CN203490202U - High performance liquid chromatograph - Google Patents
High performance liquid chromatograph Download PDFInfo
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- CN203490202U CN203490202U CN201320588853.2U CN201320588853U CN203490202U CN 203490202 U CN203490202 U CN 203490202U CN 201320588853 U CN201320588853 U CN 201320588853U CN 203490202 U CN203490202 U CN 203490202U
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- high performance
- performance liquid
- liquid chromatograph
- mixer
- pressure pump
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Abstract
A high performance liquid chromatograph comprises a liquid accumulator, a mixer, a high-pressure pump, a sample injector, a chromatographic column, a detector and a recorder which are connected in sequence, wherein a solvent filter is arranged on a liquid inlet pipe of the liquid accumulator, a thermostat is arranged between the sample injector and the chromatographic column, the output port of the detector is connected with a circulating pipe, and the other end of the circulating pipe is connected to a flow path switch valve between the mixer and the high-pressure pump. The high performance liquid chromatograph has a superstrong chromatography separating capacity, and is capable of separating mixtures which cannot be separated on an ordinary preparative liquid chromatography. Meanwhile the mobile phase used by the high performance liquid chromatograph is only 0.1-0.2 that of the ordinary preparative liquid chromatography. The high performance liquid chromatograph has a simple structure, and is easy to operate. The mass transfer velocity is improved, the analysis time is shortened, and the efficiency of an analytical column is increased.
Description
Technical field
The utility model relates to analytical instrument manufacturing technology field, is specially a kind of high performance liquid chromatograph.
Background technology
Existing high performance liquid chromatograph mainly consists of reservoir, mixer, high-pressure pump, injector, chromatographic column, detecting device and registering instrument.Mobile phase in reservoir is squeezed into system through mixer by high-pressure pump, sample solution enters system stream through injector, by mobile phase, be written in chromatographic column, because each component in sample solution has difference in translational speed, be separated into single component and in post, flow out successively, during by detecting device, sample concentration is converted into electric signal and is sent to registering instrument, data print with collection of illustrative plates form, and mobile phase is discharged by the output port of detecting device.
At present, preparative high-performance liquid chromatographic has become the main separation means of pharmaceutical industry.But still have the chromatographic behavior of a lot of compounds very similar, as steric isomer, diastereo-isomerism.The very challenging property of separated these compounds.Often can only reach part separation to these compounds.Use longer chromatographic column can obtain better degree of separation, but can be subject to the restriction that these chromatographic columns produce higher back-pressure.In addition, the organic solvent consumption of common preparation liquid phase is very large, to environment.
Utility model content
The utility model object is to provide a kind of high performance liquid chromatograph, to solve the problem proposing in above-mentioned background technology.
The technical matters that the utility model solves realizes by the following technical solutions:
A kind of high performance liquid chromatograph, comprise the reservoir, mixer, high-pressure pump, injector, chromatographic column, detecting device and the registering instrument that are linked in sequence, the feed tube of described reservoir is provided with solvent filter, between injector and chromatographic column, be provided with thermostat, the output port of detecting device is connected with circulating line, and the other end of circulating line is connected on the flow channel switching valve between mixer and high-pressure pump.
Further, described thermostat consists of the copper cooling circuit of hollow and its bottom aluminium matter pallet, and the entrance of injector is arranged on 1/4 place of cooling circuit.
The beneficial effects of the utility model are: the utlity model has superpower chromatogram separating capacity, can be separated in the potpourri that cannot separate on common preparative liquid chromatography, mobile phase used is 0.1～0.2 of common liquid chromatography simultaneously, and simple in structure, easy to operate; Improve mass transfer velocity simultaneously, shorten analysis time, and increase the efficiency of analytical column.
Accompanying drawing explanation
Fig. 1 is structural representation of the present utility model;
Fig. 2 is the structural representation of the utility model thermostat.
Embodiment
In order to make of the present utility modelly to realize technological means, creation characteristic, reach object and effect is easy to understand, below in conjunction with concrete diagram, further set forth the utility model.
As shown in Figure 1 and Figure 2, a kind of high performance liquid chromatograph, comprise the reservoir 1, mixer 2, high-pressure pump 3, injector 4, chromatographic column 5, detecting device 6 and the registering instrument 7 that are linked in sequence, the feed tube of described reservoir 1 is provided with solvent filter 8, between injector 4 and chromatographic column 5, be provided with thermostat 9, the output port of detecting device 6 is connected with circulating line 10, and the other end of circulating line 10 is connected on the flow channel switching valve 11 between mixer 2 and high-pressure pump 3.Described thermostat 9 consists of the copper cooling circuit 12 of hollow and its bottom aluminium matter pallet 13, and the entrance of injector 4 is arranged on 1/4 place of cooling circuit.The utlity model has superpower chromatogram separating capacity, can be separated in the potpourri that cannot separate on common preparative liquid chromatography, mobile phase used is 0.1～0.2 of common liquid chromatography simultaneously, and simple in structure, easy to operate; Improve mass transfer velocity simultaneously, shorten analysis time, and increase the efficiency of analytical column.
More than show and described ultimate principle of the present utility model and principal character and advantage of the present utility model.The technician of the industry should understand; the utility model is not restricted to the described embodiments; that in above-described embodiment and instructions, describes just illustrates principle of the present utility model; do not departing under the prerequisite of the utility model spirit and scope; the utility model also has various changes and modifications, and these changes and improvements all fall within the scope of claimed the utility model.Claimed scope of the present utility model is defined by appending claims and equivalent thereof.
Claims (2)
1. a high performance liquid chromatograph, comprise the reservoir, mixer, high-pressure pump, injector, chromatographic column, detecting device and the registering instrument that are linked in sequence, it is characterized in that: the feed tube of described reservoir is provided with solvent filter, between injector and chromatographic column, be provided with thermostat, the output port of detecting device is connected with circulating line, and the other end of circulating line is connected on the flow channel switching valve between mixer and high-pressure pump.
2. a kind of high performance liquid chromatograph according to claim 1, is characterized in that: described thermostat consists of the copper cooling circuit of hollow and its bottom aluminium matter pallet, and the entrance of injector is arranged on 1/4 place of cooling circuit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320588853.2U CN203490202U (en) | 2013-09-23 | 2013-09-23 | High performance liquid chromatograph |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201320588853.2U CN203490202U (en) | 2013-09-23 | 2013-09-23 | High performance liquid chromatograph |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN203490202U true CN203490202U (en) | 2014-03-19 |
Family
ID=50261024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201320588853.2U Expired - Fee Related CN203490202U (en) | 2013-09-23 | 2013-09-23 | High performance liquid chromatograph |
Country Status (1)
| Country | Link |
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| CN (1) | CN203490202U (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019006710A1 (en) * | 2017-07-05 | 2019-01-10 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid phase analysis device, and analysis method for liquid phase analysis device |
| CN110709695A (en) * | 2017-07-04 | 2020-01-17 | 株式会社岛津制作所 | Liquid feeding device and liquid chromatograph |
| CN114002047A (en) * | 2021-11-02 | 2022-02-01 | 湖北中烟工业有限责任公司 | Tobacco product aerosol condensation, trapping and extraction device and trapping and extraction method |
-
2013
- 2013-09-23 CN CN201320588853.2U patent/CN203490202U/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110709695A (en) * | 2017-07-04 | 2020-01-17 | 株式会社岛津制作所 | Liquid feeding device and liquid chromatograph |
| WO2019006710A1 (en) * | 2017-07-05 | 2019-01-10 | 深圳迈瑞生物医疗电子股份有限公司 | Liquid phase analysis device, and analysis method for liquid phase analysis device |
| US11204338B2 (en) | 2017-07-05 | 2021-12-21 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Liquid phase analysis device and analysis method for liquid phase analysis device |
| CN114002047A (en) * | 2021-11-02 | 2022-02-01 | 湖北中烟工业有限责任公司 | Tobacco product aerosol condensation, trapping and extraction device and trapping and extraction method |
| CN114002047B (en) * | 2021-11-02 | 2024-04-12 | 湖北中烟工业有限责任公司 | Tobacco product aerosol condensation trapping extraction device and trapping extraction method |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20140319 Termination date: 20140923 |
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| EXPY | Termination of patent right or utility model |