CN111467666A - Ultrasonic medicine feeding device - Google Patents
Ultrasonic medicine feeding device Download PDFInfo
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- CN111467666A CN111467666A CN202010203307.7A CN202010203307A CN111467666A CN 111467666 A CN111467666 A CN 111467666A CN 202010203307 A CN202010203307 A CN 202010203307A CN 111467666 A CN111467666 A CN 111467666A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
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- Heart & Thoracic Surgery (AREA)
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Abstract
The invention relates to the technical field of medical instruments, and relates to an ultrasonic drug delivery device, which comprises: the main probe comprises an electrode plate, a rubberizing, an ultrasonic transducer, a patch carrier and a medicine containing patch; the electrode plate is arranged in the main probe shell and is bonded with the ultrasonic transducer through the adhesive tape; one surface of the patch carrier is fixed on the electrode sheet and keeps good contact with the surface of the electrode sheet around the electrode sheet, the other surface of the patch carrier is attached with the medicine containing patch which can be immersed in medicine liquid, and the electrode sheet and the electric wire of the ultrasonic transducer are led out through signal wires and connected with treatment equipment; the surface of the medicine containing patch is provided with a microstructure for assisting in adsorbing the surface of the skin, so that the adsorption force of the ultrasonic medicine feeding device and the skin can be enhanced; and the device also comprises an auxiliary probe which can be electrically connected with the main probe, and the administration area can be expanded.
Description
Technical Field
The invention relates to the technical field of medical instruments, in particular to an ultrasonic drug delivery device.
Background
With the development of society and the improvement of the level of science and technology, medical and health problems are paid more and more attention by people. Of the current treatments, pharmacological treatments are the most common treatment modalities. The therapeutic principle is that the medicine is transferred from the outside of the body to the inside of the body to produce the drug effect in a certain transportation mode.
Transdermal Drug Delivery (TDD) refers to a Drug that is absorbed through the skin at a certain rate and enters the blood circulation to achieve an effective blood concentration, thereby treating or preventing diseases. With the development of biotechnology, biological agents mainly comprising macromolecules such as polypeptides, proteins and oligonucleotides are increasing, and the administration route is a common problem encountered in clinical application of biological agents. Because the biological preparation is easily degraded in the liver and the gastrointestinal tract when being taken orally, the effective utilization rate of the biological preparation is reduced; when in injection, the stable blood concentration in the body is difficult to maintain, and the frequent injection causes great inconvenience and pain to patients. Therefore, transdermal administration is attracting attention as the third most important administration method other than oral administration and injection. Compared with the common administration mode, the transdermal administration has the following advantages:
(1) avoids the possible liver first pass effect and gastrointestinal tract inactivation when the medicine is taken orally, and improves the treatment effect.
(2) The dosage and the release time of the medicine are controlled, and the constant blood concentration in the body is ensured.
(3) The safety of the medicine is improved, if adverse reaction is found, the medicine can be stopped immediately, and the danger of oral administration or intramuscular injection is reduced.
(4) Provides a mild drug delivery mode, improves the adaptability of a drug receiver, and avoids the fear of needles seen by children and the inaccuracy of drug delivery caused by unfamiliarity of drug delivery schemes of the drug receiver.
The medical product using the percutaneous administration technology has clinical application in China, for example, the ultrasonic pulse conductance therapeutic apparatus is developed and produced by the new medical technology limited company of three waves in Henan, the apparatus mainly uses ultrasonic waves to enable the medicine to enter the body through the complete skin to play the local and whole body therapeutic effect, and simultaneously, the functions of interference electricity, low-frequency electricity and the like are superposed. An ultrasonic conductivity meter is produced by Nanchang Xinchang Changchang medical science and technology development limited company, and can form a specific artificial biological channel among skin, tissues and cells through high-end physical means such as electrical pore forming, ultrasonic cavitation and the like, and then through the powerful driving action of functions such as ultrasonic convection operation, radiation pressure and the like, the medicine directly enters diseased organs and tissues along the artificial biological channel, and a high-concentration infiltration area is formed locally and rapidly, so that the medicine is promoted to operate in the cells, and the therapeutic effect of the medicine is directly exerted.
However, in the practice of treatment, due to the limitation of the structure, there still exist many operational inconveniences, such as the patent with publication number CN208641537U, which discloses a transdermal drug delivery device comprising a housing, a first microneedle system, a second microneedle system and a pulse power source, although the transdermal drug delivery device can improve the transdermal drug delivery speed and transdermal drug delivery effect, and improve the therapeutic effect of the drug; however, the transdermal drug delivery device needs to be held for a long time when being applied, and the device needs to be fixed on a treatment part by auxiliary means such as a medical adhesive tape, and the transdermal drug delivery device needs to be used for many times, so that the device is troublesome to clean after being pasted by the medical adhesive tape and the like, and is easy to cause discomfort to the treatment part; in addition, since the transdermal drug delivery device is generally provided with a small area contacting the skin in order to treat different parts of the body, it requires many operations when the transdermal drug delivery device is used to treat a large area of the body, which wastes a lot of time.
Disclosure of Invention
In order to solve the above technical problem, the present invention provides an ultrasonic drug delivery device comprising: the main probe comprises an electrode plate, a rubberizing, an ultrasonic transducer, a patch carrier and a medicine containing patch; the electrode plate is arranged in the main probe shell and is bonded with the ultrasonic transducer through the adhesive tape; one surface of the patch carrier is fixed on the electrode sheet and keeps good contact with the surface of the electrode sheet around the electrode sheet, the other surface of the patch carrier is attached with the medicine containing patch which can be immersed in medicine liquid, and the electrode sheet and the electric wire of the ultrasonic transducer are led out through signal wires and connected with treatment equipment; the surface of the medicine containing patch is provided with a microstructure for assisting in adsorbing the surface of the skin.
Furthermore, the medicine containing patch comprises a first surface and a second surface, the first surface is attached to a patch carrier, the second surface is provided with a microstructure for assisting in absorbing the skin surface, the microstructure for assisting in absorbing the skin surface is a plurality of convex structures arranged on the second surface of the medicine containing patch, the convex structures are perpendicular to the second surface of the medicine containing patch, and the convex structures have rectangular sections, tapered sections, curved sections or irregular sections; when the drug containing patch is used, the second surface of the drug containing patch is attached to the skin, the convex structure is in contact with the skin and generates certain angle of deviation deformation so as to form adsorption force parallel to the surface of the skin and adsorption force vertical to the surface of the skin, and the adsorption force parallel to the surface of the skin is greater than the adsorption force vertical to the surface of the skin so that the drug containing patch slides relative to the skin.
Further, the ultrasonic drug delivery device comprises at least one auxiliary probe; the auxiliary probe comprises an electrode plate, a rubberizing, an ultrasonic transducer, a patch carrier and a medicine containing patch, wherein the electrode plate has the same internal structure as the main probe; a first hinge groove is formed in one side of the main probe shell, a hinge clamping column is connected to one side of the auxiliary probe through a connecting chain, the hinge clamping column is matched with the first hinge groove, and the auxiliary probe is inserted into the first hinge groove through the hinge clamping column and is electrically connected with the main probe; and a second hinge groove electrically connected with other auxiliary probes is arranged on the side surface of the auxiliary probe, which is back to the side surface connected with the hinge clamping column.
Furthermore, other side surfaces of the auxiliary probe are provided with hinge clamping columns or second hinge grooves which are electrically connected with the main probe or other auxiliary probes.
Furthermore, the connecting chain is of a flexible connecting structure, and the auxiliary probe can rotate at a certain angle relative to the main probe.
Furthermore, clamping grooves are formed in the shells of the main probe and the auxiliary probe, the patch carrier is a concave aluminum sheet with a conductive function, fixing pins matched with the clamping grooves are arranged on the edges of the concave aluminum sheet, and the fixing pins are inserted into the clamping grooves.
Furthermore, the medicine containing patch is a cake-shaped patch made of reticular silk material.
Further, the material of the convex structure may be a carbon nanotube material or a polyethylene resin material or a polypropylene resin material.
Furthermore, the main probe and the auxiliary probe shell are respectively provided with a signal display lamp on the surface deviating from the medicine containing patch, when the main probe and the auxiliary probe are communicated with the treatment equipment through signal lines, the signal display lamp emits a light signal, and when the main probe or the auxiliary probe has a signal fault, the signal display lamp on the fault probe does not emit light.
The invention has the beneficial effects that:
the electrode of the ultrasonic transducer is connected with an ultrasonic driving signal of a therapeutic instrument, and a vibration energy output surface is connected with an electrode plate into a rigid whole through adhesive tape, so that the electrode plate vibrates; the electrode plate is a metal wafer, is connected with an electric field and an electric pore-forming signal of the therapeutic apparatus, and acts on the skin of the human body through a patch carrier arranged on the surface of the electrode plate and a medicament adsorbed on the medicament containing patch to enhance the penetration of the medicament;
in order to enhance the adsorption force between the medicine containing patch and the skin, the medicine containing patch comprises a first surface and a second surface, the first surface is attached to a patch carrier, the second surface is provided with a microstructure for assisting in adsorbing the surface of the skin, the microstructure for assisting in adsorbing the surface of the skin is a plurality of convex structures arranged on the second surface of the medicine containing patch, the convex structures are perpendicular to the second surface of the medicine containing patch, and the convex structures have rectangular sections, conical sections, curved sections or irregular sections; when the patch is used, the second surface of the medicine containing patch 7 is attached to the skin, the convex structure is in contact with the skin and generates certain angle of deviation deformation so as to form adsorption force parallel to the surface of the skin and adsorption force vertical to the surface of the skin, and the adsorption force parallel to the surface of the skin is greater than the adsorption force vertical to the surface of the skin so as to prevent the medicine containing patch from slipping relative to the skin; in the radial direction of the convex structures, namely the direction parallel to the surface of the skin, the convex structures and the skin generate a maximum number of contact points, so that larger intermolecular acting force is generated, the medicine containing patch is firmly attached to the skin, and the medicine containing patch is prevented from sliding relative to the skin when a treatment part acts in the treatment process; even without additional auxiliary sticking means such as medical adhesive tapes and the like, the probe can be firmly adsorbed on the skin;
the ultrasonic drug delivery device comprises at least one auxiliary probe; a first hinge groove is formed in one side of the main probe shell, a hinge clamping column is connected to one side of the auxiliary probe through a connecting chain, the hinge clamping column is matched with the first hinge groove, and the auxiliary probe is inserted into the first hinge groove through the hinge clamping column and is electrically connected with the main probe; a second hinge groove electrically connected with other auxiliary probes is arranged on the side surface of the auxiliary probe 2 opposite to the side surface connected with the hinge clamping column; the auxiliary probe has the function of expanding the treatment area of the main probe, and when the main probe is connected with the auxiliary probe, the medicine containing patches arranged on the main probe and the auxiliary probe can simultaneously administer medicine to the skin with twice the area;
in order to further expand the administration area, other side surfaces of the auxiliary probes are provided with hinge clamping columns or second hinge grooves which are electrically connected with the main probe or other auxiliary probes, namely the main probe can be connected with a plurality of auxiliary probes, and the number of the auxiliary probes can be increased or decreased according to the area of the patient to be treated.
In addition, the connecting chain of the application is a flexible connecting structure, the auxiliary probe can rotate relative to the main probe by a certain angle, the structure can adapt to the change of the radian of the surface of the skin to be treated, and the structure can meet the requirement of administration to different parts.
In order to facilitate observation of the working state of each probe, a signal display lamp is respectively arranged on one surface of the shell of each probe, which is far away from the medicine containing patch, when the main probe and the auxiliary probe are communicated with treatment equipment through signal lines, the signal display lamps emit light signals, and when the main probe or the auxiliary probe has signal faults, the signal display lamps on the failed probes do not emit light, so that the structure ensures the safety and reliability of operation.
Drawings
FIG. 1 is a schematic view showing the internal structure of a main probe of an ultrasonic medicine delivery device according to the present invention;
FIG. 2 is a schematic view of the structure of the drug containing patch;
FIG. 3 is a schematic view of the external structure of the skin-attached side of the main probe of the ultrasonic medicine delivery device of the present invention;
FIG. 4 is a side view of the main probe of the ultrasonic drug delivery device of the present invention;
FIG. 5 is a schematic view of the external structure of the skin-attached side of the auxiliary probe of the ultrasonic medicine delivery device of the present invention;
FIG. 6 is a side view of the secondary probe of the ultrasonic drug delivery device of the present invention.
Wherein: the ultrasonic medical device comprises a main probe 1, a first hinge groove 1-1, an auxiliary probe 2-1, a hinge clamping column 2-1, a connecting chain 2-2, a second hinge groove 2-3, an ultrasonic transducer 3, an adhesive 4, an electrode plate 5, a patch carrier 6, a fixing pin 6-1, a drug containing patch 7, a convex structure 7-1, a clamping groove 8 and a signal line 9.
Detailed Description
The advantages, features and methods of accomplishing the same will become apparent from the drawings and the detailed description that follows.
Referring to fig. 1-6, an ultrasonic drug delivery device is provided, the device comprising: the main probe 1 comprises an electrode plate 5, a rubberizing 4, an ultrasonic transducer 3, a patch carrier 6 and a medicine containing patch 7; the electrode plate 5 is arranged inside the shell of the main probe 1 and is bonded with the ultrasonic transducer 3 through the adhesive tape 4; around the electrode plate 5, one surface of the patch carrier 6 is fixed on the electrode plate 5 and keeps good contact with the surface of the electrode plate 5, the other surface of the patch carrier 6 is attached with the medicine containing patch 7 which can be immersed in medicine liquid, and the electrode plate 5 and the electric wire of the ultrasonic transducer 3 are led out through a signal wire 9 and connected with treatment equipment; the surface of the medicine containing patch 7 is provided with a microstructure for assisting in absorbing the surface of the skin.
The electrode of the ultrasonic transducer is connected with an ultrasonic driving signal of a therapeutic instrument, and the vibration energy output surface is connected with the electrode plate into a rigid whole through the adhesive tape 4, so that the electrode plate vibrates; the electrode slice is a metal wafer, which is connected with an electric field and an electric pore-forming signal of the therapeutic apparatus, and acts on the skin of the human body through a patch carrier 6 arranged on the surface of the electrode slice and the medicament adsorbed on the medicament containing patch to enhance the penetration of the medicament;
the patch carrier 6 can be made of aluminum, so that the quality of the ultrasonic administration device can be reduced, and the patch carrier 6 in contact with the electrode plate is also an electrode of an electric field, so that two electric stimulation signals, namely an electric pore and the electric field of the treatment equipment are applied to a human body by the electrode, and the administration effect is improved.
In order to enhance the adsorption force between the medicine containing patch 7 and the skin, the medicine containing patch 7 comprises a first surface and a second surface, the first surface is attached to a patch carrier 6, the second surface is provided with a microstructure for assisting in adsorbing the skin surface, the microstructure for assisting in adsorbing the skin surface is a plurality of convex structures 7-1 arranged on the second surface of the medicine containing patch 7, the convex structures 7-1 are perpendicular to the second surface of the medicine containing patch 7, and the convex structures 7-1 have rectangular sections, tapered sections, curved sections or irregular sections; when the drug containing patch 7 is used, the second surface of the drug containing patch 7 is attached to the skin, the convex structure 7-1 is in contact with the skin and is deflected and deformed at a certain angle to form an adsorption force parallel to the skin surface and an adsorption force vertical to the skin surface, and the adsorption force parallel to the skin surface is greater than the adsorption force vertical to the skin surface to prevent the drug containing patch 7 from slipping relative to the skin.
In the radial direction of the convex structures 7-1, namely the direction parallel to the surface of the skin, a plurality of convex structures 7-1 generate a maximum number of contact points with the skin, so that large intermolecular acting force is generated, the medicine containing patch 7 is firmly attached to the skin, and the medicine containing patch 7 is prevented from slipping relative to the skin when a treatment part acts in the treatment process; even without additional auxiliary sticking means such as medical adhesive tapes and the like, the probe can be firmly adsorbed on the skin;
in addition, the ultrasonic medicine delivery device comprises at least one auxiliary probe 2; the auxiliary probe 2 comprises an electrode plate, a rubberizing, an ultrasonic transducer, a patch carrier and a medicine containing patch which are the same as the internal structure of the main probe 1; a first hinge slot 1-1 is formed in one side of a shell of the main probe 1, a hinge clamping column 2-1 is connected to one side of the auxiliary probe 2 through a connecting chain 2-2, the hinge clamping column 2-1 is matched with the first hinge slot 1-1, and the auxiliary probe 2 is inserted into the first hinge slot 1-1 through the hinge clamping column 2-1 and is electrically connected with the main probe 1; and a second hinge groove electrically connected with other auxiliary probes is arranged on the side surface of the auxiliary probe 2 opposite to the side surface connected with the hinge clamping column 2-1.
The auxiliary probe 2 is used for expanding the treatment area of the main probe, and when the main probe is connected with the auxiliary probe, the medicine containing patches arranged on the main probe and the auxiliary probe can simultaneously administer medicine to the skin with twice the area;
in order to further expand the administration area, the other side surfaces of the auxiliary probes 2 are respectively provided with a hinge clamping column 2-1 or a second hinge groove 2-3 which is electrically connected with the main probe or other auxiliary probes, namely the main probe can be connected with a plurality of auxiliary probes, and the number of the auxiliary probes can be increased or decreased according to the area of the patient to be treated.
And, the said link chain 2-2 is the flexible linkage, the said auxiliary probe 2 can take place the rotation of certain angle relative to the said main probe 1, its purpose is to adapt to the change of the surface radian of treating the skin, the administration to different positions of this structure can be satisfied.
The main probe 1 and the auxiliary probe 2 are provided with a clamping groove 8 on the outer shell, the patch carrier 6 is a concave aluminum sheet with a conductive function, the edge of the concave aluminum sheet is provided with a fixing pin 6-1 matched with the clamping groove 8, and the fixing pin 6-1 is inserted into the clamping groove 8.
The medicine containing patch 7 is a cake-shaped patch made of reticular silk material.
The material of the convex structure 7-1 can be carbon nanotube material or polyethylene resin material or polypropylene resin material, and the structure has enough elasticity, so that the convex structure 7-1 can be ensured to deform to a certain extent when contacting with the skin, and the adsorption effect is increased.
Furthermore, in order to observe the working state of each probe conveniently, a signal display lamp (not shown in the figure) is respectively arranged on one surface of the shell of the main probe 1 and one surface of the shell of the auxiliary probe 2, which is deviated from the medicine containing patch, when the main probe 1 and the auxiliary probe 2 are communicated with the treatment equipment through a signal line 9, the signal display lamp sends out a bright light signal, and when the main probe 1 or the auxiliary probe 2 has a signal fault, the signal display lamp on the probe with the fault does not emit light.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (9)
1. An ultrasonic drug delivery device, comprising: the main probe (1) comprises an electrode plate (5), a rubberizing (4), an ultrasonic transducer (3), a patch carrier (6) and a medicine containing patch (7); the electrode plate (5) is arranged inside the shell of the main probe (1) and is bonded with the ultrasonic transducer (3) through the adhesive tape (4); one surface of the patch carrier (6) is fixed on the electrode plate (5) and keeps good contact with the surface of the electrode plate (5) around the electrode plate (5), the medicine containing patch (7) which can be immersed in medicine liquid is attached to the other surface of the patch carrier (6), and the electrode plate (5) and the electric wire of the ultrasonic transducer (3) are led out through a signal wire (9) and are connected with treatment equipment; the surface of the medicine containing patch (7) is provided with a microstructure for assisting in adsorbing the surface of the skin.
2. An ultrasonic drug delivery device as defined in claim 1, wherein: the drug containing patch (7) comprises a first surface and a second surface, the first surface is attached to a patch carrier (6), the second surface is provided with a microstructure for assisting in absorbing the skin surface, the microstructure for assisting in absorbing the skin surface is a plurality of convex structures (7-1) arranged on the second surface of the drug containing patch (7), the convex structures (7-1) are perpendicular to the second surface of the drug containing patch (7), and the convex structures (7-1) have rectangular sections, tapered sections, curved sections or irregular sections; when the patch is used, the second surface of the medicine containing patch (7) is attached to the skin, the convex structures (7-1) are in contact with the skin and are deflected and deformed at a certain angle to form an adsorption force parallel to the skin surface and an adsorption force vertical to the skin surface, and the adsorption force parallel to the skin surface is greater than the adsorption force vertical to the skin surface to prevent the medicine containing patch (7) from slipping relative to the skin.
3. An ultrasonic drug delivery device as defined in claim 1, wherein: the ultrasonic drug delivery device at least comprises an auxiliary probe (2); the auxiliary probe (2) comprises an electrode plate, a rubberizing, an ultrasonic transducer, a patch carrier and a medicine containing patch, wherein the electrode plate has the same internal structure as the main probe (1); a first hinge groove (1-1) is formed in one side of a shell of the main probe (1), one side of the auxiliary probe (2) is connected with a hinge clamping column (2-1) through a connecting chain (2-2), the hinge clamping column (2-1) is matched with the first hinge groove (1-1), and the auxiliary probe (2) is inserted into the first hinge groove (1-1) through the hinge clamping column (2-1) and is electrically connected with the main probe (1); and a second hinge groove electrically connected with other auxiliary probes is arranged on the side surface of the auxiliary probe (2) opposite to the side surface connected with the hinge clamping column (2-1).
4. An ultrasonic drug delivery device as defined in claim 3, wherein: and the other side surfaces of the auxiliary probe (2) are provided with hinge clamping columns (2-1) or second hinge grooves (2-3) which are electrically connected with the main probe or other auxiliary probes.
5. An ultrasonic drug delivery device as defined in claim 3, wherein: the connecting chain (2-2) is of a flexible connecting structure, and the auxiliary probe (2) can rotate relative to the main probe (1) at a certain angle.
6. An ultrasonic drug delivery device as defined in claim 1, wherein: the main probe (1) and the auxiliary probe (2) are provided with clamping grooves (8) on the shells, the patch carrier (6) is a concave aluminum sheet with a conductive function, fixing feet (6-1) matched with the clamping grooves (8) are arranged on the edges of the concave aluminum sheet, and the fixing feet (6-1) are inserted into the clamping grooves (8).
7. An ultrasonic drug delivery device according to claim 1, characterized in that the drug containing patch (7) is in the form of a cake made of a mesh silk material.
8. An ultrasonic drug delivery device as defined in claim 2, wherein: the material of the convex structure (7-1) can be carbon nanotube material or polyethylene resin material or polypropylene resin material.
9. An ultrasonic drug delivery device as defined in claim 3, wherein: the main probe (1) with the one side that the shell of assistance probe (2) deviates from the medicine paster of holding is provided with the signal display lamp respectively, works as main probe (1) with when assisting probe (2) and being linked together through signal line (9) and treatment equipment, the signal display lamp sends the light signal, works as main probe (1) or when assisting probe (2) and breaking down, the signal display lamp on the probe that breaks down is luminous not.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202010203307.7A CN111467666A (en) | 2020-03-20 | 2020-03-20 | Ultrasonic medicine feeding device |
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| CN202010203307.7A CN111467666A (en) | 2020-03-20 | 2020-03-20 | Ultrasonic medicine feeding device |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112933390A (en) * | 2021-01-19 | 2021-06-11 | 温州市中西医结合医院 | Ultrasonic medicine introducing therapeutic apparatus for tonsil |
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