CN206408246U - A kind of reactor for producing L Terleus - Google Patents
A kind of reactor for producing L Terleus Download PDFInfo
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- CN206408246U CN206408246U CN201720036905.3U CN201720036905U CN206408246U CN 206408246 U CN206408246 U CN 206408246U CN 201720036905 U CN201720036905 U CN 201720036905U CN 206408246 U CN206408246 U CN 206408246U
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- leucine
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- kettle
- type filter
- producing
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Abstract
The utility model discloses a kind of reactor for producing L Terleus, autoclave body bottom is vertically arranged with L Terleu delivery pipes, L Terleu delivery pipes lower end is stretched out outside kettle through kettle bottom wall, upper end is connected with horizontally disposed L Terleus bleeder, L Terleu bleeders both sides are provided with some L-type filter sticks, L-type filter stick is hollow, surface distributed has some apertures, the diameter of the aperture is less than the diameter of immobilised enzymes, the oxygen inlet pipe that one end is inserted into the inner, the other end and O are provided with L Terleu delivery pipes2Compressor is connected, and regulating valve is provided with oxygen inlet pipe, and oxygen inlet pipe stretches into the connection of one end in L Terleu delivery pipes nozzle, and the jet direction of the nozzle is upward.L-type filter stick in this reactor had both had the effect of separation of solid and liquid, and the effect of specific uniform oxygen, while the separation of feed liquid and immobilised enzymes is realized, also accelerates immobilized enzyme catalysis efficiency, improves yield.
Description
Technical field
The utility model is related to a kind of reactor for producing S-Leucine.
Background technology
S-Leucine is the important centre of the atazanavir of the anti-hepatitis new drug VX-960 of synthesis and HIV first-line treatments
Body, the development to physianthropy is extremely important, thus it is possible to fast and effectively synthesis S-Leucine have it is high
Requirement.It is in immobilised enzymes during existing production S-Leucine（Immobilised enzymes LeuDH leucine dehydrogenases and NAD oxidized forms
Cozymase）Catalytic action under, by ammonium formate and trimethyl conversion of pyruvate S-Leucine, utilize current reactor production L-
After during Terleu, not only immobilized enzyme catalysis efficiency is low, and reaction terminates, because also containing immobilised enzymes in reaction solution, need
Put into again in reactor after reaction solution is carried out into suction filtration, then carry out concentration recrystallization, this is cumbersome, expend the time.
Utility model content
The utility model provides a kind of reactor for producing S-Leucine, is realizing point of feed liquid and immobilised enzymes
From while, accelerate enzymatic efficiency, improve yield.
In order to solve the above problems, the technical solution adopted in the present invention is a kind of such, S-Leucine of producing
Reactor, which includes being provided with kettle, kettle at the top of agitator, kettle, offers material inlet and ammonia import, and autoclave body bottom is erected
Straight to be provided with S-Leucine delivery pipe, the lower end of described S-Leucine delivery pipe is stretched out outside kettle through kettle bottom wall,
The upper end of S-Leucine delivery pipe is connected with horizontally disposed S-Leucine bleeder, described S-Leucine row
Put branch pipe both sides and be provided with some L-type filter sticks being connected with S-Leucine bleeder, during described L-type filter stick is
Empty, surface distributed has some apertures, and the diameter of the aperture is less than the diameter of immobilised enzymes, described S-Leucine delivery pipe
Inside it is additionally provided with the oxygen inlet pipe that one end is inserted into the inner, the other end and O of oxygen inlet pipe2Compressor is connected, and is set on oxygen inlet pipe
Regulating valve is equipped with, oxygen inlet pipe stretches into the connection of one end in S-Leucine delivery pipe nozzle, and the jet direction of the nozzle is upward.
Preferably, set in the kettle outside temperature sensor, kettle and be cased with heating mantle, temperature sensor passes through controller
It is connected with heating mantle.
Preferably, a diameter of 5-75 microns of the aperture on L-type filter stick surface.
Preferably, the vertical kettle length of L-type filter stick is 30-90 centimetres, is made up of stainless steel material.Described L-type
Filter stick is symmetricly set on S-Leucine bleeder both sides two-by-two.
Beneficial effect：When the 1st, carrying out S-Leucine production using the utility model, oxygen is filtered by oxygen inlet pipe through L-type
Rod is distributed in reactor, it is ensured that the uniform gas distribution of whole reactor, oxygen contacts more uniform with immobilised enzymes, accelerates enzyme
Catalytic efficiency, so that S-Leucine high income, up to 90-95%；Reacted feed liquid is entered by aperture on L-type filter stick
Enter after S-Leucine bleeder, discharged by S-Leucine delivery pipe, and immobilised enzymes is more than L-type filter stick table because of diameter
The diameter of face aperture and be delayed in reactor, be directly used in down applying mechanically for batch S-Leucine production, effectively protect solid
Surely change the activity of enzyme, reduce the loss of immobilised enzymes；Thus, the L-type filter stick in this reactor had both had the work of separation of solid and liquid
With, and the effect of specific uniform oxygen, while the separation of feed liquid and immobilised enzymes is realized, also accelerate immobilized enzyme catalysis
Efficiency, improves the yield of S-Leucine.
The 2nd, oxygen inlet pipe, the also effect with cleaning L-type filter stick are set in S-Leucine delivery pipe, it is to avoid L
The obstruction of type filter stick surface aperture, improves the filter efficiency of L-type filter stick.
Brief description of the drawings
Fig. 1 is the utility model structural representation.
Embodiment
In order to deepen to understand of the present utility model, further is made to the utility model below in conjunction with embodiment and accompanying drawing
It is described in detail, the embodiment is only used for explaining the utility model, does not constitute the restriction to the utility model protection domain.
Referring to Fig. 1, a kind of reactor for producing S-Leucine, including kettle 1, kettle is interior to set agitator 3, kettle top
Portion offers material inlet 4 and ammonia import 5, and autoclave body bottom is vertically arranged with S-Leucine delivery pipe 6, and described L- is tertiary bright
The lower end of propylhomoserin delivery pipe 6 is stretched out outside kettle through kettle bottom wall, the upper end of S-Leucine delivery pipe 6 and horizontally disposed L-
Terleu bleeder 7 is connected, and the described both sides of S-Leucine bleeder 7 are symmetrically arranged with arranges with S-Leucine
Some L-type filter sticks 8 that branch pipe is connected are put, described L-type filter stick 8 is hollow, and surface distributed there are some apertures, and this is small
A diameter of 5-75 microns of hole, are additionally provided with one end less than the diameter of immobilised enzymes, in described S-Leucine delivery pipe 6 and stretch
Enter the oxygen inlet pipe 9 in it, the other end and O of oxygen inlet pipe 92Compressor 10 is connected, and regulating valve is provided with oxygen inlet pipe 9
11, oxygen inlet pipe stretches into the connection of one end in S-Leucine delivery pipe nozzle 12, and the jet direction of the nozzle 12 is upward.
Preferably, set in the kettle outside temperature sensor 2, kettle and be cased with heating mantle（Not shown in Fig. 1）, temperature biography
Sensor is connected by controller with heating mantle.
L-type filter stick 8 is made up of stainless steel material, depending on the size of its number and length according to reactor, General reactions
Kettle is bigger, and the number of L-type filter stick is more, and length is longer, it is preferable that L-type filter stick is 6, and vertical portion length is 30-90
Centimetre.
Ammonium formate and water are added into reactor from material inlet 4, material is stirred after dissolving by agitator 3,
Trimethyl pyruvic acid is added by material inlet 4, ammonia is passed through into reactor by ammonia import 5, regulation pH to 7 is stirred continuously
Stop being passed through for ammonia afterwards, detect that reactor temperature is 25 DEG C by temperature sensor 2, immobilization is added by material inlet 4
Enzyme（Immobilised enzymes LeuDH leucine dehydrogenases and NAD oxidized coenzymes I）, while oxygen is passed through by oxygen inlet pipe 9, through L-type mistake
The aperture on the surface of filter stick 8 goes out, and into reactor, an aerobic environment is provided for enzymic catalytic reaction, whole course of reaction passes through temperature
Spend sensor 2 to monitor after temperature in real time, heating mantle is controlled by controller, makes the temperature stabilization in reactor in 25 DEG C, instead
Answer after 2h, stop being passed through for oxygen, nitrogen is passed through into reactor by ammonia import 5, application pressure is carried out to reaction solution, made
Material enters S-Leucine bleeder 7 by the aperture on the surface of L-type filter stick 8, then by the row of S-Leucine delivery pipe 6
Go out, then concentrated crystallization obtains S-Leucine, and immobilised enzymes because diameter is more than the diameter of L-type filter stick surface aperture and by
Detention is directly used in down applying mechanically for batch S-Leucine production in reactor.
Preferred embodiment of the present utility model is the foregoing is only, it is all at this not to limit the utility model
Within the spirit and principle of utility model, any modification, equivalent substitution and improvements made etc. should be included in the utility model
Protection domain within.
Claims (6)
1. a kind of reactor for producing S-Leucine, it is characterised in that including kettle, is provided with agitator, kettle in kettle
Top offers material inlet and ammonia import, and autoclave body bottom is vertically arranged with S-Leucine delivery pipe, and described L- is tertiary bright
The lower end of propylhomoserin delivery pipe is stretched out outside kettle through kettle bottom wall, the upper end of S-Leucine delivery pipe and horizontally disposed uncle L-
Leucine bleeder is connected, and described S-Leucine bleeder both sides are provided with and S-Leucine bleeder phase
Some L-type filter sticks of connection, described L-type filter stick is hollow, and surface distributed has some apertures, and the diameter of the aperture is small
In being additionally provided with the oxygen inlet pipe that one end is inserted into the inner, oxygen in the diameter of immobilised enzymes, described S-Leucine delivery pipe
The other end and O of inlet pipe2Compressor is connected, and regulating valve is provided with oxygen inlet pipe, and oxygen inlet pipe stretches into S-Leucine discharge
One end connection nozzle in pipe, the jet direction of the nozzle is upward.
2. a kind of reactor for producing S-Leucine according to claim 1, it is characterised in that set in the kettle
Heating mantle is cased with outside temperature sensor, kettle, temperature sensor is connected by controller with heating mantle.
3. a kind of reactor for producing S-Leucine according to claim 1, it is characterised in that L-type filter stick surface
A diameter of 5-75 microns of aperture.
4. a kind of reactor for producing S-Leucine according to claim 1, it is characterised in that L-type filter stick it is perpendicular
Straight partial-length is 30-90 centimetres.
5. a kind of reactor for producing S-Leucine according to claim 1, it is characterised in that L-type filter stick is not by
Rust Steel material is made.
6. a kind of reactor for producing S-Leucine according to claim 1, it is characterised in that described L-type filtering
Rod is symmetricly set on S-Leucine bleeder both sides two-by-two.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720036905.3U CN206408246U (en) | 2017-01-12 | 2017-01-12 | A kind of reactor for producing L Terleus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720036905.3U CN206408246U (en) | 2017-01-12 | 2017-01-12 | A kind of reactor for producing L Terleus |
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| Publication Number | Publication Date |
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| CN206408246U true CN206408246U (en) | 2017-08-15 |
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| CN201720036905.3U Active CN206408246U (en) | 2017-01-12 | 2017-01-12 | A kind of reactor for producing L Terleus |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107974404A (en) * | 2017-10-31 | 2018-05-01 | 湖北凌晟药业有限公司 | Enzyme digestion reaction kettle |
-
2017
- 2017-01-12 CN CN201720036905.3U patent/CN206408246U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107974404A (en) * | 2017-10-31 | 2018-05-01 | 湖北凌晟药业有限公司 | Enzyme digestion reaction kettle |
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