CN203494051U - Percutaneous administration therapeutic instrument - Google Patents
Percutaneous administration therapeutic instrument Download PDFInfo
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- CN203494051U CN203494051U CN201320563780.1U CN201320563780U CN203494051U CN 203494051 U CN203494051 U CN 203494051U CN 201320563780 U CN201320563780 U CN 201320563780U CN 203494051 U CN203494051 U CN 203494051U
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Abstract
The utility model discloses a percutaneous administration therapeutic instrument which comprises a power supply circuit, an MCU, a man-machine interaction device, an electroporation/ electricion introduction circuit, an ultrasonic introduction circuit and two treatment electrodes, wherein an ultrasonic energy transducer is arranged in a first treatment electrode and/or a second treatment electrode, the signal output end of the ultrasonic introduction circuit is connected with the input end of the ultrasonic energy transducer, the ultrasonic introduction circuit comprises an ultrasonic vibration circuit and a modulation circuit, the signal output end of the modulation circuit is connected with the modulation signal input end of the ultrasonic vibration circuit, and the modulation circuit is used for modulating ultrasonic signals generated by the ultrasonic vibration circuit to obtain ultrasonic signals of various different frequencies. The percutaneous administration therapeutic instrument realizes electroporation/ electricion introduction administration treatment and ultrasonic introduction administration treatment simultaneously, rapidly and effectively introduces medicament into skin, and provides excellent treatment effects.
Description
Technical field
This utility model relates to a kind for the treatment of equipment via skin, relates in particular to a kind for the treatment of equipment via skin that electroporation/electron ion imports drug treatment and ultrasonic therapy function that has concurrently.
Background technology
Transdermal delivery system refers to after percutaneous drug delivery, and medicine transdermal enters blood circulation and the therapeutic modality of a therapeutical effect.Percutaneous dosing treatment has the distinct advantages that surmounts general medication, can destroy without " first pass effect " and the gastrointestinal of liver, and skin interbed also has storage effect.Make drug level curve mild, avoided " peak valley phenomenon ", is provided action time that can be scheduled to and longer, maintain and stablize lasting blood drug level, toxicity and untoward reaction are little, easy to use.Percutaneous dosing therapeutic equipment and method, with its unique advantage, become recent domestic medicine worker's study hotspot, and development rapidly.
Traditional percutaneous dosing dosage form has the agent of bath, lotion, liniment, tincture, oil preparation, ointment, plaster, paste, bath agent etc.; The modern percutaneous dosing dosage form that application macromolecular material grows up has membrane, gel, cataplasma, paster agent etc.Medicine enters human body by skin naturally osmotic, will be by the horny layer of skin surface, horny layer is by fine and close cellularity, drug molecule extremely difficulty sees through, it is generally acknowledged that only having the lipophilic molecules of micromolecule amount to pass horny layer by naturally osmotic stops and enter human body, but actual drug molecular species is various, complex structure, particularly protein-based, molecular weight is very large, therefore there is much physics, the supplementary means of chemistry, for promoting the percutaneous of drug molecule to absorb, for example: chemical enhancement, iontophoresis, electroporation, ultrasonic importing, optical pressure imports, thermotherapy.
In disclosed patent documentation, introduction has and adopts the medicine of above-mentioned or several technology to import instrument, as: the patent No. is that " ZL201120526790.9 ", name are called the patent of " iontophoresis transdermal delivery device ", and this device only includes iontophoresis function; Publication number is that " CN102397621A ", name are called the patent of " enclosed laser shock wave transdermal administration device ", adopts laser mode work; Publication number is that " CN1403173 ", name are called the patent of " electric perforating system for transdermal medication ", has adopted electroporation medicine introductory technique; Application number is that " CN200910303225.3 ", name are called the patent application of " a kind of method of ultrasound wave and electric field superposition target medicine penetration and instrument ", that this instrument has adopted is ultrasonic, electroporation, ion method carry out medicine importing, but the ultrasonic signal of an only corresponding frequency of ultrasonic transducer, its ultrasonic therapeutic effect is not good enough.
Following other non-patent literature is also introduced various traditional percutaneous dosing treatment technologies:
Bao Jiali, waits seapeak, and Li Hong drug percutaneous is controlled physical technique [J] Chinese Journal of Medical Instrumentation discharging, 2004,28 (5): 313-318;
Li Liangcheng, Zhang Yongshun, short development [J] the biomedical engineering magazine that oozes equipment of the red ultrasonic medicinal of Li Zhong, 2009,26 (1): 185-186;
Wang Fei, progress [J] the Inpharm research magazine of the short infiltration method use in conjunction of high Shen transdermal, 2007,34 (4): 285-285;
The Chinese primary health care of the progress of Yan Shi transdermal medicine for treating [J], 2009,23 (3): 82-82;
Yang Fangfang, Zhang Yongping promotes application general introduction [J] Guiyang College of Traditional Chinese Medicine journal of Drug Percutaneous Absorption physical method, 2006,28 (2): 41-41;
Zhang Xiaoyi, Zhang Zhongyuan ultrasound wave promotes plant amedica Transdermal absorption mechanism [J] external treatment with Chinese medicine magazine, 2002,11 (2): 5-5;
Zhou Pengju, Deng Shengqi, flies new development [J] Acta Pharmaceutica Sinica that target administration is studied, 2010,45 (3): 300-306 before Gong;
Zhang Guoliang, Shi Zongdao. the progress of low frequency ultrasound transdermal administration [J]. West China pharmaceutical journal, 2001,16 (5): 367-368;
Gong Xiufen. the non-linear research of acoustics [J] in medical ultrasonic. Proceedings in Physics, 1996,9(2): 286～296;
In the data of above-mentioned various documents, iontophoresis has had very long use historical, and cation penetrates skin at anode place, and anion penetrates skin at negative electrode place, and neutral particle also can penetrate skin under the effect of electric osmose.Electroporation method is on the basis of iontophoresis, adopts the pulse of high pressure to process skin, makes skin surface form temporary transient hydrophilic duct, helps to make medicine enter more smoothly skin.Ultrasonic importing is also the nearlyer new technique for transdermal administration, the comprehensive functions such as hyperacoustic cavitation and non-cavitation, convection current transportation, deep-heating effect have been utilized, ultrasound wave imports owing to not being subject to drug molecule polarity effect, and medicine adaptability is better than iontophoresis.
But adopt single means, for example: adopt merely electroporation, iontophoresis, thermotherapy, ultrasonicly have its limitation, cannot make medicine see through fast and effectively, particularly Chinese medicine, because complicated component, its effective ingredient may comprise different types of drug molecule.Adopt multiple means synergism, than adopting single lead-in mode more can increase work efficiency, strengthen effect, particularly ultrasound wave that medicine imports, can significantly strengthen transdermal penetration amount.
When supersonic medicine imports, frequency is a most important parameter, high frequency ultrasound (more than 800Khz) and low frequency ultrasound (100Khz is following) demonstrate different effects, and the medicine that each self adaptation is dissimilar, therefore adopts the ultrasonic importing of single-frequency to have its inborn defect.Address this problem, just need equipment can produce high frequency ultrasound and also can produce low frequency ultrasound.Yet ultrasonic transducer has a fixing resonant frequency, can not be operated in low frequency and be operated in again high frequency, it is all to adopt single frequency that therefore existing ultrasonic medicinal imports.Seen the equipment of the ultrasonic importing of employing of mentioning in open source information, all to adopt single-frequency ultrasonic, adopt high frequency ultrasound (more than 800Khz), adopt low frequency ultrasound (100Khz is following), but the ultrasound wave of different frequency for different medicines, mechanism is different, so single-frequency is ultrasonic can not well adapt to various kinds of drug.
The people's such as Schoellhammer in 2012 a research, mentioned the importing experiment of a double-frequency ultrasound, having shown that double frequency is worked simultaneously can reach better effect, this experiment adopts the ultrasound wave of two frequencies of height to import (a 1Mhz simultaneously, a 20Khz), result shows that mechanism can reach the several times of single-frequency, experimental result prompting double-frequency ultrasound has reached the effect that 1+1 is greater than 2, as shown in Figure 1, Curves is shown the mechanism of inulin under double-frequency ultrasound above, below Curves be shown the mechanism of inulin under single-frequency is ultrasonic; As shown in Figure 2, above Curves be shown the mechanism of glucose under double-frequency ultrasound, below Curves be shown the mechanism of glucose under single-frequency is ultrasonic.But this research adopts two ultrasonic transducers to work simultaneously, although reached reasonable effect, uses two transducer architecture complexity simultaneously, bulky, does not possess engineering practicability, cannot be for clinical treatment.
When carrying out medicine importing, because ingredient is complicated, molecule is similar various, molecular size range differs, architectural difference is large, for different medicines, need to find out by experiment corresponding, different treatment parameter combinations, comprise electroporation, the waveform that electric conductance enters, frequency, dutycycle, the combination of the parameters such as ultrasonic, these all need to be tested and determine for different medicines, therefore need the treatment parameter combinations of the necessary various medicines of built-in correspondence of instrument, if all medicines only adopt a kind of fixing parameter to import, understand some medicines and import very poor of effect.
Utility model content
The purpose of this utility model provides a kind for the treatment of equipment via skin that electroporation/electron ion imports treatment and ultrasonic importing treatment function that has concurrently with regard to being in order to address the above problem.
In order to achieve the above object, this utility model has adopted following technical scheme:
Treatment equipment via skin described in the utility model comprises power circuit, MCU main control module, human-computer interaction device, electroporation/electron ion imports circuit, ultrasonic importing circuit, the first therapeutic electrode and the second therapeutic electrode, the control output end of described MCU main control module is connected with the control input end of described ultrasonic importing circuit with the control input end of described electroporation/electron ion importing circuit respectively, in described the first therapeutic electrode and/or described the second therapeutic electrode, comprise ultrasonic transducer, the signal output part that described electroporation/electron ion imports circuit is connected with described the second therapeutic electrode with described the first therapeutic electrode respectively, the signal output part of described ultrasonic importing circuit is connected with the input of described ultrasonic transducer, described ultrasonic importing circuit comprises sonic oscillation circuit and modulation circuit, the signal output part of described modulation circuit is connected with the modulation signal input of described sonic oscillation circuit, and described modulation circuit modulates to obtain the ultrasonic signal of a plurality of different frequencies for the ultrasonic signal that described sonic oscillation circuit is produced.
Adopt modulation circuit to modulate after (being specially amplitude modulation, frequency modulation and/or phase modulation) ultrasonic signal, the ultrasonic signal that the ultrasonic signal of sonic oscillation circuit output is a plurality of different frequencies only increases the object that a modulation circuit realizes a plurality of frequency ultrasonic signal outputs on the basis of a ultrasonator and a ultrasonic transducer.
Particularly, described electroporation/electron ion imports circuit and comprises high-voltage amplifier and controlled current source loads, in described MCU main control module, be provided with a DAC circuit and the 2nd DAC circuit, a described signal output part for DAC circuit and the signal input part of described high-voltage amplifier are connected, described the 2nd signal output part of DAC circuit and one end of described controlled current source loads are connected, and the signal output part of described high-voltage amplifier is connected with described the second therapeutic electrode with described the first therapeutic electrode respectively with the other end of described controlled current source loads.The waveform that can output waveform can change arbitrarily by DAC circuit imports treatment for electroporation/electron ion.
Further, be also provided with the first adc circuit and the second adc circuit in described MCU main control module, the signal input part of described the first adc circuit is connected with described high-voltage amplifier, and the signal input part of described the second adc circuit is connected with described controlled current source loads.
As preferably, in described the first therapeutic electrode and described the second therapeutic electrode, all comprise ultrasonic transducer, described sonic oscillation circuit comprises the first sonic oscillation circuit and the second sonic oscillation circuit, and described modulation circuit comprises the first modulation circuit and the second modulation circuit.
Further, described treatment equipment via skin also comprises the rfid circuit for detection of the radio-frequency (RF) tag information in drug packaging, and the outfan of described rfid circuit connects with the corresponding I/O end of described MCU main control module.
The beneficial effects of the utility model are:
By this utility model, can realize simultaneously patient is carried out to electroporation/electron ion importing drug treatment and ultrasound wave importing drug treatment, make medicine fast and effeciently import skin, realize better therapeutic effect.Imbody is in the following areas:
1, can produce by the DAC circuit of MCU main control module electroporation/electron ion importing signal of telecommunication of random waveform, by MCU main control module, can change ultrasonic dutycycle, and the combination of multiple import plan, allow operator to choose prefabricated appointment import plan according to different medicines, to adapt to different medicines, thereby improve the efficiency that medicine imports;
2, adopt by the hyperacoustic structure of modulating circuit modulates, only use single ultrasonic transducer (being ultrasonic vibrator) to realize the function of multiple frequency ultrasonic, take up room little, be convenient to application, because modulating frequency can change within the scope of one, and modulation signal is to be produced by main control module, changeable frequency, so this therapeutic instrument can be exported the ultrasound wave of multifrequency and frequency conversion.
3, pass through rfid circuit, can further realize automatic adaptation: by RF identification, read the RFID label information in medicine packing, obtain after drug information the parameters that Automatically invoked adapts, reduce the workload of user, reduced maloperation probability.
Accompanying drawing explanation
Fig. 1 is the medicine mechanism schematic diagram of the ultrasonic and double-frequency ultrasound of the single-frequency of inulin;
Fig. 2 is the medicine mechanism schematic diagram of the ultrasonic and double-frequency ultrasound of the single-frequency of glucose;
Fig. 3 is the circuit block diagram for the treatment of equipment via skin described in the utility model.
The specific embodiment
Below in conjunction with accompanying drawing, this utility model is further described in detail:
As shown in Figure 3, treatment equipment via skin described in the utility model comprises power circuit, MCU main control module, human-computer interaction device, the first therapeutic electrode, the second therapeutic electrode, high-voltage amplifier, controlled current source loads, the first modulation circuit, the second modulation circuit, the first sonic oscillation circuit, the second sonic oscillation circuit and rfid circuit, MCU main control module is provided with two-way DAC and two-way ADC, two-way DAC i.e. a DAC circuit (i.e. DAC1 in figure) and the 2nd DAC circuit (i.e. DAC2 in figure), two-way ADC i.e. the first adc circuit (i.e. ADC1 in figure) and the second adc circuit (i.e. ADC2 in figure), the one signal output part of DAC circuit and the signal input part of high-voltage amplifier are connected, the 2nd DAC circuit signal outfan is connected with one end of controlled current source loads, the signal input part of the first adc circuit is connected with high-voltage amplifier, the signal input part of the second adc circuit is connected with controlled current source loads, the signal output part of high-voltage amplifier is connected with the second therapeutic electrode with the first therapeutic electrode respectively with the other end of controlled current source loads, the first therapeutic electrode and the second therapeutic electrode all comprise ultrasonic transducer, two ultrasonic control output ends of MCU main control module are connected with the control end of the second sonic oscillation circuit with the control end of the first sonic oscillation circuit respectively, and the ultrasonic signal outfan of the ultrasonic signal outfan of the first sonic oscillation circuit and the second sonic oscillation circuit is connected with the input of the ultrasonic transducer of the second therapeutic electrode with the input of the ultrasonic transducer of the first therapeutic electrode respectively, two modulation signal outfans of MCU main control module are connected with the input of the second modulation circuit with the input of the first modulation circuit respectively, and the outfan of the outfan of the first modulation circuit and the second modulation circuit is connected with the modulation input of the second sonic oscillation circuit with the modulation input of the first sonic oscillation circuit respectively, rfid circuit is for detection of the radio-frequency (RF) tag information in drug packaging, and the outfan of rfid circuit connects with the corresponding I/O end end of MCU main control module.
In Fig. 3, also show power circuit, power circuit is comprised of attaching plug, overcurrent protective device, transformator, current rectifying and wave filtering circuit, high tension generator.At electroporation with electro-ionic time, required ceiling voltage is different, when electroporation, the highest need to about 200V voltage, iontophoresis is generally tens V voltages, so in power circuit, comprises a controlled high tension generator, can control its output 50V or 200V voltage.Power circuit is also responsible for providing the required 5V of control section and 3.3V power supply, also exports in addition 50V DC voltage for ultrasonic part.The structure of above-mentioned power circuit is conventional structure.
In addition, MCU main control module, high-voltage amplifier, controlled current source loads and human-computer interaction device are all conventional electronic units, wherein, MCU main control module is the control section of complete machine, MCU, reset circuit, two-way DAC, two-way ADC, consist of, DAC imports the required signal of telecommunication for generation of electroporation and electron ion, and ADC changes for real-time human body Skin Resistance, measurement result can, for assessment of short effect of oozing, can supply doctor as the reference for the treatment of; Measurement result can be for doctor as the reference for the treatment of; High-voltage amplifier and controlled current source loads form electroporation and electro-ionic critical piece jointly.Human body skin by therapeutic electrode and controlled constant current source-series after, as the load of high-voltage amplifier.Human-computer interaction device by LED or LCD as demonstration, with button (physical button or touch key-press) input of control commands.
As shown in Figure 3, during use, the first therapeutic electrode and the second therapeutic electrode directly act on patient skin, and the drug treatment method of whole treatment equipment via skin is as follows:
Before treatment, be first determined by experiment the treatment parameter combinations of various kinds of drug the best, the prefabricated multiple therapeutic scheme for different pharmaceutical is also stored in MCU main control module.
During treatment, by rfid circuit, read the radio-frequency (RF) tag information (being RFID information) on identification treatment tablet package, MCU main control module can be according to the drug data reading and prefabricated therapeutic scheme, and configuration meets electroporation, electron ion and the ultrasonic running parameter of this kind of medicine voluntarily.Operator also can manual configuration.
When electroporation imports treatment, MCU master control module controls power circuit output 200V high pressure, power supply as high-voltage amplifier, required electroporation waveform, two-way DAC in MCU main control module exports, the one DAC circuit amplifies through high-voltage amplifier, become 100～200V high-voltage pulse, through the first therapeutic electrode and the second therapeutic electrode, enter in patient skin, because its electric current is subject to the restriction of controlled current source loads, so can avoid excessive electric current to damage patient, controlled current source loads is set by the 2nd DAC circuit in MCU main control module, both can export fixed level, also can export prefabricated waveform.
When electron ion imports treatment, MCU master control module controls power circuit output 50V, as the power supply of high-voltage amplifier, operation principle is identical with electroporation, but its running voltage, waveform, electric current all arrange difference.
During ultrasonic importing treatment, by MCU main control module, produce the ultrasonic control signal of two-way and send to respectively the first sonic oscillation circuit and the second sonic oscillation circuit, make it produce respectively ultrasonic signal, simultaneously, by MCU main control module, produce two-way low frequency signal as modulating frequency, pass through respectively the first modulation circuit and the second modulating circuit modulates to two-way ultrasonic signal.Carrying wave frequency is determined by the resonant frequency of the ultrasonic transducer in therapeutic electrode itself.For the ultrasonic transducer of 1Mhz, the general value of modulating frequency is tens of Khz, and this is because the limited bandwidth of ultrasonic transducer.Ultrasonic signal corresponding to above-mentioned each therapeutic electrode comprises the ultrasonic signal of three different frequencies, the ultrasonic signal of a plurality of different frequencies obtains in the following manner: the power supply of the low frequency signal that Yong Yi road frequency is f2 (being produced by MCU main control module) Modulated Ultrasonic oscillating circuit, the resonant frequency of this sonic oscillation circuit is f1, it is high frequency, the envelope of the ultrasonic signal of ultrasonic transducer output is low frequency signal, thereby obtains the ultrasonic signal that three frequencies are respectively f1, f1+f2, f1-f2.
What the ultrasonic transducer in therapeutic electrode was launched is the signal after modulation, three frequencies are respectively the ultrasonic signal of f1, f1+f2, f1-f2, ultrasound wave is propagated in tissue, tissue is nonlinear dielectric for ultrasound wave, due to nonlinear effect, can produce a series of frequency multiplication, difference frequency and frequency, thereby by f2 demodulation out, in new spectrum component, comprise f2 component, realized high frequency, low frequency is worked simultaneously, realize an electrode and only used a ultrasonic transducer, carried out high and low frequency importing simultaneously.
In said process, also by the adc circuit in MCU main control module, measure in real time skin voltage, through calculating Skin Resistance, by the impedance of record, demonstration skin, for the short effect of oozing of user assessment.
Claims (5)
1. a treatment equipment via skin, comprise power circuit, MCU main control module, human-computer interaction device, electroporation/electron ion imports circuit, ultrasonic importing circuit, the first therapeutic electrode and the second therapeutic electrode, the control output end of described MCU main control module is connected with the control input end of described ultrasonic importing circuit with the control input end of described electroporation/electron ion importing circuit respectively, in described the first therapeutic electrode and/or described the second therapeutic electrode, comprise ultrasonic transducer, the signal output part that described electroporation/electron ion imports circuit is connected with described the second therapeutic electrode with described the first therapeutic electrode respectively, the signal output part of described ultrasonic importing circuit is connected with the input of described ultrasonic transducer, it is characterized in that: described ultrasonic importing circuit comprises sonic oscillation circuit and modulation circuit, the signal output part of described modulation circuit is connected with the modulation signal input of described sonic oscillation circuit, and described modulation circuit modulates to obtain the ultrasonic signal of a plurality of different frequencies for the ultrasonic signal that described sonic oscillation circuit is produced.
2. treatment equipment via skin according to claim 1, it is characterized in that: described electroporation/electron ion imports circuit and comprises high-voltage amplifier and controlled current source loads, in described MCU main control module, be provided with a DAC circuit and the 2nd DAC circuit, a described signal output part for DAC circuit and the signal input part of described high-voltage amplifier are connected, described the 2nd signal output part of DAC circuit and one end of described controlled current source loads are connected, the signal output part of described high-voltage amplifier is connected with described the second therapeutic electrode with described the first therapeutic electrode respectively with the other end of described controlled current source loads.
3. treatment equipment via skin according to claim 2, it is characterized in that: in described MCU main control module, be also provided with the first adc circuit and the second adc circuit, the signal input part of described the first adc circuit is connected with described high-voltage amplifier, and the signal input part of described the second adc circuit is connected with described controlled current source loads.
4. treatment equipment via skin according to claim 1, it is characterized in that: in described the first therapeutic electrode and described the second therapeutic electrode, all comprise ultrasonic transducer, described sonic oscillation circuit comprises the first sonic oscillation circuit and the second sonic oscillation circuit, and described modulation circuit comprises the first modulation circuit and the second modulation circuit.
5. according to the treatment equipment via skin described in claim 1,2 or 3, it is characterized in that: described treatment equipment via skin also comprises the rfid circuit for detection of the radio-frequency (RF) tag information in drug packaging, the outfan of described rfid circuit connects with the corresponding I/O end of described MCU main control module.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320563780.1U CN203494051U (en) | 2013-09-11 | 2013-09-11 | Percutaneous administration therapeutic instrument |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320563780.1U CN203494051U (en) | 2013-09-11 | 2013-09-11 | Percutaneous administration therapeutic instrument |
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| CN203494051U true CN203494051U (en) | 2014-03-26 |
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| CN201320563780.1U Withdrawn - After Issue CN203494051U (en) | 2013-09-11 | 2013-09-11 | Percutaneous administration therapeutic instrument |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446668A (en) * | 2013-09-11 | 2013-12-18 | 成都锐联科技有限公司 | Transdermal drug delivery therapeutic apparatus and transdermal drug delivery therapeutic method |
| CN107185107A (en) * | 2017-05-13 | 2017-09-22 | 沈阳赛镝医疗器械有限公司 | A kind of ultrasonic direct current current iontophoresis system |
| US11857459B2 (en) | 2016-05-18 | 2024-01-02 | Sonikure Holdings Limited | System and method for ultrasound-enhanced delivery of drugs |
-
2013
- 2013-09-11 CN CN201320563780.1U patent/CN203494051U/en not_active Withdrawn - After Issue
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446668A (en) * | 2013-09-11 | 2013-12-18 | 成都锐联科技有限公司 | Transdermal drug delivery therapeutic apparatus and transdermal drug delivery therapeutic method |
| CN103446668B (en) * | 2013-09-11 | 2015-09-09 | 曾郑刚 | A kind for the treatment of equipment via skin and percutaneous dosing Therapeutic Method |
| US11857459B2 (en) | 2016-05-18 | 2024-01-02 | Sonikure Holdings Limited | System and method for ultrasound-enhanced delivery of drugs |
| CN107185107A (en) * | 2017-05-13 | 2017-09-22 | 沈阳赛镝医疗器械有限公司 | A kind of ultrasonic direct current current iontophoresis system |
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Owner name: CENG ZHENGGANG Free format text: FORMER OWNER: CHENGDU RUSHUNITE SCIENCE + TECHNOLOGY CO., LTD. Effective date: 20141017 |
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Effective date of registration: 20141017 Address after: 610000 No. 1, No. 3, building 45, 6 Xiaojiahe street, Chengdu hi tech Zone, Sichuan, China Patentee after: Zeng Zhenggang Address before: 610000 Sichuan city of Chengdu province high tech Zone Guixi Industrial Park Patentee before: Chengdu Rushunite Technology Co., Ltd. |
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