CN207832752U - A kind of connection structure of preparative scale chromatography column - Google Patents
A kind of connection structure of preparative scale chromatography column Download PDFInfo
- Publication number
- CN207832752U CN207832752U CN201721929539.0U CN201721929539U CN207832752U CN 207832752 U CN207832752 U CN 207832752U CN 201721929539 U CN201721929539 U CN 201721929539U CN 207832752 U CN207832752 U CN 207832752U
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- China
- Prior art keywords
- filter membrane
- filter
- chromatography column
- preparative scale
- connection structure
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Abstract
The utility model discloses a kind of connection structures of preparative scale chromatography column, including be sequentially communicated end cap, connector, filter, take over and conduit；The end cap is tightly connected with connector by the first sealing ring；The lower end of taking over is equipped with the first groove, and the size of the filter and the first groove matches, and described take over is tightly connected with connector by the second sealing ring；Described take over is tightly connected with conduit；The filter includes the second filter membrane positioned at the first filter membrane of upper surface and positioned at lower surface, and the aperture of first filter membrane is 0.45 μm, the aperture of second filter membrane is 0.22 μm.The connection structure of the preparative scale chromatography column improves the mask work efficiency of preparative scale chromatography instrument, have preferably isolate and purify effect and compared with mass-flux.
Description
Technical field
The utility model is related to chromatographic apparatus accessory technical field more particularly to a kind of connection knots of preparative scale chromatography column
Structure.
Background technology
High performance liquid chromatography (High Performance Liquid Chromatography/HPLC) is also known as " high pressure
Liquid chromatogram ", " high-speed liquid chromatography ", " high separation liquid chromatogram ", " modern age column chromatography " etc..High performance liquid chromatography is chromatography
One important branch of method, using liquid as mobile phase, using high pressure transfusion system, by the single solvent or not with opposed polarity
The mobile phases such as mixed solvent, buffer solution in proportion are pumped into the chromatographic column equipped with stationary phase, after each ingredient is detached in column, into
Enter detector to be detected or further collect, to realize analysis or separation to sample.This method has become chemistry, doctor
Important separate analytical technique application in the ambits such as, industry, agronomy, commodity inspection and method inspection.
Analytic type chromatography requires separating degree height, high sensitivity, for the purpose of assay.And preparative liquid chromatography more side
It is big to overweight the circulation that purity after requiring separation is high, allows.
Utility model content
For overcome the deficiencies in the prior art, the purpose of this utility model is to provide a kind of connections of preparative scale chromatography column
Structure.
The purpose of this utility model adopts the following technical scheme that realization：
A kind of connection structure of preparative scale chromatography column, including be sequentially communicated end cap, connector, filter, take over and conduit；
The end cap is tightly connected with connector by the first sealing ring；The lower end of taking over is equipped with the first groove, the filter and the
The size of one groove matches, and described take over is tightly connected with connector by the second sealing ring；It is described to take over and the airtight company of conduit
It connects；The filter includes the second filter membrane positioned at the first filter membrane of upper surface and positioned at lower surface, the hole of first filter membrane
Diameter is 0.45 μm, the aperture of second filter membrane is 0.22 μm.
Further, the connector includes first end and the second end, and the first end connects with the end cap screw thread
It connects, the second end is threadedly coupled with described take over.
Further, the end cap is equipped with the second groove, the outer diameter of first sealing ring and second groove
Internal diameter matches.
Further, the outer diameter of the internal diameter and the first end of first sealing ring matches.
Further, the filter includes being used to support the bracing ring of first filter membrane or the second filter membrane and for solid
Determine the casing of bracing ring.
Further, the bracing ring is TPU.
Further, described sleeve pipe is spring-backed quill.
Compared with prior art, the beneficial effects of the utility model are：
The connection structure of preparative scale chromatography column provided by the utility model shortens work without being individually filtered operation
Sequence improves mask work efficiency.Preferable balance is achieved between the high efficiency and flow of separation, can be allowed larger
Circulation.
Description of the drawings
Fig. 1 is the vertical section structure schematic diagram of the utility model；
Fig. 2 is the structural schematic diagram of the filter of the utility model.
In figure, each reference numeral：1, end cap；11, the second groove；2, connector；21, first end；22, the second end；3、
Filter；31, the first filter membrane；32, the second filter membrane；33, bracing ring；34, casing；4, it takes over；41, the first groove；5, conduit；6、
First sealing ring；7, the second sealing ring.
Specific implementation mode
In the following, in conjunction with attached drawing and specific implementation mode, the utility model is described further, it should be noted that
Under the premise of not colliding, it can be formed in any combination between various embodiments described below or between each technical characteristic new
Embodiment.
The utility model provides a kind of connection structure of preparative scale chromatography column, as shown in Figure 1, including the end cap being sequentially communicated
1, connector 2, filter 3, take over 4 and conduit 5；The end cap 1 is tightly connected with connector 2 by the first sealing ring 6；It is described to take over
4 lower ends are equipped with the first groove 41, and the filter 3 and the size of the first groove 41 match, and the take over 4 passes through with connector 2
Second sealing ring 7 is tightly connected；The take over 4 is tightly connected with conduit 5；The filter 3 includes positioned at the first of upper surface
Filter membrane 31 and the second filter membrane 32 positioned at lower surface, the aperture of first filter membrane 31 is 0.45 μm, second filter membrane 32
Aperture is 0.22 μm.
The connection structure of preparative scale chromatography column provided by the utility model, during use, because carrying the first filter membrane 31
Be disposed in the first groove 41 of take over 4 with the filter 3 of the second filter membrane 32, so, in use, it is detachable and
It replaces, when carrying out preparative liquid chromatography lock out operation, without being individually filtered operation, shortens process, improve separation
Working efficiency.It is matched by the first filter membrane 31 with different pore size and the second filter membrane 32, in the high efficiency and flow of separation
Between achieve preferable balance.Furthermore the direction of the filter 3 have controllability, that is to say, that can according to connection structure with
The mode of chromatographic column is arranged in chromatographic column liquid feeding end, and the first filter membrane 31 is in the feed end of the second filter membrane 32, retention part
0.22-0.45 μm of minute impurities.
In the connection structure of the preparative scale chromatography column, connector 2 and take over 4 and connector 2 and end cap 1 are all using being tightly connected
Mode be attached, specifically, connector 2 and the connection type of take over 4 include but not limited to be threadedly coupled, be clamped or grafting；
Connector 2 and the connection type of end cap 1 include but not limited to be threadedly coupled, be clamped or grafting.Further, for operating easily,
The connector 2 includes first end 21 and the second end 22, and the first end 21 is threadedly coupled with the end cap 1, and described the
Two ends 22 and 4 threaded connection of the take over.
In the connection structure of the preparative scale chromatography column, the first sealing ring 6 makes the mode packet that end cap 1 is tightly connected with connector 2
Include interior sealing or external seal：1) outer diameter of the internal diameter and the first end 21 of first sealing ring 6 matches, i.e., first is close
Seal 6 is socketed on outside first end 21；2) end cap 1 is equipped with the second groove 11, the outer diameter of first sealing ring 6 and institute
The internal diameter for stating the second groove 11 matches, i.e., the first sealing ring 6 is set in the second groove 11.
In the connection structure of the preparative scale chromatography column, as shown in Fig. 2, the filter 3 includes being used to support described first
The bracing ring 33 of filter membrane 31 or the second filter membrane 32 and the casing 34 for fixing bracing ring 33.I.e. the support 3 filter membrane of filter,
The material for fixing the bracing ring 33 belongs to elastic material, and the material of bracing ring 33 is preferably TPU.
The above embodiment is only preferred embodiments of the present invention, cannot be protected with this to limit the utility model
Range, the variation of any unsubstantiality that those skilled in the art is done on the basis of the utility model and replacing belongs to
In the utility model range claimed.
Claims (7)
1. a kind of connection structure of preparative scale chromatography column, which is characterized in that including be sequentially communicated end cap, connector, filter, connect
Pipe and conduit；The end cap is tightly connected with connector by the first sealing ring；The lower end of taking over is equipped with the first groove, the mistake
The size of filter and the first groove matches, and described take over is tightly connected with connector by the second sealing ring；It is described to take over and lead
Pipe is tightly connected；The filter includes the first filter membrane positioned at upper surface and the second filter membrane positioned at lower surface, and described first
The aperture of filter membrane is 0.45 μm, the aperture of second filter membrane is 0.22 μm.
2. the connection structure of preparative scale chromatography column as described in claim 1, which is characterized in that the connector includes first end
And the second end, the first end are threadedly coupled with the end cap, the second end is threadedly coupled with described take over.
3. the connection structure of preparative scale chromatography column as claimed in claim 2, which is characterized in that it is recessed that the end cap is equipped with second
Slot, the outer diameter of first sealing ring and the internal diameter of second groove match.
4. the connection structure of preparative scale chromatography column as claimed in claim 2, which is characterized in that the internal diameter of first sealing ring
Match with the outer diameter of the first end.
5. the connection structure of preparative scale chromatography column as described in claim 1, which is characterized in that the filter includes for branch
Support the bracing ring of first filter membrane or the second filter membrane and the casing for fixing bracing ring.
6. the connection structure of preparative scale chromatography column as claimed in claim 5, which is characterized in that the bracing ring supports for TPU
Circle.
7. the connection structure of preparative scale chromatography column as claimed in claim 5, which is characterized in that described sleeve pipe is spring-backed quill.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721929539.0U CN207832752U (en) | 2017-12-30 | 2017-12-30 | A kind of connection structure of preparative scale chromatography column |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721929539.0U CN207832752U (en) | 2017-12-30 | 2017-12-30 | A kind of connection structure of preparative scale chromatography column |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207832752U true CN207832752U (en) | 2018-09-07 |
Family
ID=63391421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721929539.0U Active CN207832752U (en) | 2017-12-30 | 2017-12-30 | A kind of connection structure of preparative scale chromatography column |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN207832752U (en) |
-
2017
- 2017-12-30 CN CN201721929539.0U patent/CN207832752U/en active Active
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