CN209530225U - A kind of room temperature isolates and purifies the casing filtering device of excretion body - Google Patents
A kind of room temperature isolates and purifies the casing filtering device of excretion body Download PDFInfo
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- CN209530225U CN209530225U CN201920062705.4U CN201920062705U CN209530225U CN 209530225 U CN209530225 U CN 209530225U CN 201920062705 U CN201920062705 U CN 201920062705U CN 209530225 U CN209530225 U CN 209530225U
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- excretion body
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Abstract
The utility model relates to a kind of filtering device technical fields of excretion body, especially a kind of room temperature isolates and purifies the casing filtering device of excretion body, including outer tube, both ends are fixed with card slot at the top of outer tube, fixture block is fixed in card slot, filtering device ontology is fixed between two fixture blocks, filtering device bodies top is fixed with liquid inlet, filtering device bodies top is fixed with micromotor, the output end of micromotor is fixedly connected with shaft, shaft passes through filtering device ontology and is fixedly connected with fixed link, stirring blade is fixed in fixed link, fixed link is fixed with fixed plate, several through-holes are fixed in fixed plate, fixed plate bottom is fixed with brush body, it it is fixed with the first strainer filtering in filtered device noumenon crosses in device noumenon and be fixed with the second strainer, filtered device noumenon bottom fixation is set There is a liquid outlet, the utility model does not have impurity protein in extracted excretion body.
Description
Technical field
The utility model relates to a kind of filtering device technical fields of excretion body more particularly to a kind of room temperature to isolate and purify outside
Secrete the casing filtering device of body.
Background technique
Excretion body refers to a kind of diameter 30-1000nm, interior to have rouge containing Multiple components such as protein, lipid and nucleic acid
The film source property vesicles of matter double-layer structure.The form that excretion body can cross cell exocytosis is discharged into extracellular environment, is present in each
In kind body fluid and culture cell conditioned medium.Biological active agents can be selectively delivered to target cell by excretion body, different thin
Intercellular carries out information transmitting, adjusts intercellular signal transduction, and it is for example thin to participate in human body many important physiology or pathologic process
Intracellular growth, differentiation, proliferation, vascularization, apoptosis, tumor-infiltrated and transfer etc., play a variety of important biological functions.It compares
In tissue biopsy, " the liquid biopsy " of excretion body have it is traumatic it is small, easy to operate, that sampling is convenient and sample source is abundant etc. is multiple
Advantage.The quality of excretion body is affected by many factors.Different extracting method influence excretion bodies and its content contains
Amount, activity.Ultrafiltration centrifugal process is that Selective Separation is carried out using the ultrafiltration membrane of different retentions relative molecular mass (MWCO), small point
Sub- substance will be filtered the other side of film, and the high relative molecular mass substance for being greater than membrane aperture is then trapped on ultrafiltration membrane,
This method is fairly simple efficiently, but the disadvantage is that excretion body may block filter hole, impurity protein in extracted excretion body
More and excretion body is lost serious.
Utility model content
Purpose of the utility model is to solve disadvantages existing in the prior art, and a kind of room temperature separation proposed is pure
The outside the pale of civilization casing filtering device for secreting body.
To achieve the goals above, the utility model adopts the technical scheme that
The casing filtering device that a kind of room temperature isolates and purifies excretion body, including outer tube are designed, both ends are equal at the top of the outer tube
It is fixed with card slot, fixture block is fixed in the card slot, filtering device ontology, institute are fixed between two fixture blocks
It states filtering device bodies top and is fixed with liquid inlet, the filtering device bodies top is fixed with micromotor, described
The input terminal of micromotor is connected with external power supply, and the output end of the micromotor is fixedly connected with shaft, and the shaft is worn
Filtered device noumenon is fixedly connected with fixed link, several stirring blades, the fixed link are fixed in the fixed link
One end far from shaft is fixed with fixed plate, several through-holes are fixed in the fixed plate, and the fixed plate bottom is solid
Surely it is equipped with brush body, is fixed in filtered device noumenon described in the first strainer and is fixed in the filtered device noumenon
Second strainer, the filtered device noumenon bottom are fixed with liquid outlet.
Preferably, the fixture block matches with card slot.
Preferably, first strainer is between brush body and the second strainer.
Preferably, second strainer is between the first strainer and liquid outlet.
The utility model proposes a kind of room temperature isolate and purify the casing filtering device of excretion body, beneficial effect is: will
Liquid pours into filtering device ontology from liquid inlet, and rotates the fixed link in minitype motor driving shaft, makes paddle
Piece increases flowing to liquid agitation, while the brush body in the fixed plate of bottom of fixed will gently swipe the first strainer, prevent
Some impurity block the first strainer, and through-hole is equipped in fixed plate, this is in order to allow the liquid to flow into fixed plate bottom, when the
After one strainer carries out filtering just slightly, excretion body will not be made to lose serious, then once filtered by the second strainer, it is at this moment miscellaneous
Matter is reduced, will not be by filter net jam, and can filter cleaner, and filtered excretion body will flow into outer tube.
Detailed description of the invention
Fig. 1 be the utility model proposes a kind of room temperature isolate and purify excretion body casing filtering device structural representation
Figure；
Fig. 2 be the utility model proposes Fig. 1 A at enlarged structure schematic diagram.
In figure: outer tube 1, micromotor 2, shaft 3, fixed link 4, stirring blade 5, fixed plate 6, through-hole 7, brush body 8,
One strainer 9, the second strainer 10, liquid inlet 11, liquid outlet 12, filtering device ontology 13, fixture block 14, card slot 15.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
Clearly and completely describe, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than whole
Embodiment.
Referring to Fig.1-2, a kind of room temperature isolates and purifies the casing filtering device of excretion body, including outer tube 1, and the outer tube 1 pushes up
Portion both ends are fixed with card slot 15, and fixture block 14 is fixed in the card slot 15, and the fixture block 14 matches with card slot 15,
It is fixed with filtering device ontology 13 between two fixture blocks 14, is fixed with liquid at the top of the filtering device ontology 13 and enters
Mouthfuls 11, micromotor 2, the input terminal and external power supply of the micromotor 2 are fixed at the top of the filtering device ontology 13
It is connected, the output end of the micromotor 2 is fixedly connected with shaft 3, and the shaft 3 passes through filtering device ontology 13 and is fixedly connected
There is fixed link 4, several stirring blades 5 are fixed in the fixed link 4, liquid is poured into filtering device from liquid inlet 11
In ontology 13, and make micromotor 2 that the fixed link 4 in shaft 3 be driven to rotate, makes stirring blade 5 to liquid agitation, increase stream
It is dynamic.
The fixed link 4 is fixed with fixed plate 6 far from one end of shaft 3, is fixed with several in the fixed plate 6
Through-hole 7,6 bottom of fixed plate is fixed with brush body 8, while the brush body 8 in the fixed plate 6 of bottom of fixed will gently
The first strainer 9 is swiped, prevents some impurity from blocking the first strainer 9, through-hole 7 is equipped in fixed plate 6, this is to enable liquid
Enough flow into 6 bottom of fixed plate.
It is fixed in filtered device noumenon 13 described in the first strainer 9 and is fixed in the filtered device noumenon 13
Second strainer 10, first strainer 9 are located between brush body 8 and the second strainer 10, filtered 13 bottom of device noumenon
Be fixed with liquid outlet 12, second strainer 10 between the first strainer 9 and liquid outlet 12, when the first strainer 9 into
After the filtering of row just slightly, excretion body will not be made to lose serious, then once filtered by the second strainer 10, at this moment impurity subtracts
It is few, will not be by filter net jam, and can filter cleaner, filtered excretion body will flow into outer tube 1.
The preferable specific embodiment of the above, only the utility model, but the protection scope of the utility model is not
It is confined to this, anyone skilled in the art is within the technical scope disclosed by the utility model, practical according to this
Novel technical solution and its utility model design are subject to equivalent substitution or change, should all cover the protection model in the utility model
Within enclosing.
Claims (4)
1. a kind of room temperature isolates and purifies the casing filtering device of excretion body, including outer tube (1), which is characterized in that the outer tube (1)
Top both ends are fixed with card slot (15), are fixed with fixture block (14) in the card slot (15), two fixture blocks (14)
Between be fixed with filtering device ontology (13), be fixed with liquid inlet (11), institute at the top of the filtering device ontology (13)
It states and is fixed with micromotor (2) at the top of filtering device ontology (13), the input terminal and external power supply phase of the micromotor (2)
Even, the output end of the micromotor (2) is fixedly connected with shaft (3), and the shaft (3) is solid across filtering device ontology (13)
Surely it is connected with fixed link (4), several stirring blades (5) is fixed on the fixed link (4), the fixed link (4) is separate
One end of shaft (3) is fixed with fixed plate (6), several through-holes (7), the fixation are fixed on the fixed plate (6)
Plate (6) bottom is fixed with brush body (8), is fixed with the first strainer (9) described mistake in the filtered device noumenon (13)
It is fixed with the second strainer (10) in filtering device ontology (13), filtered device noumenon (13) bottom is fixed with liquid
It exports (12).
2. the casing filtering device that a kind of room temperature according to claim 1 isolates and purifies excretion body, which is characterized in that described
Fixture block (14) matches with card slot (15).
3. the casing filtering device that a kind of room temperature according to claim 1 isolates and purifies excretion body, which is characterized in that described
First strainer (9) is located between brush body (8) and the second strainer (10).
4. the casing filtering device that a kind of room temperature according to claim 1 isolates and purifies excretion body, which is characterized in that described
Second strainer (10) is between the first strainer (9) and liquid outlet (12).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920062705.4U CN209530225U (en) | 2019-01-15 | 2019-01-15 | A kind of room temperature isolates and purifies the casing filtering device of excretion body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201920062705.4U CN209530225U (en) | 2019-01-15 | 2019-01-15 | A kind of room temperature isolates and purifies the casing filtering device of excretion body |
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| Publication Number | Publication Date |
|---|---|
| CN209530225U true CN209530225U (en) | 2019-10-25 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920062705.4U Active CN209530225U (en) | 2019-01-15 | 2019-01-15 | A kind of room temperature isolates and purifies the casing filtering device of excretion body |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111575165A (en) * | 2020-05-29 | 2020-08-25 | 南方医科大学珠江医院 | Sleeve filtering device for separating and purifying exosome at normal temperature |
-
2019
- 2019-01-15 CN CN201920062705.4U patent/CN209530225U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111575165A (en) * | 2020-05-29 | 2020-08-25 | 南方医科大学珠江医院 | Sleeve filtering device for separating and purifying exosome at normal temperature |
| CN111575165B (en) * | 2020-05-29 | 2023-10-03 | 南方医科大学珠江医院 | Sleeve filtering device for separating and purifying exosomes at normal temperature |
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