CN205849883U - A kind of hollow fiber film type blood cardioplegia device for casting - Google Patents
A kind of hollow fiber film type blood cardioplegia device for casting Download PDFInfo
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- CN205849883U CN205849883U CN201620554691.4U CN201620554691U CN205849883U CN 205849883 U CN205849883 U CN 205849883U CN 201620554691 U CN201620554691 U CN 201620554691U CN 205849883 U CN205849883 U CN 205849883U
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Abstract
A kind of hollow fiber film type blood cardioplegia device for casting, belongs to technical field of medical instruments.Upper cover is stuck in the top of shell, and in the base, inner core is placed in shell the lower end card of shell, and the inner chamber after upper cover is connected with inner core is blood storage groove, and there is second row pore on the top of upper cover, is above stamped outlet and blood inlet；First row pore is arranged at the top of shell；Blood outlet is arranged at the bottom of shell；Blood outlet connects temperature-measuring port, and base has water inlet；Hollow fiber membrane bundle is placed between shell and inner core；Base side wall is provided with water inlet, and upper cover sidewall is provided with outlet；On be covered with the blood inlet communicated with blood storage groove, outer casing underpart is provided with blood outlet.This utility model has automatic lifting temperature function, both can guarantee that the alternating temperature effect having excellence, and had had preferable protected effect, beneficially the carrying out of post-operative to blood, and beneficially patient's post-operative recovery, simultaneously simple in construction, cheap, can be accepted extensively by market.
Description
Technical field
This utility model relates to a kind of hollow fiber film type blood cardioplegia device for casting, belongs to medical device technology neck
Territory.
Background technology
The early 21st century, along with the raising of living standards of the people, unscientific diet and living habit so that cardiovascular disease
Sick sickness rate drastically raises, and the health of serious threat people, cardiovascular disease has become as the No.1 of urban and rural residents of China and kills
Hands.Extracorporeal circulation cardiovascular surgical procedure, as a kind of new technique, is one of the most effective treatment means.
When operation on heart, cardiac arrest, by extracorporeal circulation apparatus by defeated for the blood rich in oxygen through peroxo
Send health back to, to keep the oxygen supply demand of whole body.In the process, the blood supply to heart itself has 2 functions: ensure
The oxygen of cardiac muscle supplies；By cardioplegic solution input cardiac muscle, it is ensured that heart keeps stoping jumping state at intra-operative.The temperature of cardiac muscle is direct
Affecting the oxygen consumption of cardiac muscle, temperature is the highest, and oxygen consumption is the biggest, so should be maintained at 4-10 degree at operation process Myocardial.
Before operation terminates, the temperature of heart is returned to normal body temperature 37 degree.
Present continuous form outer circulation blood temperature varying device mainly has two classes:
1, current domestic manufacturer is to be lengthened by hemorrhage pipeline, puts into the effect reaching to change blood temperature in frozen water or warm water, this
The method of kind is cheap, but alternating temperature weak effect, little to myocardial preservation, postoperative cardiac rebeating difficulty, it is unfavorable for patient's post-operative recovery,
Seriously can cause death；Add working time and the workload of perfusionist simultaneously.
2, the extracorporeally circulating blood changing device of existing market upper inlet, does not adjusts by adding frozen water or warm water in use
The method of joint blood temperature, has automatic lifting temperature device, alternating temperature excellent effect, has preferable protected effect to blood, but price is high
High, it is only suitable for only a few crowd, extensive patients cannot accept.
Although the blood cardioplegia device for casting of more external company research and development can accomplish good thermoregulation effect and to blood
Liquid has preferable protected effect, but its price is high, is only applicable to only a few crowd, and extensive patients cannot accept.
It is by being lengthened by hemorrhage pipeline that the blood of more domestic manufacturer production stops jumping device, puts in frozen water or warm water and reaches
To the effect of change blood temperature, although this kind of method is cheap, but alternating temperature weak effect, little to myocardial preservation, postoperative cardiac rebeating
Difficulty, is unfavorable for patient's post-operative recovery, can cause death time serious；When adding workload and the work of perfusionist simultaneously
Between.
Summary of the invention
In order to overcome the deficiencies in the prior art, this utility model provides a kind of hollow fiber film type blood cardioplegia perfusion dress
Put.
A kind of hollow fiber film type blood cardioplegia device for casting, upper cover is stuck in the top of shell, and the lower end of shell is stuck in
In base, inner core is placed in shell, and the inner chamber after upper cover is connected with inner core is blood storage groove, and there is second exhaust on the top of upper cover
Hole, is above stamped outlet and blood inlet；First row pore is arranged at the top of shell；Blood outlet is arranged at the bottom of shell；Blood outlet connects
Temperature-measuring port, base has water inlet；Hollow fiber membrane bundle is placed between shell and inner core；Base side wall is provided with water inlet, upper cover
Sidewall is provided with outlet；On be covered with the blood inlet communicated with blood storage groove, outer casing underpart is provided with blood outlet.
Upper cover, shell, inner core, base and temperature-measuring port are connected by draw-in groove respectively.
Blood storage groove is connected with blood.
Hollow fiber membrane bundle is assembled between shell and inner core by binding agent.
Upper cover height 27～45mm.Substructure height 12～30mm.Outer cover height 60～150mm；Housing diameter 40～
100mm；Inner core diameter 20～50mm.Blood outlet distance substructure height 5～25mm.Enter blood mouth distance blood outlet height be 65～
95mm.Second exhaust pitch-row separates out blood open height 82～112mm.
A kind of hollow fiber film type blood cardioplegia method for filling, containing following steps；
By leaking water in hollow fiber membrane bundle, external blood circulation carries out heat exchange, and carries out temperature control；
Hollow-fibre membrane is utilized to have good blood blending, do not destroy for blood, each in the blood that adequately protects
Plant composition；
It is respectively provided with steam vent at upper cover and shell upper, fully gets rid of the bubble in blood, prevent from producing in operation
Raw bubble enters in human vas, prevents owing to operation occurs the possibility of aeroembolism；
Blood flows from top to bottom, and temperature control water flows from bottom to top so that blood leaves extracorporeally circulating blood changing device
Time, the temperature of blood is consistent with temperature control coolant-temperature gage；
Blood outlet arranges temperature-measuring port, installs temperature probe, observes the change of temperature in time, it is achieved temperature automatically controlled function,
Decrease the workload of doctor, for doctor in operation process time-consuming；
Alternating temperature water is directly entered in Fiber tube type alternating temperature film by water inlet, discharges from outlet after taking away heat；Upper cover sets
Having the blood inlet communicated with blood storage groove, shell upper is provided with steam vent, and outer casing underpart is provided with blood outlet, blood and stop jumping liquid and pass through
Blood inlet initially enters blood storage groove, then flows between shell and inner core, is flowed from top to bottom by the gap of fiber pipe interfascicular,
Carry out heat exchange with the alternating temperature water in pipe, got rid of by blood outlet after alternating temperature；
Blood enters blood mouth at upper cover and flows into, and is from top to bottom flowed by doughnut intermembrane space, finally minimum at shell
End flows out；Alternating temperature water flows into from base, by flowing from bottom to top inside hollow-fibre membrane, is finally flowed out by upper cover；Enter blood mouth
Maximum with the difference in height of blood outlet, it is the longest that blood contacts distance with hollow-fibre membrane, and blood and hollow-fibre membrane contact area are
Greatly, homoiothermic is rapid, carries out temperature control；
Two steam vents have removal of bubbles ability；Blood outlet is arranged on the least significant end of shell, and steam vent a is arranged on
Lid top, gets rid of the bubble in blood when having just enter into；Steam vent b is arranged on the top of shell, gets rid of blood in alternating temperature mistake
Issuable gas in journey；
Blood heat is observed in time, to realize automatic lifting temperature function by temperature probe.
Being connected by draw-in groove between this utility model assembly, the processing for each parts is convenient, and cost is lower；Blood
From top to bottom flowing in doughnut intermembrane space, carry out heat exchange with alternating temperature water from bottom to top in pipe, heat exchange area is big,
Homoiothermic is rapid, and temperature control is effective；Blood outlet is connected with temperature-measuring port, can observe blood heat in time；Priming volume is little；Collection storage blood,
Relent thermometric in one, simplify apparatus structure.
This utility model carries out alternating temperature by hollow-fibre membrane, the good biocompatibility of material, has automatic lifting Wen Gong
Can, both can guarantee that the alternating temperature effect having excellence, and blood had been had preferable protected effect, beneficially the carrying out of post-operative, has
It is beneficial to patient's post-operative recovery, simultaneously simple in construction, cheap, can be accepted extensively by market.
This utility model has the advantage that
1, the good biocompatibility of material.
2, alternating temperature excellent effect.The changing device of annular carries out alternating temperature by hollow-fibre membrane, enters blood mouth high with blood outlet
Degree difference maximum, blood is maximum with hollow-fibre membrane contact area, and homoiothermic is rapid, temperature control excellent effect.
3, excellent gas elimination ability.It is provided with two steam vents, first row pore and second row pore respectively with hemorrhage
Difference in height between Kou maximizes, and fully eliminates the gas in blood.
4, it is provided with temperature measuring equipment in blood outlet position, the temperature of blood outlet blood can be observed the moment, in order to realize certainly
Dynamic heating and cooling function.
5, product priming volume is little.
6, integrate storage blood, relent thermometric, simplifies apparatus structure.
7, cheap, can be accepted extensively by market.
8, the inlet outlet pressure differential of blood is little, improves the security performance of product.
Accompanying drawing explanation
When considered in conjunction with the accompanying drawings, by referring to detailed description below, it is possible to be more completely more fully understood that this practicality is new
Type and easily learn the advantage that many of which is adjoint, but accompanying drawing described herein be used for providing to of the present utility model enter one
Step understands, constituting a part of the present utility model, schematic description and description of the present utility model is used for explaining this practicality
Novel, it is not intended that improper restriction of the present utility model, such as figure wherein:
Fig. 1 is structural representation of the present utility model.
Fig. 2 is cross section structure schematic diagram of the present utility model.
With embodiment, this utility model is further illustrated below in conjunction with the accompanying drawings.
Detailed description of the invention
Obviously, the many modifications and variations that those skilled in the art are done based on objective of the present utility model belong to this practicality
Novel protection domain.
Those skilled in the art of the present technique are appreciated that unless expressly stated, singulative used herein " ", "
Individual ", " described " and " being somebody's turn to do " may also comprise plural form.It is to be further understood that description of the present utility model uses
Wording " include " referring to there is described feature, integer, step, operation, element and/or assembly, but it is not excluded that existence or
Add other features one or more, integer, step, operation, element, assembly and/or their group.It should be understood that when us
Claiming element to be " connected " or during " coupled " to another element, it can be directly connected or coupled to other elements, or can also
There is intermediary element.Additionally, " connection " used herein or " coupling " can include wireless connections or couple.Used herein arrange
Diction "and/or" includes one or more any cell listing item being associated and all combinations.
Those skilled in the art of the present technique are appreciated that unless otherwise defined, and all terms used herein (include technology art
Language and scientific terminology) have with the those of ordinary skill in this utility model art be commonly understood by identical meaning.Also
It should be understood that those terms defined in such as general dictionary should be understood that have with in the context of prior art
The consistent meaning of meaning, and unless defined as here, will not explain by idealization or the most formal implication.
For ease of the understanding to this utility model embodiment, below in conjunction with accompanying drawing do as a example by several specific embodiments into
The explanation of one step, and each embodiment is not intended that the restriction to this utility model embodiment.
Embodiment 1: as shown in Figure 1 and Figure 2, a kind of hollow fiber film type blood cardioplegia device for casting, upper cover 13, shell
8, inner core 10, base 9 and temperature-measuring port 6 five part are connected by draw-in groove respectively, and upper cover 13 is stuck in the top of shell 8, shell 8
Lower end is stuck in base 9, and inner core 10 is placed in shell 8, and the inner chamber after upper cover 13 is connected with inner core 10 is blood storage groove 12, upper cover
The top of 13 has second row pore 7, upper cover 13 to have outlet 2 and blood inlet 1；First row pore 3 is arranged at the top of shell 8；Shell 8
Bottom have blood outlet 5；Blood outlet 5 connects temperature-measuring port 6, and base 9 has water inlet 4；Hollow fiber membrane bundle 11 be placed on shell 8 with
Between inner core 10.
Blood is connected with blood storage groove 12, and the upper cover 13 being positioned at top is connected with shell 8 by draw-in groove, shell 8, inner core 10
Being connected with base 9 with upper cover 13 by draw-in groove, hollow fiber membrane bundle 11 is assembled between shell 8 and inner core 10 by binding agent.
Base 9 sidewall is provided with water inlet 4, and upper cover 13 sidewall is provided with outlet 2, and alternating temperature water is directly entered fibre by water inlet 4
In dimension tubular type alternating temperature film, discharge from outlet 2 after taking away heat.
Upper cover 13 is provided with the blood inlet 1 communicated with blood storage groove, and shell 8 top is provided with first row pore 3, and shell 8 bottom sets
Having blood outlet 5, blood initially enters blood storage groove with stoping jumping liquid by blood inlet 1, then flows between shell 8 and inner core 10, logical
Flowing from top to bottom in the gap crossed between hollow fiber membrane bundle 11, carries out heat exchange with the alternating temperature water in pipe, by hemorrhage after alternating temperature
Mouth 5 is got rid of.
Embodiment 2: as shown in Figure 1 and Figure 2, a kind of hollow fiber film type blood cardioplegia device for casting is divided into 5 parts,
Upper cover 13, shell 8, inner core 10, base 9 and temperature-measuring port 6 five part are connected by draw-in groove,
By leaking water in hollow fiber membrane bundle 11, external blood circulation carries out heat exchange, and contact area is big, and temperature control effect has in time
Effect；
Hollow fiber membrane bundle 11 uses polymer inlet material to make, and has good blood blending, does not has for blood
There is destruction, various compositions in the blood that adequately protected；
Second row pore 7 is set at upper cover 13, gets rid of the bubble in blood, prevent the bubble produced in operation from entering people
Body Ink vessel transfusing, prevents owing to operation occurs the possibility of aeroembolism；Blood flows from top to bottom, and temperature control water flows from bottom to top so that
When blood leaves extracorporeally circulating blood changing device, the temperature of blood is consistent with temperature control coolant-temperature gage；
Blood outlet 5 arranges temperature-measuring port 6 so that doctor, when operation, is regulated with temperature control by the flow velocity of regulation temperature control water
Blood heat, simple to operation, for doctor in operation process time-consuming；
Blood is connected with blood storage groove 12, eliminates storage blood bag device, simplifies device similar in market, reduce
Product cost, reduces priming volume.
The upper cover 13 being positioned at top is connected with shell 8 by draw-in groove, and shell 8, inner core 10 are by draw-in groove and upper cover 13 and the end
Seat 9 connects, and hollow fiber membrane bundle 11 is assembled between shell 8 and inner core 10 by binding agent.
Base 9 sidewall is provided with water inlet 4, and upper cover 13 sidewall is provided with outlet 2, and alternating temperature water is directly entered fibre by water inlet 4
In dimension tubular type alternating temperature film, discharge from outlet 2 after taking away heat.
Upper cover 13 is provided with the blood inlet 1 communicated with blood storage groove, and shell 8 top is provided with first row pore 3, and shell 8 bottom sets
Having blood outlet 5, blood initially enters blood storage groove with stoping jumping liquid by blood inlet 1, then flows between shell 8 and inner core 10, logical
Flowing from top to bottom in the gap crossed between hollow fiber membrane bundle 11, carries out heat exchange with the alternating temperature water in pipe, by hemorrhage after alternating temperature
Mouth 5 is got rid of.
Embodiment 2: as shown in Figure 1 and Figure 2, the hollow fiber film type extracorporeally circulating blood changing device of a kind of annular, it is divided into
5 parts, upper cover, shell, inner core, base, temperature probe, five parts are connected by draw-in groove, and simple in construction is easy to assembly, valency
Lattice are cheap.
By leaking water in hollow fiber membrane bundle, external blood circulation carries out heat exchange, and contact area is big, and temperature control effect has in time
Effect；Hollow-fibre membrane uses polymer inlet material to make, and has good blood blending, does not destroy for blood, fill
Divide and protect various compositions in blood；It is respectively provided with steam vent at upper cover and shell upper, fully gets rid of the bubble in blood,
Prevent the bubble produced in operation from entering in human vas, prevent owing to operation occurs the possibility of aeroembolism；Blood is from top to bottom
Flowing, temperature control water flows from bottom to top so that when blood leaves extracorporeally circulating blood changing device, the temperature of blood and temperature control water
Temperature is consistent；Blood outlet arranges temperature-measuring port, installs temperature probe so that can observe the change of temperature in time, in order to realize
Temperature automatically controlled function, decreases the workload of doctor, for doctor in operation process time-consuming；Blood is connected with blood storage groove
Connect, eliminate storage blood bag device, simplify device similar in market, reduce product cost, reduce priming volume.
The upper cover being positioned at top is connected with shell by draw-in groove, and shell, inner core are connected with base with upper cover by draw-in groove, in
Hollow fiber film is assembled between shell and inner core by binding agent.Base side wall is provided with water inlet, and upper cover sidewall is provided with outlet,
Alternating temperature water is directly entered in Fiber tube type alternating temperature film by water inlet, discharges from outlet after taking away heat.On be covered with and store up blood
The blood inlet that groove communicates, shell upper is provided with steam vent, and outer casing underpart is provided with blood outlet, and blood passes through blood inlet head with stoping jumping liquid
It is introduced into blood storage groove, then flows between shell and inner core, flowed from top to bottom by the gap of fiber pipe interfascicular, and in pipe
Alternating temperature water carries out heat exchange, is got rid of by blood outlet after alternating temperature.
The processing of each parts of this utility model is convenient, simple in construction, and cost is lower；
This utility model alternating temperature excellent effect, the extracorporeally circulating blood changing device of annular is become by hollow-fibre membrane
Temperature, has the alternating temperature effect of excellence.Blood enters blood mouth at upper cover and flows into, and is from top to bottom flowed by doughnut intermembrane space,
Least significant end at shell flows out eventually；Alternating temperature water flows into from base, by flowing from bottom to top inside hollow-fibre membrane, finally by upper
Lid flows out.Entering blood mouth maximum with the difference in height of blood outlet, it is the longest that blood contacts distance with hollow-fibre membrane, blood and doughnut
Film contact area is maximum, and homoiothermic is rapid, temperature control excellent effect；
This utility model is provided with two steam vents, has the removal of bubbles ability of excellence.Blood outlet is arranged on shell
Least significant end, steam vent a is arranged on upper cover top so that the difference in height of the two maximizes, when fully eliminating has just enter in blood
Bubble；Steam vent b is arranged on the top of shell, and the difference in height between blood outlet maximizes, and eliminates blood further
Issuable gas during alternating temperature；
This utility model blood outlet is connected with temperature-measuring port, can observe blood heat in time by temperature probe, to realize
Automatic lifting temperature function；
This utility model priming volume is little, and priming volume is 20～55ml；
The inlet outlet pressure differential of this utility model blood is little, improves the security performance of product；
This utility model integrates storage blood, relent thermometric, simplifies apparatus structure；
The size of hollow fiber film type blood cardioplegia device for casting of this utility model annular: upper cover height 27～
45mm；Substructure height 12～30mm；Outer cover height 60～150mm；Housing diameter 40～100mm；Inner core diameter 20～50mm；Go out
Blood mouth distance substructure height 5～25mm；Entering blood mouth distance blood outlet height is 65～95mm；Second exhaust pitch-row is high from blood outlet
Degree 82～112mm.
As it has been described above, embodiment of the present utility model is explained, but as long as essentially without disengaging
Inventive point of the present utility model and effect can have a lot of deformation, and this is apparent to one skilled in the art
's.Therefore, within such variation is also integrally incorporated in protection domain of the present utility model.
Claims (9)
1. a hollow fiber film type blood cardioplegia device for casting, it is characterised in that upper cover is stuck in the top of shell, shell
In the base, inner core is placed in shell lower end card, and the inner chamber after upper cover is connected with inner core is blood storage groove, and the top of upper cover has
Two steam vents, are above stamped outlet and blood inlet；First row pore is arranged at the top of shell；Blood outlet is arranged at the bottom of shell；Hemorrhage
Mouth connects temperature-measuring port, and base has water inlet；Hollow fiber membrane bundle is placed between shell and inner core；Base side wall is provided with into water
Mouthful, upper cover sidewall is provided with outlet；On be covered with the blood inlet communicated with blood storage groove, outer casing underpart is provided with blood outlet.
A kind of hollow fiber film type blood cardioplegia device for casting the most according to claim 1, it is characterised in that upper cover, outer
Shell, inner core, base and temperature-measuring port are connected by draw-in groove respectively.
A kind of hollow fiber film type blood cardioplegia device for casting the most according to claim 1, it is characterised in that blood storage groove
It is connected with blood inlet.
A kind of hollow fiber film type blood cardioplegia device for casting the most according to claim 1, it is characterised in that hollow is fine
Dimension perineurium is assembled between shell and inner core by binding agent.
A kind of hollow fiber film type blood cardioplegia device for casting the most according to claim 1, it is characterised in that upper cover is high
Degree 27～45mm.
A kind of hollow fiber film type blood cardioplegia device for casting the most according to claim 1, it is characterised in that base is high
Degree 12～30mm.
A kind of hollow fiber film type blood cardioplegia device for casting the most according to claim 1, it is characterised in that shell is high
Degree 60～150mm；Housing diameter 40～100mm；Inner core diameter 20～50mm.
A kind of hollow fiber film type blood cardioplegia device for casting the most according to claim 1, it is characterised in that blood outlet
Distance substructure height 5～25mm.
A kind of hollow fiber film type blood cardioplegia device for casting the most according to claim 1, it is characterised in that enter blood mouth
Distance blood outlet height is 65～95mm；Second exhaust pitch-row separates out blood open height 82～112mm.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620554691.4U CN205849883U (en) | 2016-06-07 | 2016-06-07 | A kind of hollow fiber film type blood cardioplegia device for casting |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201620554691.4U CN205849883U (en) | 2016-06-07 | 2016-06-07 | A kind of hollow fiber film type blood cardioplegia device for casting |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107432960A (en) * | 2017-09-12 | 2017-12-05 | 东莞科威医疗器械有限公司 | A kind of double helix water conservancy diversion integrated form membrane oxygenator |
| CN110575578A (en) * | 2018-06-08 | 2019-12-17 | 东莞科威医疗器械有限公司 | Oxygenator with enhanced exhaust function |
| CN113499496A (en) * | 2021-07-14 | 2021-10-15 | 江苏赛腾医疗科技有限公司 | Membrane oxygenator with built-in filter |
| CN114739207A (en) * | 2022-03-09 | 2022-07-12 | 广州国家实验室 | Heat exchanger and oxygenator |
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2016
- 2016-06-07 CN CN201620554691.4U patent/CN205849883U/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107432960A (en) * | 2017-09-12 | 2017-12-05 | 东莞科威医疗器械有限公司 | A kind of double helix water conservancy diversion integrated form membrane oxygenator |
| CN107432960B (en) * | 2017-09-12 | 2024-01-09 | 东莞科威医疗器械有限公司 | Spiral diversion integrated film type oxygenator |
| CN110575578A (en) * | 2018-06-08 | 2019-12-17 | 东莞科威医疗器械有限公司 | Oxygenator with enhanced exhaust function |
| CN110575578B (en) * | 2018-06-08 | 2022-09-23 | 东莞科威医疗器械有限公司 | Oxygenator with enhanced exhaust function |
| CN113499496A (en) * | 2021-07-14 | 2021-10-15 | 江苏赛腾医疗科技有限公司 | Membrane oxygenator with built-in filter |
| CN113499496B (en) * | 2021-07-14 | 2022-03-25 | 江苏赛腾医疗科技有限公司 | Membrane oxygenator with built-in filter |
| US11724014B2 (en) | 2021-07-14 | 2023-08-15 | Jiangsu Stmed Technology Co., Ltd. | Membrane oxygenator with built-in filter |
| CN114739207A (en) * | 2022-03-09 | 2022-07-12 | 广州国家实验室 | Heat exchanger and oxygenator |
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Address after: Hexi Road Yanqi 101407 Beijing city Huairou District No. 9 Patentee after: Beijing meadows Medical Equipment Co., Ltd Address before: Hexi Road Yanqi 101407 Beijing city Huairou District No. 9 Patentee before: BEIJING MEDOS AT BIOTECHNOLOGY Co.,Ltd. |
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| CP01 | Change in the name or title of a patent holder |