CN206248539U - Quantitative analysis instrument - Google Patents

Abstract

Switching Power Supply, circuit control system, optical sensing devices, colorimetric pool, LCDs, 4 × 4 matrix keyboards, mini-printer, the communication modules of RS 232 are provided with the utility model discloses a kind of quantitative analysis instrument, including housing, in housing；Circuit control system includes data acquisition module, Switching Power Supply, display device, the communication modules of RS 232 that control module is connected with control module；Optical sensing devices include being arranged on light source radiating circuit plate, the light source circuit board for receiving of colorimetric pool side；Colorimetric pool is cuboid solid construction, and middle part is provided with three cuvette grooves, three apertures are had positioned at the corresponding two sides of test tube trench bottom, and colorimetric pool is covered on housing upper surface；LCDs, 4 × 4 matrix keyboards, mini-printer, Switching Power Supply, the communication modules of RS 232 are connected with MCU.The utility model is easy to operate quick, and the degree of accuracy is high, and sensitivity is high, the reproducible and linear wide ranges of detection.

Description

Quantitative analysis instrument

Technical field

The utility model is related to medical detecting Instrument field, more particularly to a kind of quantitative analysis instrument.

Background technology

Urinalysis is one of clinical the most frequently used laboratory indexes, diagnosis not only to disease in the urological system, observation of curative effect Reference is provided, and it is also helpful to the diagnosis of every other systemic diseases that blood biochemical component can be caused to change.Additionally, Urinalysis can be also used for safe medication detection and health status preliminary assessment.

For traditional approach, uroscopy is often anti-with urine sample Biochemical Components according to reagent area in test strips Color change that should be produced, it is UBG in qualitative or quantitative detection urine specimen, bilirubin, ketoboidies, blood, protein, white thin The content of born of the same parents, vitamin C (or micro- albumin) etc. and proportion, the acid-base value of urine sample etc..The content of iodine turns into detection urine The focus of modern's common concern, so as to reflect different regions, different crowd to the demand and the general level of the health of iodine.

Now, Urine Analyzer product market welcomes fast-developing period, it is already possible to carry out the detection of multiple projects.But The key component of Urine Analyzer is optical system, and its principle is that light is irradiated into urine sample reaction zone to produce reflected light, instead The intensity for penetrating light is relevant with the reaction color of each test event, is contained by various materials in the situation analysis urine of reflected light Amount.Existing Urine Analyzer is substantially manually operated light source irradiates urine sample, spotlight effect difference and operating procedure is complicated, accurate Exactness is low, but uses the high accuracy usual apparatus expensive of urine detection instrument, complex structure, it is impossible to meet the therapeutic machine of each level Structure detection demand, therefore a kind of offer new quantitative analysis instrument is provided badly solves the above problems.

Utility model content

Technical problem to be solved in the utility model is to provide a kind of quantitative analysis instrument, and easy to operate, analyze speed is fast.

In order to solve the above technical problems, the technical scheme that the utility model is used is：A kind of quantitative analysis instrument is provided, Circuit control system, colorimetric pool, optical sensing devices, mini-printer are provided with including housing, in housing；

Circuit control system includes data acquisition module, Switching Power Supply, the display dress that control module is connected with control module Put, RS-232 communication modules, data acquisition module include light source launch driving circuit and light source launch driving circuit output end phase The light source that light source radiating circuit even, light source receiving circuit are connected with light source receiving circuit output end receives amplifying circuit, light source The output end that the input of radiating circuit, light source receive amplifying circuit is connected with control module, mini-printer with control mould Block is connected；Optical sensing devices include being arranged on light source radiating circuit plate, the light source circuit board for receiving of colorimetric pool side；

Colorimetric pool is cuboid solid construction, and top is provided with colorimetric pool lid, and middle part is provided with three equidistant cuvette grooves, is located at The corresponding two sides of test tube trench bottom have three apertures.

In one preferred embodiment of the utility model, control module includes MCU.

Further, MCU uses STM32F103VBT6 single-chip microcomputers, and it is internal including AD conversion module, can connect light source The voltage signal of the big circuit output of folding and unfolding carries out analog-to-digital conversion, and then data are calculated, and draws the testing result of sample.

In one preferred embodiment of the utility model, display device includes being arranged on the liquid crystal display of housing upper surface Screen, 4 × 4 matrix keyboards.

In one preferred embodiment of the utility model, the light source that light source radiating circuit is used for needed for launching detection, its bag Three LEDs -1, LED-2, LED-3 on light source radiating circuit plate are included, light source receiving circuit is used to receive By in test tube detect solution absorb after light source, it include be located at light source circuit board for receiving on three silicon photocell T1- T3。

In one preferred embodiment of the utility model, light source launch driving circuit is used to drive light source radiating circuit to launch Light source, it includes triode Q2, Q3, Q5, resistance R42-R44, potentiometer R26-R28, resistance R42-R44 respectively with three poles The base stage of pipe Q2, Q3, Q5 is connected, and potentiometer R26-colelctor electrodes of the R28 respectively with triode Q2, Q3, Q5 is connected, triode Q2, The emitter stage of Q3, Q5 is connected with three LEDs -1, LED-2, LED-3 respectively.

In one preferred embodiment of the utility model, light source receives amplifying circuit is used for export light source receiving circuit Current signal is changed and amplified, and it includes three operational amplifier CA3140 and peripheral circuit, and input is pin OPTI_ IN_0, OPTI_IN_1, OPTI_IN_2, are connected with light source receiving circuit, and output end is connected to control module.

In one preferred embodiment of the utility model, the bottom of colorimetric pool lid is provided with the waist type groove of sealing test tube mouthful, makes Test tube equipped with urine specimen to be measured is placed in a closed lighttight space.

Further, the material of colorimetric pool is black light-proof material, makes urine specimen to be measured closed impermeable in one The reaction environment of light.

In one preferred embodiment of the utility model, shell back face-plate be provided with the switch that is connected with Switching Power Supply by Key, power interface, fuse, RS-232 serial ports, the side of housing are provided with ventilating opening, are easy to radiating.

The beneficial effects of the utility model are：The utility model simple structure, low cost, by setting colorimetric pool and to light The ingehious design of sensing device is learned, the content of iodine of urine can be rapidly and precisely detected, easy to operate, the degree of accuracy is high, sensitivity Height, the reproducible and linear wide ranges of detection, it is adaptable to which medical institutions' detection of each level is used.

Brief description of the drawings

Fig. 1 is one of dimensional structure diagram of the preferred embodiment of the utility model quantitative analysis instrument one；

Fig. 2 is the two of the dimensional structure diagram of the preferred embodiment of the utility model quantitative analysis instrument one；

Fig. 3 is the internal structure schematic diagram of the quantitative analysis instrument；

Fig. 4 is the structural representation of the colorimetric pool；

Fig. 5 is the profile of the colorimetric pool；

Fig. 6 is the structural representation of the colorimetric pool lid；

Fig. 7 is the theory diagram of the quantitative analysis instrument；

Fig. 8 is the circuit frame figure of the quantitative analysis instrument；

Fig. 9 is the circuit theory diagrams of the Switching Power Supply；

Figure 10 is the circuit theory diagrams of the control module；

Figure 11 is the circuit theory diagrams of the light source radiating circuit；

Figure 12 is the circuit theory diagrams of the light source launch driving circuit；

Figure 13 is the circuit theory diagrams of the light source receiving circuit；

Figure 14 is the circuit theory diagrams that the light source receives amplifying circuit；

Figure 15 is the circuit theory diagrams of the RS-232 communication modules.

The mark of each part is as follows in accompanying drawing：1st, housing, 2, circuit control system, 3, colorimetric pool, 31, cuvette groove, 32, small Hole, 33, colorimetric pool lid, 34, waist type groove, 4, mini-printer, 5, LCDs, 6,4 × 4 matrix keyboards, 7, switch key, 8th, power interface, 9, fuse, 10, RS-232 serial ports, 11, ventilating opening, 12, light source radiating circuit plate, 13, light source receiving circuit Plate, 14, Switching Power Supply.

Specific embodiment

Preferred embodiment of the present utility model is described in detail below in conjunction with the accompanying drawings, so that advantage of the present utility model Can be easier to be readily appreciated by one skilled in the art with feature, it is apparent clear and definite so as to be made to protection domain of the present utility model Define.

Fig. 1 to Fig. 3 is referred to, the utility model embodiment includes：

A kind of quantitative analysis instrument, is provided with circuit control system 2, colorimetric pool 3, optical sensing devices, microprinting in housing Machine 4.Circuit control system 2 includes data acquisition module, Switching Power Supply 14, the display dress that control module is connected with control module Put, RS-232 communication modules；Control module includes MCU, and data acquisition module includes that light source launch driving circuit and light source are launched The light source that the connected light source radiating circuit of drive circuit output end, light source receiving circuit are connected with light source receiving circuit output end Amplifying circuit is received, the output end that the input of light source radiating circuit, light source receive amplifying circuit is connected with control module.Shell The upper surface of body 1 is provided with colorimetric pool lid 33, the LPT of mini-printer 4；The rear board of housing 1 is provided with and is connected with Switching Power Supply 14 Switch key 7, power interface 8, fuse 9, the side of housing 1 is provided with ventilating opening 11, is easy to radiating.

Optical sensing devices include light source radiating circuit plate 12, light source circuit board for receiving 13, and two pieces of circuit boards pass through screw The side of colorimetric pool 3 is fixed on, light source radiating circuit plate 12 is provided with light source radiating circuit, and light source radiating circuit is used to launch to be examined Light source needed for surveying, it includes three LEDs -1, LED-2, LED-3, and light source circuit board for receiving 13 is provided with light source Receiving circuit, light source receiving circuit is used to receive the light source after detecting solution absorption in test tube, and it includes that three photoelectricity connect Receive device, it is preferred that photelectric receiver uses silicon photocell 2DU3.

With reference to Fig. 4 and Fig. 5, colorimetric pool 3 is cuboid solid construction, and middle part is provided with three equidistant cuvette grooves 31, is used for The test tube equipped with urine specimen to be measured is placed, corresponding two sides have three apertures 32 positioned at the bottom of cuvette groove 31, Thus the quantitative analysis instrument is provided with three sense channels, can simultaneously detect three urine specimens.One side is used to place light source Light emitting diode on radiating circuit plate 12, another side is used to place the photelectric receiver on light source circuit board for receiving 13, hair After the illumination of optical diode transmitting is mapped to test tube, launching light is directly received by photelectric receiver, and spotlight effect is good, accuracy of detection It is high.The material of colorimetric pool 3 is black light-proof material, while the bottom of colorimetric pool lid 33 is provided with the waist type groove of sealing test tube mouthful 34, as shown in fig. 6, making urine specimen to be measured be in a closed lighttight reaction environment.

Display device includes being arranged on LCDs 5,4 × 4 matrix keyboards 6 of the upper surface of housing 1, RS-232 communication moulds Block includes being arranged on the RS-232 serial ports 10 of the rear board of housing 1, can be communicated with computer.

Refer to Fig. 7, the input of the output end concatenation operation amplifier of photelectric receiver, operational amplifier, wave filter, AD conversion module, MCU are sequentially connected, LCDs 5,4 × 4 matrix keyboards 6, mini-printer 4, Switching Power Supply 14, RS- 232 communication modules are connected with MCU.MCU uses 32 ARM microcontroller STM32F103, and internal resource enriches, used as circuit The control core of control system.After the light that light emitting diode sends absorbs through the solution in test tube in colorimetric pool 3, the light of reflection Received by photelectric receiver and be converted to electric signal, electric signal carries out signal amplification through operational amplifier, after wave filter is to amplification Received by converter after electric signal filtering process, MCU is sent to after carrying out analog-to-digital conversion by AD conversion module.

Specifically describe the circuit structure and principle of each module in the circuit control system 2 respectively with reference to Fig. 8：

Fig. 9 is referred to, the input of the Switching Power Supply 14 is 220V alternating currents, respectively through fuse, switch, transformation For whole system provides 12V, 5V voltage after device, rectifier bridge, filter unit, Voltage stabilizing module, the voltage stabilizing of 5V voltages is 3.3V direct currents The mainboard of supply circuit control system.

Figure 10 is referred to, the MCU uses the STM32F103VBT6 model single-chip microcomputers of ST companies, and the single-chip microcomputer is by string Mouth communication module, IO input/output modules, AD conversion module reads the operation information of matrix keyboard, control transmitting light source and sets Launching light light intensity, reception change and calculate data, the control LCDs display final result and right for receiving light source and setting The parameter setting information of equipment, controls RS-232 communicating circuits to control printer to print testing result and control detection to tie Fruit uploads computer end Software of Data Statistics.It include drive light source radiating circuit send light source controlling switch LED_CON_0, LED_CON_1, LED_CON_2, CA3140 amplify input pin A_SIGN_IN_0, A_SIGN_IN_1, A_ of conversion signal SIGN_IN_2, the input pin ROW_0 of matrix keyboard signal, ROW_1, ROW_2, ROW_3, LINE_0, LINE_1, LINE_2, LINE_3, input pin UART_1_TX, UART_1_RX of printer signal, upload the input pin UART_ of computer client information 4_TX, UART_4_RX, the input pin LCD_DB0-LCD_DB7 of LCDs control signal, LCD_RST, LCD_INT, LCD_RS、LCD_RW、LCD_RD、LCD_CS1、LCD_CS2、LCD_BSY。

Figure 11 is referred to, the light source radiating circuit is using three LEDs -1, LED-2, LED-3 as light Source transmitter, three light source emitters LED-1, LED-2, LED-3 are turned on by LED in the control I/O port on JP2 and MCU respectively Connected with closing control signal pin LED_CON_0, LED_CON_1, LED_CON_2.Refer to Figure 12, light source launch driving circuit For drive light source radiating circuit launch light source, it include triode Q2, Q3, Q5, resistance R42-R44, potentiometer R26- R28, the annexation of each circuit components as shown in figure 12, resistance R42-R44 respectively with the base stage phase of triode Q2, Q3, Q5 Even, potentiometer R26-colelctor electrodes of the R28 respectively with triode Q2, Q3, Q5 is connected, the emitter stage difference of triode Q2, Q3, Q5 It is connected with three LEDs -1, LED-2, LED-3.MCU is respectively by controlling LED_CON_0, LED_CON_1, LED_ Tri- pins of CON_2 control three Push And Releases of light emitting source, then by adjust the resistance size of potentiometer R26, R27, R28 come Adjust by the size of current of light emitting source, so as to change the brightness of light emitting source, amplified electric signal by triode Q2, Q3, Q5 Three LEDs -1, LED-2, LED-3 are driven afterwards.Three light source emitters LED-1, LED-2, LED-3 send 630nm light, through detected sample after irradiate respectively in corresponding light source receiving circuit in fig. 13.

Figure 13 is referred to, the light source receiving circuit uses three silicon photocell T1-T3 as light source receiver, three Silicon photocell T1-T3 receives OPTI_IN_0, OPTI_IN_1, OPTI_ in amplifying circuit by JP1 with the light source respectively Tri- pins of IN_2 are connected.Silicon photocell 2DU3 can export the electric current of positive correlation size, the electricity of output according to the light intensity for receiving Stream receives tri- pins of OPTI_IN_0, OPTI_IN_1, OPTI_IN_2 in amplifying circuit and is connected by JP1 with the light source. Figure 14 is referred to, the light source receives amplifying circuit is used to that the current signal that light source receiving circuit is exported to be changed and put Greatly, it includes three operational amplifier CA3140 and peripheral circuit, and the annexation of each circuit components as shown in figure 14, is input into It is pin OPTI_IN_0, OPTI_IN_1, OPTI_IN_2 to hold, and output end is connected to pin A_SIGN_IN_0, A_ of MCU SIGN_IN_1, A_SIGN_IN_2, wherein diode D4 are connected between A_SIGN_IN_1 and 3.3V, D7 is connected to GND and A_ Between SIGN_IN_1, D4 and connected mode effect as D7 be limit the output voltage of operational amplifier CA3140 0- Between 3.3V, pin A_SIGN_IN_0, A_SIGN_IN_1, A_SIGN_IN_2 to MCU shield, diode D5 with The effect of D8, D6 and D9 is similarly.Because the signal of 2DU3 is very faint, belong to a milliampere level currents, by operational amplifier The current signal of the 2DU3 outputs that CA3140 and peripheral circuit will be received is transformed into voltage signal and amplifies simultaneously, then by A_ Tri- pins of SIGN_IN_0, A_SIGN_IN_1, A_SIGN_IN_2 are transmitted into MCU, by the AD conversion module inside MCU Signal to CA3140 outputs carries out analog-to-digital conversion, and then data are calculated, and draws the testing result of sample.

Figure 15 is referred to, the RS-232 communication modules include electrical level transferring chip MAX3232 and peripheral circuit, each circuit As shown in figure 15, input UART_1_RX, UART_1_TX, UART_4_RX, UART_4_TX distinguish the annexation of component It is connected with the corresponding pin of MCU, output end RS232_RX, RS232_TX is connected with printer, RS232_1_RX, RS232_1_TX It is connected with external computer end.Quantitative analysis instrument changes electricity after MCU internal calculations draw testing result through chip MAX3232 After flat, printer be sent to by RS232_RX, RS232_TX and print testing result, by RS232_1_RX, RS232_1_TX Testing result is sent into computer end software to be stored.

The operation principle of the quantitative analysis instrument is using Quantitative colorimetric method principle, the urine specimen that will be pre-processed and develop the color After being put into the instrument, by the use of light emitting diode as light source launch specific wavelength light, through colorimetric pool 3 after, to 635nm wavelength Light produce absorption, degree of absorption according to light calculates corresponding detectable concentration, and absorbance is with sample concentration under certain condition It is linear.

Urine iodine concentration is calculated as follows：

C1=A1/A2 × C2

Wherein：C1-urine iodine concentration；

A1-urine absorbance；

A2-titer absorbance；

C2-concentration of standard solution.

The utility model simple structure, low cost, by setting colorimetric pool and the ingehious design to optical sensing devices, can The content of iodine of urine is rapidly and precisely detected, easy to operate, the degree of accuracy is high, and sensitivity is high, the reproducible and linear model of detection Enclose width.

The quantitative analysis instrument is only used for vitro detection, is widely used in central laboratory, the door/emergency treatment of medical institutions Room, clinical department and other medical services point (such as community medicine point), MECs are tested, R＆D units inspection is also applied for Survey.Its correlated performance is as follows：

1) to absorbance≤0.04 of blank reagent；

2) the detection range of linearity is (50~500) μ g/L, equation of linear regression correlation coefficient r >=0.990；

3) relative deviation≤15% of degree of accuracy acquired results；

4) coefficient of variation CV≤10% of repeatability is detected；

5) sample operating time be less than 2 minutes, 1h can survey 50-90 samples.

Certain the utility model can also detect the content of iodine in other samples in addition to the iodine in can detecting urine Or any material that can be analyzed by colorimetric determination.

Embodiment of the present utility model is the foregoing is only, the scope of the claims of the present utility model is not thereby limited, it is every The equivalent structure or equivalent flow conversion made using the utility model specification and accompanying drawing content, or be directly or indirectly used in Other related technical fields, are similarly included in scope of patent protection of the present utility model.

Claims (10)

1. a kind of quantitative analysis instrument, including housing, it is characterised in that circuit control system, colorimetric pool, optics are provided with housing and are passed Induction device, mini-printer；

Circuit control system include control module be connected with control module data acquisition module, Switching Power Supply, display device, RS-232 communication modules, data acquisition module is connected including light source launch driving circuit with light source launch driving circuit output end Light source radiating circuit, the light source that is connected with light source receiving circuit output end of light source receiving circuit receive amplifying circuit, light source hair The output end that the input of transmit-receive radio road, light source receive amplifying circuit is connected with control module, mini-printer and control module It is connected；Optical sensing devices include being arranged on light source radiating circuit plate, the light source circuit board for receiving of colorimetric pool side；

Colorimetric pool is cuboid solid construction, and top is provided with colorimetric pool lid, and middle part is provided with three equidistant cuvette grooves, positioned at test tube The corresponding two sides of trench bottom have three apertures.

2. quantitative analysis instrument according to claim 1, it is characterised in that control module includes MCU.

3. quantitative analysis instrument according to claim 2, it is characterised in that MCU uses STM32F103VBT6 single-chip microcomputers, its Inside includes AD conversion module.

4. quantitative analysis instrument according to claim 1, it is characterised in that display device includes being arranged on housing upper surface LCDs, 4 × 4 matrix keyboards.

5. quantitative analysis instrument according to claim 1, it is characterised in that light source radiating circuit includes that being located at light source launches electricity Three LEDs -1, LED-2, LED-3 on the plate of road, light source receiving circuit include being located on light source circuit board for receiving Three silicon photocell T1-T3.

6. quantitative analysis instrument according to claim 1, it is characterised in that light source launch driving circuit include triode Q2, Q3, Q5, resistance R42-R44, potentiometer R26-R28, resistance R42-base stages of the R44 respectively with triode Q2, Q3, Q5 are connected, Potentiometer R26-colelctor electrodes of the R28 respectively with triode Q2, Q3, Q5 is connected, and the emitter stage of triode Q2, Q3, Q5 is respectively with three Individual LED -1, LED-2, LED-3 are connected.

7. quantitative analysis instrument according to claim 1, it is characterised in that light source receives amplifying circuit and put including three computings Big device CA3140 and peripheral circuit, input is pin OPTI_IN_0, OPTI_IN_1, OPTI_IN_2, with light source receiving circuit It is connected, output end is connected to control module.

8. quantitative analysis instrument according to claim 1, it is characterised in that the bottom of colorimetric pool lid is provided with sealing test tube mouthful Waist type groove.

9. the quantitative analysis instrument according to claim 1 or 8, it is characterised in that the material of colorimetric pool is the impermeable finish of black Material.

10. quantitative analysis instrument according to claim 1, it is characterised in that shell back face-plate is provided with and Switching Power Supply phase Switch key, power interface, fuse, RS-232 serial ports even, the side of housing is provided with ventilating opening.