CN107271434A - A kind of multifunctional medical detector and multifunctional medical detecting system - Google Patents
A kind of multifunctional medical detector and multifunctional medical detecting system Download PDFInfo
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- CN107271434A CN107271434A CN201610218199.4A CN201610218199A CN107271434A CN 107271434 A CN107271434 A CN 107271434A CN 201610218199 A CN201610218199 A CN 201610218199A CN 107271434 A CN107271434 A CN 107271434A
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- Prior art keywords
- multifunctional medical
- reagent disc
- sample
- reaction warehouse
- detection
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/333—Ion-selective electrodes or membranes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/068—Optics, miscellaneous
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
Abstract
The present invention, which discloses a kind of multifunctional medical detector, includes sample charging mechanism, optical de-tection means, reaction warehouse, drive mechanism, electrode tip and testing result processing module；The drive mechanism has driving output shaft, and the driving output shaft is located in the middle part of the reaction warehouse, for driving the reagent disc spins in reaction warehouse；The optical de-tection means are located at below the reaction warehouse, rotation for following reagent disc, throw light is used for the dryness analoids of biochemistry detection at least one on the reagent disc successively, and the light reflected through the dryness analoids is received, obtain the reflex response magnitude of voltage of at least one biochemistry detection；The electrode tip is located at the top of reaction warehouse and with telescopic at least two electrode contacts, the electrode tip is used for the rotation for following reagent disc, the electrode on the electrode contacts contact reagent disc is passed sequentially through, to read the biochemistry detection of sample and/or the voltage detecting value of blood routine.Invention additionally discloses a kind of multifunctional medical detecting system.
Description
Technical field
The present invention relates to a kind of multifunctional medical detector and multifunctional medical detecting system.
Background technology
The medical detection means of body fluid or blood to people, can for clinically to disease diagnosis, treat with
And whether health status provides very favorable information foundation.Existing medical space such as hospital, clinic,
To the measure of the projects such as clinical biochemistry, clinical immunology, haemocyte technology, blood group, blood clotting, due to
Each instrument can only use a kind of methodology to detect, it is therefore desirable to while being equipped with a variety of instruments realizes detection, and
And, every kind of equipment instrument is larger, it is impossible to mobile, can only be completed by specialty detection teacher in the laboratory of specialty.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of degree of accuracy height, and reagent stability is good, structure
Simply, compact, portable multifunctional medical detector and its multifunctional medical detecting system.
The technical problem of the present invention is achieved through the following technical solutions：
As one aspect of the present invention, there is provided a kind of multifunctional medical detector, the multifunctional medical inspection
Surveying instrument is included at sample charging mechanism, optical de-tection means, reaction warehouse, drive mechanism, electrode tip and testing result
Manage module；
The reaction warehouse is used to place the reagent disc for carrying out biochemistry detection and/or blood routine detection, the reaction warehouse
Bottom is provided with heater block；
The drive mechanism has driving output shaft, and the driving output shaft is located in the middle part of the reaction warehouse, uses
Reagent disc spins in driving reaction warehouse；
The optical de-tection means are located at below the reaction warehouse, and the rotation for following reagent disc is thrown successively
Penetrate light is used for the dryness analoids of biochemistry detection at least one on the reagent disc, and receives through institute
The light of dryness analoids reflection is stated, the reflex response magnitude of voltage of at least one biochemistry detection is obtained；
The sample charging mechanism is used for for reagent disc sample-adding；
The electrode tip is located at the top of reaction warehouse and with telescopic at least two electrode contacts, the electricity
Cartridge is used for the rotation for following reagent disc, passes sequentially through the electrode on the electrode contacts contact reagent disc, with
Read the biochemistry detection of sample and/or the voltage detecting value of blood routine；
Testing result processing module, for the reflex response magnitude of voltage that is obtained according to the optical de-tection means and
The voltage detecting value of the electrode tip, biochemistry detection and/or the testing result of blood routine are obtained by calculating.
In one embodiment, the optical de-tection means include illuminating part, mirror lens, object lens, optical filtering
Wheel and daylighting portion；Position relationship between the illuminating part, mirror lens, object lens, filter wheel and daylighting portion
Meet：The light that illuminating part is sent is projected on the dryness analoids, institute after mirror lens reflects
The light for stating the reflection of dryness analoids projects daylighting portion by the object lens and filter wheel；
The daylighting portion is used to convert optical signals into corresponding reflex response magnitude of voltage.
In one embodiment, the optical de-tection means also include one of following plus lens or any group
Close：First plus lens, the second plus lens and the 3rd plus lens；
First plus lens is located between illuminating part and mirror lens；
Second plus lens is located between the mirror lens and reagent disc；
3rd plus lens is located between the filter wheel and daylighting portion.
In one embodiment, the daylighting portion includes：Photocell and be connected with the photocell electric current/
Voltage transformation module.
In one embodiment, the illuminating part includes：Constant current-supplying module, power output module, bulb,
Bulb internal resistance measurement feedback module；
The constant current-supplying module, power output module and bulb are sequentially connected；
The bulb internal resistance measurement feedback module connects the bulb and the power output module；
The power output module is used for the size of the internal resistance according to the bulb, adjusts the input of the bulb
Voltage.
In one embodiment, the drive mechanism includes being arranged on the motor of reaction warehouse bottom, described
The output shaft of motor is connected with external tooth gear, and the external tooth gear is placed in the middle part of reaction warehouse, for passing through
The reagent disc spins are driven with the internal-gear engaged transmission in reagent disc；
It is circumferentially arranged in the reaction warehouse to have at least three spacing guide wheels, for fixed in the reagent disc spins time limit
The position of pattern detection reagent disc.
In one embodiment, the drive mechanism includes being arranged on the motor of reaction warehouse bottom, described
Rotated coaxially between reagent disc and the output shaft of motor.
In one embodiment, the sample charging mechanism includes：Transmission mechanism and it is connected with the transmission mechanism
Feed head.
In one embodiment, the feed head includes：For pick up disposable tip syringe and with
Pressure sensor, controller and the sample-adding pump of the syringe connection；
The pressure sensor is used to detect the air pressure in the syringe；
The sample-adding pump is used to provide power when being loaded to reagent disc for syringe；
The controller is used for the air pressure detected according to the pressure sensor, enters with default voltage threshold
Row compares, and controls the air pressure in the syringe to reach the air pressure needed for current injector working condition；It is described
Working condition includes：Suction status, liquid relief state and sample-adding state.
Specifically, Ke Yishi, the controller is additionally operable to pick up disposable tip in the syringe of feed head
During, the air pressure in syringe is detected by the pressure sensor, determines whether disposable tip is damaged
Or block.
Specifically, Ke Yishi, the controller is additionally operable to pick up disposable tip in the syringe of feed head
During, the change of the air pressure in syringe is detected by the pressure sensor, determines whether deposited in sample
In bubble or grumeleuse.
In one embodiment, the transmission mechanism includes：X-axis movement arm, Y-axis movement arm and Z axis fortune
Swing arm；X-axis, Y-axis and Z axis are the reference axis in rectangular coordinate system in space；
The two ends of X-axis movement arm and Y-axis movement arm respectively with Z axis movement arm are connected；
Motor, the sliding shoe for connecting the screw mandrel of motor and being enclosed on screw mandrel are provided with each movement arm,
Rotated by motor drive screw, drive sliding shoe to slide；
The feed head is fixed on that motion that position is higher in both X-axis movement arm and Y-axis movement arm
On the sliding shoe of arm.
In one embodiment, the heater block of the reaction warehouse is the heating film for being covered in reaction warehouse bottom,
The heating film enables to temperature stabilization in reaction warehouse to control in preset temperature.
In one embodiment, the multifunctional medical detector is additionally provided with waste holder, the waste holder top
Provided with least two panels shell fragment at portion's opening, the opening, the disposable tip for blocking on feed head causes
Feed head is separated with the disposable tip.
In one embodiment, the multifunctional medical detector also includes putting in suction nozzle box, the suction nozzle box
It is equipped with disposable tip.
In one embodiment, the testing result processing module receives described by wired or wireless mode
Reflex response magnitude of voltage and the voltage detecting value of the electrode tip that optical de-tection means are obtained.
As another aspect of the present invention there is provided a kind of multifunctional medical detecting system, the multi-functional doctor
Treating detecting system includes the multifunctional medical detector described in any of the above-described and is placed in the multifunctional medical
Reagent disc in detector, the reagent dish structure is annular shape, and the reagent disc is circumferentially arranged some
Dryness analoids and/or some blood routine detection components, the blood routine detection components include sample-adding position, are provided with
The sample peristaltic pump moved and the detecting electrode being arranged on micropore in the micro-pipe of micropore, control micro-pipe.
In one embodiment, the reagent disc also includes an optical correction diffusive reflective plate.
Technical scheme provided in an embodiment of the present invention can at least realize following effect：
1st, multifunctional medical detector provided in an embodiment of the present invention can realize multiple detection projects at one
It can no longer need to use pure water when carrying out in equipment, also, biochemistry detection is carried out using dryness reagent, simplify
The detection process of traditional detection instrument so that detector can be with small-sized while testing result accuracy is ensured
Change, be easy to carry, in addition, the driving output shaft of drive mechanism is located at driving reaction warehouse in the middle part of the reaction warehouse
The mode of interior reagent disc spins, compared with the mode of belt transmission, can also make the total of detector enough tight
Gather, be convenient for carrying, so as to shorten the time expended from sampling, sample presentation and detection whole process, it is possible to achieve
Detection, family general practitioner detect that emergency first-aid etc. is pressed for time in patient family by the sick bed of clinical department
Anxious degree requires higher occasion, or even suitable for pet clinic.
2nd, the reagent disc drive mechanism that reaction warehouse is arranged in the embodiment of the present invention uses straight drive mode, transmission
Efficiency high, reagent disc drive position is more accurate.
3rd, can in reaction warehouse reagent disc rest area along the cylindrical circumferentially disposed some spacing guide wheels of reagent disc
Effectively limit the position of reagent disc, it is ensured that reagent disc will not shift in reaction warehouse.
4th, the illuminating part bulb of the optical de-tection means of the embodiment of the present invention uses constant current source power supply, by interior
It is amplified that bulb internal resistance variable signal is sent to power output module by resistance measurement comparison circuit in real time, changes
Output voltage, so that bulb intensity is basically unchanged, adds the service life of bulb.
5th, the daylighting portion of the optical de-tection means of the embodiment of the present invention uses I/V low noise high-gain amplifiers,
Influence of the amplifier self-noise to signal is reduced, the signal to noise ratio of output signal is improved, makes output signal
More stablize.
6th, biochemistry detection of the embodiment of the present invention replaces liquid reagent with reagent disc using dryness reagent card, all
Article needed for experiment is included in a piece of dryness reagent, environmental protection and is easy to preserve and is carried, and stably
Time is longer, and required specimen amount is less, meanwhile, traditional biochemical reaction method is remained again, detection
Chemical reaction is identical with traditional biochemical pattern or principle, improves the traceability of system, it is ensured that detection is tied
The accuracy of fruit.
7th, in the embodiment of the present invention, biochemistry detection replaces liquid reagent with reagent disc using dryness reagent card,
Without being diluted to sample, measurement error is reduced, the accuracy in detection and accuracy of instrument is improved.
8th, in the embodiment of the present invention, biochemistry detection provides reflecting background with reagent disc itself, without supporting
Cuvette and relevant apparatus, have simplified the structure of detector.
9th, liquid reagent is replaced using dryness analoids in the embodiment of the present invention, instrument is without setting liquid to try
Agent container, sample dilution device and supply and discharge water installations so that instrument overall volume reduces, and is easy to carry.
10th, the multifunctional medical detector of the embodiment of the present invention uses the reaction method of traditional detection, it is ensured that
Apparatus measures result and the measurement result of existing detector have comparability.
Brief description of the drawings
Accompanying drawing 1：Multifunctional medical detector structural representation provided in an embodiment of the present invention；
Accompanying drawing 2：Multifunctional medical detector structure top view provided in an embodiment of the present invention；
Accompanying drawing 3：Multifunctional medical detector structural side view provided in an embodiment of the present invention；
Accompanying drawing 4：Multifunctional medical detector optical de-tection means schematic diagram provided in an embodiment of the present invention；
Accompanying drawing 5：Optical de-tection means illuminating part schematic diagram provided in an embodiment of the present invention；
Accompanying drawing 6：Optical de-tection means daylighting portion schematic diagram provided in an embodiment of the present invention；
Accompanying drawing 7：Sample charging mechanism schematic diagram provided in an embodiment of the present invention；
Accompanying drawing 8：Biochemistry detection reagent disc structural representation provided in an embodiment of the present invention；
Accompanying drawing 9：Ion detection reagent disc structural representation provided in an embodiment of the present invention；
Accompanying drawing 10：Blood routine detection reagent dish structure schematic diagram provided in an embodiment of the present invention；
Accompanying drawing 11：The another structural representation of blood routine detection reagent disk provided in an embodiment of the present invention；
Accompanying drawing 12：The master control borad of multifunctional medical detector provided in an embodiment of the present invention is connected with each module to be shown
It is intended to；
Accompanying drawing 13：Multifunctional medical detector biochemistry detection sample concentration provided in an embodiment of the present invention and voltage
Value returns Line Chart；
Accompanying drawing 14：Certain laboratory medical equipment sample concentration provided in an embodiment of the present invention and the magnitude of voltage tropic
Shape figure；
Accompanying drawing 15：Multifunctional medical detector provided in an embodiment of the present invention and two medical detector ions are examined
Survey test specimen Concentration Testing Linear Comparison schematic diagram；
Accompanying drawing 16：Multifunctional medical detecting system schematic diagram provided in an embodiment of the present invention.
Embodiment
The invention will be further described with specific embodiment below in conjunction with the accompanying drawings, so that those skilled in the art
Member can be better understood from the present invention and can be practiced, but illustrated embodiment is not as the limit to the present invention
It is fixed.
As the specific embodiment of the present invention, shown in reference picture 1- Fig. 3, multifunctional medical detector,
Including sample charging mechanism 1, optical de-tection means 2, reaction warehouse 3, drive mechanism 4, electrode tip 5 and detection knot
Fruit processing module (is not illustrated) in figure；
The reaction warehouse 3 is used to place the reagent disc 9 for carrying out biochemistry detection and/or blood routine detection, described anti-
The bottom of storehouse 3 is answered to be provided with heater block；
The drive mechanism 4 has driving output shaft, and the driving output shaft is located at the middle part of reaction warehouse 3,
For driving the reagent disc spins in reaction warehouse 3；Drive mechanism 4 is set directly at the middle part of reaction warehouse 3,
Suitable for using the reagent disc spins directly controled in reaction warehouse processed, transmission efficiency, relative to belt transmission, examination
Agent disk drive position is more accurate.
The optical de-tection means 2 are located at below the reaction warehouse 3, the rotation for following reagent disc, according to
Secondary throw light is used for the dryness analoids of biochemistry detection at least one on the reagent disc, and receives
The light reflected through the dryness analoids, obtains the reflex response magnitude of voltage of at least one biochemistry detection；
The sample charging mechanism 1 is used for for reagent disc sample-adding；
The electrode tip 5 is located at the top of reaction warehouse 3 and with telescopic at least two electrode contacts, institute
The rotation that electrode tip 5 is used to follow reagent disc is stated, the electricity on the electrode contacts contact reagent disc is passed sequentially through
Pole, to read the biochemistry detection of sample and/or the voltage detecting value of blood routine；The electrode tip 5 can when working
To provide a predeterminated voltage, while different size of normal voltage can be provided according to different detection projects
Value, the standard voltage value can be 0 or other values.
Testing result processing module, for the reflex response magnitude of voltage that is obtained according to the optical de-tection means and
The voltage detecting value of the electrode tip, biochemistry detection and/or the testing result of blood routine are obtained by calculating.
As the specific embodiment of the present invention, shown in reference picture 4, the optical de-tection means 2 are wrapped
Include illuminating part 201, mirror lens 202, object lens 203, filter wheel 204 and daylighting portion 205；It is described luminous
Position relationship between portion 201, mirror lens 202, object lens 203, filter wheel 204 and daylighting portion 205 is expired
Foot：The light that illuminating part 201 is sent projects the dryness analoids after the reflection of mirror lens 202
On, the light of the dryness analoids reflection projects daylighting portion by the object lens 203 and filter wheel 204
205；
The daylighting portion 205 is used to convert optical signals into corresponding reflex response magnitude of voltage.
Specifically, it is also possible that the optical de-tection means 2 also include one of following plus lens or any
Combination：First plus lens 206, the second plus lens 207 and the 3rd plus lens 208；Described first
Plus lens 206 is located between illuminating part 201 and mirror lens 202；Second plus lens 207
Between the mirror lens 202 and reagent disc；3rd plus lens 208 is located at the filter wheel 204
Between daylighting portion 205.The optical de-tection means 2 of the multifunctional medical detector of the present invention can only be set
One or two kinds of in foregoing three kinds of plus lens, can also be provided with all above-mentioned three kinds of plus lens,
Appropriate selection can be made according to the space size of optical de-tection means 2 and the position relationship of each element.
More specifically, can be, shown in reference picture 5, the illuminating part 201, including：Constant current-supplying mould
Block, power output module, bulb, bulb internal resistance measurement feedback module；
The constant current-supplying module, power output module and bulb are sequentially connected；
Bulb internal resistance measurement feedback module connection bulb and power output module；
Power output module is used for the size of the internal resistance according to the bulb, adjusts the input voltage of bulb.
More specifically, can be, shown in reference picture 6, the daylighting portion 205, including：Photocell and with
The current/voltage-converted module of the photocell connection.
As a specific embodiment in the specific embodiment of the invention, shown in reference picture 4, illuminating part hair
Go out full wave light through the first plus lens 206, mirror lens 202 is irradiated to, by mirror lens 202
Useless infrared wavelength light is filtered, opening is arranged between the plus lens 207 of mirror lens 202 and second
Shutter 209, the light after reflection converges in the given zone of particular agent disk through the second saturating 207 mirror of convergence
Domain, the light reflected through reagent disc is eliminated after veiling glare by object lens 203, spy is obtained through filter wheel 204
The reflected light of standing wave length, finally through the 3rd plus lens 208, projects photocell, photocell believes light
Number being converted to voltage signal is output to testing result processing module.The dryness reagent of different colours on reagent disc
The light that piece is reflected, is eliminated after veiling glare by object lens 203, is incident upon on photocell so that photovoltage value
It is more accurate.
The bulb of the illuminating part 201 of the optical de-tection means 2 of the embodiment of the present invention uses constant current source power supply, leads to
Crossing internal resistance measurement comparison circuit, that bulb internal resistance variable signal is sent into power output module in real time is amplified,
Change output voltage, so that bulb intensity is basically unchanged, extend the service life of the bulb as consumptive material.
Shown in reference picture 6, the current/voltage-converted module of the daylighting portion 205 of optical de-tection means 2 is using I/V (electricity
Stream/voltage) low noise high-gain amplifier, put by constant current-supplying module to photocell and I/V low noise high-gains
Big device is powered the influence for reducing amplifier self-noise to signal, improves signal output module output signal
Signal to noise ratio, make output signal more stablize.By optimizing to illuminating part 201 and the component of daylighting portion 205,
The stabilization of light path is realized, obtained output signal is more accurate.
Shown in reference picture 1-3, the drive mechanism 4 includes being arranged on the motor 401 of the bottom of reaction warehouse 3,
The output shaft of the motor is connected with external tooth gear 402, and the external tooth gear 402 is placed in reaction warehouse 3
Middle part, referring again to shown in Fig. 8-Figure 10, reagent disc is annular shape, provided with interior on the inner periphery of reagent disc
External tooth gear 402 on gear, the output shaft of the motor 401 and the internal-gear on reagent disc
Engaged transmission drives reagent disc spins；
Specifically, it is circumferentially arranged in the reaction warehouse 3 to have at least three it is also possible that shown in reference picture 1
Individual spacing guide wheel 301, when being rotated under drive of the reagent disc in motor 401, at least three limit
Position guide wheel 301 limits the position of reagent disc, it is ensured that reagent disc will not shift in reaction warehouse.
As another specific embodiment of the specific embodiment of the invention, the drive mechanism can also be down
State structure：The drive mechanism includes being arranged on the motor of reaction warehouse bottom, the reagent disc and driving electricity
Rotated coaxially between the output shaft of machine.For example, at least one notch is provided with the reagent disc interior annular,
Correspond to the groove on the output shaft of motor and be provided with equal number of key, when reagent disc is placed on reaction
When in storehouse, groove clamping corresponding with the key so that reagent disc motor drive under with output
Axle is rotated coaxially.
It is used as a specific embodiment of the specific embodiment of the invention, shown in reference picture 1, the sample-adding machine
Structure 1 includes：Transmission mechanism 101 and the feed head 102 being connected with the transmission mechanism 101.
Specifically, Ke Yishi, shown in reference picture 7, the feed head 102 includes：It is disposable for picking up
The syringe of suction nozzle 6 and the pressure sensor being connected with the syringe, sample-adding pump and controller；
The pressure sensor is used to detect the air pressure in the syringe；
The sample-adding pump is used to provide power when being loaded to reagent disc for syringe；
The controller is used for the air pressure detected according to the pressure sensor, enters with default voltage threshold
Row compares, and controls the air pressure in the syringe to reach the air pressure needed for current injector working condition；It is described
Working condition includes：Suction status, liquid relief state and sample-adding state.
More specifically, can be, the controller be additionally operable to pick up disposable in the syringe of feed head 102
During suction nozzle 6, the air pressure in syringe is detected by the pressure sensor, determines that disposable tip is
No damaged or blocking.
More specifically, can be, the controller be additionally operable to pick up disposable in the syringe of feed head 102
During suction nozzle 6, the change of the air pressure in syringe is detected by the pressure sensor, is determined in sample
With the presence or absence of bubble or grumeleuse.
Specifically, Ke Yishi, shown in reference picture 1, the transmission mechanism 101 includes：X-axis movement arm,
Y-axis movement arm and Z axis movement arm；X-axis, Y-axis and Z axis are the reference axis in rectangular coordinate system in space；
The two ends of X-axis movement arm and Y-axis movement arm respectively with Z axis movement arm are connected；
Motor, the sliding shoe for connecting the screw mandrel of motor and being enclosed on screw mandrel are provided with each movement arm,
Rotated by motor drive screw, drive sliding shoe to slide；
Feed head is fixed on that higher movement arm of position in both X-axis movement arm and Y-axis movement arm
On sliding shoe.
The transmission mechanism of the present embodiment is linked by the cooperation of three-axis moving arm, and feed head is accurately moved to
Precalculated position.The transmission mechanism of the feed head of the embodiment of the present invention is not limited to the transmission in present embodiment
Feed head can be realized in mechanism, any space that can be limited when this multifunctional medical detector is loaded
It is applied to the present invention for the drive mechanism that reagent disc is loaded.
It is used as a specific embodiment of the embodiment of the present invention, shown in reference picture 1, the reaction
The heater block in storehouse 3 for example can be the heating film for being covered in the bottom of reaction warehouse 3, and the heating film is arranged on
The back side of the base of reaction warehouse 3, the heating film employs PID (PID) regulation, can be with
So that temperature stabilization control is in preset temperature in reaction warehouse 3.
It is used as a specific embodiment of the embodiment of the present invention, shown in reference picture 1, many work(
Energy medical detector is additionally provided with waste holder 8, the open top of waste holder 8, the opening provided with extremely
Few two panels shell fragment, for blocking the disposable tip 6 on feed head 102 so that feed head 102 and described one
Secondary property suction nozzle 6 is separated.
As a specific embodiment of the embodiment of the present invention, the multifunctional medical detector is also
Including suction nozzle box 7, disposable tip 6 is placed with the suction nozzle box 7.
As a specific embodiment of the embodiment of the present invention, the testing result processing module is led to
Cross wired or wireless mode and receive reflex response magnitude of voltage and the electricity that the optical de-tection means are obtained
The voltage detecting value of cartridge.
As a specific embodiment of the embodiment of the present invention, multifunctional medical detector also includes
Bar code information, can set Quick Response Code on reagent disc, be determined by scanning the Quick Response Code on reagent disc
The composition lot number and the term of validity of reagent disc.
As a specific embodiment of the embodiment of the present invention, multifunctional medical detector also includes
One master control borad, shown in reference picture 12, sample charging mechanism, the optical detector of the master control borad and detector
Between the modules such as structure, electrode tip, power supply using controller local area network (Controller Area Network,
CAN) bus mode is communicated.Display screen and button can be set on master control borad, by operating master control
The testing result of detector is fed back to testing result processing mould by plate to control each module of detector to work
Block (such as notebook computer, tablet personal computer or other have the terminal of computing function), testing result
Processing module is carried out by way of wired or wireless (such as bluetooth, WiFi, 3G) with master control borad
Communication.
It is provided in an embodiment of the present invention to carry out the multifunctional medical detector that biochemical and blood routine is detected, body
The small, integration degree of product is high, portable, easy to operate.Carried out separately below by 3 different embodiments
Explanation.
The embodiment of the present invention 1：
The present embodiment exemplified by biochemistry detecting item by illustrating：
Shown in reference picture 8, reagent disc is annular shape, multiple biochemical reagents pieces 901 is provided with above (multiple
Include uric acid biochemical reagents piece in biochemical reagents piece) and diffusive reflective plate 903, can be with the middle part of reagent disc
Provided with internal-gear, before on-test, reagent disc is taken out, appropriate time is placed and returns to after room temperature, will try
Agent disk is placed in the reaction warehouse 3 of above-mentioned multifunctional medical detector, in the driving machine of multifunctional medical detector
The output shaft of structure 4 is provided with the external tooth gear 402 that conjunction is mutually bitten with the internal-gear, is provided with reaction warehouse 3
Three spacing guide wheels 301, the position for limiting reagent disc.
Detection sample is taken to be placed in sample position, completing reagent disc by sample charging mechanism is loaded.It is loaded in sample-adding
The transmission mechanism 101 of mechanism 1 is driven by the motor on X-axis movement arm, Y-axis movement arm and Z axis movement arm
Dynamic screw mandrel drives sliding shoe to slide, so as to drive feed head to run to precalculated position.
When sample-adding work starts, transmission mechanism 101 drives feed head to the suction nozzle box of disposable tip 6 first
7 tops, disposable tip 6 is picked up by the syringe of feed head 102, in the pickup process of disposable tip 6
In, the pressure sensor of feed head 102 judges one according to the change of the atmospheric pressure in the syringe detected
The problems such as secondary property suction nozzle 6 is with the presence or absence of obstruction and gas leakage, pinpointing the problems to alarm.
Feed head 102 after pickup disposable tip 6 is moved to absorption sample at sample, draws the mistake of sample
Cheng Zhong, feed head 102 can be detected according to the change of pressure whether there is bubble in sample, the influence inspection such as grumeleuse
The material of survey.
Draw after the completion of sample, feed head 102 is moved to sample-adding position etc. under the drive of transmission mechanism 101
Wait to be loaded, in pipetting processes, the pressure sensor continuous firing of feed head 102 is detected in syringe
Pressure, such as pressure occur more than the fluctuation of predetermined threshold, stop liquid relief, and alarm.The meeting of feed head 102 exists
Sample is filled by sample-adding pump on each dry plate hole of reagent disc, often completes once to be loaded, reagent disc can be in driving
Next dry plate position is rotated under the drive of mechanism, is loaded again.Equally there is pressure during sample-adding
Power is detected, and perceives abnormal with the presence or absence of sample size, and the problems such as bubble, sample-adding can be stopped by pinpointing the problems, and
Alarm.
Shown in reference picture 7, in the course of work of feed head 102, pressure sensor can turn air pressure signal
Voltage signal output is changed to, voltage signal will be simulated by D/A conversion unit and believed after signal conditioning circuit
Number data signal is converted to, becomes the magnitude of voltage that controller can be read.Controller reads voltage letter in real time
Number, it is compared by the threshold value with being previously set, controls the air pressure in the syringe to reach current note
Air pressure needed for emitter working condition；Because equipment is during drawing sample and sample is added dropwise, storehouse is injected
Interior atmospheric pressure is different, so by monitoring the air pressure level in syringe in real time, passing through sample-adding
The work of pump, controls syringe precise operation under suction status, liquid relief state and sample-adding state.
It is loaded after the completion of work, reagent disc is in reaction warehouse by being covered in the heating film work of the bottom of reaction warehouse 3
Make temperature stabilization in control reaction warehouse 3 to be incubated in preset temperature.The preset temperature is 37 ± 0.1 DEG C
Temperature, simulation normal person's body temperature be incubated, allow required biochemical reaction to carry out, incubation time regarding specifically
Project and it is different, for example uric acid project incubation time be 5 minutes.
In reagent disc after the completion of sample incubation, detector is carried out respectively to each dryness analoids 901 of reagent disc
Optical detection.
By taking uric acid dryness analoids as an example, when optical detection starts, the bulb of illuminating part 201 sends all-wave
The light of section passes through the first plus lens 206, useless infrared wavelength light is filtered by mirror lens 202, instead
The second plus lens 207 is passed through after penetrating, is converged on the uric acid dryness analoids 901 of reagent disc, uric acid is done
Property the light that reflects of analoids 901 reflected light of specific wavelength is obtained by filter wheel, the reflected light is passed through
Daylighting portion 205, daylighting portion 205 are projected after object lens 203, the plus lens 208 of filter wheel 204 and the 3rd
Light intensity signal is converted into voltage signal and is delivered to master control borad, the reflected light of varying strength is radiated at photocell
On, different size of voltage can be produced.The voltage, will by D/A conversion unit after signal conditioning circuit
Analog signal is converted to data signal, becomes the signal that master control borad can be read.Master control borad is by the signal of reading
Testing result processing module is sent to by wired or wireless way, testing result processing module main frame passes through one
After serial analysis, the concentration of the biochemical indicator is drawn.
Detection experiment is completed, and feed head 102 can be moved to the top of waste holder 8, and feed head 102 is probeed into examination
The open top of agent box 8, provided with least two panels shell fragment at opening, for blocking the disposable suction on feed head
First 6, during feed head 102 is moved up at opening, feed head 102 will with it is described disposable
Suction nozzle 6 is separated.Experimenter opens hatch door, manually takes out used reagent disc, is put into the special modeling of discarded object
In pocket.
To ensure that detector analysis result is accurate, before detection on-test, it can use unrestrained on reagent disc
Reflector plate 903 carries out optical correction to the dry plate on reagent disc, and all band light sent by bulb is passed through respectively
Intensity of illumination when diffusive reflective plate 903 reflexes to daylighting portion 205 with dryness analoids 901 is different, calculates two
Person's light intensity difference, the light intensity value obtained in pattern detection experiment adds this difference, as dryness analoids 901
The actual light intensity value of reflected light.
Above-mentioned uric acid dryness analoids in the present embodiment, includes successively from top to bottom：Dispersion layer, reflecting layer,
Connecting layer, reagent layer and support layer；Wherein：The support layer is optical clear base material；The reagent layer master
Will be by uricase, peroxidase, 2- (3,5- dimethoxy-4 's-hydroxyphenyl) -4,5- to (4- dimethyl amines
Base phenyl) imidazoles, surfactant and fixative composition；The connecting layer is main by the dilute acyl of poly-N-isopropyl
Amine is constituted；The reflecting layer is mainly made up of white reflector material；The dispersion layer is main porous by what is bonded
Particulate and surfactant are constituted.
Further, mentioned reagent layer includes：Uricase, peroxidase, 2- (3,5- dimethoxy-4 's-
Hydroxyphenyl) -4,5- is to (4- dimethyl amidos phenyl) imidazoles, surfactant and fixative；
Above-mentioned connecting layer is the dilute acid amides of poly-N-isopropyl；
Above-mentioned reflecting layer is white reflector material；
Above-mentioned dispersion layer is the small porous particle and surfactant of bonding.
The Cleaning Principle of uric acid dryness analoids is：When sample drop to be detected is on uric acid dryness analoids
When, the uric acid being uniformly distributed in by diffusion layer in next layer, sample moves to reagent layer, in uricase
In the presence of, allantoin and hydrogen peroxide are oxidized to form, then, hydrogen peroxide is under peroxidase effect
Colourless stain is aoxidized, colored dyes is generated, is detected, finally may be used by the reflective light intensity to colored dyes
To analyze the biochemical concentration of uric acid.
Reagent layer reaction principle is as follows：
Above-mentioned diffusion layer main function is to form molecular sieve, allow sample be uniformly distributed under gravity and under
Ooze, the chaff interference for testing unrelated is also filtered in this layer.
Mentioned reagent layer contains a variety of dryness powder reagents, because sample is moved downward by gravity, examination
The structure of oxidant layer can efficiently control course of reaction.Reagent layer contains dryness dyestuff, detects final herein
Generation color change, and this layer is fixed on, to detect that light path is detected.
Above-mentioned connecting layer is the material of layer of gel class, its act on be prevent reacted color layer reagent to its
His layer spreads.
Above-mentioned support layer is one layer of optical clear base material, it is allowed to which the light of detection passes through, and it is above-mentioned to play support
The effect of each layer.Optical clear base material for example can for glass, polyethylene, polypropylene, polyvinyl chloride or
Polyester.
In one embodiment, the content of each component can have a variety of in reagent layer, such as following several：
Uricase 0.022U/cm2, peroxidase 0.4U/cm2, 2- (3,5- dimethoxy-4 's-hydroxyphenyl) -4,5-
To (4- dimethyl amidos phenyl) imidazoles 2cm2, surfactant 3.2mg/cm2With fixative 2.4mg/cm2。
Uricase 0.018U/cm2, peroxidase 0.8U/cm2, 2- (3,5- dimethoxy-4 's-hydroxyphenyl) -4,5-
To (4- dimethyl amidos phenyl) imidazoles 1cm2, surfactant 4.2mg/cm2With fixative 1.9mg/cm2。
Uricase 0.022U/cm2, peroxidase 0.8U/cm2, 2- (3,5- dimethoxy-4 's-hydroxyphenyl) -4,5-
To (4- dimethyl amidos phenyl) imidazoles 2cm2, surfactant 4.2mg/cm2With fixative 2.4mg/cm2。
Uricase 0.018U/cm2, peroxidase 0.4U/cm2, 2- (3,5- dimethoxy-4 's-hydroxyphenyl) -4,5-
To (4- dimethyl amidos phenyl) imidazoles 1cm2, surfactant 3.2mg/cm2With fixative 1.9mg/cm2。
Uricase 0.02U/cm2, peroxidase 0.6U/cm2, 2- (3,5- dimethoxy-4 's-hydroxyphenyl) -4,5-
To (4- dimethyl amidos phenyl) imidazoles 1.4cm2, surfactant 3.9mg/cm2With fixative 2.17mg/cm2。
The content of each component is not limited to above-mentioned example in mentioned reagent layer, is example above.
In one embodiment, above-mentioned fixative includes：Gelatin, hydrophilic cellulose derivatives, glucan,
Any of agarose, polyvinyl alcohol and polyacrylamide or above-mentioned any multiple combinations.
Surfactant can play the effect such as wetting, emulsification, scattered in reagent layer, promote sample fully,
Quickly chemically reacted with reactive material.
Above-mentioned 2- (3,5- dimethoxy-4 's-hydroxyphenyl) -4,5- are nothing to (4- dimethyl amidos phenyl) imidazoles
Color stain.
In one embodiment, the content of the dilute acid amides of poly-N-isopropyl is 2~5mg/cm in connecting layer2.Preferably
Ground, the content of the above-mentioned dilute acid amides of poly-N-isopropyl is 3mg/cm2。
In one embodiment, can be on reflecting layer it is any have high reflectance (for example reflectance factor exists
More than 95%) whiteness, above-mentioned white reflector material includes：Titanium dioxide, barium sulfate or the two
Mixture, the thickness in reflecting layer is 10~500 μm.It is preferred that the thickness in above-mentioned reflecting layer is 50~300
μm。
In one embodiment, the small porous particle in dispersion layer is titanium dioxide, barium sulfate, zinc oxide, oxygen
Change the particulate of lead, diatomite, microcrystalline cellulose or wherein any several mixtures.
The various particulates of dispersion layer can add surfactant and be bonded by the bonding agent of appropriate amount, for example
Bonded using acetate fiber.
A diameter of 1-7 μm of the particulate of dispersion layer, 30~500 μm of the thickness of the dispersion layer, porosity
25%~95%.
When small porous particle is titanium dioxide, the mass ratio of titanium dioxide and surfactant is：200:1~30:1.
Preserve, transport for convenience, above-mentioned uric acid dryness analoids can also include：Upper housing and lower housing,
Upper housing is located on dispersion layer, and lower housing is located under support layer, and is bonded between upper housing and lower housing.
Uric acid dryness analoids is fixedly installed on reagent disc, uric acid dryness analoids is loaded, then
Incubation time about 5 minutes at 37 DEG C, then can be in test requirements document in the optical detection portion of the lower section of reagent disc
Time respective wavelength filter (for example uric acid project be wavelength 670nm filter) to uric acid in reagent disc
The color of dryness analoids color layer carries out interpretation (reading intensity of reflected light), carried out during interpretation once or
Repeatedly read, uric acid project is end-point method, finally gives intensity of reflected light.Obtain after intensity of reflected light through dividing
Analysis obtains reflex response magnitude of voltage, and uric acid testing result value is obtained by the final calculating of detector.
Need to calibrate uric acid item detection project before.
Calibration process is as follows：
Calibration is completed in equipment with the calibration solution of concentration known.Calibration solution includes 3-5 water of test substance
Flat concentration, reads corresponding intensity of reflected light respectively in equipment, and each level reads 3-5 times and is averaged
Value.
Testing result calculation formula is in URIC uric acid projects：
N (detector magnitude of voltage)=K*ln (sample concentration)+b
Wherein, K is calibration curve slope, and b is the intercept of calibration curve
The calibration data in following table are obtained according to sample concentration and detector magnitude of voltage recurrence line chart, are carried out as follows
Calculate：
| Sample concentration | Detector magnitude of voltage | Ln (sample concentration) | Ln (detector magnitude of voltage) |
| 29.7 | 2.2056 | 3.391147046 | 0.790999581 |
| 223 | 2.1049 | 5.407171771 | 0.74426796 |
| 338.9 | 2.0756 | 5.825705079 | 0.730250269 |
| 595 | 2.0459 | 6.388561406 | 0.71583779 |
| 959.9 | 2.0234 | 6.866829112 | 0.704779265 |
0.79=3.68k+b
0.73=5.83k+b
0.70=6.86k+b
Obtain K=-0.0279 b=0.8927
The calibration curve for obtaining the project this batch is ln (magnitude of voltage)=- 0.0279*ln (sample concentration)
+0.8927
After calibrating successfully, the photovoltage value obtained according to specific test specimen is brought into above-mentioned calibration curve
Computing, just can obtain the concentration value of sample.
Ln r=0.7241 for example are obtained as the photovoltage value r=2.0628 measured, brings into formula and obtains：
Ln (sample concentration)=(0.7241-0.8927)/(- 0.0279)
It is computed showing that sample concentration value is 422mmol/l.
By the detector of the present invention and certain existing large-scale experiment room detection device comparing result, the He of reference picture 13
Figure 14 show the result that two instruments are measured several concentration known titers respectively, two chart more than
As can be seen that detection of the result of the detector of the present invention linearly with contrasting instrument is linearly basically identical, it is ensured that
The accuracy of testing result.
The embodiment of the present invention 2：
The present embodiment exemplified by the ion detection project in biochemistry detecting item by illustrating：
Shown in reference picture 9, it can be used in ion detection project comprising the reagent for ion detection part
Disk, the reagent disc is that some dryness analoidses 901 with multilayer film are included in annular shape, each reagent disc
A pair of electrodes 904 is provided with (being used to complete different kinds of ions detection project), each dryness analoids 901.
Internal-gear can be provided with the middle part of reagent disc, before on-test, ion detection project reagent disc is taken out,
Place appropriate time to return to after room temperature, by reagent disc load facility reaction warehouse 3.
By taking potassium ion detection project as an example, detection blood sample is taken, sample position is put into.Pass through sample charging mechanism 102
Disposable tip 6 is picked up, sample is picked up, each analoids sample-adding is completed in sample-adding position.Potassium in the present embodiment
The pickup of feed head 102 disposable tip 6 and sample in ion detection project, the process being loaded to reagent disc with
Process in embodiment 1 is consistent, will not be repeated here.
Complete after sample-adding, reagent disc can keep 37 ± 0.1 DEG C of temperature simulation normal person's body temperature in reaction warehouse
It is incubated, ion detection project incubation time is about 3 minutes.
After the completion of incubation, the electrode on the electrode contacts contact reagent disc dryness analoids of electrode tip reads examination
The voltage detecting value (the response potential of dryness analoids) of sample on agent disk, it should be noted that in ion
The standard voltage value that electrode tip itself does not provide voltage, i.e. electrode tip in detection project is 0.Electrode tip will be read
The voltage detecting result got, is delivered to master control borad, and the signal of reading is passed through wired or wireless side by master control borad
Formula is sent to testing result processing module, and testing result processing module is according to the response potential and predefines
The dryness analoids characteristic curve (reflection potassium concentration with response potential relation curve) draw
Potassium ion detection project test result.
Detection experiment is completed, and feed head 102 can be moved to the top of waste holder 8, and feed head 102 is probeed into examination
The open top of agent box 8, provided with least two panels shell fragment at opening, for blocking the disposable suction on feed head
First 6, during feed head 102 is moved up at opening, feed head 102 will with it is described disposable
Suction nozzle 6 is separated.Experimenter opens hatch door, manually takes out used reagent disc, is put into the special modeling of discarded object
In pocket.
Shown in Figure 15 be multifunctional medical detector provided in an embodiment of the present invention respectively with existing certain is large-scale
Laboratory testing equipment (be designated yiyong1 and be designated yiyong2) carries out ion detection item detection pair
Than result of the test, in figure, the lines comprising square are the result of the tests for the equipment for being designated yiyong1, bag
It is the result of the test for the equipment for being designated yiyong2 containing circular lines, the lines comprising triangle are to use
The result of the test of multifunctional medical detector provided in an embodiment of the present invention；A is that known sample is dense in loga
Degree, loga is exactly the logarithm value of concentration of specimens, and the knot of the detector of the present invention is can be seen that from above chart
Detection of the fruit linearly with contrasting instrument is linearly basically identical.
Potassium ion dryness analoids used in the present embodiment, for example, can include substrate, potassium ion and select
Electrode, salt bridge and insulating barrier.Potassium ion-selective electrode includes：Contact electrode, reaction electrode, solid state electrolysis
Matter reference layer, potassium ion selective membrane.
The preparation process of potassium ion dryness analoids comprises the steps in the present embodiment：
1st, use silk-screen printing technique in its surface printing silver paste on polyethylene terephthalate, prepare
Contact electrode.Printing equipment half tone is 200 mesh, 200 μm of print thickness, and condition of cure is：150 DEG C,
30min。
2nd, 2/3 section before dried contact electrode is aoxidized using chemical method.Specific oxidation step：Will
The contact electrode for aoxidizing position is needed to be immersed in 0.1mol/L ferric chloride solutions after 60s, taking-up is clear with pure water
Wash clean and drying, both obtain reaction electrode.
3rd, electrolyte reference layer coating.By 6g polyvinyl alcohol, 1g glycerine, 3g sodium chloride, 1g potassium chloride,
0.02g bactericide, 0.004g surfactants H212 is dissolved in 50g water, is applied with automatic coating machine
It is distributed on reaction electrode, 200 μm of coating thickness, coating speed 50mm/s, reference after reaction electrode coating
21 DEG C are positioned over after layer, 60min is dried under the environment of relative humidity 50%.
4th, potassium ion selective membrane is coated with.By 0.1g hydroxyvinyl resins, 0.1g ortho-nitrophenyl octyl ethers, 0.005g
Double [(benzene -15- crown ethers -4) -4 '-methyl] pimelates, 0.002g tetraphenylboron sodiums, 0.005g surfactants H212
It is dissolved in acetone, is coated on automatic coating machine on solid electrolyte reference layer, coating thickness 100
μm, coating speed 50mm/s, and drying at room temperature.
5th, after potassium ion selective membrane has been dried, prepared by potassium ion-selective electrode completes, and takes two panels potassium ion to select
Selecting electrode, (salt bridge is sealed among insulating barrier, for making ginseng by osmosis with insulating barrier and salt bridge respectively
Contacted with each other than liquid and test fluid, make the connection of two potassium ion-selective electrodes, form loop) on hole site
Align and use 705 silicon rubber to be bonded.
6th, after adhesive solidification, substrate edges are Nian Jie with the silicon rubber of insulating barrier edge 705, and adhesive is solid
After change prepared by potassium ion biochemical analysis dry plate to complete.
The embodiment of the present invention 3：
The present embodiment exemplified by blood routine project by illustrating：
Shown in reference picture 10 and Figure 11, it can be used in blood routine project with blood routine detection function
Reagent disc, the reagent disc is annular shape, the blood routine detection components 902 of reagent disc comprising multigroup sample-adding position,
Micro-pipe provided with micropore, in control micro-pipe the sample peristaltic pump moved, the detecting electrode that is arranged on micropore with
And waste collecting device, arrow show moving direction of the sample in micro-pipe in Figure 11.The reagent disc
Middle part can be provided with internal-gear, before on-test, take out blood routine detection project reagent disc, place suitable
After the time room temperature is returned to, by reagent disc load facility reaction warehouse.
Detection blood sample is taken, sample position is put into.Disposable tip 6, pickup are picked up by sample charging mechanism 102
Sample, each analoids sample-adding is completed in sample-adding position.Feed head 102 in the present embodiment intermediate ion detection project
Disposable tip 6 and sample are picked up, the process being loaded to reagent disc is consistent with the process in embodiment 1,
This is repeated no more.
Complete after sample-adding, there is dilution (physiological saline) to be diluted sample in reagent disc sample-adding position mixed
Even, reagent disc can keep 37 ± 0.1 DEG C of temperature simulation normal person's body temperature to be incubated in reaction warehouse, from
Sub- detection project incubation time is about 5 minutes.
Shown in reference picture 11, in the present embodiment, blood routine detection uses the high frequency method of sampling, its
Principle application is Coulter principle.Molecule be haemocyte in the medium of conductor solution by small
Hole, when adding constant-current source in hole both sides, can produce the minor variations of voltage, this change is with molecule
That is the diameter of haemocyte is relevant.There is the aperture of 2-5 microns of diameter in the reagent disc of blood count, by compacted
The pressure that dynamic pump is produced passes sequentially through the haemocyte after mixed diluting, and cell is by that can produce electricity during sensor
Pulse, after the electric signal is by high speed signal modulate circuit, is turned analog signal by high-speed digital-analog converting unit
Data signal is changed to, becomes the magnitude of voltage that controller can be read.Due to cell quantity greatly, corresponding arteries and veins
Very high frequency is rushed, the requirement for integrated circuit is higher.Master control borad will collect magnitude of voltage and upload to detection knot
A series of fruit processing module, after testing result processing module is by analyses, it can be deduced that various types of cells in blood
Count value.
Detect after on-test, the sample after dilution passes through micro- under the drive of reagent disc peristaltic pump along fine duct
Hole, now the electrode contacts of electrode tip contact detecting electrode on micropore, electrode tip applies a normal voltage,
Different haemocytes can cause different voltage pulses to change when by micropore, by measuring and analyzing these arteries and veins
Punching change and number of times, the blood routine project in blood of human body that can obtain need each numerical value detected, sample warp
Cross and waste collecting device is finally flowed into after micropore.
The present invention also provides a kind of multifunctional medical detecting system, shown in reference picture 16, the multi-functional doctor
Treating detecting system includes above-mentioned multifunctional medical detector and the examination being placed in the multifunctional medical detector
Agent disk 9, the structure of reagent disc 9 is annular shape, and the reagent disc 9 is circumferentially arranged to have some dryness to try
Agent piece 901 and/or some blood routine detection components 902, the blood routine detection components 902 include sample-adding position,
Micro-pipe provided with micropore, the sample peristaltic pump moved and the detection electricity being arranged on micropore in control micro-pipe
Pole.
Further, the reagent disc 9 also includes optical correction diffusive reflective plate 903 and/or some electricity
Pole 904.
Multifunctional medical detector in multifunctional medical detecting system provided in an embodiment of the present invention it is specific
Embodiment, can refer to the multifunctional medical detector described in previous embodiment, is no longer gone to live in the household of one's in-laws on getting married herein
State.
Embodiment described above is only the preferred embodiment to absolutely prove the present invention and being lifted, of the invention
Protection domain not limited to this.Equivalent substitute that those skilled in the art are made on the basis of the present invention or
Conversion, within protection scope of the present invention.Protection scope of the present invention is defined by claims.
Claims (18)
1. a kind of multifunctional medical detector, it is characterised in that the multifunctional medical detector includes adding
Model machine structure (1), optical de-tection means (2), reaction warehouse (3), drive mechanism (4), electrode tip (5)
With testing result processing module；
The reaction warehouse (3) is used to place the reagent disc (9) for carrying out biochemistry detection and/or blood routine detection,
Reaction warehouse (3) bottom is provided with heater block；
The drive mechanism (4) has driving output shaft, and the driving output shaft is located at the reaction warehouse (3)
Middle part, for driving the reagent disc spins in reaction warehouse (3)；
The optical de-tection means (2) are located at below the reaction warehouse (3), the rotation for following reagent disc
Turn, throw light is used for the dryness analoids of biochemistry detection at least one on the reagent disc successively,
And the light reflected through the dryness analoids is received, obtain the reflex response electricity of at least one biochemistry detection
Pressure value；
The sample charging mechanism (1) is used for for reagent disc sample-adding；
The electrode tip (5) is located at the top of reaction warehouse (3) and touched with telescopic at least two electrode
Point, the electrode tip (5) is used for the rotation for following reagent disc, passes sequentially through the electrode contacts contact examination
Electrode (904) on agent disk, to read the biochemistry detection of sample and/or the voltage detecting value of blood routine；
Testing result processing module, for the reflex response magnitude of voltage that is obtained according to the optical de-tection means and
The voltage detecting value of the electrode tip, biochemistry detection and/or the testing result of blood routine are obtained by calculating.
2. multifunctional medical detector as claimed in claim 1, it is characterised in that the optical detection
Mechanism includes illuminating part (201), mirror lens (202), object lens (203), filter wheel (204) and adopted
Light portion (205)；The illuminating part (201), mirror lens (202), object lens (203), filter wheel (204)
Position relationship between daylighting portion (205) is met：The light that illuminating part (201) is sent is saturating by reflection
After mirror (202) reflection, project on the dryness analoids, the light of the dryness analoids reflection leads to
Cross the object lens (203) and filter wheel (204) projects daylighting portion (205)；
The daylighting portion (205) is used to convert optical signals into corresponding reflex response magnitude of voltage.
3. multifunctional medical detector as claimed in claim 2, it is characterised in that the optical detection
Mechanism (2) also includes one of following plus lens or any combination：First plus lens (206), second
Plus lens (207) and the 3rd plus lens (208)；
First plus lens (206) is located between illuminating part (201) and mirror lens (202)；
Second plus lens (207) is located at the mirror lens (202) between reagent disc；
3rd plus lens (208) is located between the filter wheel (204) and daylighting portion (205).
4. multifunctional medical detector as claimed in claim 2 or claim 3, it is characterised in that the daylighting
Portion (205), including：Photocell and the current/voltage-converted module being connected with the photocell.
5. multifunctional medical detector as claimed in claim 2 or claim 3, it is characterised in that described luminous
Portion (201), including：Constant current-supplying module, power output module, bulb, bulb internal resistance measurement feedback mould
Block；
The constant current-supplying module, power output module and bulb are sequentially connected；
The bulb internal resistance measurement feedback module connects the bulb and the power output module；
The power output module is used for the size of the internal resistance according to the bulb, adjusts the input of the bulb
Voltage.
6. multifunctional medical detector as claimed in claim 1, it is characterised in that the drive mechanism
(4) motor (401) for being arranged on reaction warehouse (3) bottom, the motor (401) are included
Output shaft be connected with external tooth gear (402), the external tooth gear (402) is placed in the middle part of reaction warehouse (3),
For by driving the reagent disc spins with the internal-gear engaged transmission in reagent disc；
It is circumferentially arranged in the reaction warehouse (3) to have at least three spacing guide wheels (301), in reagent
The disc spins time limit determines the position of pattern detection reagent disc.
7. multifunctional medical detector as claimed in claim 1, it is characterised in that the drive mechanism
(4) motor (401) for being arranged on reaction warehouse (3) bottom, the reagent disc and motor are included
(401) rotated coaxially between output shaft.
8. multifunctional medical detector as claimed in claim 1, it is characterised in that the sample charging mechanism
(1) include：Transmission mechanism (101) and the feed head (102) being connected with the transmission mechanism (101).
9. multifunctional medical detector as claimed in claim 8, it is characterised in that feed head (102)
Including：For the pressure sensing for picking up the syringe of disposable tip (6) and being connected with the syringe
Device, controller and sample-adding pump；
The pressure sensor is used to detect the air pressure in the syringe；
The sample-adding pump is used to provide power when being loaded to reagent disc (9) for syringe；
The controller is used for the air pressure detected according to the pressure sensor, enters with default voltage threshold
Row compares, and controls the air pressure in the syringe to reach the air pressure needed for current injector working condition；It is described
Working condition includes：Suction status, liquid relief state and sample-adding state.
10. multifunctional medical detector as claimed in claim 9, it is characterised in that the controller is also
For during the syringe of feed head (102) pickup disposable tip (6), being passed by the pressure
Air pressure in sensor detection syringe, determines whether disposable tip (6) is damaged or blocks.
11. multifunctional medical detector as claimed in claim 9, it is characterised in that the controller is also
For during the syringe of feed head (102) pickup disposable tip (6), being passed by the pressure
The change of air pressure in sensor detection syringe, determines to whether there is bubble or grumeleuse in sample.
12. multifunctional medical detector as claimed in claim 8, it is characterised in that the transmission mechanism
(101) include：X-axis movement arm, Y-axis movement arm and Z axis movement arm；X-axis, Y-axis and Z axis are
Reference axis in rectangular coordinate system in space；
The two ends of X-axis movement arm and Y-axis movement arm respectively with Z axis movement arm are connected；
Motor, the sliding shoe for connecting the screw mandrel of motor and being enclosed on screw mandrel are provided with each movement arm,
Rotated by motor drive screw, drive sliding shoe to slide；
The feed head is fixed on that motion that position is higher in both X-axis movement arm and Y-axis movement arm
On the sliding shoe of arm.
13. multifunctional medical detector as claimed in claim 1, it is characterised in that the reaction warehouse (3)
Heater block be to be covered in the heating film of reaction warehouse (3) bottom, the heating film enables to reaction warehouse
(3) interior temperature stabilization control is in preset temperature.
14. multifunctional medical detector as claimed in claim 1, it is characterised in that the multi-functional doctor
Treatment detector, which is additionally provided with waste holder (8), waste holder (8) open top, the opening, to be provided with
At least two panels shell fragment, causes feed head (102) for blocking the disposable tip (6) on feed head (102)
Separated with the disposable tip (6).
15. multifunctional medical detector as claimed in claim 1, it is characterised in that the multi-functional doctor
Treating detector also includes being placed with disposable tip (6) in suction nozzle box (7), the suction nozzle box (7).
16. multifunctional medical detector as claimed in claim 1, it is characterised in that the testing result
Processing module receives the reflex response that the optical de-tection means (2) obtain by wired or wireless mode
The voltage detecting value of magnitude of voltage and the electrode tip.
17. a kind of multifunctional medical detecting system, it is characterised in that the multifunctional medical detecting system bag
Include multifunctional medical detector as described in claim any one of 1-16 and be placed in the multifunctional medical and examine
The reagent disc (9) surveyed in instrument, reagent disc (9) structure is annular shape, and the reagent disc (9) is along week
To some dryness analoidses (901) and/or some blood routine detection components (902) are provided with, the blood is normal
Advise detection components (902) include sample-adding position, the micro-pipe provided with micropore, control micro-pipe in sample move it is compacted
Dynamic pump and the detecting electrode being arranged on micropore.
18. multifunctional medical detecting system as claimed in claim 17, it is characterised in that the reagent
Disk (9) also includes an optical correction with diffusive reflective plate (903).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610218199.4A CN107271434A (en) | 2016-04-08 | 2016-04-08 | A kind of multifunctional medical detector and multifunctional medical detecting system |
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| CN108717113A (en) * | 2018-05-29 | 2018-10-30 | 陈金凤 | A kind of bio-chemical detector |
| CN108732097A (en) * | 2018-05-29 | 2018-11-02 | 陈金凤 | A kind of optical detection apparatus of medicine bio-chemical detector |
| CN110208212A (en) * | 2019-07-04 | 2019-09-06 | 中南林业科技大学 | A kind of comprehensive non-destructive testing device of near infrared spectrum and control method |
| CN110393852A (en) * | 2019-08-20 | 2019-11-01 | 江苏工大博实医用机器人研究发展有限公司 | A kind of radioactive prospecting instrument is pushed pin working state monitoring system |
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