CN102507964B - Full-automatic reactor - Google Patents
Full-automatic reactor Download PDFInfo
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- CN102507964B CN102507964B CN201110339028.4A CN201110339028A CN102507964B CN 102507964 B CN102507964 B CN 102507964B CN 201110339028 A CN201110339028 A CN 201110339028A CN 102507964 B CN102507964 B CN 102507964B
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Abstract
The invention relates to a full-automatic reactor, which comprises a translation mechanism, a holding platform, an incubator component, an oscillating mechanism, a cleaning mechanism, an electrical unit, a shell component and a bottom plate. The holding platform comprises a holding table and a holding table support component; the holding table is bilaterally, elastically and slidably connected onto the holding table support component; the holding table support component of the holding platform is bilaterally and slidably connected onto the bottom plate through the translation mechanism; the incubator component comprises an incubator with a leftward opening, and an incubator base which is fixed onto the bottom plate from the upper side and positioned above the translation mechanism and on the right of the holding platform; the oscillating mechanism is arranged on the right of the incubator; an oscillating part of the oscillating mechanism extends into the incubator; the cleaning mechanism comprises a cleaning head, a lifting device and a pump unit; and the cleaning head is vertically and slidably connected onto the bottom plate through the lifting device. The reactor is used for cleaning, oscillating and reacting protein membrane chips or microtiter plates.
Description
Technical field
The present invention relates to robotization cleaning, consersion unit in a kind of clinical medical inspection and chemical analysis, be particularly useful for cleaning, vibration and the reaction of protein film chip or ELISA Plate.
Background technology
Protein film chip is that protein is fixed on the film medium carrier in an orderly manner, and making it becomes the biochip that detects use, then it is carried out to the immune detection analysis.Protein film chip can be used the chemiluminescence enzyme immunoassay method to detect analysis, its principle for mark the antibody of horseradish peroxidase (antigen) and chip effect, the antibody (antigen) be complementary with protein on chip is after immune response occurs in antigen (antibody) corresponding thereto, form the solid-phase coating compound, after washing, add luminous agent, the enzymatic luminous agent is luminous, goes out to measure subsequently the concentration of thing by gathering the light signal computable analysis.
In the experiment of protein film chip or enzyme linked immunoassay, adopt rational cleaning way, reacting fully is to guarantee its result necessary condition accurately and reliably.The cleaning of ELISA Plate and reaction are to react additional ELIAS microplate washer by constant-temperature table to realize mostly, and experimental period is long, complex operation, and the use of multiple devices has also strengthened the inaccuracy of experimental result.At present, a large amount of ELIAS microplate washers is arranged on market, but but be not directed to the cleaning products of protein film chip.
Chinese patent literature CN1825115A(application number is: 200510024038.3) announced a kind of biochip reaction apparatus and included main box, objective table, temperature-controlling reaction apparatus and liquid crystal display, be provided with control circuit board, pump, solenoid valve, pressure adjustment assembly, vertical movement mechanism and horicontal motion mechanism in main box, cleaning head is connected in vertical movement mechanism, and objective table is connected in horicontal motion mechanism.Objective table one side is provided with temperature-controlling reaction apparatus, the casing of this device is comprised of multiple layer heat proof material, equally distributed heater members is arranged in interlayer, air circulation device and a plurality of temperature sensor are set in casing, the casing antetheca arranges a dodge gate, while making objective table drive chip carry out oscillating reactions in casing, it is airtight that casing keeps.This patent documentation is because it does not disclose the concrete structure of objective table and temperature-controlling reaction apparatus, so can't obtaining objective table from patent document, those skilled in the art how to keep the horizontality that is installed, how objective table is realized collecting the waste liquid function, and the objective table technical scheme of how to be vibrated.
Summary of the invention
The purpose of this invention is to provide a kind of easy to operately, result is accurate, for the full-automatic reaction instrument of cleaning, vibration and the reaction of protein film chip or ELISA Plate.
A kind of technical scheme that realizes the object of the invention is to provide a kind of full-automatic reaction instrument and comprises translation mechanism, article carrying platform, constant temperature oven parts, oscillating mechanism, wiper mechanism, electric unit, case member and base plate;
Translation mechanism is arranged on the front portion of base plate from top; Article carrying platform comprises objective table and stage carrier assembly, and objective table is connected on the stage carrier assembly along left and right to Elastic Sliding; The stage carrier assembly of article carrying platform by about translation mechanism to being slidably connected on base plate; The constant temperature oven parts comprise constant temperature oven and constant temperature oven base, and the constant temperature oven opening left, is fixed on the constant temperature oven base, and the constant temperature oven parts are fixed on base plate from top by its constant temperature oven base, and are positioned at the top of translation mechanism, the right side of article carrying platform; Oscillating mechanism is arranged on the right side of constant temperature oven, and the oscillating member of oscillating mechanism stretches in constant temperature oven; Wiper mechanism comprises cleaning head, jacking gear and pump assembly; Cleaning head is slidably connected on base plate by the jacking gear upward and downward, and is positioned at the left back section of base plate; The pump assembly is that the parts of feed liquor, imbibition power are provided for cleaning head; Electric unit is arranged on the right back section of base plate; Case member comprises upper casing, touch-screen parts and lower casing; The left front section of upper casing offers gathering hole, and the right part of upper casing offers the touch-screen installing port, and the touch-screen parts are arranged on touch-screen installing port place; Lower casing is fixed on base plate from below; Upper casing is airtight being fixed on lower casing from top;
Electric unit is the parts that electric power are provided, controlled for translation mechanism, constant temperature oven parts, oscillating mechanism, wiper mechanism, and the touch-screen parts are signal input parts of electric unit.
Cleaning positions or the vibration position in right side that in use, article carrying platform can be in left side; Article carrying platform is when cleaning positions, and article carrying platform is positioned at the below of gathering hole, and cleaning head is positioned at the top of objective table; Article carrying platform is when the vibration position, and article carrying platform is arranged in constant temperature oven, and oscillating member contacts with objective table.
Above-mentioned full-automatic reaction instrument also comprises bottle for handling liquid toilet or cosmetic substance, waste liquid bottle and surge flask;
The cleaning head of above-mentioned wiper mechanism comprises cleaning head main body, water injection pipe, suction hose, water filling interface, water outlet mouthpiece; The cleaning head main body is strip, along front and back to being horizontally disposed with; Water filling interface, water outlet mouthpiece all are arranged on the top of cleaning head main body; Water injection pipe has 6 to 12, vertically arranges, along front and back to being arranged in a row; Each root water injection pipe is fixedly connected on the bottom of cleaning head main body by its top, each root water injection pipe is connected with the water filling interface; The quantity of suction hose is identical with the quantity of water injection pipe, vertically arranges, along front and back to being arranged in a row; Each root suction hose is fixedly connected on the bottom of cleaning head main body by its top, and is positioned at the right side of corresponding separately water injection pipe, and each root suction hose is connected with water outlet mouthpiece; The length of water injection pipe is less than the length of suction hose, and the caliber of water injection pipe is less than the caliber of suction hose;
The pump assembly of above-mentioned wiper mechanism comprises liquid charge pump, impact damper, solenoid valve and suction pumps; Washing lotion is housed in bottle for handling liquid toilet or cosmetic substance, stretches in the washing lotion of bottle for handling liquid toilet or cosmetic substance with the airtight flexible pipe be connected of the inlet of liquid charge pump; The liquid outlet of liquid charge pump is connected with the inlet of impact damper is airtight by flexible pipe; The liquid outlet of impact damper is by airtight being connected of water filling interface of flexible pipe with cleaning head through solenoid valve; The water outlet mouthpiece of cleaning head is connected by flexible pipe and waste liquid bottle are airtight; Waste liquid bottle is connected by flexible pipe and surge flask are airtight; Surge flask is connected with the air intake opening with suction pumps is airtight by flexible pipe.
Above-mentioned cleaning head also comprises the cleaning head support; Cleaning head is fixed on the cleaning head support by its cleaning head main body; The front-end and back-end on the right side of cleaning head support are provided with hook;
The jacking gear of above-mentioned wiper mechanism comprises framework, riser guide parts, elevating screw parts, lifting motor, lifting driving member, lifting sensing chip and lifting optoelectronic switch;
Framework comprises framework front side board, framework back side panel, frame head plate, chassis base; The front end of frame head plate is fixedly connected with the upper end of framework back side panel with the rear end of framework front side board plate, and the front end of chassis base is fixedly connected with the lower end of framework front side board, and the rear end of chassis base is fixedly connected with the lower end of framework back side panel;
The riser guide parts comprise riser guide, lifting slider and lifter plate; The riser guide upward and downward is horizontally disposed with, and is fixed on the framework back side panel from the place ahead, and is positioned at the right part of framework back side panel; Lifting slider is arranged on riser guide, can slide up and down along riser guide; Lifter plate is fixed on lifting slider from the place ahead;
The elevating screw parts comprise elevating screw, elevating screw nut, lifting holder, elevating screw bearing; The lifting fixed seating is on the elevating screw nut, and the elevating screw nut is fixed on the lifting holder; The lifting holder is fixed on lifter plate from the place ahead; The right part of frame head plate offers the dead eye of up/down perforation, and the elevating screw bearing is fixed on this dead eye place; Elevating screw vertically arranges, and through the elevating screw nut, and is meshed with the elevating screw nut; The upper end of elevating screw, through the elevating screw bearing, protrude upward;
The left part of frame head plate offers the motor hole of up/down perforation; Lifting motor is fixed on the frame head plate left part from below; The upper end of the motor shaft of lifting motor through the motor hole of frame head plate, protrudes upward from bottom to top;
The lifting driving member comprises lifting synchronous pulley and lifting Timing Belt; The lifting synchronous pulley has 2, and wherein 1 lifting synchronous pulley is enclosed within on the upper end of elevating screw, and is fixedly connected with elevating screw, and another 1 lifting synchronous pulley is enclosed within on the motor shaft of lifting motor, and is fixedly connected with the motor shaft of lifting motor; The lifting Timing Belt is enclosed within on 2 lifting synchronous pulleys, and is meshed with the lifting synchronous pulley;
Crane comprises crane substrate and crane crossbeam; The crane substrate vertically arranges, and before and after the crane crossbeam, to being horizontally disposed with, the crane crossbeam is connected to the top of crane substrate by its rear end; Front end and the middle part of crane crossbeam are equipped with hook portion, and the hook of cleaning head support is stuck in the hook portion of crane crossbeam; Crane by its crane substrate from the right-hand right side that is fixed on the lifting holder;
The lifting sensing chip is fixed on the lifting holder, and is positioned at the upper left quarter of the front side of lifting holder; The lifting optoelectronic switch has 3, all from the place ahead, is fixed on the framework front side board; The lifting sensing chip is to match with the lifting optoelectronic switch, the electrical equipment of feedback lifting position signal;
The pump assembly of above-mentioned wiper mechanism also comprises bumper support and pump groove; The pump channel opening upwards, is fixed on the left back section of base plate; Suction pumps and liquid charge pump all are positioned at the pump groove, and are fixed on the pump groove; The main body of bumper support is horizontally disposed with, and its right part bends downwards, and bumper support is fixed on frame head plate by its right lateral bend folding part; Impact damper is fixed on the left part of bumper support from below, solenoid valve is fixed on the middle part of bumper support from below.
Above-mentioned article carrying platform also comprises rinse bath, 2 guide rods, 4 guide pin bushings, 2 stage clips, sealing gasket, pressing plate and baffle plates;
Objective table comprises objective table main body and 2 objective table slide blocks; The upper surface of objective table main body offers a stopper slot and 1 waste liquid tank; Waste liquid tank be shaped as strip, front and back, to setting, are positioned at the right side of stopper slot; The bottom of stopper slot and waste liquid tank offer 3 to 10 left and right to arrange by stopper slot and diversion trench together with waste liquid tank is interconnected; All one in front and one in back offer 2 left and right to the circular hole connected on 2 objective table slide blocks; 2 objective table slide blocks are divided into left side objective table slide block and right side objective table slide block, left side objective table slide block is connected to the objective table main body from below, and be positioned at the left side central portion of objective table main body, right side objective table slide block is connected to the objective table main body from below, and is positioned at the right side central of objective table main body; Baffle plate vertically arranges, from the right-hand right flank that is fixed on the objective table main body;
The stage carrier assembly comprises fore-stock, after-poppet, left side tie-beam, middle part tie-beam and right side tie-beam; The shape of fore-stock and after-poppet is identical, includes foot rest and crossbeam separately, and crossbeam is connected to the top of foot rest by its left end head; Fore-stock and after-poppet one in front and one in back are symmetrical arranged; Left side tie-beam, middle part tie-beam and right side tie-beam all before and after to setting, and according to order from left to right, be sequentially arranged between the crossbeam of the crossbeam of fore-stock and after-poppet; The front end of left side tie-beam, middle part tie-beam and right side tie-beam all is fixedly connected on the crossbeam of fore-stock, and the rear end of left side tie-beam, middle part tie-beam and right side tie-beam all is fixedly connected on the crossbeam of after-poppet;
The rinse bath opening upwards, be fixed on the fore-stock and after-poppet of stage carrier assembly, and be positioned at the upper right side of stage carrier assembly; Sealing gasket and pressing plate all vertically arrange, the right flank setting of the adjacent rinse bath of sealing gasket, and pressing plate is positioned at the right-hand of sealing gasket, and pressing plate is fixed on rinse bath from right-hand;
4 guide pin bushings are separately fixed in 2 circular holes of 2 circular holes of left side objective table slide block and right side objective table slide block; 2 guide rods are all along left and right to being horizontally disposed with, and respectively from left to right successively through guide pin bushing and right side tie-beam on the guide pin bushing on left side tie-beam, sealing gasket, pressing plate, left side objective table slide block, middle part tie-beam, corresponding stage clip, right side objective table slide block, and with left side tie-beam, middle part tie-beam and right side tie-beam wringing fit; The left end head of 2 stage clips contacts with the middle part tie-beam, and the right-hand member head of 2 stage clips contacts with right side objective table slide block; Objective table is slidably connected on guide rod by guide pin bushing, and stage clip applies direction power to the right to objective table all the time by self elastic force.
Above-mentioned translation mechanism comprises translation track segment, translation base plate, translation screw mandrel parts, translation motor parts and translation driving member;
The translation track segment comprises translation guide rail, translation slide block and right side block; Translation guide rail left and right, to being horizontally disposed with, being fixed on base plate from top, and being positioned at the front portion of base plate; The translation slide block is arranged on the translation guide rail; The right side block comprises riser, horizontal base plate and base, and horizontal base plate is connected with the top of riser by its left part, and base is connected with the bottom of riser by its left part; The right side block is fixed on base plate by its base, and the right-hand member of adjacent translation guide rail;
Being fixedly connected on the translation slide block from top of translation base plate; Article carrying platform is fixed on the translation base plate from top by its stage carrier assembly;
Translation screw mandrel parts comprise translation screw mandrel, translation feed screw nut, translation holder, peaceful silk shifting rod bearing; The translation fixed seating is on the translation feed screw nut, and the translation feed screw nut is fixed on the translation holder; The translation holder is fixed on the translation base plate from top; Have through hole on the riser of the right side block of translation track segment, translation screw mandrel bearing is fixed on the through hole of riser; Translation screw mandrel left and right, to being horizontally disposed with, through the translation feed screw nut, and is meshed with the translation feed screw nut; The right-hand member head of translation screw mandrel, through translation screw mandrel bearing, stretch out to the right;
The translation motor parts comprise translation motor and translation motor cabinet; Offer the motor hole that left and right connects on the translation motor seat; The translation motor seat is fixed on base plate from top, and is positioned at the rear of the right side block of translation track segment; Translation motor is fixed on the translation motor seat from left, and the right-hand member head of the motor shaft of translation motor through the motor hole on the translation motor seat, stretches out to the right from left to right;
The translation driving member comprises translation synchronous pulley and translation Timing Belt; The translation synchronous pulley has 2, and wherein 1 translation synchronous pulley is enclosed within on the right-hand member head of translation screw mandrel, and is fixedly connected with the translation screw mandrel, and another 1 translation synchronous pulley is enclosed within on the motor shaft of translation motor, and is fixedly connected with the motor shaft of translation motor; The translation Timing Belt is enclosed within on 2 translation synchronous pulleys, and is meshed with the translation synchronous pulley.
Above-mentioned full-automatic reaction instrument also comprises and connects liquid bath; Connect liquid bath and be top and right-hand all unlimited box bodys, connect on the base plate of liquid bath and offer along left and right to the strip hole arranged, the right-hand member of strip communicates with the right side boundary of the base plate that connects liquid bath, the width in strip hole equals the width of translation guide rail, and the edge of the edge in strip hole and the base plate that connects liquid bath is equipped with the flanging that the direction that is connected makes progress; Connect liquid bath and be fixed on base plate from top, and be positioned at the left front section of base plate, left section of the translation guide rail is positioned at the strip hole that connects liquid bath, and the base plate that connects liquid bath is positioned at the below of translation base plate and left side block.
Above-mentioned constant temperature oven parts comprise constant temperature oven, constant temperature oven base, temperature inductor and translation optoelectronic switch;
Constant temperature oven comprises constant temperature oven shell, constant temperature oven inner bag, constant temperature oven fan, constant temperature oven junction block and constant temperature oven upper cover; The constant temperature oven shell is all unlimited box bodys of top and left, and the front and rear of the right plate of constant temperature oven shell is equipped with the fan installation portion of projection to the right; The constant temperature oven inner bag comprises heating cabinet, left plate, right plate and crossbeam; The inner chamber left and right of heating cabinet, to perforation, is provided with heating arrangement between the inner and outer wall of heating cabinet; The central position of left plate and right plate all offers the through hole identical with the inner chamber size of heating cabinet; Left plate vertically arranges, and is fixed on heating cabinet by the edge of its through hole, and is positioned at the left side of heating cabinet, and the through hole on left plate is the opening of constant temperature oven; Right plate vertically arranges, and is fixed on heating cabinet by the edge of its through hole, and is positioned at the right side of heating cabinet; Before and after crossbeam, to being horizontally disposed with, its front end is connected to the forward edge place of the through hole of right plate, and its rear end is connected to the posterior edges place of the through hole of right plate, thereby the through hole of right plate is divided into to upper and lower two parts; The constant temperature oven inner bag is positioned at the constant temperature oven shell, and the left plate of constant temperature oven inner bag is positioned at the left side opening part of incubator shell, the fan installation portion of the adjacent constant temperature oven shell of the right plate of constant temperature oven inner bag; The constant temperature oven fan has 2, is separately fixed in the corresponding fan installation portion of constant temperature oven shell; 2 constant temperature oven fans are horizontally disposed with, and are positioned at the right side of the crossbeam of constant temperature oven inner bag, and air-out direction is downward; Junction block is fixed on the back side panel of constant temperature oven shell; The airtight upper opening place that is fixed on the constant temperature oven shell of constant temperature oven upper cover;
The constant temperature oven base comprises seat board, left front leg, right front leg, left back leg and right back leg; Left front leg, right front leg, left back leg and right back leg are connected to seat board from below by its upper end, and lay respectively at left side front end, right side front end, rear end, left side and the rear end, right side of seat board; The constant temperature oven base is fixed on the bottom of constant temperature oven shell by its seat board;
The probe of temperature inductor is through the right plate of constant temperature oven shell, stretches in the inner chamber of heating cabinet of constant temperature oven inner bag, and temperature inductor is fixed on the right plate of constant temperature oven shell by its pedestal;
The translation optoelectronic switch has 3, is divided into translation limit on the left switch, translation origin switch and translation limit on the right-right-hand limit switch; Translation limit on the left switch is fixed on the left front leg of constant temperature oven base from rear; Translation origin switch and translation limit on the right-right-hand limit switch all are fixed on the right front leg of constant temperature oven base from rear, and the translation origin switch is positioned at the left side of translation limit on the right-right-hand limit switch;
Translation mechanism also comprises the translation sensing chip; The translation sensing chip is fixed on the translation base plate from top, and is positioned at the right front portion of translation base plate, and the front side of translation sensing chip is provided with protuberance, and its protuberance is positioned at outside the translation base plate; Translation sensing chip on the translation base plate is to match with the translation optoelectronic switch, the electrical equipment of feedback translation position signalling;
The constant temperature oven parts are fixed on base plate from top by the left front leg of its constant temperature oven base, right front leg, left back leg and right back leg, and be positioned at the translation guide rail top, connect the right side of liquid bath.
Above-mentioned oscillating mechanism also comprises vibration motor, vibration motor installing plate, vibration support, eccentric wheel, vibration bearing, vibration cam, vibration connecting rod and lining; The vibration push rod is the oscillating member of oscillating mechanism;
The vibration support comprises vibration stent substrate and vibration rack side plate, and the vibration rack side plate, along front and back to vertical setting, is connected to the left end of vibration stent substrate from top, on the vibration rack side plate, offers left and right to the circular hole connected; Lining passes the circular hole on the vibration rack side plate, and is fixed on the vibration rack side plate; The vibration motor installing plate is along left and right to vertical setting, and the vibration motor installing plate is fixed on the vibration stent substrate from top, and is positioned at vibration stent substrate rear side, offers front and back on the vibration motor installing plate to the hole connected; Vibration motor 41 is fixed on the vibration motor installing plate, and is positioned at the rear of vibration motor installing plate 42; The motor shaft of vibration motor, through the hole on the vibration motor installing plate, stretches out forward; Eccentric wheel is fixed on the front end of motor shaft of vibration motor, and before and after eccentric front side is provided with, to horizontally disposed axle, the front end of axle is provided with screw thread; Vibration bearing axial limiting is on eccentric axle; The vibration cam comprises round plate and is arranged on the protuberance in round plate left side, and the central authorities of round plate offer circular hole, the vibration cam by the circle hole sleeve of its round plate on the vibration bearing, and with the outer ring wringing fit of vibration bearing; The vibration connecting rod is along the left and right horizontal setting, and the right-hand member of vibration connecting rod is hinged with the left end of the protuberance of vibration cam; The vibration push rod is along the left and right horizontal setting, and the right-hand member of vibration push rod is fixedly connected on the left end of vibration connecting rod by fixed pin, and the vibration push rod stretches out to the right through lining;
Oscillating mechanism is fixed on the right side block of translation track segment from top by the vibration stent substrate of its vibration support, and is positioned at the top of right side block; The right plate of the constant temperature oven shell of the adjacent constant temperature oven of vibration rack side plate of oscillating mechanism; The position between 2 fan installation portions of the right plate of constant temperature oven shell offers push-rod hole, and lining is through the push-rod hole of constant temperature oven shell, and the vibration push rod stretches in the constant temperature oven inner bag of constant temperature oven.
Above-mentioned case member also comprises left cover, right cover, power supply fan and feet;
Upper casing is the downward housing of lumen openings, and the right part of the back side panel of upper casing offers thermovent; Left cover and right cover is all transparent; Left cover is rotatably connected on upper casing by its rear end, and is positioned at the top of upper casing left part; Right cover is rotatably connected on upper casing by its rear end, and is positioned at the top of upper casing right part; Power supply fan is fixed on the thermovent place of upper casing, and air-out direction backward;
Lower casing is the housing that lumen openings makes progress, and the left side of lower casing and right side are equipped with the carrying attacker section concaved, and feet has individual, all from below, is fixed on lower casing, and lays respectively at the left front section of lower casing, left back section, right front portion and right back section.
Above-mentioned case member also comprises lock buckling part; Lock buckling part comprises snap close, snap close pressing plate, snap close bearing and snap close bearing axle; The snap close bearing is fixed on upper casing, and is positioned at the left back section of upper casing, the left side of left cover; Snap close bearing axle left and right, to being horizontally disposed with, is fixed on the snap close bearing by its left end; The left part of snap close is provided with the buckle that direction arranges downward vertically, and buckle is provided with opening groove forward, and the position of this groove is corresponding with the position of snap close bearing axle; The left back section of left cover offers the sagittal groove that slides, and the place ahead of sliding groove of left cover is provided with the downward front side reference column of direction, and the rear of sliding groove of left cover is provided with the downward rear side reference column of direction; The front end of snap close pressing plate is provided with front card interface, and the rear end of snap close pressing plate is provided with rear card interface; The snap close pressing plate is fixed on snap close through the groove that slides of left cover.
The present invention has positive effect:
(1) full-automatic reaction instrument of the present invention integrates isothermal reaction process and washing process, simplified operation, improved automaticity, reduced personal error, can disposablely complete the pre-service before protein film chip or ELISA Plate detect, improve accuracy and the repeatability of testing result.
(2) full-automatic reaction instrument circuit design of the present invention is succinct, adopts double-pump type liquid sucking-discharging mode, and is provided with impact damper, solenoid valve, and the effect of cleaning improves greatly, has saved number of times and the time of cleaning, and has been not easy to occur line clogging.This reaction instrument also is provided with surge flask, prevents that waste liquid bottle from overflowing and pollute due to the waste liquid overfill.
(3) jacking gear of full-automatic reaction instrument of the present invention adopts the mode that is slidably connected of guide rail, slide block, adopts screw mandrel, feed screw nut's the kind of drive, and mobile degree of accuracy is high, stable, has guaranteed the reliability of cleaning process.Jacking gear has also adopted the structure of synchronous belt pulley transmission simultaneously, has reduced the height of whole device, has effectively controlled the volume of whole instrument.
(4) article carrying platform of full-automatic reaction instrument of the present invention fully takes into account the needs of oscillation cleaning and constant temperature oscillation process when design, be provided with the automatic cleaning of rinse bath for cleaning head, the be installed horizontality of protein film chip or ELISA Plate of article carrying platform is high, when the vibration position, can constant temperature oven be sealed by sealing gasket, the elastic sliding structure of the objective table of article carrying platform is reasonable in design, and objective table carried out light-weight design, its, more be convenient to vibration, long service life.
(5) translation mechanism of full-automatic reaction instrument of the present invention adopts the mode that is slidably connected of guide rail, slide block, adopts screw mandrel, feed screw nut's the kind of drive, and mobile degree of accuracy is high, stable, has guaranteed the instrument reliability of operation.Translation mechanism has also adopted the structure of synchronous belt pulley transmission simultaneously, has shortened the length of whole mechanism, has effectively controlled the volume of whole instrument.
(6) full-automatic reaction instrument of the present invention is provided with and connects liquid bath, and the waste liquid splashed in cleaning process can fall into and connect liquid bath, avoids polluting.
(7) the constant temperature oven parts of full-automatic reaction instrument of the present invention are provided with air circulation device and temperature inductor, can well keep homogeneity, stability and the accuracy of temperature.
(8) oscillating mechanism of full-automatic reaction instrument of the present invention is simple for structure, high efficiency, and easy-abrasion part is easily replaced, and maintenance maintenance is convenient.
(9) left cover of the upper casing of full-automatic reaction instrument of the present invention is provided with lock buckling part, this lock buckling part is simple for structure, easy to use, can left cover is locked, in guaranteeing that hand or other positions can't the emperipolesis spaces, and article can not fallen in space, prevent from causing human injury and device damage.
The accompanying drawing explanation
Fig. 1 is the perspective view of full-automatic reaction instrument of the present invention while observing from upper right side;
Fig. 2 is perspective exploded view when in Fig. 1, full-automatic reaction instrument is observed from lower right;
Fig. 3 is perspective view when about the upper case member in Fig. 2 is observed from upper right side, lid is opened;
Fig. 4 is upper case member in Fig. 2 perspective view during from beneath;
Perspective view is amplified in the part that Fig. 5 is A place in Fig. 3;
Fig. 6 is lower case member in Fig. 2 and the rear plate member perspective view while observing from upper right side;
Fig. 7 is the perspective view of the rear plate member in Fig. 6 while observing from rear;
Fig. 8 is that the full-automatic reaction instrument in Fig. 2 removes after case member the perspective view while observing from upper right side;
Fig. 9 is the perspective view after Fig. 8 removes rear section;
The perspective exploded view that Figure 10 is Fig. 9;
The perspective view that Figure 11 is the article carrying platform in Figure 10;
Figure 12 is article carrying platform in Figure 11 perspective view during from beneath;
Figure 13 is the perspective view of the constant temperature oven parts in Figure 10 while observing from right back;
Figure 14 is that the constant temperature oven parts in Figure 13 remove after upper cover the perspective view while observing from top;
The perspective view that Figure 15 is the oscillating mechanism in Figure 10;
Perspective view when Figure 16 is connecing liquid bath and observe from top in Figure 10;
The perspective exploded view that Figure 17 is the translation mechanism in Figure 10;
Figure 18 is the perspective view after Fig. 8 removes front part;
The perspective exploded view that Figure 19 is the electric unit in Figure 18;
The perspective exploded view that Figure 20 is the wiper mechanism in Figure 18;
The detergent line schematic diagram that Figure 21 is full-automatic reaction instrument of the present invention;
The perspective exploded view that Figure 22 is the jacking gear in Figure 20.
The Reference numeral of above-mentioned accompanying drawing is as follows:
Translation mechanism 1,
Translation track segment 11, translation guide rail 11-1, translation slide block 11-2, left side block 11-3, right side block 11-4, riser 11-4-1, horizontal base plate 11-4-2, base 11-4-3,
Translation screw mandrel parts 13, translation screw mandrel 13-1, translation feed screw nut 13-2, translation holder 13-3, translation screw mandrel bearing 13-4,
Translation motor parts 14, translation motor 14-1, translation motor seat 14-2, motor hole 14-2-1
Objective table 21, objective table main body 21-1, stopper slot 21-1-1, waste liquid tank 21-1-2, diversion trench 21-1-3, objective table slide block 21-2, left side objective table slide block 21-2-1, right side objective table slide block 21-2-2,
Rinse bath 22,
Constant temperature oven parts 3,
Constant temperature oven 31, constant temperature oven shell 31-1, fan installation portion 31-1-1, push-rod hole 31-1-2, constant temperature oven inner bag 31-2, heating cabinet 31-2-1, left plate 31-2-2, right plate 31-2-3, crossbeam 31-2-4, constant temperature oven fan 31-3, constant temperature oven junction block 31-4, constant temperature oven upper cover 31-5
Constant temperature oven base 32, seat board 32-1, left front leg 32-2, right front leg 32-3, left back leg 32-4, right back leg 32-5,
Translation optoelectronic switch 34, translation limit on the left switch 34-1, translation origin switch 34-2, translation limit on the right-right-hand limit switch 34-3,
Connect liquid bath 5, strip hole 51, flanging 52,
Wiper mechanism 6,
Jacking gear 62,
Framework 62-1, framework front side board 62-1-1, framework back side panel 62-1-2, frame head plate 62-1-3, chassis base 62-1-4,
Riser guide parts 62-2, riser guide 62-2-1, lifting slider 62-2-2, lifter plate 62-2-3,
Elevating screw parts 62-3, elevating screw 62-3-1, elevating screw nut 62-3-2, lifting holder 62-3-3, elevating screw bearing 62-3-4,
Lifting motor 62-4,
Lifting driving member 62-5, lifting synchronous pulley 62-5-1, lifting Timing Belt 62-5-2,
Crane 62-6, crane substrate 62-6-1, crane crossbeam 62-6-2, hook portion 62-6-3,
Lifting sensing chip 62-7,
Lifting optoelectronic switch 62-8, lifting limes superiors switch 62-8-1, lifting origin switch 62-8-2, lifting smallest limit switch 62-8-3,
Electric unit 7, power supply 71, programmable logic controller (PLC) 72, circuit board 73,
Case member 8,
Touch-screen parts 85, touch-screen 85-1, touch-screen installing plate 85-2, touch screen circuitry plate 85-3,
Embodiment
In the specific embodiment of the present invention, to the orientation of each parts and the description of mutual relationship, be according to carrying out under the full-automatic reaction instrument horizontal positioned state shown in Fig. 1.
(embodiment 1)
See Fig. 2 and Fig. 8, the full-automatic reaction instrument of the present embodiment comprises translation mechanism 1, article carrying platform 2, constant temperature oven parts 3, oscillating mechanism 4, connects liquid bath 5, wiper mechanism 6, electric unit 7, case member 8, rear plate member 9 and base plate 100.Base plate 100 is a horizontally disposed rectangular slab.
See Figure 17, translation mechanism 1 comprises translation track segment 11, translation base plate 12, translation screw mandrel parts 13, translation motor parts 14 and translation driving member 15.
Translation track segment 11 comprises translation guide rail 11-1, translation slide block 11-2, left side block 11-3 and right side block 11-4.Translation guide rail 11-1 left and right, to being horizontally disposed with, is fixed on base plate 100 from top by screw, and is positioned at the front portion of base plate 100.Translation slide block 11-2 has 2, and it is upper that the first from left right side is arranged on translation guide rail 11-1, can horizontally slip along translation guide rail 11-1.Left side block 11-3 is fixed by screws on base plate 100, and the left end of adjacent translation guide rail 11-1.Right side block 11-4 is a corner bracket, comprises riser 11-4-1, horizontal base plate 11-4-2 and base 11-4-3, and horizontal base plate 11-4-2 is connected with the top of riser 11-4-1 by its left part, and base 11-4-3 is connected with the bottom of riser 11-4-1 by its left part.Right side block 11-4 is fixed by screws on base plate 100 by its base 11-4-3, and the right-hand member of adjacent translation guide rail 11-1.
The right part of translation base plate 12 is fixedly connected on by screw from top the translation slide block 11-2 that is positioned at right side, and the middle part of translation base plate 12 is fixedly connected on the translation slide block 11-2 that is positioned at left side by screw from top.
Translation screw mandrel parts 13 comprise translation screw mandrel 13-1, translation feed screw nut 13-2, translation holder 13-3, peaceful silk shifting rod bearing 13-4.Translation holder 13-3 is enclosed within on translation feed screw nut 13-2, and translation feed screw nut 13-2 is fixed by screws on translation holder 13-3.Translation holder 13-3 is fixed on the middle part of translation base plate 12 from top by screw.Have through hole on the riser 11-4-1 of the right side block 11-4 of translation track segment 11, translation screw mandrel bearing 13-4 is fixed on the through hole of riser 11-4-1.Translation screw mandrel 13-1 left and right, to being horizontally disposed with, through translation feed screw nut 13-2, and is meshed with translation feed screw nut 13-2.The right-hand member head of translation screw mandrel 13-1, through translation screw mandrel bearing 13-4, stretch out to the right.
Translation motor parts 14 comprise translation motor 14-1 and translation motor cabinet 14-2.Offer the motor hole 14-2-1 that left and right connects on translation motor seat 14-2.Translation motor seat 14-2 is fixed on base plate 100 from top by screw, and is positioned at the rear of the right side block 11-4 of translation track segment 11.Translation motor 14-1 is fixed on translation motor seat 14-2 from left by screw, and the right-hand member head of the motor shaft of translation motor 14-1 through the motor hole 14-2-1 on translation motor seat 14-2, stretches out to the right from left to right.
See Figure 10 and Figure 17, connect liquid bath 5 for top and right-hand all unlimited box bodys, connect on the base plate of liquid bath 5 and offer along left and right to the strip hole 51 arranged, the right-hand member in strip hole 51 communicates with the right side boundary of the base plate that connects liquid bath 5, the width in strip hole 51 equals the width of translation guide rail 11-1, and the edge of 51 edge, strip hole and the base plate that connects liquid bath 5 is equipped with the flanging 52 that the direction that is connected makes progress.Connect liquid bath 5 and be fixed on base plate 100 from top by screw, and be positioned at the left front section of base plate 100, left section of translation guide rail 11-1 is positioned at the strip hole 51 that connects liquid bath 5, and the base plate that connects liquid bath 5 is positioned at the below of translation base plate 12 and left side block 11-3.
See Figure 11 and Figure 12, article carrying platform 2 comprises objective table 21, rinse bath 22,24,4 guide pin bushings of 23,2 guide rods of stage carrier assembly 25,2 stage clips 26, sealing gasket 27, pressing plate 28 and baffle plates 29.Rinse bath 22 opening upwards.
Objective table 21 is the integrated through injection molding part, comprises objective table main body 21-1 and 2 objective table slide block 21-2.The upper surface of objective table main body 21-1 offers 2 stopper slot 21-1-1 and 1 waste liquid tank 21-1-2.Stopper slot 21-1-1 is shaped as rectangle, with the shape of protein film chip, is complementary, and 2 stopper slot 21-1-1 mono-the first from left right sides are arranged side by side.Waste liquid tank 21-1-2 is shaped as strip, and front and back, to setting, are positioned at the right side of right side stopper slot 21-1-1.2 stopper slot 21-1-1 and the bottom of waste liquid tank 21-1-2 offer 7 left and right to arrange by stopper slot 21-1-1 and diversion trench 21-1-3 together with waste liquid tank 21-1-2 is interconnected.All one in front and one in back offer 2 left and right to the circular hole connected on 2 objective table slide block 21-2.2 objective table slide block 21-2 are divided into left side objective table slide block 21-2-1 and right side objective table slide block 21-2-2, left side objective table slide block 21-2-1 is connected to objective table main body 21-1 from below, and be positioned at the left side central portion of objective table main body 21-1, right side objective table slide block 21-2-2 is connected to objective table main body 21-1 from below, and is positioned at the right side central of objective table main body 21-1.Baffle plate 29 vertically arranges, by screw from the right-hand right flank that is fixed on objective table main body 21-1.
Stage carrier assembly 23 comprises fore-stock 23-1, after-poppet 23-2, left side tie-beam 23-3, middle part tie-beam 23-4 and right side tie-beam 23-5.Fore-stock 23-1 is identical with the shape of after-poppet 23-2, includes foot rest and crossbeam separately, and crossbeam is connected to the top of foot rest by its left end head.Fore-stock 23-1 and after-poppet 23-2 one in front and one in back are symmetrical arranged.Left side tie-beam 23-3, middle part tie-beam 23-4 and right side tie-beam 23-5 all before and after to setting, and according to order from left to right, be sequentially arranged between the crossbeam of the crossbeam of fore-stock 23-1 and after-poppet 23-2.The front end of left side tie-beam 23-3, middle part tie-beam 23-4 and right side tie-beam 23-5 all is fixedly connected on the crossbeam of fore-stock 23-1 by screw, and the rear end of left side tie-beam 23-3, middle part tie-beam 23-4 and right side tie-beam 23-5 all is fixedly connected on the crossbeam of after-poppet 23-2 by screw.
Rinse bath 22 is fixed by screws on fore-stock 23-1, the after-poppet 23-2 and left side tie-beam 23-3 of stage carrier assembly 23, and is positioned at the upper right side of stage carrier assembly 23.Sealing gasket 27 and pressing plate 28 all vertically arrange, the right flank of the adjacent rinse bath 22 of sealing gasket 27, and pressing plate 28 is positioned at the right-hand of sealing gasket 27, and pressing plate 28 is fixed by screws in rinse bath 22 from right-hand, thereby sealing gasket 27 is fixed on the right flank of rinse bath 22.Fore-stock 23-1 and after-poppet 23-2 are all through sealing gasket 27 and pressing plate 28.
4 guide pin bushings 25 are separately fixed in 2 circular holes of 2 circular holes of left side objective table slide block 21-2-1 and right side objective table slide block 21-2-2.2 guide rods 24 are all along left and right to being horizontally disposed with, and respectively from left to right successively through guide pin bushing 25 and right side tie-beam 23-5 on the guide pin bushing 25 on left side tie-beam 23-3, sealing gasket 27, pressing plate 28, left side objective table slide block 21-2-1, middle part tie-beam 23-4, corresponding stage clip 26, right side objective table slide block 21-2-2, and with left side tie-beam 23-3, middle part tie-beam 23-4 and right side tie-beam 23-5 wringing fit.The left end head of 2 stage clips 26 contacts with middle part tie-beam 23-4, and the right-hand member head of 2 stage clips 26 contacts with right side objective table slide block 21-2-2.Objective table 21 is slidably connected on guide rod 24 by guide pin bushing 25, and stage clip 26 applies direction power to the right to objective table 21 all the time by self elastic force, thus make objective table 21 can with respect to stage carrier assembly 23 carry out left and right to elastic movement.
See Figure 10, article carrying platform 2 is fixed on translation base plate 12 from top by screw by its stage carrier assembly 23, and is positioned at the left part of translation base plate 12.
Translation motor 14-1 is by the transmission of translation synchronous pulley 15-1 and translation Timing Belt 15-2, drive translation screw mandrel 13-1 to be rotated, translation base plate 12 under the effect of translation screw mandrel parts 13 and translation track segment 11 along left and right to being moved, thereby make article carrying platform 2 together along left and right to doing translation motion.
See Figure 10, Figure 13 and Figure 14, constant temperature oven parts 3 comprise constant temperature oven 31, constant temperature oven base 32, temperature inductor 33 and translation optoelectronic switch 34.
Constant temperature oven 31 comprises constant temperature oven shell 31-1, constant temperature oven inner bag 31-2, constant temperature oven fan 31-3, constant temperature oven junction block 31-4 and constant temperature oven upper cover 31-5.Constant temperature oven shell 31-1 is all unlimited box bodys of top and left, and the front and rear of the right plate of constant temperature oven shell 31-1 is equipped with the fan installation portion 31-1-1 of projection to the right.Constant temperature oven inner bag 31-2 comprises heating cabinet 31-2-1, left plate 31-2-2, right plate 31-2-3 and crossbeam 31-2-4.The inner chamber left and right of heating cabinet 31-2-1, to perforation, is provided with heating arrangement between the inner and outer wall of heating cabinet 31-2-1.The central position of left plate 31-2-2 and right plate 31-2-3 all offers the through hole identical with the inner chamber size of heating cabinet 31-2-1.Left plate 31-2-2 vertically arranges, and is fixed on heating cabinet 31-2-1 by the edge of its through hole upper, and is positioned at the left side of heating cabinet 31-2-1, and the through hole on left plate 31-2-2 is the opening of constant temperature oven 31.Right plate 31-2-3 vertically arranges, and is fixed on heating cabinet 31-2-1 by the edge of its through hole upper, and is positioned at the right side of heating cabinet 31-2-1.Before and after crossbeam 31-2-4, to being horizontally disposed with, its front end is connected to the forward edge place of the through hole of right plate 31-2-3, and its rear end is connected to the posterior edges place of the through hole of right plate 31-2-3, thereby the through hole of right plate 31-2-3 is divided into to upper and lower two parts.Constant temperature oven inner bag 31-2 is positioned at constant temperature oven shell 31-1, and the left plate 31-2-2 of constant temperature oven inner bag 31-2 is positioned at the left side opening part of incubator shell 31-1, the fan installation portion 31-1-1 of the adjacent constant temperature oven shell of the right plate 31-2-3 31-1 of constant temperature oven inner bag 31-2.Constant temperature oven fan 31-3 has 2, is fixed by screws in respectively in the corresponding fan installation portion 31-1-1 of constant temperature oven shell 31-1.2 constant temperature oven fan 31-3 are horizontally disposed with, and are positioned at the right side of the crossbeam 31-2-4 of constant temperature oven inner bag 31-2, and air-out direction is downward.Junction block 31-4 is fixed on the back side panel of constant temperature oven shell 31-1.The airtight upper opening place that is fixed on constant temperature oven shell 31-1 of constant temperature oven upper cover 31-5.
Constant temperature oven base 32 is the steel integral piece, comprises seat board 32-1, left front leg 32-2, right front leg 32-3, left back leg 32-4 and right back leg 32-5.Left front leg 32-2, right front leg 32-3, left back leg 32-4 and right back leg 32-5 are connected to seat board 32-1 from below by its upper end, and lay respectively at left side front end, right side front end, rear end, left side and the rear end, right side of seat board 32-1.Constant temperature oven base 32 is fixed by screws in the bottom of constant temperature oven shell 31-1 by its seat board 32-1.
The probe of temperature inductor 33 is through the right plate of constant temperature oven shell 31-1, stretches in the inner chamber of heating cabinet 31-2-1 of constant temperature oven inner bag 31-2, and temperature inductor 33 is fixed on the right plate of constant temperature oven shell 31-1 by its pedestal.
Translation optoelectronic switch 34 has 3, is divided into translation limit on the left switch 34-1, translation origin switch 34-2 and translation limit on the right-right-hand limit switch 34-3.Translation limit on the left switch 34-1 is fixed on the left front leg 32-2 of constant temperature oven base 32 from rear by screw.Translation origin switch 34-2 and translation limit on the right-right-hand limit switch 34-3 all are fixed on the right front leg 32-3 of constant temperature oven base 32 from rear by screw, and translation origin switch 34-2 is positioned at the left side of translation limit on the right-right-hand limit switch 34-3.
See Figure 17, translation mechanism 1 also comprises translation sensing chip 16.Translation sensing chip 16 is fixed on translation base plate 12 from top by screw, and is positioned at the right front portion of translation base plate 12, and the front side of translation sensing chip 16 is provided with protuberance, and its protuberance is positioned at outside translation base plate 12.Translation sensing chip 16 on translation base plate 12 is to match with translation optoelectronic switch 34, the electrical equipment of feedback translation position signalling.
See Figure 10, constant temperature oven parts 3 are fixed on base plate 100 from top by screw by the left front leg 32-2 of its constant temperature oven base 32, right front leg 32-3, left back leg 32-4 and right back leg 32-5, and are positioned at top, the article carrying platform 2 of translation guide rail 11-1 and connect the right side of liquid bath 5.
See Figure 15, oscillating mechanism 4 comprises vibration motor 41, vibration motor installing plate 42, vibration support 43, eccentric wheel 44, vibration bearing 45, vibration cam 46, vibration connecting rod 47, vibration push rod 48 and lining 49.Vibration push rod 48 is the oscillating member 48 of oscillating mechanism 4.
Vibration support 43 is the steel integral piece, comprise vibration stent substrate 43-1 and vibration rack side plate 43-2, vibration rack side plate 43-2, along front and back to vertical setting, is connected to the left end of vibration stent substrate 43-1 from top, on vibration rack side plate 43-2, offer left and right to the circular hole connected.Lining 49 passes the circular hole on vibration rack side plate 43-2, and is fixed by screws on vibration rack side plate 43-2.Vibration motor installing plate 42 is along left and right to vertical setting, and vibration motor installing plate 42 is fixed on vibration stent substrate 43-1 from top by screw, and is positioned at vibration stent substrate 43-1 rear side, offers front and back on vibration motor installing plate 42 to the hole connected.Vibration motor 41 is fixed by screws on vibration motor installing plate 42, and is positioned at the rear of vibration motor installing plate 42.The motor shaft of vibration motor 41, through the hole on vibration motor installing plate 42, stretches out forward.Eccentric wheel 44 is fixed on the front end of motor shaft of vibration motor 41, and before and after the front side of eccentric wheel 44 is provided with, to horizontally disposed axle, the front end of axle is provided with screw thread.Vibration bearing 45 is enclosed within on the axle of eccentric wheel 44, and nut screws on the axle of eccentric wheel 44 from the place ahead, thereby carries out axial spacing to vibration bearing 45.Vibration cam 46 comprises round plate 46-1 and is arranged on the protuberance 46-2 in round plate 46-1 left side, and the central authorities of round plate offer circular hole, vibration cam 46 by the circle hole sleeve of its round plate 46-1 on vibration bearing 45, and with the outer ring wringing fit of vibration bearing 45.Vibration connecting rod 47 is along the left and right horizontal setting, and the right-hand member of vibration connecting rod 47 is hinged with the left end of the protuberance 46-2 of vibration cam 46.Vibration push rod 48 is along the left and right horizontal setting, and the right-hand member of vibration push rod 48 is fixedly connected on the left end of vibration connecting rod 47 by fixed pin, and vibration push rod 48 stretches out to the right through lining 49.
See Fig. 9 and Figure 10, oscillating mechanism 4 is fixed on the right side block 11-4 of translation track segment 11 from top by screw by the vibration stent substrate 43-1 of its vibration support 43, and is positioned at the top of right side block 11-4.The right plate of the constant temperature oven shell 31-1 of the adjacent constant temperature oven 31 of vibration rack side plate 43-2 of oscillating mechanism 4.The position between 2 fan installation portion 31-1-1 of the right plate of constant temperature oven shell 31-1 offers push-rod hole 31-1-2, and lining 49 is through the push-rod hole 31-1-2 of constant temperature oven shell 31-1, and vibration push rod 48 stretches in the constant temperature oven inner bag 31-2 of constant temperature oven 31.
See Figure 20, wiper mechanism 6 comprises cleaning head 61, jacking gear 62 and pump assembly 63.Pump assembly 63 is that the parts of feed liquor, imbibition power are provided for cleaning head 61.
See Figure 22, what cleaning head 61 adopted is that Chinese patent literature CN101332459A(application number is: the cleaning head of a kind of porous plate of 200710042657.4) announcing.Cleaning head 61 comprises cleaning head main body 61-1, water injection pipe 61-2, suction hose 61-3, water filling interface 61-4, water outlet mouthpiece 61-5.Cleaning head main body 61-1 is strip, along front and back to being horizontally disposed with.Water filling interface 61-4, water outlet mouthpiece 61-5 all are arranged on the top of cleaning head main body 61-1.Water injection pipe 61-2 has 8, vertically arranges, along front and back to being arranged in a row.Each root water injection pipe 61-2 is fixedly connected on the bottom of cleaning head main body 61-1 by its top, each root water injection pipe 61-2 is connected with water filling interface 61-4.Suction hose 61-3 has 8, vertically arranges, along front and back to being arranged in a row.Each root suction hose 61-3 is fixedly connected on the bottom of cleaning head main body 61-1 by its top, and is positioned at separately the right side of corresponding water injection pipe 61-2, and each root suction hose 61-3 is connected with water outlet mouthpiece 61-5.The length of water injection pipe 61-2 is less than the length of suction hose 61-3, and the caliber of water injection pipe 61-2 is less than the caliber of suction hose 61-3.Cleaning head 61 also comprises cleaning head support 61-6.Cleaning head 61 is fixed by screws on cleaning head support 61-6 by its cleaning head main body 61-1.The front-end and back-end on the right side of cleaning head support 61-6 are provided with hook 61-6-1.
Jacking gear 62 comprises framework 62-1, riser guide parts 62-2, elevating screw parts 62-3, lifting motor 62-4, lifting driving member 62-5, lifting sensing chip 62-7 and lifting optoelectronic switch 62-8.
Framework 62-1 comprises framework front side board 62-1-1, framework back side panel 62-1-2, frame head plate 62-1-3, chassis base 62-1-4.The front end of frame head plate 62-1-3 is fixedly connected with the upper end of framework front side board 62-1-1, the rear end of frame head plate 62-1-3 is fixedly connected with the upper end of framework back side panel 62-1-2, the front end of chassis base 62-1-4 is fixedly connected with the lower end of framework front side board 62-1-1, and the rear end of chassis base 62-1-4 is fixedly connected with the lower end of framework back side panel 62-1-2.The right part of chassis base 62-1-4 offers the screw mandrel mounting hole of up/down perforation.
Riser guide parts 62-2 comprises riser guide 62-2-1, lifting slider 62-2-2 and lifter plate 62-2-3.Riser guide 62-2-1 upward and downward is horizontally disposed with, and is fixed on framework back side panel 62-1-2 from the place ahead by screw, and is positioned at the right part of framework back side panel 62-1-2.Lifting slider 62-2-2 is arranged on riser guide 62-2-1, can slide up and down along riser guide 62-2-1.Lifter plate 62-2-3 is fixed on lifting slider 62-2-2 from the place ahead by screw.
Elevating screw parts 62-3 comprises elevating screw 62-3-1, elevating screw nut 62-3-2, lifting holder 62-3-3, elevating screw bearing 62-3-4.It is upper that lifting holder 62-3-3 is enclosed within elevating screw nut 62-3-2, and elevating screw nut 62-3-2 is fixed by screws on lifting holder 62-3-3.Lifting holder 62-3-3 is fixed on lifter plate 62-2-3 from the place ahead by screw.The right part of frame head plate 62-1-3 offers the dead eye of up/down perforation, and elevating screw bearing 62-3-4 is fixed on this dead eye place.Elevating screw 62-3-1 vertically arranges, and through elevating screw nut 62-3-2, and is meshed with elevating screw nut 62-3-2.The upper end of elevating screw 62-3-1, through elevating screw bearing 62-3-4, protrude upward.
The left part of frame head plate 62-1-3 offers the motor hole of up/down perforation.Lifting motor 62-4 is fixed on frame head plate 62-1-3 left part from below by screw.The upper end of the motor shaft of lifting motor 62-4 through the motor hole of frame head plate 62-1-3, protrudes upward from bottom to top.
Lifting driving member 62-5 comprises lifting synchronous pulley 62-5-1 and lifting Timing Belt 62-5-2.Lifting synchronous pulley 62-5-1 has 2, wherein 1 lifting synchronous pulley 62-5-1 is enclosed within on the upper end of elevating screw 62-3-1, and 62-3-1 is fixedly connected with elevating screw, another 1 lifting synchronous pulley 62-5-1 is enclosed within on the motor shaft of lifting motor 62-4, and is fixedly connected with the motor shaft of lifting motor 62-4.It is upper that lifting Timing Belt 62-5-2 is enclosed within 2 lifting synchronous pulley 62-5-1, and be meshed with lifting synchronous pulley 62-5-1.
Crane 62-6 comprises crane substrate 62-6-1 and crane crossbeam 62-6-2.Before and after crane substrate 62-6-1, to vertical setting, before and after crane crossbeam 62-6-2, to being horizontally disposed with, crane crossbeam 62-6-2 is connected to the top of crane substrate 62-6-1 by its rear end.Front end and the middle part of crane crossbeam 62-6-2 are equipped with hook portion 62-6-3, the hook 61-6-1 of cleaning head support 61-6 is stuck in the hook portion 62-6-3 of crane crossbeam 62-6-2, thereby make cleaning head 61 be fixed on the crane crossbeam 62-6-2 of crane 62-6, and be positioned at the left side of crane crossbeam 62-6-2.Crane 62-6 by its crane substrate 62-6-1 by screw from the right-hand right side that is fixed on lifting holder 62-3-3.
Lifting motor 62-4 is by the transmission of lifting synchronous pulley 62-5-1 and lifting Timing Belt 62-5-2, drive elevating screw 62-3-1 to be rotated, lifting holder 62-3-3 is moved along upward and downward under the effect of elevating screw nut 62-3-2 and riser guide parts 62-2, thereby makes cleaning head 61 and crane 62-6 together move up and down along upward and downward.
It is upper that lifting sensing chip 62-7 is fixed by screws in lifting holder 62-3-3, and be positioned at the upper left quarter of the front side of lifting holder 62-3-3.Lifting optoelectronic switch 62-8 has 3, all by screw, from the place ahead, is fixed on framework front side board 62-1-1, and is positioned at the right side boundary place of framework front side board 62-1-1.3 lifting optoelectronic switch 62-8 arrange according to upward and downward, are followed successively by from top to bottom lifting limes superiors switch 62-8-1, lifting origin switch 62-8-2 and lifting smallest limit switch 62-8-3.Lifting sensing chip 62-7 matches with lifting optoelectronic switch 62-8, the electrical equipment of feedback lifting position signal.
See Figure 20, pump assembly 63 comprises liquid charge pump 63-1, impact damper 63-2, solenoid valve 63-3, suction pumps 63-4, shock-resistant member 63-5, bumper support 63-6 and pump groove 63-7.Pump groove 63-7 opening upwards, be positioned at the left back section of base plate 100.Suction pumps 63-4 is air pump, suction pumps 63-4 is fixed on shock-resistant member 63-5 from top by screw, suction pumps 63-4 and shock-resistant member 63-5 all are positioned at pump groove 63-7, shock-resistant member 63-5 passes pump groove 63-7 by screw and is fixed on base plate 100 from top, thereby pump groove 63-7 is fixed on base plate 100.Liquid charge pump 63-1 is hydraulic pump, and liquid charge pump 63-1 is positioned at the right side of pump groove 63-7, suction pumps 63-4, and is fixed by screws on the right plate of pump groove 63-7.The main body of bumper support 63-6 is horizontally disposed with, and its right part bends downwards, and the left part that bumper support 63-6 passes frame head plate 62-1-3 by its right lateral bend folding part by screw is fixed on lifting motor 62-4.Impact damper 63-2 is fixed on the left part of bumper support 63-6 from below by screw, solenoid valve 63-3 is fixed on the middle part of bumper support 63-6 from below by screw.
See Figure 18 and Figure 19, electric unit 7 comprises power supply 71, programmable logic controller (PLC) 72 and circuit board 73.Circuit board 73 front and back, to vertical setting, are fixed by screws on base plate 100, and are positioned at the right side of jacking gear 62.Power supply 71 left and right, to vertical setting, are fixed by screws on base plate 100, and are positioned at the right back of circuit board 73.Programmable logic controller (PLC) 72 is fixed by screws on base plate 100, and is positioned at the place ahead of power supply 71.
See Fig. 6 and Fig. 7, rear plate member 9 comprises rear plate 91, Switching Power Supply button box 92, liquid inlet joint 93, imbibition joint 94, negative pressure joint 95.Rear plate 91 vertically arranges, and Switching Power Supply button box 92, liquid inlet joint 93, imbibition joint 94 and negative pressure joint 95 be all through rear plate 91, and is fixed on rear plate 91.Switching Power Supply button box 92 comprises internal electric source joint 92-1, external power source joint 92-2, fuse base 92-3 and switch 92-4.Internal electric source joint 92-1 is arranged on the front side of Switching Power Supply button box 92, with power supply 71, is electrically connected to.Switch 92-4, fuse base 92-3, external power source joint 92-2 are successively set on the rear side of Switching Power Supply button box 92 according to direction from top to bottom.
See Figure 21, the full-automatic reaction instrument of the present embodiment also comprises bottle for handling liquid toilet or cosmetic substance 101, waste liquid bottle 102 and surge flask 103.In bottle for handling liquid toilet or cosmetic substance 101, washing lotion is housed, stretches in the washing lotion of bottle for handling liquid toilet or cosmetic substance 101 with the airtight flexible pipe be connected in liquid inlet joint 93 rear ends.Liquid inlet joint 93 front ends are connected with the inlet of liquid charge pump 63-1 is airtight by flexible pipe.The liquid outlet of liquid charge pump 63-1 is connected with the inlet of impact damper 63-2 is airtight by flexible pipe.The liquid outlet of impact damper 63-2 is by airtight being connected of water filling interface 61-4 of flexible pipe with cleaning head 61 through solenoid valve 63-3.The water outlet mouthpiece 61-5 of cleaning head 61 is connected with the front end of imbibition joint 94 is airtight by flexible pipe.The rear end of imbibition joint 94 is connected with waste liquid bottle 102 is airtight by flexible pipe.Waste liquid bottle 102 is connected with surge flask 103 is airtight by flexible pipe.Surge flask 103 is connected with the rear end of negative pressure joint 95 is airtight by flexible pipe, and the front end of negative pressure joint 95 is connected with the air intake opening of suction pumps 63-4 is airtight by flexible pipe.
See Fig. 2 to Fig. 4, case member 8 comprises upper casing 81, left cover 82, right cover 83, power supply fan 84, touch-screen parts 85, lower casing 87 and feet 88.Upper casing 81, left cover 82, right cover 83, power supply fan 84 and touch-screen parts 85 are upper case member, and lower casing 87 and feet 88 are lower case member.
See Fig. 1, Fig. 3 and Fig. 4, upper casing 81 is the downward housing of lumen openings, the left front section of upper casing 81 offers gathering hole 81-1, and the right part of upper casing 81 offers touch-screen installing port 81-2, and the right part of the back side panel of upper casing 81 offers 2 thermovent 81-3 of the right setting of a first from left.The material of left cover 82 and right cover 83 is transparent plastic.Left cover 82 is rotatably connected on upper casing 81 by its rear end, and is positioned at the top of upper casing 81 left parts.Right cover 83 is rotatably connected on upper casing 81 by its rear end, and is positioned at the top of upper casing 81 right parts.Power supply fan 84 has 2, all is fixed by screws in the thermovent 81-3 place of corresponding upper casing 81, and air-out direction backward.Touch-screen parts 85 comprise touch-screen 85-1, touch-screen installing plate 85-2 and touch screen circuitry plate 85-3.Touch-screen 85-1 is fixed on touch-screen installing plate 85-2 from top by screw, and touch screen circuitry plate 85-3 is fixed on touch-screen installing plate 85-2 from below by screw, and touch-screen 85-1 is electrically connected to touch screen circuitry plate 85-3.Touch-screen installing plate 85-2 is fixed on upper casing 81 from below by screw, and touch-screen 85-1 is arranged in touch-screen installing port 81-2.
See Fig. 2 and Fig. 6, the housing that lower casing 87 makes progress for lumen openings, the left side of lower casing 87 and right side are equipped with the carrying attacker 87-1 of section concaved, and feet 88 has 4, all by screw, from below, be fixed on lower casing 87, and lay respectively at the left front section of lower casing 87, left back section, right front portion and right back section.Lower casing 87 is fixed on base plate 100 from below by screw.The shell rim shape of lower casing 87 and the shell rim shape of upper casing 81 are complementary, upper casing 81 by screw from top airtight being fixed on lower casing 87, the gathering hole 81-1 of upper casing 81 is positioned at the top that connects liquid bath 5, and rear plate member 9 is stuck between the back side panel of the back side panel of upper casing 81 and lower casing 87.
See Fig. 1, Fig. 3 and Fig. 5, the upper case member of case member 8 also comprises lock buckling part 86.Lock buckling part 86 comprises snap close 86-1, snap close pressing plate 86-2, snap close bearing 86-3 and snap close bearing axle 86-4.Snap close bearing 86-3 is fixed on upper casing 81, and is positioned at the left back section of upper casing 81, the left side of left cover 82.Snap close bearing axle 86-4 left and right, to being horizontally disposed with, is fixed on snap close bearing 86-3 by its left end.The left part of snap close 86-1 is provided with the buckle 86-1-1 that direction arranges downward vertically, and buckle 86-1-1 is provided with opening groove forward, and the position of this groove is corresponding with the position of snap close bearing axle 86-4.The left back section of left cover 82 offers the sagittal groove 82-1 that slides, and the place ahead of sliding groove 82-1 of left cover 82 is provided with the downward front side reference column 82-2 of direction, and the rear of sliding groove 82-1 of left cover 82 is provided with the downward rear side reference column 82-3 of direction.The front end of snap close pressing plate 86-2 is provided with front card interface 86-2-1, and the rear end of snap close pressing plate 86-2 is provided with rear card interface 86-2-2.Screw screws on snap close 86-1 through the groove 82-1 that slides of snap close pressing plate 86-2 and left cover 82 from the bottom up successively, thereby makes snap close 86-1 upwards to be slided in front and back along sliding groove 82-1.
When left cover 82 is positioned at closure state, sliding shackle 86-1 forward, until the front side reference column 82-2 of left cover 82 is connected in the front card interface 86-2-1 of snap close pressing plate 86-2, snap close bearing axle 86-4 is stuck in the groove of buckle 86-1-1 of snap close 86-1, thereby make snap close 86-1 in locking state, left cover 82 can't be opened.In the time of need to opening left cover 82, slide backward snap close 86-1, until the rear side reference column 82-3 of left cover 82 is connected in the rear card interface 86-2-2 of snap close pressing plate 86-2, snap close bearing axle 86-4 is positioned at kayser and buckles outside the groove of buckle 86-1-1 of 86-1, thereby make snap close 86-1 in opening, left cover 82 can be opened.
Power supply 71, programmable logic controller (PLC) 72 and circuit board 73 respectively with the translation motor 14-1 of translation mechanism 1, the heating cabinet 31-2-1 of constant temperature oven parts 3, constant temperature oven fan 31-3, temperature inductor 33, translation optoelectronic switch 34, the vibration motor 41 of oscillating mechanism 4, the lifting motor 62-4 of wiper mechanism 6, lifting optoelectronic switch 62-8, liquid charge pump 63-1, solenoid valve 63-3, suction pumps 63-4, the power supply fan 84 of case member 8, the touch screen circuitry plate 85-3 of touch-screen parts 85 is electrically connected to.Electric unit 7 is the parts that electric power are provided, controlled for translation mechanism 1, constant temperature oven parts 3, oscillating mechanism 4, wiper mechanism 6, and touch-screen parts 85 are signal input parts of electric unit 7.
The full-automatic reaction instrument of the present embodiment in use, first switches on power, and opens switch 92-4, starts right cover 83, uses touch-screen 85-1 to select corresponding working procedure.Cleaning head 61 now is in highest point, article carrying platform 2, in the rightmost side, is arranged in constant temperature oven 31, and article carrying platform 2 is sealed the case mouth of constant temperature oven 31 by its sealing gasket 27, the heating cabinet 31-2-1 of constant temperature oven 31 and constant temperature oven fan 31-3 start working, and make the temperature in constant temperature oven rise.The temperature of constant temperature oven 31 feeds back to the temperature controller of programmable logic controller (PLC) 72 by temperature inductor 33, this temperature controller, by controlling heating cabinet 31-2-1 and constant temperature oven fan 31-3, makes the temperature of constant temperature oven 31 remain at 37 degrees centigrade of left and right.When the temperature in constant temperature oven 31 reaches 37 degrees centigrade, the instrument prompting of sounding a buzzer, article carrying platform 2 moves to the limit on the left position left under the effect of translation mechanism 1, now by snap close 86-1 in opening, start left cover 82, will add the protein film chip of sample or the stopper slot 21-1-1 that ELISA Plate is put into objective table 21.Subsequently, the left cover 82 of closing, by snap close 86-1 in locking state, article carrying platform 2 moves right to the limit on the right-right-hand limit position, the case mouth sealing of constant temperature oven 31, the left end head of the vibration push rod 48 of oscillating mechanism 4 contacts with the baffle plate 29 of article carrying platform 2, and article carrying platform 2 now is in the vibration position.During vibration motor 41 setting in motion, vibration push rod 48 promotes objective table 21 and moves to high-frequency reciprocating along left and right, thereby makes protein film chip or ELISA Plate carry out the constant temperature oscillation reaction.After reaching the reaction time of program setting, vibration motor 41 stop motions, the cleaning head 61 of wiper mechanism 6 moves downward to the smallest limit position under the effect of jacking gear 62, the water injection pipe 61-2 of cleaning head 61 and suction hose 61-3 are positioned at the rinse bath 22 of article carrying platform 2, water injection pipe 61-2 water outlet, suction hose 61-3 water suction, thus self is cleaned.Subsequently, cleaning head 61 rises, and article carrying platform 2 is to left movement, and when cleaning head 61 is aimed at the 1st row of protein film chip or ELISA Plate, article carrying platform 2 is static, and article carrying platform 2 now is in cleaning positions, and cleaning head 61 descends, and corresponding reacting hole is cleaned.Then repeat above-mentioned steps, protein film chip or ELISA Plate are cleaned by row, after cleaning, in every row's reacting hole, all leave 1/3 cleaning fluid.Then article carrying platform 2 moves right to constant temperature oven 31, and vibration motor 41 setting in motions carry out oscillation cleaning (above oscillation cleaning can repeatedly) to protein film chip or ELISA Plate.After last oscillation cleaning, cleaning fluid is blotted, and article carrying platform 2 moves to the limit on the left position left, now by snap close 86-1 in opening, start left cover 82, add corresponding enzyme in reacting hole.Then the left cover 82 of closing, by snap close 86-1, in locking state, article carrying platform 2 moves right to the limit on the right-right-hand limit position and carries out the constant temperature oscillation reaction.After reaching the reaction time of program setting, again enter oscillation cleaning process (above oscillation cleaning must repeatedly).After last oscillation cleaning, cleaning fluid is blotted, article carrying platform 2 moves to the limit on the left position left, the instrument prompting of sounding a buzzer, now by snap close 86-1 in opening, start left cover 82, protein film chip or ELISA Plate are taken out, " completing confirmation " button on point touching plate 85-1, the reaction instrument automatically resets, and carries out the preparation of operation next time.The reaction instrument, in the oscillation cleaning process, can, according to the setting of program, sop up the waste liquid in the waste liquid tank 21-1-2 of objective table 21 automatically.
Claims (9)
1. a full-automatic reaction instrument, is characterized in that: comprise translation mechanism (1), article carrying platform (2), constant temperature oven parts (3), oscillating mechanism (4), wiper mechanism (6), electric unit (7), case member (8) and base plate (100);
Translation mechanism (1) is arranged on the front portion of base plate (100) from top; Article carrying platform (2) comprises objective table (21) and stage carrier assembly (23), and objective table (21) is connected to along left and right to Elastic Sliding on stage carrier assembly (23); The stage carrier assembly (23) of article carrying platform (2) by about translation mechanism (1) to being slidably connected on base plate (100); Constant temperature oven parts (3) comprise constant temperature oven (31) and constant temperature oven base (32), constant temperature oven (31) opening left, be fixed on constant temperature oven base (32), constant temperature oven parts (3) are fixed on base plate (100) from top by its constant temperature oven base (32), and are positioned at the top of translation mechanism (1), the right side of article carrying platform (2); Oscillating mechanism (4) is arranged on the right side of constant temperature oven (31), and the oscillating member (48) of oscillating mechanism (4) stretches in constant temperature oven (31); Wiper mechanism (6) comprises cleaning head (61), jacking gear (62) and pump assembly (63); It is upper that cleaning head (61) is slidably connected at base plate (100) by jacking gear (62) upward and downward, and be positioned at the middle front part of base plate (100); Pump assembly (63) is that the parts of feed liquor, imbibition power are provided for cleaning head (61); Electric unit (7) is arranged on the right back section of base plate (100); Case member (8) comprises upper casing (81), touch-screen parts (85) and lower casing (87); The left front section of upper casing (81) offers gathering hole (81-1), and the right part of upper casing (81) offers touch-screen installing port (81-2), and touch-screen parts (85) are arranged on touch-screen installing port (81-2) and locate; Lower casing (87) is fixed on base plate (100) from below; Upper casing (81) is airtight being fixed on lower casing (87) from top;
Electric unit (7) is the parts that electric power are provided, controlled for translation mechanism (1), constant temperature oven parts (3), oscillating mechanism (4), wiper mechanism (6), and touch-screen parts (85) are the signal input parts of electric unit (7);
Article carrying platform in use (2) can be in left side cleaning positions or the vibration position in right side; Article carrying platform (2) is when cleaning positions, and article carrying platform (2) is positioned at the below of gathering hole (81-1), and cleaning head (61) is positioned at the top of objective table (21); Article carrying platform (2) is when the vibration position, and article carrying platform (2) is arranged in constant temperature oven (31), and oscillating member (48) contacts with objective table (21);
Described cleaning head (61) also comprises cleaning head support (61-6); Cleaning head (61) is fixed on cleaning head support (61-6) by its cleaning head main body (61-1); The front-end and back-end on the right side of cleaning head support (61-6) are provided with hook (61-6-1);
The jacking gear (62) of described wiper mechanism (6) comprises framework (62-1), riser guide parts (62-2), elevating screw parts (62-3), lifting motor (62-4), lifting driving member (62-5), lifting sensing chip (62-7) and lifting optoelectronic switch (62-8);
Framework (62-1) comprises framework front side board (62-1-1), framework back side panel (62-1-2), frame head plate (62-1-3), chassis base (62-1-4); The front end of frame head plate (62-1-3) is fixedly connected with the upper end of framework front side board (62-1-1), the rear end of frame head plate (62-1-3) is fixedly connected with the upper end of framework back side panel (62-1-2), the front end of chassis base (62-1-4) is fixedly connected with the lower end of framework front side board (62-1-1), and the rear end of chassis base (62-1-4) is fixedly connected with the lower end of framework back side panel (62-1-2);
Riser guide parts (62-2) comprise riser guide (62-2-1), lifting slider (62-2-2) and lifter plate (62-2-3); Riser guide (62-2-1) upward and downward is horizontally disposed with, and is fixed on framework back side panel (62-1-2) from the place ahead, and is positioned at the right part of framework back side panel (62-1-2); Lifting slider (62-2-2) is arranged on riser guide (62-2-1), can slide up and down along riser guide (62-2-1); Lifter plate (62-2-3) is fixed on lifting slider (62-2-2) from the place ahead;
Elevating screw parts (62-3) comprise elevating screw (62-3-1), elevating screw nut (62-3-2), lifting holder (62-3-3), elevating screw bearing (62-3-4); It is upper that lifting holder (62-3-3) is enclosed within elevating screw nut (62-3-2), and elevating screw nut (62-3-2) is fixed on lifting holder (62-3-3); Lifting holder (62-3-3) is fixed on lifter plate (62-2-3) from the place ahead; The right part of frame head plate (62-1-3) offers the dead eye of up/down perforation, and elevating screw bearing (62-3-4) is fixed on this dead eye place; Elevating screw (62-3-1) is vertical to be arranged, and through elevating screw nut (62-3-2), and is meshed with elevating screw nut (62-3-2); The upper end of elevating screw (62-3-1), through elevating screw bearing (62-3-4), protrude upward;
The left part of frame head plate (62-1-3) offers the motor hole of up/down perforation; Lifting motor (62-4) is fixed on frame head plate (62-1-3) left part from below; The upper end of the motor shaft of lifting motor (62-4) through the motor hole of frame head plate (62-1-3), protrudes upward from bottom to top;
Lifting driving member (62-5) comprises lifting synchronous pulley (62-5-1) and lifting Timing Belt (62-5-2); Lifting synchronous pulley (62-5-1) has 2, wherein 1 lifting synchronous pulley (62-5-1) is enclosed within on the upper end of elevating screw (62-3-1), and be fixedly connected with elevating screw (62-3-1), another 1 lifting synchronous pulley (62-5-1) is enclosed within on the motor shaft of lifting motor (62-4), and is fixedly connected with the motor shaft of lifting motor (62-4); It is upper that lifting Timing Belt (62-5-2) is enclosed within 2 lifting synchronous pulleys (62-5-1), and be meshed with lifting synchronous pulley (62-5-1);
Crane (62-6) comprises crane substrate (62-6-1) and crane crossbeam (62-6-2); Crane substrate (62-6-1) vertically arranges, and before and after crane crossbeam (62-6-2), to being horizontally disposed with, crane crossbeam (62-6-2) is connected to the top of crane substrate (62-6-1) by its rear end; The front end of crane crossbeam (62-6-2) and middle part are equipped with hook portion (62-6-3), and the hook (61-6-1) of cleaning head support (61-6) is stuck in the hook portion (62-6-3) of crane crossbeam (62-6-2); Crane (62-6) by its crane substrate (62-6-1) from the right-hand right side that is fixed on lifting holder (62-3-3);
It is upper that lifting sensing chip (62-7) is fixed on lifting holder (62-3-3), and be positioned at the upper left quarter of the front side of lifting holder (62-3-3); Lifting optoelectronic switch (62-8) has 3, all from the place ahead, is fixed on framework front side board (62-1-1); Lifting sensing chip (62-7) is to match with lifting optoelectronic switch (62-8), the electrical equipment of feedback lifting position signal;
The pump assembly (63) of described wiper mechanism (6) also comprises bumper support (63-6) and pump groove (63-7); Pump groove (63-7) opening upwards, be fixed on the left back section of base plate (100); Suction pumps (63-4) and liquid charge pump (63-1) all are positioned at pump groove (63-7), and are fixed on pump groove (63-7); The main body of bumper support (63-6) is horizontally disposed with, and its right part bends downwards, and bumper support (63-6) is fixed on frame head plate (62-1-3) by its right lateral bend folding part; Impact damper (63-2) is fixed on the left part of bumper support (63-6) from below, solenoid valve (63-3) is fixed on the middle part of bumper support (63-6) from below.
2. according to full-automatic reaction instrument claimed in claim 1, it is characterized in that: also comprise bottle for handling liquid toilet or cosmetic substance (101), waste liquid bottle (102) and surge flask (103);
The cleaning head (61) of described wiper mechanism (6) comprises cleaning head main body (61-1), water injection pipe (61-2), suction hose (61-3), water filling interface (61-4), water outlet mouthpiece (61-5); Cleaning head main body (61-1) is strip, along front and back to being horizontally disposed with; Water filling interface (61-4), water outlet mouthpiece (61-5) all are arranged on the top of cleaning head main body (61-1); Water injection pipe (61-2) has 6 to 12, vertically arranges, along front and back to being arranged in a row; Each root water injection pipe (61-2) is fixedly connected on the bottom of cleaning head main body (61-1) by its top, each root water injection pipe (61-2) is connected with water filling interface (61-4); The quantity of suction hose (61-3) is identical with the quantity of water injection pipe (61-2), vertically arranges, along front and back to being arranged in a row; Each root suction hose (61-3) is fixedly connected on the bottom of cleaning head main body (61-1) by its top, and is positioned at the right side of corresponding separately water injection pipe (61-2), and each root suction hose (61-3) is connected with water outlet mouthpiece (61-5); The length of water injection pipe (61-2) is less than the length of suction hose (61-3), and the caliber of water injection pipe (61-2) is less than the caliber of suction hose (61-3);
The pump assembly (63) of described wiper mechanism (6) comprises liquid charge pump (63-1), impact damper (63-2), solenoid valve (63-3) and suction pumps (63-4); Bottle for handling liquid toilet or cosmetic substance is equipped with washing lotion in (101), with the airtight flexible pipe be connected of the inlet of liquid charge pump (63-1), stretches in the washing lotion of bottle for handling liquid toilet or cosmetic substance (101); The liquid outlet of liquid charge pump (63-1) is airtight being connected of inlet with impact damper (63-2) by flexible pipe; The liquid outlet of impact damper (63-2) is by airtight being connected of water filling interface (61-4) of flexible pipe with cleaning head (61) through solenoid valve (63-3); The water outlet mouthpiece (61-5) of cleaning head (61) is by flexible pipe and airtight being connected of waste liquid bottle (102); Waste liquid bottle (102) is by flexible pipe and airtight being connected of surge flask (103); Surge flask (103) is by flexible pipe and airtight being connected of air intake opening with suction pumps (63-4).
3. according to the described full-automatic reaction instrument of claim 1 or 2, it is characterized in that: described article carrying platform (2) also comprises rinse bath (22), 2 guide rods (24), 4 guide pin bushings (25), 2 stage clips (26), sealing gasket (27), pressing plate (28) and baffle plate (29);
Objective table (21) comprises objective table main body (21-1) and 2 objective table slide blocks (21-2); The upper surface of objective table main body (21-1) offers 2 stopper slots (21-1-1) and 1 waste liquid tank (21-1-2); Waste liquid tank (21-1-2) be shaped as strip, front and back, to setting, are positioned at the right side of right side stopper slot (21-1-1); The bottom of stopper slot (21-1-1) and waste liquid tank (21-1-2) offers 3 to 10 left and right to the diversion trench (21-1-3) that stopper slot (21-1-1) and waste liquid tank (21-1-2) are interconnected together arranged; All one in front and one in back offer 2 left and right on 2 objective table slide blocks (21-2) to the circular hole connected; 2 objective table slide blocks (21-2) are divided into left side objective table slide block (21-2-1) and right side objective table slide block (21-2-2), left side objective table slide block (21-2-1) is connected to objective table main body (21-1) from below, and be positioned at the left side central portion of objective table main body (21-1), right side objective table slide block (21-2-2) is connected to objective table main body (21-1) from below, and is positioned at the right side central of objective table main body (21-1); Baffle plate (29) vertically arranges, from the right-hand right flank that is fixed on objective table main body (21-1);
Stage carrier assembly (23) comprises fore-stock (23-1), after-poppet (23-2), left side tie-beam (23-3), middle part tie-beam (23-4) and right side tie-beam (23-5); Fore-stock (23-1) is identical with the shape of after-poppet (23-2), includes foot rest and crossbeam separately, and crossbeam is connected to the top of foot rest by its left end head; Fore-stock (23-1) and after-poppet (23-2) one in front and one in back are symmetrical arranged; Left side tie-beam (23-3), middle part tie-beam (23-4) and right side tie-beam (23-5) all front and back, to setting, and are sequentially arranged according to order from left to right between the crossbeam of the crossbeam of fore-stock (23-1) and after-poppet (23-2); The front end of left side tie-beam (23-3), middle part tie-beam (23-4) and right side tie-beam (23-5) all is fixedly connected on the crossbeam of fore-stock (23-1), and the rear end of left side tie-beam (23-3), middle part tie-beam (23-4) and right side tie-beam (23-5) all is fixedly connected on the crossbeam of after-poppet (23-2);
Rinse bath (22) opening upwards, the fore-stock (23-1) and the after-poppet (23-2) that are fixed on stage carrier assembly (23) are upper, and are positioned at the upper right side of stage carrier assembly (23); Sealing gasket (27) and pressing plate (28) all vertically arrange, the right flank setting of the adjacent rinse bath of sealing gasket (27) (22), and pressing plate (28) is positioned at the right-hand of sealing gasket (27), and pressing plate (28) is fixed on rinse bath (22) from right-hand;
4 guide pin bushings (25) are separately fixed in 2 circular holes of 2 circular holes of left side objective table slide block (21-2-1) and right side objective table slide block (21-2-2); 2 guide rods (24) are all along left and right to being horizontally disposed with, and respectively from left to right successively through guide pin bushing (25) and right side tie-beam (23-5) on the guide pin bushing (25) on left side tie-beam (23-3), sealing gasket (27), pressing plate (28), left side objective table slide block (21-2-1), middle part tie-beam (23-4), corresponding stage clip (26), right side objective table slide block (21-2-2), and with left side tie-beam (23-3), middle part tie-beam (23-4) and right side tie-beam (23-5) wringing fit; The left end head of 2 stage clips (26) contacts with middle part tie-beam (23-4), and the right-hand member head of 2 stage clips (26) contacts with right side objective table slide block (21-2-2); It is upper that objective table (21) is slidably connected at guide rod (24) by guide pin bushing (25), and stage clip (26) applies direction power to the right to objective table (21) all the time by self elastic force.
4. according to full-automatic reaction instrument claimed in claim 3, it is characterized in that: described translation mechanism (1) comprises translation track segment (11), translation base plate (12), translation screw mandrel parts (13), translation motor parts (14) and translation driving member (15);
Translation track segment (11) comprises translation guide rail (11-1), translation slide block (11-2) and right side block (11-4); Translation guide rail (11-1) left and right, to being horizontally disposed with, is fixed on base plate (100) from top, and is positioned at the front portion of base plate (100); Translation slide block (11-2) is arranged on translation guide rail (11-1); Right side block (11-4) comprises riser (11-4-1), horizontal base plate (11-4-2) and base (11-4-3), horizontal base plate (11-4-2) is connected with the top of riser (11-4-1) by its left part, and base (11-4-3) is connected with the bottom of riser (11-4-1) by its left part; It is upper that right side block (11-4) is fixed on base plate (100) by its base (11-4-3), and the right-hand member of adjacent translation guide rail (11-1);
Being fixedly connected on translation slide block (11-2) from top of translation base plate (12); Article carrying platform (2) is fixed on translation base plate (12) from top by its stage carrier assembly (23);
Translation screw mandrel parts (13) comprise translation screw mandrel (13-1), translation feed screw nut (13-2), translation holder (13-3), peaceful silk shifting rod bearing (13-4); It is upper that translation holder (13-3) is enclosed within translation feed screw nut (13-2), and translation feed screw nut (13-2) is fixed on translation holder (13-3); Translation holder (13-3) is fixed on translation base plate (12) from top; Have through hole on the riser (11-4-1) of the right side block (11-4) of translation track segment (11), translation screw mandrel bearing (13-4) is fixed on the through hole of riser (11-4-1); Translation screw mandrel (13-1) left and right, to being horizontally disposed with, through translation feed screw nut (13-2), and is meshed with translation feed screw nut (13-2); The right-hand member head of translation screw mandrel (13-1), through translation screw mandrel bearing (13-4), stretch out to the right;
Translation motor parts (14) comprise translation motor (14-1) and translation motor cabinet (14-2); Offer the motor hole (14-2-1) that left and right connects on translation motor seat (14-2); Translation motor seat (14-2) is fixed on base plate (100) from top, and is positioned at the rear of the right side block (11-4) of translation track segment (11); Translation motor (14-1) is fixed on translation motor seat (14-2) from left, and the right-hand member head of the motor shaft of translation motor (14-1) through the motor hole (14-2-1) on translation motor seat (14-2), stretches out to the right from left to right;
Translation driving member (15) comprises translation synchronous pulley (15-1) and translation Timing Belt (15-2); Translation synchronous pulley (15-1) has 2, wherein 1 translation synchronous pulley (15-1) is enclosed within on the right-hand member head of translation screw mandrel (13-1), and be fixedly connected with translation screw mandrel (13-1), another 1 translation synchronous pulley (15-1) is enclosed within on the motor shaft of translation motor (14-1), and is fixedly connected with the motor shaft of translation motor (14-1); It is upper that translation Timing Belt (15-2) is enclosed within 2 translation synchronous pulleys (15-1), and be meshed with translation synchronous pulley (15-1).
5. according to full-automatic reaction instrument claimed in claim 4, it is characterized in that: also comprise and connect liquid bath (5); Connect liquid bath (5) for top and right-hand all unlimited box bodys, connect on the base plate of liquid bath (5) and offer along left and right to the strip hole (51) arranged, the right-hand member in strip hole (51) communicates with the right side boundary of the base plate that connects liquid bath (5), the width in strip hole (51) equals the width of translation guide rail (11-1), and the edge of the edge of strip hole (51) and the base plate that connects liquid bath (5) is equipped with the flanging (52) that the direction that is connected makes progress; Connecing liquid bath (5) is fixed on base plate (100) from top, and be positioned at the left front section of base plate (100), left section of translation guide rail (11-1) is positioned at the strip hole (51) that connects liquid bath (5), and the base plate that connects liquid bath (5) is positioned at the below of translation base plate (12) and left side block (11-3).
6. according to full-automatic reaction instrument claimed in claim 5, it is characterized in that: described constant temperature oven parts (3) comprise constant temperature oven (31), constant temperature oven base (32), temperature inductor (33) and translation optoelectronic switch (34);
Constant temperature oven (31) comprises constant temperature oven shell (31-1), constant temperature oven inner bag (31-2), constant temperature oven fan (31-3), constant temperature oven junction block (31-4) and constant temperature oven upper cover (31-5); Constant temperature oven shell (31-1) is all unlimited box bodys of top and left, and the front and rear of the right plate of constant temperature oven shell (31-1) is equipped with the fan installation portion (31-1-1) of projection to the right; Constant temperature oven inner bag (31-2) comprises heating cabinet (31-2-1), left plate (31-2-2), right plate (31-2-3) and crossbeam (31-2-4); The inner chamber left and right of heating cabinet (31-2-1), to perforation, is provided with heating arrangement between the inner and outer wall of heating cabinet (31-2-1); The central position of left plate (31-2-2) and right plate (31-2-3) all offers the through hole identical with the inner chamber size of heating cabinet (31-2-1); Left plate (31-2-2) vertically arranges, and is fixed on heating cabinet (31-2-1) by the edge of its through hole upper, and is positioned at the left side of heating cabinet (31-2-1), and the through hole on left plate (31-2-2) is the opening of constant temperature oven (31); Right plate (31-2-3) vertically arranges, and is fixed on heating cabinet (31-2-1) by the edge of its through hole upper, and is positioned at the right side of heating cabinet (31-2-1); Crossbeam (31-2-4) front and back are to being horizontally disposed with, its front end is connected to the forward edge place of the through hole of right plate (31-2-3), its rear end is connected to the posterior edges place of the through hole of right plate (31-2-3), thereby the through hole of right plate (31-2-3) is divided into to upper and lower two parts; Constant temperature oven inner bag (31-2) is positioned at constant temperature oven shell (31-1), the left plate (31-2-2) of constant temperature oven inner bag (31-2) is positioned at the left side opening part of incubator shell (31-1), the fan installation portion (31-1-1) of the adjacent constant temperature oven shell of right plate (31-2-3) (31-1) of constant temperature oven inner bag (31-2); Constant temperature oven fan (31-3) has 2, is separately fixed in the corresponding fan installation portion (31-1-1) of constant temperature oven shell (31-1); 2 constant temperature oven fans (31-3) are horizontally disposed with, and are positioned at the right side of the crossbeam (31-2-4) of constant temperature oven inner bag (31-2), and air-out direction is downward; Junction block (31-4) is fixed on the back side panel of constant temperature oven shell (31-1); The airtight upper opening place that is fixed on constant temperature oven shell (31-1) of constant temperature oven upper cover (31-5);
Constant temperature oven base (32) comprises seat board (32-1), left front leg (32-2), right front leg (32-3), left back leg (32-4) and right back leg (32-5); Left front leg (32-2), right front leg (32-3), left back leg (32-4) and right back leg (32-5) are connected to seat board (32-1) from below by its upper end, and lay respectively at left side front end, right side front end, rear end, left side and the rear end, right side of seat board (32-1); Constant temperature oven base (32) is fixed on the bottom of constant temperature oven shell (31-1) by its seat board (32-1);
The probe of temperature inductor (33) is through the right plate of constant temperature oven shell (31-1), stretch in the inner chamber of heating cabinet (31-2-1) of constant temperature oven inner bag (31-2), temperature inductor (33) is fixed on the right plate of constant temperature oven shell (31-1) by its pedestal;
Translation optoelectronic switch (34) has 3, is divided into translation limit on the left switch (34-1), translation origin switch (34-2) and translation limit on the right-right-hand limit switch (34-3); Translation limit on the left switch (34-1) is fixed on the left front leg (32-2) of constant temperature oven base (32) from rear; Translation origin switch (34-2) and translation limit on the right-right-hand limit switch (34-3) all are fixed on the right front leg (32-3) of constant temperature oven base (32) from rear, and translation origin switch (34-2) is positioned at the left side of translation limit on the right-right-hand limit switch (34-3);
Translation mechanism (1) also comprises translation sensing chip (16); Translation sensing chip (16) is fixed on translation base plate (12) from top, and is positioned at the right front portion of translation base plate (12), and the front side of translation sensing chip (16) is provided with protuberance, and its protuberance is positioned at outside translation base plate (12); Translation sensing chip (16) on translation base plate (12) is to match with translation optoelectronic switch (34), the electrical equipment of feedback translation position signalling;
Constant temperature oven parts (3) are fixed on base plate (100) from top by the left front leg (32-2) of its constant temperature oven base (32), right front leg (32-3), left back leg (32-4) and right back leg (32-5), and be positioned at translation guide rail (11-1) top, connect the right side of liquid bath (5).
7. according to full-automatic reaction instrument claimed in claim 6, it is characterized in that: described oscillating mechanism (4) also comprises vibration motor (41), vibration motor installing plate (42), vibration support (43), eccentric wheel (44), vibration bearing (45), vibration cam (46), vibration connecting rod (47) and lining (49); Vibration push rod (48) is the oscillating member of oscillating mechanism (4);
Vibration support (43) comprises vibration stent substrate (43-1) and vibration rack side plate (43-2), vibration rack side plate (43-2) is along front and back to vertical setting, be connected to the left end of vibration stent substrate (43-1) from top, offer left and right on vibration rack side plate (43-2) to the circular hole connected; Lining (49) passes the circular hole on vibration rack side plate (43-2), and is fixed on vibration rack side plate (43-2); Vibration motor installing plate (42) is along left and right to vertical setting, vibration motor installing plate (42) is fixed on vibration stent substrate (43-1) from top, and be positioned at vibration stent substrate (43-1) rear side, offer front and back on vibration motor installing plate (42) to the hole connected; It is upper that vibration motor (41) is fixed on vibration motor installing plate (42), and be positioned at the rear of vibration motor installing plate (42); The motor shaft of vibration motor (41), through the hole on vibration motor installing plate (42), stretches out forward; Eccentric wheel (44) is fixed on the front end of motor shaft of vibration motor (41), and before and after the front side of eccentric wheel (44) is provided with, to horizontally disposed axle, the front end of axle is provided with screw thread; Vibration bearing (45) axial limiting is on the axle of eccentric wheel (44); Vibration cam (46) comprises round plate (46-1) and is arranged on the protuberance (46-2) in round plate (46-1) left side, the central authorities of round plate offer circular hole, vibration cam (46) is upper at vibration bearing (45) by the circle hole sleeve of its round plate (46-1), and with the outer ring wringing fit of vibration bearing (45); Vibration connecting rod (47) is along the left and right horizontal setting, and the right-hand member of vibration connecting rod (47) is hinged with the left end of the protuberance (46-2) of vibration cam (46); Vibration push rod (48) is along the left and right horizontal setting, and the right-hand member of vibration push rod (48) is fixedly connected on the left end of vibration connecting rod (47) by fixed pin, and vibration push rod (48) stretches out to the right through lining (49);
Oscillating mechanism (4) is fixed on the right side block (11-4) of translation track segment (11) from top by the vibration stent substrate (43-1) of its vibration support (43), and is positioned at the top of right side block (11-4); The right plate of the constant temperature oven shell (31-1) of the adjacent constant temperature oven of vibration rack side plate (43-2) (31) of oscillating mechanism (4); The position be positioned between 2 fan installation portions (31-1-1) of the right plate of constant temperature oven shell (31-1) offers push-rod hole (31-1-2), lining (49) is through the push-rod hole (31-1-2) of constant temperature oven shell (31-1), and vibration push rod (48) stretches in the constant temperature oven inner bag (31-2) of constant temperature oven (31).
8. according to full-automatic reaction instrument claimed in claim 7, it is characterized in that: described case member (8) also comprises left cover (82), right cover (83), power supply fan (84) and feet (88);
Upper casing (81) is the downward housing of lumen openings, and the right part of the back side panel of upper casing (81) offers thermovent (81-3); Left cover (82) and right cover (83) are all transparent; It is upper that left cover (82) is rotatably connected on upper casing (81) by its rear end, and be positioned at the top of upper casing (81) left part; It is upper that right cover (83) is rotatably connected on upper casing (81) by its rear end, and be positioned at the top of upper casing (81) right part; Power supply fan (84) is fixed on the thermovent (81-3) of upper casing (81) and locates, and air-out direction backward;
The housing that lower casing (87) makes progress for lumen openings, the left side of lower casing (87) and right side are equipped with the carrying attacker section (87-1) concaved, feet (88) has 4, all from below, be fixed on lower casing (87), and lay respectively at the left front section of lower casing (87), left back section, right front portion and right back section.
9. according to full-automatic reaction instrument claimed in claim 8, it is characterized in that: described case member (8) also comprises lock buckling part (86); Lock buckling part (86) comprises snap close (86-1), snap close pressing plate (86-2), snap close bearing (86-3) and snap close bearing axle (86-4); It is upper that snap close bearing (86-3) is fixed on upper casing (81), and be positioned at the left back section of upper casing (81), the left side of left cover (82); Snap close bearing axle (86-4) left and right, to being horizontally disposed with, is fixed on snap close bearing (86-3) by its left end; The left part of snap close (86-1) is provided with the buckle (86-1-1) that direction arranges downward vertically, and buckle (86-1-1) is provided with opening groove forward, and the position of this groove is corresponding with the position of snap close bearing axle (86-4); The left back section of left cover (82) offers the sagittal groove (82-1) that slides, the place ahead of sliding groove (82-1) of left cover (82) is provided with the downward front side reference column (82-2) of direction, and the rear of sliding groove (82-1) of left cover (82) is provided with the downward rear side reference column (82-3) of direction; The front end of snap close pressing plate (86-2) is provided with front card interface (86-2-1), and the rear end of snap close pressing plate (86-2) is provided with rear card interface (86-2-2); Snap close pressing plate (86-2) is fixed on snap close (86-1) through the groove (82-1) that slides of left cover (82).
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| CN201110339028.4A CN102507964B (en) | 2011-10-31 | 2011-10-31 | Full-automatic reactor |
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| CN201110339028.4A CN102507964B (en) | 2011-10-31 | 2011-10-31 | Full-automatic reactor |
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| CN103592453B (en) * | 2013-11-22 | 2015-03-11 | 齐齐哈尔医学院 | Sample injector of analysis instrument |
| CN106733886B (en) * | 2016-12-20 | 2023-03-24 | 上海长海医院 | Full-automatic high-efficient western blot membrane washing system |
| US20220178955A1 (en) * | 2019-04-11 | 2022-06-09 | Hitachi High-Tech Corporation | Automatic analyzer |
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| CN1825115A (en) * | 2005-02-24 | 2006-08-30 | 穆海东 | Biochip reaction apparatus |
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Effective date of registration: 20180507 Address after: 210000 2 2 Shengan Road, Binjiang Economic Development Zone, Jiangning District, Nanjing, Jiangsu. Patentee after: Nanjing Yulong Biomedical Development Co.,Ltd. Address before: 200233 fourth floor, 50 plant fourth, Qinzhou North Road, Xuhui District, Shanghai. Patentee before: Shanghai Yulong Biotech Co.,Ltd. |
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Application publication date: 20120620 Assignee: Shanghai Lingang Financial Leasing Co.,Ltd. Assignor: Shanghai Yulong Biotech Co.,Ltd. Contract record no.: X2022980015555 Denomination of invention: Automatic Reactor Granted publication date: 20131218 License type: Exclusive License Record date: 20220919 |
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Denomination of invention: Automatic Reactor Effective date of registration: 20220920 Granted publication date: 20131218 Pledgee: Shanghai Lingang Financial Leasing Co.,Ltd. Pledgor: Shanghai Yulong Biotech Co.,Ltd. Registration number: Y2022980015779 |
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