CN203803512U - Device capable of rapidly dehydrating and fixing biomolecule detection sample - Google Patents
Device capable of rapidly dehydrating and fixing biomolecule detection sample Download PDFInfo
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- CN203803512U CN203803512U CN201320669686.4U CN201320669686U CN203803512U CN 203803512 U CN203803512 U CN 203803512U CN 201320669686 U CN201320669686 U CN 201320669686U CN 203803512 U CN203803512 U CN 203803512U
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- fast dewatering
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Abstract
The utility model discloses a device capable of rapidly dehydrating and fixing a biomolecule detection sample and an application method of the device. The device mainly comprises a cylindrical bottle and a round thread port bottle cap, wherein the cylindrical bottle is 25-60 mm in diameter and 35-75 mm in height; a sample storage container is placed in the bottle or the bottle cap; filter paper, a cavernous body and a biomolecule protective agent are placed in the sample storage container; an assistant bag containing a drying agent, porous spongy foam or a deoxidizing agent is placed at the lower part of the bottle; an isolation device is arranged between the assistant bag and the sample storage container to prevent the assistant from polluting the sample; a plurality of air holes are formed in the isolation device to enable the assistant bag to play the roles of drying, dehydration and the like. The device capable of rapidly dehydrating and fixing the biomolecule detection sample can rapidly dry the biological sample, enables the sample to be stored for a long time, and has a broad application prospect.
Description
Technical field:
The utility model relates to a kind of device for biomolecule Sample storage.
Background technology:
The main component of blood of human body is blood plasma and haemocyte.The inorganic salts that contain in blood plasma, products of cellular metabolism, hormone, enzyme and antibody etc. have important physiological function, have carried the health and fitness information of human body.Haemocyte can be divided into red blood cell, leucocyte, blood platelet, and red blood cell has ABO type antigen, is some hemopathic diagnosis, curative effect judgement and one of estimation and the indexs such as anaemia; Leucocyte is the colourless sphaerocyst that has core that volume ratio red blood cell is slightly large, and leukocytic quantity can reflect the health status of human body; Blood platelet has specific morphosis and biochemical composition, in the physiology such as hemostasis, wound healing, inflammatory reaction, thrombosis and organ-graft refection and pathologic process, plays an important role.Therefore, the physiological change of organism and pathological change often cause the change of blood constituent, so the detection of blood constituent has important clinical meaning.
Urine be the mankind and vertebrate in metabolic processes, due to the needs of body, the liquid discharges excreting via urinary system and urinary tract.The health that in urine, entrained information can reflect human body whether, is also in the activities such as important sports events, the index whether sportsman's illegal drug is used.Urine examination is a very important clinically trial inspection, urine examination process is had relatively high expectations to the preservation of the sample of collecting, because place red blood cell and the leucocyte in urine after several hours after urine sample takes out, be just damaged, glucose is decomposed etc. by bacterium, affects the accuracy of check result.The requirement that urine examination sample in important sports events need to be preserved is preserved and is reached the several years, as the detection in later stage.Therefore, need a kind of store method fast and effectively, to guarantee the accuracy of testing result.
In addition, other various body fluid, as saliva, seminal fluid, and the cell in artificial bio-membrane's sample, nutrient solution, extract etc., before detection, all need through storing and processing, therefore, it is particularly important that the preservation of sample seems.
With the store method of blood testing sample in prior art, detecting is at present by adding the method for anticorrisive agent, glass seasoning and freeze-drying etc. to preserve with blood testing samples such as serum.The shortcoming of this store method is apparent: the method term of validity that 1, adds anticorrisive agent to preserve only has two weeks, easily grows mould meeting contaminated samples, the active ingredient in sample is changed, thereby affect the accuracy of result of use and testing result.2, freeze-drying is in freezing and dry process, and the low temperature of moment makes the volume of sample and surface pressure occur to change rapidly, and the molecule in sample is caused to damage.3, in conventional detection, for doing for the sample of different test items respectively, preserve, work loaded down with trivial details and complicated.Therefore seeking a kind of sample product for the treatment of that can be quick, stable under normal temperature condition preserves respectively and seems particularly important.
Utility model content:
The utility model has solved that sample is contaminated in preservation process, the molecule in sample is subject to damage and sample can not rapid saving etc. technical problem, the sample product for the treatment of that the utility model can be quick, stable under normal temperature condition are preserved respectively.
Fast dewatering fixing biological molecules detects a device for sample, is a kind of rapid draing design box, comprising: cylindrical bottle, and diameter is 25～60mm, height is 35～75mm; Circular wire mouth bottle cap; In bottle or bottle cap, be provided with sample reservoir vessel, be placed with filter paper, the cavernous body with certain water absorbing capacity, the biomolecule protective agent being formed by trehalose, maltose, maltodextrin, HES etc. and a small amount of glycerine; Bottle bottom is placed with auxiliary agent bag; Between auxiliary agent bag and sample reservoir vessel, there is spacer assembly; On spacer assembly, a plurality of air-vents can be set, air-vent is circle, ellipse or rectangle, and auxiliary agent bag comprises: one or more drier, porous spongy foam or deoxidier.Deoxidier can, at porous spongy foam inside, can be also independently.
The material of quick-drying design box of the present utility model is the material with good biocompatibility.In preservation process, can not produce sample is had to the gas of pollution and powder etc.Quick-drying design box material can adopt polyethylene (PE), polypropylene (PP), polymethyl methacrylate (PMMA, be commonly called as lucite), Merlon (PC), polyurethane (PU), polytetrafluoroethylene (PTFE) (Teflon, PTFE) or PETG (PET, PETE).Drier can be selected calcium chloride, calcium sulfate, magnesium chloride, silica gel, molecular sieve or montmorillonite.Deoxidier is selected technique of activated ferrous powder with, vitamin C, enzyme deoxidier or photaesthesia dyestuff.Macromolecular material selects natural, semi-synthetic and synthesized polymer material as PLA (PLA, PLLA), poly-alkanoic acid ester (PHAs), shitosan, alginic acid etc.
The utility model has the following advantages: 1, the utility model design box material is the material with good biocompatibility, in preservation process, can sample not produced and be polluted.2, because sample does not directly contact with auxiliary agents such as drier, can not cause damage to the molecule in sample.3, for doing for the sample of different test items while preserving respectively, can accomplish rapid saving.The utility model can be quick, stable under normal temperature condition the sample product for the treatment of preserve respectively.
Marginal data:
Below in conjunction with drawings and Examples, the utility model is further illustrated.Wherein:
Fig. 1: liquid biological sample rapid draing box schematic diagram of the present invention: the 11 silk mouthful bottle caps with micro slide, 12 is the micro slide on silk mouthful bottle cap, and 13 is the brace of silk mouthful bottle cap and micro slide, and 14 is drier dividing plate, and 15 is air-vent, 16 is auxiliary agent bag.
Fig. 2: solid biologic sample rapid draing box schematic diagram of the present invention: 21 is silk mouthful bottle cap, and 22 is shuttle air-vent, and 23 is solid sample container, and 24 is solid sample, and 25 is auxiliary agent bag, and 26 is division board.
The specific embodiment:
Embodiment 1:
Quick-drying design box comprises: cylindrical bottle, and diameter is 35mm, height is 48mm; Circular wire mouth bottle cap 11, a silk mouthful bottle cap 11 contains a plurality of micro slides 12; Micro slide 12 is comprised of filter paper, the cavernous body with certain water absorbing capacity, contains trehalose, maltose, maltodextrin, HES etc. and a small amount of glycerine as the protective agent of biomolecule; A plurality of micro slides 12 interconnect with adhesive means by brace 13, and brace is connected with bottle cap 11, and connected mode is the methods such as gluing, clamping, clip; In order to prevent auxiliary agent, to the pollution of sample, can establish the division board 14 that diameter is identical with cylindrical bottle internal diameter; A plurality of air-vents 15 are set on division board 14, and air-vent is shaped as circle, ellipse or rectangle, in division board outer rim, is arranged in order; Auxiliary agent bag 16 is placed on bottle bottom.
Embodiment 2:
Quick-drying design box comprises: cylindrical bottle, and diameter is 35mm, height is 48mm; Circular wire mouth bottle cap 21; In bottle, be provided with groove shape solid sample container 23, its edge is slightly larger than bottleneck diameter, thereby is connected with bottleneck in the mode of clamping; Solid sample container 23 is provided with shuttle air-vent 22, is shaped as circle, ellipse or rectangle, at solids container sidewall, is from top to bottom staggered, and the solid sample 24 of collection can be placed in solid sample container 23; Auxiliary agent bag 25 is placed on bottle bottom.
Claims (7)
1. fast dewatering fixing biological molecules detects a device for sample, it is characterized in that, comprises following structure: cylindrical bottle, and diameter is 25～60mm, height is 35～75mm; Circular wire mouth bottle cap (11,21); In bottle or bottle cap, be provided with sample reservoir vessel (12,23), on described reservoir vessel (12,23), be placed with the protective agent of filter paper, cavernous body and the biomolecule with certain water absorbing capacity; Bottle bottom is placed with auxiliary agent bag (16,25); Between described auxiliary agent bag (16,25) and described sample reservoir vessel (12,23), there is spacer assembly (14,26); On described spacer assembly (14,26), be provided with air-vent (15,22).
2. fast dewatering fixing biological molecules as claimed in claim 1 detects the device of sample, it is characterized in that: described bottle material is polyethylene, polypropylene, polymethyl methacrylate, Merlon, polyurethane, polytetrafluoroethylene (PTFE) or PETG.
3. fast dewatering fixing biological molecules as claimed in claim 1 detects the device of sample, it is characterized in that: described auxiliary agent bag (16,25) comprising: drier, porous spongy foam or deoxidier; Described drier is calcium chloride, calcium sulfate, magnesium chloride, silica gel, molecular sieve or montmorillonite; Described deoxidier is technique of activated ferrous powder with, vitamin C, enzyme deoxidier or photaesthesia dyestuff.
4. fast dewatering fixing biological molecules as claimed in claim 3 detects the device of sample, it is characterized in that: deoxidier is at porous spongy foam inside.
5. fast dewatering fixing biological molecules as claimed in claim 3 detects the device of sample, it is characterized in that: it is outside that deoxidier is independent of porous spongy foam.
6. fast dewatering fixing biological molecules as claimed in claim 1 detects the device of sample, it is characterized in that: protectant composition of biomolecule is trehalose, maltose, maltodextrin, HES or glycerine.
7. the fast dewatering fixing biological molecules as described in as arbitrary in claim 1～6 detects the device of sample, it is characterized in that: described air-vent (15,22) is circular, ellipse or rectangle.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320669686.4U CN203803512U (en) | 2013-10-25 | 2013-10-25 | Device capable of rapidly dehydrating and fixing biomolecule detection sample |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320669686.4U CN203803512U (en) | 2013-10-25 | 2013-10-25 | Device capable of rapidly dehydrating and fixing biomolecule detection sample |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203803512U true CN203803512U (en) | 2014-09-03 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320669686.4U Expired - Fee Related CN203803512U (en) | 2013-10-25 | 2013-10-25 | Device capable of rapidly dehydrating and fixing biomolecule detection sample |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN203803512U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103706411A (en) * | 2013-10-25 | 2014-04-09 | 无锡灵锡医疗器械科技有限公司 | Device for rapid dehydration and of fixing biological molecule detection sample and method |
-
2013
- 2013-10-25 CN CN201320669686.4U patent/CN203803512U/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103706411A (en) * | 2013-10-25 | 2014-04-09 | 无锡灵锡医疗器械科技有限公司 | Device for rapid dehydration and of fixing biological molecule detection sample and method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140903 Termination date: 20171025 |