CN205653465U - Nucleic acid extraction apparatus - Google Patents
Nucleic acid extraction apparatus Download PDFInfo
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- CN205653465U CN205653465U CN201620244432.1U CN201620244432U CN205653465U CN 205653465 U CN205653465 U CN 205653465U CN 201620244432 U CN201620244432 U CN 201620244432U CN 205653465 U CN205653465 U CN 205653465U
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- nucleic acid
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- seat
- extracting apparatus
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Abstract
The utility model belongs to medical equipment field provides the nucleic acid extraction apparatus that can supply to extract after the schizolysis nucleic acid in the blood, be in including mobilizable first supporting seat, connection a plurality of bar magnet subassemblies on the first supporting seat, can supply with the bar magnet subassembly removes the complex thimble assembly to and can supply the schizolysis groove of schizolysis blood, the lower extreme joinable of thimble assembly is in the schizolysis inslot, the bar magnet subassembly includes telescopic coupling assembling, but coupling assembling's end butt is in in the thimble assembly, the nucleic acid extraction apparatus of design can solve terminal unable butt simultaneously to the sheathed tube bottom of bar magnet structure in the current device like this, and then leads to the problem of nucleic acid extraction efficiency reduction.
Description
Technical field
This utility model belongs to medical equipment field, particularly relates to a kind of nucleic acid-extracting apparatus.
Background technology
Instrument for extracting nucleic acid, is to apply supporting nucleic acid extracting reagent to be automatically performed the extraction work of sample nucleic acid
Instrument, existing instrument for extracting nucleic acid is divided into two classes: a class is large-scale automatization, commonly referred to as automatically
Liquid working station；Another kind of is small-sized automatic instrument for extracting nucleic acid, utilizes packaged matched reagent to be automatically performed
Extraction purification process.Large-scale automated fluid work station is because equipment cost is high, and operating cost is high, is suitable for one
Thousand of one species specimen of secondary extraction, so be really applied is fewer；And the instrument of small automatic
Device, because instrument and equipment and operating cost are low, easy to operate is more and more applied, existing small-sized
The bar magnet structure that the instrument amplifying nucleic acid of automatization is extracted is when drawing nucleic acid, often due to multiple bar magnet structure is long
The relation of degree, its end cannot abut to sleeve bottom simultaneously, and then causes the quantity of nucleic acid extraction few, with
As for the efficiency affecting nucleic acid extraction.
Utility model content
The purpose of this utility model is to provide a kind of nucleic acid-extracting apparatus, it is intended to solve magnetic in existing device
The end of bar structure cannot abut to the bottom of sleeve pipe simultaneously, and then causes the problem that nucleic acid extraction efficiency reduces.
This utility model is so to solve: a kind of nucleic acid-extracting apparatus, is available for extracting after cracking in blood
Nucleic acid, the multiple bar magnet assemblies including moveable first support seat, being connected on described first support seat,
It is available for moving with described bar magnet assembly the thimble assembly coordinated, and is available for cracking the splitter of blood, described
The lower end of thimble assembly is attached in described splitter, and described bar magnet assembly includes telescopic connection assembly,
The end of described connection assembly can be connected in described thimble assembly.
Further, described bar magnet assembly also include spring part, described connection assembly include the first connector and
Second connector, described second connector elasticity is connected on described first connector, and described spring part is even
It is connected in described first connector.
Further, described first connector upper end is vertically connected on described first and supports on seat, and described the
Being provided with connection chamber in a connection piece, the opening in described connection chamber is positioned at the lower end of described first connector, and institute
Stating the cross-sectional area cross-sectional area less than described connection chamber of opening, described spring part is connected to described connection chamber
In.
Further, described second connector includes that the described limiting section of limiting section, magnetic part and connection is with described
The connecting rod of magnetic part, described limiting section connects described connection intracavity, and the end of described limiting section abuts institute
Stating the free end of spring part, described connecting rod mobile link is at described connection intracavity.
Further, described second connector is work shape structure, and the cross-sectional area of described connecting rod is less than institute
State cross-sectional area and the cross-sectional area of described magnetic part of limiting section.
Further, described thimble assembly includes mounting bar and the multiple suctions being vertically connected on described mounting bar
Attached pipe, the opening of multiple described adsorption tubes is arranged on described mounting bar, described bar magnet assembly mobile link
In described adsorption tube, and single described magnetic part can move the bottom abutting to single described adsorption tube.
Further, described nucleic acid-extracting apparatus also includes that moveable second supports seat, and described second supports
Offer on seat and be available for the mounting groove that described mounting bar is slidably installed, described mounting groove by described support seat portion to
Upper depression is formed.
Further, described second support seat is further opened with being available for multiple through holes that described bar magnet assembly passes,
Multiple described through holes and the opening one_to_one corresponding on described mounting bar.
Further, described first support be also associated with on seat driving described first to support seat moves up and down the
One drives assembly, and described second supports be also associated with driving described second support seat to move up and down on seat second
Drive assembly.
Further, described nucleic acid-extracting apparatus also includes that base, described splitter are positioned on described base,
Described first supports seat is connected to the described second top supporting seat, and described second supports seat is positioned at described cracking
The top of groove.
The technique effect that the nucleic acid-extracting apparatus that this utility model provides has relative to existing device is: logical
Cross moveable first and support seat and the multiple bar magnet assemblies being connected on this first support seat, and sleeve pipe group
The setting of part, this first support seat drive the telescopic connection assembly on bar magnet assembly to move and with sleeve pipe group
Part coordinates, wherein during the first support seat drives bar magnet assembly to move, owing to connecting the end of assembly
The bottom of thimble assembly, and the scalability of this connection assembly can be connected to, and then can ensure that multiple company
The end of connected components can the simultaneously elastic bottom being connected to thimble assembly, and then ensure that in splitter
Nucleic acid sufficiently adsorbs on thimble assembly, thus improves the purification efficiency of nucleic acid.
Accompanying drawing explanation
Fig. 1 is the structure chart one of the nucleic acid-extracting apparatus that this utility model embodiment provides.
Fig. 2 is the structure chart two of the nucleic acid-extracting apparatus that this utility model embodiment provides.
Fig. 3 is the structure chart of the nucleic acid-extracting apparatus middle sleeve assembly that this utility model embodiment provides.
Fig. 4 is the structure chart of bar magnet assembly in the nucleic acid-extracting apparatus that this utility model embodiment provides.
Fig. 5 is the sectional side elevation of bar magnet assembly in the nucleic acid-extracting apparatus that this utility model embodiment provides.
Detailed description of the invention
In order to make the purpose of this utility model, technical scheme and advantage clearer, below in conjunction with accompanying drawing
And embodiment, this utility model is further elaborated.Should be appreciated that described herein specifically
Embodiment, only in order to explain this utility model, is not used to limit this utility model.
It should be noted that when element is referred to as " being fixed on " or " being arranged at " another element, and it is permissible
Directly on another element or may be simultaneously present centering elements.When an element is known as " being connected to "
Another element, it can be directly to another element or may be simultaneously present centering elements.
Also, it should be noted the orientation term such as left and right, upper and lower in this utility model embodiment, only
It is relative concept or with the normal operating condition of product as reference each other, and should not be regarded as that there is limit
Property processed.
Refer to shown in accompanying drawing 1 and Fig. 2, in this utility model embodiment, it is provided that one is available for extraction and splits
The nucleic acid-extracting apparatus of nucleic acids in blood after solution, this device includes moveable first support seat 10, is connected to
This first support on seat 10 multiple be arranged in juxtaposition bar magnet assembly 20, be available for moving with multiple bar magnet assemblies 20
The dynamic thimble assembly 30 coordinated, and be available for cracking the splitter 50 of blood, simultaneously this thimble assembly 30
Lower end is connected in splitter 50, and this bar magnet assembly 20 includes telescopic connection assembly, this connection assembly
End can be connected in thimble assembly 30.This connection assembly preferably includes to be mutually shifted the first connection of connection
Part 201 and the second connector 202, the end of this second connector 202 moves and is connected to this thimble assembly 30
Bottom, and the end of the second connector 202 of multiple bar magnet assembly 20 can move simultaneously abutting sleeve pipe group
The bottom of part 30；
During work, carry out cracking in first sample to be cracked is placed into splitter 50 and separate, in the mistake of cracking
Cheng Zhong, the nanoscale magnetic particle meeting discharged in this splitter 50 and nucleic acid absorption, then by thimble assembly 30
Install and move the bottom of the lower end abutting splitter 50 to thimble assembly 30, support seat 10 followed by first
The magnetic end driving multiple bar magnet assembly 20 being arranged in juxtaposition to be moved downward to the second connector 202 is connected to
The bottom of thimble assembly 30, connects due to elastic between the first connector 201 and the second connector 202, enters
And after some second connector 202 first abuts to the bottom of thimble assembly 30, have no effect on other
The end of two connectors 202 abuts to the bottom of thimble assembly 30；Then the core of nanoscale magnetic particle has been adsorbed
Acid can be adsorbed on the outer wall of thimble assembly 30, this completes the extraction of nucleic acid；In this process,
As traditional technology is owing in bar magnet assembly 20 manufacturing process, length cannot be accurate to completely, and then cannot protect
The magnetic end demonstrate,proving all of bar magnet assembly 20 can abut to the bottom of thimble assembly 30, Jin Erwu simultaneously
The efficient purifying nucleic acid of method.
The nucleic acid-extracting apparatus more than designed, supports seat 10 by moveable first and is connected to this first
Multiple bar magnet assemblies 20 on support seat 10, and the setting of thimble assembly 30, this first support seat 10 carries
Dynamic bar magnet assembly 20 moves and coordinates with thimble assembly 30, wherein supports seat 10 first and drives bar magnet assembly
During 20 move, owing to the second connector 202 can be connected to the bottom of thimble assembly 30, and should
First connector 201 is connected with the second connector 202 elasticity, and then can ensure that multiple second connector 202
End can the simultaneously elastic bottom being connected to thimble assembly 30, and then ensure that in splitter 50
Nucleic acid sufficiently adsorbs on thimble assembly 30, thus improves the purification efficiency of nucleic acid.
In the present embodiment, the multiple bar magnet assemblies 20 being connected on the first support seat 10 can be to become side by side
One row, it is also possible to be multiple rows of side by side, and the quantity of this thimble assembly 30 and splitter 50 and arrange with many
This bar magnet assembly 20 individual is corresponding, selects with specific reference to practical situation, and so design can be at first
Support seat 10 moves the nucleic acid can withdrawn deposit successively in multiple splitter 50, and then can improve nucleic acid further
Purification efficiency.
Specifically, as shown in Figure 4 and Figure 5, in this utility model embodiment, this bar magnet assembly 20 also wraps
Include the spring part 203 being connected in the first connector 201；This first connector 201 upper end is vertically connected on
On first bottom supporting seat 10, and being additionally provided with connection chamber 2011 in this first connector 201, this is even
The opening 2012 connecing chamber 2011 is positioned at the lower end of the first connector 201, and the cross-sectional area of opening 2012 is little
In the cross-sectional area in connection chamber 2011, this spring part 203 is connected to connect in chamber 2011 simultaneously, should herein
Spring part 203 is preferably and is vertically placed in this connection chamber 2011, and this second connector 202 includes limit simultaneously
Position portion 2021, magnetic part 2023 and connection limiting section 2021 and the connecting rod 2022 of magnetic part 2023, be somebody's turn to do
Limiting section 2021 is connected to connect in chamber 2011, and the end of this limiting section 2021 abuts spring part 203
Free end, and one end that this limiting section is connected with this connecting rod 2022 can be connected to the interior of opening 2012
Side.
In the present embodiment, this first connector 201 and the second connector 202 are both preferably column structure,
This first connector 201 is vertically connected on the bottom of this first support seat 10, and then this first support seat 10
The first connector 201 is driven vertically to move when moving up and down, the limiting section on this second connector 202 top
In the 2021 spacing connection chambeies 2011 being connected to the first connector 201, and this spring part 203 is connected to
In this connection chamber 2011 and be connected to the end of limiting section 2021, thus when some this second connector 202
When the magnetic part 2023 of lower end abuts the bottom of thimble assembly 30, this first support seat 10 can drive first
Connector 201 continues to move down a certain distance, and then ensures that all of magnetic part 2023 all abuts to set
The bottom of pipe assembly 30, in this process, spring part 203 is compressed, and after nucleic acid has been drawn, should
First supports on seat 10 after shifting, and this spring part 203 restores to the original state.
Specifically, as shown in Figure 4 and Figure 5, in this utility model embodiment, this second connector 202
It is preferably H-column shape structure, and the cross-sectional area being positioned at connecting rod 2022 in the middle part of the second connector 202 is little
Limiting section 2021 and the cross-sectional area of magnetic part 2023 in two ends.
In the present embodiment, this spacing mobile link of limiting section 2021 is in the connection chamber of the first connector 201
In 2011, owing to connecting the cross-sectional area cross-sectional area more than limiting section 2021 in chamber 2011, limiting section 2021
Cross-sectional area more than connecting the cross-sectional area of chamber 2011 opening 2012, connect the opening 2012 in chamber 2011
Cross-sectional area more than the cross-sectional area of connecting rod 2022；And then spring part 203 is when being compressed, this limiting section
2021 move up in this connection chamber 2011, and when spring part 203 recovers, this limiting section 2021 with
Connecting rod 2022 junction is connected on the opening 2012 in this connection chamber 2011.
Specifically, as shown in Figure 1, Figure 2 and Figure 3, in this utility model embodiment, this thimble assembly
30 include mounting bar 301 and the multiple adsorption tubes 302 being connected to vertically downward on this mounting bar 301, multiple
The distribution of adsorption tube 302 is corresponding with the distribution of multiple bar magnet assemblies 20, and the opening of multiple adsorption tube 302
3021 are arranged on mounting bar 301, and this bar magnet assembly 20 can move in this adsorption tube 302, and
Single magnetic part 2023 can move the bottom abutting to single adsorption tube 302.
In the present embodiment, be parallel to each other between multiple adsorption tubes 302, and this mounting bar 301 and absorption
Pipe 302 is preferably one and becomes to mould, and this thimble assembly 30 is preferably detachably connected on bar magnet assembly 20
Lower section；And it is additionally provided with easy-to-dismount Handheld Division 3011 on this mounting bar 301.
Specifically, as depicted in figs. 1 and 2, in this utility model embodiment, this nucleic acid-extracting apparatus is also
Supporting seat 40 including moveable second, this second supports to offer on seat 40 and is available for mounting bar 301 and slides
The mounting groove 402 installed, this mounting groove 402 is upwards caved in by support seat portion and is formed, this external this second
Be further opened with being available for, on support seat 40, multiple through holes 401 that bar magnet assembly 20 passes, these through holes 401 multiple with
Opening 3021 one_to_one corresponding on mounting bar 301, supports first simultaneously and is also associated with driving the on seat 10
One supports the first driving assembly 70 that seat 10 moves up and down, and supports second and is also associated with driving the on seat 40
Two support the second driving assembly 80 that seat 40 moves up and down.
In the present embodiment, first thimble assembly 30 is arranged on the second support seat 40 by mounting bar 301
In the mounting groove 402 offered, then support seat 40 together with sleeve pipe group by the second driving assembly 80 by second
Part 30 is moved downward to the bottom contact of adsorption tube 302 or the bottom close to splitter 50, then first drives
Dynamic assembly 70 drives this first support seat 10 to move down, until being connected to the magnetic bottom the first support seat 10
Magnetic part 2023 bottom rod assembly 20 abuts to bottom the inwall of corresponding adsorption tube 302, and then
By magnetic part 2023, nanoscale magnetic particle is adsorbed on the outer wall of adsorption tube 302, and then by nucleic acid purification.
Specifically, as depicted in figs. 1 and 2, in this utility model embodiment, this nucleic acid-extracting apparatus is also
Including base 60, this splitter 50 is positioned on base 60, and this first support seat 10 is connected to second
Supporting the top of seat 40, this second support seat 40 is positioned at the top of splitter 50 simultaneously.
The foregoing is only preferred embodiment of the present utility model, not in order to limit this utility model,
All any amendment, equivalent and improvement etc. made within spirit of the present utility model and principle, all should
Within being included in protection domain of the present utility model.
Claims (10)
1. a nucleic acid-extracting apparatus, it is available for the nucleic acid in blood after extraction cracks, it is characterized in that: include moveable first support seat, the multiple bar magnet assemblies being connected on described first support seat, be available for moving, with described bar magnet assembly, the thimble assembly coordinated, and it is available for cracking the splitter of blood, the lower end of described thimble assembly is attached in described splitter, described bar magnet assembly includes that telescopic connection assembly, the end of described connection assembly can be connected in described thimble assembly.
2. nucleic acid-extracting apparatus as claimed in claim 1, it is characterized in that: described bar magnet assembly also includes spring part, described connection assembly includes the first connector and the second connector, described second connector elasticity is connected on described first connector, and described spring part is connected in described first connector.
3. nucleic acid-extracting apparatus as claimed in claim 2, it is characterized in that: described first connector upper end is vertically connected on described first and supports on seat, and in described first connector, it is provided with connection chamber, the opening in described connection chamber is positioned at the lower end of described first connector, and the cross-sectional area of described opening is less than the cross-sectional area in described connection chamber, described spring part is connected to described connection intracavity.
4. nucleic acid-extracting apparatus as claimed in claim 3, it is characterized in that: described second connector includes the connecting rod of the described limiting section of limiting section, magnetic part and connection and described magnetic part, described limiting section connects described connection intracavity, and the end of described limiting section abuts the free end of described spring part, described connecting rod mobile link is at described connection intracavity.
5. nucleic acid-extracting apparatus as claimed in claim 4, it is characterised in that: described second connector is work shape structure, and the cross-sectional area of described connecting rod is less than cross-sectional area and the cross-sectional area of described magnetic part of described limiting section.
6. the nucleic acid-extracting apparatus as described in claim 4 or 5, it is characterized in that: described thimble assembly includes mounting bar and the multiple adsorption tubes being vertically connected on described mounting bar, the opening of multiple described adsorption tubes is arranged on described mounting bar, described bar magnet assembly mobile link is in described adsorption tube, and single described magnetic part can move the bottom abutting to single described adsorption tube.
7. nucleic acid-extracting apparatus as claimed in claim 6, it is characterized in that: described nucleic acid-extracting apparatus also includes that moveable second supports seat, offering on described second support seat and be available for the mounting groove that described mounting bar is slidably installed, described mounting groove is upwards caved in by described support seat portion and is formed.
8. nucleic acid-extracting apparatus as claimed in claim 7, it is characterised in that: described second supports the opening one_to_one corresponding being further opened with being available on seat on multiple through holes that described bar magnet assembly passes, multiple described through holes and described mounting bar.
9. nucleic acid-extracting apparatus as claimed in claim 7 or 8, it is characterized in that: described first supports the first driving assembly being also associated with driving described first support seat to move up and down on seat, and described second supports the second driving assembly being also associated with driving described second support seat to move up and down on seat.
10. nucleic acid-extracting apparatus as claimed in claim 9, it is characterized in that: described nucleic acid-extracting apparatus also includes base, described splitter is positioned on described base, and described first supports seat is connected to the described second top supporting seat, and described second supports seat is positioned at the top of described splitter.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620244432.1U CN205653465U (en) | 2016-03-28 | 2016-03-28 | Nucleic acid extraction apparatus |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201620244432.1U CN205653465U (en) | 2016-03-28 | 2016-03-28 | Nucleic acid extraction apparatus |
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| Publication Number | Publication Date |
|---|---|
| CN205653465U true CN205653465U (en) | 2016-10-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201620244432.1U Active CN205653465U (en) | 2016-03-28 | 2016-03-28 | Nucleic acid extraction apparatus |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107779389A (en) * | 2017-12-04 | 2018-03-09 | 宁波东夏生物科技有限公司 | Nucleic acid extraction amplification device and its application method |
| CN110650804A (en) * | 2017-09-19 | 2020-01-03 | 瑞基海洋生物科技股份有限公司 | Biochemical reaction device and sleeve mechanism thereof |
| CN114933954A (en) * | 2022-07-25 | 2022-08-23 | 珠海宝锐生物科技有限公司 | Nucleic acid extraction device |
-
2016
- 2016-03-28 CN CN201620244432.1U patent/CN205653465U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110650804A (en) * | 2017-09-19 | 2020-01-03 | 瑞基海洋生物科技股份有限公司 | Biochemical reaction device and sleeve mechanism thereof |
| CN107779389A (en) * | 2017-12-04 | 2018-03-09 | 宁波东夏生物科技有限公司 | Nucleic acid extraction amplification device and its application method |
| CN107779389B (en) * | 2017-12-04 | 2024-02-06 | 浙江拓创医疗科技有限公司 | Nucleic acid extraction amplification device and method of use thereof |
| CN114933954A (en) * | 2022-07-25 | 2022-08-23 | 珠海宝锐生物科技有限公司 | Nucleic acid extraction device |
| CN114933954B (en) * | 2022-07-25 | 2022-11-11 | 珠海宝锐生物科技有限公司 | Nucleic acid extraction device |
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