CN205538979U - Multi -functional medical detector and multi -functional medical detecting system - Google Patents
Multi -functional medical detector and multi -functional medical detecting system Download PDFInfo
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- CN205538979U CN205538979U CN201620291969.3U CN201620291969U CN205538979U CN 205538979 U CN205538979 U CN 205538979U CN 201620291969 U CN201620291969 U CN 201620291969U CN 205538979 U CN205538979 U CN 205538979U
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Abstract
The utility model discloses a multi -functional medical detector includes application of sample mechanism, optical detection mechanism, reaction storehouse, actuating mechanism, electrode tip and testing result processing module, actuating mechanism has the drive output shaft, and the drive output shaft is located reaction storehouse middle part for the commentaries on classics of spiraling of reagent in the driving reaction storehouse, optical detection mechanism is located reaction storehouse below for follow the rotation of reagent dish, in proper order projection light in at least one dryness reagent piece that is used for biochemical detection on the reagent dish, and receive the warp the light of dryness reagent piece reflection obtains at least one biochemical reflection response magnitude of voltage that detects, the electrode tip is located the upper portion in reaction storehouse and has at least two electrodes contact of telescopic, and the electrode tip is used for following the rotation of reagent dish, loops through electrode on the electrode contact reagent dish to read the biochemical detection and/or the conventional voltage detection value of blood of sample. The utility model discloses still disclose a multi -functional medical detecting system.
Description
Technical field
This utility model relates to a kind of multifunctional medical detector and multifunctional medical detecting system.
Background technology
Body fluid or the medical detection means of blood to people, it is possible to for clinically to the diagnosis of disease, treatment with
And whether health status provides very favorable information foundation.Existing medical space such as hospital, clinic etc.,
Mensuration to projects such as clinical biochemistry, clinical immunology, hemocyte technology, blood group, blood clottings, due to
Each instrument can only use a kind of methodology detection, it is therefore desirable to is equipped with multiple instrument simultaneously and realizes detection, and
And, every kind of instrument volume is bigger, it is impossible to mobile, can only be completed in the laboratory of specialty by specialty detection teacher.
Utility model content
Technical problem to be solved in the utility model is to provide a kind of accuracy height, and reagent stability is good,
Simple in construction, compact, it is simple to the multifunctional medical detector carried and multifunctional medical detecting system thereof.
Technical problem of the present utility model is achieved through the following technical solutions:
As an aspect of the present utility model, it is provided that a kind of multifunctional medical detector, described multi-functional doctor
Treat detector and include sample charging mechanism, optical de-tection means, reaction warehouse, drive mechanism, electrode tip and detection knot
Really processing module；
Described reaction warehouse carries out biochemistry detection and/or the reagent disc of routine blood test detection, described reaction warehouse for placing
Bottom is provided with heater block；
Described drive mechanism has driving output shaft, and described driving output shaft is positioned in the middle part of described reaction warehouse, uses
Reagent disc in driving reaction warehouse rotates；
Described optical de-tection means is positioned at below described reaction warehouse, for following the rotation of reagent disc, throws successively
Penetrate at least one on described reagent disc of the light dryness analoids for biochemistry detection, and receive through institute
State the light of dryness analoids reflection, obtain the reflex response magnitude of voltage of at least one biochemistry detection；
Described sample charging mechanism is for being loaded for described reagent disc；
Described electrode tip is positioned at the top of reaction warehouse and has telescopic at least two electrode contacts, described electricity
Cartridge, for following the rotation of reagent disc, passes sequentially through the electrode on described electrode contacts contact reagent disc, with
Read biochemistry detection and/or the voltage detecting value of routine blood test of sample；
Testing result processing module, for the reflex response magnitude of voltage that obtains according to described optical de-tection means and
The voltage detecting value of described electrode tip, through being calculated the testing result of biochemistry detection and/or routine blood test.
In one embodiment, described optical de-tection means includes illuminating part, mirror lens, object lens, optical filtering
Wheel and daylighting portion；Position relationship between described illuminating part, mirror lens, object lens, filter wheel and daylighting portion
Meet: the light that illuminating part sends, after mirror lens reflects, projects on described dryness analoids, institute
The light stating the reflection of dryness analoids projects daylighting portion by described object lens and filter wheel；
Described daylighting portion is for converting optical signals into the reflex response magnitude of voltage of correspondence.
In one embodiment, described optical de-tection means also includes one of following plus lens or any group
Close: the first plus lens, the second plus lens and the 3rd plus lens；
Described first plus lens is between illuminating part and mirror lens；
Described second plus lens is between described mirror lens and reagent disc；
Described 3rd plus lens is between described filter wheel and daylighting portion.
In one embodiment, described daylighting portion includes: light cell and be connected with described light cell electric current/
Voltage transformation module.
In one embodiment, described illuminating part includes: constant current-supplying module, power output module, bulb,
Bulb internal resistance measurement feedback module；
Described constant current-supplying module, power output module and bulb are sequentially connected with；
Described bulb internal resistance measurement feedback module connects described bulb and described power output module；
Described power output module, for the size of the internal resistance according to described bulb, adjusts the input of described bulb
Voltage.
In one embodiment, described drive mechanism includes the driving motor being arranged on bottom reaction warehouse, described
The output shaft driving motor connects has external tooth gear, described external tooth gear to be placed in the middle part of reaction warehouse, is used for passing through
Described reagent disc is driven to rotate with the internal-gear engaged transmission in reagent disc；
Circumferentially arranged in described reaction warehouse have the spacing guide wheel of at least three, for limiting when reagent disc rotates
The position of pattern detection reagent disc.
In one embodiment, described drive mechanism includes the driving motor being arranged on bottom reaction warehouse, described
Rotate coaxially between reagent disc and the output shaft driving motor.
In one embodiment, described sample charging mechanism includes: drive mechanism and be connected with described drive mechanism
Feed head.
In one embodiment, described feed head includes: for pick up disposable tip syringe and with
Pressure transducer, controller and the sample-adding pump that described syringe connects；
Described pressure transducer is for detecting the air pressure in described syringe；
Described sample-adding pump provides power for syringe in time being loaded to reagent disc；
Described controller, for the air pressure detected according to described pressure transducer, enters with default voltage threshold
Row compares, and controls the air pressure in described syringe and reaches the air pressure needed for current injector duty；Described
Duty includes: suction status, shifting liquid status and sample-adding state.
Specifically, it may be that described controller is additionally operable to pick up disposable tip at the syringe of feed head
During, by the air pressure in described pressure transducer detection syringe, determine that disposable tip is the most damaged
Or blocking.
Specifically, it may be that described controller is additionally operable to pick up disposable tip at the syringe of feed head
During, by the change of the air pressure in described pressure transducer detection syringe, determine in sample and whether deposit
At bubble or grumeleuse.
In one embodiment, described drive mechanism includes: X-axis movement arm, Y-axis movement arm and Z axis fortune
Swing arm；X-axis, Y-axis and Z axis are the coordinate axes in rectangular coordinate system in space；
X-axis movement arm with Y-axis movement arm respectively two ends with Z axis movement arm be connected；
Motor, the screw mandrel connecting motor and the sliding shoe being enclosed within screw mandrel it is provided with on each movement arm,
Drive screw mandrel to rotate by motor, drive sliding shoe to slide；
Described feed head is fixed on that motion that position in X-axis movement arm and Y-axis movement arm is higher
On the sliding shoe of arm.
In one embodiment, the heater block of described reaction warehouse is to cover the heating film bottom reaction warehouse,
In described heating film enables to reaction warehouse, temperature stabilization controls at preset temperature.
In one embodiment, described multifunctional medical detector is additionally provided with waste holder, described waste holder top
Portion's opening, described opening part is provided with at least two panels shell fragment, makes for the disposable tip blocked on feed head
Feed head separates with described disposable tip.
In one embodiment, described multifunctional medical detector also includes suction nozzle box, puts in described suction nozzle box
It is equipped with disposable tip.
In one embodiment, described testing result processing module receives described by wired or wireless mode
Reflex response magnitude of voltage that optical de-tection means obtains and the voltage detecting value of described electrode tip.
As another aspect of the present utility model, it is provided that a kind of multifunctional medical detecting system, described many merits
Medical detection system can include the multifunctional medical detector described in any of the above-described item and be placed in described multi-functional
Reagent disc in medical detector, described reagent disc structure is circular, and described reagent disc is circumferentially arranged to be had
Some dryness analoidses and/or some routine blood test detection components, described routine blood test detection components include be loaded position,
It is provided with micro-pipe of micropore, controls the peristaltic pump that in micro-pipe, sample moves and the detection electricity being arranged on micropore
Pole.
In one embodiment, described reagent disc also includes an optical correction diffusive reflective plate.
The technical scheme that this utility model embodiment provides at least can realize following effect:
1, the multifunctional medical detector that this utility model embodiment provides is capable of multiple detection project and exists
Carry out on one equipment, and, use dryness reagent can no longer need when carrying out biochemistry detection with pure water, letter
Change the detection process of traditional detection instrument so that detector can be little while ensureing testing result accuracy
Type, it is simple to carry, it addition, the driving output shaft of drive mechanism is positioned in the middle part of described reaction warehouse drives reaction
The mode that reagent disc in storehouse rotates, relatively bel-drivenn mode, it is possible to so that the total of detector is enough
Compact, it is convenient for carrying, thus shortens the time expended from sampling, sample presentation and the whole process of detection, Ke Yishi
The times such as the other detection of the sick bed of clinical department now, family's general practitioner detect in patient home, emergency first-aid
Urgency requires higher occasion, is even applicable to pet clinic.
2, mode is directly driven in the reagent disc drive mechanism employing being arranged on reaction warehouse in this utility model embodiment,
Transmission efficiency is high, and reagent disc drive position is more accurate.
3, in reaction warehouse reagent disc rest area along the some spacing guide wheel that reagent disc cylindrical is circumferentially disposed, it is possible to
Effectively limit the position of reagent disc, it is ensured that reagent disc will not offset in reaction warehouse.
4, the illuminating part bulb of the optical de-tection means of this utility model embodiment uses constant current source power supply, logical
Crossing internal resistance measurement comparison circuit, that bulb internal resistance variable signal is sent to power output module in real time is amplified,
Change output voltage, so that bulb intensity is basically unchanged, add the service life of bulb.
5, the daylighting portion of the optical de-tection means of this utility model embodiment uses I/V low noise plus and blowup
Device, decreases the impact on signal of the amplifier self-noise, improves the signal to noise ratio of output signal, make output
Signal is more stable.
6, this utility model embodiment biochemistry detection reagent disc uses dryness reagent card to replace liquid reagent,
Article needed for total Test are included in a piece of dryness reagent, environmental protection and be prone to preserve and carry, and
Stabilization time is longer, and required specimen amount is less, meanwhile, remains again traditional biochemical reaction method, inspection
The chemical reaction surveyed is identical with the pattern of traditional biochemistry or principle, improves the traceability of system, it is ensured that inspection
Survey the accuracy of result.
7, in this utility model embodiment, biochemistry detection reagent disc uses dryness reagent card to replace liquid examination
Agent, need not be diluted sample, decrease measurement error, improves the accuracy in detection of instrument with accurate
Degree.
8, in this utility model embodiment, biochemistry detection reagent disc self provides reflecting background, it is not necessary to
Supporting cuvette and relevant apparatus, simplified the structure of detector.
9, using dryness analoids to replace liquid reagent in this utility model embodiment, instrument need not arrange liquid
Body reagent container, diluted sample device and water supply and sewage device so that instrument overall volume reduces, it is simple to carry.
10, the multifunctional medical detector of this utility model embodiment uses the reaction method of traditional detection, protects
The measurement result having demonstrate,proved apparatus measures result and existing detector has comparability.
Accompanying drawing explanation
Accompanying drawing 1: the multifunctional medical detector structural representation that this utility model embodiment provides；
Accompanying drawing 2: the multifunctional medical detector structure top view that this utility model embodiment provides；
Accompanying drawing 3: the multifunctional medical detector structural side view that this utility model embodiment provides；
Accompanying drawing 4: the multifunctional medical detector optical de-tection means schematic diagram that this utility model embodiment provides；
Accompanying drawing 5: the optical de-tection means illuminating part schematic diagram that this utility model embodiment provides；
Accompanying drawing 6: the optical de-tection means daylighting portion schematic diagram that this utility model embodiment provides；
Accompanying drawing 7: the sample charging mechanism schematic diagram that this utility model embodiment provides；
Accompanying drawing 8: the biochemistry detection reagent disc structural representation that this utility model embodiment provides；
Accompanying drawing 9: the ion detection reagent disc structural representation that this utility model embodiment provides；
Accompanying drawing 10: the routine blood test detectable dish structural representation that this utility model embodiment provides；
Accompanying drawing 11: the routine blood test another structural representation of detectable dish that this utility model embodiment provides；
Accompanying drawing 12: the master control borad of the multifunctional medical detector that this utility model embodiment provides is with each module even
Connect schematic diagram；
Accompanying drawing 13: this utility model embodiment provide multifunctional medical detector biochemistry detection specimen concentration with
Magnitude of voltage returns line diagram；
Accompanying drawing 14: certain laboratory medical equipment specimen concentration that this utility model embodiment provides is returned with magnitude of voltage
Return line diagram；
Accompanying drawing 15: multifunctional medical detector that this utility model embodiment provides and two medical detectors from
Son detection test specimen Concentration Testing Linear Comparison schematic diagram；
Accompanying drawing 16: the multifunctional medical detecting system schematic diagram that this utility model embodiment provides.
Detailed description of the invention
The utility model is described in further detail with specific embodiment below in conjunction with the accompanying drawings, so that the skill of this area
Art personnel can be better understood from this utility model and can be practiced, but illustrated embodiment is not as to this reality
With novel restriction.
As a specific embodiment of the present utility model, with reference to shown in Fig. 1-Fig. 3, multifunctional medical detects
Instrument, including sample charging mechanism 1, optical de-tection means 2, reaction warehouse 3, drive mechanism 4, electrode tip 5 and inspection
Survey result treatment module (not illustrating in figure)；
Described reaction warehouse 3 carries out biochemistry detection and/or the reagent disc 9 of routine blood test detection for placing, described instead
Answer and be provided with heater block bottom storehouse 3；
Described drive mechanism 4 has driving output shaft, and described driving output shaft is positioned in the middle part of described reaction warehouse 3,
Reagent disc in driving reaction warehouse 3 rotates；Drive mechanism 4 is set directly in the middle part of reaction warehouse 3,
Being suitable for use with directly driving the reagent disc controlled in reaction warehouse to rotate, transmission efficiency is high, relative to belt transmission, examination
Agent dish drive position is more accurate.
Described optical de-tection means 2 is positioned at below described reaction warehouse 3, for following the rotation of reagent disc, depends on
At least one on described reagent disc of secondary throw light is for the dryness analoids of biochemistry detection, and receives
Through the light of described dryness analoids reflection, obtain the reflex response magnitude of voltage of at least one biochemistry detection；
Described sample charging mechanism 1 is for being loaded for described reagent disc；
Described electrode tip 5 is positioned at the top of reaction warehouse 3 and has telescopic at least two electrode contacts, institute
State electrode tip 5 for following the rotation of reagent disc, pass sequentially through the electricity on described electrode contacts contact reagent disc
Pole, the voltage detecting value of biochemistry detection and/or routine blood test to read sample；Described electrode tip 5 can when working
To provide a predeterminated voltage, different size of normal voltage can be provided according to different detection projects simultaneously
Value, this standard voltage value can be 0 or other values.
Testing result processing module, for the reflex response magnitude of voltage that obtains according to described optical de-tection means and
The voltage detecting value of described electrode tip, through being calculated the testing result of biochemistry detection and/or routine blood test.
As a detailed description of the invention of the present utility model, shown in reference Fig. 4, described optical de-tection means
2 include illuminating part 201, mirror lens 202, object lens 203, filter wheel 204 and daylighting portion 205；Described
Position between illuminating part 201, mirror lens 202, object lens 203, filter wheel 204 and daylighting portion 205 is closed
System meets: the light that illuminating part 201 sends, after mirror lens 202 reflects, projects the examination of described dryness
On agent sheet, the light of described dryness analoids reflection is projected adopted by described object lens 203 and filter wheel 204
Light portion 205；
Described daylighting portion 205 is for converting optical signals into the reflex response magnitude of voltage of correspondence.
Specifically, it is also possible to be, described optical de-tection means 2 also includes one of following plus lens or any
Combination: the first plus lens the 206, second plus lens 207 and the 3rd plus lens 208；Described first
Plus lens 206 is between illuminating part 201 and mirror lens 202；Described second plus lens 207
Between described mirror lens 202 and reagent disc；Described 3rd plus lens 208 is positioned at described filter wheel 204
And between daylighting portion 205.The optical de-tection means 2 of multifunctional medical detector of the present utility model can be only
One or two kinds of in aforementioned three kinds of plus lens is set, it is also possible to is provided with the most above-mentioned three kinds and converges thoroughly
Mirror, can make suitably selection according to the position relationship of the space size of optical de-tection means 2 and each element.
More specifically, it may be that with reference to shown in Fig. 5, described illuminating part 201, including: constant current-supplying mould
Block, power output module, bulb, bulb internal resistance measurement feedback module；
Described constant current-supplying module, power output module and bulb are sequentially connected with；
Bulb internal resistance measurement feedback module connection bulb and power output module；
Power output module, for the size of the internal resistance according to described bulb, adjusts the input voltage of bulb.
More specifically, it may be that with reference to shown in Fig. 6, described daylighting portion 205, including: light cell and with
The current/voltage-converted module that described light cell connects.
As a specific embodiment in this utility model detailed description of the invention, with reference to shown in Fig. 4, luminous
Portion sends full wave light transmission the first plus lens 206, is irradiated to mirror lens 202, through reflection thoroughly
Mirror 202 filters useless infrared wavelength light, opens and is arranged on mirror lens 202 and the second plus lens 207
Between shutter 209, the light after reflection through second convergence saturating 207 mirrors, converge in particular agent dish
Specific region, through the light of reagent disc reflection, after eliminating veiling glare by object lens 203, through filter wheel 204
Obtain the reflection light of specific wavelength, finally through the 3rd plus lens 208, project light cell, light cell
Convert optical signals to voltage signal and export testing result processing module.Doing of different colours on reagent disc
The light that property analoids reflects, after eliminating veiling glare by object lens 203, is incident upon on light cell so that light
Magnitude of voltage is more accurate.
The bulb of the illuminating part 201 of the optical de-tection means 2 of this utility model embodiment uses constant-current source to supply
Electricity, is sent to power output module through putting by internal resistance measurement comparison circuit in real time by bulb internal resistance variable signal
After great, change output voltage, so that bulb intensity is basically unchanged, extend making of the bulb as consumptive material
Use the life-span.With reference to shown in Fig. 6, the current/voltage-converted module in the daylighting portion 205 of optical de-tection means 2 is adopted
With I/V (current/voltage) low noise high gain amplifier, low to light cell and I/V by constant current-supplying module
High gain amplifier of making an uproar is powered the impact decreasing amplifier self-noise to signal, improves signal output mould
The signal to noise ratio of block output signal, makes output signal more stable.By to illuminating part 201 and daylighting portion 205
Assembly optimization, it is achieved that stablizing of light path, the output signal obtained is more accurate.
With reference to shown in Fig. 1-3, described drive mechanism 4 includes the driving motor 401 being arranged on bottom reaction warehouse 3,
The output shaft of described driving motor connects has external tooth gear 402, described external tooth gear 402 to be placed in reaction warehouse 3
Middle part, referring again to shown in Fig. 8-Figure 10, reagent disc is circular, in being provided with on the inner periphery of reagent disc
Gear, the external tooth gear 402 on the output shaft of described driving motor 401 and the internal-gear on reagent disc
Engaged transmission drives reagent disc to rotate；
Specifically, it is also possible to be, with reference to shown in Fig. 1, circumferentially arranged in described reaction warehouse 3 have at least three
Individual spacing guide wheel 301, when reagent disc rotates under the drive driving motor 401, described at least three limits
Position guide wheel 301 limits the position of reagent disc, it is ensured that reagent disc will not offset in reaction warehouse.
As another specific embodiment of this utility model detailed description of the invention, described drive mechanism is all right
Following structure: this drive mechanism includes the driving motor being arranged on bottom reaction warehouse, described reagent disc with drive
Rotate coaxially between the output shaft of galvanic electricity machine.Such as, it is provided with at least one groove on annulus in described reagent disc
Mouthful, the output shaft driving motor is provided with equal number of key, when reagent disc is placed on corresponding to described groove
Time in reaction warehouse, the clamping corresponding with described key of described groove so that reagent disc drive under driven by motor with
Output shaft rotates coaxially.
As a specific embodiment of this utility model detailed description of the invention, with reference to shown in Fig. 1, described in add
Model machine structure 1 includes: drive mechanism 101 and the feed head 102 being connected with described drive mechanism 101.
Specifically, it may be that with reference to shown in Fig. 7, described feed head 102 includes: be used for picking up disposably
The syringe of suction nozzle 6 and the pressure transducer, sample-adding pump and the controller that are connected with described syringe；
Described pressure transducer is for detecting the air pressure in described syringe；
Described sample-adding pump provides power for syringe in time being loaded to reagent disc；
Described controller, for the air pressure detected according to described pressure transducer, enters with default voltage threshold
Row compares, and controls the air pressure in described syringe and reaches the air pressure needed for current injector duty；Described
Duty includes: suction status, shifting liquid status and sample-adding state.
More specifically, it may be that described controller is additionally operable to pick up disposable at the syringe of feed head 102
During suction nozzle 6, by the air pressure in described pressure transducer detection syringe, determine that disposable tip is
No breakage or blocking.
More specifically, it may be that described controller is additionally operable to pick up disposable at the syringe of feed head 102
During suction nozzle 6, by the change of the air pressure in described pressure transducer detection syringe, determine in sample
Whether there is bubble or grumeleuse.
Specifically, it may be that with reference to shown in Fig. 1, described drive mechanism 101 includes: X-axis movement arm,
Y-axis movement arm and Z axis movement arm；X-axis, Y-axis and Z axis are the coordinate axes in rectangular coordinate system in space；
X-axis movement arm with Y-axis movement arm respectively two ends with Z axis movement arm be connected；
Motor, the screw mandrel connecting motor and the sliding shoe being enclosed within screw mandrel it is provided with on each movement arm,
Drive screw mandrel to rotate by motor, drive sliding shoe to slide；
Feed head is fixed on that movement arm that in X-axis movement arm and Y-axis movement arm, position is higher
On sliding shoe.
The drive mechanism of the present embodiment is linked by the cooperation of three-axis moving arm, is moved extremely accurately by feed head
Precalculated position.The drive mechanism of the feed head of this utility model embodiment is not limited in present embodiment
Drive mechanism, is capable of adding in any space that can be limited when this multifunctional medical detector is loaded
Sample head is that the drive mechanism of reagent disc sample-adding is all applicable to this utility model.
As a specific embodiment of detailed description of the invention of the present utility model, with reference to shown in Fig. 1, described
The heater block of reaction warehouse 3 can be such as to cover the heating film bottom reaction warehouse 3, and described heating film sets
Put the back side at reaction warehouse 3 base, described heating film, have employed PID (PID) regulation,
So that temperature stabilization controls at preset temperature in reaction warehouse 3.
As a specific embodiment of detailed description of the invention of the present utility model, with reference to shown in Fig. 1, described
Multifunctional medical detector is additionally provided with waste holder 8, the open top of described waste holder 8, and described opening part sets
There is at least two panels shell fragment, make feed head 102 and institute for blocking the disposable tip 6 on feed head 102
State disposable tip 6 to separate.
As a specific embodiment of detailed description of the invention of the present utility model, described multifunctional medical detects
Instrument also includes suction nozzle box 7, is placed with disposable tip 6 in described suction nozzle box 7.
As a specific embodiment of detailed description of the invention of the present utility model, described testing result processes mould
Block receives, by wired or wireless mode, reflex response magnitude of voltage and the institute that described optical de-tection means obtains
State the voltage detecting value of electrode tip.
As a specific embodiment of detailed description of the invention of the present utility model, multifunctional medical detector is also
Including bar code scan instrument, Quick Response Code can be set on reagent disc, come by the Quick Response Code on scanning reagent disc
Determine composition lot number and the effect duration of reagent disc.
As a specific embodiment of detailed description of the invention of the present utility model, multifunctional medical detector is also
Including a master control borad, with reference to shown in Figure 12, described master control borad is examined with the sample charging mechanism of detector, optics
Survey and between the modules such as mechanism, electrode tip, power supply, use controller local area network (Controller Area
Network, CAN) bus mode communicates.Display screen and button can be set on master control borad, pass through
Operation master control borad controls each module work of detector, and the testing result of detector feeds back to detection knot
Really processing module (such as notebook computer, panel computer or other there is the terminal etc. of computing function),
Testing result processing module is by the way of wired or wireless (such as bluetooth, WiFi, 3G etc.) and master
Control plate communicates.
What this utility model embodiment provided can carry out the biochemical and multifunctional medical detection of routine blood test detection
Instrument, volume is little, integration degree is high, portable, easy and simple to handle.Separately below by 3 different enforcements
Example illustrates.
This utility model embodiment 1:
The present embodiment illustrates by as a example by biochemistry detecting item:
With reference to shown in Fig. 8, reagent disc is circular, is provided above with multiple biochemical reagents sheet 901 (multiple
Biochemical reagents sheet includes uric acid biochemical reagents sheet) and diffusive reflective plate 903, permissible at the middle part of reagent disc
It is provided with internal-gear, before on-test, takes out reagent disc, after placement appropriate time returns to room temperature, will examination
Agent dish is placed in the reaction warehouse 3 of above-mentioned multifunctional medical detector, at the driving machine of multifunctional medical detector
Structure 4 output shaft is provided with bites the external tooth gear 402 of conjunction mutually with described internal-gear, is provided with in reaction warehouse 3
Three spacing guide wheels 301, for limiting the position of reagent disc.
Take detection sample and be placed in sample position, complete reagent disc by sample charging mechanism and be loaded.The sample-adding when sample-adding
The drive mechanism 101 of mechanism 1 is driven by the motor on X-axis movement arm, Y-axis movement arm and Z axis movement arm
Movable wire bar drives sliding shoe to slide, thus drives feed head to run to precalculated position.
When sample-adding work starts, first drive mechanism 101 drives feed head to the suction nozzle box of disposable tip 6
Above in the of 7, the syringe of feed head 102 pick up disposable tip 6, in pickup disposable tip 6 process
In, the pressure transducer of feed head 102 judges one according to the change of the atmospheric pressure in the syringe detected
Whether secondary property suction nozzle 6 exists the problems such as obstruction and gas leakage, pinpoints the problems and can report to the police.
Feed head 102 after pickup disposable tip 6 moves to draw at specimen specimen, draws the mistake of specimen
Cheng Zhong, feed head 102 can be according to whether there is bubble in the change-detection specimen of pressure, and grumeleuse etc. affects inspection
The material surveyed.
After absorption sample completes, feed head 102, under the drive of drive mechanism 101, moves to be loaded position etc.
Waiting to be loaded, in pipetting processes, the pressure transducer continuous firing of feed head 102, in detection syringe
Pressure, as pressure occurs more than the fluctuation of predetermined threshold, stops moving liquid, and reports to the police.Feed head 102 meeting exists
Filling sample by sample-adding pump on reagent disc each dry tablet hole, often complete once to be loaded, reagent disc can drive
Rotate to next dry tablet position under the drive of mechanism, be again loaded.Pressure is had equally during sample-adding
Power detects, the problems such as it is abnormal whether perception exists sample size, bubble, pinpoints the problems and can stop sample-adding, and
Report to the police.
With reference to shown in Fig. 7, in feed head 102 work process, air pressure signal can be turned by pressure transducer
Being changed to voltage signal output, simulation, after signal conditioning circuit, is believed by voltage signal by D/A conversion unit
Number be converted to digital signal, become the magnitude of voltage that controller can read.Controller reads this voltage letter in real time
Number, by comparing with the threshold value being previously set, control the air pressure in described syringe and reach currently to note
Air pressure needed for emitter duty；Owing to equipment is during drawing sample and dropping sample, inject storehouse
Interior atmospheric pressure is different, so by the air pressure level in monitoring syringe in real time, by sample-adding
The work of pump, controls syringe precise operation under suction status, shifting liquid status and sample-adding state.
After sample-adding work completes, reagent disc passes through to cover the heating film work bottom reaction warehouse 3 in reaction warehouse
In making to control reaction warehouse 3, temperature stabilization is hatched at preset temperature.Described preset temperature is 37 ± 0.1 DEG C
Temperature, simulation normal person's body temperature is hatched, and allows required biochemical reaction carry out, and incubation time regards concrete
Project and different, such as uric acid project incubation time is 5 minutes.
After in reagent disc, sample incubation completes, each dryness analoids 901 of reagent disc is carried out by detector respectively
Optical detection.
As a example by uric acid dryness analoids, when optical detection starts, the bulb of illuminating part 201 sends all-wave
Light transmission first plus lens 206 of section, filters useless infrared wavelength light through mirror lens 202, instead
Through the second plus lens 207 after penetrating, converging on the uric acid dryness analoids 901 of reagent disc, uric acid is done
The light that property analoids 901 reflects obtains the reflection light of specific wavelength, this reflection light transmission through filter wheel
Daylighting portion 205, daylighting portion 205 is projected after object lens 203, filter wheel 204 and the 3rd plus lens 208
Light intensity signal being converted into voltage signal and is delivered to master control borad, the reflection light of varying strength is radiated at light cell
On, different size of voltage can be produced.This voltage, will by D/A conversion unit after signal conditioning circuit
Analogue signal is converted to digital signal, becomes the signal that master control borad can read.The signal that master control borad will read
Being sent to testing result processing module by wired or wireless mode, testing result processing module main frame passes through one
After serial analysis, draw the concentration of this biochemical indicator.
Detection test completes, and feed head 102 can move to, above waste holder 8, feed head 102 be probeed into examination
Agent box 8 open top, is provided with at least two panels shell fragment at opening part, for blocking the disposable suction on feed head
6, when feed head 102 is during opening part moves up, feed head 102 will with described disposably
Suction nozzle 6 separates.Experimenter opens hatch door, manually takes out used reagent disc, puts into special the moulding of garbage
In pocket.
For ensureing that detector analysis result is accurate, before detection on-test, it is possible to use overflowing on reagent disc
Reflector plate 903 carries out optical correction to the dry tablet on reagent disc, all band light warp respectively sent by bulb
Intensity of illumination when diffusive reflective plate 903 reflexes to daylighting portion 205 with dryness analoids 901 is different, calculates two
Person's light intensity difference, the light intensity value obtained in pattern detection is tested, plus this difference, is dryness analoids 901
The actual light intensity values of reflection light.
Above-mentioned uric acid dryness analoids in the present embodiment, includes the most successively: dispersion layer, reflecting layer,
Connecting layer, reagent layer and support layer；Wherein: described support layer is optical clear base material；Described reagent layer master
Will be by uricase, peroxidase, 2-(3,5-dimethoxy-4 '-hydroxyphenyl)-4,5-to (4-dimethyl amine
Base phenyl) imidazoles, surfactant and fixative constitute；Described connecting layer is mainly by the dilute acyl of poly-N-isopropyl
Amine is constituted；Described reflecting layer is mainly made up of white reflector material；Described dispersion layer is mainly by the porous bonded
Microgranule and surfactant are constituted.
Further, mentioned reagent layer includes: uricase, peroxidase, 2-(3,5-dimethoxy-4 's-
Hydroxyphenyl)-4,5-is to (4-dimethyl amido phenyl) imidazoles, surfactant and fixative；
Above-mentioned connecting layer is the dilute amide of poly-N-isopropyl；
Above-mentioned reflecting layer is white reflector material；
Above-mentioned dispersion layer is small porous particle and the surfactant of bonding.
The Cleaning Principle of uric acid dryness analoids is: when sample drop to be detected is on uric acid dryness analoids
Time, it being uniformly distributed in next layer by diffusion layer, the uric acid in sample moves to reagent layer, at uricase
Effect under, be oxidized to form allantoin and hydrogen peroxide, then, hydrogen peroxide is under peroxidase effect
Aoxidize colourless stain, generate colored dyes, by the reflective light intensity of colored dyes is detected, finally may be used
To analyze uric acid biochemistry concentration.
Reagent layer reaction principle is as follows:
Above-mentioned diffusion layer Main Function be formed molecular sieve, allow sample be uniformly distributed under gravity and under
Ooze, be also filtered at this layer testing unrelated chaff interference.
Mentioned reagent layer contains multiple dryness powder reagent, owing to sample is affected by what gravity moved downward, and examination
The structure of oxidant layer can efficiently control course of reaction.Reagent layer contains dryness dyestuff, detects the most final
There is color change, and be fixed on this layer, in order to detection light path detection.
Above-mentioned connecting layer is the material of layer of gel class, and its effect is to stop reacted color layer reagent to it
His layer spreads.
Above-mentioned support layer is one layer of optical clear base material, it is allowed to the light of detection passes through, and it is above-mentioned to play support
The effect of each layer.Optical clear base material can be such as glass, polyethylene, polypropylene, polrvinyl chloride or
Polyester.
In one embodiment, in reagent layer, the content of each component can have multiple, the most following several:
Uricase 0.022U/cm2, peroxidase 0.4U/cm2, 2-(3,5-dimethoxy-4 '-hydroxyphenyl)-4,5-
To (4-dimethyl amido phenyl) imidazoles 2cm2, surfactant 3.2mg/cm2With fixative 2.4mg/cm2。
Uricase 0.018U/cm2, peroxidase 0.8U/cm2, 2-(3,5-dimethoxy-4 '-hydroxyphenyl)-4,5-
To (4-dimethyl amido phenyl) imidazoles 1cm2, surfactant 4.2mg/cm2With fixative 1.9mg/cm2。
Uricase 0.022U/cm2, peroxidase 0.8U/cm2, 2-(3,5-dimethoxy-4 '-hydroxyphenyl)-4,5-
To (4-dimethyl amido phenyl) imidazoles 2cm2, surfactant 4.2mg/cm2With fixative 2.4mg/cm2。
Uricase 0.018U/cm2, peroxidase 0.4U/cm2, 2-(3,5-dimethoxy-4 '-hydroxyphenyl)-4,5-
To (4-dimethyl amido phenyl) imidazoles 1cm2, surfactant 3.2mg/cm2With fixative 1.9mg/cm2。
Uricase 0.02U/cm2, peroxidase 0.6U/cm2, 2-(3,5-dimethoxy-4 '-hydroxyphenyl)-4,5-
To (4-dimethyl amido phenyl) imidazoles 1.4cm2, surfactant 3.9mg/cm2With fixative 2.17mg/cm2。
In mentioned reagent layer, the content of each component is not limited to above-mentioned example, is more than example.
In one embodiment, above-mentioned fixative includes: gelatin, hydrophilic cellulose derivatives, glucosan,
Any one in agarose, polyvinyl alcohol and polyacrylamide or above-mentioned any multiple combination.
Surfactant can play the effect such as moistening, emulsifying, dispersion in reagent layer, promote sample fully,
Quickly and reacting substance generation chemical reaction.
Above-mentioned 2-(3,5-dimethoxy-4 '-hydroxyphenyl)-4,5-is nothing to (4-dimethyl amido phenyl) imidazoles
Color stain.
In one embodiment, in connecting layer, the content of the dilute amide of poly-N-isopropyl is 2～5mg/cm2.Preferably
Ground, the content of the dilute amide of above-mentioned poly-N-isopropyl is 3mg/cm2。
In one embodiment, reflecting layer can be any there is high reflectance (such as reflection coefficient exists
More than 95%) whiteness, above-mentioned white reflector material includes: titanium dioxide, barium sulfate or the two
Mixture, the thickness in reflecting layer is 10～500 μm.It is preferred that the thickness in above-mentioned reflecting layer is 50～300
μm。
In one embodiment, the small porous particle in dispersion layer is titanium dioxide, barium sulfate, zinc oxide, oxygen
Change lead, kieselguhr, microcrystalline Cellulose or the microgranule of the most any several mixture.
The various microgranules of dispersion layer can be added surfactant and be bonded, such as by the bonding agent of appropriate amount
Employing acetate fiber bonds.
A diameter of 1-7 μm of the microgranule of dispersion layer, thickness 30～500 μm of described dispersion layer, porosity
25%～95%.
When small porous particle is titanium dioxide, the mass ratio of titanium dioxide and surfactant is: 200:1～30:1.
Preserving for convenience, transport, above-mentioned uric acid dryness analoids can also include: upper housing and lower housing,
Upper housing is positioned on dispersion layer, and lower housing is positioned under support layer, and bonding between upper housing and lower housing.
Uric acid dryness analoids is fixedly installed on reagent disc, is loaded uric acid dryness analoids, then
Incubation time about 5 minutes at 37 DEG C, then the optical detection portion in the lower section of reagent disc can be in test requirements document
Time respective wavelength filter (such as uric acid project is the filter of wavelength 670nm) to uric acid in reagent disc
The color of dryness analoids color layer carries out interpretation (reading intensity of reflected light), carry out once during interpretation or
Repeatedly reading, uric acid project is end-point method, finally gives intensity of reflected light.Through dividing after obtaining intensity of reflected light
Analysis obtains reflex response magnitude of voltage, is finally calculated uric acid testing result value through detector.
Need uric acid project detection project is calibrated before.
Calibration process is as follows:
On equipment, calibration is completed with the calibration solution of concentration known.Calibration solution comprises 3-5 water of test substance
Flat concentration, reads corresponding intensity of reflected light on equipment respectively, and each level reads and is averaged for 3-5 time
Value.
In URIC uric acid project, testing result computing formula is:
N (detector magnitude of voltage)=K*ln (specimen concentration)+b
Wherein, K is calibration curve slope, and b is the intercept of calibration curve
Return line chart according to specimen concentration and detector magnitude of voltage and obtain the calibration data in following table, carry out as follows
Calculate:
| Specimen concentration | Detector magnitude of voltage | Ln (specimen concentration) | Ln (detector magnitude of voltage) |
| 29.7 | 2.2056 | 3.391147046 | 0.790999581 |
| 223 | 2.1049 | 5.407171771 | 0.74426796 |
| 338.9 | 2.0756 | 5.825705079 | 0.730250269 |
| 595 | 2.0459 | 6.388561406 | 0.71583779 |
| 959.9 | 2.0234 | 6.866829112 | 0.704779265 |
0.79=3.68k+b
0.73=5.83k+b
0.70=6.86k+b
Obtain K=-0.0279 b=0.8927
The calibration curve i.e. obtaining this this batch of project is ln (magnitude of voltage)=-0.0279*ln (specimen concentration)
+0.8927
After calibrating successfully, the photovoltage value obtained according to concrete test specimen, bring in above-mentioned calibration curve
Computing, just can get the concentration value of specimen.
Such as obtain lnr=0.7241 when photovoltage value r=2.0628 measured, bring in formula and obtain:
Ln (specimen concentration)=(0.7241-0.8927)/(-0.0279)
It is computed showing that specimen concentration value is 422mmol/l.
Detector of the present utility model is detected equipment comparing result with certain large-scale experiment room existing, with reference to Figure 13
It show the result that several concentration known titers are measured by two instruments respectively, from above two figures with Figure 14
Table is it can be seen that the result of detector of the present utility model is linear and the detection the most basic of contrast instrument
Cause, it is ensured that the accuracy of testing result.
This utility model embodiment 2:
The present embodiment is by illustrating as a example by the ion detection project in biochemistry detecting item:
With reference to shown in Fig. 9, ion detection project can use the reagent comprised for ion detection parts
Dish, this reagent disc is circular, comprises some dryness analoidses 901 with multilayer film in each reagent disc
(being used for different kinds of ions detection project), each dryness analoids 901 is provided with pair of electrodes 904.
Internal-gear can be provided with at the middle part of reagent disc, before on-test, take out ion detection project reagent disc,
After placement appropriate time returns to room temperature, by reagent disc load facility reaction warehouse 3.
As a example by potassium ion detection project, take detection blood sample, put into specimen position.By sample charging mechanism 102
Pickup disposable tip 6, picks up sample, completes each analoids sample-adding in sample-adding position.Potassium in the present embodiment
In ion detection project, feed head 102 picks up disposable tip 6 and sample, to reagent disc sample-adding process with
Process in embodiment 1 is consistent, does not repeats them here.
After completing sample-adding, reagent disc can keep temperature simulation normal person's body temperature of 37 ± 0.1 DEG C in reaction warehouse
Hatching, ion detection project incubation time is about 3 minutes.
After having hatched, the electrode on the electrode contacts contact reagent disc dryness analoids of electrode tip, reads examination
The voltage detecting value (the response electromotive force of dryness analoids) of sample on agent dish, it should be noted that at ion
In detection project, electrode tip self does not provide the standard voltage value of voltage, i.e. electrode tip to be 0.Electrode tip will be read
The voltage detecting result got, is delivered to master control borad, and the signal read is passed through wired or wireless side by master control borad
Formula is sent to testing result processing module, and testing result processing module is according to this response electromotive force and predefines
The characteristic curve (reflection potassium concentration and the curve of relation responding electromotive force) of this dryness analoids draw
Potassium ion detection range estimation test result.
Detection test completes, and feed head 102 can move to, above waste holder 8, feed head 102 be probeed into examination
Agent box 8 open top, is provided with at least two panels shell fragment at opening part, for blocking the disposable suction on feed head
6, when feed head 102 is during opening part moves up, feed head 102 will with described disposably
Suction nozzle 6 separates.Experimenter opens hatch door, manually takes out used reagent disc, puts into special the moulding of garbage
In pocket.
Shown in Figure 15 be this utility model embodiment provide multifunctional medical detector respectively with existing certain
Large-scale experiment room detection equipment (be designated yiyong1 and be designated yiyong2) carries out ion detection item visual inspection
Surveying comparative test result, in figure, the lines comprising square are the result of the tests of the equipment being designated yiyong1,
The lines comprising circle are the result of the tests of the equipment being designated yiyong2, and the lines comprising triangle are to adopt
By the result of the test of the multifunctional medical detector that the embodiment of the present invention provides；In loga, a is known sample
Concentration, loga is exactly the logarithm value of concentration of specimens, from above chart it can be seen that detection of the present utility model
The result of instrument is linearly the most basically identical with the detection of contrast instrument.
Potassium ion dryness analoids used in the present embodiment, such as, can include that substrate, potassium ion select
Electrode, salt bridge and insulating barrier.Potassium ion-selective electrode includes: contact electrode, reaction electrode, solid state electrolysis
Matter reference layer, potassium ion selective membrane.
In the present embodiment, the preparation process of potassium ion dryness analoids comprises the steps:
1, starch at its surface printing silver with silk-screen printing technique in polyethylene terephthalate, preparation
Contact electrode.Printing equipment half tone is 200 mesh, print thickness 200 μm, and condition of cure is: 150 DEG C,
30min。
2, chemical method is used to aoxidize by front for dried contact electrode 2/3 section.Concrete oxidation step: will
Needing the contact electrode aoxidizing position to be immersed in 0.1mol/L ferric chloride solution after 60s, taking-up pure water is clear
Wash clean is also dried, and has both obtained reaction electrode.
3, electrolyte reference layer coating.By 6g polyvinyl alcohol, 1g glycerol, 3g sodium chloride, 1g potassium chloride,
0.02g antibacterial, 0.004g surfactant H212 is dissolved in 50g water, is coated with automatic coating machine
It is distributed on reaction electrode, coating thickness 200 μm, coating speed 50mm/s, reference after reaction electrode coating
It is positioned over 21 DEG C after Ceng, is dried 60min under relative humidity 50% environment.
4, potassium ion selective membrane coating.By 0.1g hydroxyvinyl resin, 0.1g ortho-nitrophenyl octyl ether, 0.005g
Double [(benzene-15-crown ether-4)-4 '-methyl] pimelate, 0.002g sodium tetraphenylborate, 0.005g surfactant H212
It is dissolved in acetone, is coated on solid electrolyte reference layer with automatic coating machine, coating thickness 100
μm, coating speed 50mm/s, and drying at room temperature.
5, after potassium ion selective membrane has been dried, prepared by potassium ion-selective electrode, takes the choosing of two panels potassium ion
(salt bridge is sealed among insulating barrier, for making ginseng by osmosis with insulating barrier and salt bridge respectively to select electrode
Contact with each other than liquid and test fluid, make the connection of two potassium ion-selective electrodes, form loop) on hole site
Align and use 705 silicone rubber bonding.
6, after adhesive solidification, substrate edges is bonding with insulating barrier edge 705 silicone rubber, and adhesive is solid
After change prepared by potassium ion biochemical analysis dry tablet.
This utility model embodiment 3:
The present embodiment illustrates by as a example by routine blood test project:
With reference to shown in Figure 10 and Figure 11, can use in routine blood test project and there is routine blood test detection function
Reagent disc, this reagent disc is circular, the routine blood test detection components 902 of reagent disc comprise many group sample-adding positions,
Be provided with micropore micro-pipe, control peristaltic pump that in micro-pipe, sample moves, the detecting electrode that is arranged on micropore with
And waste collecting device, in Figure 11, arrow show sample moving direction in micro-pipe.Described reagent disc
Middle part can be provided with internal-gear, before on-test, take out routine blood test detection project reagent disc, place suitable
After the time returns to room temperature, by reagent disc load facility reaction warehouse.
Take detection blood sample, put into specimen position.Disposable tip 6 is picked up, pickup by sample charging mechanism 102
Sample, completes each analoids sample-adding in sample-adding position.Feed head 102 in the present embodiment intermediate ion detection project
Pickup disposable tip 6 and sample, consistent with the process in embodiment 1 to the process of reagent disc sample-adding,
This repeats no more.
After completing sample-adding, diluent (normal saline) is had to be diluted mixing to sample in reagent disc sample-adding position
Even, reagent disc can keep temperature simulation normal person's body temperature of 37 ± 0.1 DEG C to hatch in reaction warehouse, from
Sub-detection project incubation time is about 5 minutes.
With reference to shown in Figure 11, in the present embodiment, routine blood test detection uses the high frequency method of sampling, its
Principle application is Coulter principle.Molecule i.e. hemocyte passes through small in the medium of conductor solution
Hole, the when of adding constant-current source in both sides, hole, can produce the minor variations of voltage, and this change is with molecule
The i.e. diameter of hemocyte is relevant.The aperture of diameter 2-5 micron is there is, by compacted in the reagent disc of cytometry
Hemocyte after the pressure that dynamic pump produces makes mixed diluting passes sequentially through, and can produce electricity when cell is by sensor
Pulse, this signal of telecommunication is by, after high speed signal modulate circuit, being turned analogue signal by high-speed digital-analog converting unit
It is changed to digital signal, becomes the magnitude of voltage that controller can read.Owing to cell quantity is very big, corresponding arteries and veins
Rushing very high frequency, the requirement for integrated circuit is higher.Master control borad will collect magnitude of voltage and upload to detection knot
Really processing module, after testing result processing module is by a series of analyses, it can be deduced that various types of cells in blood
Count value.
After detection on-test, the sample after dilution passes through micro-along fine duct under reagent disc peristaltic pump drives
Hole, now the electrode contacts contact of electrode tip detecting electrode on micropore, electrode tip applies a normal voltage,
Different hemocytees can cause different potential pulses to change through micropore, by measuring and analyzing these arteries and veins
Punching change and number of times, can obtain routine blood test project in blood of human body needs each numerical value of detection, sample warp
Waste collecting device is finally flowed into after crossing micropore.
This utility model also provides for a kind of multifunctional medical detecting system, shown in reference Figure 16, and described many merits
Medical detection system can include above-mentioned multifunctional medical detector and be placed in described multifunctional medical detector
Reagent disc 9, described reagent disc 9 structure is circular, described reagent disc 9 is circumferentially arranged have some dry
Property analoids 901 and/or some routine blood test detection components 902, described routine blood test detection components 902 includes adding
Sample position, it is provided with micro-pipe of micropore, controls the peristaltic pump that in micro-pipe, sample moves and the inspection being arranged on micropore
Survey electrode.
Further, described reagent disc 9 also includes an optical correction diffusive reflective plate 903 and/or some electricity
Pole 904.
Multifunctional medical detector in the multifunctional medical detecting system that this utility model embodiment provides
Detailed description of the invention, can refer to the multifunctional medical detector described in previous embodiment, no longer enters at this
Row repeats.
Embodiment described above is only the preferred embodiment lifted by absolutely proving this utility model, this reality
It is not limited to this with novel protection domain.Those skilled in the art are made on the basis of this utility model
Equivalent substitute or conversion, all within protection domain of the present utility model.Protection domain of the present utility model
It is as the criterion with claims.
Claims (18)
1. a multifunctional medical detector, it is characterised in that described multifunctional medical detector includes adding
Model machine structure (1), optical de-tection means (2), reaction warehouse (3), drive mechanism (4), electrode tip (5)
With testing result processing module；
Described reaction warehouse (3) carries out biochemistry detection and/or the reagent disc (9) of routine blood test detection for placing,
Described reaction warehouse (3) bottom is provided with heater block；
Described drive mechanism (4) has driving output shaft, and described driving output shaft is positioned at described reaction warehouse (3)
Middle part, is used for driving the reagent disc in reaction warehouse (3) to rotate；
Described optical de-tection means (2) is positioned at described reaction warehouse (3) lower section, for following the rotation of reagent disc
Turning, at least one on described reagent disc of throw light is for the dryness analoids of biochemistry detection successively,
And receive the light through the reflection of described dryness analoids, obtain the reflex response electricity of at least one biochemistry detection
Pressure value；
Described sample charging mechanism (1) is for being loaded for described reagent disc；
Described electrode tip (5) be positioned at reaction warehouse (3) top and have telescopic at least two electrode touch
Point, described electrode tip (5), for following the rotation of reagent disc, passes sequentially through the contact examination of described electrode contacts
Electrode (904) on agent dish, the voltage detecting value of biochemistry detection and/or routine blood test to read sample；
Testing result processing module, for the reflex response magnitude of voltage that obtains according to described optical de-tection means and
The voltage detecting value of described electrode tip, through being calculated the testing result of biochemistry detection and/or routine blood test.
2. multifunctional medical detector as claimed in claim 1, it is characterised in that described optical detection
Mechanism includes illuminating part (201), mirror lens (202), object lens (203), filter wheel (204) and adopts
Light portion (205)；Described illuminating part (201), mirror lens (202), object lens (203), filter wheel (204)
With the position relationship between daylighting portion (205) meets: the light that illuminating part (201) sends is through reflection thoroughly
After mirror (202) reflection, projecting on described dryness analoids, the light of described dryness analoids reflection leads to
Cross described object lens (203) and filter wheel (204) projects daylighting portion (205)；
Described daylighting portion (205) is for converting optical signals into the reflex response magnitude of voltage of correspondence.
3. multifunctional medical detector as claimed in claim 2, it is characterised in that described optical detection
Mechanism (2) also includes one of following plus lens or combination in any: the first plus lens (206), second
Plus lens (207) and the 3rd plus lens (208)；
Described first plus lens (206) is positioned between illuminating part (201) and mirror lens (202)；
Described second plus lens (207) is positioned between described mirror lens (202) and reagent disc；
Described 3rd plus lens (208) is positioned between described filter wheel (204) and daylighting portion (205).
4. multifunctional medical detector as claimed in claim 2 or claim 3, it is characterised in that described daylighting
Portion (205), including: light cell and the current/voltage-converted module being connected with described light cell.
5. multifunctional medical detector as claimed in claim 2 or claim 3, it is characterised in that described luminescence
Portion (201), including: constant current-supplying module, power output module, bulb, bulb internal resistance measurement feedback mould
Block；
Described constant current-supplying module, power output module and bulb are sequentially connected with；
Described bulb internal resistance measurement feedback module connects described bulb and described power output module；
Described power output module, for the size of the internal resistance according to described bulb, adjusts the input of described bulb
Voltage.
6. multifunctional medical detector as claimed in claim 1, it is characterised in that described drive mechanism
(4) the driving motor (401) being arranged on reaction warehouse (3) bottom, described driving motor (401) are included
Output shaft connect have external tooth gear (402), described external tooth gear (402) be placed in reaction warehouse (3) middle part,
For by driving described reagent disc to rotate with the internal-gear engaged transmission in reagent disc；
Circumferentially arranged in described reaction warehouse (3) have the spacing guide wheel of at least three (301), at reagent
The disc spins time limit determines the position of pattern detection reagent disc.
7. multifunctional medical detector as claimed in claim 1, it is characterised in that described drive mechanism
(4) the driving motor (401) being arranged on reaction warehouse (3) bottom, described reagent disc and driving motor are included
(401) rotate coaxially between output shaft.
8. multifunctional medical detector as claimed in claim 1, it is characterised in that described sample charging mechanism
(1) including: drive mechanism (101) and the feed head (102) being connected with described drive mechanism (101).
9. multifunctional medical detector as claimed in claim 8, it is characterised in that feed head (102)
Including: it is used for the pressure sensing picking up the syringe of disposable tip (6) and being connected with described syringe
Device, controller and sample-adding pump；
Described pressure transducer is for detecting the air pressure in described syringe；
Described sample-adding pump provides power for syringe in time being loaded to reagent disc (9)；
Described controller, for the air pressure detected according to described pressure transducer, enters with default voltage threshold
Row compares, and controls the air pressure in described syringe and reaches the air pressure needed for current injector duty；Described
Duty includes: suction status, shifting liquid status and sample-adding state.
10. multifunctional medical detector as claimed in claim 9, it is characterised in that described controller is also
During picking up disposable tip (6) at the syringe of feed head (102), passed by described pressure
Air pressure in sensor detection syringe, determines that disposable tip (6) is the most damaged or blocks.
11. multifunctional medical detectors as claimed in claim 9, it is characterised in that described controller is also
During picking up disposable tip (6) at the syringe of feed head (102), passed by described pressure
The change of the air pressure in sensor detection syringe, determines and whether there is bubble or grumeleuse in sample.
12. multifunctional medical detectors as claimed in claim 8, it is characterised in that described drive mechanism
(101) including: X-axis movement arm, Y-axis movement arm and Z axis movement arm；X-axis, Y-axis and Z axis are
Coordinate axes in rectangular coordinate system in space；
X-axis movement arm with Y-axis movement arm respectively two ends with Z axis movement arm be connected；
Motor, the screw mandrel connecting motor and the sliding shoe being enclosed within screw mandrel it is provided with on each movement arm,
Drive screw mandrel to rotate by motor, drive sliding shoe to slide；
Described feed head is fixed on that motion that position in X-axis movement arm and Y-axis movement arm is higher
On the sliding shoe of arm.
13. multifunctional medical detectors as claimed in claim 1, it is characterised in that described reaction warehouse (3)
Heater block be cover reaction warehouse (3) bottom heating film, described heating film enables to reaction warehouse
(3) interior temperature stabilization controls at preset temperature.
14. multifunctional medical detectors as claimed in claim 1, it is characterised in that described multi-functional doctor
Treating detector and be additionally provided with waste holder (8), described waste holder (8) open top, described opening part is provided with
At least two panels shell fragment, the disposable tip (6) being used for blocking on feed head (102) makes feed head (102)
Separate with described disposable tip (6).
15. multifunctional medical detectors as claimed in claim 1, it is characterised in that described multi-functional doctor
Treat detector and also include suction nozzle box (7), in described suction nozzle box (7), be placed with disposable tip (6).
16. multifunctional medical detectors as claimed in claim 1, it is characterised in that described testing result
Processing module receives, by wired or wireless mode, the reflex response that described optical de-tection means (2) obtains
The voltage detecting value of magnitude of voltage and described electrode tip.
17. 1 kinds of multifunctional medical detecting systems, it is characterised in that described multifunctional medical detecting system bag
Include multifunctional medical detector as described in any one of claim 1-16 and multifunctional medical inspection as described in being placed in
Surveying the reagent disc (9) in instrument, described reagent disc (9) structure is circular, and described reagent disc (9) is along week
To being provided with some dryness analoidses (901) and/or some routine blood test detection components (902), described blood is normal
Rule detection components (902) include being loaded position, the micro-pipe being provided with micropore, control that sample in micro-pipe moves compacted
Dynamic pump and the detecting electrode being arranged on micropore.
18. multifunctional medical detecting systems as claimed in claim 17, it is characterised in that described reagent
Dish (9) also includes an optical correction diffusive reflective plate (903).
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| CN107271434A (en) * | 2016-04-08 | 2017-10-20 | 北京德鲁伊医疗器材有限公司 | A kind of multifunctional medical detector and multifunctional medical detecting system |
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| CN110368096A (en) * | 2019-08-13 | 2019-10-25 | 河南中医药大学 | Cerebrovascular diagnostic kit |
| CN110368096B (en) * | 2019-08-13 | 2020-06-02 | 河南中医药大学 | Cerebrovascular diagnosis kit |
| CN115584313A (en) * | 2022-12-09 | 2023-01-10 | 云南升玥信息技术有限公司 | Detection kit for detecting infectious agent sample |
| CN115584313B (en) * | 2022-12-09 | 2023-07-28 | 重庆高晋生物科技有限公司 | Detection kit for detecting infectious pathogen sample |
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