CN107485744B - A kind of membrane oxygenator - Google Patents
A kind of membrane oxygenator Download PDFInfo
- Publication number
- CN107485744B CN107485744B CN201710817386.9A CN201710817386A CN107485744B CN 107485744 B CN107485744 B CN 107485744B CN 201710817386 A CN201710817386 A CN 201710817386A CN 107485744 B CN107485744 B CN 107485744B
- Authority
- CN
- China
- Prior art keywords
- partition
- oxygen
- blood
- ring
- water conservancy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000012528 membrane Substances 0.000 title claims abstract description 77
- 239000008280 blood Substances 0.000 claims abstract description 126
- 210000004369 blood Anatomy 0.000 claims abstract description 126
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims abstract description 93
- 229910052760 oxygen Inorganic materials 0.000 claims abstract description 92
- 239000001301 oxygen Substances 0.000 claims abstract description 92
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 28
- 238000005192 partition Methods 0.000 claims description 127
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 80
- 239000012510 hollow fiber Substances 0.000 claims description 16
- 235000012489 doughnuts Nutrition 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 8
- 239000007789 gas Substances 0.000 claims description 3
- 239000002245 particle Substances 0.000 claims description 2
- 238000009826 distribution Methods 0.000 claims 2
- 238000009792 diffusion process Methods 0.000 abstract description 11
- 238000010586 diagram Methods 0.000 description 14
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 10
- 230000004888 barrier function Effects 0.000 description 9
- 230000017531 blood circulation Effects 0.000 description 8
- 229910002092 carbon dioxide Inorganic materials 0.000 description 5
- 239000001569 carbon dioxide Substances 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000006213 oxygenation reaction Methods 0.000 description 4
- 210000004072 lung Anatomy 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000003491 array Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000037452 priming Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000010151 yanghe Substances 0.000 description 2
- 208000010496 Heart Arrest Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000000157 blood function Effects 0.000 description 1
- 238000013130 cardiovascular surgery Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000000287 tissue oxygenation Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3623—Means for actively controlling temperature of blood
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3666—Cardiac or cardiopulmonary bypass, e.g. heart-lung machines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0413—Blood
Landscapes
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pulmonology (AREA)
- External Artificial Organs (AREA)
Abstract
The present invention relates to a kind of membrane oxygenators comprising lower cover, oxygen conjunction portion and upper cover, lower cover have escape pipe；Oxygen conjunction portion is set to lower cover and closes shell and oxygen plying membrane structure including core shaft structure, oxygen, and oxygen, which closes shell, has blood vessel, and blood vessel is close to lower cover out；Upper cover is set to oxygen conjunction portion, and has turbulent structure, into blood vessel and oxygen feeding tube, and turbulent structure corresponds to core shaft structure；Wherein core shaft structure includes mandrel body and ring diversion plate, and mandrel body has first end and the second end, has blood channel between first end and turbulent structure, and ring diversion plate is sheathed on mandrel body.The core shaft structure of the membrane oxygenator of the application has ring diversion plate, and ring diversion plate guides blood diffusion, increases the contact area and diffusion area of blood and cortina structure, promotes the utilization rate of cortina structure.
Description
Technical field
The present invention relates to a kind of technical field of medical device product more particularly to a kind of membrane oxygenators.
Background technique
Membrane oxygenator is the medical instrument that cardiac arrest replaces lung, has and adjusts oxygen and carbon dioxide content in blood
Function, be the indispensable Medical Devices of cardiovascular surgery, and treatment acute respiratory illness and wait the lung transplantation stage indispensable
Medical Devices.Membrane oxygenator principle be will outside intracorporal venous blood lead body, after membrane oxygenator carry out oxygen and
Carbon dioxide exchange becomes arterial blood, then feeds back patient artery system, maintains the supply of human internal organ tissue oxygenation blood, is performing the operation
Temporarily substitution lung effect in the process, at the same for doctor provide peace and quiet, without blood, clearly surgical environments, in order to implement to perform the operation.
So the utilization rate of the cortina structure in current membrane oxygenator is not high, mainly not because of its blood water conservancy diversion diffuser efficiency
Good, blood is easy to be piled up in certain in membrane oxygenator, and only flows through from certain of cortina structure, and blood will not be from silk
The other positions of membrane structure flow through.
Summary of the invention
Aiming at the shortcomings in the prior art, the object of the present invention is to provide a kind of membrane oxygenators comprising: lower cover,
With escape pipe；Oxygen conjunction portion is set to the lower cover, and closes shell including core shaft structure, oxygen and be set to the mandrel knot
Structure and oxygen close the oxygen plying membrane structure between shell, and the oxygen, which closes shell, has blood vessel, and the blood vessel out is close to the lower cover；With
And upper cover, be set to oxygen conjunction portion, and with turbulent structure, be connected to the turbulent structure into blood vessel and oxygen feeding tube,
The turbulent structure corresponds to the core shaft structure, and the oxygen feeding tube and escape pipe are connected between the core shaft structure and oxygen conjunction shell
Space；Wherein the core shaft structure includes mandrel body and ring diversion plate, and the mandrel body has described in first end and connection
The second end of first end, has blood channel between the first end and turbulent structure, the ring diversion plate is sheathed on
The mandrel body.
Compared with prior art, the application can be obtained including following technical effect:
The application provides a kind of membrane oxygenator, is covered with turbulent structure thereon, and turbulent structure can avoid blood and directly flow
Enter core shaft structure, reduces blood and generate collision, avoid damage to the composition of blood.
The core shaft structure of the application has ring diversion plate, and ring diversion plate has flow-guiding structure, and flow-guiding structure guides blood
Liquid stream is dynamic, and shunts to blood, increases the diffusion area of blood, increases the contact area of blood and cortina structure, effectively mentions
The utilization rate of cortina structure is risen, while promoting the oxygenation efficiency of membrane oxygenator.
Detailed description of the invention
Fig. 1 is the perspective view of the membrane oxygenator of the application first embodiment.
Fig. 2 is the assembling figure of the membrane oxygenator of the application first embodiment.
Fig. 3 is the sectional view of the membrane oxygenator of the application first embodiment.
Fig. 4 is the schematic diagram of the turbulent structure of the application first embodiment.
Fig. 5 is the assembling figure of the membrane oxygenator of the application second embodiment.
Fig. 6 is the sectional view of the membrane oxygenator of the application second embodiment.
Fig. 7 is the schematic diagram of the core shaft structure of the application third embodiment
Fig. 8 is the schematic diagram of the annular partition of the 4th embodiment of the application.
Fig. 9 is the sectional view of the membrane oxygenator of the 5th embodiment of the application.
Figure 10 is the schematic diagram of the middle annular partition of the application sixth embodiment.
Figure 11 is the schematic diagram of the outer ring partition of the application sixth embodiment.
Figure 12 is the sectional view of the core shaft structure of the 7th embodiment of the application.
Figure 13 is the schematic diagram of the core shaft structure of the 8th embodiment of the application.
Figure 14 is the schematic diagram of the cortina structure of the 9th embodiment of the application.
Specific embodiment
Multiple embodiments of the application, as clearly stated, the details in many practices will be disclosed with schema below
It will be explained in the following description.It should be appreciated, however, that the details in these practices is not applied to limit the application.Also
It is to say, in some embodiments of the application, the details in these practices is non-essential.In addition, for the sake of simplifying schema,
Some known usual structures and component will be painted it in the drawings in simply illustrative mode.
About its " first " used herein, " second " etc., the meaning of order or cis-position is not especially censured, also non-use
The component described with limiting the application just for the sake of difference with same technique term or operation.
Fig. 1, Fig. 2, Fig. 3 and Fig. 4 are please referred to, is perspective view, the group of the membrane oxygenator 1 of the application first embodiment
The schematic diagram of dress figure, sectional view and turbulent structure 123；As shown, present embodiment provides a kind of membrane oxygenator 1, membrane type
Oxygenator 1 includes lower cover 10, oxygen conjunction portion 11 and upper cover 12, and oxygen conjunction portion 11 is set between lower cover 10 and upper cover 12.Lower cover 10 includes
The lower annular brace piece 102a of lower lid housing 101, first, the second lower annular brace piece 102b, escape pipe 103 and water inlet pipe 104, under
The lower annular sidewall 1012 that there is lid housing 101 lower surface 1011 and ring to set surface 1011.First lower annular brace piece 102a
And annular brace piece 102b is set to the lower surface 1011 of lower lid housing 101 under second, the second lower annular brace piece 102b is located at
The outside of first lower annular brace piece 102a, and be located in lower annular sidewall 1012, the diameter of the first lower annular brace piece 102a
The diameter of annular brace piece 102b lower less than second, the center of the first lower annular brace piece 102a, the second lower annular brace piece
The center of 102b and the center of lower cover 10 are located on same line, i.e., the first lower lower annular brace piece of annular brace piece 102a and second
102b is in making concentric arrays in lower lid housing 101.Escape pipe 103 is set to the lower surface 1011 of lower lid housing 101, and is connected to
Space between second lower annular brace piece 102b and lower annular sidewall 1012.Water inlet pipe 104 is set to lower annular sidewall 1012, and
Through lower annular sidewall 1012 and the second lower annular brace piece 102b, the lower annular brace piece 102b of the connection of water inlet pipe 104 second with
Space between first lower annular brace piece 102a.
Oxygen conjunction portion 11 includes core shaft structure 110, annular partition 111, oxygen conjunction shell 112, lower barrier structure 113, alternating temperature silk
Membrane structure 114, oxygen plying membrane structure 115 and upper barrier structure 116, core shaft structure 110 are set to the first lower annular brace piece
102a, and be located in the first lower annular brace piece 102a.Annular partition 111 is set to the second lower annular brace piece 102b, and position
In the outside of core shaft structure 110.Oxygen closes the lower annular sidewall 1012 that shell 112 is set to lower lid housing 101, and has blood vessel
1121 and circulating exhaust pipe 1122, for blood vessel 1121 close to lower cover 10, circulating exhaust pipe 1122 is located at 1121 top of blood vessel out, and
Far from lower cover 10, blood vessel 1121 and circulating exhaust pipe 1122 are connected to the space between core shaft structure 110 and oxygen conjunction shell 112 out.Under
Barrier structure 113 is arranged on core shaft structure 110 and is covered on lower cover 10, and is located at core shaft structure 110 and oxygen conjunction shell 112
Between.Alternating temperature cortina structure 114 is arranged in core shaft structure 110, and is set on lower barrier structure 113, and is located at core shaft structure 110
Between annular partition 111, temperature-varying zone is formed between such core shaft structure 110 and annular partition 111.Oxygen plying membrane structure 115 is worn
It in core shaft structure 110, and is set on lower barrier structure 113, and is located between annular partition 111 and oxygen conjunction shell 112, such ring
Shape partition 111 and oxygen form the area Yang He between closing shell 112.Upper barrier structure 116 is arranged on core shaft structure 110, and is set to
In alternating temperature cortina structure 114 and oxygen plying membrane structure 115, and it is located between core shaft structure 110 and oxygen conjunction shell 112.
The core shaft structure 110 of present embodiment includes mandrel body 1101 and ring diversion plate 1102, and mandrel body 1101 has
The outer diameter of the first end 1101a and the second end 1101b for connecting first end 1101a, the second end 1101b are greater than first end
The outer diameter of portion 1101a, the second end 1101b are set in the first lower annular brace piece 102a.Ring diversion plate 1102 is arranged in
Mandrel body 1101, and it is set to the first lower annular brace piece 102a of lower cover 10.There are ring diversion plate 1102 multiple water conservancy diversion to wear
Hole 11021, multiple water conservancy diversion perforation 11021 are uniformly distributed in ring diversion plate 1102.Each water conservancy diversion of present embodiment is perforated
11021 be bellmouth, is less than positioned at the aperture of the water conservancy diversion perforation 11021 of 1102 inside of ring diversion plate and is located at ring diversion plate
The aperture of the water conservancy diversion perforation 11021 in 1102 outsides.The water conservancy diversion perforation 11021 of certain present embodiment can also be straight hole, not in this
It repeats again.
The annular partition 111 of present embodiment has the multiple blood ports 1111 annularly arranged, multiple blood ports
1111 are used as flow-guiding structure, and multiple blood ports 1111 are close to lower cover 10.The annular partition 111 of present embodiment mainly reaches branch
The effect of support, and extend the path of blood diffusion increases connecing for blood and alternating temperature cortina structure 114 and oxygen plying membrane structure 115
Contacting surface product and diffusion area, the more utilization rate of promotion alternating temperature cortina structure 114 and oxygen plying membrane structure 115.
Upper cover 12 includes annular brace piece 122a on upper cover shell 121, first, annular brace piece 122b, vortex on second
Structure 123, into blood vessel 124, oxygen feeding tube 125 and outlet pipe 126, there is upper cover shell 121 upper surface 1211 and ring to set upper surface
1211 upper annular sidewall 1212.Annular brace piece 122b is set to upper cover shell on annular brace piece 122a and second on first
121 upper surface 1211, annular brace piece 122b is located at the outside of annular brace piece 122a on first, annular on first on second
Annular brace piece 122b is located in upper annular sidewall 1212 on support chip 122a and second, annular brace piece 122a and on first
The center of annular brace piece 122b and the center of upper cover shell 121 are located on same line on two.Turbulent structure 123 is set to upper cover
The center of shell 121, and be located on first in annular brace piece 122a, one end has blood inlet 1231, and the other end has
Blood outlet 1232.It is set to the upper annular sidewall 1212 of upper cover shell 121 into blood vessel 124, and through upper annular sidewall 1212, the
Annular brace piece 122a on annular brace piece 122b and first on two, and connect the blood inlet 1231 of turbulent structure 123.Oxygen feeding tube
125 are set to the upper annular sidewall 1212 of upper cover shell 121, and run through upper annular sidewall 1212, and with upper annular sidewall 1212
It is connected to the space of annular brace piece 122b on second.Outlet pipe 126 is set to the upper annular sidewall 1212 of upper cover shell 121,
And through annular brace piece 122b on upper annular sidewall 1212 and second, and it is connected on first on annular brace piece 122a and second
Space between annular brace piece 122b.
When upper cover 12 is set to oxygen conjunction portion 11, on first on annular brace piece 122a and second annular brace piece 122b in
Making concentric arrays in upper cover shell 121, the first lower annular brace piece 102a is corresponding with annular brace piece 122a on first, and second
Lower annular brace piece 102b is corresponding with annular brace piece 122b on second, the upper annular sidewall 1212 and lower cover of upper cover shell 121
The lower annular sidewall 1012 of shell 101 is corresponding, annular brace piece 122b on the upper annular sidewall 1212, second of upper cover shell 121
And the oxygen that annular brace piece 122a is arranged in oxygen conjunction portion 11 respectively on first closes shell 112, annular partition 111 and core shaft structure
110 ring diversion plate 1102.The center of lower cover 10, oxygen conjunction portion 11 and upper cover 12 is located on same line.Turbulent structure 123 goes out
The first end 1101a, the first end 1101a of mandrel body 1101 of the mandrel body 1101 of the corresponding core shaft structure 110 of blood mouth 1232
Outer diameter be less than the outer diameter of its second end 1101b, the first end 1101a of such mandrel body 1101 and ring diversion plate 1102
Between formed toward the blood access flowed outside core shaft structure 110, blood access is connected with the blood outlet 1232 of turbulent structure 123.
Space and upper cover between the lower annular brace piece 102b of the lower annular brace piece 102a and second of the first of lower lid housing 101
The corresponding core shaft structure 110 in space on the first of shell 121 between annular brace piece 122a and annular brace piece 122b on second with
Space between annular partition 111, the water inlet pipe 104 of lower cover 10 and the outlet pipe 126 of upper cover 12 are connected to core shaft structure 110 and annular
Space between partition 111.Space between the lower annular sidewall 1012 of lower lid housing 101 and the second lower annular brace piece 102b and on
The corresponding core shaft structure 110 in space between the upper annular sidewall 1212 of lid housing 121 and annular brace piece 122b on second is closed with oxygen
Space between shell 112, the oxygen feeding tube 125 of upper cover 12 and the escape pipe 103 of lower cover 10 are connected to core shaft structure 110 and oxygen closes shell
Space between 112.
The membrane oxygenator 1 of present embodiment in use, the blood of extracorporeal blood circuit device from membrane oxygenator 1
Enter turbulent structure 123 into blood vessel 124, blood enters the blood of mandrel body 1101 from the blood outlet 1232 of turbulent structure 123 again
Channel.Above-mentioned turbulent structure 123 can avoid blood and be directly entered oxygen conjunction portion 11, slow down blood enter mandrel body 1101 blood it is logical
The speed in road, while the flowing of blood is guided, it avoids blood from colliding, reduces blood by the chance destroyed.When blood enters blood
When liquid channel, blood flows from top to bottom along the outer surface of mandrel body 1101.Then blood is from the more of ring diversion plate 1102
A water conservancy diversion perforation 11021 flows to alternating temperature cortina structure 114, and plurality of water conservancy diversion perforation 11021 allows blood shunt, single a water conservancy diversion
Perforation 11021 in blood flow and its flow velocity reduce, from each water conservancy diversion perforation 11021 outflow blood can with easing up with change
Warm cortina structure 114 contacts；In addition to this, radial water conservancy diversion is reached by multiple water conservancy diversion perforation 11021, increases blood and alternating temperature silk
The contact area and diffusion area of membrane structure 114 improve the utilization rate of alternating temperature cortina structure 114, reduce the pressure of membrane oxygenator 1
Power, in other words, the ring diversion plate 1102 of present embodiment have the water conservancy diversion knot being made of multiple water conservancy diversion perforation 11021
Structure, to reach above-mentioned effect.
When blood enters alternating temperature cortina structure 114, while the water of modulated temperature is logical from the water inlet pipe 104 of lower cover 10
Enter, the water of modulated temperature is from 114 one end of alternating temperature cortina structure close to lower cover 10 toward the alternating temperature cortina structure close to upper cover 10
The flowing of 114 other ends is spread in the blood temperature of alternating temperature cortina structure 114 by the adjustment of its temperature.Diffuse to alternating temperature cortina knot
Structure 114 and the blood of adjusted temperature are flowed toward lower cover 10, then are flowed into from multiple blood ports 1111 of annular partition 111, blood
Liquid is spread toward oxygen plying membrane structure 115.
When blood flows into oxygen plying membrane structure 115, oxygen is inputted to annular brace piece 122b on second from oxygen feeding tube 125
The space between shell 112 is closed with oxygen, in other words, the oxygen of oxygen feeding tube 125 and the blood in oxygen plying membrane structure 115 carry out oxygen
It closes, replaces out the carbon dioxide in blood, oxygen generates carbon dioxide during closing, and carbon dioxide sinks down into lower cover 10, and under
The escape pipe 103 of lid 10 is discharged.The blood most closed afterwards through oxygen is discharged from the blood vessel 1121 that goes out that oxygen closes shell 112.
Above-mentioned alternating temperature cortina structure 114 and oxygen plying membrane structure 115 respectively include multilayer hollow fiber layer, in each layer
The section of the hollow fiber conduit of hollow fiber layer be it is round, rectangular or oval, every layer of doughnut is produced when rupturing
Gas from oxygen close shell 112 circulating exhaust pipe 1122 be discharged.Lower barrier structure 113 and the barrier of upper barrier structure 116 are located at
Blood in alternating temperature cortina structure 114 and oxygen plying membrane structure 115 is mobile toward lower cover 10 or upper cover 12.
Fig. 5 and Fig. 6 is please referred to, is the assembling figure and sectional view of the membrane oxygenator 1 of the application second embodiment；Such as
Shown in figure, the membrane oxygenator 1 of present embodiment is with the membrane oxygenator difference of above embodiment, present embodiment
Membrane oxygenator 1 omits the setting of temperature-varying zone, i.e. the second lower annular brace piece, ring of the water inlet pipe of omission lower cover 10, lower cover 10
Shape partition, upper cover 12 second on annular brace piece and the outlet pipe of upper cover 12 setting.Oxygen plying membrane structure 115 is directly arranged in
Between core shaft structure 110 and oxygen close shell 112, the escape pipe 103 of lower cover 10 and the oxygen feeding tube 125 of upper cover 12 are respectively communicated with mandrel knot
Structure 110 and oxygen close the space between shell 112, and such core shaft structure 110 and oxygen close the space between shell 112 and forms the area Yang He.
Referring to Fig. 7, it is the schematic diagram of the core shaft structure 110 of the application third embodiment；As shown, this implementation
The flow-guiding structure of the ring diversion plate 1102 of the core shaft structure 110 of mode includes multiple first water conservancy diversion perforation 11021a and multiple the
Two water conservancy diversion perforation 11021b, multiple first water conservancy diversion perforation 11021a are close to lower cover 10, i.e., it is distributed in ring diversion plate 1102
Lower section；Multiple second water conservancy diversion perforation 11021b are distributed in the top of ring diversion plate 1102, i.e., it is located at multiple first water conservancy diversion and wears
It perforates greater than multiple first water conservancy diversion in the aperture of the top of hole 11021a and close upper cover 12, multiple second water conservancy diversion perforation 11021b
The aperture of 11021a.
Referring to Fig. 8, it is the schematic diagram of the annular partition 111 of the 4th embodiment of the application；As shown, holding first
Embodiment, the outer surface of the annular partition 111 of present embodiment have flow-guiding structure, and flow-guiding structure is spaced multiple
Multiple spiral stream guidance slots 1112 of spiral stream guidance slot 1112, annular partition 111 are located at multiple blood ports of annular partition 111
1111 side or even one end of each spiral stream guidance slot 1112 are connected to corresponding blood port 1111.Each spiral is led
One end of chute 1112 and the horizontal circumferential length of its other end are greater than the semicircle perimeter of annular partition 111, in other words, each
A spiral stream guidance slot 1112 is more than the half-turn of annular partition 111；It is vertical between the both ends of each spiral stream guidance slot 1112
Distance between the annular partition 111 of half height and 2/3rds annular partition 111 height between.Annular partition
111 multiple spiral stream guidance slots 1112 guide blood flow, and spread and fill up multiple spiral stream guidance slots 1112, increase the expansion of blood
Area is dissipated, to come into full contact with oxygen plying membrane structure, increases the contact area and its utilization rate of oxygen plying membrane structure and blood.So
One end of each spiral stream guidance slot 1112 is connected to corresponding blood port 1111, and such blood is flowed into from multiple blood ports 1111
And multiple spiral stream guidance slots 1112 can be flowed into immediately, blood is rapidly full of entire spiral stream guidance slot 1112.
Referring to Fig. 9, it is the sectional view of the membrane oxygenator 1 of the 5th embodiment of the application；As shown, this implementation
The quantity of the annular partition of mode is two, and two annular partitions call middle annular partition 111a and outer ring partition 111b in the following text, in
The diameter of annular partition 111a is less than the diameter of outer ring partition 111b, and middle annular partition 111a is by the corresponding second lower annular branch
Annular brace piece 122b is fixed on blade 102b and second, outer ring partition 111b by lower lid housing 101 lower annular sidewall
1012 and upper cover shell 121 upper annular sidewall 1212 it is fixed, outer ring partition 111b is around oxygen plying membrane structure 115.This reality
The middle annular partition 111a and outer ring partition 111b for applying mode are respectively provided with 1111 groups of multiple blood ports of annular arrangement
At flow-guiding structure, setting position and the outer ring partition 111b's of multiple blood ports 1111 of middle annular partition 111a is multiple
The setting position of blood port 1111 is opposite, and multiple blood ports 1111 of the middle annular partition 111a of present embodiment are under
Lid 10, multiple blood ports 1111 of outer ring partition 111b are close to upper cover 12.The membrane oxygenator 1 of present embodiment increases ring
The quantity of shape partition, increases blood in alternating temperature cortina structure 114 and the diffusion length of oxygen plying membrane structure 115, with increase blood with
The contact area and diffusion area of multiple alternating temperature cortina structures 114 and oxygen plying membrane structure 115 improve alternating temperature cortina structure 114
And the utilization rate of oxygen plying membrane structure 115.In addition, multiple blood ports 1111 of outer ring partition 111b are far from blood vessel out
1121, avoid blood to the multiple blood ports 1111 connect from outer ring partition 111b from flowing directly into out blood vessel 1121, so more
Improve the utilization rate of alternating temperature cortina structure 114 and oxygen plying membrane structure 115.The surface of the outer ring partition 111b of present embodiment
It is further provided with the filter for removing blood particle and gas microembolus.
Figure 10 and Figure 11 is please referred to, is the schematic diagram and outer ring of the middle annular partition 111a of the application sixth embodiment
The schematic diagram of shape partition 111b；As shown, the 5th embodiment is held, the middle annular partition 111a and outer ring of present embodiment
Partition 111b is respectively provided with equally distributed multiple water conservancy diversion perforation 1113, because of annular partition 111a and outer ring in present embodiment
Shape partition 111b is respectively provided with multiple water conservancy diversion perforation 1113, therefore can be omitted middle annular partition 111a and outer ring partition 111b
Multiple blood ports setting.The aperture of multiple water conservancy diversion perforation 1113 of middle annular partition 111a is greater than the annular of core shaft structure
Deflector multiple water conservancy diversion perforation aperture, outer ring partition 111b multiple water conservancy diversion perforation 1113 aperture be less than it is middle annular every
Multiple water conservancy diversion perforation of the aperture of multiple water conservancy diversion perforation 1113 of plate 111a, middle annular partition 111a and outer ring partition 111b
1113 and ring diversion plate multiple water conservancy diversion perforation aperture be greater than 3mm.Certainly the setting of outer ring partition 111b can also be omitted,
Or outer ring partition 111b is identical as the outer ring partition of the 5th embodiment, repeats no more in this.
Multiple water conservancy diversion of middle annular partition 111a and outer ring partition 111b 1113 main guide blood flows of perforation, and will
Blood shunt, blood flow and its flow velocity in single a water conservancy diversion perforation 1113 reduce, from 1113 outflow of each water conservancy diversion perforation
Blood can be contacted with oxygen plying membrane structure with easing up.Each water conservancy diversion perforation of the middle annular partition 111a of right present embodiment
1113 be square hole, and such blood comes together in multiple water conservancy diversion perforation 1113 of middle annular partition 111a, is led for the multiple of square hole
Blood can be buffered by flowing through hole 1113.The position that corresponding oxygen closes the outer ring partition 111b for going out blood vessel 1121 of shell 112 is not provided with
Water conservancy diversion perforation 1113, that is, it is neighbouring go out blood vessel 1121 outer ring partition 111b water conservancy diversion perforation 1113 center and blood vessel out
The shortest distance at 1121 center is greater than 5mm, avoids blood directly from close to 1113 stream of multiple water conservancy diversion perforation for going out blood vessel 1121
Out, make blood that can improve the utilization rate of oxygen plying membrane structure from far from 1113 outflow of multiple water conservancy diversion perforation for going out blood vessel 1121, and
Blood is set uniformly to spread.
The inner surface of the middle annular partition 111a and outer ring partition 111b of present embodiment are further provided with spaced more
1113 difference of multiple water conservancy diversion perforation of a spiral stream guidance slot (as shown in figure 12), middle annular partition 111a and outer ring partition 111b
In multiple spiral stream guidance slots of middle annular partition 111a and outer ring partition 111b.Each spiral stream guidance grooved ring is around middle ring
It is more than the half-turn of the inner surface of shape partition 111a or outer ring partition 111b, in other words, one end of each spiral stream guidance slot
It is greater than the semicircle perimeter of middle annular partition 111a or outer ring partition 111b, each spiral shell to the horizontal circumferential length of its other end
Revolve diversion trench one end and its other end vertical range between half middle annular partition 111a or outer ring partition
The height of 111b with 2/3rds middle annular partition 111a or outer ring partition 111b height.
Figure 12 is please referred to, is the sectional view of the core shaft structure 110 of the 7th embodiment of the application；As shown, this reality
The inner surface for applying the ring diversion plate 1102 of the core shaft structure 110 of mode has spaced multiple spiral stream guidance slots 11022,
Multiple water conservancy diversion perforation 11021 are between multiple spiral stream guidance slots 11022, each spiral stream guidance slot 11022 is around annular water conservancy diversion
It is more than the half-turn of the inner surface of plate 1102, in other words, the level of one end of each spiral stream guidance slot 11022 to its other end
Circumferential length is greater than the semicircle perimeter of ring diversion plate 1102, one end and its other end of each spiral stream guidance slot 11022
Vertical range between the ring diversion plate 1102 of half height with 2/3rds ring diversion plate 1102 height.So
The first end 1101a of mandrel body 1101 has water conservancy diversion cambered surface 11011, and one end connection of each spiral stream guidance slot 11022 is led
Cambered surface 11011 is flowed, in other words, multiple spiral stream guidance slots 11022 are located at the side of the first end 1101a of mandrel body 1101,
And the second end 1101b of corresponding mandrel body 1101.The water conservancy diversion cambered surface 11011 of mandrel body 1101 can buffer the flow velocity of blood, and
Guiding blood is swimmingly flowed in blood channel, and blood will not accumulate the first end 1101a in mandrel body 1101.Right multiple spirals
Diversion trench 11022 is directly connected to water conservancy diversion cambered surface 11011, and water conservancy diversion cambered surface 11011 can directly guide blood to multiple spiral stream guidance slots
11022, blood quickly fills up multiple spiral stream guidance slots 11022, and multiple spiral stream guidance slots 11022 guide blood shunts and from ring
11021 outflow of multiple water conservancy diversion perforation of shape deflector 1102, multiple water conservancy diversion perforation 11021 of right ring diversion plate 1102 can be uniform
Ground by blood shunt, increases the contact area and diffusion area of blood and alternating temperature cortina structure again, increases alternating temperature cortina structure
Utilization rate.
Figure 13 is please referred to, is the schematic diagram of the core shaft structure 110 of the 8th embodiment of the application；As shown, this reality
The ring diversion plate 1102 for applying the core shaft structure 110 of mode is different from the ring diversion plate of above embodiment, present embodiment
Ring diversion plate 1102 have multiple blood ports 11023 and multiple spiral stream guidance slots 11022, multiple blood ports 11023
The first end 1101a of corresponding mandrel body 1101, multiple spiral stream guidance slots 11022 are arranged at intervals at the outer of ring diversion plate 1102
Surface, and it is located at the side of multiple blood ports 11023, while the second end 1101b of corresponding mandrel body 1101, this implementation
One end of each spiral stream guidance slot 11022 of mode is connected to corresponding blood port 11023, and connecting mandrel body 1101 is led
Flow cambered surface 11011.The horizontal circumferential length of one end of each spiral stream guidance slot 11022 to its other end is greater than ring diversion plate
1102 semicircle perimeter, one end of each spiral stream guidance slot 11022 and the vertical range of its other end are between half
The height of ring diversion plate 1102 with 2/3rds ring diversion plate 1102 height.When blood is from multiple blood ports
When 11023 inflow, blood rapidly flows into the multiple spiral stream guidance slots 11022 being connected to multiple blood ports 11023, increases blood
The contact area and diffusion area of liquid and alternating temperature cortina structure 114 increase the utilization rate of alternating temperature cortina structure 114.
The core shaft structure 110 of present embodiment can be used for above embodiment, when the core shaft structure 110 of present embodiment is answered
When for five embodiments, the circular direction of multiple spiral stream guidance slots 11022 of core shaft structure 110 and adjacent middle annular every
Surrounding for multiple spiral stream guidance slots of plate is contrary.
Figure 14 is please referred to, is the schematic diagram of the cortina structure 13 of the 9th embodiment of the application；As shown, this implementation
The cortina structure 13 of mode can be applied to the alternating temperature cortina structure and oxygen plying membrane structure of above embodiment comprising in multilayer
Hollow fiber layer 131, each layer of doughnut layer 131 have multiple hollow fiber conduits 1311, and multiple hollow fiber conduits 1311 are opposite
In one angle of vertical plane, the inclined direction of multiple hollow fiber conduits 1311 of each layer of doughnut layer 131 and adjacent
The inclined direction of multiple hollow fiber conduits 1311 of doughnut layer 131 is different, in other words, wherein one layer of doughnut layer
Multiple hollow fiber conduits 1311 of 131 multiple hollow fiber conduits 1311 and another layer of doughnut layer 131 intersect, often
The hollow fiber conduit 1311 of one layer of doughnut layer 131 and the angle of vertical plane are 15 degree.Each layer of doughnut layer 131
Hollow fiber conduit 1311 section be ellipse, can so reduce blood priming amount.When blood flows into cortina structure 13
At 131, two adjacent doughnut layer, blood can be split into thinner blood film, increase the contact area of blood and oxygen,
Promote the oxygenation efficiency of blood and oxygen.
The ring diversion plate of above embodiment, annular partition, middle annular partition and the water conservancy diversion perforation of outer ring partition, blood
The quantity of liquid port or spiral stream guidance slot is one.In addition, the center of the water conservancy diversion perforation of the neighbouring middle annular partition 111 of blood vessel out
It is greater than 5mm with the shortest distance at the center of blood vessel out.
In conclusion the application provides a kind of membrane oxygenator, it is covered with turbulent structure thereon, turbulent structure can avoid blood
Liquid flows directly into core shaft structure, reduces blood and generates collision, avoids damage to the composition of blood.The core shaft structure of right the application has
Ring diversion plate, ring diversion plate have flow-guiding structure, and flow-guiding structure guides blood flow, and shunts to blood, increases blood
The diffusion area of liquid increases the contact area of blood and cortina structure, effectively promotes the utilization rate of cortina structure, while promoting film
The oxygenation efficiency of formula oxygenator.At least one settable annular partition of the membrane oxygenator of the application, annular partition can support film
Formula oxygenator, while there is flow-guiding structure, the flow-guiding structure effect having the same with ring diversion plate thereon.The silk of the application
The spacing of the adjacent two layer doughnut layer of membrane structure is small, can shunt again to blood, blood is made to form relatively thin blood film,
The oxygenation efficiency of blood and oxygen is allowed to be promoted.The section of the hollow fiber conduit of each layer of doughnut layer be it is round, rectangular or
Ellipse can so reduce the priming volume of blood.
The upper only presently filed embodiment, is not intended to limit this application.For those skilled in the art
For, various changes and changes are possible in this application.All any modifications made in spirit herein and principle are equal
Replacement, improvement etc., should all be included within the scope of the claims of the present application.
Claims (14)
1. a kind of membrane oxygenator characterized by comprising
Lower cover, with escape pipe；
Oxygen conjunction portion is set to the lower cover, and closes shell including core shaft structure, oxygen and be set to the core shaft structure and oxygen conjunction
Oxygen plying membrane structure between shell, the oxygen, which closes shell, has blood vessel, and the blood vessel out is close to the lower cover；And
Upper cover, is set to oxygen conjunction portion, and with turbulent structure, be connected to the turbulent structure into blood vessel and into oxygen
Pipe, the turbulent structure correspond to the core shaft structure, and the oxygen feeding tube and escape pipe are connected to the core shaft structure and oxygen closes shell
Between space；
Wherein the core shaft structure includes mandrel body and ring diversion plate, and the mandrel body has first end and connection described the
The second end of one end, has blood channel between the first end and turbulent structure, the ring diversion plate is sheathed on institute
Mandrel body is stated, and the surface of the ring diversion plate is provided at least one spiral stream guidance slot；
Wherein the ring diversion plate also has the perforation of at least one water conservancy diversion, at least one water conservancy diversion perforation of the ring diversion plate
It is distributed on the ring diversion plate.
2. membrane oxygenator according to claim 1, which is characterized in that at least one water conservancy diversion of the ring diversion plate is worn
Hole include at least one first water conservancy diversion perforation and at least one second water conservancy diversion perforation, the ring diversion plate at least one first
Water conservancy diversion is perforated close to the lower cover, at least one second water conservancy diversion perforation of the ring diversion plate is located at the ring diversion plate
The top of at least one first water conservancy diversion perforation, and close to the upper cover, at least one second water conservancy diversion of the ring diversion plate is worn
The aperture in hole is greater than the aperture that at least one first water conservancy diversion of the ring diversion plate is perforated.
3. membrane oxygenator according to claim 1, which is characterized in that at least one spiral of the ring diversion plate is led
Chute is set to the inner surface of the ring diversion plate, at least one water conservancy diversion perforation of the ring diversion plate is located at the annular
In at least one spiral stream guidance slot of deflector, at least one spiral stream guidance slot of the ring diversion plate corresponds to the mandrel body
The second end, one end connects the first end of the mandrel body.
4. membrane oxygenator according to claim 1, which is characterized in that the ring diversion plate also has annular arrangement
At least one blood port, at least one blood port of the ring diversion plate correspond to the first end of the mandrel body, institute
At least one the spiral stream guidance slot for stating ring diversion plate is set to the outer surface of the ring diversion plate, and is located at the annular and leads
The side of at least one blood port of flowing plate.
5. membrane oxygenator according to claim 1, which is characterized in that the first end of the mandrel body has water conservancy diversion arcs
Face.
6. membrane oxygenator according to claim 1, which is characterized in that further include at least one annular partition, it is described extremely
A few annular partition is set between the core shaft structure and oxygen conjunction shell, and the lower cover has water inlet pipe, and the upper cover has
Outlet pipe, the water inlet pipe and outlet pipe are connected to the sky between the annular partition and the core shaft structure of the core shaft structure
Between；The oxygen feeding tube and escape pipe are connected to the space closed between shell close to the annular partition of the core shaft structure and the oxygen；It leans on
It is equipped with alternating temperature cortina structure between the annular partition and the core shaft structure of the nearly core shaft structure, close to the ring of the core shaft structure
Shape partition and the oxygen are equipped with oxygen plying membrane structure between closing shell.
7. membrane oxygenator according to claim 6, which is characterized in that the alternating temperature cortina structure and oxygen plying membrane structure
Multilayer hollow fiber layer is respectively included, each layer of doughnut layer has multiple hollow fiber conduits, each hollow fiber conduit
Section is round, rectangular or oval.
8. membrane oxygenator according to claim 6 or 7, which is characterized in that each annular partition has at least one
Water conservancy diversion perforation, at least one water conservancy diversion perforation distributions of each annular partition are in corresponding annular partition.
9. membrane oxygenator according to claim 8, which is characterized in that each described annular partition further includes at least one
A spiral stream guidance slot, at least one spiral stream guidance slot of each described annular partition are set to the interior table of corresponding annular partition
Face, at least one spiral that at least one water conservancy diversion perforation of each annular partition is located at the corresponding annular partition are led
In chute.
10. membrane oxygenator according to claim 6 or 7, which is characterized in that during at least one described annular partition includes
Annular partition and outer ring partition, the outer ring partition are set to the outside of the middle annular partition, the outer ring partition
The neighbouring oxygen closes shell, and the middle annular partition and outer ring partition are respectively provided with the perforation of at least one water conservancy diversion, the middle ring
At least one water conservancy diversion perforation distributions of shape partition are perforated in the middle annular partition, at least one water conservancy diversion of the outer ring partition
It is distributed in the outer ring partition.
11. membrane oxygenator according to claim 10, which is characterized in that the surface setting of the outer ring partition is useful
In the filter of removal blood particle and gas microembolus.
12. membrane oxygenator according to claim 10, which is characterized in that the middle annular partition and outer ring partition are also
At least one spiral stream guidance slot is respectively included, at least one spiral stream guidance slot of the middle annular partition is arranged at intervals in described
At least one spiral stream guidance slot of the inner surface of annular partition, the outer ring partition is arranged at intervals at the outer ring partition
At least one water conservancy diversion perforation of inner surface, the middle annular partition and outer ring partition is located at the middle annular partition and outer
In at least one spiral stream guidance slot of annular partition.
13. membrane oxygenator according to claim 10, which is characterized in that it is neighbouring described go out blood vessel the middle annular every
The center of at least one water conservancy diversion of plate and/or outer ring partition perforation and the shortest distance at the center of blood vessel out are greater than
5mm。
14. membrane oxygenator according to claim 6 or 7, which is characterized in that each annular partition includes annular arrangement
At least one blood port and at least one spiral stream guidance slot, close to the core shaft structure annular partition at least one blood
For liquid port close to the lower cover, at least one spiral stream guidance slot of each annular partition is set to the outer of corresponding annular partition
Surface, and it is located at the side of at least one blood port.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710817386.9A CN107485744B (en) | 2017-09-12 | 2017-09-12 | A kind of membrane oxygenator |
| PCT/CN2017/101885 WO2019051772A1 (en) | 2017-09-12 | 2017-09-15 | Membrane oxygenator |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710817386.9A CN107485744B (en) | 2017-09-12 | 2017-09-12 | A kind of membrane oxygenator |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN107485744A CN107485744A (en) | 2017-12-19 |
| CN107485744B true CN107485744B (en) | 2019-08-30 |
Family
ID=60652105
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710817386.9A Active CN107485744B (en) | 2017-09-12 | 2017-09-12 | A kind of membrane oxygenator |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN107485744B (en) |
| WO (1) | WO2019051772A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109224163B (en) * | 2018-10-16 | 2019-06-21 | 广东工业大学 | A kind of hollow fiber membrane oxygenator that heat exchange layers are external |
| EP3669971B1 (en) * | 2018-12-21 | 2024-05-22 | Gambro Lundia AB | Diffusion device |
| EP4045105A1 (en) | 2019-10-15 | 2022-08-24 | CardiacAssist, Inc. | Oxygenator with wound filter membrane and flow diffuser |
| CN111494741B (en) * | 2020-05-25 | 2024-08-09 | 北京清瀚医疗科技有限公司 | Artificial lung for extracorporeal circulation |
| WO2024121590A1 (en) * | 2022-12-05 | 2024-06-13 | Divigas Pte Ltd | Hollow fiber membrane module for hydrogen separation |
| CN116850361A (en) * | 2023-02-14 | 2023-10-10 | 深圳汉诺医疗科技有限公司 | Oxygenator lower cover structure, oxygenator shell and oxygenator |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104220106A (en) * | 2011-01-27 | 2014-12-17 | 美敦力公司 | Wound heat exchanger |
| CN204699119U (en) * | 2015-05-13 | 2015-10-14 | 珠海健帆生物科技股份有限公司 | Blood purification consumptive material and end cap thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4411783A (en) * | 1981-12-23 | 1983-10-25 | Shiley Incorporated | Arterial blood filter with improved gas venting |
| CN2277783Y (en) * | 1996-06-27 | 1998-04-08 | 西安西京医疗用品有限公司 | Nembrane type oxyenator |
| CN2339228Y (en) * | 1998-02-26 | 1999-09-22 | 寿锡健 | Diaphragm type oxygenator capable of throwing away wholly |
| CN2772515Y (en) * | 2004-04-23 | 2006-04-19 | 广东省医疗器械研究所 | Hollow fibrous coat oxygenator |
| CN201192486Y (en) * | 2008-04-28 | 2009-02-11 | 东莞科威医疗器械有限公司 | Oxygenation chamber structure of film oxygenator |
| CN201510571U (en) * | 2009-09-29 | 2010-06-23 | 山东威高新生医疗器械有限公司 | Membrane type oxygenator |
| US8518259B2 (en) * | 2011-01-27 | 2013-08-27 | Medtronic, Inc. | De-airing oxygenator for treating blood in an extracorporeal blood circuit |
| US8685319B2 (en) * | 2011-04-29 | 2014-04-01 | Medtronic, Inc. | Combination oxygenator and arterial filter device with a fiber bundle of continuously wound hollow fibers for treating blood in an extracorporeal blood circuit |
| US10286137B2 (en) * | 2013-05-17 | 2019-05-14 | Novalung Gmbh | Oxygenator module, oxygenator and production method |
| CN204364532U (en) * | 2014-12-13 | 2015-06-03 | 西安西京医疗用品有限公司 | A kind of membrane oxygenator |
| CN105833373A (en) * | 2016-06-13 | 2016-08-10 | 北京米道斯医疗器械有限公司 | Hollow fiber membrane oxygenator and method |
-
2017
- 2017-09-12 CN CN201710817386.9A patent/CN107485744B/en active Active
- 2017-09-15 WO PCT/CN2017/101885 patent/WO2019051772A1/en active Application Filing
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104220106A (en) * | 2011-01-27 | 2014-12-17 | 美敦力公司 | Wound heat exchanger |
| CN204699119U (en) * | 2015-05-13 | 2015-10-14 | 珠海健帆生物科技股份有限公司 | Blood purification consumptive material and end cap thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN107485744A (en) | 2017-12-19 |
| WO2019051772A1 (en) | 2019-03-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN107485744B (en) | A kind of membrane oxygenator | |
| CN208893292U (en) | A kind of spiral stream guidance integrated form membrane oxygenator | |
| CN107432960B (en) | Spiral diversion integrated film type oxygenator | |
| CN107362399B (en) | Spiral diversion integrated film type oxygenator | |
| CN111032106B (en) | Dual chamber gas exchanger for respiratory support | |
| US6454999B1 (en) | Integrated blood pump and oxygenator system having extended blood flow path | |
| US7338521B2 (en) | Low profile inlet for an implantable blood pump | |
| US4282180A (en) | Blood oxygenator | |
| US4440723A (en) | Blood oxygenator | |
| CN105899245B (en) | The blood treatment unit of heat exchanger core with the flow path for providing modification | |
| EP0035266A1 (en) | A device for the transfer of one or more substances between a gas and a liquid | |
| CN107638601B (en) | Silk membrane structure and membrane oxygenator | |
| CN113398354B9 (en) | Integrated membrane oxygenator | |
| JP2018518236A (en) | Blood gas exchanger having one or more limiting elements for reducing gas exchange | |
| CN208770516U (en) | A kind of double helix water conservancy diversion integrated form membrane oxygenator | |
| WO2024169708A1 (en) | Lower cover structure of oxygenator, oxygenator housing and oxygenator | |
| CN116212139A (en) | Oxygenator upper cover structure, oxygenator shell and oxygenator | |
| CN112546321B (en) | Membrane oxygenator | |
| CN117122814B (en) | Pump head oxygenator assembly and extracorporeal membrane pulmonary oxygenation system | |
| CN115607759B (en) | Blood oxygenator | |
| US20240165310A1 (en) | Blood processing unit (bpu) with countercurrent blood/water flow paths in the heat exchanger (hex) | |
| CN113413504B (en) | Multi-chamber oxygenator with liquid separation drainage structure | |
| CN101262931A (en) | Paracorporeal respiratory assist lung | |
| CN117563071A (en) | Vertical oxygenation equipment | |
| CN111298287B (en) | Bionic ECMO equipment for external life support |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |