CN204981893U - Formula cell culture reactor sways - Google Patents
Formula cell culture reactor sways Download PDFInfo
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- CN204981893U CN204981893U CN201520493613.3U CN201520493613U CN204981893U CN 204981893 U CN204981893 U CN 204981893U CN 201520493613 U CN201520493613 U CN 201520493613U CN 204981893 U CN204981893 U CN 204981893U
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Abstract
The utility model provides a formula cell culture reactor sways, include: the controller, with the formula of the swaing reaction structure that the controller is connected, bearing controller and the bearing structure of swaing formula reaction structure to and respectively with sway the feed supplement structure that formula reaction structure and controller are connected, sway formula reaction structure including sway power source unit, with two at least trays that power source unit links to each other and is used for the fixation reaction bag sway, sway power source unit and include the power supply device, with the power shaft that the power supply device is connected, the power shaft has the tray sliding shaft via the conducting subassembly sliding connection that does all can, two at least tray intervals set up and fixed connection power conducting subassembly to a reaction bag sways for doing all can on the conducting subassembly drives when coming and going the slip on the tray sliding shaft and is fixed in the tray. The way of this device make full use of space layering has reduced area with the hierarchical control of a plurality of reactions bag, concentrates the controller, integrate simultaneously, has reduced area and administrative cost for scale cell culture.
Description
Technical field
The utility model is related to a kind of rocking equipment for placing cell culture bags, the dynamic cultivation for zooblast.
Background technology
Currently with the mode of cell culture bags culture cell, it is mainly used in the culture of suspension cell, incubation because nutrient solution is static in static placement, cell growth process, thus nutrient solution consumes propagation that is unbalanced and then limiting cell.Therefore in order to obtain higher cell density, it is necessary to by cell culture mobilism.Current dynamic cell culture system has stirring-type, roller bottle formula, shaking-table and swing.Stirring-type culture is mainly used in suspension cell culture, or microcarrier is added in nutrient solution, attached cell is attached to grown on microcarriers, to increase cell growth surface product, cell is cultivated under stirring condition, the shearing force or rotor of the formation of liquid stream easily cause damage to cell.Roller bottle formula culture is mainly used in the culture of attached cell, is that can increase the surface area for cell attachment using the advantage of roller bottle culture, while gentle rotation is conducive to cell growth.When blake bottle is rotated, cell leaves nutrient solution for some time, is suspended in aerial, the exchange of its gas, favourable cell growth are added, but cost is high if roller bottle is disposable, cleaning, sterilization link are added if being used for multiple times, while adding the probability of pollution.Shaking-table culture then needs shaking table module being fitted in CO2gas incubator, complex structure, and somewhat expensive increases the cost of culture apparatus.Single swing culture device is had both at home and abroad, and each reaction bag is individually controlled by a controller, and floor space is limited during large-scale culture, and equipment investment is big, manages the problems such as inconvenience.
Utility model content
The purpose of this utility model is to provide a kind of swing cell culture reactor, it is connected by swing reaction structure with multiple pallets, power is provided by power source device, the power passes to multiple pallets by swing reaction structure, so that multiple pallets drive different cell culture bags to teeter formula motion respectively, and the device is from the temperature and peristaltic pump of controller control reaction bag toward each reaction bag feed rate and time.Therefore, the device takes full advantage of space, reduces floor space, is that scale cell culture reduces floor space and management cost while controller is concentrated, integrated.
A kind of swing cell culture reactor, including：Controller, the swing reaction structure being connected with controller, the mounting structures of controller and swing reaction structure described in support, and the feed supplement structure being connected respectively with the swing reaction structure and controller；The swing reaction structure includes nosing force source unit, is connected with the nosing force source unit and is used at least two pallets of fixing reaction bag, the nosing force source unit includes power source device, the line shaft being connected with power source device, the line shaft slidably connects tray both slid axle via power conducting subassembly；Pallet interval setting described at least two and the power conducting subassembly is fixedly connected, is come and gone for the power conducting subassembly on tray both slid axle and drive the reaction bag being fixed on the pallet to wave when sliding.
Preferably, the line shaft is screw mandrel；The power conducting subassembly, which includes be connected with the screw mandrel, and the slide unit parallel to the tray both slid axle and longitudinally spaced row are located in the plate face of the installing plate of the slide unit at least two first holds axle, and first holds axle and be slidably connected to the tray both slid axle respectively and be movably connected with the pallet described at least two.
Preferably, the line shaft is screw mandrel；The power conducting subassembly, which includes be connected with the screw mandrel, and the slide unit parallel to the tray both slid axle and longitudinally spaced row are located in the plate face of the installing plate of the slide unit at least two first holds axle；The nosing force source unit also includes the auxiliary axis of guide set parallel to the tray both slid axle and is slidably connected described aiding in the axis of guide and holding axle with first holds that axle is connected respectively at least two second, described first, which holds axle and described second, holds bridging between axle and has pallet connector, and the auxiliary axis of guide coordinates the tray both slid axle make it that direction of the pallet along the auxiliary axis of guide swings back and forth.
Preferably, the line shaft is screw mandrel；The power conducting subassembly includes being connected with the screw mandrel and parallel to the slide unit of the tray both slid axle；The slide unit has an installing plate, in longitudinally spaced row in the plate face of the installing plate provided with multiple connecting plates with the installing plate right-angled intersection, being respectively arranged at two ends with for the connecting plate first holds axle, the middle part of the connecting plate is provided with the first pallet connector, second pallet connector of the pallet provided with correspondence connection the first pallet connector；The number of the tray both slid axle is two, and axle corresponding first is held in the be slidably connected respectively two ends of the connecting plate of two tray both slid axles.
Preferably, the power source device is motor.
Preferably, the mounting structures include support platform and the sliding element moved located at support mesa base for the support platform towards direction of advance.
Preferably, the sliding element includes multiple Universal pulleys, and the Universal pulley is moved or mobile locking provided with locating part for support platform.
Preferably, heating element heater is inlayed for the fluid temperature in the reaction bag in the bottom of the pallet.
Preferably, the feed supplement structure includes the peristaltic pump and the flow control element on the liquid-transport pipe-line being connected via liquid-transport pipe-line with the reaction bag, and the flow control element is connected via wire with the controller.
Swing cell culture reactor provided by the utility model, provides power, the power passes to multiple pallets via power conducting subassembly by power source device so that multiple pallets drive different cell culture bags to teeter formula motion respectively.And the device, which to be realized, control the temperature of multiple reaction bags from a controller and control peristaltic pump toward each reaction bag feed rate and time.This device makes full use of the method for space delamination by multiple reaction bag hierarchical controls, reduces floor space, is that scale cell culture reduces floor space and management cost while controller is concentrated, integrated.
Brief description of the drawings
Fig. 1 is the schematic appearance that the swing cell culture reactor of the utility model is not provided with mounting structures；
Fig. 2 is the exploded view of swing reaction structure in the swing cell culture reactor of the utility model；
Fig. 3 is the front view of nosing force source unit in the swing cell culture reactor of the utility model；
Fig. 4 is the side view of nosing force source unit in the swing cell culture reactor of the utility model；
Fig. 5 is the structural representation of reaction bag in the swing cell culture reactor of the utility model；
Fig. 6 is the structural representation of pallet in the swing cell culture reactor of the utility model；
Fig. 7 is the decomposing schematic representation of the first pallet connector in the swing cell culture reactor of the utility model；
Fig. 8 is the structural representation of connecting plate in the swing cell culture reactor of the utility model；
Fig. 9 is the stereogram of mounting structures in the swing cell culture reactor of the utility model.
Embodiment
For the benefit of to the understanding of structure of the present utility model, illustrated below in conjunction with drawings and Examples.
Embodiment 1：
With reference to shown in Fig. 1 to Fig. 9, the utility model provides a kind of swing cell culture reactor, and the reactor is in a body structure, including：Controller 10 on cabinet shell, the swing reaction structure 20 being connected with controller 10, swing reaction structure 20 is in the cavity of body structure, the mounting structures 30 of controller 10 and swing reaction structure 20 described in support, and the feed supplement structure being connected respectively with the swing reaction structure 20 and controller 10.
The swing reaction structure 20 includes nosing force source unit 21, is connected with the nosing force source unit 21 and is used at least two pallets 22 of fixing reaction bag 50, the nosing force source unit 21 includes power source device 211, the line shaft 212 being connected with power source device 211, the line shaft 212 slidably connects tray both slid axle 214 via power conducting subassembly 213.The interval setting of pallet 22 described at least two and the power conducting subassembly 213 is fixedly connected, is come and gone for the power conducting subassembly 213 on tray both slid axle 213 and drive the reaction bag 50 being fixed on the pallet 22 to wave when sliding.
Further, the line shaft 213 is screw mandrel, and the power conducting subassembly 213 includes being connected with the screw mandrel and parallel to the slide unit 2131 of the tray both slid axle.The slide unit 2131 has an installing plate 21311, in longitudinally spaced row in the plate face of the installing plate 21311 provided with multiple connecting plates 2132 with the right-angled intersection of installing plate 21311, being respectively arranged at two ends with for the connecting plate 2,132 first holds axle 2133, the middle part of the connecting plate 2132 is provided with the first pallet connector 2134, and the first pallet connector 2134 includes the first expansion plate for being fixedly connected on the middle part of connecting plate 2132 and rotates the second expansion plate being connected with the first expansion plate.Second pallet connector 221 of the pallet 22 provided with correspondence connection the first pallet connector 2132.In the present embodiment, the number of the second pallet connector 221 on each pallet 22 is two, is divided into the two ends of the same side wall of pallet 22.In addition, the number of the tray both slid axle 214 is two, axle 2133 corresponding first is held in the be slidably connected respectively two ends of the connecting plate 2132 of two tray both slid axles 214.In the present embodiment, the pallet 22 is square disk body, inlays heating element heater in the bottom of pallet 22, the heating element heater is connected to control the fluid temperature in the reaction bag 50 with the controller 10.Further, the power source device 211 is motor.In a particular application, controller 10 includes：Touch-screen and the electric cabinet of control, control parameter and instruction are inputted by touch-screen to controller 10, and the control elements such as control element, PLC and power supply are installed by controlling electric cabinet.Mounted controller 10 swings up and down amplitude and cycle by programme-control pallet, by the temperature of PID programme-control reaction bags, by programme-control peristaltic pump toward each reaction bag feed rate and time.
Reaction bag 50 is made of compound FDA diaphragm, reaction bag 50 and other disposable parts using preceding, it is necessary to be sterilized by radiated by gamma-ray.Reaction bag 50 is fixed on pallet when using, squeeze into bag sterile cell and nutrient solution are sterile, being set in the control interface of controller 10 needs the control parameters such as the amplitude waved and acid-base value, temperature, and reaction bag internal environment is automatically controlled by controller 10.
The mounting structures 30 include support platform 31 and the sliding element 32 moved located at support mesa base for the support platform towards direction of advance.Further, the sliding element 32 includes multiple Universal pulleys, and is moved in Universal pulley provided with locating part for support platform or mobile locking.
The feed supplement structure includes the peristaltic pump and the flow control element on the liquid-transport pipe-line being connected via liquid-transport pipe-line with the reaction bag, and the flow control element is connected via wire with the controller 10.
Embodiment 2：
The utility model provides a kind of swing cell culture reactor, including：Controller, the swing reaction structure being connected with controller, the mounting structures of controller and swing reaction structure described in support, and the feed supplement structure being connected respectively with the swing reaction structure and controller.
The swing reaction structure includes nosing force source unit, is connected with the nosing force source unit and is used at least two pallets of fixing reaction bag, the nosing force source unit includes power source device, the line shaft being connected with power source device, the line shaft slidably connects tray both slid axle via power conducting subassembly.Pallet interval setting described at least two and the power conducting subassembly is fixedly connected, is come and gone for the power conducting subassembly on tray both slid axle and drive the reaction bag being fixed on the pallet to wave when sliding.
Further, the line shaft is screw mandrel, the power conducting subassembly, which includes be connected with the screw mandrel, and the slide unit parallel to the tray both slid axle and longitudinally spaced row are located in the plate face of the installing plate of the slide unit at least two first holds axle, and first holds axle and be slidably connected to the tray both slid axle respectively and be movably connected with the pallet described at least two.In the present embodiment, the pallet is square disk body, inlays heating element heater in the bottom of pallet, the heating element heater is connected to control the fluid temperature in the reaction bag with the controller.Further, the power source device is motor.In a particular application, reaction bag is made of compound FDA diaphragm, reaction bag and other disposable parts using preceding, it is necessary to be sterilized by radiated by gamma-ray.Reaction bag is fixed on pallet when using, squeezed into bag sterile cell and nutrient solution are sterile, the control parameters such as the amplitude and acid-base value, temperature that need to wave are set in the control interface of controller, reaction bag internal environment is automatically controlled by controller.
The mounting structures include support platform and the sliding element moved located at support mesa base for the support platform towards direction of advance.Further, the sliding element includes multiple Universal pulleys, and is moved in Universal pulley provided with locating part for support platform or mobile locking.
The feed supplement structure includes the peristaltic pump and the flow control element on the liquid-transport pipe-line being connected via liquid-transport pipe-line with the reaction bag, and the flow control element is connected via wire with the controller.
Embodiment 3：
The utility model provides a kind of swing cell culture reactor, including：Controller, the swing reaction structure being connected with controller, the mounting structures of controller and swing reaction structure described in support, and the feed supplement structure being connected respectively with the swing reaction structure and controller.
The swing reaction structure includes nosing force source unit, is connected with the nosing force source unit and is used at least two pallets of fixing reaction bag, the nosing force source unit includes power source device, the line shaft being connected with power source device, the line shaft slidably connects tray both slid axle via power conducting subassembly.Pallet interval setting described at least two and the power conducting subassembly is fixedly connected, is come and gone for the power conducting subassembly on tray both slid axle and drive the reaction bag being fixed on the pallet to wave when sliding.
Further, the line shaft is screw mandrel, and the power conducting subassembly, which includes be connected with the screw mandrel, and the slide unit parallel to the tray both slid axle and longitudinally spaced row are located in the plate face of the installing plate of the slide unit at least two first holds axle；The nosing force source unit also includes the auxiliary axis of guide set parallel to the tray both slid axle and is slidably connected described aiding in the axis of guide and holding axle with first holds that axle is connected respectively at least two second, described first, which holds axle and described second, holds bridging between axle and has pallet connector, and the auxiliary axis of guide coordinates the tray both slid axle make it that direction of the pallet along the auxiliary axis of guide swings back and forth.In the present embodiment, the pallet is square disk body, inlays heating element heater in the bottom of pallet, the heating element heater is connected to control the fluid temperature in the reaction bag with the controller.Further, the power source device is motor.In a particular application, reaction bag is made of compound FDA diaphragm, reaction bag and other disposable parts using preceding, it is necessary to be sterilized by radiated by gamma-ray.Reaction bag is fixed on pallet when using, squeezed into bag sterile cell and nutrient solution are sterile, the control parameters such as the amplitude and acid-base value, temperature that need to wave are set in the control interface of controller, reaction bag internal environment is automatically controlled by controller.
The mounting structures include support platform and the sliding element moved located at support mesa base for the support platform towards direction of advance.Further, the sliding element includes multiple Universal pulleys, and is moved in Universal pulley provided with locating part for support platform or mobile locking.
The feed supplement structure includes the peristaltic pump and the flow control element on the liquid-transport pipe-line being connected via liquid-transport pipe-line with the reaction bag, and the flow control element is connected via wire with the controller.
The control details to the swing cell culture reactor of the utility model is described in detail below.
Controller 10 includes touch-screen and the electric cabinet of control, and control parameter and instruction are inputted to controller by touch-screen, and the control elements such as control element, PLC and power supply are installed by controlling electric cabinet.Mounted controller 10 swings up and down amplitude and cycle by programme-control pallet 22, inlay heating element heater to realize the temperature control to reaction bag by the bottom of PID programme-control pallet 22, by programme-control flow control element, finally to control peristaltic pump toward each reaction bag feed rate and time.
The power conduction details to the swing cell culture reactor described in the utility model embodiment 1 is described in detail below.
Refer to shown in Fig. 1 to Fig. 9, motor is opened by controller 10, motor 211 drives screw mandrel (line shaft 212) to rotate, the junction of slide unit 2131 and screw mandrel 212 is provided with the internal thread for match screw mandrel, when screw mandrel 212 is rotated the installing plate 21311 of drive slide unit 2131 on screw mandrel along screw axis to back and forth movement.Because longitudinally spaced row is provided with multiple connecting plates 2132 with the right-angled intersection of installing plate 21311 in the plate face of installing plate 21311, the first of the two ends of each connecting plate 2132 holds axle 2133 and is slidably connected respectively with corresponding tray both slid axle 214, when the longitudinal back and forth movement of installing plate 21311, the first of the two ends of connecting plate 2132 are driven to hold the back and forth movement on corresponding tray both slid axle 214 of axle 2133.And, the middle part of the connecting plate 2132 is rotated with the second pallet connector 221 on the pallet 22 by the first pallet connector 2134 and is connected, when the longitudinal back and forth movement of connecting plate 2132 so that the reaction bag 50 on pallet 22 swings back and forth up and down in certain angle.
Swing cell culture reactor provided by the utility model, provides power, the power passes to multiple pallets via power conducting subassembly by power source device so that multiple pallets drive different cell culture bags to teeter formula motion respectively.And the device, which to be realized, control the temperature of multiple reaction bags from a controller and control peristaltic pump toward each reaction bag feed rate and time.This device makes full use of the method for space delamination by multiple reaction bag hierarchical controls, reduces floor space, is that scale cell culture reduces floor space and management cost while controller is concentrated, integrated.
The utility model is described in detail above in association with accompanying drawing embodiment, those skilled in the art can make many variations example to the utility model according to the above description.Thus, some of embodiment details, which should not be constituted, to be limited of the present utility model, and the utility model regard the scope defined using appended claims as protection domain.
Claims (9)
1. a kind of swing cell culture reactor, it is characterised in that including：Controller, the swing reaction structure being connected with controller, the mounting structures of controller and swing reaction structure described in support, and the feed supplement structure being connected respectively with the swing reaction structure and controller；
The swing reaction structure includes nosing force source unit, is connected with the nosing force source unit and is used at least two pallets of fixing reaction bag, the nosing force source unit includes power source device, the line shaft being connected with power source device, the line shaft slidably connects tray both slid axle via power conducting subassembly；Pallet interval setting described at least two and the power conducting subassembly is fixedly connected, is come and gone for the power conducting subassembly on tray both slid axle and drive the reaction bag being fixed on the pallet to wave when sliding.
2. swing cell culture reactor according to claim 1, it is characterised in that
The line shaft is screw mandrel；
The power conducting subassembly, which includes be connected with the screw mandrel, and the slide unit parallel to the tray both slid axle and longitudinally spaced row are located in the plate face of the installing plate of the slide unit at least two first holds axle, and first holds axle and be slidably connected to the tray both slid axle respectively and be movably connected with the pallet described at least two.
3. swing cell culture reactor according to claim 1, it is characterised in that
The line shaft is screw mandrel；
The power conducting subassembly, which includes be connected with the screw mandrel, and the slide unit parallel to the tray both slid axle and longitudinally spaced row are located in the plate face of the installing plate of the slide unit at least two first holds axle；
The nosing force source unit also includes the auxiliary axis of guide set parallel to the tray both slid axle and is slidably connected described aiding in the axis of guide and holding axle with first holds that axle is connected respectively at least two second, described first, which holds axle and described second, holds bridging between axle and has pallet connector, and the auxiliary axis of guide coordinates the tray both slid axle make it that direction of the pallet along the auxiliary axis of guide swings back and forth.
4. swing cell culture reactor according to claim 1, it is characterised in that
The line shaft is screw mandrel；
The power conducting subassembly includes being connected with the screw mandrel and parallel to the slide unit of the tray both slid axle；
The slide unit has an installing plate, in longitudinally spaced row in the plate face of the installing plate provided with multiple connecting plates with the installing plate right-angled intersection, being respectively arranged at two ends with for the connecting plate first holds axle, the middle part of the connecting plate is provided with the first pallet connector, second pallet connector of the pallet provided with correspondence connection the first pallet connector；
The number of the tray both slid axle is two, and axle corresponding first is held in the be slidably connected respectively two ends of the connecting plate of two tray both slid axles.
5. swing cell culture reactor as claimed in any of claims 2 to 4, it is characterised in that the power source device is motor.
6. swing cell culture reactor according to claim 5, it is characterised in that the mounting structures include support platform and the sliding element moved located at support mesa base for the support platform towards direction of advance.
7. swing cell culture reactor according to claim 6, it is characterised in that the sliding element includes multiple Universal pulleys, the Universal pulley is moved or mobile locking provided with locating part for support platform.
8. swing cell culture reactor according to claim 7, it is characterised in that heating element heater is inlayed in the bottom of the pallet, the heating element heater is connected to control the fluid temperature in the reaction bag with the controller.
9. swing cell culture reactor according to claim 8, it is characterized in that, the feed supplement structure includes the peristaltic pump and the flow control element on the liquid-transport pipe-line being connected via liquid-transport pipe-line with the reaction bag, and the flow control element is connected via wire with the controller.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520493613.3U CN204981893U (en) | 2015-07-09 | 2015-07-09 | Formula cell culture reactor sways |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201520493613.3U CN204981893U (en) | 2015-07-09 | 2015-07-09 | Formula cell culture reactor sways |
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| CN204981893U true CN204981893U (en) | 2016-01-20 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105567566A (en) * | 2016-03-08 | 2016-05-11 | 上海吉凯基因科技有限公司 | Culture bag bracket for continuous cell culture rocking device |
| CN105567565A (en) * | 2016-03-08 | 2016-05-11 | 上海吉凯基因科技有限公司 | Continuous cell culture rocking device |
| CN109863240A (en) * | 2016-10-31 | 2019-06-07 | 通用电气公司 | Biological respinse device assembly |
| CN114517156A (en) * | 2022-02-14 | 2022-05-20 | 飞鼎智造(上海)生物科技有限公司 | Swing device of swing type bioreactor |
-
2015
- 2015-07-09 CN CN201520493613.3U patent/CN204981893U/en active Active
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105567566A (en) * | 2016-03-08 | 2016-05-11 | 上海吉凯基因科技有限公司 | Culture bag bracket for continuous cell culture rocking device |
| CN105567565A (en) * | 2016-03-08 | 2016-05-11 | 上海吉凯基因科技有限公司 | Continuous cell culture rocking device |
| CN109863240A (en) * | 2016-10-31 | 2019-06-07 | 通用电气公司 | Biological respinse device assembly |
| US11525113B2 (en) | 2016-10-31 | 2022-12-13 | Global Life Sciences Solutions Usa Llc | Bioreactor assembly |
| CN114517156A (en) * | 2022-02-14 | 2022-05-20 | 飞鼎智造(上海)生物科技有限公司 | Swing device of swing type bioreactor |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Formula cell culture reactor sways Effective date of registration: 20171221 Granted publication date: 20160120 Pledgee: Guangzhou Caold financing Company limited by guarantee Pledgor: Guangzhou Qizhi Biology Engineering Equipment Co., Ltd. Registration number: 2017440000196 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20181116 Granted publication date: 20160120 Pledgee: Guangzhou Caold financing Company limited by guarantee Pledgor: Guangzhou Qizhi Biology Engineering Equipment Co., Ltd. Registration number: 2017440000196 |
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| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of utility model: Formula cell culture reactor sways Effective date of registration: 20181212 Granted publication date: 20160120 Pledgee: Guangzhou Caold financing Company limited by guarantee Pledgor: Guangzhou Qizhi Biology Engineering Equipment Co., Ltd. Registration number: 2018440000363 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20220321 Granted publication date: 20160120 Pledgee: Guangzhou Caold financing Company limited by guarantee Pledgor: GUANGZHOU QIZHI BIOLOGICAL ENGINEERING EQUIPMENT CO.,LTD. Registration number: 2018440000363 |
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| PC01 | Cancellation of the registration of the contract for pledge of patent right |