CN207828306U - A kind of drop formula biological monitor - Google Patents
A kind of drop formula biological monitor Download PDFInfo
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- CN207828306U CN207828306U CN201820023217.8U CN201820023217U CN207828306U CN 207828306 U CN207828306 U CN 207828306U CN 201820023217 U CN201820023217 U CN 201820023217U CN 207828306 U CN207828306 U CN 207828306U
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- syringe
- test fluid
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- fixing bracket
- cleaning solution
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Abstract
The utility model discloses a kind of drop formula biological monitors, including detection pedestal, fixing bracket, syringe frame, test fluid syringe, cleaning solution syringe, driving mechanism and reactor, fixing bracket is fixedly mounted on the upper surface of detection pedestal, syringe frame is mounted on fixing bracket, and it can be moved along the horizontal stepping of fixing bracket, test fluid syringe is one or more, test fluid syringe, cleaning solution syringe is fixed on syringe frame, and it is arranged vertically downward, driving mechanism is mounted on fixing bracket, reactor is fixed in detection pedestal, the push rod of driving mechanism is located at the surface of reactor, syringe frame is in the horizontal stepping movement of fixing bracket, make push rod, required test fluid syringe, reactor is when on a vertical line, push rod pushes required test fluid syringe, the liquid in the test fluid syringe is set vertically to instill in reactor.The utility model is greatly reduced test fluid consumption and improves detection efficiency, has a good application prospect.
Description
Technical field
The utility model is related to biological detection instrument technical fields, and in particular to a kind of drop formula biological monitor.
Background technology
Currently, gene sequencing instrument on the market（Or other similar biological detection equipment）, supplied using continuous
The base reagent that gene sequencing needs is continuously introduced into reaction chip by liquid and the design of flushing.But due to gene extension
The time is needed, thus, within this section of reaction time, continuous liquor charging needs to consume a large amount of reagent, causes reagent costly, increases
A large amount of cost.Secondly, the mode of continuous liquid supply can also make liquid adjacent before and after two generate mixing interference.How to overcome
The above problem is current urgent problem.
Utility model content
The purpose of the utility model is to overcome it is existing be using continuous liquid supply and rinse design biological detection equipment institute
There are the problem of.The drop formula biological monitor of the utility model, fluid volume flexibly can be adjusted dynamically, and different liquids are kept away
Mixing interference is exempted from, testing process is flexible and convenient, and test fluid consumption is greatly reduced and improves detection efficiency, has good
Application prospect.
In order to achieve the above object, technical solution used by the utility model is：
A kind of drop formula biological monitor, including detection pedestal, fixing bracket, syringe frame, test fluid syringe, cleaning solution
Syringe, driving mechanism and reactor, the fixing bracket are fixedly mounted on the upper surface of detection pedestal, the test fluid syringe,
Cleaning solution syringe by syringe frame be arranged on fixing bracket, the test fluid syringe be one or more, the driving
Mechanism is mounted on fixing bracket, and the reactor is fixed in detection pedestal, driving mechanism driving test fluid syringe or
Person's cleaning solution syringe acts, and the liquid in the test fluid syringe or cleaning solution syringe is made vertically to instill in reactor.
A kind of drop formula biological monitor above-mentioned, the syringe frame are mounted on fixing bracket, and can be along fixed branch
The horizontal stepping movement of frame, the test fluid syringe is one or more, and the test fluid syringe, cleaning solution syringe are fixed on
On syringe frame, and it is arranged vertically downward, the push rod of the driving mechanism is located at the surface of reactor,
The syringe frame makes push rod, required test fluid syringe or cleaning solution needle in the horizontal stepping movement of fixing bracket
When on a vertical line, the push rod pushes required test fluid syringe or cleaning solution syringe, makes the test for cylinder, reactor
Liquid in liquid syringe or cleaning solution syringe vertically instills in reactor.
A kind of drop formula biological monitor above-mentioned, the test fluid syringe, cleaning solution syringe, driving mechanism are integrated
Multichannel micro-injection pump together, the multichannel micro-injection pump accurately control the liquid bulk instilled in reactor
Product, and automatically switch fluid passage and come to test fluid syringe or cleaning solution syringe fluid infusion.
A kind of drop formula biological monitor above-mentioned, the fixing bracket are equipped with step drive device, the stepping
Driving device control syringe frame is moved along the horizontal stepping of fixing bracket, is provided on the fixing bracket for carrying syringe frame water
The horizontal slide rail of flat stepping movement.
A kind of drop formula biological monitor above-mentioned, the driving mechanism in the step drive device be stepper motor,
Slide bar motor or piezo-electric device.
A kind of drop formula biological monitor above-mentioned, the driving mechanism further include driving cylinder, the driving cylinder
Control the rising or decline of push rod.
A kind of drop formula biological monitor above-mentioned is provided with vacuum pump and waste collection box in the detection pedestal,
Waste collection box is connected by the vacuum pump with reactor.
A kind of drop formula biological monitor above-mentioned, the upper surface of the detection pedestal are additionally provided with control panel, institute
State and controller system be set in detection pedestal, the controller system respectively with control panel, driving mechanism, vacuum pump, stepping
Driving device is connected.
The quantity of a kind of drop formula biological monitor above-mentioned, the test fluid syringe is four, is sequentially arranged with gene
Four kinds of base test fluids needed for sequencing instill the volume of base test fluid in reactor between 1nL to 1 μ L every time.
The utility model has the beneficial effects that：The drop formula biological monitor of the utility model, is generated using syringe
The discontinuous feed liquid way of drop makes each biochemical reaction all be realized in a drop, thus can largely reduce reagent
Usage amount saves cost, without mixing and cross contamination between liquid, after each feed flow and reaction, can be rinsed cleaning,
And the biological detection equipment of waste liquid is collected automatically, testing precision is provided, to each minimal amount of accurate feed flow of realization, every time
Offer test fluid not of the same race, every time test are cleaned automatically after the completion, waste liquid recycles, tests the function that can repeatedly recycle automatically, are used
Liquid measure flexibly can be adjusted dynamically, and testing process is flexible and convenient, and use injection needle wound packages liquid, can use existing medical treatment
Equipment saves consumables cost, test fluid consumption is greatly reduced and improves detection efficiency, has a good application prospect.
Description of the drawings
Fig. 1 is the structural schematic diagram of the drop formula biological monitor of the utility model.
The meaning marked in attached drawing is as follows：
1：Detection pedestal；2：Fixing bracket；3：Syringe frame；4：Test fluid syringe；5：Cleaning solution syringe；6：Driving mechanism；
601：Push rod；602：Drive cylinder；7：Reactor；8：Waste collection box；9：Control panel.
Specific implementation mode
Below in conjunction with Figure of description, the utility model is further described.
As shown in Figure 1, the drop formula biological monitor of the utility model, including detection pedestal 1, fixing bracket 2, syringe
Frame 3, test fluid syringe 4, cleaning solution syringe 5, driving mechanism 6 and reactor 7, the fixing bracket 2 are fixedly mounted on detection base
The upper surface of seat 1, the test fluid syringe 4, cleaning solution syringe 5 are arranged by syringe frame 3 on fixing bracket 2, the test
Liquid syringe 4 is one or more, and the driving mechanism 6 is mounted on fixing bracket 2, and the reactor 7 is fixed on detection
On pedestal 1, the driving mechanism 6 drives test fluid syringe 4, and either the action of cleaning solution syringe 5 makes the test fluid syringe 4 or clear
Liquid in washing lotion syringe 5 vertically instills in reactor 7.
The syringe frame 3 is mounted on fixing bracket 2, and can be moved along 2 horizontal stepping of fixing bracket, the test fluid needle
Cylinder 4 is one or more, and the test fluid syringe 4, cleaning solution syringe 5 are fixed on syringe frame 3, and set vertically downward
It sets, the push rod 601 of the driving mechanism 6 is located at the surface of reactor 7,
The syringe frame 3 is moved in 2 horizontal stepping of fixing bracket, makes push rod 601, required test fluid syringe 4 or clear
When on a vertical line, the push rod 601 pushes required test fluid syringe 4 or cleaning solution for washing lotion syringe 5, reactor 7
Syringe 5 makes the liquid in the test fluid syringe 4 or cleaning solution syringe 5 vertically instill in reactor 7.
Preferably, the fixing bracket 2 is equipped with step drive device, 3 edge of step drive device control syringe frame
2 horizontal stepping of fixing bracket is moved, and the level for carrying 3 horizontal stepping of syringe frame movement is provided on the fixing bracket 2
Sliding rail 201, the driving mechanism in the step drive device is stepper motor, slide bar motor or piezo-electric device, using stepping
The position of syringe frame 3 is controlled, control efficiency is high, and does not allow error-prone.
Preferably, the driving mechanism 6 further includes driving cylinder 602, and the driving cylinder 602 controls the upper of push rod 601
It rises or declines, using pneumatic source, control effect is good, at low cost, can be iteratively repeated use.
Preferably, another embodiment of the utility model, the test fluid syringe 4, cleaning solution syringe 5, driving mechanism 6
It is integrated in multichannel micro-injection pump together, such as the Smart Syringe Pump of Parker companies or Baoding orchid
Lattice industry multichannel injection pump SP4-E1 etc., the multichannel micro-injection pump accurately control the liquid bulk instilled in reactor 7
Product, and fluid passage can be automatically switched and come to 5 fluid infusion of test fluid syringe 4 or cleaning solution syringe, continuously to make for a long time
With.
Preferably, vacuum pump and waste collection box 8 are provided in the detection pedestal 1, the vacuum pump is by waste collection
Box 8 is connected with reactor 7.
Preferably, the upper surface of the detection pedestal 1 is additionally provided with control panel 9, and control is arranged in the detection pedestal 1
Device system, the controller system are connected with control panel 9, driving mechanism 6, vacuum pump, step drive device respectively, automatically
Change degree is high.
Preferably, the quantity of the test fluid syringe 4 is four, is sequentially arranged with four kinds of bases test needed for gene sequencing
Liquid instills the volume of base test fluid in reactor 7 between 1nL to 1 μ L every time（Here volume is according to 7 core of reactor
Depending on the size and volume of piece）, the embodiments of the present invention, four kinds of base test fluids are respectively dNTP（A、T、G、C）, can
Complete the effect of existing gene sequencer.
The drop formula biological detecting method of the utility model, includes the following steps：
Step（A）, multiple test fluid syringes 4 for placing different test fluids and the cleaning solution syringe 5 for placing cleaning solution are consolidated
Dingan County is attached on syringe frame 3；
Step（B）, according to the sequence requirement of biological detection experiment test liquid, step motion control syringe frame 3 is in detection pedestal 1
Position, make the push rod 601, required test fluid syringe 4, reactor 7 of driving mechanism 6 when on a vertical line, it is described to push away
Bar 601 pushes required test fluid syringe 4, and the liquid in the test fluid syringe 4 is made vertically to instill in reactor 7；
Step（C）, after the completion of reaction（Here reaction time range, depending on the type of biological detection experiment, gene
The sequencing time is short, and the gene recombination time is long）, control vacuum pump will be in the waste collection after reaction to waste collection box 8；
Step（D）, reactor 7 after reaction, position of the step motion control syringe frame 3 in detection pedestal 1 makes driving
When on a vertical line, the push rod 601 pushes cleaning solution syringe for the push rod 601 of mechanism 6, cleaning solution syringe 5, reactor 7
5, so that the clear liquid body of the cleaning solution syringe 5 is vertically instilled in reactor 7, is cleaned；
Step（E）, after the completion of cleaning, control vacuum pump will be in the waste collection of cleaning to waste collection box 8；
Step（F）, repeat step（B）Step（E）, until completing biological detection experiment.
When biological detection experiment is gene sequencing, the quantity of test fluid syringe 4 is four, is sequentially arranged with gene sequencing institute
The four kinds of base test fluids needed instill the volume of base test fluid in reactor 7 between 1nL to 1 μ L every time（Here volume is
Depending on the size of 7 chips of reactor and volume）, to realize the function of gene sequencing device, this is the utility model
One embodiment, be suitable for the biological detection experiment of other similar gene sequencing experiments.
In conclusion the drop formula biological monitor of the utility model, the discontinuous confession of drop is generated using syringe
Liquid mode makes each biochemical reaction all be realized in a drop, thus can largely reduce the usage amount of reagent, save at
This, after each feed flow and reaction, can be rinsed cleaning, and collect the biological detection equipment of waste liquid automatically, provide test essence
Exactness, thus after the completion of realizing every time minimal amount of accurate feed flow, each offer test fluid not of the same race, each test automatically clearly
Wash, waste liquid recycles automatically, tests the function that can repeatedly recycle, fluid volume flexibly can be adjusted dynamically, testing process flexibly side
Just, and injection needle wound packages liquid is used, existing medical equipment can be used, save consumables cost, test fluid consumption is greatly reduced
Detection efficiency is measured and improved, is had a good application prospect.
The basic principles and main features and advantage of the utility model have been shown and described above.The technical staff of the industry
It should be appreciated that the present utility model is not limited to the above embodiments, the above embodiments and description only describe this
The principle of utility model, on the premise of not departing from the spirit and scope of the utility model, the utility model also has various change
And improvement, these various changes and improvements fall within the scope of the claimed invention.The utility model requires protection scope
It is defined by the appending claims and its equivalent thereof.
Claims (9)
1. a kind of drop formula biological monitor, it is characterised in that：Including detection pedestal（1）, fixing bracket（2）, syringe frame
（3）, test fluid syringe（4）, cleaning solution syringe（5）, driving mechanism（6）And reactor（7）, the fixing bracket（2）Fixed peace
Mounted in detection pedestal（1）Upper surface, the test fluid syringe（4）, cleaning solution syringe（5）Pass through syringe frame（3）Setting is solid
Fixed rack（2）On, the test fluid syringe（4）For one or more, the driving mechanism（6）Mounted on fixing bracket
（2）On, the reactor（7）It is fixed on detection pedestal（1）On, the driving mechanism（6）Drive test fluid syringe（4）Or it is clear
Washing lotion syringe（5）Action, makes the test fluid syringe（4）Or cleaning solution syringe（5）Interior liquid vertically instills reactor（7）
It is interior.
2. a kind of drop formula biological monitor according to claim 1, it is characterised in that：The syringe frame（3）Installation
In fixing bracket（2）On, and can be along fixing bracket（2）Horizontal stepping movement, the test fluid syringe（4）For one or one with
On, the test fluid syringe（4）, cleaning solution syringe（5）It is fixed on syringe frame（3）On, and be arranged vertically downward, the driving machine
Structure（6）Push rod（601）Positioned at reactor（7）Surface,
The syringe frame（3）In fixing bracket（2）Horizontal stepping movement, makes push rod（601）, required test fluid syringe（4）Or
Person's cleaning solution syringe（5）, reactor（7）When on a vertical line, the push rod（601）Test fluid syringe needed for pushing
（4）Or cleaning solution syringe（5）, make the test fluid syringe（4）Or cleaning solution syringe（5）Interior liquid vertically instills reactor
（7）It is interior.
3. a kind of drop formula biological monitor according to claim 2, it is characterised in that：The fixing bracket（2）Peace
Equipped with step drive device, the step drive device controls syringe frame（3）Along fixing bracket（2）Horizontal stepping movement, it is described
Fixing bracket（2）On be provided with for carrying syringe frame（3）The horizontal slide rail of horizontal stepping movement（201）.
4. a kind of drop formula biological monitor according to claim 3, it is characterised in that：In the step drive device
Driving mechanism be stepper motor, slide bar motor or piezo-electric device.
5. a kind of drop formula biological monitor according to claim 2, it is characterised in that：The driving mechanism（6）Also
Including driving cylinder（602）, the driving cylinder（602）Control push rod（601）Rising or decline.
6. a kind of drop formula biological monitor according to claim 1, it is characterised in that：The test fluid syringe（4）、
Cleaning solution syringe（5）, driving mechanism（6）For the multichannel micro-injection pump integrated, the multichannel micro-injection pump
Accurately control instillation reactor（7）Interior liquid volume, and fluid passage is automatically switched to give test fluid syringe（4）Or
Cleaning solution syringe（5）Fluid infusion.
7. a kind of drop formula biological monitor according to claim 1, it is characterised in that：The detection pedestal（1）It is interior
It is provided with vacuum pump and waste collection box（8）, the vacuum pump is by waste collection box（8）With reactor（7）It is connected.
8. a kind of drop formula biological monitor according to claim 1, it is characterised in that：The detection pedestal（1）'s
Upper surface is additionally provided with control panel（9）, the detection pedestal（1）Interior setting controller system, the controller system difference
With control panel（9）, driving mechanism（6）, vacuum pump, step drive device be connected.
9. a kind of drop formula biological monitor according to claim 1, it is characterised in that：The test fluid syringe（4）
Quantity be four, be sequentially arranged with four kinds of base test fluids needed for gene sequencing, instill reactor every time（7）Interior base test
The volume of liquid is between 1nL to 1 μ L.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820023217.8U CN207828306U (en) | 2018-01-08 | 2018-01-08 | A kind of drop formula biological monitor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820023217.8U CN207828306U (en) | 2018-01-08 | 2018-01-08 | A kind of drop formula biological monitor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207828306U true CN207828306U (en) | 2018-09-07 |
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ID=63391882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201820023217.8U Active CN207828306U (en) | 2018-01-08 | 2018-01-08 | A kind of drop formula biological monitor |
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| Country | Link |
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| CN (1) | CN207828306U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108117981A (en) * | 2018-01-08 | 2018-06-05 | 张家港万众芯生物科技有限公司 | A kind of drop formula biological monitor and method |
| CN110540935A (en) * | 2019-09-09 | 2019-12-06 | 成都万众壹芯生物科技有限公司 | Novel gene sequencer |
-
2018
- 2018-01-08 CN CN201820023217.8U patent/CN207828306U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108117981A (en) * | 2018-01-08 | 2018-06-05 | 张家港万众芯生物科技有限公司 | A kind of drop formula biological monitor and method |
| CN110540935A (en) * | 2019-09-09 | 2019-12-06 | 成都万众壹芯生物科技有限公司 | Novel gene sequencer |
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