CN205917280U - Foldable soft membrane bioreactor and support frame thereof - Google Patents
Foldable soft membrane bioreactor and support frame thereof Download PDFInfo
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- CN205917280U CN205917280U CN201620635505.XU CN201620635505U CN205917280U CN 205917280 U CN205917280 U CN 205917280U CN 201620635505 U CN201620635505 U CN 201620635505U CN 205917280 U CN205917280 U CN 205917280U
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Abstract
The utility model relates to a biological fermentation cell culture field especially relates to a foldable soft membrane bioreactor and support frame thereof. Foldable soft membrane bioreactor has the mantle wall that comprises the plastics mantle, be equipped with on the mantle wall and mould the transversal ripple struction of personally submitting corrugated form that the shaping formed by mantle wall menstruation heat, elasticity was returned and is reduced after the ripple struction was expanded by the culture solution action of gravity, the easy three -dimensional inner chamber that forms and keep foldable soft membrane bioreactor, compared with the prior art, can realize like stereoplasm reaction vessel, do not need the air -blowing can carry out biological fermentation and cell culture, the operation is thus simple, high durability and convenient use, and can save dear air -blowing equipment, the equipment and use cost is greatly reduced. In addition, can be orderly fold condition under the state of non - use, save space to save transportation, germicidal treatment and storage cost.
Description
Technical field
This utility model is related to biofermentation field of cell culture, has especially related to a kind of collapsible soft membrane bioreaction
Answer device and its bracing frame.
Background technology
The Tissue Culture Flask of the cell culture container of hard material, such as static gas wave refrigerator, the taper of suspension culture is shaken
Bottle, cone bottom shaking flask, roller bottle and small-sized agitator tank etc., are now widely used biological cell culture instruments, and these cells are trained
Foster container is generally made up of glass or rigid plastics, the training that structural features are just provided with being provided from so ventilating and liquid material conveys
Foster vessel port and the three-dimensional endoluminal accommodating gas and liquid, have simple to operate, advantage easy to use.But hard material
Cell culture container have the shortcomings that it is difficult to overcome: i.e. glass container is reused not only needs the cleaning and sterilizing wasted time and energy
Preparation, but also the risk of potential cross-contamination；Although rigid plastics cell culture container can single use, due to
Its shape is fixing and volume is larger, and not only production cost is high, and waste generation is many, and in sterilizing, transport and storage and rubbish
The links such as process all lead to greatly expense to increase because it accommodates the space shared by three-dimensional endoluminal of gas.
Produce disposable folding mantle bioreactor or static gas wave refrigerator bag using plastic foil and carry out biofermentation and thin
Born of the same parents' culture is the major progress of biological technical field in recent years, and not only eliminate that glass drying oven use repeatly wastes time and energy is clear
Wash disinfection works, it is to avoid the risk of cross-contamination, and can overcome traditional hard plastics cell culture container volume
Greatly, production, sterilizing and cost of transportation height and waste produce many shortcomings.However, existing collapsible mantle bioreactor
The three-dimensional inner chamber accommodating gas and liquid in bag all can not be kept with the cell culture bags of static gas wave refrigerator under the conditions of natural ventilation,
For example, the wave cell culture for suspension culture of U.S. ge company utility model shake bag must be by continuous malleation air-blowing
Culture bag just can be made to expand and form the bag content gas inner chamber of supplied gas exchange, this continuous aerating apparatus are not only expensive,
And complex operation, it is especially unsuitable for the small-scale cell culture of laboratory；And the cell differentiation being used for static gas wave refrigerator breeds bag,
Although gas exchange and static gas wave refrigerator can be realized using the characteristic of its membrane material permeable watertight, three-dimensional in bag appearance can not be formed
Gas inner chamber thus efficient suspension culture can not be carried out.Because if arranging in existing cell culture bags as grit cell culture
Container equally supplies natural ventilation and the open container mouth of liquid material conveying, and two-layer mantle is in itself and culture fluid gravity sag and absorption
The air between two-layer mantle will be extruded, mantle tends to being attached in the presence of external pressure in the presence of power and pull strength
Together, thus losing gas exchange and inner space necessary to culture fluid mixing, and then lead to cultivate liquid from culture bag mouth
Overflow.Therefore, existing mantle culture bag or collapsible mantle bioreactor all can not be formed under natural ventilation state gas-
The three-dimensional endoluminal that liquid exchanges, being lost hard culture vessel while the shortcoming overcoming hard culture vessel to take up room makes
Use convenient advantage.In order to overcome existing cell culture bags/above-mentioned shortcoming of collapsible mantle bioreactor and realize as hard
The same simple to operate and easy to use of matter culture vessel, needs to research and develop and new can keep accommodating gas and liquid without air-blowing
The collapsible mantle bioreactor of inner chamber.
Utility model content
The purpose of this utility model is to provide one kind as hard culture vessel, simple to operate, easy to use, is not required to
Air-blowing just can keep its three-dimensional to hold the collapsible mantle bioreactor of gas inner chamber, and meanwhile, this utility model additionally provides one kind
For collapsible mantle bioreactor bracing frame matching used with above-mentioned collapsible mantle bioreactor.
For achieving the above object, this utility model employs the following technical solutions: collapsible mantle bioreactor, described folding
Stacked mantle bioreactor has the mantle wall being made up of plastic soft membrane, and described mantle wall is provided with and is become through thermoplastic by mantle wall
The cross section of type is in the ripple struction of bellows-shaped.
Further:
Described ripple struction is integrally rounded, oval, semicircle, the polygon of half elliptic, u shape or camber line interior angle.
Described ripple struction is provided with multi-turn, each circle ripple struction parallel nested setting successively.
Described collapsible mantle bioreactor includes primary diaphragm and the secondary diaphragm being stacked, primary diaphragm and
Two diaphragms have cavity portion and the mutual fusion around cavity portion setting being separated from each other when using and forming reaction chamber
Association part.
Described primary diaphragm is stiff sheet, and secondary diaphragm has described mantle wall, and the mantle wall of described secondary diaphragm is provided with
Described ripple struction, described primary diaphragm is provided with the stiff sheet ripple struction matching with the ripple struction on secondary diaphragm.
Described primary diaphragm and secondary diaphragm are respectively provided with described mantle wall, and secondary diaphragm is provided with described ripple struction, the
One diaphragm is provided with the tractive structure as outside tractive handgrip.
Described tractive structure is at least one of following three kinds of forms: form one, by mantle wall through thermoplastic shaping locally
Outwards swollen convex mantle steeps or the limit diaphragm through the heat seal of embedding folder by described mantle bubble；Form two, sticks to collapsible mantle
The external application diaphragm of bioreactor mantle wall outer surface, described external application diaphragm has and is pasted onto collapsible mantle bioreactor
The paste section of the outer surface of mantle wall and the pulling portion as tractive handgrip；Form three, insertion mantle wall simultaneously merges in mantle wall
On communicating pipe, the end face positioned at mantle pars intramuralis of communicating pipe is provided with the fusion piece blending with mantle wall, communicating pipe
Base portion outside positioned at mantle wall is provided with the draw-in groove that the locating fork for respective support frame snaps in.
Collapsible mantle bioreactor bracing frame, described collapsible mantle bioreactor bracing frame includes support body, frame
Body is provided with the supporting construction for supporting collapsible mantle bioreactor, is additionally provided with as collapsible mantle bioreactor
Ripple struction on mantle wall concedes the avoiding structure of expansive space.
Further:
Described supporting construction is formed by the primary diaphragm and secondary diaphragm for clamping collapsible mantle bioreactor
Association part folder frame.
Support body is provided with for the tractive structure on tractive collapsible mantle bioreactor so that collapsible mantle is biological
The corresponding mantle wall of reactor keeps setting the tractive location structure of shape.
Beneficial effect: the collapsible mantle bioreactor of this utility model three-dimensional endoluminal has to be become through thermoplastic by mantle wall
The cross section of type is in the ripple struction of bellows-shaped, by the ripple struction through thermoplastic shaping for the mantle wall, bullet after expansion
Property retraction little, easily form and keep the three-dimensional endoluminal of collapsible mantle bioreactor, compared with prior art, be capable of picture
Hard reaction container is the same, is not required to air-blowing and can carry out biofermentation and cell culture, simple to operate, easy to use, and can
To save the aerating apparatus of costliness, substantially reduce equipment cost and use cost.In addition, ripple struction is in the state of non-usage
Can be in orderly folded state, save space, thus saving transport, sterilization treatment and preserving cost.
Further, described primary diaphragm and secondary diaphragm are respectively provided with described mantle wall, and secondary diaphragm is provided with described ripple
Stricture of vagina structure, primary diaphragm is provided with the tractive structure as outside tractive handgrip, during use, is positioned by the tractive that outside is arranged
Structure carries out tractive to the volume tractive structure on mantle wall, you can so that the mantle wall of primary diaphragm is deformed, and is formed and sets shape
The three-dimensional endoluminal of shape.
Further, described tractive structure is insertion mantle wall and merges the communicating pipe on mantle wall, the position of communicating pipe
End face in mantle pars intramuralis is provided with the fusion piece blending with mantle wall, and the base portion outside positioned at mantle wall of communicating pipe sets
There is the draw-in groove that the prong for respective support frame snaps in, so, remove communicating pipe and there is gas inside and outside collapsible mantle bioreactor
Exchange and cultivate outside liquid material conveying function, be also used as tractive structure, merging piece when using as tractive structure can be to one-tenth
The mantle wall of piece carries out tractive, can reduce traction point position, reduces operation, simultaneously it can be avoided that gauffer in mantle wall.
Brief description
Fig. 1 is the folded state generalized section of this utility model embodiment 1；
Fig. 2 is the use state generalized section of this utility model embodiment 1；
Fig. 3 is the ripple struction overview of this utility model embodiment 1；
Fig. 4 is the use state overview of this utility model embodiment 1；
Fig. 5 is the structural representation of the primary diaphragm of this utility model embodiment 2；
Fig. 6 is the structural representation of the secondary diaphragm of this utility model embodiment 2；
Fig. 7 is the generalized section of this utility model embodiment 2；
Fig. 8 is the bracing frame of this utility model embodiment 2 and collapsible mantle bioreactor overview；
Fig. 9 is the horizontal Status view of the collapsible mantle bioreactor of this utility model embodiment 2；
Figure 10 is the horizontal use state schematic diagram of this utility model embodiment 2；
Figure 11 is the view being vertically arranged use state of this utility model embodiment 2；
Figure 12 is the side schematic view that this utility model embodiment 2 is vertically arranged use state；
Figure 13 is the structural representation of the top diaphragm of this utility model embodiment 3；
Figure 14 is the structural representation of the bracing frame of this utility model embodiment 3；
Figure 15 is the structural representation of the top diaphragm of this utility model embodiment 4；
Figure 16 is the structural representation of the top diaphragm of this utility model embodiment 5.
The each reference of in figure is corresponding entitled: 1- primary diaphragm, 2- secondary diaphragm, 3- stiff sheet ripple struction, and 4- is soft
Film ripple struction, 5- communicating pipe, 6- lid, 7- joint side, 8- mantle steeps, 9- supporting cantilever, 10- culture fluid, and 11- merges piece,
12- draw-in groove, 13- external application diaphragm, 14- presss from both sides frame, 15- locating fork, 16- locating clip, 17- hinge, 18- buckle, 19- bracing frame, 20-
Paste section, 21- pulling portion, 22- prong.
Specific embodiment
Embodiment 1:
As Figure 1-Figure 4, collapsible mantle bioreactor, including primary diaphragm 1 and second for the structure of this embodiment
Diaphragm 2, wherein primary diaphragm 1 are made using plastic hard plate and are carried stiff sheet ripple struction 3 thereon.In this utility model
" ripple struction " refers to the structure that cross section is bellows-shaped, and in the present embodiment, the ripple struction on primary diaphragm 1 is closure
Ripple coil structures, stiff sheet ripple struction 3 is overall to be rectangle, and is set to arc at its corner, that is, be in " rectangle of camber line interior angle ".
Middle part on primary diaphragm 1 is provided with communicating pipe 5, and communicating pipe 5 is to connect collapsible mantle bioreactor
Inside and outside passage, the communicating pipe 5 of the present embodiment is to be formed by top stiff sheet integration thermoplastic shaping.It is configured with logical on communicating pipe 5
Cross the lid 6 of all gap ventilations, this lid 6 is buckle closure." lid ventilated by all gaps " referred to herein refers to the inwall in lid
Gap is reserved, this gap can be used as ventilative leading to inside and outside collapsible mantle bioreactor between the outside wall surface of face and communicating pipe 5
Road.Certainly, in other embodiments, on communicating pipe 5, the lid 6 of configuration can also be closure (fully sealing) or band bacteriological filtration
The ventilative filter membrane lid of film.
Secondary diaphragm 2 is made using plastic soft membrane, forms mantle wall, has soft through thermoplastic shaping by mantle thereon
The shape of the stiff sheet ripple struction 3 on film ripple struction 4, the shape of mantle ripple struction 4 on secondary diaphragm 2 and primary diaphragm 1
The mantle ripple struction 4 of secondary diaphragm 2, therefore, in non-working condition, can be folded (turnover) to by shape matches mutually completely
In stiff sheet ripple struction 3 on one diaphragm 1, thus the space of its occupancy can be reduced, for the link provides convenient such as transporting, sterilizing,
Reduces cost, and stiff sheet ripple struction 3 has protective effect to mantle ripple struction 4.On primary diaphragm 1 and secondary diaphragm 2
The cross section of ripple struction substantially only there is the sine wave of a crest, more smooth container can be formed after deployment
Wall, is conducive to biological culture.Fig. 1, Fig. 3 show that the primary diaphragm 1 of collapsible mantle bioreactor and secondary diaphragm 2 fold
Later state..Primary diaphragm 1 and secondary diaphragm 2 have the cavity portion being separated from each other and forming reaction chamber and around cavity
Part setting mutual fusion association part, association part for and constitute a joint side 7, joint side 7 can be used as whole
The support of collapsible mantle bioreactor, collapsible mantle bioreactor is fixed or frame is at the position setting.
Fig. 2 and Fig. 4 respectively show the use state of this biological collapsible mantle bioreactor, during use, can pass through
Communicating pipe 5 injects culture fluid 10 into collapsible mantle bioreactor, because secondary diaphragm 2 uses mantle wall, therefore
Originally the secondary diaphragm 2 folding with primary diaphragm 1 can sagging expansion automatically under the action of gravity of culture fluid 10, from
And make to be formed in collapsible mantle bioreactor and keep stable three-dimensional endoluminal.Certainly, when some are special, also may be used
To arrange collapsible mantle bioreactor support base accordingly below collapsible mantle bioreactor, as shown in figure 4,
The groove that shape after molding is launched with secondary diaphragm 2 on support base is coincide, setting and collapsible soft membrane bioreaction at notch
The joint side 7 answering device seals the sealing structure coordinating, and during use, makes to be formed negative pressure in the groove on support base by suction, by
This helps more quick, the smooth expansion of secondary diaphragm 2 of collapsible mantle bioreactor, and due to mantle ripple struction
After expanding than plane mantle air-blowing after 4 expansion, elastic recovery force is little, therefore, easily forms three-dimensional internal space.
All can use under the collapsible mantle bioreactor horizontal of the present embodiment and vertical state, use in horizontal state
When, primary diaphragm is the top of collapsible mantle bioreactor, and secondary diaphragm is the bottom of collapsible mantle bioreactor,
When vertical state uses, primary diaphragm is the front portion of collapsible mantle bioreactor, and secondary diaphragm is collapsible mantle life
The rear portion of thing reactor.
The direction that the stiff sheet ripple struction 3 of the present embodiment all takes communicating pipe consistent with mantle ripple struction 4 is folded up,
With connect the mouth of pipe in the same direction, the packaging of collapsible mantle bioreactor can be made simple, packaging volume and the minimizing that takes up room, if
The direction contrary with communicating pipe is taken to fold the height that then can increase collapsible mantle bioreactor and take more spaces.Firmly
Piece ripple struction 3 and mantle ripple struction 4 are fitted together to, and have the effect protecting mantle ripple struction during shipping storage.
In other embodiments, the quantity of ripple struction can also be set to more than parallel two circles being nested with, ripple as needed
If stricture of vagina structure is set to two or more forms being nested with that are parallel to each other, collapsible mantle bioreactor exhibition can be increased
Depth after opening.Additionally, the global shape of ripple struction also can rounded, oval, the shape of standard track and field runway, semicircle
Shape, half elliptic, u shape or other polygonal geometry of camber line interior angle etc., but preferably employ at crest and seamlessly transit
Structure, produces shearing force to reduce as far as possible to biological cell.When the global shape of ripple struction is semicircle, half elliptic or u
During shape, it is preferably applied to vertical use state, make the opening up of semicircle, half elliptic or u shape, and so that ripple struction is set
Have the gently smooth position transition with corresponding diaphragm in the short transverse of ripple struction of the end of opening to be connected, reducing or
Eliminate fold.
Embodiment 2:
As is shown in figures 5-12, the differing only in of the present embodiment and embodiment 1: the first of collapsible mantle bioreactor
Diaphragm 1 is constituted for plane mantle, and secondary diaphragm 2 is also mantle, the shape of mantle ripple struction 4 of thermoplastic shaping and enforcement thereon
The mantle ripple struction of example 1 is identical, but folding direction is contrary.On the mantle of primary diaphragm 1, insertion is merged and is had as collapsible soft
The communicating pipe 5 of membrane bioreactor internal and external channel, on communicating pipe 5, the lid of configuration is closure or the ventilative filter membrane with bacteriological filtration film
Lid 6.Be there is the fusion piece 11 being blended with primary diaphragm 1 mantle inner face, the base portion of the communicating pipe 5 outside mantle sets communicating pipe 5
It is equipped with for outside tractive and fixing draw-in groove 12 so that communicating pipe 5 constituting tractive structure.Above-mentioned " fusion piece " refer to for soft
Film heat seal stiff sheet together, is equivalent to and defines part skeleton on the basis of mantle, can bear certain power and not send out
Raw moderate finite deformation, this means is prior art, is specifically no longer discussed in detail.
As shown in Fig. 8 Fig. 9 and Figure 10, the collapsible mantle bioreactor configurations of the present embodiment have and its shape size phase
The bracing frame 19 of adaptation, bracing frame 19 is provided with the folder frame 14 on the joint side 7 for fixed fold formula mantle bioreactor, folder
Frame 14 constitutes the supporting construction for supporting collapsible mantle bioreactor.Folder frame 14 includes upper strata folder frame and lower floor's folder frame,
The side that upper and lower layer presss from both sides frame forms rotating shaft by hinge 17, hinge 17 contrary opposite side is being provided with buckle 18, is pressing from both sides frame
It is provided with supporting cantilever 9, the projecting end of supporting cantilever 9 is provided with the communicating pipe for snapping in collapsible mantle bioreactor on 14
With tractive and the locating fork 15 positioning communicating pipe, the prong 22 of locating fork 15 and the draw-in groove 12 of communicating pipe 5 in the draw-in groove 12 of base portion
It is adapted；On folder frame 14, the frame plane that pivot center is formed with folder frame 14 hangs down the fixing end rolling assembling of supporting cantilever 9
Directly, consequently facilitating locating fork 15 snaps in draw-in groove 12 and screws out in draw-in groove 12.In order to mantle wall is formed with effective positioning,
Support cantilever 9 is elastic wall.Above-mentioned locating fork 15 formed for the tractive structure on tractive collapsible mantle bioreactor so that
The mantle wall of collapsible mantle bioreactor keeps setting the tractive location structure of shape, the space in the middle of the framework of folder frame 14
The ripple struction being configured on the mantle wall of collapsible mantle bioreactor concedes the avoiding structure of expansive space
During use, the collapsible mantle bioreactor of the present embodiment is placed between the two-layer folder frame 14 of bracing frame 19 simultaneously
By buckle 18, the collapsible mantle bioreactor of the present embodiment is fixedly clamped, presses down on and rotational positioning fork 15, make
Its prong 22 snaps among the draw-in groove 12 of communicating pipe 5, adds culture liquid material 10, according to different occupation modes, when horizontal uses,
As shown in Figure 10, the primary diaphragm 1 of collapsible mantle bioreactor pulls up under the elastic reaction of locating fork 15, folds
Mantle ripple struction 4 on formula mantle bioreactor secondary diaphragm 2 drops down under the action of gravity of culture liquid material 10, folding
Stacked mantle bioreactor forms the three-dimensional internal space of mixing and gas exchange for liquid；When vertically using, such as Figure 11,12
Shown, the primary diaphragm 1 of collapsible mantle bioreactor tractive forward under the elastic reaction of locating fork 15, collapsible mantle
Mantle ripple struction 4 on bioreactor secondary diaphragm 2 launches under the action of gravity of culture liquid material 10 backward, collapsible soft
Membrane bioreactor forms the three-dimensional internal space of mixing and gas exchange for liquid.In some cases, also can coordinate as real
Apply the method described in example 1, collapsible mantle is made by the vacuum suction effect of collapsible mantle bioreactor supported underneath seat
More quick, the smooth expansion of the secondary diaphragm 2 of bioreactor.
The present embodiment arranges a communicating pipe 5, in order to increase gas exchange efficiency and tractive convenience, may also set up 2
Above communicating pipe 5.
In the present embodiment, folder frame 14 forms the support body of collapsible mantle bioreactor bracing frame, in other embodiments,
Support body can also be other forms, such as frame form, and frame can also be passed through in the joint side 7 of collapsible mantle bioreactor
The clamp structure that is correspondingly arranged on frame is realized gripping, for top diaphragm be stiff sheet structure it is also possible to not to joint side 7
It is fixed, directly rely on the tractive structure on the diaphragm of top entirely collapsible mantle bioreactor to be carried out hang fixation.
Embodiment 3:
As shown in Figure 13-Figure 14, the present embodiment is with the difference of embodiment 2, and the tractive structure on primary diaphragm is served as reasons
The mantle bubble 8 for outside tractive of mantle thermoplastic shaping, in the collapsible mantle biological respinse supporting fixing the present embodiment
The locating clip 16 of tractive fixing mantle bubble 8 is additionally provided with the folder frame 14 of the bracing frame 19 of device.Above-mentioned locating clip 16 forms and is used for
Tractive structure on tractive collapsible mantle bioreactor is so that the mantle wall of collapsible mantle bioreactor keeps setting
The tractive location structure of shape.In the present embodiment, mantle bubble 8 is strip, and " mantle bubble " herein refers to be become through thermoplastic by mantle
Type and the mantle outwards heaved of local is swollen convex, mantle bubble 8 is deflated through clamping tractive when using, and forms the soft of double-deck mantle gauffer
Diaphragm, in other embodiments, the mantle bubble 8 of collapsible mantle bioreactor also can form mantle through the embedding folder of heat seal in advance
Piece, also can form two dropper hat shape mantle bubbles by thermoplastic shaping, form two mutually isolated traction points, according to 2 points of being aligneds
Reason, the effect of dropper hat shape mantle bubble 1 strip mantle bubble of equivalent tractive tractive of two points of tractive.
Embodiment 4:
As shown in figure 15, the differing only in of the present embodiment and embodiment 3: the tractive structure on primary diaphragm is external pasting film
Piece 13.External application diaphragm 13 is overall elongated, and section is t-shaped, and external application diaphragm 13 includes being pasted onto collapsible mantle biological respinse
The paste section 20 of device mantle outer surface and the pulling portion 21 as clamping or hook handgrip, the end of pulling portion 21 is pasted for both sides
The turning point in portion 20, can retain the annular ring of its hair fastener spline structure, and the prong for locating fork carries out hook.T shape external application diaphragm
Can be made by tack adhesive pad pasting, also can be made by electrostatic pad pasting, the worry of electrostatic pad pasting no colloid pollution.By quiet
During electric pad pasting absorption, paste section 20 width is more than the width of pulling portion 21, makes pulling portion 21 be in the centre position of paste section 20,
Survivable suction function makes absorption bigger, and the edge of tractive paste section 20 is easily destroyed negative pressure and makes paste section 20 from collapsible
Mantle bioreactor mantle is opened.
Embodiment 5:
As shown in figure 16, the present embodiment and the tractive bubble 8 differing only on primary diaphragm 1 of embodiment 3 are two, two
Individual tractive bubble is strip, and is mutually juxtaposed setting, and during use, the tractive folder on corresponding bracing frame is also two, leads
The mantle drawing rear secondary diaphragm 2 assumes 5 faces, and remaining is same as Example 3.
In other embodiments, the tractive structure on mantle wall can also be communicating pipe, mantle bubble, limit diaphragm and external pasting film
Other combining forms of piece, such as be respectively provided with communicating pipe as tractive structure, for another example same on primary diaphragm and secondary diaphragm
Arrange at least two of communicating pipe, mantle bubble, limit diaphragm and external application diaphragm on diaphragm simultaneously.
In this utility model, the embodiment of collapsible mantle bioreactor bracing frame is used in the various embodiments described above
Bracing frame, here is omitted for concrete structure.
Claims (10)
1. collapsible mantle bioreactor is it is characterised in that described collapsible mantle bioreactor has by plastic soft membrane
The mantle wall constituting, described mantle wall is provided with the ripple knot that the cross section through thermoplastic shaping by mantle wall is in bellows-shaped
Structure.
2. collapsible mantle bioreactor according to claim 1 is it is characterised in that described ripple struction is in integrally circle
Shape, ellipse, semicircle, the polygon of half elliptic, u shape or camber line interior angle.
3. collapsible mantle bioreactor according to claim 1 and 2 is it is characterised in that described ripple struction is provided with
Multi-turn, each circle ripple struction parallel nested setting successively.
4. collapsible mantle bioreactor according to claim 1 and 2 is it is characterised in that described collapsible mantle is given birth to
Thing reactor includes the primary diaphragm being stacked and secondary diaphragm, and primary diaphragm and secondary diaphragm have and mutually divide when using
From and formed reaction chamber cavity portion and around cavity portion setting mutual fusion association part.
5. collapsible mantle bioreactor according to claim 4 it is characterised in that described primary diaphragm be stiff sheet,
Secondary diaphragm has described mantle wall, and the mantle wall of described secondary diaphragm is provided with described ripple struction, on described primary diaphragm
It is provided with the stiff sheet ripple struction matching with the ripple struction on secondary diaphragm.
6. collapsible mantle bioreactor according to claim 4 is it is characterised in that described primary diaphragm and the second film
Piece is respectively provided with described mantle wall, and secondary diaphragm is provided with described ripple struction, and primary diaphragm is provided with as outside tractive handgrip
Tractive structure.
7. collapsible mantle bioreactor according to claim 6 is it is characterised in that described tractive structure is following three
At least one of kind of form: form one, by mantle wall through thermoplastic shaping local outwards swollen convex mantle bubble or by described mantle
The limit diaphragm through the heat seal of embedding folder for the bubble；Form two, sticks to the external application of collapsible mantle bioreactor mantle wall outer surface
Diaphragm, described external application diaphragm has the paste section of the outer surface of mantle wall being pasted onto collapsible mantle bioreactor and conduct
The pulling portion of tractive handgrip；Form three, insertion mantle wall simultaneously merges the communicating pipe on mantle wall, communicating pipe positioned at mantle wall
Internal end face is provided with the fusion piece blending with mantle wall, and the base portion outside positioned at mantle wall of communicating pipe is provided with for corresponding
The draw-in groove that the locating fork of bracing frame snaps in.
8. it is used for supporting the collapsible mantle bioreactor of collapsible mantle bioreactor as claimed in claim 1 to support
It is characterised in that described collapsible mantle bioreactor bracing frame includes support body, support body is provided with collapsible for supporting frame
The supporting construction of mantle bioreactor, is additionally provided with and concedes for the ripple struction on the mantle wall of collapsible mantle bioreactor
The avoiding structure of expansive space.
9. collapsible mantle bioreactor bracing frame according to claim 8 is it is characterised in that described supporting construction is
The folder frame of the association part being formed for the primary diaphragm and secondary diaphragm that clamp collapsible mantle bioreactor.
10. collapsible mantle bioreactor bracing frame according to claim 8 is it is characterised in that support body is provided with use
Tractive structure on tractive collapsible mantle bioreactor is so that the corresponding mantle wall of collapsible mantle bioreactor is protected
Hold the tractive location structure setting shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620635505.XU CN205917280U (en) | 2016-06-24 | 2016-06-24 | Foldable soft membrane bioreactor and support frame thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620635505.XU CN205917280U (en) | 2016-06-24 | 2016-06-24 | Foldable soft membrane bioreactor and support frame thereof |
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| Publication Number | Publication Date |
|---|---|
| CN205917280U true CN205917280U (en) | 2017-02-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201620635505.XU Expired - Fee Related CN205917280U (en) | 2016-06-24 | 2016-06-24 | Foldable soft membrane bioreactor and support frame thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112867783A (en) * | 2018-10-20 | 2021-05-28 | 东洋制罐集团控股株式会社 | Sphere culture member, culture container, method for processing perforated member, and washing container |
-
2016
- 2016-06-24 CN CN201620635505.XU patent/CN205917280U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112867783A (en) * | 2018-10-20 | 2021-05-28 | 东洋制罐集团控股株式会社 | Sphere culture member, culture container, method for processing perforated member, and washing container |
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