CN204017139U - A kind of ultrasonic and infrared compound transdermal delivery device - Google Patents
A kind of ultrasonic and infrared compound transdermal delivery device Download PDFInfo
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- CN204017139U CN204017139U CN201420411417.2U CN201420411417U CN204017139U CN 204017139 U CN204017139 U CN 204017139U CN 201420411417 U CN201420411417 U CN 201420411417U CN 204017139 U CN204017139 U CN 204017139U
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- transdermal delivery
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Abstract
A kind of ultrasonic and infrared compound transdermal delivery device, comprise two ends all in trumpet-shaped external shell, the inside of housing is provided with ultrasonic transdermal delivery system and infrared transdermal delivery system, described infrared transdermal delivery system comprise for generation of with transmitting ultrared infrared ray radiation unit and the modulator for controlling infrared ray radiation unit, described ultrasonic transdermal delivery system comprises supersonic sounding unit, ultrasonic irradiation unit and the ultrasound control unit for controlling supersonic sounding unit and ultrasonic irradiation unit, the spongy layer for adsorbing medicine is also provided with outside housing lower surface.This utility model overcomes that existing transdermal delivery device injection speed is slow, administering effect is poor, administration time and the technical problem such as skin attachement is not tight, accelerate the absorption rate of skin to medicine, improve the permeability of macromolecular drug.
Description
Technical field
This utility model relates to a kind of transdermal delivery device, and the composite construction of specifically a kind of ultrasound wave vibration and infrared ray radiation makes the organic transdermal delivery device of drug percutaneous permeation parts.
Background technology
Transdermal delivery system refers to after percutaneous drug delivery, medicine transdermal, enters the therapeutic modality of blood circulation and a therapeutical effect.Percutaneous dosing treatment has the particular advantages surmounting general medication, can destroy without " first pass effect " of liver and gastrointestinal, and skin interbed also has storage effect, makes drug concentration profile mild, avoid " peak valley phenomenon ", maintain and stablize lasting haemoconcentration.Percutaneous dosing therapeutic equipment and method, with the advantage of its uniqueness, become the study hotspot of recent domestic medical personal, and development rapidly.
Transdermal delivery device in present society has a lot, but exist corresponding not enough all separately, reason is exactly that the means adopted are single, as: the patent No. is " ZL201120526790.9 ", name is called the patent of " iontophoresis transdermal delivery device ", and this device only includes iontophoresis function; Publication number is " CN102397621A ", name is called the patent of " enclosed laser shock wave transdermal administration device ", adopts laser mode work; Publication number is " CN1403173 ", name is called the patent of " electric perforating system for transdermal medication ", have employed electroporation drugs delivery method; Application number is " CN200910303225.3 ", name is called that " a kind of method of ultrasound wave and electric field superposition target medicine penetration and instrument, above-mentioned instrument is all have employed single ultrasonic, electroporation, ion method to carry out drugs delivery, and therapeutic effect is not good.Cannot make medicine fast and effeciently carry out through, particularly Chinese medicine, because complicated component, its effective ingredient may comprise different types of drug molecule.
Composite drug administration is detected in a kind of physics and a kind of chemical enhancement methods combining, rare two kinds of physics administering mode compounds.About the synergistic bibliographical information of iontophoresis and other short saturating methods is less.
Utility model content
In order to overcome, existing transdermal delivery device injection speed is slow, administering effect is poor, administration time and the technical problem such as skin attachement is not tight, this utility model provides one can accelerate skin to drug absorption rate, improves the New Percutaneous doser of macromolecular drug permeability.
This utility model is for solving the problems of the technologies described above, and the technical scheme adopted is: this utility model is divided into two parts, is ultrasonic transdermal delivery system and infrared transdermal delivery system respectively.Be provided with a housing, this housing is upper and lower symmetrical structure, and upper and lower two ends are all in horn-like, the inside of housing is provided with ultrasonic transdermal delivery system and infrared transdermal delivery system, described infrared transdermal delivery system comprise for generation of with transmitting ultrared infrared ray radiation unit and the modulator for controlling infrared ray radiation unit, described ultrasonic transdermal delivery system comprises supersonic sounding unit, ultrasonic irradiation unit and the ultrasound control unit for controlling supersonic sounding unit and ultrasonic irradiation unit, described supersonic sounding unit, ultrasonic irradiation unit and infrared ray radiation unit are all arranged near the lower surface of housing, and infrared ray radiation unit is in the loop configuration matched with hull outside circumference, supersonic sounding unit and ultrasonic irradiation unit are arranged on the inner side of loop configuration infrared ray radiation unit, outside described housing lower surface, below corresponding to supersonic sounding unit and ultrasonic irradiation unit is also provided with one for adsorbing the spongy layer of medicine.The thickness of spongy layer is 0.5-2cm.
The lower surface of described housing is in the arc caved in the inside, and radian is 2-2.7.
The lower surface of described housing is elastic material.
Beneficial effect:
1, ultrasonic and infrared compound transdermal delivery device of the present utility model arranges ultrasonic transdermal delivery system and infrared transdermal delivery system respectively in device, during use, first the intercellular lipid of keratodermatitis is impelled to relax by ultrasonic transdermal delivery system, the drugs delivery adsorbed by spongy layer is in organism, cutaneous circulation is accelerated again by infrared transdermal delivery system, increase the permeability of skin, make macromolecular medicine smoothly, rapidly through tissue, enter darker position, the absorption efficiency of medicine and speed are multiplied; Two systems synergism functionally significantly improves operational efficiency and the administering effect of percutaneous dosing, make drug effect more effectively with lasting, the dermopathic generations such as the such as skin burn that traditional chemical penetrating agent can also be avoided to cause, finally make safety of medicine effectively through body, more efficiently absorbed by body.
2, the lower surface of this utility model housing is configured to arc, and the material of lower surface is the elastomeric material that silica gel, rubber etc. have deformability, when with contact human skin, can according to concrete skin texture situation, conversion radian and shape, to make device and skin attachement tightr, enhance motility and the administering effect of device, be suitable for effective.
3, apparatus structure of the present utility model is simple, easy to operate, is convenient to control, and the horn-like structure of two ends symmetry makes to constitute one in the middle part of device and facilitates hand-held arc surface, also effectively increases the active area of device simultaneously.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Fig. 2 is structural representation upward view of the present utility model;
Fig. 3 is the ultrasonic transmit circuit figure in this utility model;
Reference numeral: 1, modulator; 2, ultrasound control unit; 3, supersonic sounding unit; 4, infrared ray radiation unit; 5, ultrasonic irradiation unit; 6, spongy layer; 7, housing, 8, resistance, 9, electric capacity, 10, slide rheostat, 11, reverser, 12, reverser, 13, reverser, 14, reverser, 15, switch, 16, electric capacity, 17, electric capacity, 18, transducer.
Detailed description of the invention
Below in conjunction with accompanying drawing, detailed description of the invention of the present utility model is described:
A kind of ultrasonic and infrared compound transdermal delivery device, be provided with a housing 7, this housing 7 is upper and lower symmetrical structure, and upper and lower two ends are all in horn-like, the inside of housing 7 is provided with ultrasonic transdermal delivery system and infrared transdermal delivery system, described infrared transdermal delivery system comprises for generation of and launches ultrared infrared ray radiation unit 4 and the modulator 1 for controlling infrared ray radiation unit 4, described ultrasonic transdermal delivery system comprises supersonic sounding unit 3, ultrasonic irradiation unit 5 and the ultrasound control unit 2 for controlling supersonic sounding unit 3 and ultrasonic irradiation unit 5, described supersonic sounding unit 3, ultrasonic irradiation unit 5 and the medial surface of infrared ray radiation unit 4 all near the lower surface of housing 7 are arranged, and infrared ray radiation unit 4 is in the loop configuration matched with housing 7 inside circumference, supersonic sounding unit 3 and ultrasonic irradiation unit 5 are arranged on the inner side of loop configuration infrared ray radiation unit 4, outside described housing 7 lower surface, below corresponding to supersonic sounding unit 3 and ultrasonic irradiation unit 5 is also provided with one for adsorbing the spongy layer 6 of medicine.The thickness of spongy layer 6 is 0.5-2cm.The lower surface of described housing 7 is in the arc caved in the inside, and radian is 2-2.7, and the material of described housing 7 lower surface is the elastomeric material that silica gel, rubber etc. have deformability.
Device of the present utility model is when specifically using, supersonic sounding unit 3 utilizes the diagnostic feature of ultrasound wave, when applying ultrasound wave to organism, this supersonic sounding unit 3 receives the ultrasound wave from organism reflection, to measure and to check the degree of depth through position required for medicine, the testing result of supersonic sounding unit 3 is sent to ultrasound control unit 2, to determine hyperacoustic illuminate condition that the degree of depth detected with supersonic sounding unit 3 is applicable to.Then, based on the illuminate condition that ultrasound control unit 2 is determined, control to send ultrasonic irradiation from ultrasonic transducer in ultrasonic irradiation unit 5.In addition, ultrasound control unit 2 has the circuit controlling the hyperacoustic illuminate condition applied from the ultrasonic converter ultrasonic irradiation unit 5, ultrasound control unit 2 controls to comprise the ultrasonic irradiation conditions such as frequency, irradiation power, Switching Power Supply, irradiation time, and illuminate condition can be carried out automatically and manually by the control operation of ultrasound control unit 2.
In ultrasonic transmit circuit in the drawings, reverser 11, three gate oscillators that reverser 12 and reverser 13 form are square wave in the output at reverser 13 place, and its operating frequency determines primarily of electric capacity 9, resistance 8 and slide rheostat 10, and regulates concrete frequency by slide rheostat 10.One end of the output drive transducer 18 of reverser 13 and reverser 14, the other end of the output drive transducer 18 of reverser 14, therefore, adds reverser 14 and driving voltage is doubled.Wherein, in circuit, the model of reverser 14 is T40-16; Reverser 11, reverser 12, reverser 13 and reverser 14 all adopt CC4069 six reverser; The voltage of power supply is 9V.
Infrared ray radiation unit 4 in infrared transdermal delivery system for generation of with transmitting infrared ray, modulator 1 is for controlling the optimum configurations such as switch, power, wavelength of infrared ray radiation unit 4.
The Infrared wavelength that this infrared ray radiation unit 4 is applied to skin surface should be not less than 2um and not higher than 20um, further preferred words, should apply the infrared ray that wavelength is 6um ~ 10um, the peptide bond of infra-red radiation more easily and in peptide and protein because of wave band for this reason produces and resonates.The irradiation power of infrared radiation unit should maintain 0.8w/cm
2.
The ultrasonic frequency that ultrasound control unit 2 controls ultrasonic irradiation unit 5 transmitting should be not less than 0.5MHz, concrete words should maintain 2MHz ~ 7MHz, the generation of the skin disorder that the ultrasound wave of this band frequency may avoid such as skin surface to burn, and finally make safety of medicine effectively through organism.
Adopting multiple means collaborative work, than adopting single lead-in mode more can increase work efficiency, strengthening the importing effect of medicine, particularly ultrasonic, can significantly strengthen transdermal penetration amount.Can not human body skin be well allowed to absorb expeditiously medicine to overcome existing transdermal delivery device, this utility model provides a kind of new transdermal delivery device, this device adopts ultrasound wave and infrared ray compound, ultrasonic energy makes the intercellular lipid of keratodermatitis relax, the absorbance of medicine can be improved so greatly, and also apply to infrared ray in device, infrared ray can accelerate cutaneous circulation, increase the permeability of skin, allow medicine be absorbed expeditiously, at utmost and full out allow absorption of human body to skin medicine.
Medicine enters human body by skin naturally osmotic, will by the horny layer of skin surface, horny layer by the cellularity of densification, drug molecule extremely difficult through, it is generally acknowledged that only having the lipophilic molecules energy naturally osmotic of small-molecular-weight to stop through horny layer enters human body, but actual drug molecular species is various, complex structure, particularly protein-based, molecular weight is large especially, so these molecules are difficult to be absorbed, cause a lot of medicine to be wasted, even do not reach the effect for the treatment of.And this device have employed the technology of ultrasonic and infrared compound, ultrasonic wave energy makes the intercellular lipid of keratodermatitis relax, make medicine effectively through expect through position.Infrared ray can excite the resonance of amido link in polypeptide drugs peptide bond and hydroxyl, to the polypeptide even activation of protein drug diffusion generation highly significant, in addition, infrared ray also can be that amido link in its human body skin protein and hydroxyl produce resonance, make skin pore and horny layer expansion, and the intercellular lipid of keratodermatitis is relaxed, activating human body skin, improves drug penetration.Therefore, this device makes the existing doser of agent permeates therethrough Performance Ratio exceed several times.
Technical scheme cited by this utility model and embodiment are not restrictions, to be equal to embodiment with the technical scheme cited by this utility model or scheme that effect is identical all in the scope that this utility model is protected.
Claims (4)
1. a ultrasonic and infrared compound transdermal delivery device, be provided with a housing (7), it is characterized in that: this housing (7) is upper and lower symmetrical structure, and upper and lower two ends are all in horn-like, the inside of housing (7) is provided with ultrasonic transdermal delivery system and infrared transdermal delivery system, described infrared transdermal delivery system comprises for generation of and launches ultrared infrared ray radiation unit (4) and the modulator (1) for controlling infrared ray radiation unit (4), described ultrasonic transdermal delivery system comprises supersonic sounding unit (3), ultrasonic irradiation unit (5) and the ultrasound control unit (2) for controlling supersonic sounding unit (3) and ultrasonic irradiation unit (5), described supersonic sounding unit (3), ultrasonic irradiation unit (5) and infrared ray radiation unit (4) are all attached on the medial surface of housing (7) lower surface, and infrared ray radiation unit (4) is in the loop configuration matched with housing (7) inside circumference, supersonic sounding unit (3) and ultrasonic irradiation unit (5) are arranged on the inner side of loop configuration, outside described housing (7) lower surface, below corresponding to supersonic sounding unit (3) and ultrasonic irradiation unit (5) is also provided with one for adsorbing the spongy layer (6) of medicine.
2. the ultrasonic and infrared compound transdermal delivery device of one according to claim 1, is characterized in that: the thickness of described spongy layer (6) is 0.5-2cm.
3. the ultrasonic and infrared compound transdermal delivery device of one according to claim 1, is characterized in that: the lower surface of described housing (7) is in the arc caved in the inside, and radian is 2-2.7.
4. the ultrasonic and infrared compound transdermal delivery device of one according to claim 3, is characterized in that: the lower surface of described housing (7) is elastic material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420411417.2U CN204017139U (en) | 2014-07-24 | 2014-07-24 | A kind of ultrasonic and infrared compound transdermal delivery device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201420411417.2U CN204017139U (en) | 2014-07-24 | 2014-07-24 | A kind of ultrasonic and infrared compound transdermal delivery device |
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| Publication Number | Publication Date |
|---|---|
| CN204017139U true CN204017139U (en) | 2014-12-17 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201420411417.2U Expired - Fee Related CN204017139U (en) | 2014-07-24 | 2014-07-24 | A kind of ultrasonic and infrared compound transdermal delivery device |
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| Country | Link |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104117139A (en) * | 2014-07-24 | 2014-10-29 | 河南科技大学 | Ultrasound and infrared combined transdermal drug delivery device |
| CN110193138A (en) * | 2019-06-14 | 2019-09-03 | 翁作森 | Drug penetration through skin device |
-
2014
- 2014-07-24 CN CN201420411417.2U patent/CN204017139U/en not_active Expired - Fee Related
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104117139A (en) * | 2014-07-24 | 2014-10-29 | 河南科技大学 | Ultrasound and infrared combined transdermal drug delivery device |
| CN110193138A (en) * | 2019-06-14 | 2019-09-03 | 翁作森 | Drug penetration through skin device |
| CN110193138B (en) * | 2019-06-14 | 2023-12-26 | 湖南铭仁控股集团有限公司 | Drug skin permeation device |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20141217 Termination date: 20170724 |