CN206783658U - A kind of cell expansion system with multiple separate units - Google Patents
A kind of cell expansion system with multiple separate units Download PDFInfo
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- CN206783658U CN206783658U CN201720602021.XU CN201720602021U CN206783658U CN 206783658 U CN206783658 U CN 206783658U CN 201720602021 U CN201720602021 U CN 201720602021U CN 206783658 U CN206783658 U CN 206783658U
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- nutrient solution
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Abstract
Embodiment of the present utility model provides the cell expansion system with multiple separate units, is related to technical field of cell culture, is adapted to high-volume cell culture, and simple in construction, cell growth ambient stable.A kind of cell expansion system with multiple separate units, including nutrition liquid supplying device and cell reactor, the cell reactor is multiple, nutrition sap cavity and cell growth chamber are divided into by filter membrane in each cell reactor, the nutrition sap cavity offers nutrient input entrance and nutrient input outlet, the outlet of the nutrient input of the nutrient input entrance of the nutrition sap cavity and the nutrition sap cavity connects with the nutrition liquid supplying device, the nutrition liquid supplying device is set to form nutrient solution circulation canal with the nutrition sap cavity, nutrient solution circulating pump is provided with the nutrient solution circulation canal.The utility model is used for cell culture.
Description
Technical field
It the utility model is related to technical field of cell culture, more particularly to a kind of cell amplification with multiple separate units
System.
Background technology
Cell culture refers to all in vitro cultures, and its implication refers to take out tissue in driven thing or body, passes through machinery
Method or the method for enzymic digestion tissue is separated into unicellular, allow its specific conditions in vitro such as physiological environment in analogue body
Under carry out incubation culture, be allowed to survive and grow.In order that cell can smooth growth, often need detect cell cultivation process in
The growing environment of cell.
The mode of existing cell culture supplying nutrition liquid is generally：Cell is inoculated in reactor, then passes through conveying
Pipeline provides nutrient solution for its growth for cell or tissue.Compared to the mode being seeded in cell in culture dish, this culture side
Formula controls the input of fresh nutrient solution by detecting ambient parameter in real time, renewal, the more conducively growth of cell.
But in the requirement of some needs high-volume culture cells, for example, patient's cell culture is, it is necessary to shorter
The substantial amounts of patient's cell of culture in time, with for treating disease, and the scheme of prior art, if carrying out large batch of cell
Culture is, it is necessary to which using multiple reactors, corresponding each reactor needs to be supplied separately to nutrient solution, i.e. each reactor is corresponding
Connected with a nutrition liquid storage tank, so, one side structure is more complicated, space-consuming, on the other hand due to each nutrient solution
Nutrient solution in storage tank is due to storage time, the influence of environment, in fact it could happen that little bit different, easily causes thin in each reactor
There is difference in the state of intracellular growth, influences cell culture effect.
Utility model content
Embodiment of the present utility model provides a kind of cell expansion system with multiple separate units, is adapted to large quantities of
Measure cell culture, and simple in construction, cell growth ambient stable.
To reach above-mentioned purpose, embodiment of the present utility model adopts the following technical scheme that：
A kind of cell expansion system with multiple separate units, including nutrition liquid supplying device and cell reactor, institute
Cell reactor is stated to be multiple, nutrition sap cavity and cell growth chamber, institute are divided into by filter membrane in each cell reactor
State nutrition sap cavity and offer nutrient input entrance and nutrient input outlet, the nutrient input entrance of the nutrition sap cavity and the battalion
The nutrient input outlet of nutrient solution chamber connects with the nutrition liquid supplying device, makes the nutrition liquid supplying device and the nutrition
Sap cavity forms nutrient solution circulation canal, and nutrient solution circulating pump is provided with the nutrient solution circulation canal.
Further, the nutrient input entrance of the nutrition sap cavity of each cell reactor supplies with the nutrient solution
To being provided with the first valve between device.
Further, the nutrition liquid supplying device includes nutrition liquid storage tank and nutrient solution surge tank, and the nutrient solution delays
Rushing tank includes nutrient solution surge tank inlet and nutrient solution surge tank liquid outlet, and the nutrition liquid storage tank buffers with the nutrient solution
Tank inlet connects, and the nutrient input entrance of the nutrition sap cavity connects with the nutrient solution surge tank liquid outlet, the nutrition
The nutrient input outlet of sap cavity connects with the nutrient solution surge tank inlet, makes the nutrient solution surge tank and the nutrient solution
Chamber forms the nutrient solution circulation canal.
Further, the nutrition liquid storage tank is multiple that each nutrition liquid storage tank enters with the nutrient solution surge tank
Second valve is communicated between liquid mouth.
Further, the nutrient solution surge tank is provided with the gas outlet for being used for discharging waste gas.
Further, the nutrition liquid supplying device also includes gas dissolver, is provided with inside the gas dissolver
Hybrid chamber, the gas dissolver offer the gas dissolver inlet connected with the hybrid chamber, gas dissolver air inlet
Mouth and gas dissolver liquid outlet, the gas dissolver inlet connect with the nutrient solution surge tank liquid outlet, the gas
Body dissolvers air inlet is connected with source of the gas, and the nutrient input entrance of the gas dissolver liquid outlet and the nutrition sap cavity connects
It is logical.
Further, the source of the gas includes carbon dioxide air source and oxygen source, carbon dioxide air source and the oxygen gas
Source connects with the gas dissolver air inlet.
Further, the filter membrane is hollow fiber conduit, and the nutrition sap cavity is the inner space of the hollow fiber conduit,
The cell growth chamber is the exterior space of the hollow fiber conduit.
Further, the 3rd valve is provided with the nutrient solution circulation canal, inspection is provided with the nutrient solution circulation canal
Device is surveyed, the detection means is used to detect the index parameter of nutrient solution and cell in the nutrient solution circulation canal.
Preferably, the nutrient solution circulating pump is peristaltic pump.
The cell expansion system with multiple separate units that the utility model embodiment provides, including nutrient solution supply dress
Put and cell reactor.To adapt to high-volume cell culture, cell reactor is multiple, passes through filter membrane in each cell reactor
It is divided into nutrition sap cavity and cell growth chamber.Nutrition sap cavity offers nutrient input entrance and nutrient input outlet.Meanwhile nutrition
The nutrient input outlet of the nutrient input entrance and nutrition sap cavity of sap cavity connects with nutrition liquid supplying device, supplies nutrient solution
Device forms nutrient solution circulation canal with nutrition sap cavity.By the nutrient solution circulating pump set in nutrient solution circulation canal, can make
Nutrient solution is in nutrient solution circulation canal internal circulation flow.Nutrient solution can enter cell growth intracavitary by filter membrane, to be supplied to cell
To nutrition.Compared with prior art, by nutrient solution circulation canal constantly supplying nutrition liquid, the utilization rate of nutrient solution is improved.And
And nutrition liquid supplying device is connected with multiple cell reactors, also nutrition can be supplied into multiple cell reactors simultaneously
Liquid, to reach the purpose of high-volume cell culture, and it is relatively simple for structure, the cell growth environment in each reactor is steady
It is fixed, and then the state of cell growth is also than more consistent.
Brief description of the drawings
, below will be to embodiment in order to illustrate more clearly of the utility model embodiment or technical scheme of the prior art
Or the required accompanying drawing used is briefly described in description of the prior art.It should be evident that drawings in the following description are only
It is some embodiments of the utility model.For those of ordinary skill in the art, the premise of creative work is not being paid
Under, other accompanying drawings can also be obtained according to these accompanying drawings.
Fig. 1 is the structural representation of the cell expansion system with multiple separate units of the utility model embodiment；
Fig. 2 is the knot of the cell reactor of the cell expansion system with multiple separate units of the utility model embodiment
Structure schematic diagram；
Fig. 3 is to set gas dissolver in the cell expansion system with multiple separate units of the utility model embodiment
Structural representation.
Embodiment
Below in conjunction with the accompanying drawing in the utility model embodiment, the technical scheme in the embodiment of the utility model is carried out
Clearly and completely describe.Obviously, described embodiment is only the utility model part of the embodiment, rather than whole
Embodiment.Based on the embodiment in the utility model, those of ordinary skill in the art are not under the premise of creative work is made
The every other embodiment obtained, belong to the scope of the utility model protection.
In description of the present utility model, it is to be understood that term " " center ", " on ", " under ", "front", "rear",
The orientation or position relationship of the instruction such as "left", "right", " vertical ", " level ", " top ", " bottom ", " interior ", " outer " is based on accompanying drawing institutes
The orientation or position relationship shown, it is for only for ease of description the utility model and simplifies description, rather than indicates or imply and be signified
Device or element must have specific orientation, with specific azimuth configuration and operation, therefore it is not intended that to this practicality
New limitation.
Term " first ", " second " be only used for describe purpose, and it is not intended that instruction or imply relative importance or
The implicit quantity for indicating indicated technical characteristic.Thus, " first " is defined, the feature of " second " can be expressed or imply
Ground includes one or more this feature.In description of the present utility model, unless otherwise indicated, " multiple " are meant that two
Individual or two or more.
, it is necessary to which explanation, unless otherwise clearly defined and limited, term " are pacified in description of the present utility model
Dress ", " connected ", " connection " should be interpreted broadly, for example, it may be fixedly connected or be detachably connected, or integratedly
Connection；For the ordinary skill in the art, tool of the above-mentioned term in the utility model can be understood with concrete condition
Body implication.
Embodiment of the present utility model provides a kind of cell expansion system with multiple separate units, such as Fig. 1 and Fig. 2 institutes
Show, including nutrition liquid supplying device 1 and cell reactor 2, cell reactor 2 are multiple, pass through filter in each cell reactor 2
Film 21 is divided into nutrition sap cavity 22 and cell growth chamber 23, and nutrition sap cavity 22 offers nutrient input entrance 221 and nutrient input
Outlet 222, the nutrient input outlet 222 of the nutrient input entrance 221 and nutrition sap cavity 22 of nutrition sap cavity 22 supply with nutrient solution
Connected to device 1, nutrition liquid supplying device 1 and nutrition sap cavity 22 is formed nutrient solution circulation canal, in nutrient solution circulation canal
It is provided with nutrient solution circulating pump 3.
The cell expansion system with multiple separate units that the utility model embodiment provides, including nutrient solution supply dress
1 and cell reactor 2 are put, to adapt to high-volume cell culture, cell reactor 2 is multiple, is passed through in each cell reactor 2
Filter membrane 21 is divided into nutrition sap cavity 22 and cell growth chamber 23, and nutrition sap cavity 22 offers nutrient input entrance 221 and nutrient solution
Delivery outlet 222, meanwhile, the nutrient input outlet 222 of the nutrient input entrance 221 of nutrition sap cavity 22 and nutrition sap cavity 22 with battalion
Nutrient solution feedway 1 connects, and nutrition liquid supplying device 1 is formed nutrient solution circulation canal with nutrition sap cavity 22, passes through nutrient solution
The nutrient solution circulating pump 3 set in circulation canal, can be such that nutrient solution passes through in nutrient solution circulation canal internal circulation flow, nutrient solution
Filter membrane 21 can enter in cell growth chamber 23, to supply nutrition to cell.When compared with prior art, by nutrient solution circulation canal
When supplying nutrition liquid, improve the utilization rate of nutrient solution, moreover, nutrition liquid supplying device 1 is connected with multiple cell reactors 2,
Can the supplying nutrition liquid into multiple cell reactors 2 simultaneously, to reach the purpose for adapting to high-volume cell culture, and structure ratio
It is relatively simple, the cell growth ambient stable in each reactor 2, and then the state of cell growth is also than more consistent.
Can individually it be adjusted for convenience of to the supply of the nutrient solution of each cell reactor 2, as shown in figure 1, each
The first valve is provided between the nutrient input entrance 221 and nutrition liquid supplying device 1 of the nutrition sap cavity 22 of cell reactor 2
4.Each corresponding supply that nutrient solution is controlled by first valve 4 of cell reactor 2, and then individual cells can be directed to and reacted
Device 2 carries out the adjustment of nutrient solution supply.Meanwhile in the case of there is provided multiple cell reactors 2, for varying number requirement
Cell culture, the first valve 4 corresponding to the cell reactor 2 taken less than can be closed, to reduce energy consumption, economized on resources.
In general, nutrient solution often preserve under low-temperature condition, and the temperature that cell culture needs is higher, for example, fresh
Solution temperature is usually at 4 degrees Celsius, and cell culture apparatus temperature is usually 37 degrees Celsius, so, it is necessary to make nutrient solution
There is the process of a buffering, so that it heats up.Therefore, as shown in figure 1, nutrition liquid supplying device 1 includes the He of nutrition liquid storage tank 11
Nutrient solution surge tank 12, nutrient solution surge tank 12 include nutrient solution surge tank inlet 121 and nutrient solution surge tank liquid outlet
122, nutrition liquid storage tank 11 connects with nutrient solution surge tank inlet 121, the nutrient input entrance 221 of nutrition sap cavity 22 and nutrition
Liquid surge tank liquid outlet 122 connects, and the nutrient input outlet 222 of nutrition sap cavity 22 connects with nutrient solution surge tank inlet 121,
Nutrient solution surge tank 12 is set to form nutrient solution circulation canal with nutrition sap cavity 22.Nutrition liquid storage tank 11 is used for storing nutrient solution, seeks
Nutrient solution is first transported in nutrient solution surge tank 12 by nutrient solution storage tank 11 by nutrient solution surge tank inlet 121, buffers one section
Time, the temperature of nutrient solution is set to rise to normal temperature, then the battalion by nutrient solution surge tank liquid outlet 122 and nutrition sap cavity 22
Nutrient solution input port 221 is supplied to cell reactor.In addition, the nutrient input entrance 221 of nutrition sap cavity 22 buffers with nutrient solution
Tank liquid outlet 122 connects, and the nutrient input outlet 222 of nutrition sap cavity 22 connects with nutrient solution surge tank inlet 121, makes nutrition
Liquid surge tank 12 and nutrition sap cavity 22 form above-mentioned nutrient solution circulation canal, to improve the utilization rate of nutrient solution.
Generally, a variety of nutrient solutions are needed to be matched during cell culture, and cell is at different growth periods
The nutrient solution needed also has different demands, therefore, as shown in figure 1, nutrition liquid storage tank 11 is multiple, each nutrition liquid storage tank 11
Second valve 111 is communicated between nutrient solution surge tank inlet 121.Nutrition liquid storage tank 11 is multiple, Ke Yitong
When provide a variety of nutrient solutions to match, for example, salting liquid, general cell culture fluid, growth factor etc..Set valve can be right
How much the nutrient solution of each output of nutrition liquid storage tank 11 is controlled.
It should be noted that the amount that general growth factor needs is relatively fewer, thus can also use it is manually operated, directly
It is injected into syringe in cell growth chamber 23.In addition, the nutrient solution in nutrition liquid storage tank 11 can use pumped, such as
Shown in Fig. 1, nutrient solution rear pump 112 is provided between nutrition liquid storage tank 11 and nutrient solution surge tank 12.
Filter membrane 21 can prevent the inner cell of cell growth chamber 23 by the way that while the fresh battalion of nutrient solution chamber 22 can be made
Nutrient solution is entered in cell growth chamber 23.Meanwhile cell metabolism thing in cell growth chamber 23 and waste gas can enter to join the army
In nutrient solution chamber 23, and flowed back to by nutrient solution circulation canal in nutrient solution surge tank 12, nutrient solution surge tank 12 is in order to can arrange
Go out waste gas, the gas outlet 123 for being used for discharging waste gas is provided with nutrient solution surge tank 12.By gas outlet 123 can easily by
Waste gas is discharged.
Cell growth not only needs the supply of nutrient solution, it is also necessary to is passed through gas to be adjusted to nutrient solution.Such as oxygen
Gas gas and carbon dioxide, oxygen gas can adjust the dissolved oxygen amount in nutrient solution, and carbon dioxide can adjust battalion
The acid-base value of nutrient solution.In general, it can use and directly gas is passed through in cell reactor 2, still, the tune of such nutrient solution
Section process is slower.Therefore, in order to save the time of nutrient solution conditionses proportioning, as shown in figure 3, nutrition liquid supplying device 1 is also
Including gas dissolver 13.The inside of gas dissolver 13 is provided with hybrid chamber 131.Gas dissolver 13 offers and hybrid chamber 131
Gas dissolver inlet 132, gas dissolver air inlet 133 and the gas dissolver liquid outlet 134 of connection, gas dissolver
Inlet 132 connects with nutrient solution surge tank liquid outlet 122, and gas dissolver air inlet 133 is connected with source of the gas, gas dissolver
Liquid outlet 134 connects with the nutrient input entrance 221 of nutrition sap cavity 22.So, nutrient solution is first from gas dissolver inlet 132
Into in hybrid chamber 131, meanwhile, gas is entered in hybrid chamber 131 by gas dissolver air inlet 133, is filled in hybrid chamber 131
Tap is touched and mixed, and gas dissolves in liquid, nutrient solution is reached suitable acid-base value and dissolved oxygen amount, and then, nutrient solution passes through gas
The nutrient input entrance 221 of body dissolvers liquid outlet 134 and nutrition sap cavity 22 enters nutrition sap cavity 22.Compared to more directly by nutrition
Liquid and gas are passed through the mode in cell reactor 2, greatly increase gas and nutrient solution contact area, save gas consumption,
And control speed is faster.Moreover, the cell culture environment proportioning of nutrient solution is fulfiled ahead of schedule, nutrient solution conditionses proportioning can be saved
Time, the accurate acid-base value and dissolved oxygen amount for grasping nutrient solution, and then improve the data accuracy of cell growth or experiment.
It should be noted that as shown in figure 3, gas dissolver 13 is additionally provided with the gas dissolver connected with hybrid chamber 131
Exhaust outlet 135, to adjust the pressure in gas dissolver 13.Adjusted of course, it is possible to be set at gas dissolver exhaust outlet 135
Whole valve, pressure in gas dissolver 13 is accurately controlled by adjusting valve.
Source of the gas includes carbon dioxide air source and oxygen source, and carbon dioxide air source and oxygen source enter with gas dissolver
Gas port 133 connects.Source of the gas can be carbon dioxide and oxygen etc., wherein, carbon dioxide is used for adjusting the acid-base value of nutrient solution, oxygen
Gas is used for adjusting the dissolved oxygen amount of nutrient solution.
According to the functional characteristic of filter membrane 21, as shown in Fig. 2 filter membrane 21 is hollow fiber conduit, nutrition sap cavity 22 is hollow fibre
The inner space of pipe is tieed up, cell growth chamber 23 is the exterior space of hollow fiber conduit.
It should be noted that hollow fiber conduit can be a hollow fiber conduit or multiple hollow fiber conduits.Its
In, the interior or exterior space of multiple hollow fiber conduits compares the interior or exterior space of single hollow fiber conduit, and the area of contact surface is bigger, and then
Nutrient solution in nutrition sap cavity 22 can be contacted fully with the cell in cell growth chamber 23, and the exchange of nutrition is more efficient, because
This, is preferable to provide as multiple hollow fiber conduits.Likewise, the inside of gas dissolver 13 is it can also be provided that hollow fiber conduit,
To increase the contact area of nutrient solution and gas, the speed that gas dissolves in nutrient solution is improved.
The direction that nutrient solution in nutrition sap cavity 22 flows with the nutrient solution in cell growth chamber 23 is mainly by nutrition sap cavity
22 and cell growth chamber 23 in pressure control, when the pressure in nutrition sap cavity 22 is more than the pressure in cell growth chamber 23
When, the nutrient solution in nutrition sap cavity 22 is flowed into cell growth chamber 23, when the pressure in nutrition sap cavity 22 is less than cell growth chamber
During pressure in 23, metabolic thing and nutrient solution in cell growth chamber 23 enter in nutrition sap cavity 22.Nutrient solution circulation is logical
Pressure in road, the i.e. pressure of nutrient solution intracavitary can be adjusted by nutrient solution circulating pump 3, meanwhile, in order to aid in fast velocity modulation
Section, as shown in figure 1, being provided with the 3rd valve 5 in nutrient solution circulation canal, the 3rd valve is closed by the short time, nutrition can be made
Pressure in liquid circulation canal increases rapidly, the nutrient solution in nutrition sap cavity 22 is flowed into cell growth chamber 23, then, opens
3rd valve 5, realizes pressure release, opens nutrient solution circulation canal, and pressure declines, and realizes auxiliary quick regulation.Meanwhile in order to examine
The index parameter of nutrient solution and cell in nutrient solution circulation canal is surveyed, detection means 6, detection dress are provided with nutrient solution circulation canal
Put 6 to can be used for detecting the index parameter of nutrient solution and cell in nutrient solution circulation canal, for example, the acid-base value of nutrient solution, molten
Oxygen amount, temperature, the pressure in nutrient solution circulation canal and cell quantity etc..Detection means 6 shown in Fig. 1 is only labelled with
Pressure-detecting device and temperature-detecting device are illustrated in figure, it is necessary to explanation for the position of detection means 6, rather than detection
The whole of device 6, a variety of detection means can be set as needed, and be not limited to the pressure detecting shown in figure and temperature inspection
Survey, for example, acidity-basicity tester, dissolved oxygen amount detecting device and flow monitor etc..
In order to improve the efficiency that nutrient solution exchanges with the inner cell of cell growth chamber 23 in nutrition sap cavity 22, nutrient solution circulating pump
3 can be peristaltic pump.Peristaltic pump can make the nutrient solution in nutrient solution circulation canal produce stream of pulses, advantageously in raising filter membrane 21
Nutrient solution and the inner cell exchange efficiency of cell growth chamber 23 in the nutrition sap cavity 22 at place.
Specific embodiment of the present utility model is these are only, but the scope of protection of the utility model is not limited thereto,
Any those skilled in the art are in the technical scope that the utility model discloses, the change or replacement that can readily occur in,
It should all cover within the scope of protection of the utility model.Therefore, the scope of protection of the utility model should be with the guarantor of claim
Shield scope is defined.
Claims (10)
1. a kind of cell expansion system with multiple separate units, it is characterised in that including nutrition liquid supplying device and cell
Reactor, the cell reactor are multiple, and nutrition sap cavity and cell are divided into by filter membrane in each cell reactor
Growth chamber, the nutrition sap cavity offer nutrient input entrance and nutrient input outlet, the nutrient infusion of the nutrition sap cavity
The outlet of the nutrient input of mouth and the nutrition sap cavity connects with the nutrition liquid supplying device, makes the nutrition liquid supplying device
Nutrient solution circulation canal is formed with the nutrition sap cavity, nutrient solution circulating pump is provided with the nutrient solution circulation canal.
2. cell expansion system according to claim 1, it is characterised in that the nutrition of each cell reactor
The first valve is provided between the nutrient input entrance of sap cavity and the nutrition liquid supplying device.
3. cell expansion system according to claim 1, it is characterised in that the nutrition liquid supplying device includes nutrient solution
Storage tank and nutrient solution surge tank, the nutrient solution surge tank includes nutrient solution surge tank inlet and nutrient solution surge tank goes out liquid
Mouthful, the nutrition liquid storage tank connects with the nutrient solution surge tank inlet, the nutrient input entrance of the nutrition sap cavity and institute
The connection of nutrient solution surge tank liquid outlet is stated, nutrient input outlet and the nutrient solution surge tank inlet of the nutrition sap cavity connect
It is logical, the nutrient solution surge tank is formed the nutrient solution circulation canal with the nutrition sap cavity.
4. cell expansion system according to claim 3, it is characterised in that the nutrition liquid storage tank is multiple, Mei Gesuo
State and second valve is communicated between nutrition liquid storage tank and the nutrient solution surge tank inlet.
5. cell expansion system according to claim 3, it is characterised in that the nutrient solution surge tank, which is provided with, to be used to discharge
The gas outlet of waste gas.
6. the cell expansion system according to any one of claim 3~5, it is characterised in that the nutrient solution supply dress
Putting also includes gas dissolver, and hybrid chamber is provided with inside the gas dissolver, and the gas dissolver offers to be mixed with described
Close gas dissolver inlet, gas dissolver air inlet and the gas dissolver liquid outlet of chamber connection, the gas dissolver
Inlet connects with the nutrient solution surge tank liquid outlet, and the gas dissolver air inlet is connected with source of the gas, and the gas is molten
Solution device liquid outlet connects with the nutrient input entrance of the nutrition sap cavity.
7. cell expansion system according to claim 6, it is characterised in that the source of the gas includes carbon dioxide air source and oxygen
Gas source of the gas, the carbon dioxide air source and oxygen source connect with the gas dissolver air inlet.
8. cell expansion system according to claim 1, it is characterised in that the filter membrane is hollow fiber conduit, the battalion
Nutrient solution chamber is the inner space of the hollow fiber conduit, and the cell growth chamber is the exterior space of the hollow fiber conduit.
9. cell expansion system according to claim 1, it is characterised in that the 3rd is provided with the nutrient solution circulation canal
Valve, the nutrient solution circulation canal is interior to be provided with detection means, and the detection means is used to detect the nutrient solution circulation canal
The index parameter of interior nutrient solution and cell.
10. cell expansion system according to claim 1, it is characterised in that the nutrient solution circulating pump is peristaltic pump.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201720602021.XU CN206783658U (en) | 2017-05-26 | 2017-05-26 | A kind of cell expansion system with multiple separate units |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201720602021.XU CN206783658U (en) | 2017-05-26 | 2017-05-26 | A kind of cell expansion system with multiple separate units |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109943528A (en) * | 2019-04-19 | 2019-06-28 | 华子昂 | The method that T cell is produced in enormous quantities |
| WO2021114129A1 (en) * | 2019-12-11 | 2021-06-17 | 中国科学院深圳先进技术研究院 | In vitro experimental model for research of mechanism of tumor perineural invasion |
-
2017
- 2017-05-26 CN CN201720602021.XU patent/CN206783658U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109943528A (en) * | 2019-04-19 | 2019-06-28 | 华子昂 | The method that T cell is produced in enormous quantities |
| WO2021114129A1 (en) * | 2019-12-11 | 2021-06-17 | 中国科学院深圳先进技术研究院 | In vitro experimental model for research of mechanism of tumor perineural invasion |
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