnetic drive, accomplish the stirring to the feed liquid in the stainless steel jar body or the biological reaction bag, when continuing to drive handle 6-1 downwards, deep groove ball bearing 2-4 moves in the track recess in left shrouding 1 and the right shrouding 4, 3 axis of magnetic drive and the corresponding change of contained angle between the horizontal plane this moment, then the change of 3 directions of magnetic drive has been realized this moment, thereby realized the stirring drive to the stainless steel jar body of different angles and size or biological reaction bag, satisfied single product can be to the stirring drive of different jar bodies and reaction bags, it is nimble changeable to use, greatly reduced manufacturing cost and production cycle, efficiency is improved.
While the invention has been described with respect to a preferred embodiment, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention. Those skilled in the art can make various changes, modifications and equivalent arrangements, which are equivalent to the embodiments of the present invention, without departing from the spirit and scope of the present invention, and which may be made by utilizing the techniques disclosed above; meanwhile, any changes, modifications and variations of the above-described embodiments, which are equivalent to those of the technical spirit of the present invention, are within the scope of the technical solution of the present invention.
Claims (7)
1. The utility model provides a bioreactor is with adjustable stirring angle's of over-and-under type magnetic driver which characterized in that: the device comprises a left sealing plate, a right sealing plate, a magnetic driver fixing device, a magnetic driver, a driving mechanism for lifting and adjusting the stirring angle and a driving mechanism guiding and fixing device; a magnetic driver fixing device is arranged between the left sealing plate and the right sealing plate; the magnetic driver fixing device is internally provided with a magnetic driver; and a driving mechanism guiding and fixing device are arranged between the left sealing plate and the right sealing plate, and the driving mechanism is connected with the magnetic driver fixing device.
2. The magnetic force driver with adjustable lifting and stirring angles for bioreactors according to claim 1, wherein: the driving mechanism guides the fixing device to be connected with the magnetic driver fixing device.
3. The magnetic force driver with adjustable lifting and stirring angles for bioreactors according to claim 2, wherein: the magnetic driver fixing device comprises a left fixing plate, a right fixing plate and a magnetic driver cover; a left fixing plate is arranged between the magnetic driver and the left closing plate; a right fixing plate is arranged between the magnetic driver and the right sealing plate; a magnetic driver cover surrounding the magnetic driver is arranged between the left fixing plate and the right fixing plate.
4. The magnetic force driver with adjustable lifting and stirring angles for bioreactors according to claim 3, wherein: the driving mechanism comprises a handle, a driving transfer device, a driving connecting rod device, a driving connecting bolt and a driving bottom plate; a driving bottom plate is arranged below the left fixing plate and the right fixing plate and is connected with one end of the driving connecting rod device through a driving connecting bolt; the other end of the driving connecting rod device is movably connected with the handle; the tail end of the handle, which is far away from the operator, is movably connected with the middle part of the driving transfer device; two ends of the driving transfer device are respectively and fixedly connected with the left sealing plate and the right sealing plate; the fixed connection part of the driving transfer device and the left sealing plate and the right sealing plate is arranged above the driving bottom plate.
5. The magnetic force driver with adjustable lifting and stirring angles for bioreactors according to claim 4, wherein: the other end of the driving connecting rod device is hinged with the handle, and the hinged position is arranged on the handle body close to the connecting position of the handle and the driving transfer device.
6. The magnetic force driver with adjustable lifting and stirring angles for bioreactors according to claim 5, wherein: the driving mechanism guiding and fixing device comprises a left sealing plate and a right sealing plate which are respectively provided with a bearing track groove, a deep groove ball bearing and a fixing bolt, wherein the bearing track groove, the deep groove ball bearing and the fixing bolt are used for adjusting the angle and the up-down position of the magnetic driver; and the left fixing plate and the right fixing plate are respectively provided with a fixing bolt, the fixing bolts are sleeved with deep groove ball bearings, and the deep groove ball bearings are arranged in the grooves of the bearing tracks.
7. The magnetic force driver with adjustable lifting and stirring angles for bioreactors according to claim 6, wherein: the driving mechanism guiding and fixing device also comprises a guiding and fixing main board, a fixing buckle and a guiding and fixing auxiliary board; a guiding and fixing main plate and a guiding and fixing auxiliary plate are arranged vertically to the left sealing plate and the right sealing plate; the guiding and fixing main plate and the guiding and fixing auxiliary plate are provided with elongated slots for the movement of the handle; the outer side of the guide and fixed auxiliary plate is also provided with a fixed buckle for fixing the position of the handle.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110451324.7A CN112973535A (en) | 2021-04-26 | 2021-04-26 | Magnetic driver with lifting type adjustable stirring angle for bioreactor |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110451324.7A CN112973535A (en) | 2021-04-26 | 2021-04-26 | Magnetic driver with lifting type adjustable stirring angle for bioreactor |
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| CN112973535A true CN112973535A (en) | 2021-06-18 |
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| CN202110451324.7A Pending CN112973535A (en) | 2021-04-26 | 2021-04-26 | Magnetic driver with lifting type adjustable stirring angle for bioreactor |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113842826A (en) * | 2021-10-13 | 2021-12-28 | 东富龙科技集团股份有限公司 | Disposable joins in marriage liquid magnetic drive device that system can break away with over-and-under type |
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