CN2775658Y - Biological chip reaction instrument - Google Patents
Biological chip reaction instrument Download PDFInfo
- Publication number
- CN2775658Y CN2775658Y CN 200520039759 CN200520039759U CN2775658Y CN 2775658 Y CN2775658 Y CN 2775658Y CN 200520039759 CN200520039759 CN 200520039759 CN 200520039759 U CN200520039759 U CN 200520039759U CN 2775658 Y CN2775658 Y CN 2775658Y
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- reaction apparatus
- temperature
- objective table
- biochip
- box body
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Abstract
The utility model relates to a reaction instrument for biological chips, which comprises a main box body, an object stage and a constant-temperature reaction device, wherein a control circuit board, a pump, an electromagnetic valve, a pressure regulating device, a vertical movement mechanism and a horizontal movement mechanism are arranged in the main box body; a cleaning head is connected with the vertical movement mechanism; the object stage is connected with the horizontal movement mechanism; one side of the object stage is provided with the constant-temperature reaction device; a box body of the constant-temperature reaction device is made of multiple-layer heat resistance materials; heating devices uniformly distributed are arranged in an interlayer; an air circulation device and a plurality of temperature sensors are arranged in the box body; the front wall of the box body is provided with a moveable door, and thus, the box body is kept closed when the chip is carried out with an oscillating reaction. A control system sets each parameter, automatically completes operation steps, monitors the instrument state in real time and instantly displays results on a liquid crystal device. The utility model combines the process of a constant-temperature reaction and the process of wash into a whole with one instrument with multiple functions, is suitable for the biological chips compatible with an ELISA battens, and has the advantages of simple and convenient operation, high automation, high precision, safety and no pollution.
Description
Technical field
The utility model relates to the reaction and the cleaning equipment of the robotization in clinical medical inspection and the chemical analysis, exactly, be a kind of, integrate constant temperature, vibration, cleaning function at biochip, and the reaction and the washing facility of the robotization of the compatible elisa plate bar of energy.
Background technology
Biochip technology is to have new and high technology characteristics of the times, that interdisciplinary studies such as collection physics, microelectronics and molecular biology intersect to form in the high-technology field in recent years.Microfluid analysis unit and system that it mainly makes up by the plane Micrometer-Nanometer Processing Technology detect with accurate, quick, the large information capacity of realizing pair cell, protein, nucleic acid and other biological components.This technological breakthrough the limitation of traditional method of inspection, have detect flux greatly, accurately and fast, advantage such as trace, numerous areas such as immunodiagnosis, gene diagnosis, functional gene research, genomic library figure type analysis, new medicament screen, Food Inspection, medical jurisprudence have been widely used in, also be the inexorable trend of following clinical examination diagnostic field development, many indexs, parallel, have the classic method incomparable advantage aspect making a definite diagnosis fast.Biochip and support equipment biochip supplies analysis, biochip reaction apparatus are formed detection system, have demonstrated fully the characteristics such as robotization, systematization, informationization of advanced medical diagnosis on disease technology.And in biochip or ELISA experiment, reaction fully, rational mode of washing are to guarantee its result necessary condition accurately and reliably.
At present, only be directed to the plate machine of washing of ELISA on the market, also be not directed to the plate machine of washing of chip film washing, more will not react and wash the reaction instrument that both combine.Existing ELISA washes the plate machine, as Chinese patent notification number CN2276635Y " ELIAS microplate washer automatically ", ingredients such as appliance controling plate, pump, worktable, vertical movement mechanism, horicontal motion mechanism have been included only, its objective table of placing the elisa plate bar is relatively simple for structure, the anchor clamps mode of the groove that is complementary with the elisa plate bar is made in employing on objective table, the one side is fixed on the horicontal motion mechanism, and opposite side slides on surface level by a slide block.And the Bioexperiment of reacting based on ELISA at present all is the pattern operation by reacting on independent constant temperature shaking table instrument, biochip is to grow up on the basis of ELISA, still continued the operator scheme of reacting, so also do not have on the plate machine to occur to supply the thermostat of ELISA or chip isothermal reaction in washing before by on independent constant temperature shaking table instrument.No matter consider from isothermal reaction and washing, vibration individual feature module, still from the reaction of constant temperature shaking table add wash the plate machine this operator scheme on the whole, all have certain defective.
One, consider that from reaction or washing individual feature existing constant temperature shaking table and ELISA wash the plate machine and have certain defective:
1. temperature uniformity in the temperature-controlling reaction apparatus casing, stability, accuracy are all poor, and bulky.(see that specifically the temperature-controlling reaction apparatus separate case applies for a patent.)
2. objective table adopts the simple anchor clamps mode of the groove that is complementary with the elisa plate bar on objective table, though the elisa plate bar can be fixed on the objective table, not only influences kinematic accuracy and serviceable life, but also pollutes easily and instrument failure.(objective table separate case is applied for a patent.)
3. control the amount of the every hole of elisa plate bar liquid feeding volume by the time of control liquid stream, form is single, can't satisfy increasingly sophisticated biomedicine and detect requirement.
4. programmed control can't be satisfied the unique washing requirement of chip at the wash conditions design of ELISA grade strip.
Two, this constant temperature shaking table reaction adds the conventional mode of operation of washing the plate machine, though can satisfy the function that detects at present substantially, has following deficiency:
1. operate loaded down with trivial details: all need carry out on two kinds of equipment owing to whenever finish single job, the transmission of equipment room also must be finished by the people, operates loaded down with trivial details.
2. test period is long: owing to all having the reaction of 2 steps, each test finishes with repeatedly vibrating, if it is by manually-operated, complicated, consuming time.
3. test error is bigger: the equipment of use is many more, and the error of being brought by every equipment is many more, and manually-operated also brings more operate miss.
Therefore, it is a kind of at biochip that this area presses for exploitation, integrates chip film reaction and washing function, simultaneously isothermal reaction, vibration and the cleaning device of also compatible elisa plate bar.And the biochip reaction apparatus that the utility model relates to has met such demand just, not only integrates these several functions, can finish all operations automatically, and can also satisfy the personalized requirement of ELISA, chip.
Summary of the invention
The purpose of this utility model is at the problems referred to above, a kind of brand-new isothermal reaction that biochip and the various detections of enzyme linked immunological (ELISA) require and device of cleaning of going for is provided, and be one with cleaning, vibration and the isothermal reaction collection of biochip or elisa plate bar, overcome the existing plate machine of washing effectively only at the elisa plate bar, and washing needs minute two equipment to carry out with reaction, and the defective of can't robotization finishing.Design ingenious, can be according to the different running program of the various biochips requirement different design with ELISA, full-automatic complete operation process, easy to use, and can draw waste reaction solution at any time, prevent the influence of waste liquor contamination and liquid leakage to instrument; When chip or ELISA carried out the constant temperature oscillating reactions, the temperature-controlling reaction apparatus casing was airtight good, and temperature stabilization is even in the casing, detects safety non-pollution, the automaticity height, and the result is accurately stable.
The purpose of this utility model is achieved in that
The utility model provides a kind of biochip reaction apparatus, include main box, objective table and temperature-controlling reaction apparatus, be provided with control circuit board, pump, solenoid valve, pressure adjustment assembly, vertical movement mechanism and horicontal motion mechanism in the main box, cleaning head is connected in vertical movement mechanism, and objective table is connected in horicontal motion mechanism.Objective table is separated into waste liquid tank and chip placing district, but both bottoms are communicated with by hole, groove, and bottom surface, the chip placing district low-angle that tilts, making the waste liquid tank bottom surface is whole groove floor extreme lower position, also be provided with the dodge gate that cooperates with temperature-controlling reaction apparatus on the objective table, this dodge gate can move with objective table.Temperature-controlling reaction apparatus is arranged on worktable one side, this thermostat casing is made up of multiple layer heat proof material, equally distributed heater members is arranged in the interlayer, air circulation device and a plurality of temperature sensor are set in the casing, casing and the dodge gate that is arranged on the objective table cooperate, when making objective table drive chip or elisa plate bar carry out oscillating reactions in casing, casing still can remain airtight.
The utility model provides pump, pressure adjustment assembly and solenoid valve.By pressure adjustment assembly, regulate the pressure in the liquid feeding bottle, control adds flow velocity; By the break-make of circuit controling electromagnetic valve, the control liquid feeding time.By liquid volume added is controlled in the control that adds hydraulic coupling and time.Each detects the liquid feeding volume in hole and then regulates by the liquid feeding height of control cleaning head.
The utility model provides a kind of control circuit board and LCD, control circuit can setting and storage reaction and washing procedure, can set elisa plate bar and chip location parameter separately in the program respectively, and the program parameter that satisfies all kinds ELISA, chip reaction and washing requirement, the robotization of realization response and washing, all right real-time monitor (RTM) state, and be shown on the LCD, realize man-machine conversation.(this program separate case application copyright protection)
The utility model provides a kind of novel objective table, and novel temperature-controlling reaction apparatus.(objective table and temperature-controlling reaction apparatus separate case are applied for a patent)
The utility model is compared with the obvious advantage with prior art:
1. the objective table that provides of the utility model can not only compatible biochip and elisa plate bar, and keeps its horizontality that is installed, but also has the function of collecting waste liquid, has reduced the possibility of polluting and influence the instrument operate as normal.
2. the temperature-controlling reaction apparatus that provides of the utility model is provided with dodge gate, air circulation device and a plurality of temperature sensing device, can well keep the leakproofness of temperature-controlling reaction apparatus casing, the homogeneity of temperature, stability and accuracy.
3. the utility model has not only reduced number of devices with the temperature-controlling reaction apparatus miniaturization and combine and wash plate machine function, has dwindled equipment occupation space, has also saved equipment cost.
4. the control circuit and the program that provide of the utility model, require relative higher biochip to design at reaction and washing, and can compatible elisa plate bar, by different reaction of each parameter designing and washing procedure are set, can satisfy various dissimilar biochips and elisa plate bar.
5. the utility model not only can be controlled liquid volume added, the accuracy height by controlling the liquid feeding time and adding two aspects of hydraulic coupling.
6. the utility model can automatically be finished the reaction and the washing procedure of biochip or elisa plate bar, has not only reduced personnel's work load, has also saved the running time, and has greatly reduced test error.
Description of drawings
Figure .1 is a structural representation of the present utility model;
Figure .2 is a pipeline connection diagram of the present utility model;
Embodiment
Below in conjunction with drawings and Examples the utility model is further specified.
See also shown in Figure 1, the utility model includes main box 1, worktable 3, objective table 5 and temperature-controlling reaction apparatus 8, be provided with control circuit board 9, pump 13, solenoid valve 16, pressure adjustment assembly 17, vertical movement mechanism 10 and horicontal motion mechanism 2 in the main box 1, cleaning head 6 is connected on the vertical movement mechanism 10, objective table 5 is connected on the horicontal motion mechanism 2, is connected with dodge gate 4 on the objective table 5.Main box 1 is provided with control button 11 and LCD 12.
Objective table 5 is separated into waste liquid tank and chip placing district, and objective table 5 is provided with dodge gate 4.Temperature-controlling reaction apparatus 8 is arranged on a side of worktable 3, and casing 8 and dodge gate 4 cooperate, and makes casing airtight good (objective table and temperature-controlling reaction apparatus separate case are applied for a patent).
See also shown in Figure 2, be provided with pump 13, pressure adjustment assembly 17 and solenoid valve 16 in the main box, pipeline is connected with each other, receive the time of cleaning head 6, liquid feeding bottle 15 and waste liquid bottle 14 circuit control panels 9 and programmed control solenoid valve 16 control liquid feedings, the Comprehensive Control that adds hydraulic coupling and time is advanced your control cleaning head 6 liquid feeding volumes.
The utility model provides a kind of control circuit board 9, LCD 12 and succinct control button 11, control circuit 9 can controlling level motion 2, vertical movement mechanism 10, air circulation device in the thermostat 8 and temperature control system, pump 13 and solenoid valve 16, and can setting and storage reaction and washing procedure in the control circuit, can set elisa plate bar and chip location parameter separately in the program respectively, and satisfy all kinds ELISA, the program parameter that reaction of chip kind and washing require, comprise wash type, temperature of reaction, the reaction oscillation intensity, reaction time, washing intensity, wash time, duration of oscillation or the like, can be according to the reaction that is provided with, washing procedure, automatically finish reaction of ELISA or chip and washing operation, and real-time monitor (RTM) state, be shown on the LCD, realize man-machine conversation.(this program separate case application copyright protection)
The utility model provides a kind of novel objective table 5 and temperature-controlling reaction apparatus 8.(objective table and temperature-controlling reaction apparatus separate case are applied for a patent)
Concrete operations step of the present utility model and principle of work are as follows:
(1) user resets elisa plate bar, chip location parameter separately according to used elisa plate bar, chip type, and preserves when first dress or when changing elisa plate bar, chip type.
When (2) using start, control program can carry out a self-examination to total system, can utilize control system to set the flushing of pipeline time after self-examination is finished earlier, and suitably flushing line prevents that other material is to the obstruction and the influence to testing of pipeline in the pipeline.
(3) parameter of setting reaction and washing according to the test needs comprises wash type, temperature of reaction, reaction oscillation intensity, reaction time, washing intensity, wash time, duration of oscillation etc., and preserves this program.
(4) send the instruction of starting working, at first horicontal motion mechanism 2 drives the objective table 5 and the dodge gate 4 that connect on it and is returned to reference position, dodge gate 4 and temperature-controlling reaction apparatus 8 keep airtight, the heater members heating, make temperature rising in the temperature-controlling reaction apparatus 8, air circulation device and temperature sensor are started working in the temperature-controlling reaction apparatus 8, make the interior temperature of casing even, and monitor temperature regime in the casing in real time.When temperature reached design temperature in the casing, chip or elisa plate bar were put in hummer and LCD 12 promptings.
(5) utilize control button 11, make objective table 5 by horicontal motion mechanism 2 in tow the stopper slot 7 on the worktable 3 move to and place chip or elisa plate bar place, ready chip or elisa plate bar are put into objective table 5, make objective table 5 move to the temperature-controlling reaction apparatus place by control button 11 again, dodge gate 4 closely contacts with casing 8, it is closed, and according to the oscillating condition starting oscillation of setting.
(6) finish according to the reaction time of setting and reaction conditions reaction after, objective table 5 is dragged to the cleaning district by horicontal motion mechanism again, driving cleaning head 6 by vertical movement mechanism 10 moves up and down, pump 13 is started working simultaneously, aspirating needle begins imbibition, when cleaning head 6 moves to setting imbibition position, keep the regular hour to determine that the liquid that detects in the hole is blotted, cleaning head 6 begins to rise then, during to high liquid level (HLL) position, solenoid valve 16 is opened, the liquid feeding pin of cleaning head 6 begins liquid feeding, closes according to setting-up time liquid feeding certain hour rear electromagnetic valve 16, and cleaning head 6 begins to rise, horicontal motion mechanism 2 drives objective tables 5 and moves to second gaging hole of listing and indexing, beginning second row's flushing ... up to having washed all detection holes, determine whether to wash again several times according to the program of setting then, perhaps finish and leave standstill according to setting, oscillatory process, and according to program instruction is set and carries out next step operation.
(7) according to reaction and the washing procedure set, automatically finish all reactions, washing, oscillatory process, be withdrawn into end position, and finish by hummer and LCD 12 prompting operation, the user can take out chip or elisa plate bar from objective table 5, carries out next step operation.
Claims (6)
1, a kind of biochip reaction apparatus is characterized in that, it contains following assembly:
One main box is provided with control circuit board, pump, solenoid valve, pressure adjustment assembly, vertical movement mechanism and horicontal motion mechanism in the described main box, cleaning head is connected in vertical movement mechanism, and objective table is connected in horicontal motion mechanism;
-objective table, described objective table one side is provided with temperature-controlling reaction apparatus;
-temperature-controlling reaction apparatus, the casing of described temperature-controlling reaction apparatus is made up of multiple layer heat proof material, and equally distributed heater members is arranged in the interlayer, and air circulation device and a plurality of temperature sensor are set in the casing, and the casing antetheca is provided with a dodge gate;
-LCD.
According to a kind of biochip reaction apparatus of claim 1, it is characterized in that 2, described reaction instrument is the integral body of washing oscillation device and temperature-controlling reaction apparatus combination; Under software control, both can realize whole interlock, and can realize function separately separately again.
According to a kind of biochip reaction apparatus of claim 1, it is characterized in that 3, the casing of described main box also is provided with LCD outward.
According to a kind of biochip reaction apparatus of claim 1, it is characterized in that 4, the groove of described objective table is separated into waste liquid tank and chip placing district, but the bottom is interconnected between the two by slit, hole or pipeline; Bottom surface, the chip placing district low-angle that tilts, making the waste liquid tank bottom surface is whole groove floor extreme lower position; Design the flexible jig support of differing heights on the base, can make the biochip or the elisa plate bar maintenance level of horizontal positioned; Base is divided in respect of reinforcement.
According to a kind of biochip reaction apparatus of claim 1, it is characterized in that 5, described objective table links to each other with horicontal motion mechanism by the U-shaped frame, is provided with a dodge gate between objective table and the U-shaped frame; Another horizontal arm of U-shaped frame and the roller devices of underarm can carry out horizontal rolling along the stopper slot on the worktable.
6, according to a kind of biochip reaction apparatus of claim 1, it is characterized in that, the dodge gate that described isothermal reaction case antetheca is provided with, independent with casing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520039759 CN2775658Y (en) | 2005-02-24 | 2005-02-24 | Biological chip reaction instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200520039759 CN2775658Y (en) | 2005-02-24 | 2005-02-24 | Biological chip reaction instrument |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN2775658Y true CN2775658Y (en) | 2006-04-26 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 200520039759 Expired - Lifetime CN2775658Y (en) | 2005-02-24 | 2005-02-24 | Biological chip reaction instrument |
Country Status (1)
| Country | Link |
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| CN (1) | CN2775658Y (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102049324A (en) * | 2009-10-30 | 2011-05-11 | 上海金发科技发展有限公司 | Device for placing high-temperature crucibles |
| CN102794279A (en) * | 2011-05-26 | 2012-11-28 | 合肥安弗朋德生物技术有限公司 | Full-automatic cleaning instrument for swing type biological experiment |
| WO2015154334A1 (en) * | 2014-04-11 | 2015-10-15 | 珠海美路得企业发展有限公司 | Biochip detection system |
| CN105176790A (en) * | 2014-05-27 | 2015-12-23 | 昆明寰基生物芯片产业有限公司 | Microarray hybridization elution instrument |
| CN106733886A (en) * | 2016-12-20 | 2017-05-31 | 上海长海医院 | A kind of full automatic high efficiency western blot wash membranous system |
| CN107583918A (en) * | 2017-08-25 | 2018-01-16 | 博奥生物集团有限公司 | A kind of semi-automated biological device for cleaning chip |
-
2005
- 2005-02-24 CN CN 200520039759 patent/CN2775658Y/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102049324A (en) * | 2009-10-30 | 2011-05-11 | 上海金发科技发展有限公司 | Device for placing high-temperature crucibles |
| CN102049324B (en) * | 2009-10-30 | 2015-01-14 | 上海金发科技发展有限公司 | Device for placing high-temperature crucibles |
| CN102794279A (en) * | 2011-05-26 | 2012-11-28 | 合肥安弗朋德生物技术有限公司 | Full-automatic cleaning instrument for swing type biological experiment |
| WO2015154334A1 (en) * | 2014-04-11 | 2015-10-15 | 珠海美路得企业发展有限公司 | Biochip detection system |
| CN105176790A (en) * | 2014-05-27 | 2015-12-23 | 昆明寰基生物芯片产业有限公司 | Microarray hybridization elution instrument |
| CN105176790B (en) * | 2014-05-27 | 2018-09-25 | 昆明寰基生物芯片产业有限公司 | Microarray hybridization elution instrument |
| CN106733886A (en) * | 2016-12-20 | 2017-05-31 | 上海长海医院 | A kind of full automatic high efficiency western blot wash membranous system |
| CN107583918A (en) * | 2017-08-25 | 2018-01-16 | 博奥生物集团有限公司 | A kind of semi-automated biological device for cleaning chip |
| CN107583918B (en) * | 2017-08-25 | 2019-08-20 | 博奥生物集团有限公司 | A kind of semi-automated biological device for cleaning chip |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shanghai Yulong Biological Science And Technology Co., Ltd. Assignor: Mu Haidong Contract fulfillment period: 2008.8.8 to 2013.8.8 Contract record no.: 2008310000195 Denomination of utility model: Biochip reaction apparatus Granted publication date: 20060426 License type: Exclusive license Record date: 20081021 |
|
| LIC | Patent licence contract for exploitation submitted for record |
Free format text: EXCLUSIVE LICENSE; TIME LIMIT OF IMPLEMENTING CONTACT: 2008.8.8 TO 2013.8.8; CHANGE OF CONTRACT Name of requester: SHANGHAI YULONG BIOLOGICAL TECHNOLOGY CO., LTD. Effective date: 20081021 |
|
| EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Shanghai Yulong Biological Science And Technology Co., Ltd. Assignor: Mu Haidong Contract record no.: 2008310000195 Date of cancellation: 20130823 |
|
| LICC | Enforcement, change and cancellation of record of contracts on the licence for exploitation of a patent or utility model | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Assignee: Shanghai Yulong Biological Science And Technology Co., Ltd. Assignor: Mu Haidong Contract record no.: 2014310000011 Denomination of utility model: Biochip reaction apparatus Granted publication date: 20060426 License type: Exclusive License Record date: 20140121 |
|
| EE01 | Entry into force of recordation of patent licensing contract | ||
| C17 | Cessation of patent right | ||
| CX01 | Expiry of patent term |
Expiration termination date: 20150224 Granted publication date: 20060426 |