CN203417491U - Fast separating and purifying device for organic compounds - Google Patents
Fast separating and purifying device for organic compounds Download PDFInfo
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- CN203417491U CN203417491U CN201320511049.4U CN201320511049U CN203417491U CN 203417491 U CN203417491 U CN 203417491U CN 201320511049 U CN201320511049 U CN 201320511049U CN 203417491 U CN203417491 U CN 203417491U
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Abstract
The utility model relates to a fast separating and purifying device for organic compounds. The device comprises a liquid storage tank, a liquid transfer pump, an automatic switching valve, a chromatography column, a detector and a collector, wherein a four-way valve is adopted as the automatic switching valve; the liquid storage tank is connected with a liquid inlet of the liquid transfer pump through a pipeline; a liquid outlet of the liquid transfer pump is connected with a first interface of the automatic switching valve through another pipeline; a second interface of the automatic switching valve is connected with one end of the chromatography column; a third interface of the automatic switching valve is connected with the other end of the chromatography column; a fourth interface of the automatic switching valve is connected with the detector; the detector is connected with the collector through another pipeline; the automatic switching valve controls the flow direction of a channel in the chromatography column, so as to enable the chromatography column to elute in forward direction and elute in reverse direction. Due to the adoption of the device, the problems that in a separating and purifying process of a sample having two components with large polarity difference, a long time is consumed, much flowing phase is consumed, the flowing phase cannot be recycled, the component recovering rate is low, and the like, are solved.
Description
Technical field
The utility model relates to a kind of organic compound fast separating and purifying device for liquid chromatogram system.
Background technology
In Separation of Organic Compounds purge process, two polarity in sample are differed to larger composition, in column chromatography elution process at present, if only use a kind of mobile phase of single ratio, want two samples all to elute, need to take a long time, use a lot of mobile phases.After if first composition elutes, with regard to changing the mobile phase of a ratio, carry out elution samples, although elution time has shortened, but mobile phase ratio is inaccurate, cause mobile phase cannot reclaim use, cause the increase of cost, and after by the composition under wash-out, after whole chromatographic column, increase the adsorbance between itself and filler, reduced the rate of recovery of this composition.Especially in industrial production, this phenomenon is badly in need of improving.
Utility model content
In order to overcome above-mentioned defect, the utility model provides a kind of organic compound fast separating and purifying device.This organic compound fast separating and purifying device is simple to operate, and energy consumption is little, consuming time short, can avoid the mobile phase ratio of recovery inaccurate, can improve the composition rate of recovery in sample.
For realizing above-mentioned technical purpose, reach above-mentioned technique effect, the utility model is achieved through the following technical solutions: a kind of organic compound fast separating and purifying device, comprise reservoir, infusion pump, automatic transfer valve, chromatography post, detector and collector, described automatic transfer valve is cross valve, described reservoir is connected with the inlet of described infusion pump by pipeline, the liquid outlet of described infusion pump is connected with the first interface of described automatic transfer valve by pipeline, the second interface of described automatic transfer valve is connected with one end of described chromatography post, the 3rd interface of described automatic transfer valve is connected with the other end of described chromatography post, the 4th interface of described automatic transfer valve is connected with described detector, described detector is connected with described collector by pipeline, automatic transfer valve is controlled the flow direction of the stream in chromatography post, make chromatography post carry out positive direction wash-out and opposite direction wash-out.
The beneficial effects of the utility model are: adopt organic compound fast separating and purifying device of the present utility model to carry out separation and purification to organic matter, by the control of automatic transfer valve, can change the direction of the stream in chromatography post, first carry out positive direction wash-out and then carry out opposite direction wash-out, solved and only had two kinds of polarity to differ compared with the length consuming time in the sample separation purge process of large composition, expend the problems such as mobile phase is many, mobile phase cannot reclaim use, the composition rate of recovery is low.The utility model can shorten chromatography column chromatography elution time, reduces mobile phase use amount, can reclaim mobile phase, improves the composition rate of recovery in sample.
Accompanying drawing explanation
Fig. 1 is structural representation and the flow circuit diagram of the utility model positive direction wash-out.
Fig. 2 is the utility model structural representation and flow circuit diagram of wash-out in the other direction.
Number in the figure explanation: 1: reservoir; 2: infusion pump; 3: automatic transfer valve; 4: chromatography post; 5: detector; 6: collector; 7: the first interface of automatic transfer valve; 8: the second interface of automatic transfer valve; 9: the 3rd interface of automatic transfer valve; 10: the 4th interface of automatic transfer valve.
The specific embodiment
Below in conjunction with accompanying drawing, preferred embodiment of the present utility model is described in detail, thereby so that advantage of the present utility model and feature can be easier to be it will be appreciated by those skilled in the art that, protection domain of the present utility model is made to more explicit defining.
As depicted in figs. 1 and 2, a kind of organic compound fast separating and purifying device, comprise reservoir 1, infusion pump 2, automatic transfer valve 3, chromatography post 4, detector 5 and collector 6, described automatic transfer valve 3 is cross valve, described reservoir 1 is connected with the inlet of described infusion pump 2 by pipeline, the liquid outlet of described infusion pump 2 is connected with the first interface 7 of described automatic transfer valve by pipeline, the second interface 8 of described automatic transfer valve is connected with one end of described chromatography post 4, the 3rd interface 9 of described automatic transfer valve is connected with the other end of described chromatography post 4, the 4th interface 10 of described automatic transfer valve is connected with described detector 5, described detector 5 is connected with described collector 6 by pipeline, automatic transfer valve 3 is controlled the flow direction of the stream in chromatography post 4, make chromatography post 4 carry out positive direction wash-out and opposite direction wash-out.
Utilize this organic compound fast separating and purifying device, according to following steps, organic compound carried out to separation and purification:
The first step, as shown in Figure 1, the first interface of automatic transfer valve 7 and the second interface 8 of automatic transfer valve are connected and the 3rd interface 9 of automatic transfer valve and the 4th interface 10 connections of automatic transfer valve, infusion pump 2 sucks mobile phase export from reservoir 1, mobile phase carries sample and enters and in chromatography post 4, carry out positive direction wash-out, the first composition that 5 pairs of detectors elute detects, and the first composition eluting enters collector 6 and collects, and waste liquid finally flows into waste liquid bottle;
Second step, as shown in Figure 2, switch automatic transfer valve 3, the first interface of automatic transfer valve 7 and the 3rd interface 9 of automatic transfer valve are connected and the second interface 8 of automatic transfer valve and the 4th interface 10 connections of automatic transfer valve, mobile phase carries sample and enters and in chromatography post 4, carry out opposite direction wash-out, wash-out is isolated with the first compositional polarity and is differed larger the second composition, the second composition that 5 pairs of detectors elute detects, the second composition eluting enters collector 6 and collects, and waste liquid finally flows into waste liquid bottle;
The 3rd step, records the total elution time of chromatography post, the mobile mutual-assistance consumption of record, evaporate and reclaim used mobile phase, the mobile phasor that measurement is recovered to records the amount that the first composition and the second composition obtain simultaneously, and calculates the rate of recovery of the first composition and the second composition.
Wherein, the mobile phase that the mobile phase of described positive direction wash-out and wash-out employing is in the other direction same ratio.
Adopt organic compound fast separating and purifying device of the present utility model to carry out organic separation and purification, utilize the mobile phase of same ratio, by the control of automatic transfer valve, first sample is carried out to positive direction wash-out and then carry out opposite direction wash-out, solved and only had two kinds of polarity to differ compared with the length consuming time in the sample separation purge process of large composition, expend the problems such as mobile phase is many, mobile phase cannot reclaim use, and the composition rate of recovery is low.
It is emphasized that: be only preferred embodiment of the present utility model above, not the utility model is done to any pro forma restriction, any simple modification, equivalent variations and modification that every foundation technical spirit of the present utility model is done above embodiment, all still belong in the scope of technical solutions of the utility model.
Claims (1)
1. an organic compound fast separating and purifying device, it is characterized in that: comprise reservoir, infusion pump, automatic transfer valve, chromatography post, detector and collector, described automatic transfer valve is cross valve, described reservoir is connected with the inlet of described infusion pump by pipeline, the liquid outlet of described infusion pump is connected with the first interface of described automatic transfer valve by pipeline, the second interface of described automatic transfer valve is connected with one end of described chromatography post, the 3rd interface of described automatic transfer valve is connected with the other end of described chromatography post, the 4th interface of described automatic transfer valve is connected with described detector, described detector is connected with described collector by pipeline, automatic transfer valve is controlled the flow direction of the stream in chromatography post, make chromatography post carry out positive direction wash-out and opposite direction wash-out.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320511049.4U CN203417491U (en) | 2013-08-21 | 2013-08-21 | Fast separating and purifying device for organic compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320511049.4U CN203417491U (en) | 2013-08-21 | 2013-08-21 | Fast separating and purifying device for organic compounds |
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| Publication Number | Publication Date |
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| CN203417491U true CN203417491U (en) | 2014-02-05 |
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| CN201320511049.4U Withdrawn - After Issue CN203417491U (en) | 2013-08-21 | 2013-08-21 | Fast separating and purifying device for organic compounds |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394211A (en) * | 2013-08-21 | 2013-11-20 | 利穗科技(苏州)有限公司 | Apparatus for rapidly separating and purifying organic compounds and separation and purification method |
-
2013
- 2013-08-21 CN CN201320511049.4U patent/CN203417491U/en not_active Withdrawn - After Issue
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103394211A (en) * | 2013-08-21 | 2013-11-20 | 利穗科技(苏州)有限公司 | Apparatus for rapidly separating and purifying organic compounds and separation and purification method |
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| Date | Code | Title | Description |
|---|---|---|---|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| AV01 | Patent right actively abandoned |
Granted publication date: 20140205 Effective date of abandoning: 20150121 |
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| RGAV | Abandon patent right to avoid regrant |