CN202875351U - Vacuum blood sampling tube capable of directly separating serum - Google Patents
Vacuum blood sampling tube capable of directly separating serum Download PDFInfo
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- CN202875351U CN202875351U CN 201220397683 CN201220397683U CN202875351U CN 202875351 U CN202875351 U CN 202875351U CN 201220397683 CN201220397683 CN 201220397683 CN 201220397683 U CN201220397683 U CN 201220397683U CN 202875351 U CN202875351 U CN 202875351U
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Abstract
The utility model relates to the technical field of clinical medical instruments, in particular to a vacuum blood sampling tube capable of directly separating serum. The vacuum blood sampling tube capable of directly separating the serum comprises a blood sampling tube body, an inner tube, a rubber plug and a filter element and is characterized in that the inner tube of the blood sampling tube is arranged inside the blood sampling tube body, the rubber plug is arranged at the top of the blood sampling tube body, the structure of the rubber plug is similar to a plug shape, a semi-round groove is formed in the middle of the upper portion of the rubber plug structure, the left end and the right end of the lower portion of the rubber plug are embedded into the blood sampling tube body and connected with an inner tube of the blood sampling tube, a serum outlet is formed in the middle of the bottom of the inner tube of the blood sampling tube, a serum collecting chamber is arranged on the lower portion of the serum outlet, a filter film is arranged on the upper portion of the serum outlet of the inner tube of the blood sampling tube, the filter element is arranged on the upper portion of the filter film and is further provided with a buffer piece, a blood sampling chamber is formed in the inner tube of the blood sampling tube, and a layer of coagulant is arranged on the inner wall of the inner tube of the blood sampling tube. According to the vacuum blood sampling tube capable of directly separating the serum, through physical form differences between blood visible components and serum components, the serum can be separated rapidly, and the vacuum blood sampling tube capable of directly separating the serum is simple, safe and rapid.
Description
[technical field]
This utility model relates to clinical treatment technique with the apparatus field, specifically a kind of directly vacuum test tube of separation of serum.
[background technology]
The detection of blood preparation is the routine techniques means of medical institutions' Clinical Laboratory, the blood preparation that is used for in-vitro diagnosis mainly is divided into arterial blood and venous blood, the arterial blood specimen is mainly used in the blood gas index analysis clinically, and the detection range of application of venous blood specimen is quite extensive, as learn index, hemorheology index, blood routine analysis, trace element and ion component analysis, nutritional labeling detection, detection of drug concentration, gene test, the detection of infectious disease nosetiology, microorganism detection etc. for detection of biochemical indicator, blood clotting.Because the different differences that detect detecting instrument that index is used, the venous blood specimen is divided into again serum, blood plasma and whole blood three classes according to purposes.The acquisition of serum specimen mainly is the approach by centrifugalize traditionally, after the process of solidifying through a natural coagulation or coagulant catalysis after blood exsomatizes, isolates serum by centrifuge reaching under the condition of certain centrifugal force.
Vacuum test tube common in the prior art is comprised of blood taking tube body, plug and skull, additive, label etc., itself do not have the function of direct separation of serum, if needing separation of serum must finish by centrifuge after blood sampling, so need after the blood sampling through the regular hour treat blood solidify fully after ability centrifugalize serum, but this technology exists many weak points, may form haemolysis if the centrifugal condition grasp is improper, perhaps cause the breakage of collection container in the centrifugal process, cause specimen seepage or fully damage; In addition, in centrifugal process and after separating, serum and blood clot mix, and under the effect that is subject to centrifugal force or in the process of depositing, endoerythrocytic material can be discharged in the serum, thereby final testing result is impacted, and is safe and reliable not.
[summary of the invention]
This utility model is exactly in order to solve in the prior art blood collection container directly deficiency and the defective of separation of serum, and a kind of novel structure, the safe and reliable directly vacuum test tube of separation of serum are provided.
For achieving the above object, a kind of directly vacuum test tube of separation of serum is provided, comprise the blood taking tube body, inner tube, plug, filter element, the top that it is characterized in that described blood taking tube body is provided with plug, the structure proximate of plug is the plug shape, the center upper portion of plug structure is provided with semi-circular recesses, two ends, the left and right sides, plug bottom embed to connect the blood taking tube body and are connected with blood taking tube inner tube in the blood taking tube body, be provided with the serum flow export in the middle of the bottom of blood taking tube inner tube, the bottom of serum flow export is the serum collecting chamber, top at blood taking tube inner tube serum flow export is provided with filter membrane, the top of filter membrane is provided with filter element, also be provided with buffer substrate tablet on the described filter element, in the blood taking tube inner tube, consist of by the Blood Sampling Room between filter element top to the blood taking tube inner tube top thus, the inwall of blood taking tube inner tube is provided with one deck coagulant, described coagulant comprises thrombin, snake venom extract, cephalin, ellagic acid, aminocaproic acid, ethylenediamine diaceturate, thromboplastinum, rabbit brain powder, silicon dioxide, kaolin, silicate, aluminate, or by the synthetic derivant of above-mentioned material, complex.
Described blood taking tube body is by one or more compound the making in glass, polyester plastic cement, the macromolecular material.
The manufactured materials of described its body of blood taking tube inner tube is mainly macromolecular material, comprises high density polyethylene (HDPE), Low Density Polyethylene, polypropylene, polystyrene, Merlon, polyethylene, terephthalate.
The manufactured materials of described filter element comprises ultra-fine Plant fiber, artificial synthetic fiber, polyester sintered product, filter paper, optimization polypropylene synthetic fibers, polyethylene synthetic fibers, polyethylene terephthalate synthetic fibers, carboxymethyl cellulose, microcrystalline Cellulose, the Plant fiber through processing.
The material of described plug comprises natural rubber, halogenated butyl rubber, synthetic rubber, thermoplastic elastomer (TPE).
Described filter element top is provided with one deck buffer substrate tablet, and the padded coaming of buffer substrate tablet comprises coagulant tabletting, kaolin tabletting, coagulant ball, nylon membrane, filter paper, the synthetic cellulose film of lyophilizing, also is provided with the coagulant of one deck coating on the buffer substrate tablet.
Described filter membrane is microporous filter membrane, and its manufactured materials comprises cellulose acetate, celluloid, mixed cellulose ester, nylon 6, nylon 66, Kynoar, politef, polyether sulfone, polypropylene material.
The utility model has the advantage of the physical aspect difference of utilizing blood formed element and serum component, utilize the simple ratio juris sharp separation serum that filters, have easy, safe, characteristics fast, need not directly to isolate qualified serum by traditional centrifugal machine, for Clinical detection.Be transparent tube body but also the negative pressure that can effectively guarantee vacuum test tube after its material that adopts is not only made, material is easy to obtain, and cost is low, and is effective, economical and practical, safe and reliable.
[description of drawings]
Fig. 1 is the primary structure sketch map of this utility model vacuum test tube;
Fig. 2 is the partial enlarged drawing of a part among this utility model Fig. 1;
As shown in the figure, among the figure: 1. blood taking tube body 2. serum collecting chambers 3. filter membranes 4. filter elements 5. buffer substrate tablets 6. blood taking tube inner tubes 7. coagulant 8. Blood Sampling Rooms 9. plugs 10. serum flow exports;
Specifying Fig. 1 is Figure of abstract of the present utility model.
[specific embodiment]
The utility model is described in further detail below in conjunction with accompanying drawing, and the structure of this device and principle are very clearly concerning this professional people.Should be appreciated that specific embodiment described herein only is used for explaining this utility model, and be not used in restriction this utility model.
This utility model provides a kind of directly vacuum test tube of separation of serum, need to just can not obtain qualified serum by other equipment.
Its principle of vacuum test tube of this directly separation of serum is to utilize serum different from the physical aspect of blood formed element, in inner tube that filter element is housed of the inner installation of blood taking tube, the blood taking tube interior separation is become Blood Sampling Room and serum collecting chamber, by coagulant and the filter element that is built in the blood taking tube inner tube, make the blood rapid solidification that flows into Blood Sampling Room, blood clot after solidifying is kept off at an upper portion thereof by filter element, it is Blood Sampling Room, and serum composition can flow into the bottom of blood taking tube smoothly by filter element, it is the serum collecting chamber, thereby serum and blood clot are separated, and the plug of extracting the blood taking tube that is connected to blood taking tube inner tube upper end discards whole blood taking tube inner tube and can use the serum specimen of serum collecting chamber to be used for various detections.
As shown in Figures 1 and 2, this utility model mainly is comprised of blood taking tube body, blood taking tube inner tube, filter element, these several parts of plug, and blood taking tube inside is separated into up and down two parts space by inner tube, and top is Blood Sampling Room, and the bottom is the serum collecting chamber.
The blood taking tube body is made by glass, plastics or other macromolecular materials, is round bottom or the point end, flat tubular structure, end sealing, other end opening.There is an inner tube that is filled with filter element blood taking tube body inside, and inner tube is made by plastic cement or other macromolecular materials, and an end is connected with plug towards upper shed, and the other end is hollow T shape structure, and the bottom has the serum flow export; The external diameter of inner tube is slightly less than the internal diameter of blood taking tube body, the assembling after and the blood taking tube inwall fit tightly; Filter element is made by Plant fiber, synthetic fibers or polyester sintered material, filter paper material, and its aperture can only filter serum less than blood formed element, can not pass through other blood constitutents and coagulant component; The inwall of inner tube scribbles coagulant, blood enter after the inner tube can be under the effect of coagulant rapid solidification, coagulant also can be sprayed on and place filter element top on the other material; Padded coaming is put as the coagulant carrier in the top of filter element, and filter membrane is put in the bottom of filter element, and the liquid that further filter element is flowed out refilters, to guarantee the quality of serum.The plug of blood taking tube is made by elastomeric material, can seal the opening of blood taking tube body fully, guarantees that vacuum test tube inside can preset certain negative pressure, and vacuum in the holding tube within a certain period of time.The bizet bulging of the plug of blood taking tube or externally put safety head is easy to extract after use, and the centre of pipe lid has circular groove, blood taking needle puncture when being convenient to take a blood sample; Plug and body contact portion have two aspects, the external diameter of last layer face and blood taking tube internal diameter of tube body coupling, can guarantee to manage interior vacuum, the external diameter of next aspect and inner tube diameter coupling, and certain interference is arranged, can guarantee after serum leaches, plug to be extracted from the blood taking tube body together with whole inner tube.
The material of making the blood taking tube body comprises silicate glass, borate glass, soda-lime glass, polyester plastic material, macromolecular material, preferred boric acid salt glass, polyethylene terephthalate, poly ethyldiol modified polyethylene terephthalate, Merlon, poly-naphthalene dicarboxylic acid glycol ester or polyethylene terephthalate and poly-naphthalene dicarboxylic acid glycol ester composite.Because be transparent tube body but also the negative pressure that can effectively guarantee vacuum test tube after above-mentioned material is not only made, material is easy to obtain, and cost is relatively cheap.The material of making the inner tube body comprises the macromolecular materials such as high density polyethylene (HDPE), Low Density Polyethylene, polypropylene, polystyrene, Merlon, polyethylene terephthalate, preferred high density polyethylene (HDPE), its inner tube of making is comparatively transparent and soft, can fit with the blood taking tube inwall on the one hand, in blood taking tube, take out comparatively easily later in the serum filtering on the other hand.
The coagulant of inner tube wall spraying comprises thrombin, snake venom extract, cephalin, ellagic acid, aminocaproic acid, ethylenediamine diaceturate, thromboplastinum, rabbit brain powder, silicon dioxide, kaolin, silicate, aluminate, or the derivant, the complex that have above-mentioned material to synthesize, preferred thrombin, because its not only blood coagulation speed is fast, and can the subsequent detection index that obtain serum not impacted.
The material of making filter element comprises ultra-fine Plant fiber, artificial synthetic fiber, polyester sintered product, filter paper, optimization polypropylene synthetic fibers, polyethylene synthetic fibers, polyethylene terephthalate synthetic fibers, carboxymethyl cellulose, microcrystalline Cellulose, the Plant fiber through processing, such as degreasing cotton, the preferred micron order product in the aperture of superfine fibre, preferably polyethylene terephthalate synthetic fibers, this fiber can not form haemolysis, can be in conjunction with the target detection component in the blood.The material of making the plug of blood taking tube comprises natural rubber, halogenated butyl rubber, synthetic rubber, thermoplastic elastomer (TPE), preferred halogenated butyl rubber, not only be easy to molding, and possess enough elasticity and can effectively guarantee the vacuum that blood taking tube presets, after use, also be easy to extract.
The filter element top can add a padded coaming, is coated with coagulant on the material, and the blood that so at first flows into blood taking tube can mix with coagulant rapidly, is conducive to the blood rapid solidification.Padded coaming comprises coagulant tabletting, kaolin tabletting, coagulant ball, nylon membrane, filter paper, the synthetic cellulose film of lyophilizing, coagulant ball or the coagulant sheet preferably made by the tabletting of making after the coagulant lyophilizing that contains thrombin, by cephalin and kaolin mixture, the effect of padded coaming is that anti-Hemostatic Oral Liquid does not touch when flowing into Blood Sampling Room at the beginning and is sprayed on the coagulant on the tube wall and flowed directly into filter element, so that blood is difficult to rapid solidification, cause the serum can not sharp separation.The filter element below can add one deck filter membrane, filter membrane is round sheet, its external diameter equates with inner tube diameter, made by micropore inert hydrophobic material, the aperture is less than the blood cell component, can effectively intercept the visible component of blood, itself not can with blood in the reaction of any composition, can not adsorb any component in the blood yet.This material comprises the microporous filter membrane that the materials such as cellulose acetate, celluloid, mixed cellulose ester, nylon 6, nylon 66, Kynoar, politef, polyether sulfone, polypropylene are made.Preferred asymmetric polysulfone membrane, the dissymmetrical structure of film material can be caught the cellular component in the blood and cracking not occured, and can not form haemolysis, also can not adsorb critical biomarker.Should leave enough spaces between filter element top and the plug lower end, otherwise be difficult to adopt the blood of q.s.Also should leave sufficient space between at the bottom of filter element bottom and the blood taking tube pipe, otherwise the serum that filters can't hold.
This utility model is not directly isolated qualified serum by centrifuge after can realizing taking a blood sample by above design.
Make the blood taking tube body with borate glass, chlorinated scoline is made the plug of blood taking tube, high density polyethylene (HDPE) is made the blood taking tube inner tube, the buffer substrate tablet that inner tube is loaded successively asymmetric polysulfones filter membrane, polyethylene terephthalate fabric filter element and made by the lyophilizing coagulant, the inner pipe wall spraying contains the coagulant of thrombin, with the above-mentioned inner tube of the making blood taking tube body of packing into, plug is placed blood taking tube body top, put into tamponade after the vacuum machine preset vacuum.
Make the blood taking tube body with polyethylene terephthalate, chlorinated scoline is made the plug of blood taking tube, high density polyethylene (HDPE) is made the blood taking tube inner tube, the buffer substrate tablet that inner tube is loaded successively asymmetric polysulfones filter membrane, polyethylene terephthalate fabric filter element and made by the lyophilizing coagulant, the inner pipe wall spraying contains the coagulant of thrombin, with the above-mentioned inner tube of the making blood taking tube body of packing into, plug is placed blood taking tube body top, put into tamponade after the vacuum machine preset vacuum.
Make the blood taking tube body with poly ethyldiol modified polyethylene terephthalate, chlorinated scoline is made the plug of blood taking tube, high density polyethylene (HDPE) is made the blood taking tube inner tube, the buffer substrate tablet that inner tube is loaded successively asymmetric polysulfones filter membrane, polyethylene terephthalate fabric filter element and made by the lyophilizing coagulant, the inner pipe wall spraying contains the coagulant of thrombin, with the above-mentioned inner tube of the making blood taking tube body of packing into, plug is placed blood taking tube body top, put into tamponade after the vacuum machine preset vacuum.
Make the blood taking tube body with polyethylene terephthalate, brombutyl is made the plug of blood taking tube, polypropylene is made the blood taking tube inner tube, the buffer substrate tablet that inner tube is loaded successively asymmetric polysulfones filter membrane, polyethylene terephthalate fabric filter element and made by cephalin and kaolin, the inner pipe wall spraying contains the coagulant of thrombin, with the above-mentioned inner tube of the making blood taking tube body of packing into, plug is placed blood taking tube body top, put into tamponade after the vacuum machine preset vacuum.
Make the blood taking tube body with borate glass, brombutyl is made the plug of blood taking tube, high transparent polypropylene is made the blood taking tube inner tube, inner tube is loaded successively asymmetric polysulfones filter membrane, polyethylene terephthalate fabric filter element and is coated with the filter paper of coagulant, the inner pipe wall spraying contains the coagulant of thrombin, with the above-mentioned inner tube of the making blood taking tube body of packing into, plug is placed blood taking tube body top, put into tamponade after the vacuum machine preset vacuum.
Make the blood taking tube body with poly ethyldiol modified polyethylene terephthalate, halogenated butyl rubber is made the plug of blood taking tube, Low Density Polyethylene is made the blood taking tube inner tube, inner tube is loaded successively asymmetric polysulfones filter membrane, polyethylene terephthalate fabric filter element and is coated with the buffer substrate tablet that the dacron membrane of coagulant is made, the inner pipe wall spraying contains the coagulant of thrombin, with the above-mentioned inner tube of the making blood taking tube body of packing into, plug is placed blood taking tube body top, put into tamponade after the vacuum machine preset vacuum.
Make vacuum test tube by above-described embodiment respectively, use venipuncture needle puncture vein, respectively capacity blood sampling, the upright placement 15 minutes after the blood sampling transfers to rubber plug for vacutainer and inner tube to discard in the lump.Observe the serum of collecting in the blood taking tube body and be faint yellow, limpid, transparent.
Claims (4)
1. direct vacuum test tube of separation of serum, comprise the blood taking tube body, inner tube, plug, filter element, the top that it is characterized in that described blood taking tube body (1) is provided with plug (9), the structure of plug (9) is the plug shape, the center upper portion of plug structure is provided with semi-circular recesses, two ends, plug (9) left and right sides, bottom embed to connect blood taking tube bodys (1) and are connected with blood taking tube inner tube (6) in the blood taking tube body (1), be provided with serum flow export (10) in the middle of the bottom of blood taking tube inner tube (6), the bottom of serum flow export is serum collecting chamber (2), top at blood taking tube inner tube (6) serum flow export is provided with filter membrane (3), the top of filter membrane (3) is provided with filter element (4), also be provided with buffer substrate tablet (5) on the described filter element (4), consist of by the Blood Sampling Room (8) between filter element (4) top to blood taking tube inner tube (6) top in the blood taking tube inner tube (6) thus, on the inwall of blood taking tube inner tube (6), also be provided with one deck coagulant (7).
2. a kind of directly vacuum test tube of separation of serum as claimed in claim 1 is characterized in that described blood taking tube body (1) is by a kind of the making in glass, the macromolecular material.
3. a kind of directly vacuum test tube of separation of serum as claimed in claim 1 is characterized in that described filter element (4) top is provided with one deck buffer substrate tablet (5), also is provided with the coagulant of one deck coating on the buffer substrate tablet.
4. a kind of directly vacuum test tube of separation of serum as claimed in claim 1 is characterized in that described filter membrane (3) is microporous filter membrane.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220397683 CN202875351U (en) | 2012-08-10 | 2012-08-10 | Vacuum blood sampling tube capable of directly separating serum |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201220397683 CN202875351U (en) | 2012-08-10 | 2012-08-10 | Vacuum blood sampling tube capable of directly separating serum |
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| Publication Number | Publication Date |
|---|---|
| CN202875351U true CN202875351U (en) | 2013-04-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201220397683 Expired - Lifetime CN202875351U (en) | 2012-08-10 | 2012-08-10 | Vacuum blood sampling tube capable of directly separating serum |
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| CN (1) | CN202875351U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106361354A (en) * | 2016-08-31 | 2017-02-01 | 秦明 | Blood sampling test-tube |
| CN109157228A (en) * | 2018-06-26 | 2019-01-08 | 南京工业大学 | A kind of heparin tube of instant serum separation |
| CN113189354A (en) * | 2021-04-30 | 2021-07-30 | 重庆国际旅行卫生保健中心(重庆海关口岸门诊部) | Portable quick blood type is just stereotyped and is detected subassembly |
-
2012
- 2012-08-10 CN CN 201220397683 patent/CN202875351U/en not_active Expired - Lifetime
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106361354A (en) * | 2016-08-31 | 2017-02-01 | 秦明 | Blood sampling test-tube |
| CN106361354B (en) * | 2016-08-31 | 2019-05-17 | 秦明 | Blood sampling test tube |
| CN109157228A (en) * | 2018-06-26 | 2019-01-08 | 南京工业大学 | A kind of heparin tube of instant serum separation |
| CN113189354A (en) * | 2021-04-30 | 2021-07-30 | 重庆国际旅行卫生保健中心(重庆海关口岸门诊部) | Portable quick blood type is just stereotyped and is detected subassembly |
| CN113189354B (en) * | 2021-04-30 | 2023-09-19 | 重庆国际旅行卫生保健中心(重庆海关口岸门诊部) | Portable quick blood typing detection assembly |
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Legal Events
| Date | Code | Title | Description |
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| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160122 Address after: 201609 Shanghai City, Songjiang District Road No. 59 leaf Yexie town Patentee after: LINGEN PRECISION MEDICAL PRODUCTS (SHANGHAI) CO.,LTD. Address before: 201609 Shanghai City, Songjiang District Road No. 100 -3 Yexie town leaves Patentee before: SHANGHAI KEHUA DIAGNOSTIC MEDICAL PRODUCTS Co.,Ltd. |
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| CX01 | Expiry of patent term |
Granted publication date: 20130417 |
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| CX01 | Expiry of patent term |