CN103446668A - Transdermal drug delivery therapeutic apparatus and transdermal drug delivery therapeutic method - Google Patents
Transdermal drug delivery therapeutic apparatus and transdermal drug delivery therapeutic method Download PDFInfo
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Abstract
The invention discloses a transdermal drug delivery therapeutic apparatus. The transdermal drug delivery therapeutic apparatus comprises a power circuit, an MCU main control module, a man-machine interaction device, an electroporation/ electricion lead-in circuit, an ultrasonic lead-in circuit and two therapeutic electrodes. The ultrasonic lead-in circuit comprises an ultrasonic oscillating circuit and a modulation circuit, wherein the signal output end of the modulation circuit is connected with the modulation signal input end of the ultrasonic oscillating circuit, and the modulation circuit is used for modulating ultrasonic signals produced by the ultrasonic oscillating circuit to obtain a plurality of ultrasonic signals with different frequencies. The invention further discloses a transdermal drug delivery therapeutic method. An ultrasonic lead-in therapeutic method includes the steps that one ultrasonic transducer corresponds to the ultrasonic oscillating circuit, and the ultrasonic signals of the ultrasonic oscillating circuit are modulated to obtain the ultrasonic signals having different frequencies and are then transmitted to the ultrasonic transducer. According to the transdermal drug delivery therapeutic apparatus and the transdermal drug delivery therapeutic method, the electroporation/ electricion lead-in drug delivery therapy and the ultrasonic wave lead-in drug delivery therapy can be conducted on a patient at the same time, therefore, a drug can be rapidly and efficiently led in the skin, and a better therapeutic effect is achieved.
Description
Technical field
The present invention relates to a kind for the treatment of equipment via skin and percutaneous dosing Therapeutic Method, relate in particular to a kind for the treatment of equipment via skin and percutaneous dosing Therapeutic Method that electroporation/electron ion imports drug treatment and ultrasonic therapy function that have concurrently.
Background technology
Transdermal delivery system refers to after the skin administration, and the medicine transdermal enters blood circulation and the therapeutic modality of a therapeutical effect.The percutaneous dosing treatment has the distinct advantages that surmounts general medication, can destroy without " first pass effect " and the gastrointestinal of liver, and the skin interbed also has the storage effect.Make the drug level curve mild, avoided " peak valley phenomenon ", is provided action time that can be scheduled to and longer, maintain and stablize lasting blood drug level, toxicity and untoward reaction are little, easy to use.The advantage that percutaneous dosing therapeutic equipment and method are unique with it, become recent domestic medicine worker's study hotspot, and development rapidly.
Traditional percutaneous dosing dosage form has the agent of bath, lotion, liniment, tincture, oil preparation, ointment, plaster, paste, bath agent etc.; The modern percutaneous dosing dosage form that the application macromolecular material grows up has membrane, gel, cataplasma, paster agent etc.Medicine enters human body by the skin naturally osmotic, will be by the horny layer of skin surface, horny layer is by fine and close cellularity, drug molecule extremely difficulty sees through, it is generally acknowledged that the lipophilic molecules that only has the micromolecule amount can pass horny layer by naturally osmotic and stop and enter human body, but the actual drug molecular species is various, complex structure, particularly protein-based, molecular weight is very large, therefore much physics appearred, the supplementary means of chemistry, for the percutaneous that promotes drug molecule, absorb, for example: chemical enhancement, iontophoresis, electroporation, ultrasonic importing, optical pressure imports, thermotherapy.
In disclosed patent documentation, introduction has and adopts the medicine of above-mentioned or several technology to import instrument, as: the patent No. is that " ZL201120526790.9 ", name are called the patent of " iontophoresis transdermal delivery device ", and this device only includes the iontophoresis function; Publication number is that " CN102397621A ", name are called the patent of " enclosed laser shock wave transdermal administration device ", adopts laser mode work; Publication number is that " CN1403173 ", name are called the patent of " electric perforating system for transdermal medication ", has adopted electroporation medicine introductory technique; Application number is that " CN200910303225.3 ", name are called the patent application of " a kind of method of ultrasound wave and electric field superposition target medicine penetration and instrument ", that this instrument has adopted is ultrasonic, electroporation, ion method carry out the medicine importing, but the ultrasonic signal of an only corresponding frequency of ultrasonic transducer, its ultrasonic therapeutic effect is not good enough.
Following other non-patent literature is also introduced various traditional percutaneous dosing treatment technologies:
Bao Jiali, wait seapeak, and the Li Hong drug percutaneous is controlled physical technique [J] Chinese Journal of Medical Instrumentation discharged, 2004,28 (5): 313-318;
Li Liangcheng, Zhang Yongshun, short development [J] the biomedical engineering magazine that oozes equipment of the red ultrasonic medicinal of Li Zhong, 2009,26 (1): 185-186;
Wang Fei, progress [J] the Inpharm research magazine of the short infiltration method use in conjunction of high Shen transdermal, 2007,34 (4): 285-285;
The Chinese primary health care of the progress of Yan Shi transdermal medicine for treating [J], 2009,23 (3): 82-82;
Yang Fangfang, Zhang Yongping promotes application general introduction [J] Guiyang College of Traditional Chinese Medicine journal of Drug Percutaneous Absorption physical method, 2006,28 (2): 41-41;
Zhang Xiaoyi, the Zhang Zhongyuan ultrasound wave promotes plant amedica Transdermal absorption mechanism [J] external treatment with Chinese medicine magazine, 2002,11 (2): 5-5;
Zhou Pengju, Deng Shengqi, fly new development [J] Acta Pharmaceutica Sinica that target administration is studied, 2010,45 (3): 300-306 before Gong;
Zhang Guoliang ，Shi Zong road. the progress of low frequency ultrasound transdermal administration [J]. West China pharmaceutical journal, 2001,16 (5): 367-368;
Gong Xiufen. the non-linear research of the acoustics in medical ultrasonic [J]. Proceedings in Physics, 1996,9(2): 286～296;
In the data of above-mentioned various documents, iontophoresis has had very long use history, and cation penetrates skin at the anode place, and anion penetrates skin at the negative electrode place, and neutral particle also can penetrate skin under the effect of electric osmose.The electroporation method is on the basis of iontophoresis, adopts the pulse of high pressure to be processed skin, makes skin surface form temporary transient hydrophilic duct, helps to make medicine enter more smoothly skin.Ultrasonic importing is also the nearlyer new technique for transdermal administration, the comprehensive functions such as hyperacoustic cavitation and non-cavitation, convection current transportation, deep-heating effect have been utilized, ultrasound wave imports owing to not being subject to the drug molecule polarity effect, and the medicine adaptability is better than iontophoresis.
But adopt single means, for example: adopt merely electroporation, iontophoresis, thermotherapy, ultrasonic its limitation arranged, can't make medicine be seen through fast and effectively, particularly Chinese medicine, because complicated component, its effective ingredient may comprise different types of drug molecule.Adopt the multiple means synergism, than adopting single lead-in mode more can increase work efficiency, strengthen effect, particularly ultrasound wave that medicine imports, can significantly strengthen the transdermal penetration amount.
When supersonic medicine imports, frequency is a most important parameter, high frequency ultrasound (more than 800Khz) and low frequency ultrasound (100Khz is following) demonstrate different effects, and the medicine that each self adaptation is dissimilar, therefore adopt the ultrasonic importing of single-frequency that its inborn defect is arranged.Address this problem, just need equipment can produce high frequency ultrasound and also can produce low frequency ultrasound.Yet ultrasonic transducer has a fixing resonant frequency, can not be operated in low frequency and be operated in again high frequency, it is all to adopt single frequency that therefore existing ultrasonic medicinal imports.Seen the equipment of the ultrasonic importing of employing of mentioning in open source information, all to adopt single-frequency ultrasonic, adopt high frequency ultrasound (more than 800Khz), adopt low frequency ultrasound (100Khz is following), but the ultrasound wave of different frequency for different medicines, mechanism is different, so single-frequency is ultrasonic can not well adapt to various kinds of drug.
The people's such as Schoellhammer in 2012 a research, mentioned the importing experiment of a double-frequency ultrasound, having shown that double frequency is worked simultaneously can reach better effect, this experiment adopts the ultrasound wave of two frequencies of height to import (a 1Mhz simultaneously, a 20Khz), result shows that mechanism can reach the several times of single-frequency, experimental result prompting double-frequency ultrasound has reached the effect that 1+1 is greater than 2, as shown in Figure 1, top Curves is shown the mechanism of double-frequency ultrasound, below Curves be shown the ultrasonic mechanism of single-frequency.But this research adopts two ultrasonic transducers to work simultaneously, although reached reasonable effect, uses two transducer architecture complexity simultaneously, bulky, does not possess engineering practicability, can't be for clinical treatment.
When carrying out the medicine importing, due to the ingredient complexity, molecule is similar various, molecular size range differs, architectural difference is large, for different medicines, need to find out by experiment corresponding, different treatment parameter combinations, comprise electroporation, the waveform that electric conductance enters, frequency, dutycycle, the combination of the parameters such as ultrasonic, these all need to be tested and determine for different medicines, therefore need the treatment parameter combinations of the necessary various medicines of built-in correspondence of instrument, if all medicines only adopt a kind of fixing parameter to be imported, understand some medicines and import very poor of effect.
Summary of the invention
Purpose of the present invention provides a kind for the treatment of equipment via skin and percutaneous dosing Therapeutic Method that electroporation/electron ion imports treatment and ultrasonic importing treatment function that have concurrently with regard to being in order to address the above problem.
In order to achieve the above object, the present invention has adopted following technical scheme:
Treatment equipment via skin of the present invention comprises power circuit, the MCU main control module, human-computer interaction device, electroporation/electron ion imports circuit, ultrasonic importing circuit, the first therapeutic electrode and the second therapeutic electrode, the control output end of described MCU main control module is connected with the control input end of described ultrasonic importing circuit with the control input end of described electroporation/electron ion importing circuit respectively, comprise ultrasonic transducer in described the first therapeutic electrode and/or described the second therapeutic electrode, the signal output part that described electroporation/electron ion imports circuit is connected with described the second therapeutic electrode with described the first therapeutic electrode respectively, the signal output part of described ultrasonic importing circuit is connected with the input of described ultrasonic transducer, described ultrasonic importing circuit comprises sonic oscillation circuit and modulation circuit, the signal output part of described modulation circuit is connected with the modulation signal input of described sonic oscillation circuit, and described modulation circuit is modulated to obtain the ultrasonic signal of a plurality of different frequencies for the ultrasonic signal that described sonic oscillation circuit is produced.
After adopting modulation circuit to be modulated (being specially amplitude modulation, frequency modulation and/or phase modulation) to ultrasonic signal, the ultrasonic signal that the ultrasonic signal of sonic oscillation circuit output is a plurality of different frequencies only increases the purpose that a modulation circuit realizes a plurality of frequency ultrasonic signal outputs on the basis of a ultrasonator and a ultrasonic transducer.
Particularly, described electroporation/electron ion imports circuit and comprises high-voltage amplifier and controlled current source loads, be provided with a DAC circuit and the 2nd DAC circuit in described MCU main control module, the signal output part of a described DAC circuit is connected with the signal input part of described high-voltage amplifier, the signal output part of described the 2nd DAC circuit is connected with an end of described controlled current source loads, and the signal output part of described high-voltage amplifier is connected with described the second therapeutic electrode with described the first therapeutic electrode respectively with the other end of described controlled current source loads.The waveform that can output waveform can change arbitrarily by the DAC circuit imports treatment for electroporation/electron ion.
Further, also be provided with the first adc circuit and the second adc circuit in described MCU main control module, the signal input part of described the first adc circuit is connected with described high-voltage amplifier, and the signal input part of described the second adc circuit is connected with described controlled current source loads.
As preferably, all comprise ultrasonic transducer in described the first therapeutic electrode and described the second therapeutic electrode, described sonic oscillation circuit comprises the first sonic oscillation circuit and the second sonic oscillation circuit, and described modulation circuit comprises the first modulation circuit and the second modulation circuit.
Further, described treatment equipment via skin also comprises the rfid circuit for detection of the radio-frequency (RF) tag information in drug packaging, and the outfan of described rfid circuit connects with the corresponding I/O end of described MCU main control module.
Percutaneous dosing Therapeutic Method of the present invention, be included in two therapeutic electrodes generation pulse currents and realize that electroporation/electron ion imports treatment, and realize ultrasonic importing treatment by the ultrasonic transducer generating ultrasonic signal in one or two therapeutic electrode, in described ultrasonic importing Therapeutic Method, ultrasonic transducer is corresponding connects a sonic oscillation circuit, and the ultrasonic signal that this sonic oscillation circuit is produced is transferred to this ultrasonic transducer after being modulated and obtain the ultrasonic signal of a plurality of different frequencies again.
Particularly, describedly be modulated to one or more in amplitude modulation, frequency modulation and phase modulation; Wherein, described amplitude modulation method is as follows: the power supply of the low frequency signal Modulated Ultrasonic oscillating circuit that is f2 by a road frequency, the resonant frequency of this sonic oscillation circuit is f1, the envelope of the ultrasonic signal of ultrasonic transducer output is low frequency signal, thereby obtains the ultrasonic signal that three frequencies are respectively f1, f1+f2, f1-f2.
Further, described percutaneous dosing Therapeutic Method also comprises: the treatment parameter combinations that first is determined by experiment various kinds of drug the best, the prefabricated multiple therapeutic scheme for different pharmaceutical also is stored in control module, during treatment, identify the radio-frequency (RF) tag information on drug packages by REID, according to the drug information recognized and prefabricated therapeutic scheme, by control module, automatically select corresponding therapeutic scheme to be treated.
Further, described percutaneous dosing Therapeutic Method also comprises: measure in real time skin voltage by adc circuit, through calculating Skin Resistance, by the impedance of record, demonstration skin, for the short effect of oozing of user assessment.
Beneficial effect of the present invention is:
Can realize that by the present invention the patient being carried out to electroporation/electron ion imports drug treatment and ultrasound wave importing drug treatment simultaneously, make medicine fast and effeciently import skin, realize better therapeutic effect.Imbody is in the following areas:
1, can the DAC circuit by the MCU main control module produce the electroporation of random waveform/electron ion and import the signal of telecommunication, can change ultrasonic dutycycle by the MCU main control module, and the combination of multiple import plan, allow operator to choose prefabricated appointment import plan according to different medicines, to adapt to different medicines, thereby improve the efficiency that medicine imports;
2, adopt the method for Modulated Ultrasonic ripple, only use single ultrasonic transducer (being ultrasonic vibrator) to realize the function of multiple frequency ultrasonic, take up room little, be convenient to application, because modulating frequency can change in a scope, and modulation signal is to be produced by main control module, changeable frequency, so this therapeutic instrument can be exported the ultrasound wave of multifrequency and frequency conversion.
3, pass through rfid circuit, can further realize automatic adaptation: read the RFID label information on the medicine packing by RF identification, after obtaining drug information, the parameters that Automatically invoked adapts, reduce the workload of user, reduced the maloperation probability.
The accompanying drawing explanation
Fig. 1 is the medicine mechanism schematic diagram of the ultrasonic and double-frequency ultrasound of single-frequency;
Fig. 2 is the circuit block diagram for the treatment of equipment via skin of the present invention.
The specific embodiment
Below in conjunction with accompanying drawing, the present invention is further described in detail:
As shown in Figure 2, treatment equipment via skin of the present invention comprises power circuit, the MCU main control module, human-computer interaction device, the first therapeutic electrode, the second therapeutic electrode, high-voltage amplifier, controlled current source loads, the first modulation circuit, the second modulation circuit, the first sonic oscillation circuit, the second sonic oscillation circuit and rfid circuit, the MCU main control module is provided with two-way DAC and two-way ADC, two-way DAC i.e. a DAC circuit (i.e. DAC1 in figure) and the 2nd DAC circuit (i.e. DAC2 in figure), two-way ADC i.e. the first adc circuit (i.e. ADC1 in figure) and the second adc circuit (i.e. ADC2 in figure), the signal output part of the one DAC circuit is connected with the signal input part of high-voltage amplifier, the 2nd DAC circuit signal outfan is connected with an end of controlled current source loads, the signal input part of the first adc circuit is connected with high-voltage amplifier, the signal input part of the second adc circuit is connected with controlled current source loads, the signal output part of high-voltage amplifier is connected with the second therapeutic electrode with the first therapeutic electrode respectively with the other end of controlled current source loads, the first therapeutic electrode and the second therapeutic electrode all comprise ultrasonic transducer, two ultrasonic control output ends of MCU main control module are connected with the control end of the second sonic oscillation circuit with the control end of the first sonic oscillation circuit respectively, and the ultrasonic signal outfan of the ultrasonic signal outfan of the first sonic oscillation circuit and the second sonic oscillation circuit is connected with the input of the ultrasonic transducer of the second therapeutic electrode with the input of the ultrasonic transducer of the first therapeutic electrode respectively, two modulation signal outfans of MCU main control module are connected with the input of the second modulation circuit with the input of the first modulation circuit respectively, and the outfan of the outfan of the first modulation circuit and the second modulation circuit is connected with the modulation input of the second sonic oscillation circuit with the modulation input of the first sonic oscillation circuit respectively, rfid circuit is for detection of the radio-frequency (RF) tag information in drug packaging, and the outfan of rfid circuit connects with the corresponding I/O end end of MCU main control module.
Also show power circuit in Fig. 2, power circuit is comprised of attaching plug, overcurrent protective device, transformator, current rectifying and wave filtering circuit, high tension generator.At electroporation with electro-ionic the time, required ceiling voltage difference, when electroporation, the about 200V voltage of the highest needs, iontophoresis is generally tens V voltages, so comprises a controlled high tension generator in power circuit, can control its output 50V or 200V voltage.Power circuit also is responsible for providing the required 5V of control section and 3.3V power supply, also exports in addition the 50V DC voltage for ultrasonic part.The structure of above-mentioned power circuit is conventional structure.
In addition, MCU main control module, high-voltage amplifier, controlled current source loads and human-computer interaction device are all conventional electronic units, wherein, the MCU main control module is the control section of complete machine, MCU, reset circuit, two-way DAC, two-way ADC, consist of, DAC imports the required signal of telecommunication for generation of electroporation and electron ion, and ADC changes for real-time human body Skin Resistance, measurement result can, for assessment of short effect of oozing, can supply the reference of doctor as treatment; Measurement result can be for the doctor as the reference for the treatment of; High-voltage amplifier and controlled current source loads form electroporation and electro-ionic critical piece jointly.Human body skin by therapeutic electrode and controlled constant current source-series after, as the load of high-voltage amplifier.Human-computer interaction device by LED or LCD as demonstration, with button (physical button or touch key-press) input of control commands.
As shown in Figure 2, during use, the first therapeutic electrode and the second therapeutic electrode directly act on patient skin, and the drug treatment method of whole treatment equipment via skin is as follows:
Before treatment, first be determined by experiment the treatment parameter combinations of various kinds of drug the best, the prefabricated multiple therapeutic scheme for different pharmaceutical also is stored in the MCU main control module.
During treatment, read the radio-frequency (RF) tag information (being RFID information) on identification treatment tablet package by rfid circuit, the MCU main control module can be according to the drug data read and prefabricated therapeutic scheme, and configuration meets electroporation, electron ion and the ultrasonic running parameter of this kind of medicine voluntarily.But the operator is manual configuration also.
When electroporation imports treatment, MCU master control module controls power circuit output 200V high pressure, power supply as high-voltage amplifier, required electroporation waveform, two-way DAC output in the MCU main control module, the one DAC circuit amplifies through high-voltage amplifier, become 100～200V high-voltage pulse, through the first therapeutic electrode and the second therapeutic electrode, enter in patient skin, because its electric current is subject to the restriction of controlled current source loads, so can avoid excessive electric current to damage the patient, controlled current source loads is set by the 2nd DAC circuit in the MCU main control module, both can export fixed level, also can export prefabricated waveform.
When electron ion imports treatment, MCU master control module controls power circuit output 50V, as the power supply of high-voltage amplifier, operation principle is identical with electroporation, but its running voltage, waveform, electric current all arrange difference.
During ultrasonic importing treatment, produce the ultrasonic control signal of two-way by the MCU main control module and send to respectively the first sonic oscillation circuit and the second sonic oscillation circuit, make it produce respectively ultrasonic signal, simultaneously, produce the two-way low frequency signal as modulating frequency by the MCU main control module, pass through respectively the first modulation circuit and the second modulating circuit modulates to the two-way ultrasonic signal.The frequency of carrier wave is determined by the resonant frequency of the ultrasonic transducer in therapeutic electrode itself.For the ultrasonic transducer of 1Mhz, the general value of modulating frequency is tens of Khz, and this is because the limited bandwidth of ultrasonic transducer.Ultrasonic signal corresponding to above-mentioned each therapeutic electrode comprises the ultrasonic signal of three different frequencies, the ultrasonic signal of a plurality of different frequencies obtains in the following manner: the power supply of the low frequency signal that is f2 by a road frequency (being produced by the MCU main control module) Modulated Ultrasonic oscillating circuit, the resonant frequency of this sonic oscillation circuit is f1, it is high frequency, the envelope of the ultrasonic signal of ultrasonic transducer output is low frequency signal, thereby obtains the ultrasonic signal that three frequencies are respectively f1, f1+f2, f1-f2.
What the ultrasonic transducer in therapeutic electrode was launched is the signal after modulation, three frequencies are respectively the ultrasonic signal of f1, f1+f2, f1-f2, ultrasound wave is propagated in tissue, tissue is nonlinear dielectric for ultrasound wave, due to nonlinear effect, can produce a series of frequency multiplication, difference frequency and frequency, thereby by the f2 demodulation out, comprise the f2 component in new spectrum component, realized that high frequency, low frequency work simultaneously, realized that an electrode only uses a ultrasonic transducer, carried out the high and low frequency importing simultaneously.
In said process, also by the adc circuit in the MCU main control module, measure in real time skin voltage, through calculating Skin Resistance, by the impedance of record, demonstration skin, for the short effect of oozing of user assessment.
Claims (10)
1. a treatment equipment via skin, comprise power circuit, the MCU main control module, human-computer interaction device, electroporation/electron ion imports circuit, ultrasonic importing circuit, the first therapeutic electrode and the second therapeutic electrode, the control output end of described MCU main control module is connected with the control input end of described ultrasonic importing circuit with the control input end of described electroporation/electron ion importing circuit respectively, comprise ultrasonic transducer in described the first therapeutic electrode and/or described the second therapeutic electrode, the signal output part that described electroporation/electron ion imports circuit is connected with described the second therapeutic electrode with described the first therapeutic electrode respectively, the signal output part of described ultrasonic importing circuit is connected with the input of described ultrasonic transducer, it is characterized in that: described ultrasonic importing circuit comprises sonic oscillation circuit and modulation circuit, the signal output part of described modulation circuit is connected with the modulation signal input of described sonic oscillation circuit, and described modulation circuit is modulated to obtain the ultrasonic signal of a plurality of different frequencies for the ultrasonic signal that described sonic oscillation circuit is produced.
2. treatment equipment via skin according to claim 1, it is characterized in that: described electroporation/electron ion imports circuit and comprises high-voltage amplifier and controlled current source loads, be provided with a DAC circuit and the 2nd DAC circuit in described MCU main control module, the signal output part of a described DAC circuit is connected with the signal input part of described high-voltage amplifier, the signal output part of described the 2nd DAC circuit is connected with an end of described controlled current source loads, the signal output part of described high-voltage amplifier is connected with described the second therapeutic electrode with described the first therapeutic electrode respectively with the other end of described controlled current source loads.
3. treatment equipment via skin according to claim 2, it is characterized in that: also be provided with the first adc circuit and the second adc circuit in described MCU main control module, the signal input part of described the first adc circuit is connected with described high-voltage amplifier, and the signal input part of described the second adc circuit is connected with described controlled current source loads.
4. treatment equipment via skin according to claim 1, it is characterized in that: in described the first therapeutic electrode and described the second therapeutic electrode, all comprise ultrasonic transducer, described sonic oscillation circuit comprises the first sonic oscillation circuit and the second sonic oscillation circuit, and described modulation circuit comprises the first modulation circuit and the second modulation circuit.
5. according to claim 1,2 or 3 described treatment equipment via skins, it is characterized in that: described treatment equipment via skin also comprises the rfid circuit for detection of the radio-frequency (RF) tag information in drug packaging, and the outfan of described rfid circuit connects with the corresponding I/O end of described MCU main control module.
6. a percutaneous dosing Therapeutic Method, be included in two therapeutic electrodes generation pulse currents and realize that electroporation/electron ion imports treatment, and realize ultrasonic importing treatment by the ultrasonic transducer generating ultrasonic signal in one or two therapeutic electrode, it is characterized in that: in described ultrasonic importing Therapeutic Method, ultrasonic transducer is corresponding connects a sonic oscillation circuit, and the ultrasonic signal that this sonic oscillation circuit is produced is transferred to this ultrasonic transducer after being modulated and obtain the ultrasonic signal of a plurality of different frequencies again.
7. percutaneous dosing Therapeutic Method according to claim 5 is characterized in that: describedly be modulated to one or more in amplitude modulation, frequency modulation and phase modulation.
8. percutaneous dosing Therapeutic Method according to claim 6, it is characterized in that: described amplitude modulation method is as follows: the power supply of the low frequency signal Modulated Ultrasonic oscillating circuit that is f2 by a road frequency, the resonant frequency of this sonic oscillation circuit is f1, the envelope of the ultrasonic signal of ultrasonic transducer output is low frequency signal, thereby obtains the ultrasonic signal that three frequencies are respectively f1, f1+f2, f1-f2.
9. according to claim 5,6 or 7 described percutaneous dosing Therapeutic Method, it is characterized in that: described percutaneous dosing Therapeutic Method also comprises: the treatment parameter combinations that first is determined by experiment various kinds of drug the best, the prefabricated multiple therapeutic scheme for different pharmaceutical also is stored in control module, during treatment, identify the radio-frequency (RF) tag information on drug packages by REID, according to the drug information recognized and prefabricated therapeutic scheme, by control module, automatically select corresponding therapeutic scheme to be treated.
10. according to claim 5,6 or 7 described percutaneous dosing Therapeutic Method, it is characterized in that: described percutaneous dosing Therapeutic Method also comprises: by adc circuit, measure in real time skin voltage, through calculating Skin Resistance, by the impedance of record, demonstration skin, for the short effect of oozing of user assessment.
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| CN104107503A (en) * | 2014-08-01 | 2014-10-22 | 北京中美联医学科学研究院有限公司 | Intermediate-frequency-modulated low frequency sonophoresis system |
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