CN109224163B - A kind of hollow fiber membrane oxygenator that heat exchange layers are external - Google Patents
A kind of hollow fiber membrane oxygenator that heat exchange layers are external Download PDFInfo
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- CN109224163B CN109224163B CN201811205286.1A CN201811205286A CN109224163B CN 109224163 B CN109224163 B CN 109224163B CN 201811205286 A CN201811205286 A CN 201811205286A CN 109224163 B CN109224163 B CN 109224163B
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- blood
- oxygen
- hot water
- oxygenator
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1621—Constructional aspects thereof
- A61M1/1623—Disposition or location of membranes relative to fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
- A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
- A61M1/1698—Blood oxygenators with or without heat-exchangers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3666—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
Abstract
The invention discloses a kind of hollow fiber membrane oxygenators that heat exchange layers are external.The oxygenator includes shell and the upper end cover and lower cover that are removably mounted on shell；The shell includes oxygenator shell, hot water unit inner casing, oxygen conjunction cell enclosure and core pipe from outside to inside；The oxygenator shell and hot water unit inner casing constitute the cavity of hot water unit, and the hot water unit inner casing and oxygen close cell enclosure and constitutes blood heat exchange chamber, and the oxygen closes cell enclosure and core pipe constitutes the cavity that oxygen closes unit；The blood heat exchange chamber closes unit with oxygen and is connected to by circumferential aperture.Hot water unit of the invention is arranged in oxygen and closes unit periphery, gas exchange efficiency not only can be improved, but also temperature loss can be made to reduce to minimum, to reach highest oxygenation efficiency.In addition, the oxygenator temperature gradient is minimum, thrombosed probability in blood can significantly reduce.Meanwhile the blood temperature after oxygen conjunction can bring preferably treatment experience close to inside of human body temperature.
Description
Technical field
The invention belongs to the field of medical instrument technology.More particularly, to a kind of hollow-fibre membrane that heat exchange layers are external
Formula oxygenator.
Background technique
During Cardio-pulmonary Operation clinical treatment, core component, that is, oxygenator of extracorporal circulatory system is always in occupation of important work
With.Membrane oxygenator, which is also known as " artificial lung ", completes blood of human body in vitro for the blood extracorporeal circulation of cardiac operation under direct vision
Oxygen and carbon dioxide exchange, i.e. " oxygen conjunction " function.Therefore, membrane oxygenator belongs to Biomedical engineering industry, is that life is supported
The core component of equipment extracorporeal membrane oxygenation system, belongs to strategic emerging industries major products.
Mainly there are two functions, i.e. heat exchange (hot water unit) and blood oxygenation for the oxygenator generally used currently on the market
(oxygen conjunction unit).Wherein, hot water unit mainly plays a part of to maintain blood temperature, there is hollow-fibre membrane hot water unit and metal material
The hot water unit of matter；Oxygen closes unit and mainly plays discharge blood carbon dioxide, increases the effect of oxygen, is commonly doughnut at present
Film oxygen closes unit.Hot water unit and oxygen close the usual arranged concentric of unit, including hot water unit, oxygen closes unit external, the two tree
Rouge encapsulating, fixation.The oxygenator that oxygen flow ability is good, heat exchanger effectiveness is high greatly facilitates effect to therapeutic process.
Existing oxygenator is commonly built in hot water unit on the market, oxygen closes unit external structure, and venous blood first passes through hot water
Unit, then flow into oxygen and close unitary gas exchange, it is converted into arterial blood outflow, blood is during the oxygenator oxygen of this structure closes
There are temperature to decline apparent problem, and excessive temperature gradient will affect the uniformity of blood flow and the exchange effect of gas
Rate results even in thrombosis, causes unnecessary pain and trouble to patient.
Summary of the invention
The technical problem to be solved by the present invention is to overcome above-mentioned the deficiencies in the prior art, and it is external to provide a kind of heat exchange layers
The uniformity of hollow fiber membrane oxygenator, the blood flow caused by improving because of excessive temperature gradient reduces and the friendship of gas
The deficiency for changing efficiency decline, reduces the probability of thrombosis.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of hollow fiber membrane oxygenator that heat exchange layers are external, including shell and is removably mounted on shell
Upper end cover 11 and lower cover 16；The shell include from outside to inside oxygenator shell 12, hot water unit inner casing 13, oxygen close unit outside
Shell 14 and core pipe 15；The oxygenator shell 12 constitutes the cavity of hot water unit 21, the hot water list with hot water unit inner casing 13
First inner casing 13 closes the composition blood heat exchange chamber of cell enclosure 14 with oxygen, and the oxygen closes cell enclosure 14 and core pipe 15 constitutes oxygen and closes list
The cavity of member 22；The blood heat exchange chamber closes unit 22 with oxygen and is connected to by circumferential aperture.
Oxygenator of the invention closes 22 periphery of unit, phase during blood oxygenation, since hot water unit 21 is arranged in oxygen
When being equipped with one layer " insulating layer " in closing the periphery of unit 22 in oxygen, gas exchange efficiency can be improved.It is hot in hot water unit 21 of the present invention
Water does not stop to circulate, and remains at " insulating layer " temperature closest in the range of inside of human body temperature, and then make whole
The temperature loss that a oxygen closes unit 22 reduces to minimum, so that blood be made to be in always during oxygen closes closest to inside of human body
In temperature environment, to reach highest oxygenation efficiency.Moreover, oxygenator uniformity of temperature profile of the invention, temperature gradient is minimum,
It can significantly reduce thrombosed probability in blood.Simultaneously as oxygen of the present invention close after blood temperature close to inside of human body temperature
Degree, for patient when receiving the blood without increasing blood temperature by loss body temperature, patient temperature fluctuation is small, can bring more
Good treatment experience.
Preferably, in the hot water unit 21 equipped with circulating type hot-water cavity 2 and positioned at 2 both ends of hot-water cavity into
Water pipe 19 and outlet pipe 1；Wherein, the water inlet pipe 19 is located on the lower cover 16, and the outlet pipe 1 is located at the upper end cover
On 11, to form water route.The hot-water cavity 2 is cylindric circulating type hot-water cavity, for providing constant heat for heat exchanging process
Measure source.Intracavitary to be full of hot water when normal use, heat, which is passed through, to be conducted with the heat exchange layers inner casing 13 that hot water directly contacts to temperature
In lower blood, capacity of heat transmission is stronger, and heat exchanger effectiveness is higher.
It is highly preferred that the outlet pipe 1, water inlet pipe 19 and 2 vertical connection of hot-water cavity.
Preferably, the end that the oxygen closes unit 22 is respectively equipped with upper gas chamber 7 and lower gas chamber 71；Upper gas
Chamber 7 is connected to the air inlet pipe 5 for being set to 11 middle part of upper end cover, and lower gas chamber 71 connects with the escape pipe 18 being set on lower cover 16
Logical, upper gas chamber 7 closes the hollow-fibre membrane in unit 22 by oxygen with lower gas chamber 71 and is connected to, to form gas circuit.Oxygen
Gas enters through air inlet pipe 5 and is full of upper gas chamber 7, then closes unit 22 via oxygen and flow downward to lower gas chamber 7, closes in oxygen
Convection current is formed with blood in unit 22 and carries out gas exchanges, finally flows out oxygenator, oxygen and blood pair via escape pipe 18
To flowing, gas exchange efficiency is high.
It is highly preferred that the upper gas chamber 7 is cylindrical；The lower gas chamber 71 is annular.
It is highly preferred that the 5 vertical connection upper gas chamber 7 of air inlet pipe, 18 vertical connection lower gas chamber 71 of escape pipe.
It is highly preferred that the lower gas chamber 71 is with hot-water cavity 2 around 16 central axis arranged concentric of lower cover.
Preferably, the oxygen closes 14 lower end of cell enclosure and is equipped at least one first circumferential aperture 20, in the core pipe 15
End is equipped at least one second circumferential aperture 23；Helical form blood flow passage is equipped in the blood heat exchange chamber；The blood stream
It is closed with the first circumferential aperture 20 of 14 lower end of cell enclosure from the hot water unit inner casing 13 and oxygen of threaded type blood channel in road
Composition；Blood enters oxygen by the first circumferential aperture 20 and closes unit 22, and it is circumferential to flow to second along hollow-fibre membrane pipe outer wall
Aperture 23 enters 15 inner cavity of core pipe from the second circumferential aperture 23, and flows out oxygenator by going out blood vessel 17, to form bloody path.
Helical metal blood flow passage is distributed in 13 inner surface of heat exchange layers inner casing, can dramatically increase blood and intermetallic heat exchange
Area, so that hot water and blood be made to carry out sufficient heat exchange.
Preferably, the outside of the air inlet pipe 5 has been arranged concentrically exhaust passage 6 and channel of blood flow around 11 central axis of upper end cover
4；4 upper end of channel of blood flow passes through blood chamber 3 and the helical form with being connected on upper end cover 11 into blood vessel 10, lower end is set to
Blood flow passage connection.
It is highly preferred that exhaust passage 6 is concentrically disposed in 5 periphery of air inlet pipe, channel of blood flow 4 is concentrically disposed in exhaust passage 6
Periphery.Exhaust passage 6, channel of blood flow 4, blood chamber 3 and air inlet pipe 5 around end cap central axis arranged concentric and are integrally formed.
It is further preferred that the exhaust passage 6 is in a ring；The channel of blood flow 4 is twist.
Preferably, the middle part of the lower cover 16 be equipped with taper blood collection chamber, and be horizontally installed on lower cover 16
Go out blood vessel 17 be connected；The blood vessel 17 out is arranged in the same direction with into blood vessel 10, to simplify piping connection.
Venous blood is reached after flowing through spiral shape channel of blood flow 4 by vortex flowing is tangentially flowed into and formed into blood vessel 10
Blood chamber 3；In blood chamber 3, blood is by (runner is by threaded in the conical surface inflow helical form blood flow passage with constant slope
The hot water unit inner casing 13 of type blood channel closes cell enclosure 14 with the oxygen of lower end aperture and matches to be formed)；Bubble in blood
Be discharged, then be collected into exhaust passage 6 via the conical surface with gradient by centrifugal force effect in vortex movement, finally via
Oxygenator is discharged in exhaust pipe 9.
When blood flows in helical form blood flow passage, hot friendship first is carried out via hot water unit inner casing 13 and hot water unit 21
Change, the blood after alternating temperature flows into oxygen via the first circumferential aperture 20 that oxygen closes 14 lower end of cell enclosure and closes unit 22, then by lower and
On pass through entire oxygen outside the hollow-fibre membrane that oxygen closes unit 22 and close unit, close the gas from top to bottom flowed in unit 22 with oxygen
After carrying out gas exchanges by the micropore on doughnut membranous wall, core pipe is flowed into via the second circumferential aperture 23 of 15 upper end of core pipe
15 inner cavities, and then oxygenator is flowed out by going out blood vessel 17.
Preferably, the bypass of blood vessel 17 out is provided with artery temperature tube 26 and radial arterial pressure tube 27, for measuring bleeding
The blood temperature and pressure of pipe 17；It is described to be equipped with vein temperature tube 24 and vein pressure-measuring pipe 25 into the bypass of blood vessel 10, for measuring
Into the blood temperature and pressure of blood vessel 10.
Preferably, the outer edge of the described first circumferential aperture 20 and the second circumferential aperture 23 is fillet.The fillet
Design can sufficiently mitigate when blood flows through duct and the shear action of bore edges, reduces blood damage degree.
Preferably, the inner cavity top of core pipe 15 is equipped with sealing element 8 with rounded corners.15 top blood of core pipe is circumferential via second
When aperture 23 flows into 15 inner cavity of core pipe, blood is flowed along the fillet curve of sealing element 8, is substantially prevented from the formation of flow dead zone.
Preferably, upper end cover 11, lower cover 16 and oxygenator shell 12, hot water unit inner casing 13, oxygen close cell enclosure 14
Connecting portion be equipped with pyramidal projections, to be positioned and be connect with oxygenator shell, and by tapered surface to coupling part
It is sealed, guarantees the airtightness of each chamber.
It is arranged it is highly preferred that lower cover 16 also closes the coupling part between cell enclosure 14 in hot water unit inner casing 13 and oxygen
There is the annular wall of sealing.The annular wall is located at hot water unit inner casing 13 and oxygen closes interlayer and the lower end of 14 lower end of cell enclosure
The joint of lid 16.
Preferably, the material of hot water unit inner casing 13 is metal material.Since the material of the hot water unit inner casing 13 is heat
The excellent metal of conductive performance, capacity of heat transmission is stronger, thus the heat exchange of higher efficiency can be carried out with blood.
Preferably, the upper end cover 11, lower cover 16 are combined closely with oxygenator shell 12 by buckle structure 28.
Preferably, in oxygenator shell of the present invention, oxygenator shell 12, hot water unit 21, hot water unit inner casing 13, oxygen are closed
Cell enclosure 14 and oxygen close unit 22 and surround 15 arranged concentric of core pipe.After oxygen conjunction 22 both ends of unit are sealed with resin
Glue is cut, fixed hollow fiber conduit simultaneously keeps both ends unobstructed.
Compared with prior art, the invention has the following beneficial effects:
(1) structure of the invention is ingenious in design, reasonable and compact, and during blood oxygenation, hot water unit is arranged in oxygen conjunction
Unit periphery, the temperature loss that can not only make entire oxygen close unit reduces to minimum, but also gas exchange efficiency can be improved, with
Reach highest oxygenation efficiency.In addition, oxygenator uniformity of temperature profile of the invention, temperature gradient is minimum, can significantly reduce blood
Thrombosed probability in liquid.Simultaneously as the blood temperature after oxygen conjunction of the present invention is close to inside of human body temperature, patient is receiving
Body temperature fluctuation is small when the blood, can bring preferably treatment experience.
(2) oxygenator of the invention is in heat exchanging process, heat exchange of the heat through being in direct contact with it of hot water unit
Layer inner casing is conducted into the lower blood of temperature, which is distributed with helical metal blood flow passage, energy
Blood and intermetallic heat exchange area are dramatically increased, simultaneously because the inner casing material is the excellent metal of heat-conductive characteristic,
Capacity of heat transmission is stronger, therefore carries out the more efficient of heat exchange with blood.
(3) present invention closes the circumferential aperture outer edge in cell enclosure and core pipe to oxygen and has carried out fillet processing, can subtract
When light blood flows through duct and the shear action of bore edges, blood damage degree is reduced.
(4) after blood of the present invention uniformly flows into oxygen conjunction unit and carries out gas exchanges, then via the second week of core pipe upper end
To aperture even into core pipe inner cavity, it is equipped with cylinder seal with rounded corners in core pipe inner cavity, so that blood is along sealing element
Fillet curve flowing, is substantially prevented from the formation of flow dead zone.
Detailed description of the invention
Fig. 1 is the entirety sectional view of oxygenator of the present invention.
Fig. 2 is the structural schematic diagram of upper end cover of the present invention.
Fig. 3 is the structural schematic diagram of lower cover of the present invention.
Fig. 4 is the structural schematic diagram of hot water unit inner casing of the present invention.
Fig. 5 is the structural schematic diagram that oxygen of the present invention closes cell enclosure.
Fig. 6 is the structural schematic diagram of core pipe of the present invention.
Fig. 7 is the structural schematic diagram of oxygenator of the present invention.
Wherein, 1- outlet pipe, 2- column annular hot-water cavity, 3- blood chamber, 4- channel of blood flow, 5- air inlet pipe, 6- exhaust are logical
Road, 7- upper gas chamber, 8- sealing element, 9- exhaust pipe, 10- is into blood vessel, 11- upper end cover, 12- oxygenator shell, 13- hot water list
First inner casing, 14- oxygen close cell enclosure, 15- core pipe, 16- lower cover, and 17- goes out blood vessel, 18- escape pipe, 19- water inlet pipe, 20- the
One circumferential aperture, 21- hot water unit, 22- oxygen close unit, and the circumferential aperture of 23- second, 24- vein temperature tube, 25- vein, which is surveyed, presses
Pipe, 26- artery temperature tube, 27- radial arterial pressure tube, 28- buckle structure, 71- lower gas chamber.
Specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment, attached drawing only for illustration, should not be understood as
Limitation to this patent；In order to better illustrate this embodiment, the certain components of attached drawing have omission, zoom in or out, and do not represent
The size of actual product；To those skilled in the art, in attached drawing certain known features and its explanation may omit be can
With understanding.Positional relationship is described in attached drawing only for illustration, should not be understood as the limitation to this patent.
A kind of external hollow fiber membrane oxygenator of the heat exchange layers of embodiment 1
A kind of hollow fiber membrane oxygenator that heat exchange layers are external, as shown in Figure 1, whole cylindrical；The oxygenator
Including shell and the upper end cover being removably mounted on shell 11 and lower cover 16；Shell includes oxygenator shell from outside to inside
12, hot water unit inner casing 13, oxygen close cell enclosure 14 and core pipe 15；Oxygenator shell 12 and hot water unit inner casing 13 constitute hot water
The cavity of unit 21, hot water unit inner casing 13 and oxygen close cell enclosure 14 and constitute blood heat exchange chamber, oxygen close cell enclosure 14 with
Core pipe 15 constitute oxygen close unit 22(, that is, oxygen flow hollow-fibre membrane) cavity.
As shown in Fig. 2, being respectively equipped with outlet pipe 1, air inlet pipe 5, exhaust pipe 9 and into blood vessel 10 on upper end cover 11.Into blood
The bypass of pipe 10 is equipped with vein temperature tube 24 and vein pressure-measuring pipe 25.Vein temperature tube 24, vein pressure-measuring pipe 25 are respectively used in real time
Oxygenator is measured and monitored into the temperature of blood, pressure in blood vessel 10.
Upper end cover 11 is connect with the top that oxygenator shell 12, hot water unit inner casing 13 and oxygen close cell enclosure 14, point
For 7 three layers of columnar circulating type hot-water cavity 2, blood chamber 3 and cylindrical upper gas chamber.Exhaust passage 6, channel of blood flow 4, blood
Chamber 3 around end cap central axis arranged concentric and is integrally formed with air inlet pipe 5.Exhaust passage 6 is concentrically disposed in 5 periphery of air inlet pipe, blood
Circulation road 4 is concentrically disposed in 6 periphery of exhaust passage.
As shown in figure 3, being respectively equipped with out blood vessel 17, escape pipe 18 and water inlet pipe 19 on lower cover 16.In blood vessel 17 out
Bypass is provided with artery temperature tube 26 and radial arterial pressure tube 27；Artery temperature tube 26, radial arterial pressure tube 27 are respectively used to survey in real time
Amount and monitoring oxygenator go out the temperature of blood, pressure in blood vessel 17.
Lower cover 16 is connect with the lower part that oxygenator shell 12, hot water unit inner casing 13 and oxygen close cell enclosure 14, point
For column annular hot-water cavity 2, three layers of the lower gas chamber 71 and taper blood collection chamber of annular.Taper blood collection chamber is set to down
The middle part of end cap 16, and be connected with the blood vessel 17 that goes out being horizontally installed on lower cover 16.Lower gas chamber 71 and hot-water cavity 2 are under
16 central axis arranged concentric of end cap.
Blood vessel 17 is arranged in the same direction with into blood vessel 10 out, to simplify piping connection.
2 both ends of hot-water cavity are equipped with water inlet pipe 19 and outlet pipe 1；Outlet pipe 1, water inlet pipe 19 and 2 vertical connection of hot-water cavity,
To form water route.Hot-water cavity 2 is used to provide Constant Heat source for heat exchanging process.It is intracavitary to be full of hot water when normal use,
Heat, which is passed through, to be conducted with the heat exchange layers inner casing 13 that hot water directly contacts into the lower blood of temperature, and capacity of heat transmission is stronger,
Heat exchanger effectiveness is higher.
The end that the oxygen closes unit 22 is respectively equipped with the lower gas chamber 71 of cylindrical upper gas chamber 7 and annular；Top
Air chamber 71 and 5 vertical connection of air inlet pipe for being set to 11 middle part of upper end cover, lower gas chamber 71 and going out on lower cover 16
18 vertical connection of tracheae, upper gas chamber 7 close the hollow-fibre membrane in unit 22 by oxygen with lower gas chamber 71 and are connected to, thus
Form gas circuit.Oxygen enters through air inlet pipe 5 and is full of upper gas chamber 7, then closes unit 22 via oxygen and flow downward to lower part gas
Body cavity 7 forms convection current with blood in oxygen conjunction unit 22 and carries out gas exchanges, finally flows out oxygenator via escape pipe 18,
Oxygen and the flowing of blood opposite direction, gas exchange efficiency are high.
As shown in figure 4, helical metal blood flow passage is distributed in 13 inner surface of heat exchange layers inner casing, blood can be dramatically increased
Liquid and intermetallic heat exchange area, so that hot water and blood be made to carry out sufficient heat exchange.
As shown in figure 5, oxygen, which closes 14 lower end of cell enclosure, is equipped with 4 first circumferential apertures 20.
As shown in fig. 6,15 upper end of core pipe is equipped with 4 second circumferential apertures 23.
Helical form blood flow passage is equipped in blood heat exchange chamber；Blood flow passage by threaded type blood channel hot water unit
The first circumferential aperture 20 that inner casing 13 closes 14 lower end of cell enclosure with oxygen, which is matched, to be combined into；Blood enters by the first circumferential aperture 20
Oxygen closes unit 22, flow to the second circumferential aperture 23 along hollow-fibre membrane pipe outer wall, enters core pipe from the second circumferential aperture 23
15 inner cavities, and oxygenator is flowed out by going out blood vessel 17, to form bloody path.
The outside of air inlet pipe 5 is arranged concentrically the exhaust passage 6 and spiral blood flow of annular around 11 central axis of upper end cover
Channel 4；4 upper end of channel of blood flow passes through blood chamber 3 and helical form blood with being connected on upper end cover 11 into blood vessel 10, lower end is set to
Runner connection.
The material of the hot water unit inner casing 13 is metal material.Since the material of the hot water unit inner casing 13 is heat conductivity
The excellent metal of energy, capacity of heat transmission is stronger, thus the heat exchange of higher efficiency can be carried out with blood.
Venous blood is reached after flowing through spiral shape channel of blood flow 4 by vortex flowing is tangentially flowed into and formed into blood vessel 10
Blood chamber 3；In blood chamber 3, blood is by (runner is by threaded in the conical surface inflow helical form blood flow passage with constant slope
The hot water unit inner casing 13 of type blood channel closes cell enclosure 14 with oxygen and matches to be formed)；Bubble in blood is moved in vortex
In be discharged by centrifugal force effect, then be collected into exhaust passage 6 via the conical surface with gradient, finally via 9 row of exhaust pipe
Oxygenator out.
When blood flows in helical form blood flow passage, hot friendship first is carried out via hot water unit inner casing 13 and hot water unit 21
Change, the blood after alternating temperature flows into oxygen via the first circumferential aperture 20 that oxygen closes 14 lower end of cell enclosure and closes unit 22, then by lower and
On pass through entire oxygen outside the hollow-fibre membrane that oxygen closes unit 22 and close unit, close the gas from top to bottom flowed in unit 22 with oxygen
After carrying out gas exchanges by the micropore on fiber membranous wall, flowed into core pipe 15 via the second circumferential aperture 23 of 15 upper end of core pipe
Chamber, and then oxygenator is flowed out by going out blood vessel 17.
The oxygenator of the present embodiment closes 22 periphery of unit during blood oxygenation, since hot water unit 21 is arranged in oxygen,
It is equivalent to and closes 22 periphery of unit equipped with one layer " insulating layer " in oxygen, gas exchange efficiency can be improved.In hot water unit 21 of the present invention
Hot water does not stop to circulate, and remains at " insulating layer " temperature closest in the range of inside of human body temperature, and then make
The temperature loss that entire oxygen closes unit 22 reduces to minimum, so that blood be made to be in always during oxygen closes closest to inside of human body
Temperature environment in, to reach highest oxygenation efficiency.Moreover, oxygenator uniformity of temperature profile of the invention, temperature gradient pole
It is small, it can significantly reduce thrombosed probability in blood.Simultaneously as oxygen of the present invention close after blood temperature close to inside of human body
Temperature, for patient when receiving the blood without increasing blood temperature by loss body temperature, patient temperature fluctuation is small, can bring
Preferably treatment experience.
A kind of external hollow fiber membrane oxygenator of the heat exchange layers of embodiment 2
In order to further increase the synthesis using effect of oxygenator, the external hollow-fibre membrane of the heat exchange layers of the present embodiment
Formula oxygenator on the basis of embodiment 1, has carried out following improvement:
As shown in Fig. 1, Fig. 5 and Fig. 6, in the external hollow fiber membrane oxygenator of the present embodiment heat exchange layers, oxygen is closed
The outer edge of 4 first of 14 lower end of cell enclosure circumferential apertures 20 and 4 second circumferential apertures 23 of 15 upper end of core pipe is
Fillet.The fillet design can sufficiently mitigate when blood flows through duct and the shear action of bore edges, reduces blood damage degree.
Sealing element 8 with rounded corners is equipped on the inner cavity top of core pipe 15.15 top blood of core pipe flows into core via the second circumferential aperture 23
When 15 inner cavity of pipe, blood is flowed along the fillet curve of sealing element 8, is substantially prevented from the formation of flow dead zone.Upper end cover 11, lower cover
16 with oxygenator shell 12, hot water unit inner casing 13, oxygen close cell enclosure 14 connecting portions be equipped with pyramidal projections, to oxygen
Clutch shell is positioned and is connected, and is sealed by tapered surface to coupling part, guarantees the airtightness of each chamber.Separately
Outside, lower cover 16 also closes the annular that the coupling part between cell enclosure 14 is provided with sealing in hot water unit inner casing 13 and oxygen
Wall.The annular wall is located at hot water unit inner casing 13 and oxygen closes the interlayer of 14 lower end of cell enclosure and the joint of lower cover 16.
First core pipe 15 is sealed with the cylinder seal 8 that fillet is handled.Oxygen is closed with disposable integrated filling process again single
First 22(, that is, oxygen flow hollow-fibre membrane) it closes cell enclosure 14 with core pipe 15, oxygen and is combined, it is closed with this and unit is closed by core pipe 15 and oxygen
Shell 14 forms oxygenation chamber.Finally oxygenator shell 12, hot water unit inner casing 13, oxygen are closed with disposable integrated glue envelope technique
Cell enclosure 14 and upper end cover 11, lower cover 16 combine, so as to form hot-water cavity and screw thread shape heat exchange chamber.Outside heat exchange layers
The nesting type structure for being placed on oxygen conjunction layer connect with upper and lower end caps and seals the gas circuit to form fully separating formula, bloody path, water route, structure
It is compact, priming volume is small.
As shown in fig. 7, the upper end cover 11, lower cover 16 are combined closely with oxygenator shell 12 by buckle structure 28,
It is easy to disassemble while guaranteeing leakproofness.
In the present embodiment oxygenator shell, oxygenator shell 12, hot water unit 21, hot water unit inner casing 13, oxygen close unit
Shell 14 and oxygen close unit 22 and surround 15 arranged concentric of core pipe.Oxygen closes after 22 both ends of unit are sealed with resin and cuts glue, Gu
Determine hollow fiber conduit and keeps both ends unobstructed.
Oxygen flow hollow-fibre membrane is made using the excellent novel high polymer material PMP of blood compatibility in the present embodiment；Using
The hot water unit inner casing 13 of threaded type blood channel is made in the stainless steel metal material of blood compatibility and excellent heat transfer properties；
21 jacket-type of hot water unit is arranged in oxygen and closes unit outer layer, so that oxygenator internal temperature gradient is uniform, blood temperature is steadily protected
It holds in body temperature level, thermal loss is small；Oxygenator integrally uses nesting type structure to arrange, compact-sized, and priming volume is small；Interface position
Set science；Using the safe and reliable fast connection interface of standard；Blood reaches blood chamber 3 tangentially into helical form channel of blood flow 4,
The centrifugalization in vortex flowing of bubble in blood is discharged, and is collected into exhaust passage 6 via the conical surface with gradient,
Oxygenator is discharged via exhaust pipe 9 again, bubble removing ability is good；The screw-type blood channel of metal quality directly and contacting blood,
Flow path is long, and alternating temperature area is big, and alternating temperature is high-efficient；Blood from top to bottom flows through screw thread shape heat exchange chamber, then from bottom to top leads to
Peroxide closes unit, sufficiently closes unit with oxygen and contacts, and oxygen conjunction area is big, and flow path is long, and it is good that oxygen closes effect；Uniform body temperature oxygen closes
Environment, blood oxygen in uniform body temperature environment close, and oxygenation efficiency is high；Blood is flowed out from core pipe 15, along the sealing element 8 of fillet processing
Flowing is flowed without dead zone, more evenly.
The oxygen closes the bilayer oxygen flow doughnut made of the excellent novel high polymer material PMP of blood compatibility of unit 22
Film roll system is sealed using the disposable integrated glue of import glue, between the fiber crossovers arrangement in each layer of hollow-fibre membrane
There are angles, so that overcoming effect of boundary layer during blood flow, improve oxygenation efficiency.
Claims (9)
1. a kind of hollow fiber membrane oxygenator that heat exchange layers are external, which is characterized in that including shell and detachable installation
Upper end cover (11) and lower cover (16) on shell；The shell includes oxygenator shell (12), hot water unit from outside to inside
Inner casing (13), oxygen close cell enclosure (14) and core pipe (15)；The oxygenator shell (12) and hot water unit inner casing (13) are constituted
The cavity of hot water unit (21), the hot water unit inner casing (13) and oxygen close cell enclosure (14) and constitute blood heat exchange chamber, institute
It states oxygen and closes the cavity that cell enclosure (14) and core pipe (15) constitute oxygen conjunction unit (22)；The blood heat exchange chamber and oxygen close unit
(22) pass through circumferential aperture connection；The oxygen closes cell enclosure (14) lower end and is equipped at least one first circumferential aperture (20), institute
Core pipe (15) upper end is stated equipped at least one the second circumferential aperture (23)；Helical form blood stream is equipped in the blood heat exchange chamber
Road；The blood flow passage closes the of cell enclosure (14) lower end by the hot water unit inner casing (13) and oxygen of threaded type blood channel
One circumferential aperture (20), which is matched, to be combined into；Blood enters oxygen by the first circumferential aperture (20) and closes unit (22), along doughnut
Membrane tube outer wall flow to the second circumferential aperture (23), enters core pipe (15) inner cavity from the second circumferential aperture (23), and pass through bleeding
It manages (17) and flows out oxygenator, to form bloody path.
2. hollow fiber membrane oxygenator according to claim 1, which is characterized in that be equipped in the hot water unit (21)
Circulating type hot-water cavity (2) and the water inlet pipe (19) and outlet pipe (1) for being located at the hot-water cavity (2) both ends；Wherein, it is described into
Water pipe (19) is located on the lower cover (16), and the outlet pipe (1) is located on the upper end cover (11), to form water route.
3. hollow fiber membrane oxygenator according to claim 1, which is characterized in that the oxygen closes the end of unit (22)
It is respectively equipped with upper gas chamber (7) and lower gas chamber (71)；Upper gas chamber (7) and the air inlet being set in the middle part of upper end cover (11)
(5) connection is managed, lower gas chamber (71) is connected to the escape pipe (18) being set on lower cover (16), and upper gas chamber (7) is under
Portion's air chamber (71) is closed the hollow-fibre membrane in unit (22) by oxygen and is connected to, to form gas circuit.
4. hollow fiber membrane oxygenator according to claim 3, which is characterized in that the outside of the air inlet pipe (5) around
Upper end cover (11) central axis has been arranged concentrically exhaust passage (6) and channel of blood flow (4)；Channel of blood flow (4) upper end be set to
Being connected on upper end cover (11) into blood vessel (10), lower end is connected to by blood chamber (3) with spiral helicine blood flow passage.
5. hollow fiber membrane oxygenator according to claim 4, which is characterized in that set in the middle part of the lower cover (16)
There is taper blood collection chamber, and is connected with go out blood vessel (17) being horizontally installed on lower cover (16)；It is described go out blood vessel (17) with
It is arranged in the same direction into blood vessel (10).
6. hollow fiber membrane oxygenator according to claim 5, which is characterized in that blood vessel (17) the out bypass setting
There are artery temperature tube (26) and radial arterial pressure tube (27)；It is described to be equipped with vein temperature tube (24) and vein survey into blood vessel (10) bypass
Pressure pipe (25).
7. hollow fiber membrane oxygenator according to claim 1, which is characterized in that the first circumferential aperture (20) and
The outer edge of described second circumferential aperture (23) is fillet.
8. any hollow fiber membrane oxygenator according to claim 1~7, which is characterized in that the inner cavity of core pipe (15)
Top is equipped with sealing element with rounded corners (8)；Upper end cover (11), lower cover (16) and oxygenator shell (12), hot water unit inner casing
(13), the connecting portion that oxygen closes cell enclosure (14) is equipped with pyramidal projections.
9. according to any hollow fiber membrane oxygenator of claim 8, which is characterized in that hot water unit inner casing (13)
Material is metal material.
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| CN201811205286.1A CN109224163B (en) | 2018-10-16 | 2018-10-16 | A kind of hollow fiber membrane oxygenator that heat exchange layers are external |
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| CN201811205286.1A CN109224163B (en) | 2018-10-16 | 2018-10-16 | A kind of hollow fiber membrane oxygenator that heat exchange layers are external |
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| CN109224163B true CN109224163B (en) | 2019-06-21 |
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Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN217391279U (en) * | 2019-09-06 | 2022-09-09 | 西安西京医疗用品有限公司 | Membrane oxygenator |
| CN113509605B (en) * | 2021-07-14 | 2022-09-20 | 江苏赛腾医疗科技有限公司 | Membrane oxygenator |
| CN113499496B (en) * | 2021-07-14 | 2022-03-25 | 江苏赛腾医疗科技有限公司 | Membrane oxygenator with built-in filter |
| CN113398354B9 (en) | 2021-07-14 | 2022-05-03 | 江苏赛腾医疗科技有限公司 | Integrated membrane oxygenator |
| CN113350596A (en) * | 2021-07-19 | 2021-09-07 | 北京航空航天大学 | Oxygenator and extracorporeal membrane lung oxygenation device |
| CN113413504B (en) * | 2021-07-30 | 2023-03-14 | 北京清瀚医疗科技有限公司 | Multi-chamber oxygenator with liquid separation drainage structure |
| CN114642780B (en) * | 2022-02-16 | 2022-10-14 | 山东威高新生医疗器械有限公司 | Integrated membrane oxygenator |
| CN115041353B (en) * | 2022-05-31 | 2023-03-14 | 广州国家实验室 | Oxygenating membrane wire sleeve, oxygenator, glue filling method and glue filling device |
| CN115920161A (en) * | 2022-07-13 | 2023-04-07 | 苏州心擎医疗技术有限公司 | Oxygenator |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5120501A (en) * | 1988-10-20 | 1992-06-09 | Baxter International Inc. | Integrated membrane blood oxygenator/heat exchanger |
| US5217689A (en) * | 1989-10-26 | 1993-06-08 | Baxter International Inc. | Blood oxygenation system |
| IT1255820B (en) * | 1992-08-10 | 1995-11-16 | Nicola Ghelli | HEAT EXCHANGER IN EXTRACORPOREAL BLOOD CIRCUIT |
| JP4366268B2 (en) * | 2004-07-23 | 2009-11-18 | テルモ株式会社 | Artificial lung |
| JP5913345B2 (en) * | 2010-11-15 | 2016-04-27 | ソリン・グループ・イタリア・ソシエタ・ア・レスポンサビリタ・リミタータ | Blood processing unit for circumferential blood flow |
| US10188780B2 (en) * | 2013-12-23 | 2019-01-29 | University Of Maryland, Baltimore | Blood oxygenator |
| CN204364532U (en) * | 2014-12-13 | 2015-06-03 | 西安西京医疗用品有限公司 | A kind of membrane oxygenator |
| CN105833373A (en) * | 2016-06-13 | 2016-08-10 | 北京米道斯医疗器械有限公司 | Hollow fiber membrane oxygenator and method |
| CN107485744B (en) * | 2017-09-12 | 2019-08-30 | 东莞科威医疗器械有限公司 | A kind of membrane oxygenator |
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